1YKP

protocatechuate 3,4-dioxygenase y408h mutant bound to dhb

• Total interactions analyzed: 66
• Total true interactions: 35
• Strongest Interaction:
  • Chains: K-L
  • Int. Res.: 270
  • Norm. En. per Res.: -5.1022
• Hub Node: B(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-208.8034	-70.6639	-1042.11	-1321.5774	273	47	24	41429	14	63	60
A-C	-4.5372	1.8473	-27.5229	-30.2127	19	1	0	903	3	7	7
A-D	-12.1578	0.0	-5.7863	-17.9441	7	0	0	139	0	2	1
A-E	-5.0241	1.3864	-23.0794	-26.717	16	0	0	825	2	7	6
A-F	0.0	-4.8721	-19.8061	-24.6782	28	0	0	884	0	7	4
B-C	0.0	-4.7906	-18.1512	-22.9418	27	0	0	870	0	7	4
B-D	-17.6202	0.0	-52.7802	-70.4004	44	3	1	2750	1	8	10
B-E	-4.7636	0.0	-4.7585	-9.5222	7	0	0	125	0	2	1
B-F	-11.5983	0.0	-63.6013	-75.1996	44	3	1	2806	1	8	10
B-H	-29.9633	0.5457	-383.61	-413.0275	138	9	4	15871	0	27	25
B-I	-14.2331	0.0	-57.7422	-71.9753	22	2	1	2047	0	2	3
B-J	-13.5726	7.5042	-104.554	-110.6225	50	1	1	3823	0	17	14
C-D	-235.4188	-75.2185	-1035.62	-1346.2573	273	52	23	41124	13	60	60
C-E	-5.1264	2.0358	-23.7768	-26.8675	18	1	0	868	3	7	6
C-F	-10.6778	0.0	-6.0147	-16.6924	7	0	0	145	0	2	1
C-H	-13.1512	0.0	-53.9029	-67.0541	22	1	1	2043	0	2	3
D-E	0.0	-5.0533	-21.7491	-26.8024	29	1	0	923	0	7	4
D-F	-22.8718	0.0	-62.4466	-85.3184	45	4	1	2899	1	8	9
D-H	-17.6362	6.8484	-96.2945	-107.0823	50	2	1	3665	0	18	13
E-F	-244.9486	-70.1338	-997.777	-1312.8594	273	51	23	40834	12	62	60
G-H	-245.8548	-72.7367	-1025.7	-1344.2916	273	45	23	41161	13	64	60
G-I	0.0	2.0397	-24.9276	-22.8879	17	0	0	853	3	7	6
G-J	-2.822	0.0	-5.1723	-7.9943	7	0	0	134	0	2	1
G-K	-4.1471	1.0529	-24.7479	-27.8422	19	1	0	912	3	7	7
G-L	0.0	-4.8248	-22.2083	-27.0331	29	0	0	897	0	8	4
H-I	0.0	-6.0361	-18.7948	-24.8309	25	0	0	858	0	7	4
H-J	-22.3421	-12.5733	-57.0362	-91.9516	44	10	1	2900	1	8	10
H-K	-5.2965	0.0	-5.2364	-10.5329	8	0	0	134	0	2	1
H-L	-23.8855	-12.3216	-61.2195	-97.4266	44	6	1	2846	1	8	10
I-J	-229.5093	-82.9244	-1037.96	-1350.3937	274	54	23	41117	12	63	59
I-K	-4.339	0.9165	-23.8773	-27.2998	17	2	0	834	2	7	6
I-L	-10.8557	0.0	-4.8989	-15.7546	7	0	0	126	0	2	1
J-K	0.0	-5.0489	-20.9089	-25.9578	29	0	0	889	0	7	4
J-L	-32.727	0.0	-62.6315	-95.3585	45	7	1	2819	1	8	9
K-L	-263.3997	-62.3657	-1051.82	-1377.5854	270	62	24	41617	12	63	60

Interface residues

• A-B: ALA117A, ALA118A, ALA132A, ALA13A, ALA22A, ALA25A, ALA26A, ALA302B, ALA319B, ALA329B, ALA335B, ALA358B, ALA402B, ALA471B, ALA496B, ALA500B, ALA73A, ALA82A, ARG133A, ARG142A, ARG166A, ARG167A, ARG188A, ARG307B, ARG311B, ARG313B, ARG31A, ARG330B, ARG333B, ARG407B, ARG409B, ARG414B, ARG428B, ARG450B, ARG457B, ARG528B, ARG531B, ARG64A, ARG94A, ASN115A, ASN116A, ASN127A, ASN136A, ASN159A, ASN28A, ASN350B, ASN366B, ASN369B, ASN403B, ASN412B, ASN497B, ASN537B, ASN59A, ASN76A, ASN84A, ASN87A, ASN90A, ASP100A, ASP199A, ASP304B, ASP312B, ASP32A, ASP360B, ASP386B, ASP413B, ASP524B, ASP57A, ASP65A, ASP74A, ASP81A, CYS489B, GLN11A, GLN163A, GLN190A, GLN303B, GLN334B, GLN33A, GLN341B, GLN387B, GLN401B, GLN477B, GLN502B, GLN503B, GLN530B, GLN72A, GLN80A, GLU162A, GLU192A, GLU194A, GLU24A, GLU345B, GLU34A, GLU398B, GLU3A, GLU499B, GLU536B, GLU69A, GLU78A, GLU7A, GLU86A, GLY119A, GLY134A, GLY14A, GLY191A, GLY193A, GLY20A, GLY27A, GLY348B, GLY355B, GLY357B, GLY389B, GLY406B, GLY424B, GLY425B, GLY427B, GLY464B, GLY529B, GLY58A, GLY60A, GLY77A, GLY93A, HIS125A, HIS138A, HIS140A, HIS18A, HIS316B, HIS353B, HIS359B, HIS408B, HIS410B, HIS460B, HIS462B, HIS61A, ILE126A, ILE128A, ILE135A, ILE137A, ILE161A, ILE189A, ILE19A, ILE2A, ILE310B, ILE328B, ILE339B, ILE343B, ILE35A, ILE461B, ILE465B, ILE470B, ILE475B, ILE491B, ILE495B, ILE505B, ILE525B, LEU130A, LEU139A, LEU158A, LEU160A, LEU170A, LEU21A, LEU23A, LEU320B, LEU336B, LEU354B, LEU363B, LEU396B, LEU419B, LEU474B, LEU478B, LEU4A, LEU504B, LEU527B, LEU5A, LEU62A, LEU85A, LYS318B, LYS325B, LYS390B, LYS411B, LYS473B, LYS493B, MET122A, MET399B, PHE131A, PHE197A, PHE198A, PHE200A, PHE308B, PHE351B, PHE356B, PHE367B, PHE423B, PHE439B, PHE463B, PHE523B, PHE67A, PHE92A, PHE99A, PRO156A, PRO15A, PRO29A, PRO301B, PRO317B, PRO322B, PRO332B, PRO340B, PRO349B, PRO448B, PRO468B, PRO490B, PRO6A, PRO9A, SER10A, SER129A, SER327B, SER331B, SER338B, SER342B, SER344B, SER352B, SER466B, SER469B, SER494B, SER66A, SER91A, THR12A, THR141A, THR169A, THR195A, THR30A, THR321B, THR326B, THR346B, THR347B, THR472B, THR476B, THR533B, THR8A, THR97A, THR98A, TRP315B, TRP36A, TRP400B, TRP449B, TRP71A, TYR144A, TYR16A, TYR324B, TYR388B, TYR415B, TYR447B, TYR479B, TYR56A, TYR79A, TYR83A, VAL113A, VAL114A, VAL120A, VAL157A, VAL17A, VAL196A, VAL309B, VAL337B, VAL384B, VAL385B, VAL397B, VAL426B, VAL492B, VAL501B, VAL526B, VAL55A, VAL63A, VAL70A
• A-C: ARG133A, ARG166C, ARG64A, ASN59A, ASP57A, ASP65A, GLN163C, GLN165C, GLU162C, GLU192C, GLU194C, GLY191C, GLY193C, GLY60A, HIS61A, LEU62A, PHE99A, PRO164C, VAL63A
• A-D: ALA335D, ARG333D, ASN59A, GLN190A, GLN334D, GLY58A, HIS61A
• A-E: ARG133E, ARG166A, ARG64E, ASN59E, ASP57E, ASP65E, GLN163A, GLN165A, GLU162A, GLU194A, GLY60E, HIS61E, LEU62E, PHE99E, PRO164A, VAL63E
• A-F: ALA329F, ARG330F, ARG450F, ASN116A, ASN159A, ASN451F, ASN454F, ASP199A, GLN163A, GLU162A, GLU3A, GLY452F, ILE161A, ILE2A, LEU160A, LEU485F, LYS325F, MET488F, PHE197A, PHE198A, PHE200A, PRO156A, PRO1A, PRO453F, PRO484F, PRO487F, THR326F, VAL157A
• B-C: ALA329B, ARG166C, ARG330B, ARG450B, ASN451B, ASN454B, ASP199C, ASP483B, GLN163C, GLU162C, GLU3C, GLY452B, ILE2C, LEU160C, LEU485B, LYS325B, MET488B, PHE197C, PHE198C, PHE200C, PRO156C, PRO1C, PRO453B, PRO484B, PRO487B, THR326B, VAL157C
• B-D: ALA329B, ALA335D, ARG311D, ARG313D, ARG333B, ARG333D, ARG450B, ARG528D, ARG531D, ASN314D, ASN451B, ASN454B, ASN537D, ASP312D, ASP323B, ASP455B, CYS538D, GLN334D, GLN341D, GLY452B, ILE310D, ILE328B, ILE339D, LEU320B, LEU320D, LEU336D, LEU416B, LYS318D, LYS325B, LYS493B, MET488B, PHE535D, PRO322B, PRO332D, PRO340D, PRO453B, PRO490B, SER327B, SER338D, THR326B, TRP449B, TYR324B, VAL309D, VAL337D
• B-E: ALA335B, ARG333B, ASN59E, GLN190E, GLN334B, GLY58E, HIS61E
• B-F: ALA329F, ALA335B, ARG311B, ARG313B, ARG333B, ARG333F, ARG450F, ARG528B, ARG531B, ASN314B, ASN451F, ASN454F, ASN537B, ASP312B, ASP323F, ASP455F, CYS538B, GLN334B, GLN341B, GLY452F, ILE310B, ILE328F, ILE339B, LEU320B, LEU320F, LEU336B, LEU416F, LYS318B, LYS325F, LYS493F, MET488F, PHE308B, PRO322F, PRO332B, PRO340B, PRO453F, PRO490F, SER327F, SER338B, THR326F, TRP449F, TYR324F, VAL309B, VAL337B
• B-H: ALA404B, ALA404H, ALA417B, ALA417H, ALA459B, ALA459H, ALA506B, ALA506H, ALA513B, ALA513H, ALA520B, ALA520H, ARG377B, ARG377H, ARG407B, ARG407H, ARG414B, ARG414H, ARG440B, ARG440H, ARG450B, ARG450H, ARG457B, ARG457H, ASN403B, ASN403H, ASN422B, ASN422H, ASN451B, ASN451H, ASN454B, ASN454H, ASN511B, ASN511H, ASN512B, ASN512H, ASN514B, ASN514H, ASP420B, ASP420H, ASP455B, ASP455H, ASP483B, ASP483H, ASP509B, ASP509H, ASP517B, ASP517H, CYS489B, CYS518B, CYS518H, GLU376B, GLU376H, GLU481B, GLU481H, GLY371B, GLY371H, GLY375B, GLY375H, GLY405B, GLY405H, GLY406B, GLY406H, GLY445B, GLY445H, GLY452B, GLY452H, GLY482B, GLY482H, ILE374B, ILE374H, ILE378B, ILE378H, ILE442B, ILE442H, ILE486B, ILE486H, LEU364B, LEU364H, LEU372B, LEU372H, LEU416B, LEU416H, LEU419B, LEU419H, LEU485B, LEU485H, LEU508B, LEU508H, LEU519B, LEU519H, LYS443B, LYS443H, LYS507B, LYS507H, MET488B, MET488H, MET510B, MET510H, MET516B, MET516H, PHE423B, PHE423H, PHE480B, PHE480H, PRO373B, PRO373H, PRO418B, PRO418H, PRO421B, PRO421H, PRO444B, PRO444H, PRO446B, PRO446H, PRO448B, PRO448H, PRO453B, PRO453H, PRO458B, PRO458H, PRO484B, PRO484H, PRO487B, PRO487H, PRO490B, PRO515B, PRO515H, TRP449B, TRP449H, TRP456B, TRP456H, TYR415B, TYR415H, TYR447B, TYR447H, TYR521B, TYR521H
• B-I: ALA506B, ALA520B, ARG522B, ASN511B, ASN512B, ASP509B, ASP524B, GLU3I, GLU481B, ILE2I, ILE505B, LEU160I, LEU4I, LEU508B, LYS507B, MET510B, MET516B, PHE200I, PHE523B, PRO1I, PRO515B, TYR521B
• B-J: ALA358B, ALA381B, ALA513B, ALA520B, ARG307J, ARG377B, ARG440B, ARG522B, ARG531J, ASN511B, ASN512B, ASN514B, ASN537J, ASP362B, ASP509B, ASP517B, CYS518B, CYS538J, GLN341J, GLN387J, GLU536J, GLY529J, HIS359B, HIS361B, HIS534J, ILE310J, ILE339J, ILE378B, ILE379B, LEU363B, LEU364B, LEU365B, LEU372B, LEU519B, LYS532J, MET510B, MET516B, PHE308J, PHE439B, PHE535J, PRO340J, PRO515B, SER338J, SER438B, THR441B, THR533J, TYR388J, TYR437B, VAL309J, VAL380B
• C-D: ALA117C, ALA118C, ALA123C, ALA132C, ALA13C, ALA22C, ALA25C, ALA26C, ALA302D, ALA319D, ALA329D, ALA335D, ALA358D, ALA402D, ALA471D, ALA496D, ALA500D, ALA73C, ALA82C, ARG133C, ARG142C, ARG166C, ARG167C, ARG188C, ARG307D, ARG311D, ARG313D, ARG31C, ARG330D, ARG333D, ARG383D, ARG407D, ARG409D, ARG414D, ARG428D, ARG450D, ARG457D, ARG528D, ARG531D, ARG64C, ARG94C, ASN115C, ASN116C, ASN127C, ASN136C, ASN159C, ASN28C, ASN350D, ASN366D, ASN369D, ASN403D, ASN412D, ASN497D, ASN537D, ASN59C, ASN84C, ASN87C, ASN90C, ASP100C, ASP199C, ASP304D, ASP312D, ASP32C, ASP360D, ASP386D, ASP413D, ASP524D, ASP57C, ASP65C, ASP74C, ASP81C, CYS489D, GLN11C, GLN163C, GLN190C, GLN303D, GLN334D, GLN33C, GLN341D, GLN387D, GLN401D, GLN477D, GLN502D, GLN503D, GLN530D, GLN72C, GLN80C, GLU162C, GLU192C, GLU194C, GLU24C, GLU345D, GLU34C, GLU398D, GLU3C, GLU499D, GLU536D, GLU69C, GLU78C, GLU7C, GLU86C, GLY119C, GLY134C, GLY14C, GLY191C, GLY193C, GLY20C, GLY27C, GLY348D, GLY355D, GLY357D, GLY389D, GLY406D, GLY424D, GLY425D, GLY427D, GLY464D, GLY529D, GLY58C, GLY60C, GLY77C, GLY93C, HIS125C, HIS138C, HIS140C, HIS18C, HIS316D, HIS353D, HIS359D, HIS408D, HIS410D, HIS460D, HIS462D, HIS61C, ILE126C, ILE128C, ILE135C, ILE137C, ILE161C, ILE189C, ILE19C, ILE2C, ILE310D, ILE328D, ILE339D, ILE343D, ILE35C, ILE461D, ILE465D, ILE470D, ILE475D, ILE491D, ILE495D, ILE505D, ILE525D, LEU130C, LEU139C, LEU158C, LEU160C, LEU170C, LEU21C, LEU23C, LEU320D, LEU336D, LEU354D, LEU363D, LEU396D, LEU419D, LEU474D, LEU478D, LEU4C, LEU504D, LEU527D, LEU5C, LEU62C, LEU85C, LYS318D, LYS325D, LYS390D, LYS411D, LYS473D, LYS493D, MET122C, MET399D, PHE131C, PHE197C, PHE198C, PHE200C, PHE308D, PHE351D, PHE356D, PHE367D, PHE423D, PHE439D, PHE463D, PHE523D, PHE67C, PHE92C, PHE99C, PRO156C, PRO15C, PRO29C, PRO301D, PRO317D, PRO322D, PRO332D, PRO340D, PRO349D, PRO448D, PRO468D, PRO490D, PRO6C, PRO9C, SER10C, SER129C, SER327D, SER331D, SER338D, SER342D, SER344D, SER352D, SER466D, SER469D, SER494D, SER66C, SER91C, THR12C, THR141C, THR169C, THR195C, THR30C, THR321D, THR326D, THR346D, THR347D, THR472D, THR476D, THR533D, THR8C, THR98C, TRP315D, TRP36C, TRP400D, TRP449D, TRP71C, TYR144C, TYR16C, TYR324D, TYR388D, TYR415D, TYR447D, TYR479D, TYR56C, TYR79C, TYR83C, VAL113C, VAL114C, VAL120C, VAL157C, VAL17C, VAL196C, VAL309D, VAL337D, VAL384D, VAL385D, VAL397D, VAL426D, VAL492D, VAL501D, VAL526D, VAL55C, VAL63C, VAL70C
• C-E: ARG133C, ARG166E, ARG64C, ASN59C, ASP57C, ASP65C, GLN163E, GLN165E, GLU162E, GLU194E, GLY191E, GLY193E, GLY60C, HIS61C, LEU62C, PHE99C, PRO164E, VAL63C
• C-F: ALA335F, ARG333F, ASN59C, GLN190C, GLN334F, GLY58C, HIS61C
• C-H: ALA506H, ALA520H, ARG522H, ASN511H, ASN512H, ASP509H, ASP524H, GLU3C, GLU481H, ILE2C, ILE505H, LEU160C, LEU4C, LEU508H, LYS507H, MET510H, MET516H, PHE200C, PHE523H, PRO1C, PRO515H, TYR521H
• D-E: ALA329D, ARG166E, ARG330D, ARG450D, ASN116E, ASN451D, ASN454D, ASP199E, ASP483D, GLN163E, GLU162E, GLU3E, GLY452D, ILE161E, ILE2E, LEU160E, LEU485D, LYS325D, MET488D, PHE197E, PHE198E, PHE200E, PRO156E, PRO1E, PRO453D, PRO484D, PRO487D, THR326D, VAL157E
• D-F: ALA329D, ALA335F, ARG311F, ARG313F, ARG333D, ARG333F, ARG450D, ARG528F, ARG531F, ASN314F, ASN451D, ASN454D, ASN537F, ASP312F, ASP323D, ASP455D, CYS538F, GLN334F, GLN341F, GLU536F, GLY452D, ILE310F, ILE328D, ILE339F, LEU320D, LEU320F, LEU336F, LEU416D, LYS318F, LYS325D, LYS493D, MET488D, PHE535F, PRO322D, PRO332F, PRO340F, PRO453D, PRO490D, SER327D, SER338F, THR326D, TRP449D, TYR324D, VAL309F, VAL337F
• D-H: ALA358H, ALA381H, ALA513H, ALA520H, ARG307D, ARG377H, ARG440H, ARG522H, ARG531D, ASN511H, ASN512H, ASN514H, ASN537D, ASP362H, ASP509H, ASP517H, CYS518H, CYS538D, GLN341D, GLN387D, GLU536D, GLY529D, HIS359H, HIS361H, HIS534D, ILE310D, ILE339D, ILE379H, LEU363H, LEU364H, LEU365H, LEU372H, LEU519H, LYS532D, MET510H, MET516H, PHE308D, PHE439H, PHE535D, PRO340D, PRO515H, SER338D, SER438H, THR441H, THR533D, TYR388D, TYR436H, TYR437H, VAL309D, VAL380H
• E-F: ALA117E, ALA118E, ALA132E, ALA13E, ALA22E, ALA25E, ALA26E, ALA302F, ALA319F, ALA329F, ALA335F, ALA358F, ALA402F, ALA471F, ALA496F, ALA500F, ALA73E, ALA82E, ARG133E, ARG142E, ARG166E, ARG188E, ARG307F, ARG311F, ARG313F, ARG31E, ARG330F, ARG333F, ARG383F, ARG407F, ARG409F, ARG414F, ARG428F, ARG450F, ARG457F, ARG528F, ARG531F, ARG64E, ARG94E, ASN115E, ASN116E, ASN127E, ASN136E, ASN159E, ASN28E, ASN350F, ASN366F, ASN369F, ASN403F, ASN412F, ASN497F, ASN537F, ASN59E, ASN76E, ASN84E, ASN87E, ASN90E, ASP100E, ASP199E, ASP304F, ASP312F, ASP32E, ASP360F, ASP386F, ASP413F, ASP524F, ASP57E, ASP65E, ASP74E, ASP81E, CYS489F, GLN11E, GLN163E, GLN190E, GLN303F, GLN334F, GLN33E, GLN341F, GLN387F, GLN401F, GLN477F, GLN502F, GLN503F, GLN530F, GLN72E, GLN80E, GLU162E, GLU192E, GLU194E, GLU24E, GLU345F, GLU34E, GLU398F, GLU3E, GLU499F, GLU536F, GLU69E, GLU78E, GLU7E, GLU86E, GLY119E, GLY134E, GLY14E, GLY191E, GLY193E, GLY20E, GLY27E, GLY348F, GLY355F, GLY357F, GLY389F, GLY406F, GLY424F, GLY425F, GLY427F, GLY464F, GLY529F, GLY58E, GLY60E, GLY77E, GLY93E, HIS125E, HIS138E, HIS140E, HIS18E, HIS316F, HIS353F, HIS359F, HIS361F, HIS408F, HIS410F, HIS460F, HIS462F, HIS61E, ILE126E, ILE128E, ILE135E, ILE137E, ILE161E, ILE189E, ILE19E, ILE2E, ILE310F, ILE328F, ILE339F, ILE343F, ILE35E, ILE465F, ILE470F, ILE475F, ILE491F, ILE495F, ILE505F, ILE525F, LEU130E, LEU139E, LEU158E, LEU160E, LEU170E, LEU21E, LEU23E, LEU320F, LEU336F, LEU354F, LEU363F, LEU396F, LEU419F, LEU474F, LEU478F, LEU4E, LEU504F, LEU527F, LEU5E, LEU62E, LEU85E, LYS318F, LYS325F, LYS390F, LYS411F, LYS473F, LYS493F, MET122E, MET399F, PHE131E, PHE197E, PHE198E, PHE200E, PHE308F, PHE351F, PHE356F, PHE367F, PHE423F, PHE439F, PHE463F, PHE523F, PHE67E, PHE92E, PHE99E, PRO111E, PRO156E, PRO15E, PRO29E, PRO301F, PRO317F, PRO322F, PRO332F, PRO340F, PRO349F, PRO448F, PRO468F, PRO490F, PRO6E, PRO9E, SER10E, SER129E, SER327F, SER331F, SER338F, SER342F, SER344F, SER352F, SER466F, SER469F, SER494F, SER66E, SER91E, THR12E, THR141E, THR169E, THR195E, THR30E, THR321F, THR326F, THR346F, THR347F, THR472F, THR476F, THR533F, THR8E, THR97E, THR98E, TRP315F, TRP36E, TRP400F, TRP449F, TRP71E, TYR144E, TYR16E, TYR324F, TYR388F, TYR415F, TYR447F, TYR479F, TYR56E, TYR79E, TYR83E, VAL114E, VAL120E, VAL157E, VAL17E, VAL196E, VAL309F, VAL337F, VAL384F, VAL385F, VAL397F, VAL426F, VAL492F, VAL501F, VAL526F, VAL55E, VAL63E, VAL70E
• G-H: ALA117G, ALA118G, ALA132G, ALA13G, ALA22G, ALA25G, ALA26G, ALA302H, ALA319H, ALA329H, ALA335H, ALA358H, ALA402H, ALA471H, ALA496H, ALA500H, ALA73G, ALA82G, ARG133G, ARG142G, ARG166G, ARG188G, ARG307H, ARG311H, ARG313H, ARG31G, ARG330H, ARG333H, ARG407H, ARG409H, ARG414H, ARG428H, ARG450H, ARG457H, ARG528H, ARG531H, ARG64G, ARG94G, ASN115G, ASN116G, ASN127G, ASN136G, ASN159G, ASN28G, ASN350H, ASN366H, ASN369H, ASN403H, ASN412H, ASN497H, ASN537H, ASN59G, ASN76G, ASN84G, ASN87G, ASN90G, ASP100G, ASP199G, ASP304H, ASP312H, ASP32G, ASP360H, ASP386H, ASP413H, ASP524H, ASP57G, ASP65G, ASP74G, ASP81G, CYS489H, GLN11G, GLN163G, GLN190G, GLN303H, GLN334H, GLN33G, GLN341H, GLN387H, GLN401H, GLN477H, GLN502H, GLN503H, GLN530H, GLN72G, GLN80G, GLU162G, GLU192G, GLU194G, GLU24G, GLU345H, GLU34G, GLU398H, GLU3G, GLU499H, GLU536H, GLU69G, GLU78G, GLU7G, GLU86G, GLY119G, GLY134G, GLY14G, GLY191G, GLY193G, GLY20G, GLY27G, GLY348H, GLY355H, GLY357H, GLY389H, GLY406H, GLY424H, GLY425H, GLY427H, GLY464H, GLY529H, GLY58G, GLY60G, GLY77G, GLY93G, HIS125G, HIS138G, HIS140G, HIS18G, HIS316H, HIS353H, HIS359H, HIS361H, HIS408H, HIS410H, HIS460H, HIS462H, HIS61G, ILE126G, ILE128G, ILE135G, ILE137G, ILE161G, ILE189G, ILE19G, ILE2G, ILE310H, ILE328H, ILE339H, ILE343H, ILE35G, ILE461H, ILE465H, ILE470H, ILE475H, ILE491H, ILE495H, ILE505H, ILE525H, LEU130G, LEU139G, LEU158G, LEU160G, LEU170G, LEU21G, LEU23G, LEU320H, LEU336H, LEU354H, LEU363H, LEU396H, LEU419H, LEU474H, LEU478H, LEU4G, LEU504H, LEU527H, LEU5G, LEU62G, LEU85G, LYS318H, LYS325H, LYS390H, LYS411H, LYS473H, LYS493H, MET122G, MET399H, PHE131G, PHE197G, PHE198G, PHE200G, PHE308H, PHE351H, PHE356H, PHE367H, PHE423H, PHE439H, PHE463H, PHE523H, PHE67G, PHE92G, PHE99G, PRO156G, PRO15G, PRO29G, PRO301H, PRO317H, PRO322H, PRO332H, PRO340H, PRO349H, PRO448H, PRO468H, PRO490H, PRO6G, PRO9G, SER10G, SER129G, SER327H, SER331H, SER338H, SER342H, SER344H, SER352H, SER466H, SER469H, SER494H, SER66G, SER91G, THR12G, THR141G, THR169G, THR195G, THR30G, THR321H, THR326H, THR346H, THR347H, THR472H, THR476H, THR533H, THR8G, THR97G, THR98G, TRP315H, TRP36G, TRP400H, TRP449H, TRP71G, TYR144G, TYR16G, TYR324H, TYR388H, TYR415H, TYR447H, TYR479H, TYR56G, TYR79G, TYR83G, VAL113G, VAL114G, VAL120G, VAL157G, VAL17G, VAL196G, VAL309H, VAL337H, VAL384H, VAL385H, VAL397H, VAL426H, VAL492H, VAL501H, VAL526H, VAL55G, VAL63G, VAL70G
• G-I: ARG133G, ARG166I, ARG64G, ASN59G, ASP57G, ASP65G, GLN163I, GLN165I, GLU162I, GLU194I, GLY191I, GLY60G, HIS61G, LEU62G, PHE99G, PRO164I, VAL63G
• G-J: ALA335J, ARG333J, ASN59G, GLN190G, GLN334J, GLY58G, HIS61G
• G-K: ARG133K, ARG166G, ARG167G, ARG64K, ASN59K, ASP57K, ASP65K, GLN163G, GLN165G, GLU162G, GLU194G, GLY191G, GLY193G, GLY60K, HIS61K, LEU62K, PHE99K, PRO164G, VAL63K
• G-L: ALA329L, ARG166G, ARG330L, ARG450L, ASN116G, ASN159G, ASN451L, ASN454L, ASP199G, GLN163G, GLU162G, GLU3G, GLY452L, ILE161G, ILE2G, LEU160G, LEU485L, LYS325L, MET488L, PHE197G, PHE198G, PHE200G, PRO156G, PRO1G, PRO453L, PRO484L, PRO487L, THR326L, VAL157G
• H-I: ARG330H, ARG450H, ASN116I, ASN451H, ASN454H, ASP199I, GLN163I, GLU162I, GLU3I, GLY452H, ILE2I, LEU160I, LEU485H, LYS325H, MET488H, PHE197I, PHE198I, PHE200I, PRO156I, PRO1I, PRO453H, PRO484H, PRO487H, THR326H, VAL157I
• H-J: ALA329H, ALA335J, ARG311J, ARG313J, ARG333H, ARG333J, ARG450H, ARG528J, ARG531J, ASN314J, ASN451H, ASN454H, ASN537J, ASP312J, ASP323H, ASP455H, CYS538J, GLN334J, GLN341J, GLY452H, ILE310J, ILE328H, ILE339J, LEU320H, LEU320J, LEU336J, LEU416H, LYS318J, LYS325H, LYS493H, PHE308J, PHE535J, PRO322H, PRO332J, PRO340J, PRO453H, PRO490H, SER327H, SER338J, THR326H, TRP449H, TYR324H, VAL309J, VAL337J
• H-K: ALA335H, ARG333H, ASN59K, ASP57K, GLN190K, GLN334H, GLY58K, HIS61K
• H-L: ALA329L, ALA335H, ARG311H, ARG313H, ARG333H, ARG333L, ARG450L, ARG528H, ARG531H, ASN314H, ASN451L, ASN454L, ASN537H, ASP312H, ASP323L, ASP455L, CYS538H, GLN334H, GLN341H, GLY452L, ILE310H, ILE328L, ILE339H, LEU320H, LEU320L, LEU336H, LEU416L, LYS318H, LYS325L, LYS493L, MET488L, PHE308H, PRO322L, PRO332H, PRO340H, PRO453L, PRO490L, SER327L, SER338H, THR326L, TRP449L, TYR324L, VAL309H, VAL337H
• I-J: ALA117I, ALA118I, ALA123I, ALA132I, ALA13I, ALA22I, ALA25I, ALA26I, ALA302J, ALA319J, ALA329J, ALA335J, ALA358J, ALA402J, ALA471J, ALA496J, ALA500J, ALA73I, ALA82I, ARG133I, ARG142I, ARG166I, ARG167I, ARG188I, ARG307J, ARG311J, ARG313J, ARG31I, ARG330J, ARG333J, ARG383J, ARG407J, ARG409J, ARG414J, ARG428J, ARG450J, ARG457J, ARG528J, ARG531J, ARG64I, ARG94I, ASN115I, ASN116I, ASN127I, ASN136I, ASN159I, ASN28I, ASN350J, ASN366J, ASN369J, ASN403J, ASN412J, ASN497J, ASN537J, ASN59I, ASN84I, ASN87I, ASN90I, ASP100I, ASP199I, ASP304J, ASP312J, ASP32I, ASP360J, ASP386J, ASP413J, ASP524J, ASP57I, ASP65I, ASP74I, ASP81I, CYS489J, GLN11I, GLN163I, GLN190I, GLN303J, GLN334J, GLN33I, GLN341J, GLN387J, GLN401J, GLN477J, GLN502J, GLN503J, GLN530J, GLN72I, GLN80I, GLU162I, GLU192I, GLU194I, GLU24I, GLU345J, GLU34I, GLU398J, GLU3I, GLU499J, GLU536J, GLU69I, GLU78I, GLU7I, GLU86I, GLY119I, GLY134I, GLY14I, GLY191I, GLY193I, GLY20I, GLY27I, GLY348J, GLY355J, GLY357J, GLY389J, GLY406J, GLY424J, GLY425J, GLY427J, GLY464J, GLY529J, GLY58I, GLY60I, GLY77I, GLY93I, HIS125I, HIS138I, HIS140I, HIS18I, HIS316J, HIS353J, HIS359J, HIS361J, HIS408J, HIS410J, HIS460J, HIS462J, HIS61I, ILE126I, ILE128I, ILE135I, ILE137I, ILE161I, ILE189I, ILE19I, ILE2I, ILE310J, ILE328J, ILE339J, ILE343J, ILE35I, ILE461J, ILE465J, ILE470J, ILE475J, ILE491J, ILE495J, ILE505J, ILE525J, LEU130I, LEU139I, LEU158I, LEU160I, LEU170I, LEU21I, LEU23I, LEU320J, LEU336J, LEU354J, LEU363J, LEU396J, LEU419J, LEU474J, LEU478J, LEU4I, LEU504J, LEU527J, LEU5I, LEU62I, LEU85I, LYS318J, LYS325J, LYS390J, LYS411J, LYS473J, LYS493J, MET122I, MET399J, PHE131I, PHE197I, PHE198I, PHE200I, PHE308J, PHE351J, PHE356J, PHE367J, PHE423J, PHE439J, PHE463J, PHE523J, PHE67I, PHE92I, PHE99I, PRO156I, PRO15I, PRO29I, PRO301J, PRO317J, PRO322J, PRO332J, PRO340J, PRO349J, PRO448J, PRO468J, PRO490J, PRO6I, PRO9I, SER10I, SER129I, SER327J, SER331J, SER338J, SER342J, SER344J, SER352J, SER466J, SER469J, SER494J, SER66I, SER91I, THR12I, THR141I, THR169I, THR195I, THR30I, THR321J, THR326J, THR346J, THR347J, THR472J, THR476J, THR533J, THR8I, THR98I, TRP315J, TRP36I, TRP400J, TRP449J, TRP71I, TYR144I, TYR16I, TYR324J, TYR388J, TYR415J, TYR447J, TYR479J, TYR56I, TYR79I, TYR83I, VAL113I, VAL114I, VAL120I, VAL157I, VAL17I, VAL196I, VAL309J, VAL337J, VAL384J, VAL385J, VAL397J, VAL426J, VAL492J, VAL501J, VAL526J, VAL55I, VAL63I, VAL70I
• I-K: ARG133I, ARG166K, ARG64I, ASN59I, ASP57I, ASP65I, GLN163K, GLN165K, GLU162K, GLU192K, GLY191K, GLY60I, HIS61I, LEU62I, PHE99I, PRO164K, VAL63I
• I-L: ALA335L, ARG333L, ASN59I, GLN190I, GLN334L, GLY58I, HIS61I
• J-K: ALA329J, ARG166K, ARG330J, ARG450J, ASN116K, ASN159K, ASN451J, ASN454J, ASP199K, GLN163K, GLU162K, GLU3K, GLY452J, ILE161K, ILE2K, LEU160K, LEU485J, LYS325J, MET488J, PHE197K, PHE198K, PHE200K, PRO156K, PRO1K, PRO453J, PRO484J, PRO487J, THR326J, VAL157K
• J-L: ALA329J, ALA335L, ARG311L, ARG313L, ARG333J, ARG333L, ARG450J, ARG528L, ARG531L, ASN314L, ASN451J, ASN454J, ASN537L, ASP312L, ASP323J, ASP455J, CYS538L, GLN334L, GLN341L, GLY452J, ILE310L, ILE328J, ILE339L, LEU320J, LEU320L, LEU336L, LEU416J, LYS318L, LYS325J, LYS493J, MET488J, PHE535L, PRO322J, PRO332L, PRO340L, PRO453J, PRO490J, SER327J, SER338L, THR326J, TRP449J, TRP456J, TYR324J, VAL309L, VAL337L
• K-L: ALA117K, ALA118K, ALA132K, ALA13K, ALA22K, ALA25K, ALA26K, ALA302L, ALA319L, ALA329L, ALA335L, ALA358L, ALA402L, ALA471L, ALA500L, ALA73K, ALA82K, ARG133K, ARG142K, ARG166K, ARG167K, ARG188K, ARG307L, ARG311L, ARG313L, ARG31K, ARG330L, ARG333L, ARG407L, ARG409L, ARG414L, ARG428L, ARG450L, ARG457L, ARG528L, ARG531L, ARG64K, ARG94K, ASN115K, ASN116K, ASN127K, ASN136K, ASN159K, ASN28K, ASN350L, ASN366L, ASN369L, ASN412L, ASN497L, ASN537L, ASN59K, ASN84K, ASN87K, ASN90K, ASP100K, ASP199K, ASP304L, ASP312L, ASP323L, ASP32K, ASP360L, ASP386L, ASP413L, ASP524L, ASP57K, ASP65K, ASP74K, ASP81K, CYS155K, CYS489L, GLN11K, GLN163K, GLN190K, GLN303L, GLN334L, GLN33K, GLN341L, GLN387L, GLN401L, GLN477L, GLN502L, GLN503L, GLN530L, GLN72K, GLN80K, GLU162K, GLU192K, GLU194K, GLU24K, GLU345L, GLU34K, GLU398L, GLU3K, GLU499L, GLU536L, GLU69K, GLU78K, GLU7K, GLU86K, GLY119K, GLY134K, GLY14K, GLY191K, GLY193K, GLY20K, GLY27K, GLY348L, GLY355L, GLY357L, GLY389L, GLY406L, GLY424L, GLY425L, GLY427L, GLY464L, GLY529L, GLY58K, GLY60K, GLY77K, GLY93K, HIS125K, HIS138K, HIS140K, HIS18K, HIS316L, HIS353L, HIS359L, HIS361L, HIS408L, HIS410L, HIS460L, HIS462L, HIS61K, ILE126K, ILE128K, ILE135K, ILE137K, ILE161K, ILE189K, ILE19K, ILE2K, ILE310L, ILE328L, ILE339L, ILE343L, ILE35K, ILE465L, ILE470L, ILE475L, ILE491L, ILE495L, ILE505L, ILE525L, LEU130K, LEU139K, LEU158K, LEU160K, LEU170K, LEU21K, LEU23K, LEU320L, LEU336L, LEU354L, LEU363L, LEU396L, LEU474L, LEU478L, LEU4K, LEU504L, LEU527L, LEU5K, LEU62K, LEU85K, LYS318L, LYS325L, LYS390L, LYS411L, LYS473L, LYS493L, MET122K, MET399L, PHE131K, PHE197K, PHE198K, PHE200K, PHE308L, PHE351L, PHE356L, PHE367L, PHE423L, PHE439L, PHE463L, PHE523L, PHE67K, PHE92K, PHE99K, PRO156K, PRO15K, PRO29K, PRO301L, PRO317L, PRO322L, PRO332L, PRO340L, PRO349L, PRO448L, PRO468L, PRO490L, PRO6K, PRO9K, SER10K, SER129K, SER327L, SER331L, SER338L, SER342L, SER344L, SER352L, SER466L, SER469L, SER494L, SER66K, SER91K, THR12K, THR141K, THR169K, THR195K, THR30K, THR321L, THR326L, THR346L, THR347L, THR472L, THR476L, THR533L, THR8K, THR97K, THR98K, TRP315L, TRP36K, TRP400L, TRP449L, TRP71K, TYR144K, TYR16K, TYR324L, TYR388L, TYR415L, TYR447L, TYR479L, TYR56K, TYR79K, TYR83K, VAL114K, VAL120K, VAL157K, VAL17K, VAL196K, VAL309L, VAL337L, VAL384L, VAL385L, VAL397L, VAL426L, VAL492L, VAL501L, VAL526L, VAL55K, VAL63K, VAL70K