1YY8

crystal structure of the fab fragment from the monoclonal antibody cetuximab/erbitux/imc-c225

• Total interactions analyzed: 6
• Total true interactions: 2
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 191
  • Norm. En. per Res.: -2.9091
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-41.4393	-40.4701	-463.058	-544.9674	195	11	12	18871	3	22	23
C-D	-45.0416	-56.017	-454.57	-555.6286	191	15	12	18708	3	20	24

Interface residues

• A-B: ALA100A, ALA107B, ALA130A, ALA131B, ALA142B, ALA143B, ALA174B, ALA213A, ALA96B, ALA98B, ARG142A, ARG211A, ARG38B, ARG45A, ARG97B, ASN137A, ASN138A, ASN158A, ASN210A, ASN32A, ASN41A, ASN60B, ASN91A, ASP103B, ASP122A, ASP150B, ASP167A, ASP170A, ASP1A, ASP58B, ASP85A, CYS134A, CYS146B, CYS88A, CYS95B, GLN111B, GLN124A, GLN160A, GLN166A, GLN177B, GLN37A, GLN38A, GLN39B, GLN6A, GLN6B, GLN89A, GLN90A, GLU105B, GLU123A, GLU161A, GLU165A, GLU46B, GLU53A, GLY101A, GLY110B, GLY112B, GLY139B, GLY140B, GLY145B, GLY157A, GLY168B, GLY212A, GLY42A, GLY42B, GLY44B, GLY49B, GLY99A, HIS170B, HIS34A, HIS35B, ILE117A, ILE33A, ILE48A, ILE55A, ILE92B, LEU125A, LEU130B, LEU135A, LEU136A, LEU144B, LEU147B, LEU175A, LEU176B, LEU179A, LEU181A, LEU181B, LEU184B, LEU45B, LEU46A, LEU47A, LEU48B, LEU99B, LYS126A, LYS135B, LYS149B, LYS169A, LYS207A, LYS215B, LYS220B, LYS43B, LYS49A, PHE106B, PHE116A, PHE118A, PHE128B, PHE139A, PHE172B, PHE209A, PHE63B, PHE98A, PRO113A, PRO119A, PRO120A, PRO129B, PRO132B, PRO155B, PRO173B, PRO219B, PRO44A, PRO62B, PRO95A, SER114A, SER121A, SER126B, SER127A, SER131A, SER133B, SER136B, SER138B, SER159A, SER162A, SER168A, SER174A, SER176A, SER177A, SER178B, SER179B, SER183B, SER185B, SER186B, SER192B, SER208A, SER221B, SER40B, SER43A, SER54A, SER56A, THR100B, THR129A, THR137B, THR141B, THR164A, THR171B, THR172A, THR178A, THR180A, THR189B, THR40A, THR61B, THR64B, THR96A, THR97A, TRP109B, TRP35A, TRP36B, TRP47B, TRP52B, TRP94A, TYR102B, TYR104B, TYR108B, TYR173A, TYR182B, TYR186A, TYR36A, TYR50A, TYR59B, TYR86A, TYR87A, TYR94B, VAL115A, VAL127B, VAL132A, VAL133A, VAL163A, VAL169B, VAL175B, VAL187B, VAL188B, VAL190B, VAL205A, VAL213B, VAL217B, VAL37B, VAL50B
• C-D: ALA100C, ALA107D, ALA130C, ALA131D, ALA142D, ALA143D, ALA174D, ALA213C, ALA96D, ALA98D, ARG142C, ARG211C, ARG38D, ARG45C, ARG97D, ASN137C, ASN138C, ASN210C, ASN32C, ASN41C, ASN60D, ASN91C, ASP103D, ASP122C, ASP150D, ASP167C, ASP170C, ASP1C, ASP58D, ASP85C, CYS134C, CYS146D, CYS88C, CYS95D, GLN111D, GLN124C, GLN160C, GLN166C, GLN177D, GLN37C, GLN38C, GLN39D, GLN6C, GLN6D, GLN89C, GLN90C, GLU105D, GLU123C, GLU161C, GLU165C, GLU46D, GLU53C, GLY101C, GLY110D, GLY112D, GLY139D, GLY145D, GLY168D, GLY180D, GLY212C, GLY42C, GLY42D, GLY44D, GLY49D, GLY99C, HIS170D, HIS34C, HIS35D, ILE117C, ILE33C, ILE48C, ILE55C, ILE58C, ILE92D, LEU125C, LEU130D, LEU135C, LEU136C, LEU144D, LEU147D, LEU175C, LEU176D, LEU179C, LEU181C, LEU181D, LEU184D, LEU45D, LEU46C, LEU47C, LEU48D, LEU99D, LYS126C, LYS135D, LYS149D, LYS169C, LYS207C, LYS215D, LYS220D, LYS43D, LYS49C, PHE106D, PHE116C, PHE118C, PHE128D, PHE139C, PHE172D, PHE209C, PHE63D, PHE98C, PRO113C, PRO119C, PRO120C, PRO129D, PRO132D, PRO173D, PRO219D, PRO44C, PRO62D, PRO95C, SER114C, SER121C, SER126D, SER127C, SER131C, SER133D, SER136D, SER138D, SER159C, SER162C, SER168C, SER174C, SER176C, SER177C, SER178D, SER179D, SER183D, SER185D, SER186D, SER208C, SER221D, SER40D, SER43C, SER54C, SER56C, THR100D, THR129C, THR137D, THR141D, THR164C, THR171D, THR172C, THR178C, THR180C, THR189D, THR40C, THR61D, THR64D, THR96C, THR97C, TRP109D, TRP35C, TRP36D, TRP47D, TRP52D, TRP94C, TYR102D, TYR104D, TYR108D, TYR173C, TYR182D, TYR186C, TYR36C, TYR50C, TYR59D, TYR86C, TYR87C, TYR94D, VAL115C, VAL127D, VAL132C, VAL133C, VAL163C, VAL169D, VAL175D, VAL187D, VAL188D, VAL190D, VAL213D, VAL217D, VAL37D, VAL50D