1XFB

human brain fructose 1,6-(bis)phosphate aldolase (c isozyme)

• Total interactions analyzed: 66
• Total true interactions: 26
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 122
  • Norm. En. per Res.: -3.2124
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-64.6965	-24.8744	-270.755	-360.3259	127	36	4	11544	2	38	25
A-C	0.0	9.9438	-18.7148	-8.7709	32	0	1	952	0	8	11
A-D	-45.9702	-24.6208	-278.409	-349.0	133	21	0	11583	2	29	47
A-E	0.0	16.3806	-2.0639	14.3168	12	0	0	182	0	9	4
A-H	-29.3134	-18.222	147.787	100.2516	38	25	0	2239	0	10	9
A-I	-14.4898	19.4354	-43.4281	-38.4825	43	9	0	2453	3	24	25
B-C	-39.283	-16.6321	-256.564	-312.4791	124	21	0	11305	2	28	46
B-D	0.0	11.821	-22.0007	-10.1797	32	0	1	998	0	8	11
C-D	-67.5306	-22.8656	-301.518	-391.9142	122	31	3	11768	2	38	24
C-L	0.0	19.8246	-19.019	0.8056	30	0	0	1809	0	9	8
D-I	0.0	5.2951	-1.0554	4.2397	10	0	0	147	0	5	2
E-F	-76.012	-20.1137	-302.168	-398.2937	125	23	3	11590	2	40	24
E-G	-14.0976	19.3278	-21.4436	-16.2133	32	7	1	1295	0	10	11
E-H	-47.5368	-15.2103	-268.867	-331.614	131	24	0	11941	2	29	46
F-G	-62.3375	-11.9149	-300.254	-374.5063	130	31	0	12303	2	30	46
F-H	-12.8875	14.145	-25.5994	-24.3418	32	1	1	1115	0	8	11
F-J	-2.6628	14.5777	346.388	358.303	29	40	0	1468	0	18	13
G-H	-67.1922	-19.0283	-265.053	-351.2735	122	32	4	11109	2	39	24
G-J	0.0	0.0	-0.0215	-0.0215	3	0	0	11	0	0	0
H-J	0.0	1.5947	-15.2313	-13.6366	30	0	1	1048	0	14	7
I-J	-53.7113	-19.3372	-271.413	-344.4615	119	19	3	10779	2	38	24
I-K	-9.19	23.0761	79.7346	93.6208	32	19	1	1508	0	10	11
I-L	-51.9684	-6.7215	-282.98	-341.6699	128	38	0	12473	2	30	47
J-K	-65.1152	-14.0429	-284.694	-363.8521	130	32	0	12274	2	29	46
J-L	-14.0142	17.7565	-28.7543	-25.0121	32	2	1	1223	0	9	11
K-L	-72.7222	-16.8371	-303.173	-392.7323	125	32	3	11643	2	38	24

Interface residues

• A-B: ALA117A, ALA117B, ALA161A, ALA161B, ALA163A, ALA163B, ALA168A, ALA168B, ALA172A, ALA172B, ALA175A, ALA175B, ALA216A, ALA216B, ALA7A, ALA7B, ARG134A, ARG134B, ARG157A, ARG157B, ARG173A, ARG173B, ASN167A, ASN167B, ASN169A, ASN169B, ASN181A, ASN181B, ASP110A, ASP110B, ASP120A, ASP120B, ASP129A, ASP129B, ASP219A, ASP219B, CB5.5896439.73004, CB9.89235-6.18158, CYS178A, GLN126A, GLN126B, GLN179A, GLN179B, GLN180A, GLN180B, GLU122A, GLU122B, GLU133A, GLU133B, GLU156A, GLU156B, GLU166A, GLU166B, GLY112A, GLY112B, GLY118A, GLY118B, GLY121A, GLY121B, GLY127A, GLY127B, GLY130A, GLY130B, HIS220A, HIS220B, HIS221A, HIS221B, HIS3A, HIS3A5, HIS3B, ILE177A, ILE177B, LEU116A, LEU116B, LEU128A, LEU128B, LEU131A, LEU131B, LEU162A, LEU162B, LEU165A, LEU165B, LEU217A, LEU217B, LEU8A, LEU8B, LYS111A, LYS111B, LYS153B, LYS215A, LYS215B, PRO115A, PRO115B, PRO6A, PRO6B, SER132A, SER132B, SER155A, SER155B, SER160A, SER160B, SER176A, SER176B, SER218A, SER218B, SER4A, SER4B, THR119A, THR119B, THR123A, THR123B, THR124A, THR124B, THR125A, THR125B, THR158A, THR158B, TRP148A, TRP148B, TYR5A, TYR5B, VAL114A, VAL114B, VAL170A, VAL170B, VAL222A, VAL222B
• A-C: ALA161A, ALA161C, ARG157A, ARG157C, ARG201A, ARG201C, GLU156A, GLU156C, GLY118A, GLY118C, ILE154A, ILE154C, ILE164A, ILE164C, LEU162A, LEU162C, LYS208A, LYS208C, PRO159A, PRO159C, SER155A, SER155C, SER160A, SER160C, THR119A, THR119C, THR158A, THR158C, TYR204A, TYR204C, VAL205A, VAL205C
• A-D: ALA10A, ALA161A, ALA161D, ALA168D, ALA211A, ALA211D, ALA212A, ALA212D, ALA216A, ALA216D, ALA256A, ALA256D, ALA264A, ALA264D, ALA7A, ALA7D, ARG157A, ARG157D, ARG201A, ARG201D, ARG258A, ARG258D, ARG259A, ARG259D, ARG294A, ARG294D, ASP198A, ASP198D, ASP219A, ASP219D, CB8.172602.21848, CB8.175542.37111, CB9.2225391.56585, CYS202A, CYS202D, GLN203A, GLN203D, GLU156A, GLU156D, GLU207A, GLU207D, GLU225A, GLU225D, GLY226A, HIS220A, HIS220D, HIS221A, HIS221D, HIS3A, HIS3A5, HIS3D, ILE154A, ILE154D, ILE164A, ILE164D, LEU165A, LEU165D, LEU210A, LEU210D, LEU217A, LEU217D, LEU21A, LEU224A, LEU224D, LEU257A, LEU257D, LEU292A, LEU292D, LEU8A, LYS13A, LYS13D, LYS14A, LYS153D, LYS200A, LYS200D, LYS208A, LYS208D, LYS215A, LYS215D, PRO159A, PRO159D, PRO262A, PRO262D, PRO263A, PRO263D, PRO266A, PRO266D, PRO293A, PRO293D, PRO295A, PRO295D, PRO6A, PRO6D, SER155A, SER155D, SER160A, SER160D, SER17A, SER218A, SER218D, SER4A, SER4D, SER9A, THR158A, THR158D, THR255A, THR255D, THR260A, THR260D, TRP296A, TRP296D, TYR204A, TYR204D, TYR214A, TYR214D, TYR223A, TYR223D, TYR5A, TYR5D, VAL205A, VAL205D, VAL209A, VAL209D, VAL213A, VAL213D, VAL222A, VAL222D, VAL254A, VAL254D, VAL261A, VAL261D, VAL265A, VAL265D
• A-E: ARG22E, ASP18E, GLU50A, GLU54A, GLY48A, LEU21E, LYS14E, PRO26E, SER17E, SER45A, THR52A, VAL49A
• A-H: ALA250H, ALA286H, ALA313A, ALA323A, ALA324A, ARG258H, ARG289H, ARG294H, ARG315A, ARG318A, ASN288H, ASN312A, ASN320A, ASP319A, CYS290H, GLN317A, GLN340H, GLN46A, GLU247H, GLU326A, GLU327A, GLU344H, GLY316A, GLY341H, GLY48A, ILE287H, ILE47A, LEU292H, LEU311A, LYS330A, LYS342H, MET251H, PRO291H, PRO293H, SER309A, THR245H, TRP314A, VAL49A
• A-I: ALA143I, ALA239A, ARG22I, ARG96I, ASP100I, ASP141I, ASP144I, ASP18I, ASP196A, ASP198A, ASP68I, CYS240A, GLN137I, GLN99I, GLU156A, GLU15I, GLU248A, GLY102I, GLY142I, ILE103I, ILE19I, ILE242A, ILE249A, ILE98I, LEU199A, LYS101I, LYS139I, LYS140I, LYS200A, LYS243A, LYS71I, PRO236A, PRO241A, PRO93I, THR245A, THR97I, TYR138I, TYR244A, TYR85I, VAL104I, VAL105I, VAL92I, VAL95I
• B-C: ALA161B, ALA161C, ALA211B, ALA211C, ALA212B, ALA212C, ALA216B, ALA216C, ALA256B, ALA256C, ALA264B, ALA264C, ALA7B, ALA7C, ARG157B, ARG157C, ARG201B, ARG201C, ARG258B, ARG258C, ARG259B, ARG259C, ARG294B, ARG294C, ASP198C, ASP219B, ASP219C, CYS202B, CYS202C, GLN203B, GLN203C, GLU156B, GLU156C, GLU207B, GLU207C, GLU225B, GLU225C, HIS220B, HIS220C, HIS221B, HIS221C, HIS3B, HIS3C, ILE154B, ILE154C, ILE164B, ILE164C, LEU165B, LEU165C, LEU210B, LEU210C, LEU217B, LEU217C, LEU224B, LEU224C, LEU257B, LEU257C, LEU292B, LEU292C, LEU8B, LEU8C, LYS13B, LYS13C, LYS14B, LYS14C, LYS200B, LYS200C, LYS208B, LYS208C, LYS215B, LYS215C, PRO159B, PRO159C, PRO262B, PRO262C, PRO263B, PRO263C, PRO266B, PRO266C, PRO293B, PRO293C, PRO295B, PRO295C, PRO6B, PRO6C, SER155B, SER155C, SER160B, SER160C, SER17C, SER218B, SER218C, SER4B, SER4C, THR158B, THR158C, THR255B, THR255C, THR260B, THR260C, TRP296B, TRP296C, TYR204B, TYR204C, TYR214B, TYR214C, TYR223B, TYR223C, TYR5B, TYR5C, VAL205B, VAL205C, VAL209B, VAL209C, VAL213B, VAL213C, VAL222B, VAL222C, VAL254B, VAL254C, VAL261B, VAL261C, VAL265B, VAL265C
• B-D: ALA161B, ALA161D, ARG157B, ARG157D, ARG201B, ARG201D, GLU156B, GLU156D, GLY118B, GLY118D, ILE154B, ILE154D, ILE164B, ILE164D, LEU162B, LEU162D, LYS208B, LYS208D, PRO159B, PRO159D, SER155B, SER155D, SER160B, SER160D, THR119B, THR119D, THR158B, THR158D, TYR204B, TYR204D, VAL205B, VAL205D
• C-D: ALA117C, ALA117D, ALA161C, ALA161D, ALA163C, ALA163D, ALA168C, ALA168D, ALA172C, ALA172D, ALA175C, ALA175D, ALA216C, ALA216D, ALA7C, ALA7D, ARG134C, ARG134D, ARG157C, ARG157D, ARG173C, ARG173D, ASN167C, ASN167D, ASN169C, ASN169D, ASN181C, ASP110C, ASP110D, ASP120C, ASP120D, ASP129C, ASP129D, ASP219C, ASP219D, GLN126C, GLN126D, GLN179C, GLN179D, GLN180C, GLN180D, GLU122C, GLU122D, GLU133C, GLU133D, GLU156C, GLU156D, GLU166C, GLU166D, GLY118C, GLY118D, GLY121C, GLY121D, GLY127C, GLY127D, GLY130C, GLY130D, HIS220C, HIS220D, HIS221C, HIS221D, HIS3C, HIS3D, ILE177C, ILE177D, LEU116C, LEU116D, LEU128C, LEU128D, LEU131C, LEU131D, LEU162C, LEU162D, LEU165C, LEU165D, LEU217C, LEU217D, LEU8C, LEU8D, LYS111C, LYS111D, LYS153C, LYS153D, LYS215C, LYS215D, PRO115C, PRO115D, PRO6C, PRO6D, SER132C, SER132D, SER155C, SER155D, SER160C, SER160D, SER176C, SER176D, SER218C, SER218D, SER4C, SER4D, THR119C, THR119D, THR123C, THR123D, THR124C, THR124D, THR125C, THR125D, THR158C, THR158D, TRP148C, TRP148D, TYR5C, TYR5D, VAL113C, VAL114C, VAL114D, VAL170C, VAL170D, VAL222C, VAL222D
• C-L: ALA297L, ALA339L, ARG289L, ARG294L, ASN288L, ASP196C, ASP198C, CYS240C, CYS290L, GLN340L, GLU247C, GLU248C, GLU344L, GLY27L, GLY341L, ILE242C, LEU292L, LEU298L, LEU337L, LYS200C, LYS243C, LYS342L, PRO241C, PRO246C, PRO26L, PRO291L, PRO293L, THR245C, TYR244C, TYR343L
• D-I: ALA10D, ASP67I, ASP68I, GLU11D, LEU8D, LYS71I, PRO6D, SER4D, SER9D, TYR5D
• E-F: ALA117E, ALA117F, ALA161E, ALA161F, ALA163E, ALA163F, ALA168E, ALA168F, ALA172E, ALA172F, ALA175E, ALA175F, ALA216E, ALA216F, ALA7E, ALA7F, ARG134E, ARG134F, ARG157E, ARG157F, ARG173E, ARG173F, ASN167E, ASN167F, ASN169E, ASN169F, ASP110E, ASP110F, ASP120E, ASP120F, ASP129E, ASP129F, ASP219E, ASP219F, GLN126E, GLN126F, GLN179E, GLN179F, GLN180E, GLN180F, GLU122E, GLU122F, GLU133E, GLU133F, GLU156E, GLU156F, GLU166E, GLU166F, GLY112E, GLY112F, GLY118E, GLY118F, GLY121E, GLY121F, GLY127E, GLY127F, GLY130E, GLY130F, HIS220E, HIS220F, HIS221E, HIS221F, HIS3E, HIS3F, ILE177E, ILE177F, LEU116E, LEU116F, LEU128E, LEU128F, LEU131E, LEU131F, LEU162E, LEU162F, LEU165E, LEU165F, LEU217E, LEU217F, LEU8E, LEU8F, LYS111E, LYS111F, LYS153E, LYS215E, LYS215F, PRO115E, PRO115F, PRO6E, PRO6F, SER132E, SER132F, SER155E, SER155F, SER160E, SER160F, SER176E, SER176F, SER218E, SER218F, SER4E, SER4F, THR119E, THR119F, THR123E, THR123F, THR124E, THR124F, THR125E, THR125F, THR158E, THR158F, TRP148E, TRP148F, TYR5E, TYR5F, VAL109E, VAL109F, VAL113E, VAL113F, VAL114E, VAL114F, VAL170E, VAL170F, VAL222E, VAL222F
• E-G: ALA161E, ALA161G, ARG157E, ARG157G, ARG201E, ARG201G, GLU156E, GLU156G, GLY118E, GLY118G, ILE154E, ILE154G, ILE164E, ILE164G, LEU162E, LEU162G, LYS208E, LYS208G, PRO159E, PRO159G, SER155E, SER155G, SER160E, SER160G, THR119E, THR119G, THR158E, THR158G, TYR204E, TYR204G, VAL205E, VAL205G
• E-H: ALA10H, ALA161E, ALA168E, ALA168H, ALA211E, ALA211H, ALA212E, ALA212H, ALA216E, ALA216H, ALA256E, ALA256H, ALA264E, ALA264H, ALA7E, ALA7H, ARG157E, ARG157H, ARG201E, ARG201H, ARG258E, ARG258H, ARG259E, ARG259H, ARG294E, ARG294H, ASP198E, ASP219E, ASP219H, CYS202E, CYS202H, GLN203E, GLN203H, GLU156E, GLU156H, GLU207E, GLU207H, GLU225E, GLU225H, GLY226H, HIS220E, HIS220H, HIS221E, HIS221H, HIS3E, HIS3H, ILE154E, ILE154H, ILE164E, ILE164H, LEU165E, LEU165H, LEU210E, LEU210H, LEU217E, LEU217H, LEU21H, LEU224E, LEU224H, LEU257E, LEU257H, LEU292E, LEU292H, LEU8E, LEU8H, LYS13E, LYS13H, LYS14H, LYS153E, LYS153H, LYS200E, LYS200H, LYS208E, LYS208H, LYS215E, LYS215H, PRO159E, PRO159H, PRO262E, PRO262H, PRO263E, PRO263H, PRO266E, PRO266H, PRO293E, PRO293H, PRO295E, PRO295H, PRO6E, PRO6H, SER155E, SER155H, SER160E, SER160H, SER17H, SER218E, SER218H, SER4E, SER4H, SER9H, THR158E, THR158H, THR206H, THR255E, THR255H, THR260E, THR260H, TRP296E, TRP296H, TYR204E, TYR204H, TYR214E, TYR214H, TYR223E, TYR223H, TYR5E, TYR5H, VAL205E, VAL205H, VAL209E, VAL209H, VAL213E, VAL213H, VAL222E, VAL222H, VAL254E, VAL254H, VAL261E, VAL261H, VAL265E, VAL265H
• F-G: ALA10G, ALA161F, ALA161G, ALA168F, ALA168G, ALA211F, ALA211G, ALA212F, ALA212G, ALA216F, ALA216G, ALA256F, ALA256G, ALA264F, ALA264G, ALA7F, ALA7G, ARG157F, ARG157G, ARG201F, ARG201G, ARG258F, ARG258G, ARG259F, ARG259G, ARG294F, ARG294G, ASP198F, ASP219F, ASP219G, CYS202F, CYS202G, GLN203F, GLN203G, GLU156F, GLU156G, GLU207F, GLU207G, GLU225F, GLU225G, GLY226G, HIS197F, HIS220F, HIS220G, HIS221F, HIS221G, HIS3F, HIS3G, ILE154F, ILE154G, ILE164F, ILE164G, LEU165F, LEU165G, LEU210F, LEU210G, LEU217F, LEU217G, LEU224F, LEU224G, LEU257F, LEU257G, LEU292F, LEU292G, LEU8F, LEU8G, LYS13F, LYS13G, LYS153F, LYS153G, LYS200F, LYS200G, LYS208F, LYS208G, LYS215F, LYS215G, PRO159F, PRO159G, PRO262F, PRO262G, PRO263F, PRO263G, PRO266F, PRO266G, PRO293F, PRO293G, PRO295F, PRO295G, PRO6F, PRO6G, SER155F, SER155G, SER160F, SER160G, SER218F, SER218G, SER4F, SER4G, SER9G, THR158F, THR158G, THR206F, THR255F, THR255G, THR260F, THR260G, TRP296F, TRP296G, TYR204F, TYR204G, TYR214F, TYR214G, TYR223F, TYR223G, TYR5F, TYR5G, VAL205F, VAL205G, VAL209F, VAL209G, VAL213F, VAL213G, VAL222F, VAL222G, VAL254F, VAL254G, VAL261F, VAL261G, VAL265F, VAL265G
• F-H: ALA161F, ALA161H, ARG157F, ARG157H, ARG201F, ARG201H, GLU156F, GLU156H, GLY118F, GLY118H, ILE154F, ILE154H, ILE164F, ILE164H, LEU162F, LEU162H, LYS208F, LYS208H, PRO159F, PRO159H, SER155F, SER155H, SER160F, SER160H, THR119F, THR119H, THR158F, THR158H, TYR204F, TYR204H, VAL205F, VAL205H
• F-J: ALA239F, ASN283J, ASP194F, ASP196F, CYS240F, CYS240J, GLU247J, GLU278J, GLU279F, GLU279J, GLY195F, GLY237F, GLY274F, HIS238F, HIS238J, ILE242F, ILE242J, ILE249J, LYS243F, LYS243J, PHE282J, PRO193F, PRO236F, PRO241F, PRO241J, PRO246J, SER276J, THR245J, TYR244J
• G-H: ALA117G, ALA117H, ALA161G, ALA161H, ALA163G, ALA163H, ALA168H, ALA172G, ALA172H, ALA175G, ALA175H, ALA216G, ALA216H, ALA7G, ALA7H, ARG134G, ARG134H, ARG157G, ARG157H, ARG173G, ARG173H, ASN167G, ASN167H, ASN169G, ASN169H, ASN181G, ASN181H, ASP110G, ASP110H, ASP120G, ASP120H, ASP129G, ASP129H, ASP219G, ASP219H, GLN126G, GLN126H, GLN179G, GLN179H, GLN180G, GLN180H, GLU122G, GLU122H, GLU133G, GLU133H, GLU156G, GLU156H, GLU166G, GLU166H, GLY112G, GLY112H, GLY118G, GLY118H, GLY121G, GLY121H, GLY127G, GLY127H, GLY130G, GLY130H, HIS220G, HIS220H, HIS221G, HIS221H, HIS3G, HIS3H, ILE177G, ILE177H, LEU116G, LEU116H, LEU128G, LEU128H, LEU131G, LEU131H, LEU162G, LEU162H, LEU165G, LEU165H, LEU217G, LEU217H, LEU8G, LEU8H, LYS111G, LYS111H, LYS215G, LYS215H, PRO115G, PRO115H, PRO6G, PRO6H, SER132G, SER132H, SER155G, SER155H, SER160G, SER160H, SER176G, SER176H, SER218G, SER218H, SER4G, SER4H, THR119G, THR119H, THR123G, THR123H, THR124G, THR124H, THR125G, THR125H, THR158G, THR158H, TRP148G, TRP148H, TYR5G, TYR5H, VAL113G, VAL114G, VAL114H, VAL170G, VAL170H, VAL222G, VAL222H
• G-J: ARG315J, ASN312J, TYR5G
• H-J: ALA239H, ALA41J, ARG315J, ARG43J, ASN312J, ASN51J, ASP120H, ASP194H, ASP196H, CYS240H, GLN46J, GLU156H, GLU50J, GLY121H, GLY195H, GLY237H, GLY38J, GLY48J, HIS197H, HIS238H, ILE154H, ILE47J, LEU44J, LYS153H, LYS42J, PRO193H, PRO241H, SER155H, SER45J, VAL49J
• I-J: ALA117I, ALA117J, ALA161I, ALA161J, ALA163I, ALA163J, ALA172I, ALA172J, ALA175J, ALA216I, ALA216J, ALA7I, ALA7J, ARG134I, ARG134J, ARG157I, ARG157J, ARG173I, ARG173J, ASN167I, ASN167J, ASN169I, ASN169J, ASN181I, ASP110J, ASP120I, ASP120J, ASP129I, ASP129J, ASP219I, ASP219J, GLN126I, GLN126J, GLN179I, GLN179J, GLN180I, GLN180J, GLU122I, GLU122J, GLU133I, GLU133J, GLU156I, GLU156J, GLU166I, GLU166J, GLY112J, GLY118I, GLY118J, GLY121I, GLY121J, GLY127I, GLY127J, GLY130I, GLY130J, HIS220I, HIS220J, HIS221I, HIS221J, HIS3I, HIS3J, ILE177I, ILE177J, LEU116I, LEU116J, LEU128I, LEU128J, LEU131I, LEU131J, LEU162I, LEU162J, LEU165I, LEU165J, LEU217I, LEU217J, LEU8I, LEU8J, LYS111I, LYS111J, LYS153I, LYS153J, LYS215I, LYS215J, PRO115I, PRO115J, PRO6I, PRO6J, SER132I, SER132J, SER155I, SER155J, SER160I, SER160J, SER176I, SER176J, SER218I, SER218J, SER4I, SER4J, THR119I, THR119J, THR123I, THR123J, THR124I, THR124J, THR125I, THR125J, THR158I, THR158J, TRP148I, TRP148J, TYR5I, TYR5J, VAL113I, VAL114I, VAL114J, VAL170I, VAL170J, VAL222I, VAL222J
• I-K: ALA161I, ALA161K, ARG157I, ARG157K, ARG201I, ARG201K, GLU156I, GLU156K, GLY118I, GLY118K, ILE154I, ILE154K, ILE164I, ILE164K, LEU162I, LEU162K, LYS208I, LYS208K, PRO159I, PRO159K, SER155I, SER155K, SER160I, SER160K, THR119I, THR119K, THR158I, THR158K, TYR204I, TYR204K, VAL205I, VAL205K
• I-L: ALA10I, ALA161I, ALA168I, ALA168L, ALA211I, ALA211L, ALA212I, ALA212L, ALA216I, ALA216L, ALA256I, ALA256L, ALA264I, ALA264L, ALA7I, ALA7L, ARG157I, ARG157L, ARG201I, ARG201L, ARG258I, ARG258L, ARG259I, ARG259L, ARG294I, ARG294L, ASP198I, ASP198L, ASP219I, ASP219L, CYS202I, CYS202L, GLN203I, GLN203L, GLU156I, GLU156L, GLU207I, GLU207L, GLU225I, GLU225L, GLY226I, HIS220I, HIS220L, HIS221I, HIS221L, HIS3I, HIS3L, ILE154I, ILE154L, ILE164I, ILE164L, LEU165I, LEU165L, LEU210I, LEU210L, LEU217I, LEU217L, LEU224I, LEU224L, LEU257I, LEU257L, LEU292I, LEU292L, LEU8I, LEU8L, LYS13I, LYS13L, LYS153I, LYS153L, LYS200I, LYS200L, LYS208I, LYS208L, LYS215I, LYS215L, PRO159I, PRO159L, PRO262I, PRO262L, PRO263I, PRO263L, PRO266I, PRO266L, PRO293I, PRO293L, PRO295I, PRO295L, PRO6I, PRO6L, SER155I, SER155L, SER160I, SER160L, SER218I, SER218L, SER4I, SER4L, THR158I, THR158L, THR206L, THR255I, THR255L, THR260I, THR260L, TRP296I, TRP296L, TYR204I, TYR204L, TYR214I, TYR214L, TYR223I, TYR223L, TYR5I, TYR5L, VAL205I, VAL205L, VAL209I, VAL209L, VAL213I, VAL213L, VAL222I, VAL222L, VAL254I, VAL254L, VAL261I, VAL261L, VAL265I, VAL265L
• J-K: ALA10J, ALA161J, ALA161K, ALA168J, ALA168K, ALA211J, ALA211K, ALA212J, ALA212K, ALA216J, ALA216K, ALA256J, ALA256K, ALA264J, ALA264K, ALA7J, ALA7K, ARG157J, ARG157K, ARG201J, ARG201K, ARG258J, ARG258K, ARG259J, ARG259K, ARG294J, ARG294K, ASP198K, ASP219J, ASP219K, CYS202J, CYS202K, GLN203J, GLN203K, GLU156J, GLU156K, GLU207J, GLU207K, GLU225J, GLU225K, GLY226J, HIS220J, HIS220K, HIS221J, HIS221K, HIS3J, HIS3K, ILE154J, ILE154K, ILE164J, ILE164K, LEU165J, LEU165K, LEU210J, LEU210K, LEU217J, LEU217K, LEU21J, LEU224J, LEU224K, LEU257J, LEU257K, LEU292J, LEU292K, LEU8J, LEU8K, LYS13J, LYS13K, LYS14J, LYS153J, LYS153K, LYS200J, LYS200K, LYS208J, LYS208K, LYS215J, LYS215K, PRO159J, PRO159K, PRO262J, PRO262K, PRO263J, PRO263K, PRO266J, PRO266K, PRO293J, PRO293K, PRO295J, PRO295K, PRO6J, PRO6K, SER155J, SER155K, SER160J, SER160K, SER218J, SER218K, SER4J, SER4K, SER9J, THR158J, THR158K, THR255J, THR255K, THR260J, THR260K, TRP296J, TRP296K, TYR204J, TYR204K, TYR214J, TYR214K, TYR223J, TYR223K, TYR5J, TYR5K, VAL205J, VAL205K, VAL209J, VAL209K, VAL213J, VAL213K, VAL222J, VAL222K, VAL254J, VAL254K, VAL261J, VAL261K, VAL265J, VAL265K
• J-L: ALA161J, ALA161L, ARG157J, ARG157L, ARG201J, ARG201L, GLU156J, GLU156L, GLY118J, GLY118L, ILE154J, ILE154L, ILE164J, ILE164L, LEU162J, LEU162L, LYS208J, LYS208L, PRO159J, PRO159L, SER155J, SER155L, SER160J, SER160L, THR119J, THR119L, THR158J, THR158L, TYR204J, TYR204L, VAL205J, VAL205L
• K-L: ALA117K, ALA117L, ALA161K, ALA161L, ALA163K, ALA163L, ALA168K, ALA168L, ALA172K, ALA172L, ALA175K, ALA175L, ALA216K, ALA216L, ALA7K, ALA7L, ARG134K, ARG134L, ARG157K, ARG157L, ARG173K, ARG173L, ASN167K, ASN167L, ASN169K, ASN169L, ASP110K, ASP110L, ASP120K, ASP120L, ASP129K, ASP129L, ASP219K, ASP219L, GLN126K, GLN126L, GLN179K, GLN179L, GLN180K, GLN180L, GLU122K, GLU122L, GLU133K, GLU133L, GLU156K, GLU156L, GLU166K, GLU166L, GLY112K, GLY112L, GLY118K, GLY118L, GLY121K, GLY121L, GLY127K, GLY127L, GLY130K, GLY130L, HIS220K, HIS220L, HIS221K, HIS221L, HIS3K, HIS3L, ILE177K, ILE177L, LEU116K, LEU116L, LEU128K, LEU128L, LEU131K, LEU131L, LEU162K, LEU162L, LEU165K, LEU165L, LEU217K, LEU217L, LEU8K, LEU8L, LYS111K, LYS111L, LYS153K, LYS215K, LYS215L, PRO115K, PRO115L, PRO6K, PRO6L, SER132K, SER132L, SER155K, SER155L, SER160K, SER160L, SER176K, SER176L, SER218K, SER218L, SER4K, SER4L, THR119K, THR119L, THR123K, THR123L, THR124K, THR124L, THR125K, THR125L, THR158K, THR158L, TRP148K, TRP148L, TYR5K, TYR5L, VAL109K, VAL109L, VAL113K, VAL113L, VAL114K, VAL114L, VAL170K, VAL170L, VAL222K, VAL222L