1WPL

crystal structure of the inhibitory form of rat gtp cyclohydrolase i/gfrp complex

• Total interactions analyzed: 190
• Total true interactions: 85
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 113
  • Norm. En. per Res.: -4.3634
• Hub Node: A(10)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-114.9349	-40.1692	-334.543	-489.6472	113	22	4	13714	6	54	52
A-C	0.0	0.0	-1.0023	-1.0023	6	0	0	73	0	3	4
A-D	0.0	0.0	-0.9538	-0.9538	6	0	0	74	0	3	4
A-E	-111.4871	-46.6792	-320.19	-478.3563	113	24	4	13634	6	54	52
A-F	0.0	0.0	-0.4079	-0.4079	18	0	0	185	0	6	7
A-I	0.0	0.0	-15.1077	-15.1077	12	0	0	753	0	0	3
A-J	-53.3489	-44.8159	-544.484	-642.6488	162	35	13	23916	6	42	34
A-K	0.0	-14.8196	-34.2175	-49.0371	28	1	1	1581	0	7	4
A-L	0.0	0.0	-43.8986	-43.8986	40	4	2	2302	0	2	2
A-O	0.0	0.0	-0.3957	-0.3957	3	0	0	65	0	0	1
B-C	-112.909	-33.8299	-322.005	-468.7439	113	26	3	13665	6	52	52
B-D	0.0	0.0	-0.9471	-0.9471	6	0	0	74	0	3	4
B-E	0.0	0.0	-0.8542	-0.8542	6	0	0	69	0	3	4
B-H	0.0	0.0	-13.8711	-13.8711	12	0	0	735	0	0	1
B-I	-81.4455	-46.2022	-546.114	-673.7616	166	30	13	23867	6	41	34
B-J	0.0	0.0	-0.5933	-0.5933	21	0	0	233	0	8	8
B-K	0.0	0.0	-0.3899	-0.3899	3	0	0	63	0	0	1
B-L	0.0	-16.2319	-35.7581	-51.99	28	1	1	1587	0	8	4
B-M	0.0	0.0	-44.3985	-44.3985	41	2	2	2315	0	2	2
C-D	-114.2755	-34.862	-335.953	-485.0905	113	23	3	13843	6	54	52
C-E	0.0	0.0	-0.9468	-0.9468	6	0	0	70	0	3	4
C-G	0.0	0.0	-15.2445	-15.2445	12	0	0	754	0	0	2
C-H	-76.2116	-42.5573	-543.787	-662.5558	164	36	13	23912	6	43	34
C-I	0.0	0.0	-0.4106	-0.4106	21	0	0	180	0	8	7
C-L	0.0	0.0	-0.3733	-0.3733	3	0	0	62	0	0	1
C-M	0.0	-15.5417	-35.8046	-51.3463	28	1	1	1587	0	7	4
C-N	0.0	0.0	-44.2313	-44.2313	40	3	2	2308	0	2	2
D-E	-113.9285	-44.4495	-324.633	-483.011	113	22	4	13821	6	54	52
D-F	0.0	0.0	-17.0675	-17.0675	16	0	0	791	0	0	3
D-G	-56.7654	-43.017	-542.992	-642.7744	163	29	13	23862	6	42	34
D-H	0.0	0.0	-0.4121	-0.4121	19	0	0	180	0	7	7
D-M	0.0	0.0	-0.4244	-0.4244	3	0	0	68	0	0	1
D-N	0.0	-14.7701	-34.5702	-49.3403	29	2	1	1596	0	8	4
D-O	0.0	0.0	-43.0752	-43.0752	40	4	2	2306	0	2	2
E-F	-45.7364	-48.9278	-547.789	-642.4532	164	28	13	23969	6	43	34
E-G	0.0	0.0	-0.4582	-0.4582	19	0	0	188	0	7	7
E-J	0.0	0.0	-16.3021	-16.3021	14	0	0	784	0	0	3
E-K	0.0	0.0	-46.2482	-46.2482	41	4	2	2368	0	2	2
E-N	0.0	0.0	-0.4099	-0.4099	3	0	0	66	0	0	1
E-O	0.0	-15.4346	-34.7585	-50.1932	28	2	1	1578	0	7	4
F-G	-112.4568	-47.897	-314.984	-475.3378	112	25	4	13675	6	54	52
F-H	0.0	0.0	-1.0597	-1.0597	7	0	0	76	0	3	4
F-I	0.0	0.0	-0.9599	-0.9599	6	0	0	77	0	3	4
F-J	-115.5226	-41.5772	-324.344	-481.4438	112	25	4	13680	6	54	52
F-P	0.0	-14.8606	-33.9001	-48.7607	29	2	1	1585	0	8	4
F-Q	0.0	0.0	-47.9374	-47.9374	42	5	2	2445	0	2	2
F-T	0.0	0.0	-0.4403	-0.4403	3	0	0	68	0	0	1
G-H	-115.2531	-46.8144	-328.689	-490.7565	114	25	4	13839	6	54	52
G-I	0.0	0.0	-0.9403	-0.9403	7	0	0	73	0	3	4
G-J	0.0	0.0	-0.9904	-0.9904	6	0	0	76	0	3	4
G-P	0.0	0.0	-0.4109	-0.4109	3	0	0	65	0	0	1
G-Q	0.0	-15.046	-35.7826	-50.8287	29	1	1	1609	0	8	4
G-R	0.0	0.0	-49.1791	-49.1791	41	3	2	2419	0	2	2
H-I	-108.4338	-38.3693	-331.198	-478.0011	114	23	4	13903	6	54	52
H-J	0.0	0.0	-0.9732	-0.9732	6	0	0	75	0	3	4
H-Q	0.0	0.0	-0.4901	-0.4901	3	0	0	70	0	0	1
H-R	0.0	-15.0585	-35.4413	-50.4998	28	2	1	1607	0	7	4
H-S	0.0	0.0	-46.5789	-46.5789	39	4	2	2374	0	2	2
I-J	-117.9662	-43.4893	-331.613	-493.0685	113	22	4	13996	6	54	52
I-R	0.0	0.0	-0.3856	-0.3856	3	0	0	65	0	0	1
I-S	0.0	-13.8942	-33.3675	-47.2617	29	3	1	1588	0	7	4
I-T	0.0	0.0	-44.5119	-44.5119	40	4	2	2314	0	2	2
J-P	0.0	0.0	-47.2581	-47.2581	40	4	2	2403	0	2	2
J-S	0.0	0.0	-0.4728	-0.4728	3	0	0	70	0	0	1
J-T	0.0	-14.498	-33.9379	-48.4359	28	2	1	1584	0	8	4
K-L	-52.007	-48.3772	-276.387	-376.7712	89	18	5	10845	8	21	26
K-M	0.0	0.0	-0.2914	-0.2914	8	0	0	65	0	0	0
K-N	0.0	0.0	-0.2628	-0.2628	7	0	0	70	0	0	0
K-O	-20.7522	-46.9874	-268.602	-336.3416	91	20	5	10816	7	21	26
L-M	-46.5198	-46.0587	-266.459	-359.0375	92	12	5	10656	7	21	26
L-N	0.0	0.0	-0.2378	-0.2378	8	0	0	61	0	0	0
L-O	0.0	0.0	-0.3261	-0.3261	9	0	0	80	0	0	0
M-N	-49.7773	-49.5447	-281.258	-380.58	90	17	5	10994	8	21	26
M-O	0.0	0.0	-0.2995	-0.2995	8	0	0	75	0	0	0
N-O	-48.9754	-48.3697	-267.876	-365.2212	91	20	5	10752	7	21	26
P-Q	-52.7731	-45.2561	-268.467	-366.4963	91	13	5	10813	7	21	26
P-R	0.0	0.0	-0.328	-0.328	8	0	0	78	0	0	0
P-S	0.0	0.0	-0.316	-0.316	8	0	0	72	0	0	0
P-T	-22.4853	-47.1203	-278.202	-347.8076	91	14	5	10870	8	21	26
Q-R	-55.1603	-49.7766	-288.828	-393.7649	92	18	5	11139	8	21	26
Q-S	0.0	0.0	-0.3379	-0.3379	8	0	0	75	0	0	0
Q-T	0.0	0.0	-0.2885	-0.2885	7	0	0	65	0	0	0
R-S	-51.0044	-48.1321	-267.896	-367.0325	90	12	5	10743	8	21	26
R-T	0.0	0.0	-0.272	-0.272	8	0	0	64	0	0	0
S-T	-55.8518	-49.7218	-281.364	-386.9376	92	18	5	11051	8	21	26

Interface residues

• A-B: ALA160B, ALA181A, ALA199A, ARG142B, ARG161B, ARG168B, ARG175A, ARG207A, ARG226A, ARG232A, ARG232B, ARG240A, ARG240B, ASN213A, ASP114B, ASP116B, ASP118B, ASP125B, ASP127B, ASP228A, ASP228B, CYS132A, CYS203A, GLN173A, GLN179A, GLN210A, GLU115B, GLU119B, GLU164B, GLU174A, GLU198A, GLU227A, GLU233A, GLU233B, GLU234A, GLU234B, GLY141B, GLY146B, GLY155B, GLY208A, HIS117B, HIS134A, HIS135A, HIS144A, HIS144B, HIS201A, ILE112B, ILE122B, ILE126B, ILE145B, ILE162B, ILE165B, ILE197A, ILE239A, ILE239B, LEU148B, LEU154B, LEU156B, LEU159B, LEU176A, LEU222A, LEU236A, LEU236B, LEU238B, LYS124B, LYS158B, LYS178A, LYS211A, LYS215A, LYS230A, LYS230B, LYS98B, MET120B, MET128B, MET204A, MET212A, MET221A, PHE129B, PHE139A, PHE225A, PHE235A, PHE235B, PHE95B, PRO149B, PRO229A, PRO229B, SER157B, SER167B, SER214A, SER219A, SER241A, SER241B, THR177A, THR216A, THR218A, THR220A, THR231A, THR231B, THR237A, THR237B, TYR147B, VAL121B, VAL123B, VAL143B, VAL153B, VAL163B, VAL172A, VAL182A, VAL195A, VAL196A, VAL209A, VAL217A, VAL224A
• A-C: ARG240A, ARG240C, GLU233A, GLU233C, SER241C, THR237C
• A-D: ARG240A, ARG240D, GLU233A, GLU233D, SER241A, THR237A
• A-E: ALA160A, ALA181E, ALA199E, ARG142A, ARG161A, ARG168A, ARG175E, ARG207E, ARG226E, ARG232A, ARG232E, ARG240A, ARG240E, ASN213E, ASP114A, ASP116A, ASP118A, ASP125A, ASP127A, ASP228A, ASP228E, CYS132E, CYS203E, GLN173E, GLN179E, GLN210E, GLU115A, GLU119A, GLU164A, GLU174E, GLU198E, GLU227E, GLU233A, GLU233E, GLU234A, GLU234E, GLY141A, GLY146A, GLY155A, GLY208E, GLY223E, HIS117A, HIS134E, HIS135E, HIS144A, HIS144E, HIS201E, ILE112A, ILE122A, ILE126A, ILE145A, ILE162A, ILE165A, ILE197E, ILE239A, ILE239E, LEU148A, LEU154A, LEU156A, LEU159A, LEU176E, LEU222E, LEU236A, LEU236E, LEU238A, LYS124A, LYS158A, LYS178E, LYS211E, LYS215E, LYS230A, LYS230E, LYS98A, MET120A, MET128A, MET204E, MET212E, MET221E, PHE129A, PHE139E, PHE225E, PHE235A, PHE235E, PRO149A, PRO229A, PRO229E, SER157A, SER167A, SER214E, SER219E, SER241A, SER241E, THR177E, THR216E, THR218E, THR220E, THR231A, THR231E, THR237A, THR237E, TYR147A, VAL121A, VAL123A, VAL143A, VAL153A, VAL163A, VAL172E, VAL182E, VAL195E, VAL196E, VAL209E, VAL217E, VAL224E
• A-F: ARG142A, ARG142F, ARG88A, ARG88F, ASP110A, ASP110F, GLN80A, GLN80F, GLY81A, GLY81F, ILE112A, ILE112F, LYS158A, LYS158F, LYS84A, LYS84F, PHE113A, PHE113F
• A-I: ASN213A, ASN213I, GLN210A, GLN210I, LYS211A, LYS211I, MET212A, MET212I, VAL205A, VAL205I, VAL209A, VAL209I
• A-J: ALA63A, ALA63J, ALA64A, ALA64J, ALA65A, ALA65J, ALA89A, ALA89J, ALA90A, ALA90J, ALA92A, ALA92J, ARG142A, ARG142J, ARG168A, ARG168J, ARG169A, ARG169J, ARG175A, ARG175J, ARG207A, ARG207J, ARG50A, ARG50J, ARG71A, ARG71J, ARG79A, ARG79J, ARG88A, ARG88J, ASN213A, ASN213J, ASN55A, ASN55J, ASN58A, ASN58J, ASN61A, ASN61J, ASP127A, ASP127J, ASP54A, ASP54J, ASP76A, ASP76J, CYS132A, CYS132J, CYS203A, CYS203J, GLN171A, GLN171J, GLN210A, GLN210J, GLN80A, GLN80J, GLN94A, GLN94J, GLU133A, GLU133J, GLU164A, GLU164J, GLU75A, GLU75J, GLY141A, GLY141J, GLY208A, GLY208J, GLY74A, GLY74J, GLY81A, GLY81J, HIS134A, HIS134J, HIS135A, HIS135J, ILE69A, ILE69J, LEU136A, LEU136J, LEU170A, LEU170J, LEU57A, LEU57J, LEU59A, LEU59J, LEU62A, LEU62J, LEU70A, LEU70J, LEU73A, LEU73J, LEU82A, LEU82J, LEU83A, LEU83J, LYS211A, LYS211J, LYS84A, LYS84J, LYS98A, LYS98J, MET128A, MET128J, MET131A, MET131J, MET202A, MET202J, MET204A, MET204J, MET206A, MET206J, MET212A, MET212J, MET93A, MET93J, PHE129A, PHE129J, PHE139A, PHE139J, PHE95A, PHE95J, PHE96A, PHE96J, PRO138A, PRO138J, PRO60A, PRO60J, PRO77A, PRO77J, PRO86A, PRO86J, SER130A, SER130J, SER167A, SER167J, SER67A, SER67J, SER68A, SER68J, SER72A, SER72J, THR200A, THR200J, THR85A, THR85J, THR91A, THR91J, THR97A, THR97J, TRP87A, TRP87J, TYR100A, TYR100J, TYR66A, TYR66J, VAL137A, VAL137J, VAL140A, VAL140J, VAL172A, VAL172J, VAL205A, VAL205J
• A-K: ALA191A, ARG11K, ARG226A, ASN150A, ASN50K, ASP116A, ASP118A, ASP228A, GLN75K, GLN9K, GLU227A, GLY192A, GLY223A, GLY74K, HIS117A, ILE10K, LEU148A, LEU40K, LYS151A, LYS230A, PHE225A, PRO16K, PRO229A, THR231A, THR76K, VAL224A, VAL39K, VAL73K
• A-L: ALA181A, ALA183A, ALA191A, ARG226A, ARG232A, ARG38L, ASN150A, ASN42L, ASN43L, ASP228A, GLN152A, GLN179A, GLN189A, GLN75L, GLN9L, GLU186A, GLU227A, GLY192A, GLY223A, GLY41L, GLY74L, ILE10L, ILE184A, LEU188A, LEU222A, LEU40L, LYS178A, MET221A, PHE225A, PHE44L, PRO190A, PRO229A, THR185A, THR220A, THR76L, VAL182A, VAL193A, VAL224A, VAL39L, VAL73L
• A-O: GLN75O, LYS230A, PRO229A
• B-C: ALA160C, ALA181B, ALA199B, ARG142C, ARG161C, ARG168C, ARG175B, ARG207B, ARG226B, ARG232B, ARG232C, ARG240B, ARG240C, ASN213B, ASP114C, ASP116C, ASP118C, ASP125C, ASP127C, ASP228B, ASP228C, CYS132B, CYS203B, GLN173B, GLN179B, GLN210B, GLU115C, GLU119C, GLU164C, GLU174B, GLU198B, GLU227B, GLU233B, GLU233C, GLU234B, GLU234C, GLY141C, GLY146C, GLY155C, GLY208B, GLY223B, HIS117C, HIS134B, HIS135B, HIS144B, HIS144C, HIS201B, ILE112C, ILE122C, ILE126C, ILE145C, ILE162C, ILE165C, ILE197B, ILE239B, ILE239C, LEU148C, LEU154C, LEU156C, LEU159C, LEU176B, LEU222B, LEU236B, LEU236C, LEU238C, LYS124C, LYS158C, LYS178B, LYS211B, LYS215B, LYS230B, LYS230C, LYS98C, MET120C, MET128C, MET204B, MET212B, MET221B, PHE129C, PHE139B, PHE225B, PHE235B, PHE235C, PRO149C, PRO229B, PRO229C, SER157C, SER167C, SER214B, SER219B, SER241B, SER241C, THR177B, THR216B, THR218B, THR220B, THR231B, THR231C, THR237B, THR237C, TYR147C, VAL121C, VAL123C, VAL143C, VAL153C, VAL163C, VAL172B, VAL182B, VAL195B, VAL196B, VAL209B, VAL217B, VAL224B
• B-D: ARG240B, ARG240D, GLU233B, GLU233D, SER241D, THR237D
• B-E: ARG240B, ARG240E, GLU233B, GLU233E, SER241B, THR237B
• B-H: ASN213B, ASN213H, GLN210B, GLN210H, LYS211B, LYS211H, MET212B, MET212H, VAL205B, VAL205H, VAL209B, VAL209H
• B-I: ALA63B, ALA63I, ALA64B, ALA64I, ALA65B, ALA65I, ALA89B, ALA89I, ALA90B, ALA90I, ALA92B, ALA92I, ARG142B, ARG142I, ARG168B, ARG168I, ARG169B, ARG169I, ARG175B, ARG175I, ARG207B, ARG207I, ARG50B, ARG50I, ARG71B, ARG71I, ARG79B, ARG79I, ARG88B, ARG88I, ASN213B, ASN213I, ASN55B, ASN55I, ASN58B, ASN58I, ASN61B, ASN61I, ASP127B, ASP127I, ASP54B, ASP54I, ASP76B, ASP76I, CYS132B, CYS132I, CYS203B, CYS203I, GLN101B, GLN171B, GLN171I, GLN210B, GLN210I, GLN80B, GLN80I, GLN94B, GLN94I, GLU133B, GLU133I, GLU164B, GLU164I, GLU75B, GLU75I, GLY141B, GLY141I, GLY208B, GLY208I, GLY74B, GLY74I, GLY81B, GLY81I, HIS134B, HIS134I, HIS135B, HIS135I, HIS201I, ILE126I, ILE69B, ILE69I, LEU136B, LEU136I, LEU170B, LEU170I, LEU57B, LEU57I, LEU59B, LEU59I, LEU62B, LEU62I, LEU70B, LEU70I, LEU73B, LEU73I, LEU82B, LEU82I, LEU83B, LEU83I, LYS211B, LYS211I, LYS84B, LYS84I, LYS98B, LYS98I, MET128B, MET128I, MET131B, MET131I, MET202B, MET202I, MET204B, MET204I, MET206B, MET206I, MET212B, MET212I, MET93B, MET93I, PHE129B, PHE129I, PHE139B, PHE139I, PHE95B, PHE95I, PHE96B, PHE96I, PRO138B, PRO138I, PRO60B, PRO60I, PRO77B, PRO77I, PRO86B, PRO86I, SER130B, SER130I, SER167B, SER167I, SER51B, SER67B, SER67I, SER68B, SER68I, SER72B, SER72I, THR200B, THR200I, THR85B, THR85I, THR91B, THR91I, THR97B, THR97I, TRP87B, TRP87I, TYR100B, TYR100I, TYR66B, TYR66I, VAL137B, VAL137I, VAL140B, VAL140I, VAL172B, VAL172I, VAL205B, VAL205I
• B-J: ARG142B, ARG142J, ARG88B, ARG88J, ASP110B, ASP110J, ASP114J, GLN80B, GLN80J, GLY155B, GLY155J, GLY81B, GLY81J, ILE112B, ILE112J, LYS158B, LYS158J, LYS84B, LYS84J, PHE113B, PHE113J
• B-K: GLN75K, LYS230B, PRO229B
• B-L: ALA191B, ARG11L, ARG226B, ASN150B, ASN50L, ASP116B, ASP118B, ASP228B, GLN75L, GLN9L, GLU227B, GLY192B, GLY223B, GLY74L, HIS117B, ILE10L, LEU148B, LEU40L, LYS151B, LYS230B, PHE225B, PRO16L, PRO229B, THR231B, THR76L, VAL224B, VAL39L, VAL73L
• B-M: ALA181B, ALA183B, ALA191B, ARG226B, ARG232B, ARG38M, ASN150B, ASN42M, ASN43M, ASP228B, GLN152B, GLN179B, GLN189B, GLN75M, GLN9M, GLU186B, GLU227B, GLY192B, GLY223B, GLY41M, GLY74M, ILE10M, ILE184B, LEU188B, LEU222B, LEU40M, LYS178B, MET18M, MET221B, PHE225B, PHE44M, PRO190B, PRO229B, THR185B, THR220B, THR76M, VAL182B, VAL193B, VAL224B, VAL39M, VAL73M
• C-D: ALA160D, ALA181C, ALA199C, ARG142D, ARG161D, ARG168D, ARG175C, ARG207C, ARG226C, ARG232C, ARG232D, ARG240C, ARG240D, ASN213C, ASP114D, ASP116D, ASP118D, ASP125D, ASP127D, ASP228C, ASP228D, CYS132C, CYS203C, GLN173C, GLN179C, GLN210C, GLU115D, GLU119D, GLU164D, GLU174C, GLU198C, GLU227C, GLU233C, GLU233D, GLU234C, GLU234D, GLY141D, GLY146D, GLY155D, GLY208C, GLY223C, HIS117D, HIS134C, HIS135C, HIS144C, HIS144D, HIS201C, ILE112D, ILE122D, ILE126D, ILE145D, ILE162D, ILE165D, ILE197C, ILE239C, ILE239D, LEU148D, LEU154D, LEU156D, LEU159D, LEU176C, LEU222C, LEU236C, LEU236D, LEU238D, LYS124D, LYS158D, LYS178C, LYS211C, LYS215C, LYS230C, LYS230D, LYS98D, MET120D, MET128D, MET204C, MET212C, MET221C, PHE129D, PHE139C, PHE225C, PHE235C, PHE235D, PRO149D, PRO229C, PRO229D, SER157D, SER167D, SER214C, SER219C, SER241C, SER241D, THR177C, THR216C, THR218C, THR220C, THR231C, THR231D, THR237C, THR237D, TYR147D, VAL121D, VAL123D, VAL143D, VAL153D, VAL163D, VAL172C, VAL182C, VAL195C, VAL196C, VAL209C, VAL217C, VAL224C
• C-E: ARG240C, ARG240E, GLU233C, GLU233E, SER241E, THR237E
• C-G: ASN213C, ASN213G, GLN210C, GLN210G, LYS211C, LYS211G, MET212C, MET212G, VAL205C, VAL205G, VAL209C, VAL209G
• C-H: ALA63C, ALA63H, ALA64C, ALA64H, ALA65C, ALA65H, ALA89C, ALA89H, ALA90C, ALA90H, ALA92C, ALA92H, ARG142C, ARG142H, ARG168C, ARG168H, ARG169C, ARG169H, ARG175C, ARG175H, ARG207C, ARG207H, ARG50C, ARG50H, ARG71C, ARG71H, ARG79C, ARG79H, ARG88C, ARG88H, ASN213C, ASN213H, ASN55C, ASN55H, ASN58C, ASN58H, ASN61C, ASN61H, ASP127C, ASP127H, ASP54C, ASP54H, ASP76C, ASP76H, CYS132C, CYS132H, CYS203C, CYS203H, GLN171C, GLN171H, GLN210C, GLN210H, GLN80C, GLN80H, GLN94C, GLN94H, GLU133C, GLU133H, GLU164C, GLU164H, GLU75C, GLU75H, GLY141C, GLY141H, GLY208C, GLY208H, GLY74C, GLY74H, GLY81C, GLY81H, HIS134C, HIS134H, HIS135C, HIS135H, HIS201C, HIS201H, ILE69C, ILE69H, LEU136C, LEU136H, LEU170C, LEU170H, LEU57C, LEU57H, LEU59C, LEU59H, LEU62C, LEU62H, LEU70C, LEU70H, LEU73C, LEU73H, LEU82C, LEU82H, LEU83C, LEU83H, LYS211C, LYS211H, LYS84C, LYS84H, LYS98C, LYS98H, MET128C, MET128H, MET131C, MET131H, MET202C, MET202H, MET204C, MET204H, MET206C, MET206H, MET212C, MET212H, MET93C, MET93H, PHE129C, PHE129H, PHE139C, PHE139H, PHE95C, PHE95H, PHE96C, PHE96H, PRO138C, PRO138H, PRO60C, PRO60H, PRO77C, PRO77H, PRO86C, PRO86H, SER130C, SER130H, SER167C, SER167H, SER67C, SER67H, SER68C, SER68H, SER72C, SER72H, THR200C, THR200H, THR85C, THR85H, THR91C, THR91H, THR97C, THR97H, TRP87C, TRP87H, TYR100C, TYR100H, TYR66C, TYR66H, VAL137C, VAL137H, VAL140C, VAL140H, VAL172C, VAL172H, VAL205C, VAL205H
• C-I: ARG142C, ARG142I, ARG88C, ARG88I, ASP110C, ASP110I, ASP114I, GLN80C, GLN80I, GLY81C, GLY81I, ILE112C, ILE112I, LYS158C, LYS158I, LYS84C, LYS84I, PHE113C, PHE113I, SER157C, SER157I
• C-L: GLN75L, LYS230C, PRO229C
• C-M: ALA191C, ARG11M, ARG226C, ASN150C, ASN50M, ASP116C, ASP118C, ASP228C, GLN75M, GLN9M, GLU227C, GLY192C, GLY223C, GLY74M, HIS117C, ILE10M, LEU148C, LEU40M, LYS151C, LYS230C, PHE225C, PRO16M, PRO229C, THR231C, THR76M, VAL224C, VAL39M, VAL73M
• C-N: ALA181C, ALA183C, ALA191C, ARG226C, ARG232C, ARG38N, ASN150C, ASN42N, ASN43N, ASP228C, GLN152C, GLN179C, GLN189C, GLN75N, GLN9N, GLU186C, GLU227C, GLY192C, GLY223C, GLY41N, GLY74N, ILE10N, ILE184C, LEU188C, LEU222C, LEU40N, LYS178C, MET221C, PHE225C, PHE44N, PRO190C, PRO229C, THR185C, THR220C, THR76N, VAL182C, VAL193C, VAL224C, VAL39N, VAL73N
• D-E: ALA160E, ALA181D, ALA199D, ARG142E, ARG161E, ARG168E, ARG175D, ARG207D, ARG226D, ARG232D, ARG232E, ARG240D, ARG240E, ASN213D, ASP114E, ASP116E, ASP118E, ASP125E, ASP127E, ASP228D, ASP228E, CYS132D, CYS203D, GLN173D, GLN179D, GLN210D, GLU115E, GLU119E, GLU164E, GLU174D, GLU198D, GLU227D, GLU233D, GLU233E, GLU234D, GLU234E, GLY141E, GLY146E, GLY155E, GLY208D, GLY223D, HIS117E, HIS134D, HIS135D, HIS144D, HIS144E, HIS201D, ILE112E, ILE122E, ILE126E, ILE145E, ILE162E, ILE165E, ILE197D, ILE239D, ILE239E, LEU148E, LEU154E, LEU156E, LEU159E, LEU176D, LEU222D, LEU236D, LEU236E, LEU238E, LYS124E, LYS158E, LYS178D, LYS211D, LYS215D, LYS230D, LYS230E, LYS98E, MET120E, MET128E, MET204D, MET212D, MET221D, PHE129E, PHE139D, PHE225D, PHE235D, PHE235E, PRO149E, PRO229D, PRO229E, SER157E, SER167E, SER214D, SER219D, SER241D, SER241E, THR177D, THR216D, THR218D, THR220D, THR231D, THR231E, THR237D, THR237E, TYR147E, VAL121E, VAL123E, VAL143E, VAL153E, VAL163E, VAL172D, VAL182D, VAL195D, VAL196D, VAL209D, VAL217D, VAL224D
• D-F: ASN213D, ASN213F, GLN210D, GLN210F, LYS211D, LYS211F, MET206D, MET206F, MET212D, MET212F, SER214D, SER214F, VAL205D, VAL205F, VAL209D, VAL209F
• D-G: ALA63D, ALA63G, ALA64D, ALA64G, ALA65D, ALA65G, ALA89D, ALA89G, ALA90D, ALA90G, ALA92D, ALA92G, ARG142D, ARG142G, ARG168D, ARG168G, ARG169D, ARG169G, ARG175D, ARG175G, ARG207D, ARG207G, ARG50D, ARG50G, ARG71D, ARG71G, ARG79D, ARG79G, ARG88D, ARG88G, ASN213D, ASN213G, ASN55D, ASN55G, ASN58D, ASN58G, ASN61D, ASN61G, ASP127D, ASP127G, ASP54D, ASP54G, ASP76D, ASP76G, CYS132D, CYS132G, CYS203D, CYS203G, GLN171D, GLN171G, GLN210D, GLN210G, GLN80D, GLN80G, GLN94D, GLN94G, GLU133D, GLU133G, GLU164D, GLU164G, GLU75D, GLU75G, GLY141D, GLY141G, GLY208D, GLY208G, GLY74D, GLY74G, GLY81D, GLY81G, HIS134D, HIS134G, HIS135D, HIS135G, HIS201D, ILE69D, ILE69G, LEU136D, LEU136G, LEU170D, LEU170G, LEU57D, LEU57G, LEU59D, LEU59G, LEU62D, LEU62G, LEU70D, LEU70G, LEU73D, LEU73G, LEU82D, LEU82G, LEU83D, LEU83G, LYS211D, LYS211G, LYS84D, LYS84G, LYS98D, LYS98G, MET128D, MET128G, MET131D, MET131G, MET202D, MET202G, MET204D, MET204G, MET206D, MET206G, MET212D, MET212G, MET93D, MET93G, PHE129D, PHE129G, PHE139D, PHE139G, PHE95D, PHE95G, PHE96D, PHE96G, PRO138D, PRO138G, PRO60D, PRO60G, PRO77D, PRO77G, PRO86D, PRO86G, SER130D, SER130G, SER167D, SER167G, SER67D, SER67G, SER68D, SER68G, SER72D, SER72G, THR200D, THR200G, THR85D, THR85G, THR91D, THR91G, THR97D, THR97G, TRP87D, TRP87G, TYR100D, TYR100G, TYR66D, TYR66G, VAL137D, VAL137G, VAL140D, VAL140G, VAL172D, VAL172G, VAL205D, VAL205G
• D-H: ARG142D, ARG142H, ARG88D, ARG88H, ASP110D, ASP110H, GLN80D, GLN80H, GLY81D, GLY81H, ILE112D, ILE112H, LYS158D, LYS158H, LYS84D, LYS84H, PHE113D, PHE113H, SER157H
• D-M: GLN75M, LYS230D, PRO229D
• D-N: ALA191D, ARG11N, ARG226D, ARG37N, ASN150D, ASN50N, ASP116D, ASP118D, ASP228D, GLN75N, GLN9N, GLU227D, GLY192D, GLY223D, GLY74N, HIS117D, ILE10N, LEU148D, LEU40N, LYS151D, LYS230D, PHE225D, PRO16N, PRO229D, THR231D, THR76N, VAL224D, VAL39N, VAL73N
• D-O: ALA181D, ALA183D, ALA191D, ARG226D, ARG232D, ARG38O, ASN150D, ASN42O, ASN43O, ASP228D, GLN152D, GLN179D, GLN189D, GLN75O, GLN9O, GLU186D, GLU227D, GLY192D, GLY223D, GLY41O, GLY74O, ILE10O, ILE184D, LEU188D, LEU222D, LEU40O, LYS178D, MET221D, PHE225D, PHE44O, PRO190D, PRO229D, THR185D, THR220D, THR76O, VAL182D, VAL193D, VAL224D, VAL39O, VAL73O
• E-F: ALA63E, ALA63F, ALA64E, ALA64F, ALA65E, ALA65F, ALA89E, ALA89F, ALA90E, ALA90F, ALA92E, ALA92F, ARG142E, ARG142F, ARG168E, ARG168F, ARG169E, ARG169F, ARG175E, ARG175F, ARG207E, ARG207F, ARG50E, ARG50F, ARG71E, ARG71F, ARG79E, ARG79F, ARG88E, ARG88F, ASN213E, ASN213F, ASN55E, ASN55F, ASN58E, ASN58F, ASN61E, ASN61F, ASP127E, ASP127F, ASP54E, ASP54F, ASP76E, ASP76F, CYS132E, CYS132F, CYS203E, CYS203F, GLN171E, GLN171F, GLN210E, GLN210F, GLN80E, GLN80F, GLN94E, GLN94F, GLU133E, GLU133F, GLU164E, GLU164F, GLU75E, GLU75F, GLY141E, GLY141F, GLY208E, GLY208F, GLY74E, GLY74F, GLY81E, GLY81F, HIS134E, HIS134F, HIS135E, HIS135F, HIS201E, HIS201F, ILE69E, ILE69F, LEU136E, LEU136F, LEU170E, LEU170F, LEU57E, LEU57F, LEU59E, LEU59F, LEU62E, LEU62F, LEU70E, LEU70F, LEU73E, LEU73F, LEU82E, LEU82F, LEU83E, LEU83F, LYS211E, LYS211F, LYS84E, LYS84F, LYS98E, LYS98F, MET128E, MET128F, MET131E, MET131F, MET202E, MET202F, MET204E, MET204F, MET206E, MET206F, MET212E, MET212F, MET93E, MET93F, PHE129E, PHE129F, PHE139E, PHE139F, PHE95E, PHE95F, PHE96E, PHE96F, PRO138E, PRO138F, PRO60E, PRO60F, PRO77E, PRO77F, PRO86E, PRO86F, SER130E, SER130F, SER167E, SER167F, SER67E, SER67F, SER68E, SER68F, SER72E, SER72F, THR200E, THR200F, THR85E, THR85F, THR91E, THR91F, THR97E, THR97F, TRP87E, TRP87F, TYR100E, TYR100F, TYR66E, TYR66F, VAL137E, VAL137F, VAL140E, VAL140F, VAL172E, VAL172F, VAL205E, VAL205F
• E-G: ARG142E, ARG142G, ARG88E, ARG88G, ASP110E, ASP110G, GLN80E, GLN80G, GLY155E, GLY81E, GLY81G, ILE112E, ILE112G, LYS158E, LYS158G, LYS84E, LYS84G, PHE113E, PHE113G
• E-J: ASN213E, ASN213J, GLN210E, GLN210J, LYS211E, LYS211J, MET206E, MET206J, MET212E, MET212J, VAL205E, VAL205J, VAL209E, VAL209J
• E-K: ALA181E, ALA183E, ALA191E, ARG226E, ARG232E, ARG38K, ASN150E, ASN42K, ASN43K, ASP228E, GLN152E, GLN179E, GLN189E, GLN75K, GLN9K, GLU186E, GLU227E, GLY192E, GLY223E, GLY41K, GLY74K, ILE10K, ILE184E, LEU188E, LEU222E, LEU40K, LYS151E, LYS178E, MET221E, PHE225E, PHE44K, PRO190E, PRO229E, THR185E, THR220E, THR76K, VAL182E, VAL193E, VAL224E, VAL39K, VAL73K
• E-N: GLN75N, LYS230E, PRO229E
• E-O: ALA191E, ARG11O, ARG226E, ASN150E, ASN50O, ASP116E, ASP118E, ASP228E, GLN75O, GLN9O, GLU227E, GLY192E, GLY223E, GLY74O, HIS117E, ILE10O, LEU148E, LEU40O, LYS151E, LYS230E, PHE225E, PRO16O, PRO229E, THR231E, THR76O, VAL224E, VAL39O, VAL73O
• F-G: ALA160G, ALA181F, ALA199F, ARG142G, ARG161G, ARG168G, ARG175F, ARG207F, ARG226F, ARG232F, ARG232G, ARG240F, ARG240G, ASN213F, ASP114G, ASP116G, ASP118G, ASP125G, ASP127G, ASP228F, ASP228G, CYS132F, CYS203F, GLN173F, GLN179F, GLN210F, GLU115G, GLU119G, GLU164G, GLU174F, GLU198F, GLU227F, GLU233F, GLU233G, GLU234F, GLU234G, GLY141G, GLY146G, GLY155G, GLY208F, GLY223F, HIS117G, HIS134F, HIS135F, HIS144F, HIS144G, HIS201F, ILE112G, ILE122G, ILE126G, ILE145G, ILE162G, ILE197F, ILE239F, ILE239G, LEU148G, LEU154G, LEU156G, LEU159G, LEU176F, LEU222F, LEU236F, LEU236G, LEU238G, LYS124G, LYS158G, LYS178F, LYS211F, LYS215F, LYS230F, LYS230G, LYS98G, MET120G, MET128G, MET204F, MET212F, MET221F, PHE129G, PHE139F, PHE225F, PHE235F, PHE235G, PRO149G, PRO229F, PRO229G, SER157G, SER167G, SER214F, SER219F, SER241F, SER241G, THR177F, THR216F, THR218F, THR220F, THR231F, THR231G, THR237F, THR237G, TYR147G, VAL121G, VAL123G, VAL143G, VAL153G, VAL163G, VAL172F, VAL182F, VAL195F, VAL196F, VAL209F, VAL217F, VAL224F
• F-H: ARG240F, ARG240H, GLU233F, GLU233H, SER241F, SER241H, THR237H
• F-I: ARG240F, ARG240I, GLU233F, GLU233I, SER241F, THR237F
• F-J: ALA160F, ALA181J, ALA199J, ARG142F, ARG161F, ARG168F, ARG175J, ARG207J, ARG226J, ARG232F, ARG232J, ARG240F, ARG240J, ASN213J, ASP114F, ASP116F, ASP118F, ASP125F, ASP127F, ASP228F, ASP228J, CYS132J, CYS203J, GLN173J, GLN179J, GLN210J, GLU115F, GLU119F, GLU164F, GLU174J, GLU198J, GLU227J, GLU233F, GLU233J, GLU234F, GLU234J, GLY141F, GLY146F, GLY155F, GLY208J, GLY223J, HIS117F, HIS134J, HIS135J, HIS144F, HIS144J, HIS201J, ILE112F, ILE122F, ILE126F, ILE145F, ILE162F, ILE197J, ILE239F, ILE239J, LEU148F, LEU154F, LEU156F, LEU159F, LEU176J, LEU222J, LEU236F, LEU236J, LEU238F, LYS124F, LYS158F, LYS178J, LYS211J, LYS215J, LYS230F, LYS230J, LYS98F, MET120F, MET128F, MET204J, MET212J, MET221J, PHE129F, PHE139J, PHE225J, PHE235F, PHE235J, PRO149F, PRO229F, PRO229J, SER157F, SER167F, SER214J, SER219J, SER241F, SER241J, THR177J, THR216J, THR218J, THR220J, THR231F, THR231J, THR237F, THR237J, TYR147F, VAL121F, VAL123F, VAL143F, VAL153F, VAL163F, VAL172J, VAL182J, VAL195J, VAL196J, VAL209J, VAL217J, VAL224J
• F-P: ALA191F, ARG11P, ARG226F, ARG37P, ASN150F, ASN50P, ASP116F, ASP118F, ASP228F, GLN75P, GLN9P, GLU227F, GLY192F, GLY223F, GLY74P, HIS117F, ILE10P, LEU148F, LEU40P, LYS151F, LYS230F, PHE225F, PRO16P, PRO229F, THR231F, THR76P, VAL224F, VAL39P, VAL73P
• F-Q: ALA181F, ALA183F, ALA191F, ARG226F, ARG232F, ARG38Q, ASN150F, ASN42Q, ASN43Q, ASP228F, GLN152F, GLN179F, GLN189F, GLN75Q, GLN9Q, GLU186F, GLU227F, GLY192F, GLY223F, GLY41Q, GLY74Q, ILE10Q, ILE184F, LEU188F, LEU222F, LEU40Q, LYS151F, LYS178F, MET18Q, MET221F, PHE225F, PHE44Q, PRO190F, PRO229F, THR185F, THR220F, THR76Q, VAL182F, VAL193F, VAL224F, VAL39Q, VAL73Q
• F-T: GLN75T, LYS230F, PRO229F
• G-H: ALA160H, ALA181G, ALA199G, ARG142H, ARG161H, ARG168H, ARG175G, ARG207G, ARG226G, ARG232G, ARG232H, ARG240G, ARG240H, ASN213G, ASP114H, ASP116H, ASP118H, ASP125H, ASP127H, ASP228G, ASP228H, CYS132G, CYS203G, GLN173G, GLN179G, GLN210G, GLU115H, GLU119H, GLU164H, GLU174G, GLU198G, GLU227G, GLU233G, GLU233H, GLU234G, GLU234H, GLY141H, GLY146H, GLY155H, GLY208G, GLY223G, HIS117H, HIS134G, HIS135G, HIS144G, HIS144H, HIS201G, ILE112H, ILE122H, ILE126H, ILE145H, ILE162H, ILE165H, ILE197G, ILE239G, ILE239H, LEU148H, LEU154H, LEU156H, LEU159H, LEU176G, LEU222G, LEU236G, LEU236H, LEU238H, LYS124H, LYS158H, LYS178G, LYS211G, LYS215G, LYS230G, LYS230H, LYS98H, MET120H, MET128H, MET204G, MET212G, MET221G, PHE129H, PHE139G, PHE225G, PHE235G, PHE235H, PRO149H, PRO229G, PRO229H, SER157H, SER167H, SER214G, SER219G, SER241G, SER241H, THR177G, THR200G, THR216G, THR218G, THR220G, THR231G, THR231H, THR237G, THR237H, TYR147H, VAL121H, VAL123H, VAL143H, VAL153H, VAL163H, VAL172G, VAL182G, VAL195G, VAL196G, VAL209G, VAL217G, VAL224G
• G-I: ARG240G, ARG240I, GLU233G, GLU233I, SER241G, SER241I, THR237I
• G-J: ARG240G, ARG240J, GLU233G, GLU233J, SER241G, THR237G
• G-P: GLN75P, LYS230G, PRO229G
• G-Q: ALA191G, ARG11Q, ARG226G, ARG37Q, ASN150G, ASN50Q, ASP116G, ASP118G, ASP228G, GLN75Q, GLN9Q, GLU227G, GLY192G, GLY223G, GLY74Q, HIS117G, ILE10Q, LEU148G, LEU40Q, LYS151G, LYS230G, PHE225G, PRO16Q, PRO229G, THR231G, THR76Q, VAL224G, VAL39Q, VAL73Q
• G-R: ALA181G, ALA183G, ALA191G, ARG226G, ARG232G, ARG38R, ASN150G, ASN42R, ASN43R, ASP228G, GLN152G, GLN179G, GLN189G, GLN75R, GLN9R, GLU186G, GLU227G, GLY192G, GLY223G, GLY41R, GLY74R, ILE10R, ILE184G, LEU188G, LEU222G, LEU40R, LYS151G, LYS178G, MET221G, PHE225G, PHE44R, PRO190G, PRO229G, THR185G, THR220G, THR76R, VAL182G, VAL193G, VAL224G, VAL39R, VAL73R
• H-I: ALA160I, ALA181H, ALA199H, ARG142I, ARG161I, ARG168I, ARG175H, ARG207H, ARG226H, ARG232H, ARG232I, ARG240H, ARG240I, ASN213H, ASP114I, ASP116I, ASP118I, ASP125I, ASP127I, ASP228H, ASP228I, CYS132H, CYS203H, GLN173H, GLN179H, GLN210H, GLU115I, GLU119I, GLU164I, GLU174H, GLU198H, GLU227H, GLU233H, GLU233I, GLU234H, GLU234I, GLY141I, GLY146I, GLY155I, GLY208H, GLY223H, HIS117I, HIS134H, HIS135H, HIS144H, HIS144I, HIS201H, ILE112I, ILE122I, ILE126I, ILE145I, ILE162I, ILE165I, ILE197H, ILE239H, ILE239I, LEU148I, LEU154I, LEU156I, LEU159I, LEU176H, LEU222H, LEU236H, LEU236I, LEU238I, LYS124I, LYS158I, LYS178H, LYS211H, LYS215H, LYS230H, LYS230I, LYS98I, MET120I, MET128I, MET204H, MET212H, MET221H, PHE129I, PHE139H, PHE225H, PHE235H, PHE235I, PRO149I, PRO229H, PRO229I, SER157I, SER167I, SER214H, SER219H, SER241H, SER241I, THR177H, THR200H, THR216H, THR218H, THR220H, THR231H, THR231I, THR237H, THR237I, TYR147I, VAL121I, VAL123I, VAL143I, VAL153I, VAL163I, VAL172H, VAL182H, VAL195H, VAL196H, VAL209H, VAL217H, VAL224H
• H-J: ARG240H, ARG240J, GLU233H, GLU233J, SER241J, THR237J
• H-Q: GLN75Q, LYS230H, PRO229H
• H-R: ALA191H, ARG11R, ARG226H, ASN150H, ASN50R, ASP116H, ASP118H, ASP228H, GLN75R, GLN9R, GLU227H, GLY192H, GLY223H, GLY74R, HIS117H, ILE10R, LEU148H, LEU40R, LYS151H, LYS230H, PHE225H, PRO16R, PRO229H, THR231H, THR76R, VAL224H, VAL39R, VAL73R
• H-S: ALA181H, ALA183H, ALA191H, ARG226H, ARG38S, ASN150H, ASN42S, ASN43S, ASP228H, GLN152H, GLN179H, GLN189H, GLN75S, GLN9S, GLU186H, GLU227H, GLY192H, GLY223H, GLY41S, GLY74S, ILE10S, ILE184H, LEU188H, LEU222H, LEU40S, LYS178H, MET221H, PHE225H, PHE44S, PRO190H, PRO229H, THR185H, THR220H, THR76S, VAL182H, VAL193H, VAL224H, VAL39S, VAL73S
• I-J: ALA160J, ALA181I, ALA199I, ARG142J, ARG161J, ARG168J, ARG175I, ARG207I, ARG226I, ARG232I, ARG232J, ARG240I, ARG240J, ASN213I, ASP114J, ASP116J, ASP118J, ASP125J, ASP127J, ASP228I, ASP228J, CYS132I, CYS203I, GLN173I, GLN179I, GLN210I, GLU115J, GLU119J, GLU164J, GLU174I, GLU198I, GLU227I, GLU233I, GLU233J, GLU234I, GLU234J, GLY141J, GLY146J, GLY155J, GLY208I, GLY223I, HIS117J, HIS134I, HIS135I, HIS144I, HIS144J, HIS201I, ILE112J, ILE122J, ILE126J, ILE145J, ILE162J, ILE165J, ILE197I, ILE239I, ILE239J, LEU148J, LEU154J, LEU156J, LEU159J, LEU176I, LEU222I, LEU236I, LEU236J, LEU238J, LYS124J, LYS158J, LYS178I, LYS211I, LYS215I, LYS230I, LYS230J, LYS98J, MET120J, MET128J, MET204I, MET212I, MET221I, PHE129J, PHE139I, PHE225I, PHE235I, PHE235J, PRO149J, PRO229I, PRO229J, SER157J, SER167J, SER214I, SER219I, SER241I, SER241J, THR177I, THR216I, THR218I, THR220I, THR231I, THR231J, THR237I, THR237J, TYR147J, VAL121J, VAL123J, VAL143J, VAL153J, VAL163J, VAL172I, VAL182I, VAL195I, VAL196I, VAL209I, VAL217I, VAL224I
• I-R: GLN75R, LYS230I, PRO229I
• I-S: ALA191I, ARG11S, ARG226I, ARG37S, ASN150I, ASN50S, ASP116I, ASP118I, ASP228I, GLN75S, GLN9S, GLU227I, GLY192I, GLY223I, GLY74S, HIS117I, ILE10S, LEU148I, LEU40S, LYS151I, LYS230I, PHE225I, PRO16S, PRO229I, THR231I, THR76S, VAL224I, VAL39S, VAL73S
• I-T: ALA181I, ALA183I, ALA191I, ARG226I, ARG232I, ARG38T, ASN150I, ASN42T, ASN43T, ASP228I, GLN152I, GLN179I, GLN189I, GLN75T, GLN9T, GLU186I, GLU227I, GLY192I, GLY223I, GLY41T, GLY74T, ILE10T, ILE184I, LEU188I, LEU222I, LEU40T, LYS178I, MET221I, PHE225I, PHE44T, PRO190I, PRO229I, THR185I, THR220I, THR76T, VAL182I, VAL193I, VAL224I, VAL39T, VAL73T
• J-P: ALA181J, ALA183J, ALA191J, ARG226J, ARG232J, ARG38P, ASN150J, ASN42P, ASN43P, ASP228J, GLN152J, GLN179J, GLN189J, GLN75P, GLN9P, GLU186J, GLU227J, GLY192J, GLY223J, GLY41P, GLY74P, ILE10P, ILE184J, LEU188J, LEU222J, LEU40P, LYS178J, MET221J, PHE225J, PHE44P, PRO190J, PRO229J, THR185J, THR220J, THR76P, VAL182J, VAL193J, VAL224J, VAL39P, VAL73P
• J-S: GLN75S, LYS230J, PRO229J
• J-T: ALA191J, ARG11T, ARG226J, ASN150J, ASN50T, ASP116J, ASP118J, ASP228J, GLN75T, GLN9T, GLU227J, GLY192J, GLY223J, GLY74T, HIS117J, ILE10T, LEU148J, LEU40T, LYS151J, LYS230J, PHE225J, PRO16T, PRO229J, THR231J, THR76T, VAL224J, VAL39T, VAL73T
• K-L: ARG11K, ARG37L, ARG38L, ARG54K, ARG66K, ARG66L, ASN42L, ASN43L, ASP21L, ASP25L, ASP51K, ASP58K, CYS62K, CYS80K, CYS80L, GLN75K, GLN75L, GLN9K, GLN9L, GLU13K, GLU22L, GLU46L, GLU61K, GLU84L, GLY15K, GLY20L, GLY72K, GLY72L, GLY74K, GLY74L, HIS23L, HIS82K, HIS82L, ILE10K, ILE55K, ILE6K, ILE6L, LEU28L, LEU4L, LEU57K, LEU5L, LEU60K, LEU68K, LEU68L, LEU77K, LEU77L, LEU81K, LEU81L, LYS59K, LYS83L, MET12K, MET18L, MET1L, MET29L, MET70K, MET70L, PHE44L, PHE65K, PHE65L, PRO26L, PRO2L, PRO52K, PRO53K, SER24L, SER69K, SER69L, SER7L, THR71K, THR71L, THR76K, THR76L, THR8K, THR8L, TRP79K, TRP79L, TYR3L, TYR45L, TYR47L, TYR48L, VAL14K, VAL19L, VAL39L, VAL56K, VAL67K, VAL67L, VAL73K, VAL73L, VAL78K, VAL78L
• K-M: GLY72K, GLY72M, LEU68K, MET70K, SER69K, SER69M, THR71K, THR71M
• K-N: GLY72K, GLY72N, MET70N, SER69K, SER69N, THR71K, THR71N
• K-O: ARG11O, ARG37K, ARG38K, ARG54O, ARG66K, ARG66O, ASN42K, ASN43K, ASN50O, ASP21K, ASP25K, ASP51O, ASP58O, CYS62O, CYS80K, CYS80O, GLN75K, GLN75O, GLN9K, GLN9O, GLU13O, GLU22K, GLU46K, GLU61O, GLU84K, GLY15O, GLY20K, GLY72K, GLY72O, GLY74K, GLY74O, HIS23K, HIS82K, HIS82O, ILE10O, ILE55O, ILE6K, ILE6O, LEU28K, LEU4K, LEU57O, LEU5K, LEU60O, LEU68K, LEU68O, LEU77K, LEU77O, LEU81K, LEU81O, LYS59O, LYS83K, MET12O, MET18K, MET1K, MET29K, MET70K, MET70O, PHE44K, PHE65K, PHE65O, PRO26K, PRO2K, PRO52O, PRO53O, SER24K, SER69K, SER69O, SER7K, THR17K, THR71K, THR71O, THR76K, THR76O, THR8K, THR8O, TRP79K, TRP79O, TYR3K, TYR45K, TYR47K, TYR48K, VAL14O, VAL19K, VAL39K, VAL56O, VAL67K, VAL67O, VAL73K, VAL73O, VAL78K, VAL78O
• L-M: ARG11L, ARG37M, ARG38M, ARG54L, ARG66L, ARG66M, ASN42M, ASN43M, ASN50L, ASP21M, ASP25M, ASP51L, ASP58L, CYS62L, CYS80L, CYS80M, GLN75L, GLN75M, GLN9L, GLN9M, GLU13L, GLU22M, GLU46M, GLU61L, GLU84M, GLY15L, GLY20M, GLY72L, GLY72M, GLY74L, GLY74M, HIS23M, HIS82L, HIS82M, ILE10L, ILE55L, ILE6L, ILE6M, LEU28M, LEU4M, LEU57L, LEU5M, LEU60L, LEU68L, LEU68M, LEU77L, LEU77M, LEU81L, LEU81M, LYS59L, LYS83M, MET12L, MET18M, MET1M, MET29M, MET70L, MET70M, PHE44M, PHE65L, PHE65M, PRO16M, PRO26M, PRO2M, PRO52L, PRO53L, SER24M, SER69L, SER69M, SER7M, THR17L, THR71L, THR71M, THR76L, THR76M, THR8L, THR8M, TRP79L, TRP79M, TYR3M, TYR45M, TYR47M, TYR48M, VAL14L, VAL19M, VAL39M, VAL56L, VAL67L, VAL67M, VAL73L, VAL73M, VAL78L, VAL78M
• L-N: GLY72L, GLY72N, MET70L, MET70N, SER69L, SER69N, THR71L, THR71N
• L-O: GLY72L, GLY72O, LEU68O, MET70L, MET70O, SER69L, SER69O, THR71L, THR71O
• M-N: ARG11M, ARG37N, ARG38N, ARG54M, ARG66M, ARG66N, ASN42N, ASN43N, ASP21N, ASP25N, ASP51M, ASP58M, CYS62M, CYS80M, CYS80N, GLN75M, GLN75N, GLN9M, GLN9N, GLU13M, GLU22N, GLU46N, GLU61M, GLU84N, GLY15M, GLY20N, GLY72M, GLY72N, GLY74M, GLY74N, HIS23N, HIS82M, HIS82N, ILE10M, ILE55M, ILE6M, ILE6N, LEU28N, LEU4N, LEU57M, LEU5N, LEU60M, LEU68M, LEU68N, LEU77M, LEU77N, LEU81M, LEU81N, LYS59M, LYS83N, MET12M, MET18N, MET1N, MET29N, MET70M, MET70N, PHE44N, PHE65M, PHE65N, PRO26N, PRO2N, PRO52M, PRO53M, SER24N, SER69M, SER69N, SER7N, THR17M, THR71M, THR71N, THR76M, THR76N, THR8M, THR8N, TRP79M, TRP79N, TYR3N, TYR45N, TYR47N, TYR48N, VAL14M, VAL19N, VAL39N, VAL56M, VAL67M, VAL67N, VAL73M, VAL73N, VAL78M, VAL78N
• M-O: GLY72M, GLY72O, MET70M, MET70O, SER69M, SER69O, THR71M, THR71O
• N-O: ARG11N, ARG37O, ARG38O, ARG54N, ARG66N, ARG66O, ASN42O, ASN43O, ASN50N, ASP21O, ASP25O, ASP51N, ASP58N, CYS62N, CYS80N, CYS80O, GLN75N, GLN75O, GLN9N, GLN9O, GLU13N, GLU22O, GLU46O, GLU61N, GLU84O, GLY15N, GLY20O, GLY72N, GLY72O, GLY74N, GLY74O, HIS23O, HIS82N, HIS82O, ILE10N, ILE55N, ILE6N, ILE6O, LEU28O, LEU4O, LEU57N, LEU5O, LEU60N, LEU68N, LEU68O, LEU77N, LEU77O, LEU81N, LEU81O, LYS59N, LYS83O, MET12N, MET18O, MET1O, MET29O, MET70N, MET70O, PHE44O, PHE65N, PHE65O, PRO26O, PRO2O, PRO52N, PRO53N, SER24O, SER69N, SER69O, SER7O, THR17N, THR71N, THR71O, THR76N, THR76O, THR8N, THR8O, TRP79N, TRP79O, TYR3O, TYR45O, TYR47O, TYR48O, VAL14N, VAL19O, VAL39O, VAL56N, VAL67N, VAL67O, VAL73N, VAL73O, VAL78N, VAL78O
• P-Q: ARG11P, ARG37Q, ARG38Q, ARG54P, ARG66P, ARG66Q, ASN42Q, ASN43Q, ASN50P, ASP21Q, ASP25Q, ASP51P, ASP58P, CYS62P, CYS80P, CYS80Q, GLN75P, GLN75Q, GLN9P, GLN9Q, GLU13P, GLU22Q, GLU46Q, GLU61P, GLU84Q, GLY15P, GLY20Q, GLY72P, GLY72Q, GLY74P, GLY74Q, HIS23Q, HIS82P, HIS82Q, ILE10P, ILE55P, ILE6P, ILE6Q, LEU28Q, LEU4Q, LEU57P, LEU5Q, LEU60P, LEU68P, LEU68Q, LEU77P, LEU77Q, LEU81P, LEU81Q, LYS59P, LYS83Q, MET12P, MET18Q, MET1Q, MET29Q, MET70P, MET70Q, PHE44Q, PHE65P, PHE65Q, PRO16Q, PRO26Q, PRO2Q, PRO52P, PRO53P, SER24Q, SER69P, SER69Q, SER7Q, THR71P, THR71Q, THR76P, THR76Q, THR8P, THR8Q, TRP79P, TRP79Q, TYR3Q, TYR45Q, TYR47Q, TYR48Q, VAL14P, VAL19Q, VAL39Q, VAL56P, VAL67P, VAL67Q, VAL73P, VAL73Q, VAL78P, VAL78Q
• P-R: GLY72P, GLY72R, LEU68P, MET70P, SER69P, SER69R, THR71P, THR71R
• P-S: GLY72P, GLY72S, MET70P, MET70S, SER69P, SER69S, THR71P, THR71S
• P-T: ARG11T, ARG37P, ARG38P, ARG54T, ARG66P, ARG66T, ASN42P, ASN43P, ASN50T, ASP21P, ASP25P, ASP51T, ASP58T, CYS62T, CYS80P, CYS80T, GLN75P, GLN75T, GLN9P, GLN9T, GLU13T, GLU22P, GLU46P, GLU61T, GLU84P, GLY15T, GLY20P, GLY72P, GLY72T, GLY74P, GLY74T, HIS23P, HIS82P, HIS82T, ILE10T, ILE55T, ILE6P, ILE6T, LEU28P, LEU4P, LEU57T, LEU5P, LEU60T, LEU68P, LEU68T, LEU77P, LEU77T, LEU81P, LEU81T, LYS59T, LYS83P, MET12T, MET18P, MET1P, MET29P, MET70P, MET70T, PHE44P, PHE65P, PHE65T, PRO26P, PRO2P, PRO52T, PRO53T, SER24P, SER69P, SER69T, SER7P, THR17P, THR71P, THR71T, THR76P, THR76T, THR8P, THR8T, TRP79P, TRP79T, TYR3P, TYR45P, TYR47P, TYR48P, VAL14T, VAL19P, VAL39P, VAL56T, VAL67P, VAL67T, VAL73P, VAL73T, VAL78P, VAL78T
• Q-R: ARG11Q, ARG37R, ARG38R, ARG54Q, ARG66Q, ARG66R, ASN42R, ASN43R, ASN50Q, ASP21R, ASP25R, ASP51Q, ASP58Q, CYS62Q, CYS80Q, CYS80R, GLN75Q, GLN75R, GLN9Q, GLN9R, GLU13Q, GLU22R, GLU46R, GLU61Q, GLU84R, GLY15Q, GLY20R, GLY72Q, GLY72R, GLY74Q, GLY74R, HIS23R, HIS82Q, HIS82R, ILE10Q, ILE55Q, ILE6Q, ILE6R, LEU28R, LEU4R, LEU57Q, LEU5R, LEU60Q, LEU68Q, LEU68R, LEU77Q, LEU77R, LEU81Q, LEU81R, LYS59Q, LYS83R, MET12Q, MET18R, MET1R, MET29R, MET70Q, MET70R, PHE44R, PHE65Q, PHE65R, PRO16R, PRO26R, PRO2R, PRO52Q, PRO53Q, SER24R, SER69Q, SER69R, SER7R, THR17R, THR71Q, THR71R, THR76Q, THR76R, THR8Q, THR8R, TRP79Q, TRP79R, TYR3R, TYR45R, TYR47R, TYR48R, VAL14Q, VAL19R, VAL39R, VAL56Q, VAL67Q, VAL67R, VAL73Q, VAL73R, VAL78Q, VAL78R
• Q-S: GLY72Q, GLY72S, MET70Q, MET70S, SER69Q, SER69S, THR71Q, THR71S
• Q-T: GLY72Q, GLY72T, MET70T, SER69Q, SER69T, THR71Q, THR71T
• R-S: ARG11R, ARG37S, ARG38S, ARG54R, ARG66R, ARG66S, ASN42S, ASN43S, ASN50R, ASP21S, ASP25S, ASP51R, ASP58R, CYS62R, CYS80R, CYS80S, GLN75R, GLN75S, GLN9R, GLN9S, GLU13R, GLU22S, GLU46S, GLU61R, GLU84S, GLY15R, GLY20S, GLY72R, GLY72S, GLY74R, GLY74S, HIS23S, HIS82R, HIS82S, ILE10R, ILE55R, ILE6R, ILE6S, LEU28S, LEU4S, LEU57R, LEU5S, LEU60R, LEU68R, LEU68S, LEU77R, LEU77S, LEU81R, LEU81S, LYS59R, LYS83S, MET12R, MET18S, MET1S, MET29S, MET70R, MET70S, PHE44S, PHE65R, PHE65S, PRO26S, PRO2S, PRO52R, PRO53R, SER24S, SER69R, SER69S, SER7S, THR71R, THR71S, THR76R, THR76S, THR8R, THR8S, TRP79R, TRP79S, TYR3S, TYR45S, TYR47S, TYR48S, VAL14R, VAL19S, VAL39S, VAL56R, VAL67R, VAL67S, VAL73R, VAL73S, VAL78R, VAL78S
• R-T: GLY72R, GLY72T, MET70R, MET70T, SER69R, SER69T, THR71R, THR71T
• S-T: ARG11S, ARG37T, ARG38T, ARG54S, ARG66S, ARG66T, ASN42T, ASN43T, ASN50S, ASP21T, ASP25T, ASP51S, ASP58S, CYS62S, CYS80S, CYS80T, GLN75S, GLN75T, GLN9S, GLN9T, GLU13S, GLU22T, GLU46T, GLU61S, GLU84T, GLY15S, GLY20T, GLY72S, GLY72T, GLY74S, GLY74T, HIS23T, HIS82S, HIS82T, ILE10S, ILE55S, ILE6S, ILE6T, LEU28T, LEU4T, LEU57S, LEU5T, LEU60S, LEU68S, LEU68T, LEU77S, LEU77T, LEU81S, LEU81T, LYS59S, LYS83T, MET12S, MET18T, MET1T, MET29T, MET70S, MET70T, PHE44T, PHE65S, PHE65T, PRO16T, PRO26T, PRO2T, PRO52S, PRO53S, SER24T, SER69S, SER69T, SER7T, THR17T, THR71S, THR71T, THR76S, THR76T, THR8S, THR8T, TRP79S, TRP79T, TYR3T, TYR45T, TYR47T, TYR48T, VAL14S, VAL19T, VAL39T, VAL56S, VAL67S, VAL67T, VAL73S, VAL73T, VAL78S, VAL78T