1XN1

crystal structure of lumazine synthase from brucella abortus (orthorhombic form at 3.05 angstroms)

• Total interactions analyzed: 45
• Total true interactions: 28
• Strongest Interaction:
  • Chains: D-E
  • Int. Res.: 124
  • Norm. En. per Res.: -4.5171
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-53.9314	-43.0584	-403.756	-500.7458	128	22	10	15437	3	28	30
A-C	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	1
A-D	0.0	0.0	-0.0006	-0.0006	2	0	0	2	0	0	1
A-E	-45.8912	-41.6331	-396.091	-483.6153	125	23	8	15399	2	28	28
A-F	-4.5956	-20.1756	-93.7084	-118.4797	39	1	0	3045	0	23	38
A-J	0.0	4.7247	-59.0101	-54.2854	34	1	1	1873	1	30	37
B-C	-58.9616	-57.2598	-398.513	-514.7344	125	20	9	15484	4	28	30
B-D	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	1
B-I	-3.6915	-8.2486	-58.5534	-70.4935	33	1	1	1861	2	30	37
B-J	0.0	-22.3698	-98.5906	-120.9604	40	1	0	3105	1	23	37
C-D	-86.2564	-52.5211	-394.875	-533.6525	126	26	10	15474	4	27	30
C-E	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	1
C-H	0.0	-12.6892	-53.3891	-66.0783	36	6	1	1876	3	30	36
C-I	0.0	-21.9028	-99.1531	-121.0559	42	0	0	3198	0	22	37
D-E	-92.9216	-50.8644	-416.339	-560.125	124	19	9	15719	3	28	30
D-G	0.0	-3.467	-47.5198	-50.9868	32	8	1	1713	2	29	36
D-H	-9.5614	-19.6993	-87.5947	-116.8554	38	1	0	3009	0	22	37
E-F	0.0	7.474	-56.0776	-48.6036	33	4	1	1892	0	30	39
E-G	-2.941	-16.8172	-102.341	-122.0992	39	0	0	3132	0	24	37
F-G	-65.4217	-42.3856	-422.533	-530.3403	129	50	10	16157	3	28	28
F-I	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	1
F-J	-43.3142	-33.5587	-361.707	-438.5799	124	29	8	14840	2	29	28
G-H	-60.5499	-51.228	-391.314	-503.0918	126	22	10	15410	3	29	29
G-I	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	1
G-J	0.0	0.0	-0.0006	-0.0006	2	0	0	2	0	0	1
H-I	-60.2999	-36.812	-405.065	-502.1769	125	19	8	15606	2	29	31
H-J	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	1
I-J	-50.3141	-47.8728	-390.649	-488.8359	126	18	9	15367	4	28	29

Interface residues

• A-B: ALA130A, ALA139A, ALA140A, ALA142A, ALA143A, ALA154A, ALA155A, ALA16B, ALA20B, ALA56B, ALA63B, ALA67B, ALA73A, ALA74A, ALA79A, ALA93A, ALA93B, ALA95A, ALA95B, ARG150A, ARG152A, ARG21B, ARG68B, ARG71B, ARG88A, ARG88B, ASN98A, ASN98B, ASP52B, ASP83A, ASP83B, ASP90A, ASP90B, GLN102A, GLN102B, GLN104A, GLN104B, GLN145A, GLN19B, GLU106A, GLU106B, GLU108A, GLU138A, GLU149A, GLU49B, GLU58B, GLY55B, GLY77A, GLY84B, GLY85B, GLY99A, GLY99B, HIS119A, HIS120A, HIS129A, HIS131A, HIS141A, HIS62B, HIS89A, HIS89B, ILE146A, ILE153A, ILE18B, ILE26A, ILE50B, ILE59B, ILE75A, ILE82A, ILE82B, ILE86B, ILE97A, ILE97B, LEU105A, LEU112A, LEU116A, LEU144A, LEU61B, LEU66B, LYS133A, LYS135A, LYS64B, MET100A, MET100B, MET101A, MET101B, PHE121A, PHE127A, PHE128A, PHE132A, PHE51B, PHE80A, PHE91A, PHE91B, PRO110A, PRO118A, PRO54B, PRO60A, PRO60B, SER113A, SER148A, SER151A, THR107A, THR107B, THR117A, THR65B, THR69B, THR94A, THR94B, TRP22B, TYR57B, TYR72B, TYR87B, VAL103A, VAL103B, VAL109A, VAL111A, VAL114A, VAL115A, VAL134A, VAL137A, VAL147A, VAL53B, VAL76A, VAL81A, VAL92A, VAL92B, VAL96A, VAL96B
• A-C: ARG88C, HIS119A
• A-D: ARG88A, HIS119D
• A-E: ALA130E, ALA139E, ALA140E, ALA142E, ALA143E, ALA16A, ALA20A, ALA56A, ALA63A, ALA73E, ALA74E, ALA79E, ALA93A, ALA93E, ALA95A, ALA95E, ARG150E, ARG152E, ARG21A, ARG68A, ARG71A, ARG88A, ARG88E, ASN98A, ASN98E, ASP52A, ASP83A, ASP83E, ASP90A, ASP90E, GLN102A, GLN102E, GLN104E, GLN145E, GLN19A, GLU106A, GLU106E, GLU108E, GLU138E, GLU149E, GLU49A, GLU58A, GLY55A, GLY77E, GLY84A, GLY85A, GLY99A, GLY99E, HIS119E, HIS120E, HIS129E, HIS131E, HIS141E, HIS62A, HIS89A, HIS89E, ILE146E, ILE153E, ILE18A, ILE26E, ILE50A, ILE59A, ILE75E, ILE82A, ILE82E, ILE86A, ILE97A, ILE97E, LEU105E, LEU112E, LEU116E, LEU144E, LEU61A, LEU66A, LYS133E, LYS135E, LYS64A, MET100A, MET100E, MET101A, MET101E, PHE121E, PHE127E, PHE128E, PHE132E, PHE17A, PHE51A, PHE80E, PHE91A, PHE91E, PRO110E, PRO118E, PRO54A, PRO60A, PRO60E, SER113E, SER148E, SER151E, THR107A, THR107E, THR117E, THR65A, THR69A, THR94A, THR94E, TRP22A, TYR57A, TYR72A, TYR87A, VAL103A, VAL103E, VAL109E, VAL111E, VAL114E, VAL115E, VAL134E, VAL137E, VAL147E, VAL53A, VAL76E, VAL81E, VAL92A, VAL92E, VAL96A, VAL96E
• A-F: ARG88A, ARG88F, ASP83A, ASP83F, GLU121A, GLU121F, GLU123A, GLU123F, GLY84A, GLY84F, GLY85A, GLY85F, HIS119A, HIS119F, HIS120A, HIS120F, HIS121A, HIS121F, HIS124A, HIS124F, HIS125A, HIS125F, HIS89A, HIS89F, ILE82A, ILE82F, ILE86A, ILE86F, LYS122A, LYS122F, PHE121A, PHE121F, PHE127F, PHE128A, PHE128F, SER121A, SER121F, TYR87A, TYR87F
• A-J: ALA130A, ALA130J, ASP126A, ASP126J, GLU123A, GLU123J, GLU138A, GLU138J, HIS119A, HIS119J, HIS120A, HIS120J, HIS121A, HIS121J, HIS124A, HIS124J, HIS125A, HIS125J, HIS131A, HIS131J, LYS122A, LYS122J, LYS135A, LYS135J, PHE121J, PHE127A, PHE127J, PHE128A, PHE128J, PRO118J, SER121A, SER121J, VAL134A, VAL134J
• B-C: ALA130B, ALA139B, ALA142B, ALA143B, ALA154B, ALA155B, ALA16C, ALA20C, ALA30B, ALA56C, ALA63C, ALA67C, ALA73B, ALA74B, ALA93B, ALA93C, ALA95B, ALA95C, ARG150B, ARG152B, ARG21C, ARG68C, ARG71C, ARG88B, ARG88C, ASN98B, ASN98C, ASP52C, ASP83B, ASP83C, ASP90B, ASP90C, GLN102B, GLN102C, GLN104B, GLN145B, GLN19C, GLU106B, GLU106C, GLU108B, GLU138B, GLU149B, GLU49C, GLU58C, GLY136B, GLY55C, GLY77B, GLY84C, GLY85C, GLY99B, GLY99C, HIS119B, HIS120B, HIS129B, HIS131B, HIS141B, HIS62C, HIS89B, HIS89C, ILE146B, ILE153B, ILE18C, ILE26B, ILE50C, ILE59C, ILE75B, ILE82B, ILE82C, ILE86C, ILE97B, ILE97C, LEU105B, LEU112B, LEU116B, LEU144B, LEU61C, LEU66C, LYS133B, LYS135B, LYS64C, MET100B, MET100C, MET101B, PHE121B, PHE127B, PHE128B, PHE132B, PHE51C, PHE80B, PHE91B, PHE91C, PRO110B, PRO118B, PRO54C, PRO60B, PRO60C, SER113B, SER148B, SER151B, THR107B, THR107C, THR117B, THR65C, THR69C, THR94B, THR94C, TRP22C, TYR57C, TYR72C, TYR87C, VAL103B, VAL103C, VAL109B, VAL111B, VAL114B, VAL115B, VAL134B, VAL147B, VAL53C, VAL76B, VAL81B, VAL92B, VAL92C, VAL96B, VAL96C
• B-D: ARG88D, HIS119B
• B-I: ALA130B, ALA130I, ASP126B, ASP126I, GLU123B, GLU123I, GLU138B, GLU138I, HIS119B, HIS119I, HIS120B, HIS120I, HIS121B, HIS121I, HIS124B, HIS124I, HIS125B, HIS125I, HIS131B, HIS131I, LYS122B, LYS122I, LYS135B, LYS135I, PHE121B, PHE127B, PHE127I, PHE128B, PHE128I, SER121B, SER121I, VAL134B, VAL134I
• B-J: ARG88B, ARG88J, ASP83B, ASP83J, GLU121B, GLU121J, GLU123B, GLU123J, GLY84B, GLY84J, GLY85B, GLY85J, HIS119B, HIS119J, HIS120B, HIS120J, HIS121B, HIS121J, HIS124B, HIS124J, HIS125B, HIS125J, HIS89B, HIS89J, ILE82B, ILE82J, ILE86B, ILE86J, LYS122B, LYS122J, PHE121B, PHE121J, PHE127B, PHE127J, PHE128B, PHE128J, SER121B, SER121J, TYR87B, TYR87J
• C-D: ALA130C, ALA139C, ALA142C, ALA143C, ALA154C, ALA16D, ALA20D, ALA30C, ALA56D, ALA63D, ALA67D, ALA73C, ALA74C, ALA79C, ALA93C, ALA93D, ALA95C, ALA95D, ARG150C, ARG152C, ARG21D, ARG68D, ARG71D, ARG88C, ARG88D, ASN98C, ASN98D, ASP52D, ASP83C, ASP83D, ASP90C, ASP90D, GLN102C, GLN102D, GLN104C, GLN104D, GLN145C, GLN19D, GLU106C, GLU106D, GLU108C, GLU138C, GLU149C, GLU49D, GLU58D, GLY136C, GLY55D, GLY77C, GLY84D, GLY85D, GLY99C, GLY99D, HIS119C, HIS120C, HIS131C, HIS141C, HIS62D, HIS89C, HIS89D, ILE146C, ILE153C, ILE18D, ILE26C, ILE50D, ILE59D, ILE75C, ILE82C, ILE82D, ILE86D, ILE97C, ILE97D, LEU105C, LEU112C, LEU116C, LEU144C, LEU61D, LEU66D, LYS133C, LYS135C, LYS64D, MET100C, MET100D, MET101C, MET101D, PHE121C, PHE127C, PHE128C, PHE132C, PHE51D, PHE80C, PHE91C, PHE91D, PRO110C, PRO118C, PRO54D, PRO60C, PRO60D, SER113C, SER148C, SER151C, THR107C, THR107D, THR117C, THR65D, THR69D, THR94C, THR94D, TRP22D, TYR57D, TYR72D, TYR87D, VAL103C, VAL103D, VAL109C, VAL111C, VAL114C, VAL115C, VAL134C, VAL147C, VAL53D, VAL76C, VAL81C, VAL92C, VAL92D, VAL96C, VAL96D
• C-E: ARG88E, HIS119C
• C-H: ALA130C, ALA130H, ASP126C, ASP126H, GLU123C, GLU123H, GLU138C, GLU138H, HIS119C, HIS119H, HIS120C, HIS120H, HIS121C, HIS121H, HIS124C, HIS124H, HIS125C, HIS125H, HIS131C, HIS131H, LYS122C, LYS122H, LYS135C, LYS135H, PHE121C, PHE121H, PHE127C, PHE127H, PHE128C, PHE128H, PRO118C, PRO118H, SER121C, SER121H, VAL134C, VAL134H
• C-I: ARG88C, ARG88I, ASP83C, ASP83I, GLU121C, GLU121I, GLU123C, GLU123I, GLY84C, GLY84I, GLY85C, GLY85I, HIS119C, HIS119I, HIS120C, HIS120I, HIS121C, HIS121I, HIS124C, HIS124I, HIS125C, HIS125I, HIS23C, HIS89C, HIS89I, ILE82C, ILE82I, ILE86C, ILE86I, LYS122C, LYS122I, PHE121C, PHE121I, PHE127C, PHE127I, PHE128C, PHE128I, PRO118C, SER121C, SER121I, TYR87C, TYR87I
• D-E: ALA130D, ALA139D, ALA142D, ALA143D, ALA154D, ALA16E, ALA20E, ALA30D, ALA56E, ALA63E, ALA67E, ALA74D, ALA93D, ALA93E, ALA95D, ALA95E, ARG150D, ARG152D, ARG21E, ARG68E, ARG71E, ARG88D, ARG88E, ASN98D, ASN98E, ASP52E, ASP83D, ASP83E, ASP90D, ASP90E, GLN102D, GLN102E, GLN104D, GLN145D, GLN19E, GLU106D, GLU106E, GLU108D, GLU138D, GLU149D, GLU49E, GLU58E, GLY55E, GLY77D, GLY84E, GLY85E, GLY99D, GLY99E, HIS119D, HIS120D, HIS129D, HIS131D, HIS141D, HIS62E, HIS89D, HIS89E, ILE146D, ILE153D, ILE18E, ILE26D, ILE50E, ILE59E, ILE75D, ILE82D, ILE82E, ILE86E, ILE97D, ILE97E, LEU105D, LEU112D, LEU116D, LEU144D, LEU61E, LEU66E, LYS133D, LYS135D, LYS64E, MET100D, MET100E, MET101D, MET101E, PHE121D, PHE127D, PHE128D, PHE132D, PHE51E, PHE80D, PHE91D, PHE91E, PRO110D, PRO118D, PRO54E, PRO60D, PRO60E, SER113D, SER148D, SER151D, THR107D, THR107E, THR117D, THR65E, THR69E, THR94D, THR94E, TRP22E, TYR57E, TYR72E, TYR87E, VAL103D, VAL103E, VAL109D, VAL111D, VAL114D, VAL115D, VAL134D, VAL137D, VAL147D, VAL53E, VAL76D, VAL81D, VAL92D, VAL92E, VAL96D, VAL96E
• D-G: ASP126D, ASP126G, GLU123D, GLU123G, GLU138D, GLU138G, HIS119D, HIS119G, HIS120D, HIS120G, HIS121D, HIS121G, HIS124D, HIS124G, HIS125G, HIS131D, HIS131G, LYS122D, LYS122G, LYS135D, LYS135G, PHE121G, PHE127D, PHE127G, PHE128D, PHE128G, PRO118D, PRO118G, SER121D, SER121G, VAL134D, VAL134G
• D-H: ARG88D, ARG88H, ASP83D, ASP83H, GLU121D, GLU121H, GLU123D, GLU123H, GLY84D, GLY84H, GLY85D, GLY85H, HIS119D, HIS119H, HIS120D, HIS120H, HIS121D, HIS121H, HIS124D, HIS124H, HIS125H, HIS23H, HIS89D, HIS89H, ILE82D, ILE82H, ILE86D, ILE86H, LYS122D, LYS122H, PHE121D, PHE121H, PHE127H, PHE128D, SER121D, SER121H, TYR87D, TYR87H
• E-F: ALA130E, ALA130F, ASP126E, ASP126F, GLU123E, GLU123F, HIS119E, HIS119F, HIS120E, HIS120F, HIS121E, HIS121F, HIS124E, HIS124F, HIS125E, HIS125F, HIS131E, HIS131F, LYS122E, LYS122F, LYS135E, LYS135F, PHE121E, PHE121F, PHE127E, PHE127F, PHE128E, PHE128F, PRO118E, SER121E, SER121F, VAL134E, VAL134F
• E-G: ARG88E, ARG88G, ASP83E, ASP83G, GLU121E, GLU121G, GLU123E, GLU123G, GLY84E, GLY84G, GLY85E, GLY85G, HIS119E, HIS119G, HIS120E, HIS120G, HIS121E, HIS121G, HIS124E, HIS124G, HIS125E, HIS23G, HIS89E, HIS89G, ILE82E, ILE82G, ILE86E, ILE86G, LYS122E, LYS122G, PHE121E, PHE121G, PHE127E, PHE128E, PHE128G, SER121E, SER121G, TYR87E, TYR87G
• F-G: ALA130F, ALA139F, ALA142F, ALA143F, ALA154F, ALA155F, ALA16G, ALA20G, ALA30F, ALA56G, ALA63G, ALA67G, ALA73F, ALA74F, ALA79F, ALA93F, ALA93G, ALA95F, ALA95G, ARG150F, ARG152F, ARG21G, ARG68G, ARG71G, ARG88F, ARG88G, ASN98F, ASN98G, ASP52G, ASP83F, ASP83G, ASP90F, ASP90G, GLN102F, GLN102G, GLN104F, GLN104G, GLN145F, GLN19G, GLU106F, GLU106G, GLU108F, GLU138F, GLU149F, GLU49G, GLU58G, GLY136F, GLY55G, GLY77F, GLY84G, GLY85G, GLY99F, GLY99G, HIS119F, HIS120F, HIS131F, HIS141F, HIS62G, HIS89F, HIS89G, ILE146F, ILE153F, ILE18G, ILE26F, ILE50G, ILE59F, ILE59G, ILE75F, ILE82F, ILE82G, ILE86G, ILE97F, ILE97G, LEU105F, LEU112F, LEU116F, LEU144F, LEU61G, LEU66G, LYS133F, LYS135F, LYS64G, MET100F, MET100G, MET101F, MET101G, PHE121F, PHE127F, PHE128F, PHE132F, PHE51G, PHE80F, PHE91F, PHE91G, PRO110F, PRO118F, PRO54G, PRO60F, PRO60G, SER113F, SER148F, SER151F, THR107F, THR107G, THR117F, THR65G, THR69G, THR94F, THR94G, TRP22G, TYR57G, TYR72G, TYR87G, VAL103F, VAL103G, VAL109F, VAL111F, VAL114F, VAL115F, VAL134F, VAL137F, VAL147F, VAL53G, VAL76F, VAL81F, VAL92F, VAL92G, VAL96F, VAL96G
• F-I: ARG88F, HIS119I
• F-J: ALA130J, ALA139J, ALA140J, ALA142J, ALA143J, ALA20F, ALA30J, ALA56F, ALA63F, ALA73J, ALA74J, ALA79J, ALA93F, ALA93J, ALA95F, ALA95J, ARG150J, ARG152J, ARG21F, ARG68F, ARG71F, ARG88F, ARG88J, ASN98F, ASN98J, ASP52F, ASP83F, ASP83J, ASP90F, ASP90J, GLN102F, GLN102J, GLN104F, GLN104J, GLN145J, GLN19F, GLU106F, GLU106J, GLU108J, GLU138J, GLU149J, GLU49F, GLU58F, GLY136J, GLY55F, GLY77J, GLY84F, GLY85F, GLY99F, GLY99J, HIS119J, HIS120J, HIS131J, HIS141J, HIS62F, HIS89F, HIS89J, ILE146J, ILE153J, ILE18F, ILE26J, ILE50F, ILE59F, ILE75J, ILE82F, ILE82J, ILE86F, ILE97F, ILE97J, LEU105J, LEU112J, LEU116J, LEU144J, LEU61F, LEU66F, LYS133J, LYS135J, LYS64F, MET100F, MET100J, MET101F, MET101J, PHE121J, PHE127J, PHE128J, PHE132J, PHE51F, PHE80J, PHE91F, PHE91J, PRO110J, PRO118J, PRO54F, PRO60F, PRO60J, SER113J, SER148J, SER151J, THR107F, THR107J, THR117J, THR65F, THR69F, THR94F, THR94J, TRP22F, TYR57F, TYR72F, TYR87F, VAL103F, VAL103J, VAL109J, VAL111J, VAL114J, VAL115J, VAL134J, VAL147J, VAL53F, VAL76J, VAL81J, VAL92F, VAL92J, VAL96F, VAL96J
• G-H: ALA130G, ALA139G, ALA142G, ALA143G, ALA154G, ALA155G, ALA16H, ALA30G, ALA56H, ALA63H, ALA67H, ALA74G, ALA79G, ALA93G, ALA93H, ALA95G, ALA95H, ARG150G, ARG152G, ARG21H, ARG68H, ARG71H, ARG88G, ARG88H, ASN98G, ASN98H, ASP52H, ASP83G, ASP83H, ASP90G, ASP90H, GLN102G, GLN102H, GLN104G, GLN104H, GLN145G, GLN19H, GLU106G, GLU106H, GLU108G, GLU138G, GLU149G, GLU49H, GLU58H, GLY136G, GLY55H, GLY77G, GLY84H, GLY85H, GLY99G, GLY99H, HIS119G, HIS120G, HIS131G, HIS141G, HIS62H, HIS89G, HIS89H, ILE146G, ILE153G, ILE18H, ILE26G, ILE50H, ILE59H, ILE75G, ILE82G, ILE82H, ILE86H, ILE97G, ILE97H, LEU105G, LEU112G, LEU116G, LEU144G, LEU61H, LEU66H, LYS133G, LYS135G, LYS64H, MET100G, MET100H, MET101G, MET101H, PHE121G, PHE127G, PHE128G, PHE132G, PHE51H, PHE80G, PHE91G, PHE91H, PRO110G, PRO118G, PRO54H, PRO60G, PRO60H, SER113G, SER148G, SER151G, THR107G, THR107H, THR117G, THR65H, THR69H, THR94G, THR94H, TRP22H, TYR57H, TYR72H, TYR87H, VAL103G, VAL103H, VAL109G, VAL111G, VAL114G, VAL115G, VAL134G, VAL137G, VAL147G, VAL53H, VAL76G, VAL81G, VAL92G, VAL92H, VAL96G, VAL96H
• G-I: ARG88I, HIS119G
• G-J: ARG88G, HIS119J
• H-I: ALA130H, ALA139H, ALA140H, ALA142H, ALA143H, ALA154H, ALA20I, ALA56I, ALA63I, ALA73H, ALA74H, ALA79H, ALA93H, ALA93I, ALA95H, ALA95I, ARG150H, ARG152H, ARG21I, ARG68I, ARG71I, ARG88H, ARG88I, ASN98H, ASN98I, ASP52I, ASP83H, ASP83I, ASP90H, ASP90I, GLN102H, GLN102I, GLN104H, GLN104I, GLN145H, GLN19I, GLU106H, GLU106I, GLU108H, GLU138H, GLU149H, GLU49I, GLU58I, GLY55I, GLY77H, GLY84I, GLY85I, GLY99H, GLY99I, HIS119H, HIS120H, HIS129H, HIS131H, HIS141H, HIS62I, HIS89H, HIS89I, ILE146H, ILE153H, ILE18I, ILE26H, ILE50I, ILE59I, ILE75H, ILE82H, ILE82I, ILE86I, ILE97H, ILE97I, LEU105H, LEU112H, LEU116H, LEU144H, LEU61I, LEU66I, LYS133H, LYS135H, LYS64I, MET100H, MET100I, MET101H, MET101I, PHE121H, PHE127H, PHE128H, PHE132H, PHE51I, PHE80H, PHE91H, PHE91I, PRO110H, PRO118H, PRO54I, PRO60H, PRO60I, SER113H, SER148H, SER151H, THR107H, THR107I, THR117H, THR65I, THR69I, THR94H, THR94I, TRP22I, TYR57I, TYR72I, TYR87I, VAL103H, VAL103I, VAL109H, VAL111H, VAL114H, VAL115H, VAL134H, VAL137H, VAL147H, VAL53I, VAL76H, VAL81H, VAL92H, VAL92I, VAL96H, VAL96I
• H-J: ARG88J, HIS119H
• I-J: ALA130I, ALA139I, ALA142I, ALA143I, ALA154I, ALA155I, ALA16J, ALA20J, ALA56J, ALA63J, ALA67J, ALA73I, ALA74I, ALA79I, ALA93I, ALA93J, ALA95I, ALA95J, ARG150I, ARG152I, ARG21J, ARG68J, ARG71J, ARG88I, ARG88J, ASN98I, ASN98J, ASP52J, ASP83I, ASP83J, ASP90I, ASP90J, GLN102I, GLN102J, GLN104I, GLN104J, GLN145I, GLN19J, GLU106I, GLU106J, GLU108I, GLU138I, GLU149I, GLU49J, GLU58J, GLY55J, GLY77I, GLY84J, GLY85J, GLY99I, GLY99J, HIS119I, HIS120I, HIS129I, HIS131I, HIS141I, HIS62J, HIS89I, HIS89J, ILE146I, ILE153I, ILE18J, ILE26I, ILE50J, ILE59J, ILE75I, ILE82I, ILE82J, ILE86J, ILE97I, ILE97J, LEU105I, LEU112I, LEU116I, LEU144I, LEU61J, LEU66J, LYS133I, LYS135I, LYS64J, MET100I, MET100J, MET101I, MET101J, PHE121I, PHE127I, PHE128I, PHE132I, PHE51J, PHE80I, PHE91I, PHE91J, PRO110I, PRO118I, PRO54J, PRO60I, PRO60J, SER113I, SER148I, SER151I, THR107I, THR107J, THR117I, THR65J, THR69J, THR94I, THR94J, TRP22J, TYR57J, TYR72J, TYR87J, VAL103I, VAL103J, VAL109I, VAL111I, VAL114I, VAL115I, VAL134I, VAL147I, VAL53J, VAL76I, VAL81I, VAL92I, VAL92J, VAL96I, VAL96J