1W63

ap1 clathrin adaptor core

• Total interactions analyzed: 276
• Total true interactions: 68
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 149
  • Norm. En. per Res.: -2.5889
• Hub Node: A(9)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-61.5003	-64.5715	-259.679	-385.7508	149	45	8	14862	10	57	57
A-D	-6.85	21.0324	-61.5149	-47.3325	48	9	1	2719	0	20	18
A-F	0.0	21.5784	-41.1157	-19.5373	44	0	0	2176	1	29	34
A-G	0.0	-27.9061	-38.0687	-65.9748	62	11	0	2616	0	29	17
A-J	-14.3942	46.5801	-51.6947	-19.5088	52	5	0	2800	0	15	19
A-M	-10.1182	-25.689			11
A-N	-9.0298	-30.3241			6
A-R	0.0	-16.527			2
A-S	-52.9723	-122.3989			45
B-C	0.0	6.4967	-32.3035	-25.8068	39	1	0	1963	2	29	37
B-D	0.0	-1.1846	-11.1561	-12.3407	11	2	0	459	0	1	3
B-E	-4.047	21.4618	-58.1319	-40.717	46	3	1	2579	0	20	19
B-F	0.0	-1.2216	-8.9377	-10.1594	11	0	0	411	0	1	3
B-J	-6.2785	2.1121	-5.122	-9.2885	13	0	0	377	0	6	5
B-M	-70.9823	-160.2511			32
B-N	-28.5469	-83.8411			18
B-S	0.0	4.446			4
B-U	0.0	4.1041			6
C-D	-48.9153	-64.5633	-263.179	-376.6576	149	48	8	14893	10	57	57
C-N	-10.1088	-25.6919			11
C-T	-48.5964	-122.3967			44
D-N	-71.2029	-160.2476			31
D-S	0.0	-1.1047			6
D-T	0.0	4.4469			4
E-F	-48.9589	-64.5713	-264.231	-377.7612	150	45	8	14884	10	57	57
E-M	0.0	-28.0092			4
E-O	-10.1138	-25.6931			11
E-U	-48.608	-122.4017			44
F-M	-22.9126	-79.4669			21
F-O	-66.1415	-160.2505			30
F-U	0.0	4.4464			4
G-H	-48.9241	-64.5651	-263.486	-376.9752	151	44	8	14899	10	57	57
G-J	-6.744	21.0534	-63.2348	-48.9254	48	9	1	2807	0	20	18
G-L	0.0	27.8033			11
G-P	-10.1232	-25.6937			11
G-Q	-48.6129	-122.3976			44
G-R	0.0	-30.4566			4
H-I	0.0	5.4117	-39.484	-34.0723	43	1	0	2204	3	30	37
H-J	0.0	-1.1179	-11.4626	-12.5805	11	1	0	477	0	1	3
H-K	0.0	20.5152	-54.9397	-34.4245	44	2	1	2423	0	20	18
H-L	0.0	-1.1436			2
H-P	-69.4623	-160.2505			31
H-Q	0.0	4.4451			4
H-R	-33.976	-83.3031			21
H-W	0.0	3.311			6
I-J	-55.6266	-64.5683	-262.538	-382.7328	149	45	8	14850	10	57	57
I-R	-10.1212	-25.689			11
I-X	-52.3229	-122.4			45
J-Q	0.0	-2.3993			6
J-R	-66.1413	-160.2555			30
J-X	0.0	4.4457			4
K-L	-62.0499	-64.5738			27
K-P	0.0	-28.6052			4
K-V	-10.1268	-25.6843			11
K-W	-55.7997	-122.3969			44
L-P	-19.4203	-76.3832			16
L-V	-68.4352	-160.2493			32
L-W	0.0	4.4451			4
M-S	-2.9503	-35.257			11
M-U	-4.3405	-11.4436			5
N-S	-2.5323	-13.7009			5
N-T	-2.9484	-35.2574			11
O-U	-2.9444	-35.2562			11
P-Q	-2.9662	-35.2562			11
P-W	-4.0862	-11.5336			5
Q-R	-2.5606	-13.5317			5
R-X	-2.9437	-35.2599			11
V-W	-2.9399	-35.2585			11

Interface residues

• A-B: ALA17A, ALA437A, ALA446B, ALA447B, ALA487B, ALA526A, ALA529A, ALA536B, ALA537B, ALA543B, ALA563A, ALA568A, ALA579A, ARG15A, ARG18A, ARG419B, ARG520B, ARG522B, ARG523A, ARG528B, ARG536A, ARG562A, ARG577A, ARG583A, ARG8A, ASN440A, ASN516A, ASN516B, ASN567A, ASP3B, ASP416B, ASP435A, ASP436A, ASP513B, ASP515B, ASP518B, ASP521B, ASP533B, ASP553B, ASP556A, CYS479A, GLN443A, GLN474A, GLN479B, GLN483B, GLN512B, GLN560A, GLN561A, GLU14B, GLU17B, GLU32B, GLU454B, GLU482A, GLU539B, GLU544B, GLU550B, GLU551B, GLU558A, GLU565A, GLU582A, GLU588A, GLY523B, GLY524A, GLY552A, ILE382B, ILE442A, ILE451B, ILE525B, ILE548B, ILE550A, ILE555A, LEU18B, LEU482B, LEU485B, LEU519B, LEU527A, LEU529B, LEU530B, LEU542B, LEU547B, LEU559A, LEU569A, LEU580A, LEU581A, LYS12B, LYS282A, LYS35B, LYS36B, LYS415B, LYS420B, LYS45B, LYS490B, LYS532A, LYS538B, LYS545B, LYS571A, LYS572A, LYS576B, MET531A, MET576A, MET584A, MET587A, PHE570A, PRO439A, PRO517B, PRO534B, PRO546B, PRO585A, SER238A, SER514B, SER520A, SER531B, SER549A, SER549B, SER553A, SER554A, SER578A, THR16A, THR2B, THR446A, THR478B, THR486B, THR511B, THR519A, THR522A, THR528A, THR532B, THR535A, THR552B, TRP450B, TRP478A, TRP527B, TYR524B, TYR525A, TYR526B, TYR551A, TYR566A, TYR573A, VAL438A, VAL475A, VAL489B, VAL521A, VAL535B, VAL540B, VAL541B, VAL548A, VAL557A, VAL564A, VAL586A
• A-D: ALA430D, ALA462D, ARG458D, ASN225A, ASN435D, ASN461D, ASP236A, ASP437D, ASP439D, ASP460D, ASP463D, ASP471D, CYS433D, GLU234A, GLU279A, GLU434D, GLU464D, GLU467D, GLU498D, GLU501D, GLY230A, GLY239A, HIS188A, HIS235A, ILE240A, LEU432D, LEU436D, LEU465D, LEU466D, LYS186A, LYS282A, LYS402D, MET448D, PHE469D, PRO233A, PRO496D, SER229A, SER232A, SER238A, SER241A, SER281A, SER438D, SER459D, SER468D, THR431D, THR497D, THR499D, TYR231A
• A-F: ARG136A, ARG35A, ARG39A, ARG96A, ASN62F, ASN99F, ASP61F, ASP94A, ASP94F, ASP97F, ASP98A, GLN67A, GLN97A, GLU133A, GLU133F, GLU64F, GLU95A, GLU96F, HIS100A, HIS64A, ILE102F, LEU101A, LEU101F, LEU102A, LEU63F, LEU65F, LEU68A, LEU71A, LEU93A, LYS128F, LYS167A, LYS27F, LYS31F, LYS66F, LYS72A, LYS93F, PHE65A, PRO100F, PRO98F, SER131A, SER132A, THR60F, VAL168A, VAL99A
• A-G: ALA272A, ALA275G, ALA309G, ARG315A, ARG315G, ARG345A, ARG345G, ARG347A, ARG379A, ARG379G, ARG416A, ARG416G, ASN277G, ASN311A, ASN311G, ASN376A, ASN376G, CYS492A, CYS492G, GLN273A, GLN273G, GLN491A, GLN491G, GLU279G, GLU302A, GLU450A, GLU493A, GLU493G, GLU494A, GLU494G, GLU495A, GLU495G, GLU496A, GLU496G, GLY304A, GLY304G, GLY490A, GLY490G, HIS346A, HIS346G, ILE310G, ILE312G, LEU305A, LEU308A, LEU308G, LEU318G, LYS415A, PRO497A, PRO497G, SER303A, SER348G, SER414A, SER414G, SER489G, THR276A, THR276G, THR278G, THR280G, THR349G, TYR454G, VAL307A, VAL307G
• A-J: ALA349J, ALA352J, ALA356J, ALA388J, ARG390J, ARG458J, ARG543A, ASN350J, ASN542A, ASP397J, ASP503A, ASP507A, CYS391J, CYS539A, GLN348J, GLN386J, GLN400J, GLN499A, GLU385J, GLU389J, GLU426J, GLU502A, GLU504A, GLU510A, ILE351J, ILE544A, ILE550A, LEU355J, LEU395J, LEU396J, LEU506A, LYS359J, LYS424J, LYS545A, LYS546A, SER347J, SER387J, SER393J, SER427J, THR394J, THR401J, THR501A, THR538A, THR540A, TYR421J, TYR425J, VAL384J, VAL392J, VAL428J, VAL500A, VAL541A, VAL547A
• A-M: ARG18A, ARG434A, ASP105M, ASP399A, ASP435A, GLU22A, GLU353M, HIS140M, LYS296M, LYS298M, LYS352M
• A-N: ARG6A, ARG8A, ASN320A, GLU337N, GLU9A, TYR166N
• A-R: ARG167R, GLU496A
• A-S: ARG166A, ARG248A, ARG251A, ARG28S, ARG364A, ARG42S, ARG83A, ARG8A, ASN323A, ASP115S, ASP122S, ASP125S, ASP145S, ASP242A, ASP25S, ASP358A, ASP75S, ASP81A, ASP94A, CYS47S, GLU108S, GLU116S, GLU146S, GLU200A, GLU234A, GLU291A, GLU51S, GLY120S, HIS188A, HIS192A, HIS235A, HIS57A, HIS64A, LEU91A, LYS128S, LYS129S, LYS133S, LYS155A, LYS156A, LYS322A, LYS45S, LYS78A, SER48S, THR126S, THR80A
• B-C: ARG136C, ARG35C, ARG39C, ARG96C, ASN62B, ASN99B, ASP132B, ASP61B, ASP94B, ASP94C, ASP97B, ASP98C, GLN67C, GLN97C, GLU133C, GLU64B, GLU69C, GLU95C, GLU96B, HIS64C, ILE102B, LEU101B, LEU102C, LEU63B, LEU65B, LEU68C, LYS128B, LYS167C, LYS27B, LYS31B, LYS66B, LYS93B, PHE65C, PRO100B, PRO98B, SER131C, SER132C, THR60B, VAL99C
• B-D: ASN404D, ASN435D, ASP3B, ASP437D, GLN400D, LYS402D, SER438D, THR2B, THR401D, VAL403D, VAL407D
• B-E: ALA430B, ALA462B, ARG458B, ASN225E, ASN435B, ASN461B, ASP236E, ASP437B, ASP439B, ASP460B, ASP463B, CYS433B, GLU234E, GLU434B, GLU464B, GLU467B, GLU498B, GLU501B, GLY230E, GLY239E, HIS188E, HIS235E, ILE240E, LEU432B, LEU436B, LEU465B, LEU466B, LYS186E, LYS282E, LYS402B, MET448B, PHE469B, PRO233E, PRO496B, SER229E, SER232E, SER238E, SER241E, SER281E, SER438B, SER459B, SER468B, THR431B, THR497B, THR499B, TYR231E
• B-F: ASN404B, ASN435B, ASP3F, ASP437B, GLN400B, LYS402B, SER438B, THR2F, THR401B, VAL403B, VAL407B
• B-J: ARG247J, HIS250J, HIS319J, LEU248J, LYS232B, LYS282J, LYS283J, PRO246J, PRO287J, PRO557B, SER249J, THR245J, THR558B
• B-M: ALA75M, ARG108B, ARG22M, ARG304M, ARG393M, ASN329B, ASP115M, ASP119M, ASP127M, ASP150B, ASP24M, ASP366B, ASP368B, ASP475B, GLU112M, GLU116M, GLU186B, GLU189B, GLU216B, GLU476B, GLU583B, GLY568B, LEU570B, LYS147B, LYS346M, LYS67B, LYS72M, LYS73M, LYS78B, LYS86M, PHE134M, SER78M
• B-N: ARG191N, ARG268N, ARG410N, ASP25B, ASP3B, ASP417N, ASP53B, ASP82B, GLU193N, GLU261N, GLU311N, GLU381N, HIS239N, LYS11B, LYS12B, LYS19B, LYS379N, LYS5B
• B-S: ASP102S, GLU100S, GLU14B, LYS12B
• B-U: ASP471B, GLU136U, GLU464B, GLU467B, LYS129U, LYS133U
• C-D: ALA17C, ALA437C, ALA446D, ALA447D, ALA487D, ALA526C, ALA529C, ALA536D, ALA537D, ALA543D, ALA563C, ALA568C, ALA579C, ARG15C, ARG18C, ARG419D, ARG520D, ARG522D, ARG523C, ARG528D, ARG536C, ARG562C, ARG577C, ARG583C, ARG8C, ASN440C, ASN516C, ASN516D, ASN567C, ASP3D, ASP416D, ASP435C, ASP436C, ASP513D, ASP515D, ASP518D, ASP521D, ASP533D, ASP553D, ASP556C, CYS479C, GLN443C, GLN474C, GLN479D, GLN483D, GLN512D, GLN560C, GLN561C, GLU14D, GLU17D, GLU32D, GLU454D, GLU482C, GLU539D, GLU544D, GLU550D, GLU551D, GLU558C, GLU565C, GLU582C, GLU588C, GLY523D, GLY524C, GLY552C, ILE382D, ILE442C, ILE451D, ILE525D, ILE548D, ILE550C, ILE555C, LEU18D, LEU482D, LEU485D, LEU519D, LEU527C, LEU529D, LEU530D, LEU542D, LEU547D, LEU559C, LEU569C, LEU580C, LEU581C, LYS12D, LYS282C, LYS35D, LYS36D, LYS415D, LYS420D, LYS45D, LYS490D, LYS532C, LYS538D, LYS545D, LYS571C, LYS572C, LYS576D, MET531C, MET576C, MET584C, MET587C, PHE570C, PRO439C, PRO517D, PRO534D, PRO546D, PRO585C, SER238C, SER514D, SER520C, SER531D, SER549C, SER549D, SER553C, SER554C, SER578C, THR16C, THR2D, THR446C, THR478D, THR486D, THR511D, THR519C, THR522C, THR528C, THR532D, THR535C, THR552D, TRP450D, TRP478C, TRP527D, TYR524D, TYR525C, TYR526D, TYR551C, TYR566C, TYR573C, VAL438C, VAL475C, VAL489D, VAL521C, VAL535D, VAL540D, VAL541D, VAL548C, VAL557C, VAL564C, VAL586C
• C-N: ARG18C, ARG434C, ASP105N, ASP399C, ASP435C, GLU22C, GLU353N, HIS140N, LYS296N, LYS298N, LYS352N
• C-T: ARG166C, ARG248C, ARG251C, ARG28T, ARG364C, ARG42T, ARG83C, ARG8C, ASN323C, ASP115T, ASP122T, ASP125T, ASP145T, ASP242C, ASP25T, ASP358C, ASP75T, ASP81C, ASP94C, CYS47T, GLU108T, GLU116T, GLU146T, GLU200C, GLU234C, GLU291C, GLU51T, GLY120T, HIS188C, HIS192C, HIS235C, HIS57C, HIS64C, LEU91C, LYS128T, LYS129T, LYS133T, LYS155C, LYS156C, LYS322C, LYS45T, LYS78C, SER48T, THR80C
• D-N: ALA75N, ARG108D, ARG22N, ARG304N, ARG393N, ASN329D, ASP115N, ASP119N, ASP127N, ASP150D, ASP24N, ASP366D, ASP368D, ASP475D, GLU112N, GLU116N, GLU186D, GLU189D, GLU216D, GLU476D, GLU583D, LEU570D, LYS147D, LYS346N, LYS67D, LYS72N, LYS73N, LYS78D, LYS86N, PHE134N, TYR136D
• D-S: ASP471D, GLU136S, GLU464D, GLU467D, LYS129S, LYS133S
• D-T: ASP102T, GLU100T, GLU14D, LYS12D
• E-F: ALA17E, ALA437E, ALA446F, ALA447F, ALA487F, ALA526E, ALA529E, ALA536F, ALA537F, ALA543F, ALA563E, ALA568E, ALA579E, ARG15E, ARG18E, ARG419F, ARG520F, ARG522F, ARG523E, ARG528F, ARG536E, ARG562E, ARG577E, ARG583E, ARG8E, ASN440E, ASN516E, ASN516F, ASN567E, ASP3F, ASP416F, ASP435E, ASP436E, ASP513F, ASP515F, ASP518F, ASP521F, ASP533F, ASP553F, ASP556E, CYS479E, GLN443E, GLN474E, GLN479F, GLN483F, GLN512F, GLN560E, GLN561E, GLU14F, GLU17F, GLU32F, GLU454F, GLU482E, GLU539F, GLU544F, GLU550F, GLU551F, GLU558E, GLU565E, GLU582E, GLU588E, GLY523F, GLY524E, GLY552E, ILE382F, ILE442E, ILE451F, ILE525F, ILE548F, ILE550E, ILE555E, LEU18F, LEU482F, LEU485F, LEU519F, LEU527E, LEU529F, LEU530F, LEU542F, LEU547F, LEU559E, LEU569E, LEU580E, LEU581E, LYS12F, LYS282E, LYS35F, LYS36F, LYS415F, LYS420F, LYS45F, LYS490F, LYS532E, LYS538F, LYS545F, LYS571E, LYS572E, LYS576F, MET531E, MET576E, MET584E, MET587E, PHE570E, PRO439E, PRO517F, PRO534F, PRO546F, PRO585E, SER238E, SER40F, SER514F, SER520E, SER531F, SER549E, SER549F, SER553E, SER554E, SER578E, THR16E, THR2F, THR446E, THR478F, THR486F, THR511F, THR519E, THR522E, THR528E, THR532F, THR535E, THR552F, TRP450F, TRP478E, TRP527F, TYR524F, TYR525E, TYR526F, TYR551E, TYR566E, TYR573E, VAL438E, VAL475E, VAL489F, VAL521E, VAL535F, VAL540F, VAL541F, VAL548E, VAL557E, VAL564E, VAL586E
• E-M: ARG6E, ARG8E, GLU337M, GLU9E
• E-O: ARG18E, ARG434E, ASP105O, ASP399E, ASP435E, GLU22E, GLU353O, HIS140O, LYS296O, LYS298O, LYS352O
• E-U: ARG166E, ARG248E, ARG251E, ARG28U, ARG364E, ARG42U, ARG83E, ARG8E, ASN323E, ASP115U, ASP122U, ASP125U, ASP145U, ASP242E, ASP25U, ASP358E, ASP75U, ASP81E, ASP94E, CYS47U, GLU108U, GLU116U, GLU146U, GLU200E, GLU234E, GLU291E, GLU51U, GLY120U, HIS188E, HIS192E, HIS235E, HIS57E, HIS64E, LEU91E, LYS128U, LYS129U, LYS133U, LYS155E, LYS156E, LYS322E, LYS45U, LYS78E, SER48U, THR80E
• F-M: ARG191M, ARG201M, ARG268M, ARG410M, ASP25F, ASP3F, ASP417M, ASP53F, ASP82F, GLU193M, GLU261M, GLU311M, GLU381M, HIS239M, LYS11F, LYS12F, LYS19F, LYS237M, LYS379M, LYS5F, MET86F
• F-O: ALA75O, ARG108F, ARG22O, ARG304O, ARG393O, ASN329F, ASP115O, ASP119O, ASP127O, ASP150F, ASP24O, ASP366F, ASP368F, ASP475F, GLU112O, GLU116O, GLU186F, GLU189F, GLU216F, GLU476F, GLU583F, LEU570F, LYS147F, LYS346O, LYS67F, LYS72O, LYS73O, LYS78F, LYS86O, PHE134O
• F-U: ASP102U, GLU100U, GLU14F, LYS12F
• G-H: ALA17G, ALA437G, ALA446H, ALA447H, ALA487H, ALA526G, ALA529G, ALA536H, ALA537H, ALA543H, ALA563G, ALA568G, ALA579G, ARG15G, ARG18G, ARG419H, ARG520H, ARG522H, ARG523G, ARG528H, ARG536G, ARG562G, ARG577G, ARG583G, ARG8G, ASN440G, ASN516G, ASN516H, ASN567G, ASP3H, ASP416H, ASP435G, ASP436G, ASP513H, ASP515H, ASP518H, ASP521H, ASP533H, ASP553H, ASP556G, CYS479G, GLN443G, GLN474G, GLN479H, GLN483H, GLN512H, GLN560G, GLN561G, GLU14H, GLU17H, GLU32H, GLU454H, GLU482G, GLU539H, GLU544H, GLU550H, GLU551H, GLU558G, GLU565G, GLU582G, GLU588G, GLY523H, GLY524G, GLY552G, ILE382H, ILE442G, ILE451H, ILE525H, ILE548H, ILE550G, ILE555G, LEU18H, LEU482H, LEU485H, LEU519H, LEU527G, LEU529H, LEU530H, LEU542H, LEU547H, LEU559G, LEU569G, LEU580G, LEU581G, LYS12H, LYS282G, LYS35H, LYS36H, LYS415H, LYS420H, LYS45H, LYS490H, LYS532G, LYS538H, LYS545H, LYS571G, LYS572G, LYS576H, MET531G, MET576G, MET584G, MET587G, PHE570G, PRO439G, PRO517H, PRO534H, PRO546H, PRO585G, SER238G, SER281G, SER40H, SER514H, SER520G, SER531H, SER549G, SER549H, SER553G, SER554G, SER578G, THR16G, THR2H, THR446G, THR478H, THR486H, THR511H, THR519G, THR522G, THR528G, THR532H, THR535G, THR552H, TRP450H, TRP478G, TRP527H, TYR524H, TYR525G, TYR526H, TYR551G, TYR566G, TYR573G, VAL438G, VAL475G, VAL489H, VAL521G, VAL535H, VAL540H, VAL541H, VAL548G, VAL557G, VAL564G, VAL586G
• G-J: ALA430J, ALA462J, ARG458J, ASN225G, ASN435J, ASN461J, ASP236G, ASP437J, ASP439J, ASP460J, ASP463J, ASP471J, CYS433J, GLU234G, GLU279G, GLU434J, GLU464J, GLU467J, GLU498J, GLU501J, GLY230G, GLY239G, HIS188G, HIS235G, ILE240G, LEU432J, LEU436J, LEU465J, LEU466J, LYS186G, LYS282G, LYS402J, MET448J, PHE469J, PRO233G, PRO496J, SER229G, SER232G, SER238G, SER241G, SER281G, SER438J, SER459J, SER468J, THR431J, THR497J, THR499J, TYR231G
• G-L: ARG96G, ASP61L, ASP94G, ASP97L, ASP98G, GLU95G, GLU96L, HIS100G, HIS64G, LYS66L, LYS93L
• G-P: ARG18G, ARG434G, ASP105P, ASP399G, ASP435G, GLU22G, GLU353P, HIS140P, LYS296P, LYS298P, LYS352P
• G-Q: ARG166G, ARG248G, ARG251G, ARG28Q, ARG364G, ARG42Q, ARG83G, ARG8G, ASN323G, ASP115Q, ASP122Q, ASP125Q, ASP145Q, ASP242G, ASP25Q, ASP358G, ASP75Q, ASP81G, ASP94G, CYS47Q, GLU108Q, GLU116Q, GLU146Q, GLU200G, GLU234G, GLU291G, GLU51Q, GLY120Q, HIS188G, HIS192G, HIS235G, HIS57G, HIS64G, LEU91G, LYS128Q, LYS129Q, LYS133Q, LYS155G, LYS156G, LYS322G, LYS45Q, LYS78G, SER48Q, THR80G
• G-R: ARG6G, ARG8G, GLU337R, GLU9G
• H-I: ARG103H, ARG136I, ARG35I, ARG39I, ARG96I, ASN62H, ASN99H, ASP132H, ASP61H, ASP94H, ASP94I, ASP97H, ASP98I, GLN59H, GLN67I, GLN97I, GLU133H, GLU133I, GLU64H, GLU69I, GLU95I, GLU96H, HIS64I, ILE102H, LEU101H, LEU102I, LEU63H, LEU65H, LEU68I, LYS128H, LYS167I, LYS27H, LYS31H, LYS66H, LYS72I, LYS93H, PHE65I, PRO100H, PRO98H, SER131I, SER132I, THR60H, VAL99I
• H-J: ASN404J, ASN435J, ASP3H, ASP437J, GLN400J, LYS402J, SER438J, THR2H, THR401J, VAL403J, VAL407J
• H-K: ALA430H, ALA462H, ARG458H, ASN225K, ASN435H, ASN461H, ASP236K, ASP437H, ASP439H, ASP460H, ASP463H, CYS433H, GLU234K, GLU434H, GLU464H, GLU467H, GLU498H, GLU501H, GLY230K, GLY239K, HIS188K, HIS235K, LEU432H, LEU436H, LEU465H, LEU466H, LYS186K, LYS282K, LYS402H, MET448H, PHE469H, PRO233K, PRO496H, SER229K, SER232K, SER238K, SER241K, SER281K, SER438H, SER459H, SER468H, THR431H, THR497H, TYR231K
• H-L: ASP3L, LYS402H
• H-P: ALA75P, ARG108H, ARG22P, ARG304P, ARG393P, ASN329H, ASP115P, ASP119P, ASP127P, ASP150H, ASP24P, ASP366H, ASP368H, ASP475H, GLU112P, GLU116P, GLU186H, GLU189H, GLU216H, GLU476H, GLU583H, LEU570H, LYS147H, LYS346P, LYS67H, LYS72P, LYS73P, LYS78H, LYS86P, PHE134P, TYR136H
• H-Q: ASP102Q, GLU100Q, GLU14H, LYS12H
• H-R: ARG191R, ARG268R, ARG410R, ASP235R, ASP25H, ASP3H, ASP417R, ASP53H, ASP82H, GLU193R, GLU261R, GLU311R, GLU381R, HIS239R, LYS11H, LYS12H, LYS19H, LYS237R, LYS379R, LYS5H, MET86H
• H-W: ASP471H, GLU136W, GLU464H, GLU467H, LYS129W, LYS133W
• I-J: ALA17I, ALA437I, ALA446J, ALA447J, ALA487J, ALA526I, ALA529I, ALA536J, ALA537J, ALA543J, ALA563I, ALA568I, ALA579I, ARG15I, ARG18I, ARG419J, ARG520J, ARG522J, ARG523I, ARG528J, ARG536I, ARG562I, ARG577I, ARG583I, ARG8I, ASN440I, ASN516I, ASN516J, ASN567I, ASP3J, ASP416J, ASP435I, ASP436I, ASP513J, ASP515J, ASP518J, ASP521J, ASP533J, ASP553J, ASP556I, CYS479I, GLN443I, GLN474I, GLN479J, GLN483J, GLN512J, GLN560I, GLN561I, GLU14J, GLU17J, GLU32J, GLU454J, GLU482I, GLU539J, GLU544J, GLU550J, GLU551J, GLU558I, GLU565I, GLU582I, GLU588I, GLY523J, GLY524I, GLY552I, ILE382J, ILE442I, ILE451J, ILE525J, ILE548J, ILE550I, ILE555I, LEU18J, LEU482J, LEU485J, LEU519J, LEU527I, LEU529J, LEU530J, LEU542J, LEU547J, LEU559I, LEU569I, LEU580I, LEU581I, LYS12J, LYS282I, LYS35J, LYS36J, LYS415J, LYS420J, LYS45J, LYS490J, LYS532I, LYS538J, LYS545J, LYS571I, LYS572I, LYS576J, MET531I, MET576I, MET584I, MET587I, PHE570I, PRO439I, PRO517J, PRO534J, PRO546J, PRO585I, SER238I, SER514J, SER520I, SER531J, SER549I, SER549J, SER553I, SER554I, SER578I, THR16I, THR2J, THR446I, THR478J, THR486J, THR511J, THR519I, THR522I, THR528I, THR532J, THR535I, THR552J, TRP450J, TRP478I, TRP527J, TYR524J, TYR525I, TYR526J, TYR551I, TYR566I, TYR573I, VAL438I, VAL475I, VAL489J, VAL521I, VAL535J, VAL540J, VAL541J, VAL548I, VAL557I, VAL564I, VAL586I
• I-R: ARG18I, ARG434I, ASP105R, ASP399I, ASP435I, GLU22I, GLU353R, HIS140R, LYS296R, LYS298R, LYS352R
• I-X: ARG166I, ARG248I, ARG251I, ARG28X, ARG364I, ARG42X, ARG83I, ARG8I, ASN323I, ASP115X, ASP122X, ASP125X, ASP145X, ASP242I, ASP25X, ASP358I, ASP75X, ASP81I, ASP94I, CYS47X, GLU108X, GLU116X, GLU146X, GLU200I, GLU234I, GLU291I, GLU51X, GLY120X, HIS188I, HIS192I, HIS235I, HIS57I, HIS64I, LEU91I, LYS128X, LYS129X, LYS133X, LYS155I, LYS156I, LYS322I, LYS45X, LYS78I, SER48X, THR126X, THR80I
• J-Q: ASP471J, GLU136Q, GLU464J, GLU467J, LYS129Q, LYS133Q
• J-R: ALA75R, ARG108J, ARG22R, ARG304R, ARG393R, ASN329J, ASP115R, ASP119R, ASP127R, ASP150J, ASP24R, ASP366J, ASP368J, ASP475J, GLU112R, GLU116R, GLU186J, GLU189J, GLU216J, GLU476J, GLU583J, LEU570J, LYS147J, LYS346R, LYS67J, LYS72R, LYS73R, LYS78J, LYS86R, PHE134R
• J-X: ASP102X, GLU100X, GLU14J, LYS12J
• K-L: ARG15K, ARG18K, ARG419L, ARG522L, ARG528L, ARG562K, ARG583K, ASP436K, ASP515L, ASP518L, ASP521L, GLN561K, GLU17L, GLU32L, GLU482K, GLU539L, GLU558K, GLU565K, LEU547L, LEU580K, LYS36L, LYS490L, LYS532K, LYS545L, LYS572K, SER553K, SER554K
• K-P: ARG6K, ARG8K, GLU337P, GLU9K
• K-V: ARG18K, ARG434K, ASP105V, ASP399K, ASP435K, GLU22K, GLU353V, HIS140V, LYS296V, LYS298V, LYS352V
• K-W: ARG166K, ARG248K, ARG251K, ARG28W, ARG364K, ARG42W, ARG83K, ARG8K, ASN323K, ASP115W, ASP122W, ASP125W, ASP145W, ASP242K, ASP25W, ASP358K, ASP75W, ASP81K, ASP94K, CYS47W, GLU108W, GLU116W, GLU146W, GLU200K, GLU234K, GLU291K, GLU51W, GLY120W, HIS188K, HIS192K, HIS235K, HIS57K, HIS64K, LEU91K, LYS128W, LYS129W, LYS133W, LYS155K, LYS156K, LYS322K, LYS45W, LYS78K, SER48W, THR80K
• L-P: ARG191P, ARG201P, ARG268P, ARG410P, ASP25L, ASP3L, ASP417P, ASP53L, GLU261P, GLU311P, GLU381P, LYS11L, LYS12L, LYS19L, LYS379P, LYS5L
• L-V: ALA75V, ARG108L, ARG22V, ARG304V, ARG393V, ASN329L, ASP115V, ASP119V, ASP127V, ASP150L, ASP24V, ASP366L, ASP368L, ASP475L, GLU112V, GLU116V, GLU186L, GLU189L, GLU216L, GLU476L, GLU583L, GLY568L, LEU570L, LYS147L, LYS346V, LYS67L, LYS72V, LYS73V, LYS78L, LYS86V, PHE134V, SER78V
• L-W: ASP102W, GLU100W, GLU14L, LYS12L
• M-S: ARG191M, ARG33S, ARG421M, ARG53S, ASP54S, GLU232M, GLU234M, GLU34S, HIS272M, LYS26S, LYS30S
• M-U: ASP139U, ASP321M, GLU143U, GLU146U, LYS333M
• N-S: ASP139S, ASP321N, GLU143S, GLU146S, LYS333N
• N-T: ARG191N, ARG33T, ARG421N, ARG53T, ASP54T, GLU232N, GLU234N, GLU34T, HIS272N, LYS26T, LYS30T
• O-U: ARG191O, ARG33U, ARG421O, ARG53U, ASP54U, GLU232O, GLU234O, GLU34U, HIS272O, LYS26U, LYS30U
• P-Q: ARG191P, ARG33Q, ARG421P, ARG53Q, ASP54Q, GLU232P, GLU234P, GLU34Q, HIS272P, LYS26Q, LYS30Q
• P-W: ASP139W, ASP321P, GLU143W, GLU146W, LYS333P
• Q-R: ASP139Q, ASP321R, GLU143Q, GLU146Q, LYS333R
• R-X: ARG191R, ARG33X, ARG421R, ARG53X, ASP54X, GLU232R, GLU234R, GLU34X, HIS272R, LYS26X, LYS30X
• V-W: ARG191V, ARG33W, ARG421V, ARG53W, ASP54W, GLU232V, GLU234V, GLU34W, HIS272V, LYS26W, LYS30W