1X2R

structural basis for the defects of human lung cancer somatic mutations in the repression activity of keap1 on nrf2

• Total interactions analyzed: 1
• Total true interactions: 1
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 60
  • Norm. En. per Res.: -4.7002
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-26.2208	-88.9198	-166.87	-282.0106	60	16	0	5626	4	31	14

Interface residues

• A-B: ALA510A, ALA556A, ARG336A, ARG362A, ARG380A, ARG415A, ARG483A, ARG507A, ARG554A, ARG601A, ASN381A, ASN382A, ASN387A, ASN414A, ASP526A, ASP529A, ASP573A, ASP77B, GLN337A, GLN528A, GLN530A, GLU78B, GLU79B, GLU82B, GLY333A, GLY364A, GLY386A, GLY462A, GLY477A, GLY509A, GLY524A, GLY527A, GLY571A, GLY574A, GLY603A, GLY81B, HIS575A, ILE461A, LEU339A, LEU484A, LEU531A, LEU557A, LEU76B, LEU84B, PHE335A, PHE478A, PHE577A, PHE83B, PRO384A, SER338A, SER363A, SER383A, SER508A, SER555A, SER602A, THR576A, THR80B, TYR334A, TYR525A, TYR572A