1WMK

human death-associated kinase drp-1, mutant s308d d40

• Total interactions analyzed: 28
• Total true interactions: 10
• Strongest Interaction:
  • Chains: A-E
  • Int. Res.: 150
  • Norm. En. per Res.: -1.7026
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-E	-11.3728	21.3876	-265.41	-255.3951	150	10	8	13151	2	58	69
A-C	-3.9932	-1.7518	-29.5235	-35.2685	45	4	0	2109	0	40	43
A-B	-8.0307	-5.8364	-40.7534	-54.6205	49	9	0	2414	0	25	20
E-C	0.0	0.0	-0.9223	-0.9223	15	0	0	139	0	6	2
C-B	0.0	28.0487	-254.972	-226.9233	148	6	8	12857	1	59	70
C-D	-29.666	-6.9984	-7.4871	-44.1514	39	5	0	1138	2	33	14
B-F	0.0	2.9803	-1.6647	1.3155	13	0	0	186	0	6	7
B-D	0.0	19.5638	-10.0863	9.4775	20	0	1	649	0	10	12
F-D	0.0	27.3698	-244.98	-217.6102	152	3	8	12789	2	58	70
H-G	0.0	25.6029	-275.361	-249.7581	151	6	9	13440	3	60	70

Interface residues

• A-E: ALA214A, ALA214E, ALA227A, ALA227E, ALA231A, ALA231E, ALA51A, ALA51E, ARG302A, ARG302E, ARG303A, ARG303E, ARG304A, ARG304E, ARG47A, ARG47E, ARG50A, ARG50E, ARG53A, ARG53E, ARG54A, ARG54E, ARG58A, ARG58E, ARG63A, ARG63E, ARG86A, ASN144E, ASN176A, ASN176E, ASN190A, ASN190E, ASN228A, ASN228E, ASN295E, ASP220A, ASP220E, ASP308E, ASP88A, GLN223A, GLN223E, GLN23A, GLN23E, GLN299A, GLN299E, GLN48A, GLN48E, GLU100A, GLU100E, GLU143A, GLU143E, GLU173A, GLU173E, GLU182A, GLU182E, GLU192A, GLU192E, GLU224A, GLU224E, GLU59A, GLU59E, GLU60A, GLU60E, GLY179A, GLY179E, GLY213A, GLY213E, GLY219A, GLY219E, GLY55A, HIS166A, HIS166E, ILE177A, ILE177E, ILE188A, ILE188E, ILE209E, ILE229A, ILE229E, ILE311E, ILE61A, ILE61E, LEU164A, LEU164E, LEU194A, LEU194E, LEU218A, LEU218E, LEU226A, LEU226E, LEU307E, LEU314E, LYS141A, LYS141E, LYS175A, LYS175E, LYS222A, LYS222E, LYS298A, LYS298E, LYS306E, LYS45A, LYS46A, PHE174A, PHE174E, PHE178A, PHE178E, PHE183A, PHE183E, PHE240A, PHE240E, PHE24A, PHE309E, PRO142A, PRO142E, PRO181A, PRO181E, PRO186A, PRO186E, SER215A, SER215E, SER310E, SER313E, SER49A, SER49E, SER52A, SER52E, SER57A, SER57E, THR180A, THR180E, THR221A, THR221E, THR225A, THR225E, THR230A, THR230E, THR87A, TRP305E, TYR191A, TYR191E, TYR300A, TYR300E, VAL184A, VAL184E, VAL189A, VAL189E, VAL312E, VAL56A, VAL56E
• A-C: ALA106A, ALA106C, ARG297A, ARG297C, ARG302A, ARG302C, ARG303A, ARG303C, ARG304A, ARG304C, ARG31A, ARG31C, ASN151A, ASP103C, ASP14C, GLN107A, GLN107C, GLN299C, GLU109A, GLU109C, GLU17A, GLU17C, GLU18A, GLU18C, GLU294A, GLU294C, GLU38A, GLU38C, GLY16A, GLY16C, ILE15A, ILE15C, LEU19A, LEU293A, LYS108A, LYS150C, LYS298A, LYS298C, LYS29A, LYS29C, SER110A, SER97A, TYR300C, VAL301A, VAL301C
• A-B: ALA283A, ARG286A, ARG287A, ARG297A, ARG47B, ARG53B, ARG54B, ARG86B, ASN151A, ASN280A, ASN85B, ASP11B, ASP279A, ASP88B, GLN107A, GLN243A, GLN281A, GLN282A, GLN48B, GLN6B, GLN7B, GLU109A, GLU10B, GLU113A, GLU114A, GLU115A, GLU288A, GLU84B, GLY55B, ILE26B, LEU111A, LYS108A, LYS28B, LYS45B, LYS46B, LYS8B, MET284A, PRO153A, SER110A, SER112A, SER289A, SER49B, SER52B, THR87B, TYR83B, VAL285A, VAL290A, VAL291A, VAL9B
• E-C: ARG287C, ARG54E, ARG86E, ASN151C, GLN107C, GLN48E, GLU109C, GLU115C, LEU111C, LYS108C, LYS8E, PRO153C, SER110C, SER49E, THR87E
• C-B: ALA214B, ALA214C, ALA227B, ALA227C, ALA231B, ALA231C, ALA51B, ALA51C, ARG302B, ARG302C, ARG303B, ARG303C, ARG304B, ARG304C, ARG47B, ARG47C, ARG50B, ARG50C, ARG53B, ARG53C, ARG54B, ARG54C, ARG58B, ARG58C, ARG63B, ARG63C, ARG86C, ASN144B, ASN144C, ASN176B, ASN176C, ASN190B, ASN190C, ASN228B, ASN228C, ASN295C, ASP220B, ASP220C, ASP308B, GLN223B, GLN223C, GLN23B, GLN23C, GLN299B, GLN299C, GLN48B, GLN48C, GLU100B, GLU100C, GLU143B, GLU143C, GLU173B, GLU173C, GLU182B, GLU182C, GLU192B, GLU192C, GLU224B, GLU224C, GLU59B, GLU59C, GLU60B, GLU60C, GLY179B, GLY179C, GLY213B, GLY213C, GLY219B, GLY219C, HIS166B, HIS166C, ILE177B, ILE177C, ILE188B, ILE188C, ILE209C, ILE229B, ILE229C, ILE311B, ILE61B, ILE61C, LEU164B, LEU164C, LEU194B, LEU194C, LEU218B, LEU218C, LEU226B, LEU226C, LEU307B, LYS141B, LYS141C, LYS175B, LYS175C, LYS222B, LYS222C, LYS298B, LYS298C, LYS306B, LYS45C, LYS46C, PHE174B, PHE174C, PHE178B, PHE178C, PHE183B, PHE183C, PHE240B, PHE240C, PHE24B, PHE309B, PRO142B, PRO142C, PRO181B, PRO181C, PRO186B, PRO186C, SER215B, SER215C, SER310B, SER313B, SER49B, SER49C, SER52B, SER52C, SER57B, SER57C, THR180B, THR180C, THR221B, THR221C, THR225B, THR225C, THR230B, THR230C, THR87C, TRP305B, TYR191B, TYR191C, TYR300B, TYR300C, VAL172C, VAL184B, VAL184C, VAL189B, VAL189C, VAL56B, VAL56C
• C-D: ALA227C, ALA231C, ARG253C, ARG253D, ARG261D, ARG271D, ASN228C, ASN280D, ASP220C, ASP235C, ASP237C, ASP250C, ASP250D, ASP279D, GLN281D, GLN282D, GLU224C, GLU238C, GLU239C, GLU246C, GLU259D, GLU268D, GLY219C, HIS272D, LEU247D, LEU264D, LYS249C, LYS254C, LYS254D, LYS262C, LYS262D, PHE236C, PRO273D, SER233C, THR221C, THR225C, TYR234C, VAL232C, VAL278D
• B-F: ARG261F, ASP170B, GLN70B, GLU169B, GLU173F, GLY171F, LEU72B, LYS133B, LYS134B, LYS175F, PRO193F, TYR129B, VAL172F
• B-D: ALA227D, ALA231D, ARG261D, ARG50B, ARG58B, ASN228D, ASP170B, GLU169B, GLU173B, GLU259D, GLU2B, GLU59B, GLU62B, GLY171B, LYS258D, LYS262D, SER233D, THR230D, VAL172B, VAL232D
• F-D: ALA214D, ALA214F, ALA227D, ALA227F, ALA231D, ALA231F, ALA51D, ALA51F, ARG302D, ARG302F, ARG303D, ARG303F, ARG304D, ARG304F, ARG47D, ARG47F, ARG50D, ARG50F, ARG53D, ARG53F, ARG54D, ARG54F, ARG58D, ARG58F, ARG63D, ARG63F, ARG86F, ASN144D, ASN144F, ASN176D, ASN176F, ASN190D, ASN190F, ASN228D, ASN228F, ASN295D, ASN295F, ASP220D, ASP220F, ASP308D, GLN223D, GLN223F, GLN23D, GLN23F, GLN299D, GLN299F, GLN48D, GLN48F, GLU100D, GLU100F, GLU143D, GLU143F, GLU173D, GLU173F, GLU182D, GLU182F, GLU192D, GLU192F, GLU224D, GLU224F, GLU59D, GLU59F, GLU60D, GLU60F, GLY179D, GLY179F, GLY213D, GLY213F, GLY219D, GLY219F, GLY55F, HIS166D, HIS166F, ILE177D, ILE177F, ILE188D, ILE188F, ILE209F, ILE229D, ILE229F, ILE311D, ILE61D, ILE61F, LEU164D, LEU164F, LEU194D, LEU194F, LEU218D, LEU218F, LEU226D, LEU226F, LEU307D, LEU314D, LYS141D, LYS141F, LYS175D, LYS175F, LYS222D, LYS222F, LYS298D, LYS298F, LYS306D, LYS45F, PHE174D, PHE174F, PHE178D, PHE178F, PHE183D, PHE183F, PHE240D, PHE240F, PHE24D, PHE309D, PRO142D, PRO142F, PRO181D, PRO181F, PRO186D, PRO186F, SER215D, SER215F, SER310D, SER313D, SER49D, SER49F, SER52D, SER52F, SER57D, SER57F, THR180D, THR180F, THR221D, THR221F, THR225D, THR225F, THR230D, THR230F, THR87F, TRP305D, TYR191D, TYR191F, TYR300D, TYR300F, VAL172F, VAL184D, VAL184F, VAL189D, VAL189F, VAL301D, VAL312D, VAL56D, VAL56F
• H-G: ALA214G, ALA214H, ALA227G, ALA227H, ALA231G, ALA231H, ALA51G, ALA51H, ARG302G, ARG302H, ARG303G, ARG303H, ARG304G, ARG304H, ARG47G, ARG47H, ARG50G, ARG50H, ARG53G, ARG53H, ARG54G, ARG54H, ARG58G, ARG58H, ARG63G, ARG63H, ARG86H, ASN144G, ASN144H, ASN176G, ASN176H, ASN190G, ASN190H, ASN228G, ASN228H, ASN295G, ASN295H, ASP220G, ASP220H, ASP308G, GLN223G, GLN223H, GLN23G, GLN23H, GLN299G, GLN299H, GLN48G, GLN48H, GLU100G, GLU100H, GLU143G, GLU143H, GLU173G, GLU173H, GLU182G, GLU182H, GLU192G, GLU192H, GLU224G, GLU224H, GLU59G, GLU59H, GLU60G, GLU60H, GLY179G, GLY179H, GLY213G, GLY213H, GLY219G, GLY219H, HIS166G, HIS166H, ILE177G, ILE177H, ILE188G, ILE188H, ILE209G, ILE229G, ILE229H, ILE311G, ILE61G, ILE61H, LEU164G, LEU164H, LEU194G, LEU194H, LEU218G, LEU218H, LEU226G, LEU226H, LEU307G, LYS141G, LYS141H, LYS175G, LYS175H, LYS222G, LYS222H, LYS298G, LYS298H, LYS306G, LYS45G, LYS45H, LYS46H, PHE174G, PHE174H, PHE178G, PHE178H, PHE183G, PHE183H, PHE240G, PHE240H, PHE24H, PHE309G, PRO142G, PRO142H, PRO181G, PRO181H, PRO186G, PRO186H, SER215G, SER215H, SER310G, SER313G, SER49G, SER49H, SER52G, SER52H, SER57G, SER57H, THR180G, THR180H, THR221G, THR221H, THR225G, THR225H, THR230G, THR230H, THR87H, TRP305G, TRP305H, TYR191G, TYR191H, TYR300G, TYR300H, VAL184G, VAL184H, VAL189G, VAL189H, VAL312G, VAL56G, VAL56H