1WCE

crystal structure of the t13 ibdv viral particle reveals a missing link in icosahedral viruses evolution

• Total interactions analyzed: 78
• Total true interactions: 26
• Strongest Interaction:
  • Chains: D-G
  • Int. Res.: 35
  • Norm. En. per Res.: -0.1389
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	29.1129	29.1129	52	11	0	953	0	0	0
A-F	0.0	0.0	-15.7986	-15.7986	120	0	0	2248	0	0	0
A-G	0.0	0.0	-0.5539	-0.5539	27	0	0	202	0	0	0
A-H	0.0	0.0	-0.0167	-0.0167	5	0	0	15	0	0	0
A-J	0.0	0.0	-15.3677	-15.3677	123	0	0	2330	0	0	0
B-G	0.0	0.0	-14.7422	-14.7422	118	0	0	2247	0	0	0
B-H	0.0	0.0	-3.791	-3.791	36	17	0	676	0	0	0
B-J	0.0	0.0	-2.0569	-2.0569	18	0	0	298	0	0	0
B-K	0.0	0.0	-15.5188	-15.5188	123	0	0	2276	0	0	0
B-L	0.0	0.0	-0.0488	-0.0488	14	0	0	38	0	0	0
C-H	0.0	0.0	-15.5138	-15.5138	121	0	0	2274	0	0	0
C-L	0.0	0.0	-15.2667	-15.2667	123	0	0	2331	0	0	0
D-G	0.0	0.0	-4.8622	-4.8622	35	21	0	542	0	0	0
D-I	0.0	0.0	-14.6425	-14.6425	121	0	0	2244	0	0	0
D-K	0.0	0.0	-0.0525	-0.0525	10	0	0	38	0	0	0
D-M	0.0	0.0	-16.2717	-16.2717	122	0	0	2287	0	0	0
E-K	0.0	0.0	-0.0326	-0.0326	5	0	0	25	0	0	0
E-M	0.0	0.0	73.4027	73.4027	48	8	0	872	0	0	0
F-J	0.0	0.0	-15.5628	-15.5628	122	0	0	2308	0	0	0
G-J	0.0	0.0	1.2528	1.2528	49	6	0	742	0	0	0
G-K	0.0	0.0	-16.2942	-16.2942	121	0	0	2326	0	0	0
H-L	0.0	0.0	-16.0335	-16.0335	122	2	0	2308	0	0	0
I-M	0.0	0.0	-16.2616	-16.2616	120	2	0	2320	0	0	0
K-L	0.0	0.0	0.3415	0.3415	44	4	0	945	0	0	0
K-M	0.0	0.0	13.6544	13.6544	48	22	0	1006	0	0	0
L-M	0.0	0.0	-0.0026	-0.0026	4	0	0	8	0	0	0

Interface residues

• A-B: ALA119B, ALA147B, ALA358B, ALA366A, ALA89A, ARG356B, ASN121B, ASN125B, ASN142B, ASN157B, ASN46A, ASN91A, ASP138B, GLN90A, GLU355B, GLU41A, GLY115A, GLY122B, GLY143B, GLY156B, GLY161A, GLY360A, GLY53B, LEU113A, LEU120B, LEU144B, LEU159B, LEU47A, LEU87A, MET145B, PRO114A, SER110A, SER111A, SER146B, SER361A, SER361B, SER43A, THR112A, THR123B, THR359B, THR364A, THR42A, THR44A, THR48A, THR52B, THR88A, TYR141B, TYR354B, TYR45A, VAL357B, VAL362A, VAL363A
• A-F: ALA147A, ALA149A, ALA186F, ALA195F, ALA210A, ALA211A, ALA232A, ALA275F, ALA277F, ALA278F, ALA334A, ALA380F, ARG179F, ARG202A, ARG202F, ARG204A, ARG389F, ARG405A, ASN150A, ASN233A, ASN279F, ASN288A, ASN293A, ASN293F, ASN341A, ASN376F, ASN382F, ASN396A, ASP174A, ASP174F, ASP190F, ASP198F, ASP201A, ASP201F, ASP212A, ASP213A, ASP287A, ASP30A, ASP31A, ASP31F, ASP391F, CYS197F, GLN130A, GLU135A, GLU245A, GLU34F, GLU378F, GLU404A, GLY131A, GLY176F, GLY188F, GLY243A, GLY244A, GLY339A, GLY388F, HIS338F, ILE184F, ILE187F, ILE208A, ILE234A, ILE296F, ILE374F, ILE401A, LEU136A, LEU175A, LEU189F, LEU229A, LEU289A, LEU294F, LEU333A, LEU33F, LEU383F, LEU400A, LEU402A, LYS192F, LYS35F, LYS381F, LYS399A, MET193F, PHE129A, PHE230A, PHE292A, PHE390F, PRO170A, PRO185F, PRO191F, PRO203A, PRO291A, PRO297F, PRO375F, PRO377F, PRO392F, SER146A, SER172A, SER199F, SER200F, SER231A, SER239F, SER332A, SER403A, THR137A, THR148A, THR171A, THR196F, THR207A, THR209A, THR228A, THR286A, THR298F, THR32F, THR385F, TYR173A, TYR206A, TYR214A, TYR342A, TYR387F, VAL194F, VAL205A, VAL295F, VAL384F
• A-G: ALA94A, ALA94G, ASN382A, ASN382G, ASP190A, ASP190G, GLN90A, GLN90G, GLU378A, GLU378G, GLY188A, GLY188G, ILE187A, ILE187G, LEU189A, LEU189G, LEU379A, LEU379G, LEU383A, LEU383G, LYS192A, LYS381A, LYS381G, PRO191A, PRO191G, SER95A, SER95G
• A-H: GLY115A, GLY116A, GLY116H, VAL117A, VAL117H
• A-J: ALA147J, ALA149J, ALA186A, ALA195A, ALA210J, ALA211J, ALA232J, ALA275A, ALA277A, ALA278A, ALA334J, ALA380A, ARG202A, ARG202J, ARG204J, ARG389A, ARG405J, ASN150J, ASN233J, ASN279A, ASN288J, ASN293A, ASN293J, ASN341J, ASN376A, ASN382A, ASN396J, ASP174A, ASP174J, ASP190A, ASP198A, ASP201A, ASP201J, ASP212J, ASP213J, ASP287J, ASP30J, ASP31A, ASP31J, ASP391A, CYS197A, GLN130J, GLU135J, GLU245J, GLU34A, GLU378A, GLU386A, GLU404J, GLY131J, GLY176A, GLY188A, GLY243J, GLY244J, GLY339J, GLY388A, HIS338A, ILE184A, ILE187A, ILE208J, ILE234J, ILE296A, ILE374A, ILE401J, LEU136J, LEU175J, LEU189A, LEU229J, LEU289J, LEU294A, LEU333J, LEU33A, LEU383A, LEU400J, LEU402J, LYS192A, LYS35A, LYS381A, LYS399J, MET193A, PHE230J, PHE292A, PHE292J, PHE390A, PRO170J, PRO185A, PRO191A, PRO203J, PRO291J, PRO297A, PRO343J, PRO377A, PRO392A, SER146J, SER172J, SER199A, SER200A, SER231J, SER239A, SER241A, SER332J, SER403J, THR137J, THR148J, THR171J, THR196A, THR207J, THR209J, THR228J, THR286J, THR298A, THR32A, THR385A, TYR173J, TYR206J, TYR214J, TYR342J, TYR387A, VAL194A, VAL205J, VAL247J, VAL276A, VAL295A, VAL384A
• B-G: ALA147B, ALA149B, ALA186G, ALA195G, ALA210B, ALA211B, ALA232B, ALA277G, ALA278G, ALA334B, ALA380G, ARG202B, ARG202G, ARG204B, ARG389G, ARG405B, ASN150B, ASN233B, ASN279G, ASN288B, ASN293B, ASN293G, ASN341B, ASN376G, ASN382G, ASN396B, ASP174B, ASP174G, ASP190G, ASP198G, ASP201B, ASP201G, ASP212B, ASP213B, ASP287B, ASP30B, ASP31B, ASP31G, ASP391G, ASP406B, CYS197G, GLN130B, GLU135B, GLU245B, GLU34G, GLU378G, GLU386G, GLU404B, GLY131B, GLY176G, GLY188G, GLY243B, GLY244B, GLY388G, HIS338G, ILE151B, ILE184G, ILE187G, ILE208B, ILE234B, ILE296G, ILE374G, ILE401B, LEU136B, LEU175B, LEU189G, LEU229B, LEU289B, LEU294G, LEU333B, LEU33G, LEU383G, LEU400B, LEU402B, LYS192G, LYS35G, LYS381G, LYS399B, MET193G, PHE230B, PHE292B, PHE390G, PRO170B, PRO185G, PRO191G, PRO203B, PRO291B, PRO297G, PRO377G, PRO392G, SER146B, SER172B, SER199G, SER200G, SER231B, SER239G, SER241G, SER332B, SER403B, THR137B, THR148B, THR171B, THR196G, THR207B, THR209B, THR228B, THR286B, THR32G, THR385G, TYR173B, TYR206B, TYR214B, TYR342B, TYR387G, VAL194G, VAL205B, VAL295G, VAL384G
• B-H: ALA119H, ALA366B, ALA89B, ARG356H, ASN121H, ASN142H, ASN157H, ASN46B, ASP138H, GLN90B, GLU355H, GLU41B, GLY115B, GLY116B, GLY122H, GLY143H, GLY161H, LEU113B, LEU120H, LEU144H, MET145H, PRO114B, SER110B, SER111B, SER146H, SER43B, THR112B, THR364B, THR42B, THR44B, THR88B, TYR118H, TYR141H, TYR45B, VAL357H, VAL362B
• B-J: ASP323B, ASP323J, GLN219B, GLN219J, GLN324B, GLN324J, GLY322B, GLY322J, MET325B, MET325J, PHE216B, PHE216J, SER217B, SER217J, SER218B, SER218J, SER326B, SER326J
• B-K: ALA147K, ALA149K, ALA186B, ALA195B, ALA210K, ALA211K, ALA232K, ALA275B, ALA277B, ALA278B, ALA334K, ALA380B, ARG179B, ARG202B, ARG202K, ARG204K, ARG389B, ARG405K, ASN150K, ASN233K, ASN279B, ASN288K, ASN293B, ASN293K, ASN341K, ASN376B, ASN382B, ASN396K, ASP174B, ASP174K, ASP190B, ASP198B, ASP201B, ASP201K, ASP212K, ASP213K, ASP287K, ASP30K, ASP31B, ASP31K, ASP391B, CYS197B, GLN130K, GLU135K, GLU245K, GLU34B, GLU378B, GLU386B, GLU404K, GLY131K, GLY176B, GLY188B, GLY243K, GLY244K, GLY388B, HIS338B, ILE184B, ILE187B, ILE208K, ILE227K, ILE234K, ILE296B, ILE374B, LEU136K, LEU175K, LEU189B, LEU229K, LEU289K, LEU294B, LEU333K, LEU33B, LEU383B, LEU400K, LEU402K, LYS192B, LYS35B, LYS381B, LYS399K, MET193B, PHE129K, PHE230K, PHE292B, PHE292K, PHE390B, PRO170K, PRO185B, PRO191B, PRO203K, PRO291B, PRO291K, PRO297B, PRO375B, PRO377B, PRO392B, SER146K, SER172K, SER199B, SER200B, SER231K, SER239B, SER241B, SER332K, SER403K, THR137K, THR148K, THR171K, THR196B, THR207K, THR209K, THR228K, THR286K, THR32B, THR385B, TYR173K, TYR206K, TYR214K, TYR387B, VAL194B, VAL205K, VAL247K, VAL276B, VAL295B, VAL384B
• B-L: ARG39B, ARG39L, ASN382B, ASN382L, GLN90L, GLU378B, GLU378L, LEU379B, LEU379L, LEU383B, LEU383L, LYS381B, SER95B, SER95L
• C-H: ALA147C, ALA149C, ALA186H, ALA195H, ALA210C, ALA211C, ALA232C, ALA277H, ALA278H, ALA334C, ALA380H, ARG179H, ARG202C, ARG202H, ARG204C, ARG389H, ARG405C, ASN150C, ASN233C, ASN279H, ASN288C, ASN293C, ASN293H, ASN341C, ASN376H, ASN382H, ASN396C, ASP174C, ASP174H, ASP190H, ASP198H, ASP201C, ASP201H, ASP212C, ASP213C, ASP287C, ASP30C, ASP31C, ASP31H, ASP391H, CYS197H, GLN130C, GLU135C, GLU245C, GLU34H, GLU378H, GLU386H, GLU404C, GLY131C, GLY176H, GLY188H, GLY243C, GLY244C, GLY339C, GLY388H, HIS338H, ILE184H, ILE187H, ILE208C, ILE234C, ILE296H, ILE374H, ILE401C, LEU136C, LEU175C, LEU189H, LEU229C, LEU289C, LEU294H, LEU333C, LEU33H, LEU383H, LEU400C, LEU402C, LYS192H, LYS35H, LYS381H, LYS399C, MET193H, PHE129C, PHE230C, PHE292C, PHE390H, PRO170C, PRO185H, PRO191H, PRO203C, PRO291C, PRO291H, PRO297H, PRO375H, PRO377H, PRO392H, SER146C, SER172C, SER199H, SER200H, SER231C, SER239H, SER332C, SER403C, THR137C, THR148C, THR171C, THR196H, THR207C, THR209C, THR228C, THR286C, THR298H, THR32H, THR385H, TYR173C, TYR206C, TYR214C, TYR342C, TYR387H, VAL194H, VAL205C, VAL295H, VAL384H
• C-L: ALA147L, ALA149L, ALA186C, ALA195C, ALA210L, ALA211L, ALA232L, ALA275C, ALA277C, ALA278C, ALA334L, ALA380C, ARG202C, ARG202L, ARG204L, ARG389C, ARG405L, ASN150L, ASN233L, ASN279C, ASN288L, ASN293C, ASN293L, ASN341L, ASN376C, ASN382C, ASN396L, ASP174C, ASP174L, ASP190C, ASP198C, ASP201C, ASP201L, ASP212L, ASP213L, ASP287L, ASP30L, ASP31C, ASP31L, ASP391C, CYS197C, GLN130L, GLU135L, GLU245L, GLU34C, GLU378C, GLU386C, GLU404L, GLY131L, GLY176C, GLY188C, GLY243L, GLY244L, GLY388C, HIS338C, ILE151L, ILE184C, ILE187C, ILE208L, ILE234L, ILE296C, ILE374C, ILE401L, LEU136L, LEU175L, LEU189C, LEU229L, LEU289L, LEU294C, LEU333L, LEU33C, LEU383C, LEU400L, LEU402L, LYS192C, LYS35C, LYS381C, LYS399L, MET193C, PHE230L, PHE292C, PHE292L, PHE390C, PRO170L, PRO185C, PRO191C, PRO203L, PRO291L, PRO297C, PRO343L, PRO377C, PRO392C, SER146L, SER172L, SER199C, SER200C, SER231L, SER239C, SER241C, SER332L, SER403L, THR137L, THR148L, THR171L, THR196C, THR207L, THR209L, THR228L, THR286L, THR298C, THR32C, THR385C, TYR173L, TYR206L, TYR214L, TYR342L, TYR387C, VAL194C, VAL205L, VAL247L, VAL276C, VAL295C, VAL384C
• D-G: ALA119G, ALA147G, ALA366D, ALA89D, ARG356G, ASN121G, ASN142G, ASN157G, ASN46D, GLN90D, GLU355G, GLY115D, GLY116D, GLY122G, GLY143G, GLY156G, GLY161G, LEU113D, LEU120G, LEU144G, LEU159G, MET145G, PRO114D, SER111D, SER146G, SER361D, SER43D, THR112D, THR123G, THR42D, THR44D, THR48D, TYR118G, TYR45D, VAL362D
• D-I: ALA147D, ALA149D, ALA186I, ALA195I, ALA210D, ALA211D, ALA232D, ALA275I, ALA277I, ALA278I, ALA334D, ALA380I, ARG179I, ARG202D, ARG202I, ARG204D, ARG389I, ARG405D, ASN150D, ASN233D, ASN279I, ASN288D, ASN293I, ASN341D, ASN376I, ASN382I, ASN396D, ASP174D, ASP174I, ASP190I, ASP198I, ASP201D, ASP201I, ASP212D, ASP213D, ASP287D, ASP30D, ASP31D, ASP31I, ASP391I, CYS197I, GLN130D, GLU135D, GLU245D, GLU34I, GLU378I, GLU386I, GLU404D, GLY131D, GLY176I, GLY188I, GLY243D, GLY244D, GLY388I, HIS338I, ILE184I, ILE187I, ILE208D, ILE234D, ILE296I, ILE374I, LEU136D, LEU175D, LEU189I, LEU229D, LEU289D, LEU294I, LEU333D, LEU33I, LEU383I, LEU400D, LEU402D, LYS192I, LYS35I, LYS381I, LYS399D, MET193I, PHE129D, PHE230D, PHE292D, PHE292I, PHE390I, PRO170D, PRO185I, PRO191I, PRO203D, PRO291D, PRO291I, PRO297I, PRO375I, PRO377I, PRO392I, SER146D, SER172D, SER199I, SER200I, SER231D, SER239I, SER241I, SER332D, SER403D, THR137D, THR148D, THR171D, THR196I, THR207D, THR209D, THR228D, THR286D, THR32I, THR385I, TYR173D, TYR206D, TYR214D, TYR387I, VAL194I, VAL205D, VAL247D, VAL276I, VAL295I, VAL384I
• D-K: ARG39K, ASN382D, ASN382K, GLU378D, LEU379D, LEU379K, LEU383D, LEU383K, SER95D, SER95K
• D-M: ALA147M, ALA149M, ALA186D, ALA195D, ALA210M, ALA211M, ALA232M, ALA275D, ALA277D, ALA278D, ALA334M, ALA380D, ARG179D, ARG202D, ARG202M, ARG204M, ARG389D, ARG405M, ASN150M, ASN233M, ASN279D, ASN288M, ASN293D, ASN293M, ASN341M, ASN376D, ASN382D, ASN396M, ASP174D, ASP174M, ASP190D, ASP198D, ASP201D, ASP201M, ASP212M, ASP213M, ASP287M, ASP30M, ASP31D, ASP31M, ASP391D, CYS197D, GLN130M, GLU135M, GLU245M, GLU34D, GLU378D, GLU386D, GLU404M, GLY131M, GLY176D, GLY188D, GLY243M, GLY244M, GLY339M, GLY388D, HIS338D, ILE184D, ILE187D, ILE208M, ILE234M, ILE296D, ILE374D, ILE401M, LEU136M, LEU175M, LEU189D, LEU229M, LEU289M, LEU294D, LEU333M, LEU33D, LEU383D, LEU400M, LEU402M, LYS192D, LYS35D, LYS381D, LYS399M, MET193D, PHE129M, PHE230M, PHE292D, PHE292M, PHE390D, PRO170M, PRO185D, PRO191D, PRO203M, PRO291M, PRO297D, PRO375D, PRO377D, PRO392D, SER146M, SER172M, SER199D, SER200D, SER231M, SER239D, SER332M, SER403M, THR137M, THR148M, THR171M, THR196D, THR207M, THR209M, THR228M, THR286M, THR298D, THR32D, THR385D, TYR173M, TYR206M, TYR214M, TYR342M, TYR387D, VAL194D, VAL205M, VAL295D, VAL384D
• E-K: GLY115K, GLY116E, GLY116K, TYR118E, VAL117E
• E-M: ALA119E, ALA147E, ALA358E, ALA366M, ALA89M, ARG356E, ASN121E, ASN142E, ASN157E, ASN46M, ASP138E, GLN90M, GLU355E, GLU41M, GLY115E, GLY115M, GLY116E, GLY116M, GLY122E, GLY143E, GLY156E, LEU113E, LEU113M, LEU120E, LEU144E, LEU47M, MET145E, PRO114E, PRO114M, SER110M, SER111M, SER146E, SER361M, SER43M, THR112M, THR359E, THR42M, THR44M, THR48M, THR88M, TYR118E, TYR118M, TYR141E, TYR45M, VAL117E, VAL117M, VAL357E, VAL362M
• F-J: ALA147F, ALA149F, ALA186J, ALA195J, ALA210F, ALA211F, ALA232F, ALA275J, ALA277J, ALA278J, ALA334F, ALA380J, ARG179J, ARG202F, ARG202J, ARG204F, ARG389J, ARG405F, ASN150F, ASN233F, ASN279J, ASN288F, ASN293F, ASN293J, ASN341F, ASN376J, ASN382J, ASN396F, ASP174F, ASP174J, ASP190J, ASP198J, ASP201F, ASP201J, ASP212F, ASP213F, ASP287F, ASP30F, ASP31F, ASP31J, ASP391J, CYS197J, GLN130F, GLU135F, GLU245F, GLU34J, GLU378J, GLU386J, GLU404F, GLY131F, GLY176J, GLY188J, GLY243F, GLY244F, GLY388J, HIS338J, ILE184J, ILE187J, ILE208F, ILE234F, ILE296J, ILE374J, LEU136F, LEU175F, LEU189J, LEU229F, LEU289F, LEU294J, LEU333F, LEU33J, LEU383J, LEU400F, LEU402F, LYS192J, LYS35J, LYS381J, LYS399F, MET193J, PHE129F, PHE230F, PHE292F, PHE292J, PHE390J, PRO170F, PRO185J, PRO191J, PRO203F, PRO291F, PRO291J, PRO297J, PRO375J, PRO377J, PRO392J, SER146F, SER172F, SER199J, SER200J, SER231F, SER239J, SER241J, SER307F, SER332F, SER403F, THR137F, THR148F, THR171F, THR196J, THR207F, THR209F, THR228F, THR286F, THR32J, THR385J, TYR173F, TYR206F, TYR214F, TYR387J, VAL194J, VAL205F, VAL247F, VAL295J, VAL384J
• G-J: ALA119J, ALA147J, ALA358J, ALA366G, ALA89G, ARG356J, ASN121J, ASN125J, ASN142J, ASN157J, ASN46G, ASN91G, ASP138J, GLN90G, GLU355J, GLU41G, GLY115G, GLY122J, GLY143J, GLY360G, GLY53J, LEU113G, LEU120J, LEU144J, LEU47G, LEU87G, MET145J, PRO114G, SER110G, SER111G, SER146J, SER361G, SER43G, SER54J, THR112G, THR123J, THR137J, THR359J, THR364G, THR42G, THR44G, THR48G, THR52J, THR88G, TYR141J, TYR45G, VAL357J, VAL362G, VAL363G
• G-K: ALA147G, ALA149G, ALA186K, ALA195K, ALA210G, ALA211G, ALA232G, ALA277K, ALA278K, ALA334G, ALA380K, ARG179K, ARG202G, ARG202K, ARG204G, ARG389K, ARG405G, ASN150G, ASN233G, ASN279K, ASN288G, ASN293G, ASN293K, ASN341G, ASN376K, ASN382K, ASN396G, ASP174G, ASP174K, ASP190K, ASP198K, ASP201G, ASP201K, ASP212G, ASP287G, ASP30G, ASP31G, ASP31K, ASP391K, CYS197K, GLN130G, GLU135G, GLU245G, GLU34K, GLU378K, GLU386K, GLU404G, GLY131G, GLY176K, GLY188K, GLY243G, GLY244G, GLY331G, GLY339G, GLY388K, HIS338K, ILE184K, ILE187K, ILE208G, ILE234G, ILE296K, ILE374K, ILE401G, LEU136G, LEU175G, LEU189K, LEU229G, LEU289G, LEU294K, LEU333G, LEU33K, LEU383K, LEU400G, LEU402G, LYS192K, LYS35K, LYS381K, LYS399G, MET193K, PHE129G, PHE230G, PHE292G, PHE292K, PHE390K, PRO170G, PRO185K, PRO191K, PRO203G, PRO291G, PRO297K, PRO375K, PRO377K, PRO392K, SER146G, SER172G, SER199K, SER200K, SER231G, SER239K, SER332G, SER403G, THR137G, THR148G, THR171G, THR196K, THR207G, THR209G, THR228G, THR286G, THR298K, THR32K, THR385K, TYR173G, TYR206G, TYR214G, TYR342G, TYR387K, VAL194K, VAL205G, VAL295K, VAL384K
• H-L: ALA147H, ALA149H, ALA186L, ALA195L, ALA210H, ALA211H, ALA232H, ALA275L, ALA277L, ALA278L, ALA334H, ALA380L, ARG179L, ARG202H, ARG202L, ARG204H, ARG389L, ARG405H, ASN150H, ASN233H, ASN279L, ASN288H, ASN293H, ASN293L, ASN341H, ASN376L, ASN382L, ASN396H, ASP174H, ASP174L, ASP190L, ASP198L, ASP201H, ASP201L, ASP212H, ASP213H, ASP287H, ASP30H, ASP31H, ASP31L, ASP391L, CYS197L, GLN130H, GLU135H, GLU245H, GLU34L, GLU378L, GLU386L, GLU404H, GLY131H, GLY176L, GLY188L, GLY243H, GLY244H, GLY388L, HIS338L, ILE184L, ILE187L, ILE208H, ILE234H, ILE296L, ILE374L, LEU136H, LEU175H, LEU189L, LEU229H, LEU289H, LEU294L, LEU333H, LEU33L, LEU383L, LEU400H, LEU402H, LYS192L, LYS35L, LYS381L, LYS399H, MET193L, PHE129H, PHE230H, PHE292H, PHE292L, PHE390L, PRO170H, PRO185L, PRO191L, PRO203H, PRO291H, PRO291L, PRO297L, PRO375L, PRO377L, PRO392L, SER146H, SER172H, SER199L, SER200L, SER231H, SER239L, SER241L, SER307H, SER332H, SER403H, THR137H, THR148H, THR171H, THR196L, THR207H, THR209H, THR228H, THR286H, THR32L, THR385L, TYR173H, TYR206H, TYR214H, TYR387L, VAL194L, VAL205H, VAL247H, VAL295L, VAL384L
• I-M: ALA147I, ALA149I, ALA186M, ALA195M, ALA210I, ALA211I, ALA232I, ALA275M, ALA277M, ALA278M, ALA334I, ALA380M, ARG202I, ARG202M, ARG204I, ARG389M, ASN150I, ASN233I, ASN279M, ASN288I, ASN293I, ASN293M, ASN341I, ASN376M, ASN382M, ASN396I, ASP174I, ASP174M, ASP190M, ASP198M, ASP201I, ASP201M, ASP212I, ASP287I, ASP30I, ASP31I, ASP31M, ASP391M, CYS197M, GLN130I, GLU135I, GLU245I, GLU34M, GLU378M, GLU386M, GLU404I, GLY131I, GLY176M, GLY188M, GLY243I, GLY244I, GLY339I, GLY388M, HIS338M, ILE184M, ILE187M, ILE208I, ILE234I, ILE296M, ILE374M, ILE401I, LEU136I, LEU175I, LEU189M, LEU229I, LEU289I, LEU294M, LEU333I, LEU33M, LEU383M, LEU400I, LEU402I, LYS192M, LYS35M, LYS381M, LYS399I, MET193M, PHE230I, PHE292I, PHE292M, PHE390M, PRO170I, PRO185M, PRO191M, PRO203I, PRO291I, PRO297M, PRO343I, PRO377M, PRO392M, SER146I, SER172I, SER199M, SER200M, SER231I, SER239M, SER241M, SER332I, SER403I, THR137I, THR148I, THR171I, THR196M, THR207I, THR209I, THR228I, THR286I, THR298M, THR32M, THR385M, TYR173I, TYR206I, TYR214I, TYR387M, VAL194M, VAL205I, VAL247I, VAL276M, VAL295M, VAL384M
• K-L: ALA119K, ALA147K, ALA358K, ALA366L, ALA89L, ARG356K, ASN121K, ASN142K, ASN157K, ASN46L, GLN90L, GLU355K, GLU41L, GLY115L, GLY116K, GLY116L, GLY122K, GLY143K, GLY156K, LEU113L, LEU120K, LEU144K, MET145K, PRO114L, SER110L, SER111L, SER146K, SER361L, SER43L, THR112L, THR123K, THR364L, THR42L, THR44L, THR88L, TYR118K, TYR118L, TYR141K, TYR45L, VAL117K, VAL117L, VAL357K, VAL362L, VAL363L
• K-M: ALA119M, ALA358M, ALA366K, ALA89K, ARG356M, ASN121M, ASN142M, ASN157M, ASN46K, GLN90K, GLU355M, GLU41K, GLY115K, GLY115M, GLY116K, GLY116M, GLY122M, GLY143M, GLY156M, LEU113K, LEU113M, LEU120M, LEU144M, LEU159M, LEU47K, MET145M, PRO114K, PRO114M, SER110K, SER111K, SER146M, SER361K, SER43K, THR112K, THR123M, THR364K, THR42K, THR44K, THR48K, THR88K, TYR118K, TYR118M, TYR141M, TYR45K, VAL117K, VAL117M, VAL357M, VAL362K
• L-M: GLY115L, GLY116L, TYR118M, VAL117L