1WE3

crystal structure of the chaperonin complex cpn60/cpn10/(adp)7 from thermus thermophilus

• Total interactions analyzed: 210
• Total true interactions: 54
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 193
  • Norm. En. per Res.: -3.1842
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-119.183	-90.936	-404.426	-614.5449	193	45	17	19554	10	90	91
A-G	-99.9226	-51.537	-418.957	-570.4167	202	51	17	20294	6	77	80
A-H	-12.5626	-29.8909	-62.264	-104.7174	45	3	2	2836	1	24	16
A-N	0.0	7.3234			2
A-O	-12.2628	-4.2643			7
A-P	0.0	2.4926			4
B-C	-89.8456	-38.2091	-411.62	-539.6747	202	45	17	19782	6	79	81
B-H	0.0	8.2363	-30.6279	-22.3916	24	0	1	1423	0	4	6
B-I	-11.2833	-29.8033	-61.8737	-102.9603	44	2	2	2873	1	24	16
B-P	-17.2241	-45.9997			8
B-Q	0.0	1.9278			3
C-D	-95.9939	-65.235	-388.193	-549.4218	205	41	17	19249	7	79	93
C-I	-2.5006	8.6495	-34.6877	-28.5389	24	0	1	1524	0	4	7
C-J	-14.2178	-31.1	-65.2792	-110.5969	46	2	2	3079	1	25	18
C-Q	-18.3484	-5.0522			7
C-R	0.0	0.2571			3
D-E	-97.2127	-61.9784	-387.803	-546.9942	195	47	17	19364	7	81	92
D-J	0.0	7.8372	-36.2735	-28.4363	27	0	1	1606	0	4	7
D-K	-8.2481	-25.9652	-58.5466	-92.7599	44	2	2	2889	1	25	17
D-R	-20.4217	-3.3385			9
D-S	-7.0104	-1.3677			4
E-F	-93.7622	-45.0651	-432.088	-570.9152	201	50	18	20518	8	78	88
E-K	-6.1809	8.8168	-30.585	-27.949	22	0	1	1407	0	3	7
E-L	0.0	-25.0324	-61.696	-86.7284	46	4	2	2942	1	29	18
E-S	-11.1746	-6.052			6
E-T	0.0	-0.5458			3
F-G	-123.1001	-70.9825	-408.809	-602.8916	206	51	17	20193	8	86	95
F-L	-6.4687	8.4312	-29.6405	-27.678	24	0	1	1377	0	3	7
F-M	-10.4892	-29.5905	-60.7478	-100.8276	34	3	4	2551	0	13	12
F-T	-21.1472	-4.0922			7
F-U	0.0	1.5119			3
G-M	0.0	7.2409	0.0	7.2409	2	0	0	0	0	0	0
G-N	-11.8234	-29.4905			7
G-O	-9.1122	1.6597			4
G-U	-19.9058	-1.2573			8
H-I	-93.1384	-72.2356	-312.47	-477.844	157	16	13	14096	4	64	68
H-N	-86.7527	-90.1212			25
I-J	-71.2086	-82.6709	-321.492	-475.3715	165	17	14	14563	5	64	66
J-K	-76.3634	-81.201	-294.472	-452.0364	163	18	12	13935	4	66	69
K-L	-78.1796	-83.4261	-296.952	-458.5578	169	19	12	14350	5	65	67
L-M	-103.532	-59.8022	-146.378	-309.7122	113	35	6	7316	3	22	25
M-N	-92.2689	-91.5319			29
O-P	-94.0165	-7.33			19
O-Q	0.0	11.7212			2
O-T	0.0	9.067			2
O-U	-39.7292	12.8423			17
P-Q	-45.6898	14.6241			18
P-R	0.0	8.9491			2
Q-R	-72.5696	11.402			15
Q-S	0.0	7.2635			2
R-S	-69.3781	11.3382			14
S-T	-62.2745	10.2196			15
S-U	0.0	14.6831			2
T-U	-46.0264	27.475			15

Interface residues

• A-B: ALA108A, ALA111A, ALA115A, ALA12A, ALA22B, ALA24B, ALA257B, ALA259B, ALA26B, ALA360A, ALA382B, ALA383B, ALA3A, ALA458B, ALA483B, ALA509A, ALA510A, ALA514A, ALA521A, ALA524A, ALA57B, ALA71A, ALA71B, ALA78A, ARG118A, ARG13A, ARG283A, ARG344A, ARG34B, ARG367A, ARG36B, ARG379B, ARG394B, ARG503A, ASN112A, ASN153B, ASN21B, ASN25B, ASN346A, ASN37B, ASN457B, ASN508A, ASN68A, ASN68B, ASP154B, ASP282A, ASP327B, ASP356A, ASP435A, ASP64A, ASP64B, ASP83A, ASP9A, GLN507A, GLN72A, GLU10A, GLU121A, GLU208B, GLU223A, GLU254B, GLU256B, GLU286A, GLU302A, GLU303A, GLU351A, GLU353A, GLU358A, GLU385B, GLU387B, GLU390B, GLU41B, GLU520A, GLU525A, GLU528B, GLU59B, GLU61A, GLU61B, GLU63B, GLU76A, GLY110A, GLY19B, GLY255B, GLY305A, GLY32B, GLY347A, GLY35B, GLY45B, GLY513A, GLY70A, HIS65A, ILE199B, ILE348A, ILE49B, ILE512A, ILE516A, ILE5A, ILE69A, LEU114A, LEU116A, LEU16A, LEU182B, LEU258B, LEU266B, LEU304A, LEU352A, LEU364A, LEU388B, LEU40B, LEU506A, LEU515A, LEU517A, LEU62B, LEU66A, LEU6A, LEU73A, LEU74A, LYS117A, LYS132A, LYS180B, LYS276B, LYS285A, LYS289A, LYS28B, LYS326B, LYS350A, LYS363A, LYS389B, LYS391B, LYS42B, LYS43B, LYS4A, LYS51B, LYS526A, LYS529A, LYS58B, LYS75A, LYS75B, LYS80A, MET210B, PHE203B, PHE306A, PHE44B, PHE8A, PRO113A, PRO155B, PRO201B, PRO207B, PRO33B, PRO47B, SER179B, SER181B, SER200B, SER301A, SER357A, SER46B, SER504A, SER511A, SER79A, THR209B, THR260B, THR30B, THR325B, THR354A, THR355A, THR384B, THR386B, THR48B, THR50B, THR518A, THR519A, THR55B, THR81A, TYR198B, TYR202B, VAL107A, VAL124A, VAL128A, VAL23B, VAL253B, VAL262B, VAL263B, VAL27B, VAL299A, VAL29B, VAL38B, VAL39B, VAL522A, VAL523A, VAL56B, VAL60B, VAL77A, VAL7A, VAL84A
• A-G: ALA108G, ALA111G, ALA115G, ALA12G, ALA22A, ALA24A, ALA259A, ALA26A, ALA292G, ALA293G, ALA343G, ALA382A, ALA383A, ALA3G, ALA458A, ALA482A, ALA483A, ALA505G, ALA509G, ALA510G, ALA514G, ALA521G, ALA524G, ALA57A, ALA71A, ALA71G, ALA78G, ARG118G, ARG13G, ARG267A, ARG344G, ARG34A, ARG36A, ARG394A, ARG503G, ASN106G, ASN112G, ASN153A, ASN206A, ASN21A, ASN25A, ASN346G, ASN37A, ASN457A, ASN508G, ASN68A, ASN68G, ASP154A, ASP327A, ASP340G, ASP435G, ASP64A, ASP64G, ASP83G, ASP9G, GLN507G, GLN72G, GLU10G, GLU121G, GLU156A, GLU208A, GLU211A, GLU256A, GLU286G, GLU303G, GLU339G, GLU342G, GLU351G, GLU353G, GLU385A, GLU387A, GLU390A, GLU41A, GLU436G, GLU520G, GLU525G, GLU59A, GLU61A, GLU61G, GLU63A, GLU76G, GLY110G, GLY19A, GLY255A, GLY305G, GLY32A, GLY347G, GLY35A, GLY459A, GLY45A, GLY513G, GLY70G, HIS65G, ILE341G, ILE345G, ILE348G, ILE49A, ILE512G, ILE516G, ILE5G, ILE69G, LEU114G, LEU116G, LEU16G, LEU182A, LEU258A, LEU261A, LEU266A, LEU304G, LEU31A, LEU352G, LEU364G, LEU388A, LEU40A, LEU506G, LEU515G, LEU517G, LEU62A, LEU66G, LEU6G, LEU73G, LEU74G, LYS117G, LYS132G, LYS180A, LYS289G, LYS28A, LYS326A, LYS337G, LYS338G, LYS349G, LYS350G, LYS389A, LYS391A, LYS42A, LYS43A, LYS4G, LYS51A, LYS526G, LYS58A, LYS75A, LYS75G, LYS80G, MET210A, MET315G, PHE203A, PHE306G, PHE44A, PHE8G, PRO113G, PRO155A, PRO201A, PRO207A, PRO33A, PRO47A, SER179A, SER181A, SER200A, SER301G, SER314G, SER46A, SER504G, SER511G, SER79G, THR205A, THR209A, THR260A, THR298G, THR30A, THR312G, THR325A, THR354G, THR355G, THR384A, THR386A, THR48A, THR50A, THR518G, THR519G, THR55A, THR81G, TYR198A, TYR202A, VAL107G, VAL124G, VAL128G, VAL204A, VAL23A, VAL262A, VAL263A, VAL27A, VAL299G, VAL29A, VAL38A, VAL39A, VAL522G, VAL523G, VAL56A, VAL60A, VAL77G, VAL7G, VAL84G
• A-H: ALA108A, ALA108H, ALA109A, ALA109H, ALA111A, ALA111H, ALA11A, ALA437H, ARG101A, ARG13A, ARG14A, ARG14H, ARG444A, ARG444H, ASN106A, ASN106H, ASN112H, ASP435A, ASP435H, ASP9A, GLU102A, GLU102H, GLU10A, GLU10H, GLU17A, GLU433H, GLY103A, GLY110A, GLY110H, GLY434A, GLY434H, GLY439H, ILE429A, ILE442H, LEU104A, LEU116H, LEU432H, LYS105A, LYS105H, LYS441A, LYS441H, THR438A, THR438H, VAL107A, VAL107H
• A-N: GLU461A, GLU461N
• A-O: ARG267A, ASN264A, GLU237A, GLY28O, LYS25O, LYS27O, VAL31O
• A-P: ASP34P, GLU309A, LYS307A, LYS37P
• B-C: ALA108B, ALA111B, ALA115B, ALA12B, ALA22C, ALA24C, ALA259C, ALA26C, ALA292B, ALA293B, ALA343B, ALA382C, ALA383C, ALA3B, ALA458C, ALA483C, ALA509B, ALA510B, ALA514B, ALA521B, ALA524B, ALA57C, ALA71B, ALA71C, ALA78B, ARG118B, ARG13B, ARG267C, ARG344B, ARG34C, ARG36C, ARG394C, ARG503B, ASN112B, ASN153C, ASN206C, ASN21C, ASN25C, ASN346B, ASN37C, ASN457C, ASN508B, ASN68B, ASN68C, ASP154C, ASP327C, ASP340B, ASP435B, ASP64B, ASP64C, ASP83B, ASP9B, GLN507B, GLN72B, GLU10B, GLU121B, GLU208C, GLU211C, GLU223B, GLU256C, GLU286B, GLU302B, GLU303B, GLU339B, GLU342B, GLU351B, GLU353B, GLU385C, GLU387C, GLU390C, GLU41C, GLU520B, GLU525B, GLU59C, GLU61B, GLU61C, GLU63C, GLU76B, GLY110B, GLY19C, GLY255C, GLY305B, GLY32C, GLY347B, GLY35C, GLY459C, GLY45C, GLY513B, GLY70B, HIS65B, ILE341B, ILE345B, ILE348B, ILE49C, ILE512B, ILE516B, ILE5B, ILE69B, LEU114B, LEU116B, LEU16B, LEU182C, LEU258C, LEU261C, LEU266C, LEU304B, LEU31C, LEU352B, LEU364B, LEU388C, LEU40C, LEU506B, LEU515B, LEU517B, LEU62C, LEU66B, LEU6B, LEU73B, LEU74B, LYS117B, LYS132B, LYS180C, LYS265C, LYS285B, LYS289B, LYS28C, LYS326C, LYS337B, LYS338B, LYS349B, LYS350B, LYS389C, LYS391C, LYS42C, LYS43C, LYS4B, LYS51C, LYS526B, LYS529B, LYS58C, LYS75B, LYS75C, LYS80B, MET210C, MET315B, PHE203C, PHE306B, PHE44C, PHE8B, PRO113B, PRO155C, PRO201C, PRO207C, PRO33C, PRO47C, SER179C, SER181C, SER200C, SER301B, SER314B, SER46C, SER504B, SER511B, SER79B, THR205C, THR209C, THR260C, THR298B, THR30C, THR312B, THR325C, THR354B, THR355B, THR384C, THR386C, THR48C, THR50C, THR518B, THR519B, THR55C, THR81B, TYR198C, TYR202C, VAL107B, VAL124B, VAL128B, VAL204C, VAL23C, VAL262C, VAL263C, VAL27C, VAL299B, VAL29C, VAL38C, VAL39C, VAL522B, VAL523B, VAL56C, VAL60C, VAL77B, VAL7B, VAL84B
• B-H: ALA471H, ARG445B, ARG445H, ARG452B, ARG452H, GLN467B, GLN467H, GLN468H, GLU448H, GLU456B, GLU461B, GLU461H, GLY459B, GLY462B, GLY462H, ILE465B, ILE465H, ILE469H, SER463B, SER463H, TYR460B, VAL464B, VAL464H, VAL466H
• B-I: ALA108B, ALA108I, ALA109B, ALA109I, ALA111B, ALA111I, ALA11B, ALA437I, ARG101B, ARG13B, ARG14B, ARG14I, ARG444B, ARG444I, ASN106B, ASN106I, ASN112I, ASP435B, ASP435I, ASP9B, GLU102B, GLU102I, GLU10B, GLU10I, GLU17B, GLU433I, GLY103B, GLY110B, GLY110I, GLY434I, GLY439I, ILE429B, ILE442I, LEU104B, LEU116I, LEU432I, LYS105B, LYS105I, LYS441B, LYS441I, THR438B, THR438I, VAL107B, VAL107I
• B-P: ARG230B, ARG267B, ASN264B, GLU237B, GLU38P, LYS25P, LYS27P, VAL31P
• B-Q: ASP34Q, GLU309B, LYS307B
• C-D: ALA108C, ALA111C, ALA115C, ALA12C, ALA22D, ALA24D, ALA259D, ALA26D, ALA343C, ALA360C, ALA382D, ALA383D, ALA3C, ALA458D, ALA483D, ALA509C, ALA510C, ALA514C, ALA521C, ALA524C, ALA57D, ALA71C, ALA71D, ARG118C, ARG13C, ARG267D, ARG283C, ARG344C, ARG34D, ARG361C, ARG367C, ARG36D, ARG379D, ARG394D, ARG503C, ASN106C, ASN112C, ASN153D, ASN206D, ASN21D, ASN25D, ASN264D, ASN346C, ASN37D, ASN457D, ASN508C, ASN68C, ASN68D, ASP154D, ASP282C, ASP327D, ASP356C, ASP435C, ASP64C, ASP64D, ASP83C, ASP9C, GLN507C, GLN72C, GLU10C, GLU121C, GLU208D, GLU223C, GLU254D, GLU256D, GLU286C, GLU302C, GLU303C, GLU351C, GLU353C, GLU358C, GLU385D, GLU387D, GLU390D, GLU408C, GLU41D, GLU436C, GLU520C, GLU525C, GLU528C, GLU59D, GLU61C, GLU61D, GLU63D, GLU76C, GLY110C, GLY19D, GLY255D, GLY305C, GLY32D, GLY347C, GLY35D, GLY459D, GLY45D, GLY513C, GLY70C, HIS65C, ILE199D, ILE348C, ILE49D, ILE512C, ILE516C, ILE5C, ILE69C, LEU114C, LEU116C, LEU16C, LEU182D, LEU258D, LEU261D, LEU266D, LEU304C, LEU31D, LEU352C, LEU364C, LEU388D, LEU40D, LEU506C, LEU515C, LEU517C, LEU62D, LEU66C, LEU6C, LEU73C, LEU74C, LYS117C, LYS132C, LYS180D, LYS265D, LYS276D, LYS285C, LYS289C, LYS28D, LYS326D, LYS349C, LYS350C, LYS363C, LYS389D, LYS391D, LYS42D, LYS43D, LYS4C, LYS51D, LYS526C, LYS58D, LYS75C, LYS75D, LYS80C, MET210D, PHE306C, PHE44D, PHE8C, PRO113C, PRO155D, PRO201D, PRO207D, PRO33D, PRO47D, PRO527C, SER179D, SER181D, SER200D, SER301C, SER357C, SER46D, SER504C, SER511C, SER79C, THR209D, THR260D, THR298C, THR30D, THR325D, THR354C, THR355C, THR384D, THR386D, THR48D, THR50D, THR518C, THR519C, THR55D, THR81C, TYR198D, TYR202D, VAL107C, VAL124C, VAL128C, VAL204D, VAL23D, VAL253D, VAL262D, VAL263D, VAL27D, VAL299C, VAL29D, VAL38D, VAL39D, VAL522C, VAL523C, VAL56D, VAL60D, VAL77C, VAL7C, VAL84C
• C-I: ALA471I, ARG445C, ARG445I, ARG452C, ARG452I, GLN467C, GLN467I, GLN468I, GLU448I, GLU456C, GLU461C, GLU461I, GLY459C, GLY462C, GLY462I, ILE465C, ILE465I, ILE469I, SER463C, SER463I, TYR460C, VAL464C, VAL464I, VAL466I
• C-J: ALA108C, ALA108J, ALA109C, ALA109J, ALA111C, ALA111J, ALA11C, ALA437J, ARG101C, ARG13C, ARG14C, ARG14J, ARG444C, ARG444J, ASN106C, ASN106J, ASN112C, ASN112J, ASP435C, ASP435J, ASP9C, GLU102C, GLU102J, GLU10C, GLU10J, GLU17C, GLU433J, GLY103C, GLY110C, GLY110J, GLY434J, GLY439J, ILE429C, ILE442J, LEU104C, LEU116J, LEU432J, LYS105C, LYS105J, LYS441C, LYS441J, THR438C, THR438J, VAL100C, VAL107C, VAL107J
• C-Q: ARG267C, ASN264C, GLU237C, GLY28Q, LYS25Q, LYS27Q, VAL31Q
• C-R: ASP34R, GLU309C, LYS307C
• D-E: ALA108D, ALA111D, ALA115D, ALA12D, ALA22E, ALA24E, ALA257E, ALA259E, ALA26E, ALA343D, ALA382E, ALA383E, ALA3D, ALA458E, ALA483E, ALA505D, ALA509D, ALA510D, ALA514D, ALA521D, ALA524D, ALA57E, ALA71D, ALA71E, ALA78D, ARG118D, ARG13D, ARG267E, ARG344D, ARG34E, ARG361D, ARG367D, ARG36E, ARG394E, ARG503D, ASN106D, ASN112D, ASN153E, ASN21E, ASN25E, ASN264E, ASN346D, ASN37E, ASN457E, ASN508D, ASN68D, ASN68E, ASP154E, ASP282D, ASP327E, ASP356D, ASP435D, ASP64D, ASP64E, ASP83D, ASP9D, GLN507D, GLN72D, GLU10D, GLU121D, GLU208E, GLU211E, GLU254E, GLU256E, GLU286D, GLU302D, GLU303D, GLU328E, GLU351D, GLU353D, GLU385E, GLU387E, GLU390E, GLU41E, GLU520D, GLU525D, GLU59E, GLU61D, GLU61E, GLU63E, GLU76D, GLY110D, GLY19E, GLY255E, GLY305D, GLY32E, GLY347D, GLY35E, GLY45E, GLY513D, GLY70D, HIS65D, ILE199E, ILE348D, ILE49E, ILE512D, ILE516D, ILE5D, ILE69D, LEU114D, LEU116D, LEU16D, LEU182E, LEU258E, LEU261E, LEU266E, LEU304D, LEU364D, LEU388E, LEU40E, LEU506D, LEU515D, LEU517D, LEU62E, LEU66D, LEU6D, LEU73D, LEU74D, LYS117D, LYS132D, LYS180E, LYS265E, LYS276E, LYS285D, LYS289D, LYS28E, LYS326E, LYS349D, LYS350D, LYS389E, LYS391E, LYS42E, LYS43E, LYS4D, LYS51E, LYS526D, LYS58E, LYS75D, LYS75E, LYS80D, MET210E, PHE306D, PHE44E, PHE8D, PRO113D, PRO155E, PRO201E, PRO207E, PRO33E, PRO47E, SER179E, SER181E, SER200E, SER301D, SER46E, SER504D, SER511D, SER79D, THR209E, THR260E, THR298D, THR30E, THR325E, THR354D, THR355D, THR384E, THR386E, THR48E, THR50E, THR518D, THR519D, THR55E, THR81D, TYR198E, TYR202E, VAL107D, VAL124D, VAL128D, VAL204E, VAL23E, VAL253E, VAL262E, VAL263E, VAL27E, VAL299D, VAL29E, VAL38E, VAL39E, VAL522D, VAL523D, VAL56E, VAL60E, VAL77D, VAL7D, VAL84D
• D-J: ALA471J, ARG445D, ARG445J, ARG452D, ARG452J, GLN467D, GLN467J, GLN468D, GLN468J, GLU448J, GLU456D, GLU461D, GLU461J, GLY459D, GLY462D, GLY462J, ILE465D, ILE465J, ILE469J, LEU470J, PHE487J, SER463D, SER463J, TYR460D, VAL464D, VAL464J, VAL466J
• D-K: ALA108D, ALA108K, ALA109D, ALA109K, ALA111D, ALA111K, ALA11D, ALA437K, ARG101D, ARG13D, ARG14D, ARG14K, ARG444D, ARG444K, ASN106D, ASN106K, ASN112K, ASP435D, ASP435K, ASP9D, GLU102D, GLU102K, GLU10D, GLU10K, GLU17D, GLU433K, GLY103D, GLY110D, GLY110K, GLY434K, GLY439K, ILE429D, ILE442K, LEU104D, LEU116K, LEU432K, LYS105D, LYS105K, LYS441D, LYS441K, THR438D, THR438K, VAL107D, VAL107K
• D-R: ARG230D, ARG267D, ASN264D, GLU237D, GLU38R, GLY28R, LYS25R, LYS27R, VAL31R
• D-S: ASP34S, GLU309D, GLY305D, LYS307D
• E-F: ALA108E, ALA111E, ALA115E, ALA12E, ALA22F, ALA24F, ALA259F, ALA26F, ALA292E, ALA293E, ALA343E, ALA382F, ALA383F, ALA3E, ALA458F, ALA483F, ALA509E, ALA510E, ALA514E, ALA521E, ALA524E, ALA57F, ALA71E, ALA71F, ALA78E, ARG118E, ARG13E, ARG267F, ARG344E, ARG34F, ARG367E, ARG36F, ARG394F, ARG503E, ASN106E, ASN112E, ASN153F, ASN206F, ASN21F, ASN25F, ASN264F, ASN346E, ASN37F, ASN457F, ASN508E, ASN68E, ASN68F, ASP154F, ASP327F, ASP340E, ASP356E, ASP435E, ASP64E, ASP64F, ASP83E, ASP9E, GLN507E, GLN72E, GLU10E, GLU121E, GLU208F, GLU211F, GLU223E, GLU256F, GLU286E, GLU302E, GLU303E, GLU339E, GLU342E, GLU351E, GLU353E, GLU385F, GLU387F, GLU390F, GLU41F, GLU520E, GLU525E, GLU528E, GLU59F, GLU61E, GLU61F, GLU63F, GLU76E, GLY110E, GLY19F, GLY255F, GLY297E, GLY305E, GLY32F, GLY347E, GLY35F, GLY45F, GLY513E, GLY70E, HIS65E, ILE341E, ILE345E, ILE348E, ILE49F, ILE512E, ILE516E, ILE5E, ILE69E, LEU114E, LEU116E, LEU16E, LEU182F, LEU258F, LEU266F, LEU304E, LEU352E, LEU364E, LEU388F, LEU40F, LEU506E, LEU515E, LEU517E, LEU62F, LEU66E, LEU6E, LEU73E, LEU74E, LYS117E, LYS132E, LYS180F, LYS285E, LYS289E, LYS28F, LYS326F, LYS338E, LYS349E, LYS350E, LYS389F, LYS391F, LYS42F, LYS43F, LYS4E, LYS51F, LYS526E, LYS530F, LYS58F, LYS75E, LYS75F, LYS80E, MET210F, MET315E, PHE306E, PHE44F, PHE8E, PRO113E, PRO155F, PRO201F, PRO207F, PRO33F, PRO47F, SER179F, SER181F, SER200F, SER301E, SER46F, SER504E, SER511E, SER79E, THR205F, THR209F, THR260F, THR298E, THR30F, THR312E, THR325F, THR354E, THR355E, THR384F, THR386F, THR48F, THR50F, THR518E, THR519E, THR55F, THR81E, TYR198F, TYR202F, VAL107E, VAL124E, VAL128E, VAL204F, VAL23F, VAL262F, VAL263F, VAL27F, VAL299E, VAL29F, VAL38F, VAL39F, VAL522E, VAL523E, VAL56F, VAL60F, VAL77E, VAL7E, VAL84E
• E-K: ALA471K, ARG445E, ARG452E, ARG452K, GLN467E, GLN467K, GLN468K, GLU456E, GLU461E, GLU461K, GLY459E, GLY462E, GLY462K, ILE465E, ILE465K, ILE469K, SER463E, SER463K, TYR460E, VAL464E, VAL464K, VAL466K
• E-L: ALA108E, ALA108L, ALA109E, ALA109L, ALA111E, ALA111L, ALA11E, ALA437L, ARG101E, ARG13E, ARG14E, ARG14L, ARG18E, ARG444E, ARG444L, ASN106E, ASN106L, ASN112L, ASP435E, ASP435L, ASP9E, GLU102E, GLU102L, GLU10E, GLU10L, GLU17E, GLU433L, GLY103E, GLY110E, GLY110L, GLY434L, GLY439L, ILE429E, ILE442L, LEU104E, LEU104L, LEU116L, LYS105E, LYS105L, LYS441E, LYS441L, THR438E, THR438L, VAL100E, VAL107E, VAL107L
• E-S: ARG267E, ASN264E, GLU237E, LYS25S, LYS27S, VAL31S
• E-T: ASP34T, GLU309E, LYS307E
• F-G: ALA108F, ALA111F, ALA115F, ALA12F, ALA22G, ALA24G, ALA257G, ALA259G, ALA26G, ALA343F, ALA360F, ALA382G, ALA383G, ALA3F, ALA458G, ALA483G, ALA505F, ALA509F, ALA510F, ALA514F, ALA521F, ALA524F, ALA57G, ALA71F, ALA71G, ALA78F, ARG118F, ARG13F, ARG283F, ARG344F, ARG34G, ARG367F, ARG36G, ARG379G, ARG394G, ARG503F, ASN106F, ASN112F, ASN153G, ASN21G, ASN25G, ASN264G, ASN346F, ASN37G, ASN457G, ASN508F, ASN68F, ASN68G, ASP154G, ASP282F, ASP327G, ASP356F, ASP435F, ASP64F, ASP64G, ASP83F, ASP9F, GLN507F, GLN72F, GLU10F, GLU121F, GLU156G, GLU208G, GLU223F, GLU254G, GLU256G, GLU286F, GLU302F, GLU303F, GLU328G, GLU351F, GLU353F, GLU358F, GLU385G, GLU387G, GLU390G, GLU41G, GLU436F, GLU520F, GLU525F, GLU528F, GLU59G, GLU61F, GLU61G, GLU63G, GLU76F, GLY110F, GLY19G, GLY255G, GLY305F, GLY32G, GLY347F, GLY35G, GLY459G, GLY45G, GLY513F, GLY70F, HIS65F, ILE199G, ILE348F, ILE49G, ILE512F, ILE516F, ILE5F, ILE69F, LEU114F, LEU116F, LEU16F, LEU182G, LEU258G, LEU261G, LEU266G, LEU304F, LEU31G, LEU352F, LEU364F, LEU388G, LEU40G, LEU506F, LEU515F, LEU517F, LEU62G, LEU66F, LEU6F, LEU73F, LEU74F, LYS117F, LYS132F, LYS180G, LYS265G, LYS276G, LYS285F, LYS289F, LYS28G, LYS326G, LYS349F, LYS350F, LYS363F, LYS389G, LYS391G, LYS42G, LYS43G, LYS4F, LYS51G, LYS526F, LYS529F, LYS58G, LYS75F, LYS75G, LYS80F, MET210G, PHE306F, PHE44G, PHE8F, PRO113F, PRO155G, PRO201G, PRO207G, PRO33G, PRO47G, PRO527F, SER179G, SER181G, SER200G, SER301F, SER357F, SER46G, SER504F, SER511F, SER79F, THR209G, THR260G, THR298F, THR30G, THR325G, THR354F, THR355F, THR384G, THR386G, THR48G, THR50G, THR518F, THR519F, THR55G, THR81F, TYR198G, TYR202G, VAL107F, VAL124F, VAL128F, VAL23G, VAL253G, VAL262G, VAL263G, VAL27G, VAL299F, VAL29G, VAL38G, VAL39G, VAL522F, VAL523F, VAL56G, VAL60G, VAL77F, VAL7F, VAL84F
• F-L: ALA471L, ARG445F, ARG445L, ARG452F, ARG452L, GLN467F, GLN467L, GLN468L, GLU448L, GLU456F, GLU461F, GLU461L, GLY459F, GLY462F, GLY462L, ILE465F, ILE465L, ILE469L, SER463F, SER463L, TYR460F, VAL464F, VAL464L, VAL466L
• F-M: ALA108F, ALA108M, ALA109F, ALA109M, ALA111F, ALA111M, ALA11F, ARG101F, ARG13F, ARG14F, ARG14M, ASN106F, ASN106M, ASN112M, ASP435M, ASP9F, GLU102F, GLU102M, GLU10F, GLU10M, GLU17F, GLU433M, GLY103F, GLY110F, GLY110M, LEU104F, LEU104M, LEU116M, LYS105F, LYS105M, LYS441F, VAL100F, VAL107F, VAL107M
• F-T: ARG267F, ASN264F, GLU237F, GLY28T, LYS25T, LYS27T, VAL31T
• F-U: ASP34U, GLU309F, LYS307F
• G-M: GLU461G, GLU461M
• G-N: ASP435N, ASP9G, GLU10G, GLU433N, LYS105G, LYS105N, LYS441G
• G-O: ASN310G, ASP34O, GLU309G, LYS307G
• G-U: ARG230G, ARG267G, ASN264G, GLU237G, GLU38U, LYS25U, LYS27U, VAL31U
• H-I: ALA115I, ALA12I, ALA22H, ALA240H, ALA24H, ALA257I, ALA259I, ALA26H, ALA360I, ALA382H, ALA383H, ALA3I, ALA455H, ALA458H, ALA514I, ALA521I, ALA524I, ALA57H, ALA71H, ALA71I, ARG118I, ARG13I, ARG18H, ARG230I, ARG267H, ARG283I, ARG284I, ARG34H, ARG36H, ASN112I, ASN21H, ASN228I, ASN25H, ASN264H, ASN37H, ASN457H, ASN68H, ASN68I, ASP282I, ASP64H, ASP9I, GLN241H, GLN453H, GLN72I, GLU183H, GLU231I, GLU254I, GLU256I, GLU302I, GLU303I, GLU309I, GLU385H, GLU387H, GLU41H, GLU456H, GLU520I, GLU525I, GLU59H, GLU61H, GLU63H, GLU76I, GLY19H, GLY243H, GLY255I, GLY268H, GLY279I, GLY281I, GLY35H, GLY459H, GLY45H, GLY485H, GLY70I, HIS65I, ILE49H, ILE516I, ILE5I, ILE69I, LEU114I, LEU16I, LEU182H, LEU258I, LEU266H, LEU270H, LEU364I, LEU388H, LEU40H, LEU515I, LEU517I, LEU62H, LEU66I, LEU6I, LEU73I, LEU74I, LYS117I, LYS180H, LYS196I, LYS224I, LYS225I, LYS244H, LYS265H, LYS276I, LYS28H, LYS307I, LYS326I, LYS363I, LYS389H, LYS42H, LYS43H, LYS4I, LYS51H, LYS526I, LYS58H, LYS75H, LYS75I, PHE280I, PHE44H, PHE8I, PRO113I, PRO245H, PRO47H, PRO527I, SER179H, SER181H, SER227I, SER271H, SER357I, SER46H, SER511I, THR205H, THR242H, THR269H, THR30H, THR384H, THR386H, THR48H, THR50H, THR518I, THR519I, THR55H, TYR359I, TYR460H, VAL107I, VAL213H, VAL226I, VAL229I, VAL23H, VAL263H, VAL27H, VAL29H, VAL38H, VAL39H, VAL522I, VAL523I, VAL56H, VAL60H, VAL77I, VAL7I
• H-N: ALA3H, ALA521H, ARG267N, ARG284H, ARG36N, ASP282H, GLU183N, GLU256H, GLU385N, GLU41N, GLU520H, GLU525H, GLU528H, GLU59N, GLU61N, GLU63N, HIS65H, LYS180N, LYS276H, LYS42N, LYS43N, LYS4H, LYS526H, VAL39N, VAL523H
• I-J: ALA115J, ALA12J, ALA22I, ALA240I, ALA24I, ALA257J, ALA26I, ALA360J, ALA382I, ALA383I, ALA3J, ALA455I, ALA458I, ALA514J, ALA521J, ALA524J, ALA57I, ALA71I, ALA71J, ARG118J, ARG13J, ARG18I, ARG230J, ARG267I, ARG283J, ARG284J, ARG34I, ARG36I, ASN112J, ASN206I, ASN21I, ASN228J, ASN25I, ASN264I, ASN37I, ASN457I, ASN68I, ASN68J, ASP252J, ASP282J, ASP356J, ASP64I, ASP9J, GLN241I, GLN453I, GLN72I, GLN72J, GLU183I, GLU231J, GLU251J, GLU254J, GLU256J, GLU302J, GLU303J, GLU309J, GLU385I, GLU387I, GLU41I, GLU456I, GLU520J, GLU525J, GLU59I, GLU61I, GLU63I, GLU76J, GLY19I, GLY243I, GLY255J, GLY268I, GLY279J, GLY281J, GLY35I, GLY459I, GLY45I, GLY485I, GLY70J, HIS65J, ILE454I, ILE49I, ILE516J, ILE5J, ILE69J, LEU114J, LEU16J, LEU182I, LEU258J, LEU266I, LEU270I, LEU364J, LEU388I, LEU40I, LEU515J, LEU517J, LEU62I, LEU66J, LEU6J, LEU73J, LEU74J, LYS117J, LYS180I, LYS196J, LYS224J, LYS225J, LYS244I, LYS265I, LYS276J, LYS285J, LYS28I, LYS307J, LYS326J, LYS363J, LYS389I, LYS42I, LYS43I, LYS4J, LYS51I, LYS526J, LYS58I, LYS75I, LYS75J, PHE280J, PHE44I, PHE8J, PRO113J, PRO207I, PRO245I, PRO47I, PRO527J, SER179I, SER181I, SER227J, SER271I, SER357J, SER46I, SER511J, THR205I, THR242I, THR269I, THR30I, THR355J, THR384I, THR386I, THR48I, THR50I, THR518J, THR519J, THR55I, TYR359J, TYR460I, VAL107J, VAL213I, VAL226J, VAL229J, VAL23I, VAL263I, VAL27I, VAL29I, VAL38I, VAL39I, VAL522J, VAL523J, VAL56I, VAL60I, VAL77J, VAL7J
• J-K: ALA115K, ALA12K, ALA22J, ALA240J, ALA24J, ALA257K, ALA259K, ALA26J, ALA360K, ALA382J, ALA383J, ALA3K, ALA455J, ALA458J, ALA482J, ALA514K, ALA521K, ALA524K, ALA57J, ALA71J, ALA71K, ARG118K, ARG13K, ARG18J, ARG230K, ARG267J, ARG283K, ARG284K, ARG34J, ARG36J, ASN112K, ASN21J, ASN228K, ASN25J, ASN264J, ASN37J, ASN457J, ASN68J, ASN68K, ASP252K, ASP282K, ASP64J, ASP9K, GLN241J, GLN453J, GLN72K, GLU183J, GLU231K, GLU251K, GLU254K, GLU256K, GLU302K, GLU303K, GLU309K, GLU385J, GLU387J, GLU41J, GLU456J, GLU520K, GLU525K, GLU59J, GLU61J, GLU63J, GLU76K, GLY19J, GLY243J, GLY255K, GLY268J, GLY279K, GLY281K, GLY35J, GLY459J, GLY45J, GLY485J, GLY70K, HIS65K, ILE454J, ILE49J, ILE516K, ILE5K, ILE69K, LEU114K, LEU16K, LEU182J, LEU258K, LEU266J, LEU270J, LEU308K, LEU364K, LEU388J, LEU40J, LEU515K, LEU517K, LEU62J, LEU66K, LEU6K, LEU73K, LEU74K, LYS117K, LYS180J, LYS196K, LYS224K, LYS225K, LYS244J, LYS265J, LYS276K, LYS28J, LYS307K, LYS326K, LYS363K, LYS389J, LYS42J, LYS43J, LYS4K, LYS51J, LYS526K, LYS58J, LYS75J, PHE280K, PHE44J, PHE480J, PHE8K, PRO113K, PRO245J, PRO47J, PRO527K, SER179J, SER181J, SER227K, SER271J, SER357K, SER46J, SER511K, THR205J, THR242J, THR269J, THR30J, THR384J, THR386J, THR48J, THR50J, THR518K, THR519K, THR55J, TYR202K, TYR359K, TYR460J, VAL107K, VAL213J, VAL226K, VAL229K, VAL23J, VAL263J, VAL27J, VAL29J, VAL38J, VAL39J, VAL522K, VAL523K, VAL56J, VAL60J, VAL77K, VAL7K
• K-L: ALA115L, ALA12L, ALA22K, ALA240K, ALA24K, ALA257L, ALA26K, ALA360L, ALA382K, ALA383K, ALA3L, ALA455K, ALA458K, ALA482K, ALA514L, ALA521L, ALA524L, ALA57K, ALA71K, ALA71L, ARG118L, ARG13L, ARG18K, ARG230L, ARG267K, ARG283L, ARG284L, ARG34K, ARG36K, ASN112L, ASN206K, ASN21K, ASN228L, ASN25K, ASN264K, ASN37K, ASN457K, ASN68K, ASN68L, ASP282L, ASP356L, ASP64K, ASP9L, GLN241K, GLN453K, GLN72K, GLN72L, GLU183K, GLU231L, GLU254L, GLU256L, GLU302L, GLU303L, GLU309L, GLU385K, GLU387K, GLU41K, GLU456K, GLU520L, GLU525L, GLU528L, GLU59K, GLU61K, GLU63K, GLU76L, GLY19K, GLY243K, GLY255L, GLY268K, GLY279L, GLY281L, GLY35K, GLY459K, GLY45K, GLY485K, GLY70L, HIS65L, ILE454K, ILE49K, ILE512L, ILE516L, ILE5L, ILE69L, LEU114L, LEU16L, LEU182K, LEU258L, LEU266K, LEU270K, LEU308L, LEU364L, LEU388K, LEU40K, LEU515L, LEU517L, LEU62K, LEU66L, LEU6L, LEU73L, LEU74L, LYS117L, LYS180K, LYS196L, LYS224L, LYS225L, LYS244K, LYS265K, LYS276L, LYS28K, LYS307L, LYS326L, LYS363L, LYS389K, LYS42K, LYS43K, LYS4L, LYS51K, LYS526L, LYS58K, LYS75K, LYS75L, LYS80L, PHE280L, PHE44K, PHE480K, PHE8L, PRO113L, PRO207K, PRO245K, PRO47K, PRO527L, SER179K, SER181K, SER227L, SER271K, SER357L, SER46K, SER511L, THR205K, THR242K, THR269K, THR30K, THR355L, THR384K, THR386K, THR48K, THR50K, THR518L, THR519L, THR55K, TYR202L, TYR359L, TYR460K, VAL107L, VAL213K, VAL226L, VAL229L, VAL23K, VAL263K, VAL27K, VAL29K, VAL38K, VAL39K, VAL522L, VAL523L, VAL56K, VAL60K, VAL77L, VAL7L
• L-M: ALA115M, ALA12M, ALA22L, ALA24L, ALA26L, ALA383L, ALA3M, ALA455L, ALA458L, ALA482L, ALA521M, ALA57L, ALA71L, ALA71M, ARG118M, ARG13M, ARG18L, ARG267L, ARG284M, ARG34L, ARG36L, ASN112M, ASN21L, ASN228M, ASN25L, ASN37L, ASN457L, ASN68L, ASN68M, ASP216L, ASP252M, ASP282M, ASP64L, ASP64M, ASP9M, GLN241L, GLN72L, GLN72M, GLU183L, GLU215L, GLU231M, GLU251M, GLU256M, GLU302M, GLU385L, GLU41L, GLU456L, GLU520M, GLU525M, GLU59L, GLU61L, GLU61M, GLU63L, GLU67M, GLU76M, GLY19L, GLY268L, GLY35L, GLY459L, GLY45L, GLY485L, GLY70M, HIS65M, ILE454L, ILE49L, ILE5M, ILE69M, LEU114M, LEU16M, LEU40L, LEU62L, LEU66M, LEU6M, LEU73M, LEU74M, LYS117M, LYS180L, LYS196M, LYS224M, LYS225M, LYS244L, LYS276M, LYS28L, LYS42L, LYS43L, LYS4M, LYS51L, LYS526M, LYS58L, LYS75L, LYS75M, LYS80M, PHE44L, PHE480L, PHE8M, PRO113M, PRO47L, SER46L, THR384L, THR48L, THR518M, TYR460L, VAL107M, VAL23L, VAL27L, VAL29L, VAL38L, VAL39L, VAL523M, VAL56L, VAL60L, VAL77M, VAL7M
• M-N: ALA3N, ALA521N, ARG267M, ARG284N, ARG36M, ASN37M, ASP282N, GLU256N, GLU385M, GLU41M, GLU520N, GLU525N, GLU528N, GLU59M, GLU61M, GLU63M, GLY268M, HIS65N, LYS180M, LYS276N, LYS28M, LYS42M, LYS43M, LYS4N, LYS526N, SER227N, THR518N, VAL39M, VAL523N
• O-P: ARG14P, ARG52O, ARG59P, ARG93O, ASP68O, GLN100O, GLU55O, GLU55P, GLU63O, GLU81P, GLU85P, LEU11P, LEU96O, LYS27O, LYS9P, THR50P, VAL53P, VAL7P, VAL98O
• O-Q: GLU55O, GLU55Q
• O-T: GLU55O, GLU55T
• O-U: ARG14O, ARG93U, ASP68U, ASP83O, GLN100U, GLU22U, GLU23U, GLU55O, GLU55U, GLU81O, GLU85O, LEU11O, LEU96U, LYS27U, LYS9O, VAL7O, VAL98U
• P-Q: ARG14Q, ARG93P, ASP68P, ASP83Q, GLN100P, GLU22P, GLU23P, GLU55P, GLU55Q, GLU63P, GLU81Q, GLU85Q, GLY12Q, LEU95P, LYS27P, LYS9Q, VAL7Q, VAL98P
• P-R: GLU55P, GLU55R
• Q-R: ARG14R, ARG52Q, ARG93Q, ASP68Q, GLN100Q, GLU55Q, GLU55R, GLU63Q, GLU81R, LYS27Q, LYS9R, THR50R, VAL53R, VAL7R, VAL98Q
• Q-S: GLU55Q, GLU55S
• R-S: ARG14S, ARG93R, ASP68R, GLN100R, GLU55R, GLU55S, GLU63R, GLU81S, GLU85S, LYS27R, LYS9S, THR50S, VAL7S, VAL98R
• S-T: ARG14T, ASP68S, GLN100S, GLN58S, GLU22S, GLU55S, GLU55T, GLU63S, GLU81T, GLU85T, LEU95S, LYS27S, LYS9T, VAL7T, VAL98S
• S-U: GLU55S, GLU55U
• T-U: ARG14U, ARG52T, GLN100T, GLU55T, GLU55U, GLU81U, GLU85U, LEU11U, LEU95T, LEU96T, LYS27T, LYS9U, VAL53U, VAL7U, VAL98T