1WF4

crystal structure of the chaperonin complex cpn60/cpn10/(adp)7 from thermus thermophilus

• Total interactions analyzed: 210
• Total true interactions: 56
• Strongest Interaction:
  • Chains: f-m
  • Int. Res.: 34
  • Norm. En. per Res.: -3.0603
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
a-b	-101.2115	-48.7501	-439.454	-589.4155	203	61	17	20603	7	82	75
a-g	-91.1277	-45.4832	-427.69	-564.3009	199	39	18	20188	7	76	79
a-h	-14.6621	-31.3305	-61.1651	-107.1576	45	2	2	2939	1	25	17
a-n	0.0	7.564			2
a-o	-37.6431	-4.4513			8
a-p	0.0	1.491			3
b-c	-95.5391	-65.34	-411.967	-572.846	202	44	18	19938	7	86	92
b-h	0.0	7.4011	-35.5138	-28.1127	27	2	1	1572	0	4	7
b-i	-10.3468	-28.7979	-61.9803	-101.125	44	2	2	2930	1	24	16
b-p	-8.3404	-4.5128			6
b-q	-3.0678	-0.9469			5
c-d	-99.5226	-47.4981	-417.695	-564.7157	197	35	16	19751	7	82	78
c-i	0.0	8.5708	-31.1954	-22.6246	24	0	1	1431	0	4	6
c-j	-10.6469	-28.8364	-65.4262	-104.9095	44	3	2	2950	1	25	16
c-q	-9.2573	-17.3659			7
c-r	-8.7765	1.102			4
d-e	-112.1863	-72.8213	-373.05	-558.0577	202	39	16	18897	8	89	93
d-j	0.0	8.5028	-27.8246	-19.3218	23	0	1	1356	0	3	6
d-k	0.0	-25.1416	-58.5118	-83.6534	44	2	2	2786	1	26	18
d-r	-5.8552	-5.2629			3
d-s	0.0	1.3			3
e-f	-90.0095	-37.9196	-418.13	-546.0591	202	57	17	20212	7	74	81
e-k	0.0	7.8488	-30.1625	-22.3137	24	0	1	1426	0	4	7
e-l	-7.6239	-26.1819	-70.4062	-104.212	45	3	3	3112	1	28	18
e-s	-54.2892	-48.6958			10
e-t	-9.9102	2.9005			3
f-g	-96.5426	-69.0265	-399.422	-564.9911	202	40	18	19437	6	88	90
f-l	0.0	8.0139	-28.6712	-20.6573	23	0	1	1343	0	4	7
f-m	-12.276	-31.1399	-60.6335	-104.0494	34	4	4	2452	0	12	10
f-t	-23.9824	-4.4881			8
f-u	0.0	1.7862			4
g-m	0.0	7.39	0.0	7.39	2	0	0	0	0	0	0
g-n	-14.5474	-31.5822			7
g-o	0.0	0.282			3
g-u	-33.5114	-1.7689			10
h-i	-84.1315	-71.6008	-286.201	-441.9333	160	17	12	13919	4	62	67
h-n	-71.1329	-78.5428			23
i-j	-64.2649	-75.1871	-322.072	-461.5239	165	16	14	14414	5	67	70
j-k	-83.8536	-73.5627	-326.329	-483.7453	168	18	13	14730	4	69	69
k-l	-86.4905	-68.6959	-306.576	-461.7625	165	23	12	14498	4	62	64
l-m	-102.3202	-66.8943	-138.82	-308.0346	108	17	4	6724	3	21	24
m-n	-88.7056	-74.2417			24
o-p	-77.8399	-1.6108			18
o-q	0.0	7.7643			2
o-t	0.0	11.6387			2
o-u	-47.5285	-21.1952			15
p-q	-74.8004	2.8356			19
p-r	0.0	7.5761			2
p-u	0.0	1.0692			2
q-r	-28.9519	15.0672			17
r-s	-76.7059	-8.7489			15
r-t	0.0	10.021			2
r-u	0.0	4.8239			2
s-t	-51.1534	44.1804			19
s-u	0.0	8.2181			2
t-u	-40.8993	-13.1109			15

Interface residues

• a-b: ALA108a, ALA111a, ALA115a, ALA12a, ALA22b, ALA24b, ALA259b, ALA26b, ALA343a, ALA360a, ALA382b, ALA383b, ALA3a, ALA458b, ALA483b, ALA509a, ALA510a, ALA514a, ALA521a, ALA524a, ALA57b, ALA71a, ALA71b, ALA78a, ARG118a, ARG13a, ARG267b, ARG283a, ARG284a, ARG344a, ARG34b, ARG367a, ARG36b, ARG379b, ARG394b, ARG503a, ASN106a, ASN112a, ASN153b, ASN206b, ASN21b, ASN25b, ASN264b, ASN346a, ASN37b, ASN457b, ASN508a, ASN68a, ASN68b, ASP154b, ASP282a, ASP356a, ASP435a, ASP64a, ASP64b, ASP83a, ASP9a, CB4.31182-3.96085, CB6.65746-16.21711, CB8.65483-9.36891, GLN507a, GLN72a, GLU10a, GLU121a, GLU208b, GLU211b, GLU223a, GLU286a, GLU302a, GLU303a, GLU351a, GLU353a, GLU385b, GLU387b, GLU390b, GLU41b, GLU436a, GLU520a, GLU525a, GLU59b, GLU61a, GLU61b, GLU63b, GLU76a, GLY110a, GLY19b, GLY268b, GLY281a, GLY305a, GLY32b, GLY347a, GLY35b, GLY459b, GLY45b, GLY513a, GLY70a, HIS65a, ILE199b, ILE348a, ILE49b, ILE512a, ILE516a, ILE5a, ILE69a, LEU114a, LEU116a, LEU16a, LEU182b, LEU258b, LEU261b, LEU266b, LEU288a, LEU304a, LEU31b, LEU352a, LEU364a, LEU388b, LEU40b, LEU506a, LEU515a, LEU517a, LEU62b, LEU66a, LEU6a, LEU73a, LEU74a, LYS117a, LYS132a, LYS180b, LYS265b, LYS285a, LYS289a, LYS28b, LYS326b, LYS349a, LYS350a, LYS389b, LYS391b, LYS42b, LYS43b, LYS4a, LYS4a9, LYS51b, LYS526a, LYS529a, LYS58b, LYS75a, LYS75b, LYS80a, MET210b, PHE306a, PHE44b, PHE8a, PRO113a, PRO155b, PRO201b, PRO207b, PRO33b, PRO47b, SER179b, SER181b, SER200b, SER301a, SER357a, SER46b, SER504a, SER511a, SER79a, THR209b, THR260b, THR30b, THR325b, THR354a, THR355a, THR384b, THR386b, THR48b, THR50b, THR518a, THR519a, THR55b, THR81a, TYR198b, TYR202b, VAL107a, VAL124a, VAL128a, VAL204b, VAL23b, VAL262b, VAL263b, VAL27b, VAL299a, VAL29b, VAL38b, VAL39b, VAL522a, VAL523a, VAL56b, VAL60b, VAL77a, VAL7a, VAL84a
• a-g: ALA108g, ALA111g, ALA115g, ALA12g, ALA22a, ALA24a, ALA259a, ALA26a, ALA292g, ALA293g, ALA343g, ALA382a, ALA383a, ALA3g, ALA458a, ALA483a, ALA509g, ALA510g, ALA514g, ALA521g, ALA524g, ALA57a, ALA71a, ALA71g, ALA78g, ARG118g, ARG13g, ARG267a, ARG344g, ARG34a, ARG36a, ARG394a, ARG503g, ASN106g, ASN112g, ASN153a, ASN206a, ASN21a, ASN25a, ASN264a, ASN346g, ASN37a, ASN457a, ASN508g, ASN68a, ASN68g, ASP154a, ASP290g, ASP340g, ASP435g, ASP64a, ASP64g, ASP83g, ASP9g, GLN507g, GLN72g, GLU10g, GLU121g, GLU208a, GLU211a, GLU256a, GLU286g, GLU302g, GLU303g, GLU339g, GLU342g, GLU351g, GLU353g, GLU385a, GLU387a, GLU390a, GLU41a, GLU520g, GLU525g, GLU528g, GLU59a, GLU61a, GLU61g, GLU63a, GLU76g, GLY110g, GLY19a, GLY255a, GLY297g, GLY305g, GLY32a, GLY347g, GLY35a, GLY45a, GLY513g, GLY70g, HIS65g, ILE341g, ILE345g, ILE348g, ILE49a, ILE512g, ILE516g, ILE5g, ILE69g, LEU114g, LEU116g, LEU16g, LEU182a, LEU258a, LEU266a, LEU288g, LEU304g, LEU352g, LEU364g, LEU388a, LEU40a, LEU506g, LEU515g, LEU517g, LEU62a, LEU66g, LEU6g, LEU73g, LEU74g, LYS117g, LYS132g, LYS180a, LYS285g, LYS289g, LYS28a, LYS326a, LYS338g, LYS349g, LYS350g, LYS389a, LYS391a, LYS42a, LYS43a, LYS4g, LYS51a, LYS526g, LYS58a, LYS75a, LYS75g, LYS80g, MET210a, MET315g, PHE306g, PHE44a, PHE8g, PRO113g, PRO155a, PRO201a, PRO207a, PRO33a, PRO47a, PRO527g, SER179a, SER181a, SER200a, SER301g, SER314g, SER46a, SER504g, SER511g, SER79g, THR205a, THR209a, THR260a, THR298g, THR30a, THR312g, THR325a, THR354g, THR384a, THR386a, THR48a, THR50a, THR518g, THR519g, THR55a, THR81g, TYR198a, TYR202a, VAL107g, VAL124g, VAL128g, VAL204a, VAL23a, VAL262a, VAL263a, VAL27a, VAL299g, VAL29a, VAL38a, VAL39a, VAL522g, VAL523g, VAL56a, VAL60a, VAL77g, VAL7g, VAL84g
• a-h: ALA108a, ALA108h, ALA109a, ALA109h, ALA111a, ALA111h, ALA11a, ALA437h, ARG101a, ARG13a, ARG14a, ARG14h, ARG444a, ARG444h, ASN106a, ASN106h, ASN112a, ASN112h, ASP435a, ASP435h, ASP9a, GLU102a, GLU102h, GLU10a, GLU10h, GLU17a, GLU433h, GLY103a, GLY110a, GLY110h, GLY434h, GLY439h, ILE429a, ILE442h, LEU104a, LEU116h, LEU432h, LYS105a, LYS105h, LYS441a, LYS441h, THR438a, THR438h, VAL107a, VAL107h
• a-n: GLU461a, GLU461n
• a-o: ARG267a, ASN264a, GLU237a, GLY28o, LYS25o, LYS27o, THR26o, VAL31o
• a-p: ASP34p, GLU309a, LYS307a
• b-c: ALA108b, ALA111b, ALA115b, ALA12b, ALA22c, ALA24c, ALA257c, ALA259c, ALA26c, ALA343b, ALA360b, ALA382c, ALA383c, ALA3b, ALA458c, ALA483c, ALA509b, ALA510b, ALA514b, ALA521b, ALA524b, ALA57c, ALA71b, ALA71c, ALA78b, ARG118b, ARG13b, ARG267c, ARG344b, ARG34c, ARG367b, ARG36c, ARG379c, ARG394c, ARG503b, ASN106b, ASN112b, ASN153c, ASN21c, ASN25c, ASN264c, ASN346b, ASN37c, ASN457c, ASN508b, ASN68b, ASN68c, ASP154c, ASP282b, ASP327c, ASP356b, ASP435b, ASP64b, ASP64c, ASP83b, ASP9b, GLN507b, GLN72b, GLU10b, GLU121b, GLU208c, GLU211c, GLU223b, GLU254c, GLU256c, GLU286b, GLU302b, GLU303b, GLU328c, GLU351b, GLU353b, GLU358b, GLU385c, GLU387c, GLU390c, GLU41c, GLU436b, GLU520b, GLU525b, GLU59c, GLU61b, GLU61c, GLU63c, GLU76b, GLY110b, GLY19c, GLY255c, GLY305b, GLY32c, GLY347b, GLY35c, GLY459c, GLY45c, GLY513b, GLY70b, HIS65b, ILE199c, ILE348b, ILE49c, ILE512b, ILE516b, ILE5b, ILE69b, LEU114b, LEU116b, LEU16b, LEU182c, LEU258c, LEU261c, LEU266c, LEU304b, LEU31c, LEU352b, LEU364b, LEU388c, LEU40c, LEU506b, LEU515b, LEU517b, LEU62c, LEU66b, LEU6b, LEU73b, LEU74b, LYS117b, LYS132b, LYS180c, LYS265c, LYS276c, LYS285b, LYS289b, LYS28c, LYS326c, LYS349b, LYS350b, LYS389c, LYS391c, LYS42c, LYS43c, LYS4b, LYS51c, LYS526b, LYS58c, LYS75b, LYS75c, LYS80b, MET210c, PHE306b, PHE44c, PHE8b, PRO113b, PRO155c, PRO201c, PRO207c, PRO33c, PRO47c, PRO527b, SER179c, SER181c, SER200c, SER301b, SER357b, SER46c, SER504b, SER511b, SER79b, THR209c, THR260c, THR298b, THR30c, THR325c, THR354b, THR355b, THR384c, THR386c, THR48c, THR50c, THR518b, THR519b, THR55c, THR81b, TYR198c, TYR202c, VAL107b, VAL124b, VAL128b, VAL23c, VAL253c, VAL262c, VAL263c, VAL27c, VAL299b, VAL29c, VAL38c, VAL39c, VAL522b, VAL523b, VAL56c, VAL60c, VAL77b, VAL7b, VAL84b
• b-h: ALA471h, ARG445b, ARG445h, ARG452b, ARG452h, GLN467b, GLN467h, GLN468b, GLN468h, GLU448h, GLU456b, GLU461b, GLU461h, GLY459b, GLY462b, GLY462h, ILE465b, ILE465h, ILE469h, LEU470h, PHE487h, SER463b, SER463h, TYR460b, VAL464b, VAL464h, VAL466h
• b-i: ALA108b, ALA108i, ALA109b, ALA109i, ALA111b, ALA111i, ALA11b, ALA437i, ARG101b, ARG13b, ARG14b, ARG14i, ARG444b, ARG444i, ASN106b, ASN106i, ASN112i, ASP435b, ASP435i, ASP9b, GLU102b, GLU102i, GLU10b, GLU10i, GLU17b, GLU433i, GLY103b, GLY110b, GLY110i, GLY434i, GLY439i, ILE429b, ILE442i, LEU104b, LEU116i, LEU432i, LYS105b, LYS105i, LYS441b, LYS441i, THR438b, THR438i, VAL107b, VAL107i
• b-p: ARG267b, GLU237b, GLY28p, LYS25p, LYS27p, THR26p
• b-q: ASP34q, LYS307b, LYS37q, PHE306b, THR35q
• c-d: ALA108c, ALA111c, ALA115c, ALA12c, ALA22d, ALA24d, ALA259d, ALA26d, ALA292c, ALA293c, ALA343c, ALA382d, ALA383d, ALA3c, ALA458d, ALA483d, ALA509c, ALA510c, ALA514c, ALA521c, ALA524c, ALA57d, ALA71c, ALA71d, ALA78c, ARG118c, ARG13c, ARG267d, ARG344c, ARG34d, ARG36d, ARG394d, ARG503c, ASN112c, ASN153d, ASN206d, ASN21d, ASN25d, ASN346c, ASN37d, ASN457d, ASN508c, ASN68c, ASN68d, ASP154d, ASP340c, ASP356c, ASP435c, ASP64c, ASP64d, ASP83c, ASP9c, GLN507c, GLN72c, GLU10c, GLU121c, GLU178d, GLU208d, GLU211d, GLU256d, GLU286c, GLU302c, GLU303c, GLU339c, GLU342c, GLU351c, GLU353c, GLU385d, GLU387d, GLU390d, GLU41d, GLU520c, GLU525c, GLU59d, GLU61c, GLU61d, GLU63d, GLU76c, GLY110c, GLY19d, GLY255d, GLY305c, GLY32d, GLY347c, GLY35d, GLY45d, GLY513c, GLY70c, HIS65c, ILE341c, ILE345c, ILE348c, ILE49d, ILE512c, ILE516c, ILE5c, ILE69c, LEU114c, LEU116c, LEU16c, LEU182d, LEU258d, LEU266d, LEU304c, LEU352c, LEU364c, LEU388d, LEU40d, LEU506c, LEU515c, LEU517c, LEU62d, LEU66c, LEU6c, LEU73c, LEU74c, LYS117c, LYS132c, LYS180d, LYS285c, LYS289c, LYS28d, LYS326d, LYS338c, LYS349c, LYS350c, LYS389d, LYS391d, LYS42d, LYS43d, LYS4c, LYS51d, LYS526c, LYS529c, LYS58d, LYS75c, LYS75d, LYS80c, MET210d, MET315c, PHE306c, PHE44d, PHE8c, PRO113c, PRO155d, PRO201d, PRO207d, PRO33d, PRO47d, PRO527c, SER179d, SER181d, SER200d, SER301c, SER314c, SER46d, SER504c, SER511c, SER79c, THR205d, THR209d, THR260d, THR298c, THR30d, THR312c, THR325d, THR354c, THR355c, THR384d, THR386d, THR48d, THR50d, THR518c, THR519c, THR55d, THR81c, TYR198d, TYR202d, VAL107c, VAL124c, VAL128c, VAL204d, VAL23d, VAL262d, VAL263d, VAL27d, VAL299c, VAL29d, VAL38d, VAL39d, VAL522c, VAL523c, VAL56d, VAL60d, VAL77c, VAL7c, VAL84c
• c-i: ALA471i, ARG445c, ARG445i, ARG452c, ARG452i, GLN467c, GLN467i, GLN468i, GLU448i, GLU456c, GLU461c, GLU461i, GLY459c, GLY462c, GLY462i, ILE465c, ILE465i, ILE469i, SER463c, SER463i, TYR460c, VAL464c, VAL464i, VAL466i
• c-j: ALA108c, ALA108j, ALA109c, ALA109j, ALA111c, ALA111j, ALA11c, ALA437j, ARG101c, ARG13c, ARG14c, ARG14j, ARG444c, ARG444j, ASN106c, ASN106j, ASN112j, ASP435c, ASP435j, ASP9c, GLU102c, GLU102j, GLU10c, GLU10j, GLU17c, GLU433j, GLY103c, GLY110c, GLY110j, GLY434j, GLY439j, ILE429c, ILE442j, LEU104c, LEU116j, LEU432j, LYS105c, LYS105j, LYS441c, LYS441j, THR438c, THR438j, VAL107c, VAL107j
• c-q: ARG230c, ASN264c, GLU237c, GLU38q, LYS27q, THR26q, VAL31q
• c-r: ASN310c, ASP34-8.7765303.123296, ASP34r, GLU309c
• d-e: ALA108d, ALA111d, ALA115d, ALA12d, ALA22e, ALA24e, ALA257e, ALA259e, ALA26e, ALA360d, ALA382e, ALA383e, ALA3d, ALA458e, ALA483e, ALA505d, ALA509d, ALA510d, ALA514d, ALA521d, ALA524d, ALA57e, ALA71d, ALA71e, ALA78d, ARG118d, ARG13d, ARG267e, ARG283d, ARG344d, ARG34e, ARG367d, ARG36e, ARG379e, ARG394e, ARG503d, ASN106d, ASN112d, ASN153e, ASN21e, ASN25e, ASN346d, ASN37e, ASN457e, ASN508d, ASN68d, ASN68e, ASP154e, ASP282d, ASP327e, ASP356d, ASP435d, ASP64d, ASP64e, ASP83d, ASP9d, GLN507d, GLN72d, GLU10d, GLU121d, GLU208e, GLU223d, GLU254e, GLU256e, GLU286d, GLU302d, GLU303d, GLU328e, GLU351d, GLU353d, GLU385e, GLU387e, GLU390e, GLU41e, GLU436d, GLU520d, GLU525d, GLU528d, GLU59e, GLU61d, GLU61e, GLU63e, GLU76d, GLY110d, GLY19e, GLY255e, GLY305d, GLY32e, GLY347d, GLY35e, GLY459e, GLY45e, GLY513d, GLY70d, HIS65d, ILE199e, ILE348d, ILE49e, ILE512d, ILE516d, ILE5d, ILE69d, LEU114d, LEU116d, LEU16d, LEU182e, LEU258e, LEU261e, LEU266e, LEU304d, LEU31e, LEU352d, LEU364d, LEU388e, LEU40e, LEU506d, LEU515d, LEU517d, LEU62e, LEU66d, LEU6d, LEU73d, LEU74d, LYS117d, LYS132d, LYS180e, LYS276e, LYS285d, LYS289d, LYS28e, LYS326e, LYS350d, LYS363d, LYS389e, LYS391e, LYS42e, LYS43e, LYS4d, LYS51e, LYS526d, LYS529d, LYS58e, LYS75d, LYS75e, LYS80d, MET210e, PHE203e, PHE306d, PHE44e, PHE8d, PRO113d, PRO155e, PRO201e, PRO207e, PRO33e, PRO47e, PRO527d, SER179e, SER181e, SER200e, SER301d, SER357d, SER46e, SER504d, SER511d, SER79d, THR209e, THR260e, THR298d, THR30e, THR325e, THR354d, THR355d, THR384e, THR386e, THR48e, THR50e, THR518d, THR519d, THR55e, THR81d, TYR198e, TYR202e, VAL107d, VAL124d, VAL128d, VAL23e, VAL253e, VAL262e, VAL263e, VAL27e, VAL299d, VAL29e, VAL38e, VAL39e, VAL522d, VAL523d, VAL56e, VAL60e, VAL77d, VAL7d, VAL84d
• d-j: ALA471j, ARG445d, ARG445j, ARG452d, ARG452j, GLN467d, GLN467j, GLN468j, GLU456d, GLU461d, GLU461j, GLY459d, GLY462d, GLY462j, ILE465d, ILE465j, ILE469j, SER463d, SER463j, TYR460d, VAL464d, VAL464j, VAL466j
• d-k: ALA108d, ALA108k, ALA109d, ALA109k, ALA111d, ALA111k, ALA11d, ALA437k, ARG101d, ARG13d, ARG14d, ARG14k, ARG444d, ARG444k, ASN106d, ASN106k, ASN112k, ASP435d, ASP435k, ASP9d, GLU102d, GLU102k, GLU10d, GLU10k, GLU17d, GLU433k, GLY103d, GLY110d, GLY110k, GLY434k, GLY439k, ILE429d, ILE442k, LEU104d, LEU116k, LYS105d, LYS105k, LYS441d, LYS441k, THR438d, THR438k, VAL100d, VAL107d, VAL107k
• d-r: GLU237d, GLY28-5.8552122.779058, LYS27r
• d-s: ASP34s, GLU309d, LYS307d
• e-f: ALA108e, ALA111e, ALA115e, ALA12e, ALA22f, ALA24f, ALA259f, ALA26f, ALA292e, ALA293e, ALA343e, ALA382f, ALA383f, ALA3e, ALA458f, ALA483f, ALA509e, ALA510e, ALA514e, ALA521e, ALA524e, ALA57f, ALA71e, ALA71f, ALA78e, ARG118e, ARG13e, ARG267f, ARG344e, ARG34f, ARG367e, ARG36f, ARG394f, ARG503e, ASN106e, ASN112e, ASN153f, ASN206f, ASN21f, ASN25f, ASN346e, ASN37f, ASN457f, ASN508e, ASN68e, ASN68f, ASP154f, ASP327f, ASP340e, ASP435e, ASP64e, ASP64f, ASP83e, ASP9e, GLN507e, GLN72e, GLU10e, GLU121e, GLU208f, GLU211f, GLU256f, GLU286e, GLU303e, GLU339e, GLU342e, GLU351e, GLU353e, GLU385f, GLU387f, GLU390f, GLU408e, GLU41f, GLU520e, GLU525e, GLU59f, GLU61e, GLU61f, GLU63f, GLU76e, GLY110e, GLY19f, GLY255f, GLY305e, GLY32f, GLY347e, GLY35f, GLY459f, GLY45f, GLY513e, GLY70e, HIS65e, ILE341e, ILE345e, ILE348e, ILE49f, ILE512e, ILE516e, ILE5e, ILE69e, LEU114e, LEU116e, LEU16e, LEU182f, LEU258f, LEU261f, LEU266f, LEU304e, LEU31f, LEU352e, LEU364e, LEU388f, LEU40f, LEU506e, LEU515e, LEU517e, LEU62f, LEU66e, LEU6e, LEU73e, LEU74e, LYS117e, LYS132e, LYS180f, LYS285e, LYS289e, LYS28f, LYS326f, LYS337e, LYS338e, LYS349e, LYS350e, LYS389f, LYS391f, LYS42f, LYS43f, LYS4e, LYS51f, LYS526e, LYS58f, LYS75e, LYS75f, LYS80e, MET210f, MET315e, PHE203f, PHE306e, PHE44f, PHE8e, PRO113e, PRO155f, PRO201f, PRO207f, PRO33f, PRO47f, PRO527e, SER179f, SER181f, SER200f, SER301e, SER314e, SER46f, SER504e, SER511e, SER79e, THR205f, THR209f, THR260f, THR298e, THR30f, THR312e, THR325f, THR354e, THR355e, THR384f, THR386f, THR48f, THR50f, THR518e, THR519e, THR55f, THR81e, TYR198f, TYR202f, VAL107e, VAL124e, VAL128e, VAL204f, VAL23f, VAL262f, VAL263f, VAL27f, VAL299e, VAL29f, VAL38f, VAL39f, VAL522e, VAL523e, VAL56f, VAL60f, VAL77e, VAL7e, VAL84e
• e-k: ALA471k, ARG445e, ARG445k, ARG452e, ARG452k, GLN467e, GLN467k, GLN468k, GLU448k, GLU456e, GLU461e, GLU461k, GLY459e, GLY462e, GLY462k, ILE465e, ILE465k, ILE469k, SER463e, SER463k, TYR460e, VAL464e, VAL464k, VAL466k
• e-l: ALA108e, ALA108l, ALA109e, ALA109l, ALA111e, ALA111l, ALA11e, ALA437l, ARG101e, ARG13e, ARG14e, ARG14l, ARG444e, ARG444l, ASN106e, ASN106l, ASN112l, ASP435e, ASP435l, ASP9e, GLU102e, GLU102l, GLU10e, GLU10l, GLU17e, GLU433l, GLY103e, GLY110e, GLY110l, GLY434l, GLY439l, ILE429e, ILE442l, LEU104e, LEU104l, LEU116l, LYS105e, LYS105l, LYS441e, LYS441l, THR438e, THR438l, VAL100e, VAL107e, VAL107l
• e-s: ARG230e, ARG267e, ASN264e, ASP34s, GLU237e, GLU256e, GLU38s, LYS25s, LYS27s, VAL31s
• e-t: ASP34t, GLU309e, LYS307e
• f-g: ALA108f, ALA111f, ALA115f, ALA12f, ALA22g, ALA24g, ALA257g, ALA259g, ALA26g, ALA360f, ALA382g, ALA383g, ALA3f, ALA458g, ALA483g, ALA505f, ALA509f, ALA510f, ALA514f, ALA521f, ALA524f, ALA57g, ALA71f, ALA71g, ALA78f, ARG118f, ARG13f, ARG267g, ARG344f, ARG34g, ARG367f, ARG36g, ARG379g, ARG394g, ARG503f, ASN106f, ASN112f, ASN153g, ASN21g, ASN25g, ASN264g, ASN346f, ASN37g, ASN457g, ASN508f, ASN68f, ASN68g, ASP154g, ASP282f, ASP327g, ASP356f, ASP435f, ASP64f, ASP64g, ASP83f, ASP9f, GLN507f, GLN72f, GLU10f, GLU121f, GLU178g, GLU208g, GLU211g, GLU223f, GLU254g, GLU256g, GLU286f, GLU302f, GLU303f, GLU351f, GLU353f, GLU358f, GLU385g, GLU387g, GLU390g, GLU41g, GLU436f, GLU520f, GLU525f, GLU528f, GLU59g, GLU61f, GLU61g, GLU63g, GLU76f, GLY110f, GLY19g, GLY255g, GLY305f, GLY32g, GLY347f, GLY35g, GLY459g, GLY45g, GLY513f, GLY70f, HIS65f, ILE199g, ILE348f, ILE49g, ILE512f, ILE516f, ILE5f, ILE69f, LEU114f, LEU116f, LEU16f, LEU182g, LEU258g, LEU261g, LEU266g, LEU304f, LEU31g, LEU352f, LEU364f, LEU388g, LEU40g, LEU506f, LEU515f, LEU517f, LEU62g, LEU66f, LEU6f, LEU73f, LEU74f, LYS117f, LYS132f, LYS180g, LYS276g, LYS285f, LYS289f, LYS28g, LYS326g, LYS350f, LYS389g, LYS391g, LYS42g, LYS43g, LYS4f, LYS51g, LYS526f, LYS529f, LYS58g, LYS75f, LYS75g, LYS80f, MET210g, PHE203g, PHE306f, PHE44g, PHE8f, PRO113f, PRO155g, PRO201g, PRO207g, PRO33g, PRO47g, PRO527f, SER179g, SER181g, SER200g, SER301f, SER357f, SER46g, SER504f, SER511f, SER79f, THR209g, THR260g, THR30g, THR325g, THR354f, THR355f, THR384g, THR386g, THR48g, THR50g, THR518f, THR519f, THR55g, THR81f, TYR198g, TYR202g, VAL107f, VAL124f, VAL128f, VAL23g, VAL253g, VAL262g, VAL263g, VAL27g, VAL299f, VAL29g, VAL38g, VAL39g, VAL522f, VAL523f, VAL56g, VAL60g, VAL77f, VAL7f, VAL84f
• f-l: ALA471l, ARG445f, ARG445l, ARG452f, ARG452l, GLN467f, GLN467l, GLN468l, GLU448l, GLU456f, GLU461f, GLU461l, GLY462f, GLY462l, ILE465f, ILE465l, ILE469l, SER463f, SER463l, TYR460f, VAL464f, VAL464l, VAL466l
• f-m: ALA108f, ALA108m, ALA109f, ALA109m, ALA111f, ALA111m, ALA11f, ARG101f, ARG13f, ARG14f, ARG14m, ASN106f, ASN106m, ASN112m, ASP435m, ASP9f, GLU102f, GLU102m, GLU10f, GLU10m, GLU17f, GLU433m, GLY103f, GLY110f, GLY110m, LEU104f, LEU104m, LEU116m, LYS105f, LYS105m, LYS441f, VAL100f, VAL107f, VAL107m
• f-t: ARG267f, ASN264f, GLU237f, GLY28t, LYS25t, LYS27t, THR26t, VAL31t
• f-u: ASP34u, GLU309f, LYS307f, LYS37u
• g-m: GLU461g, GLU461m
• g-n: ASP435n, ASP9g, GLU10g, GLU433n, LYS105g, LYS105n, LYS441g
• g-o: ASP34o, GLU309g, LYS307g
• g-u: ARG267g, ASN264g, GLU237g, GLU256g, GLY28u, LYS25u, LYS27u, LYS37u, THR26u, VAL31u
• h-i: ALA115i, ALA12i, ALA22h, ALA240h, ALA24h, ALA257i, ALA259i, ALA26h, ALA360i, ALA382h, ALA383h, ALA3i, ALA455h, ALA458h, ALA482h, ALA514i, ALA521i, ALA524i, ALA57h, ALA71h, ALA71i, ARG118i, ARG13i, ARG18h, ARG230i, ARG267h, ARG283i, ARG284i, ARG34h, ARG36h, ASN112i, ASN206h, ASN21h, ASN228i, ASN25h, ASN264h, ASN37h, ASN457h, ASN68h, ASN68i, ASP252i, ASP282i, ASP9i, GLN241h, GLN453h, GLN72i, GLU183h, GLU231i, GLU251i, GLU254i, GLU256i, GLU302i, GLU303i, GLU309i, GLU385h, GLU387h, GLU41h, GLU456h, GLU520i, GLU525i, GLU59h, GLU61h, GLU63h, GLU76i, GLY19h, GLY243h, GLY255i, GLY268h, GLY279i, GLY281i, GLY35h, GLY459h, GLY45h, GLY485h, GLY70i, HIS65i, ILE454h, ILE49h, ILE516i, ILE5i, ILE69i, LEU114i, LEU16i, LEU182h, LEU258i, LEU266h, LEU270h, LEU364i, LEU388h, LEU40h, LEU515i, LEU517i, LEU62h, LEU66i, LEU6i, LEU73i, LEU74i, LYS117i, LYS180h, LYS196i, LYS224i, LYS225i, LYS244h, LYS265h, LYS276i, LYS28h, LYS307i, LYS326i, LYS363i, LYS389h, LYS42h, LYS43h, LYS4i, LYS51h, LYS526i, LYS58h, LYS75h, PHE280i, PHE44h, PHE480h, PHE8i, PRO113i, PRO245h, PRO47h, PRO527i, SER179h, SER181h, SER227i, SER271h, SER357i, SER46h, THR205h, THR242h, THR269h, THR30h, THR384h, THR386h, THR48h, THR50h, THR518i, THR519i, THR55h, TYR359i, TYR460h, VAL107i, VAL213h, VAL226i, VAL229i, VAL23h, VAL263h, VAL27h, VAL29h, VAL38h, VAL39h, VAL522i, VAL523i, VAL56h, VAL60h, VAL77i, VAL7i
• h-n: ALA521h, ARG267n, ARG284h, ARG36n, ASP282h, GLU256h, GLU385n, GLU41n, GLU520h, GLU525h, GLU59n, GLU61n, GLU63n, HIS65h, LYS180n, LYS276h, LYS28n, LYS42n, LYS43n, LYS4h, LYS526h, VAL39n, VAL523h
• i-j: ALA115j, ALA12j, ALA22i, ALA240i, ALA24i, ALA257j, ALA259j, ALA26i, ALA360j, ALA382i, ALA383i, ALA3j, ALA455i, ALA458i, ALA514j, ALA521j, ALA524j, ALA57i, ALA71i, ALA71j, ARG118j, ARG13j, ARG18i, ARG230j, ARG267i, ARG283j, ARG284j, ARG34i, ARG36i, ASN112j, ASN206i, ASN21i, ASN228j, ASN25i, ASN264i, ASN37i, ASN457i, ASN68i, ASN68j, ASP252j, ASP282j, ASP64i, ASP9j, GLN241i, GLN453i, GLN72i, GLN72j, GLU183i, GLU215i, GLU223j, GLU231j, GLU251j, GLU254j, GLU256j, GLU302j, GLU303j, GLU309j, GLU385i, GLU387i, GLU41i, GLU456i, GLU520j, GLU525j, GLU59i, GLU61i, GLU63i, GLU76j, GLY19i, GLY243i, GLY255j, GLY268i, GLY279j, GLY281j, GLY35i, GLY381i, GLY459i, GLY45i, GLY485i, GLY70j, HIS65j, ILE49i, ILE516j, ILE5j, ILE69j, LEU114j, LEU16j, LEU182i, LEU258j, LEU266i, LEU270i, LEU308j, LEU364j, LEU388i, LEU40i, LEU515j, LEU517j, LEU62i, LEU66j, LEU6j, LEU73j, LEU74j, LYS117j, LYS180i, LYS196j, LYS224j, LYS225j, LYS244i, LYS265i, LYS276j, LYS285j, LYS28i, LYS307j, LYS326j, LYS363j, LYS389i, LYS42i, LYS43i, LYS4j, LYS51i, LYS526j, LYS58i, LYS75i, LYS75j, PHE280j, PHE44i, PHE8j, PRO113j, PRO245i, PRO47i, PRO527j, SER179i, SER181i, SER227j, SER271i, SER357j, SER46i, THR205i, THR242i, THR269i, THR30i, THR384i, THR386i, THR48i, THR50i, THR518j, THR519j, THR55i, TYR202j, TYR359j, TYR460i, VAL107j, VAL213i, VAL229j, VAL23i, VAL263i, VAL27i, VAL29i, VAL38i, VAL39i, VAL522j, VAL523j, VAL56i, VAL60i, VAL77j, VAL7j
• j-k: ALA115k, ALA12k, ALA22j, ALA240j, ALA24j, ALA257k, ALA259k, ALA26j, ALA360k, ALA382j, ALA383j, ALA3k, ALA455j, ALA458j, ALA514k, ALA521k, ALA524k, ALA57j, ALA71j, ALA71k, ARG118k, ARG13k, ARG18j, ARG230k, ARG267j, ARG283k, ARG284k, ARG34j, ARG36j, ASN112k, ASN206j, ASN21j, ASN228k, ASN25j, ASN264j, ASN37j, ASN457j, ASN68j, ASN68k, ASP252k, ASP282k, ASP64j, ASP9k, GLN241j, GLN453j, GLN72j, GLN72k, GLU183j, GLU215j, GLU223k, GLU231k, GLU251k, GLU254k, GLU256k, GLU302k, GLU303k, GLU309k, GLU385j, GLU387j, GLU41j, GLU456j, GLU520k, GLU525k, GLU59j, GLU61j, GLU63j, GLU76k, GLY19j, GLY243j, GLY255k, GLY268j, GLY279k, GLY281k, GLY35j, GLY459j, GLY45j, GLY485j, GLY70k, HIS65k, ILE454j, ILE49j, ILE512k, ILE516k, ILE5k, ILE69k, LEU114k, LEU16k, LEU182j, LEU258k, LEU266j, LEU270j, LEU308k, LEU364k, LEU388j, LEU40j, LEU515k, LEU517k, LEU62j, LEU66k, LEU6k, LEU73k, LEU74k, LYS117k, LYS180j, LYS196k, LYS224k, LYS225k, LYS244j, LYS265j, LYS276k, LYS285k, LYS28j, LYS307k, LYS326k, LYS363k, LYS389j, LYS42j, LYS43j, LYS4k, LYS51j, LYS526k, LYS58j, LYS75j, LYS75k, PHE280k, PHE44j, PHE8k, PRO113k, PRO245j, PRO47j, PRO527k, SER179j, SER181j, SER227k, SER271j, SER357k, SER46j, SER511k, THR205j, THR242j, THR269j, THR30j, THR384j, THR386j, THR48j, THR50j, THR518k, THR519k, THR55j, TYR202k, TYR359k, TYR460j, VAL107k, VAL213j, VAL226k, VAL229k, VAL23j, VAL263j, VAL27j, VAL29j, VAL38j, VAL39j, VAL522k, VAL523k, VAL56j, VAL60j, VAL77k, VAL7k
• k-l: ALA115l, ALA12l, ALA22k, ALA240k, ALA24k, ALA257l, ALA26k, ALA360l, ALA382k, ALA383k, ALA3l, ALA455k, ALA458k, ALA482k, ALA514l, ALA521l, ALA524l, ALA57k, ALA71k, ALA71l, ARG118l, ARG13l, ARG18k, ARG230l, ARG267k, ARG283l, ARG284l, ARG34k, ARG36k, ASN112l, ASN206k, ASN21k, ASN228l, ASN25k, ASN264k, ASN37k, ASN457k, ASN68k, ASN68l, ASP252l, ASP282l, ASP356l, ASP64k, ASP9l, GLN241k, GLN453k, GLN72l, GLU183k, GLU231l, GLU251l, GLU254l, GLU256l, GLU302l, GLU303l, GLU309l, GLU385k, GLU387k, GLU41k, GLU456k, GLU520l, GLU525l, GLU59k, GLU61k, GLU63k, GLU76l, GLY19k, GLY243k, GLY255l, GLY268k, GLY279l, GLY281l, GLY35k, GLY459k, GLY45k, GLY485k, GLY70l, HIS65l, ILE454k, ILE49k, ILE512l, ILE516l, ILE5l, ILE69l, LEU114l, LEU16l, LEU182k, LEU266k, LEU270k, LEU364l, LEU388k, LEU40k, LEU515l, LEU517l, LEU62k, LEU66l, LEU6l, LEU73l, LEU74l, LYS117l, LYS180k, LYS196l, LYS224l, LYS225l, LYS244k, LYS265k, LYS276l, LYS28k, LYS307l, LYS326l, LYS363l, LYS389k, LYS42k, LYS43k, LYS4l, LYS51k, LYS526l, LYS58k, LYS75k, LYS75l, PHE280l, PHE44k, PHE480k, PHE8l, PRO113l, PRO207k, PRO245k, PRO47k, PRO527l, SER179k, SER181k, SER227l, SER271k, SER357l, SER46k, SER511l, THR205k, THR242k, THR269k, THR30k, THR384k, THR386k, THR48k, THR50k, THR518l, THR519l, THR55k, TYR202l, TYR359l, TYR460k, VAL107l, VAL213k, VAL226l, VAL229l, VAL23k, VAL263k, VAL27k, VAL29k, VAL38k, VAL39k, VAL522l, VAL523l, VAL56k, VAL60k, VAL77l, VAL7l
• l-m: ALA115m, ALA12m, ALA22l, ALA24l, ALA26l, ALA383l, ALA3m, ALA455l, ALA458l, ALA521m, ALA57l, ALA71l, ALA71m, ARG118m, ARG13m, ARG18l, ARG267l, ARG284m, ARG34l, ARG36l, ASN112m, ASN21l, ASN228m, ASN25l, ASN37l, ASN457l, ASN68l, ASN68m, ASP216l, ASP282m, ASP64l, ASP64m, ASP9m, GLN241l, GLN72l, GLN72m, GLU183l, GLU215l, GLU231m, GLU251m, GLU256m, GLU302m, GLU385l, GLU41l, GLU456l, GLU520m, GLU525m, GLU59l, GLU61l, GLU61m, GLU63l, GLU76m, GLY19l, GLY268l, GLY35l, GLY459l, GLY45l, GLY485l, GLY70m, HIS65m, ILE454l, ILE49l, ILE5m, ILE69m, LEU114m, LEU16m, LEU40l, LEU62l, LEU66m, LEU6m, LEU73m, LEU74m, LYS117m, LYS180l, LYS196m, LYS224m, LYS225m, LYS244l, LYS276m, LYS28l, LYS42l, LYS43l, LYS4m, LYS51l, LYS526m, LYS58l, LYS75l, LYS75m, PHE44l, PHE8m, PRO113m, PRO47l, SER46l, THR384l, THR48l, THR518m, TYR460l, VAL107m, VAL23l, VAL27l, VAL29l, VAL38l, VAL39l, VAL523m, VAL56l, VAL60l, VAL77m, VAL7m
• m-n: ALA521n, ARG267m, ARG284n, ARG36m, ASN37m, ASP282n, GLU256n, GLU385m, GLU41m, GLU520n, GLU525n, GLU59m, GLU61m, GLU63m, HIS65n, LYS180m, LYS276n, LYS42m, LYS43m, LYS4n, LYS526n, THR518n, VAL39m, VAL523n
• o-p: ARG14p, ARG52o, ARG59p, ARG93o, ASP68o, GLN100o, GLU55o, GLU55p, GLU63o, GLU81p, GLU85p, GLY12p, LEU95o, LYS27o, LYS9p, VAL53p, VAL7p, VAL98o
• o-q: GLU55o, GLU55q
• o-t: GLU55o, GLU55t
• o-u: ARG14o, ARG59o, ARG93u, ASP68u, ASP83o, GLN100u, GLU55o, GLU55u, GLU63u, GLU81o, GLU85o, LYS27u, LYS9o, VAL7o, VAL98u
• p-q: ARG14q, ARG52p, ARG93p, ASN56p, ASN56q, ASP68p, GLN100p, GLU55p, GLU55q, GLU81q, GLU85q, LEU11q, LEU95p, LEU96p, LYS27p, LYS9q, VAL53q, VAL7q, VAL98p
• p-r: GLU55p, GLU55r
• p-u: GLU55p, GLU55u
• q-r: 7-7.4401972.843753VAL, 9-8.3973842.743159LYS, ARG14-8.8762892.459637, ARG93q, ASP68q, ASP83r, GLN100q, GLU23q, GLU38q, GLU55q, GLU55r, GLU81r, LEU11-4.2379903.205774, LEU96q, LYS27q, LYS9r, VAL98q
• r-s: ARG59s, ARG93-2.8372232.816580, ASN56-27.6425622.225133, ASP68r, GLN100-11.0944902.821527, GLN100-13.0509422.858841, GLU55r, GLU55s, GLU63r, GLU81s, GLU85s, LYS27r, LYS9s, VAL98-13.5638112.685909, VAL98-8.5168912.680161
• r-t: GLU55r, GLU55t
• r-u: GLU55r, GLU55u
• s-t: ARG14t, ARG93s, ASN56s, ASP68s, ASP83t, GLN100s, GLU22s, GLU23s, GLU55s, GLU55t, GLU81t, GLU85t, LEU11t, LEU95s, LEU96s, LYS27s, LYS9t, VAL7t, VAL98s
• s-u: GLU55s, GLU55u
• t-u: ARG14u, ARG52t, ARG59u, ARG93t, ASN56t, ASN56u, ASP68t, GLU55t, GLU55u, GLU63t, GLU81u, LEU95t, LYS27t, LYS9u, VAL98t