1W4C

p4 protein from bacteriophage phi12 apo state

• Total interactions analyzed: 276
• Total true interactions: 47
• Strongest Interaction:
  • Chains: A-F
  • Int. Res.: 197
  • Norm. En. per Res.: -3.4407
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-98.9391	-59.3117	-454.402	-612.6527	182	24	10	18096	5	64	54
A-F	-139.1666	-53.8871	-484.772	-677.8257	197	35	11	19623	5	73	63
A-G	0.0	113.3012	-57.165	56.1362	40	1	0	2526	0	16	14
B-C	-112.6944	-30.9155	-445.432	-589.0419	194	27	10	19288	5	75	65
B-K	0.0	0.0	-1.4874	-1.4874	8	0	5	319	0	0	0
B-L	0.0	110.1448	-52.026	58.1188	41	0	0	2374	0	14	14
C-D	-99.4167	-48.9669	-434.319	-582.7025	193	33	10	18937	5	69	61
C-J	0.0	0.0	-1.5706	-1.5706	8	0	5	327	0	0	0
C-K	0.0	130.925	-61.9524	68.9727	51	1	1	2798	0	14	16
D-E	-89.5355	-56.8028	-447.569	-593.9073	178	22	11	17920	5	64	53
D-J	0.0	114.9245	-57.964	56.9605	41	0	0	2581	0	18	15
E-F	-111.6141	-41.336	-487.303	-640.2531	197	31	11	19779	5	74	66
E-I	0.0	107.1427	-49.3134	57.8293	41	0	0	2404	0	16	14
F-G	0.0	0.0	-1.3997	-1.3997	8	0	5	299	0	0	0
F-H	0.0	110.929	-55.6354	55.2936	40	0	0	2504	0	15	14
G-H	-77.4421	-54.6508	-429.054	-561.1469	190	22	11	18740	5	68	61
G-L	-101.894	-59.8458	-417.351	-579.0908	177	16	9	17547	5	63	55
H-I	-106.033	-33.879	-441.186	-581.098	179	24	10	17772	5	67	52
H-S	0.0	0.0	-0.0151	-0.0151	5	0	0	6	0	4	4
H-X	-7.6036	-18.863			2
I-J	-90.9415	-52.5032	-440.742	-584.1867	177	18	12	17880	5	66	54
I-M	-15.8561	-24.059	83.811	43.8959	44	16	0	2527	2	22	19
I-N	0.0	0.4305	-3.1481	-2.7176	8	0	0	237	0	5	5
J-K	-121.9244	-29.8747	-455.729	-607.5281	195	30	11	19249	5	74	64
J-M	0.0	0.0	-0.0099	-0.0099	2	0	0	5	0	1	0
K-L	-114.2543	-57.1351	-472.654	-644.0434	199	40	10	20120	5	72	63
M-N	-103.6599	-33.3873	-496.827	-633.8742	195	32	12	20075	5	75	64
M-R	-128.6283	-30.3903	-469.309	-628.3277	192	32	10	19219	6	74	64
M-S	0.0	123.0341	-53.4435	69.5906	54	0	0	2742	0	15	14
N-O	-126.5797	-20.6076	-501.234	-648.4213	196	39	10	20330	5	77	65
N-X	0.0	112.3082			5
O-P	-105.2544	-32.2372	-458.45	-595.9416	198	26	11	19653	5	76	66
O-V	0.0	0.0	-1.509	-1.509	8	0	5	310	0	0	0
O-W	0.0	125.3544	0.0	125.3544	6	0	0	0	0	0	0
P-Q	-110.7567	-27.6248	-494.144	-632.5255	195	29	10	19879	5	75	64
P-V	0.0	129.228	-59.7867	69.4413	50	0	1	2749	0	14	15
Q-R	-115.2519	-30.4956	-488.887	-634.6345	194	30	10	19747	5	75	66
Q-T	0.0	0.0	-1.3674	-1.3674	8	0	5	306	0	0	0
Q-U	0.0	113.8246	-53.7026	60.122	39	0	1	2401	0	14	14
R-S	0.0	0.0	-1.243	-1.243	8	0	5	274	0	0	0
R-T	0.0	125.5833	-55.5393	70.044	53	0	0	2673	0	13	14
S-T	-116.7552	-29.3331	-493.732	-639.8203	197	32	11	19619	5	75	65
S-X	-80.3042	-57.7735			32
T-U	-114.0207	-64.9872	-464.032	-643.04	198	36	10	19753	5	71	63
U-V	-86.313	-41.9908	-424.265	-552.5688	172	18	10	17388	5	63	52
V-W	-111.6135	-30.1068	-1.615	-143.3354	56	0	0	315	0	5	5
W-X	-119.8138	-64.9511			42

Interface residues

• A-B: ALA11A, ALA122A, ALA142B, ALA146B, ALA154B, ALA15A, ALA16A, ALA177B, ALA179B, ALA19A, ALA20A, ALA211B, ALA220A, ALA222A, ALA223A, ALA249A, ALA48A, ALA56A, ALA63B, ALA76A, ALA7A, ARG14A, ARG157B, ARG178B, ARG184B, ARG209A, ARG209B, ARG225A, ARG251A, ARG272A, ARG279A, ARG65B, ARG96A, ASN133B, ASN166B, ASN170B, ASN193B, ASN234B, ASN238B, ASN253A, ASN62B, ASN88B, ASP101A, ASP151B, ASP168B, ASP174B, ASP175B, ASP189B, ASP213A, ASP217A, ASP239B, ASP6A, ASP78A, CYS109A, GLN17A, GLN182B, GLN278A, GLN64B, GLN93A, GLU105A, GLU145B, GLU160B, GLU244A, GLU248A, GLU275A, GLU290B, GLU52B, GLU71A, GLU77A, GLY104A, GLY108A, GLY124A, GLY135B, GLY144B, GLY148B, GLY149B, GLY159B, GLY164B, GLY219A, GLY226A, GLY274A, GLY276A, GLY79A, GLY94A, GLY97A, HIS141B, HIS183B, HIS22A, HIS291B, HIS3A, HIS95A, ILE176B, ILE186B, ILE207B, ILE218A, ILE242B, ILE2A, LEU102A, LEU106A, LEU139B, LEU13A, LEU162B, LEU181B, LEU214A, LEU215A, LEU245A, LEU277A, LEU294B, LEU4A, LEU99A, LYS12A, LYS131B, LYS136B, LYS150B, LYS152B, LYS192B, LYS241B, LYS247A, LYS75A, LYS8A, LYS92A, MET125A, MET180B, MET1A, MET221A, MET91A, PHE10A, PHE158B, PHE169B, PHE172B, PHE212A, PHE59B, PHE90B, PRO111A, PRO138B, PRO161B, PRO235B, SER110A, SER123A, SER163B, SER190B, SER208B, SER216A, SER224A, SER237B, SER250A, SER252A, SER254A, SER256A, SER292B, SER53B, SER80A, SER82A, SER9A, THR103A, THR137B, THR155B, THR167B, THR236B, THR23A, THR255A, THR273A, THR33A, TRP29A, TRP98A, TYR153B, TYR165B, TYR18A, TYR288B, TYR5A, VAL107A, VAL126A, VAL140B, VAL156B, VAL171B, VAL185B, VAL187B, VAL194B, VAL293B, VAL67B, VAL81A, VAL83A
• A-F: ALA11F, ALA122F, ALA142A, ALA146A, ALA154A, ALA15F, ALA16F, ALA177A, ALA179A, ALA19F, ALA20F, ALA220F, ALA222F, ALA223F, ALA249F, ALA311F, ALA48F, ALA56F, ALA63A, ALA76F, ALA7F, ARG14F, ARG157A, ARG178A, ARG184A, ARG209A, ARG209F, ARG225F, ARG251F, ARG272F, ARG279F, ARG65A, ARG96F, ASN133A, ASN166A, ASN170A, ASN193A, ASN234A, ASN238A, ASN253F, ASN318F, ASN62A, ASN88A, ASP101F, ASP151A, ASP168A, ASP174A, ASP175A, ASP189A, ASP213F, ASP217F, ASP239A, ASP240A, ASP240F, ASP6F, ASP78F, CYS109F, GLN17F, GLN182A, GLN278F, GLN313F, GLN64A, GLN93F, GLU105F, GLU145A, GLU160A, GLU244F, GLU248F, GLU275F, GLU290A, GLU52A, GLU71F, GLU77F, GLY104F, GLY108F, GLY124F, GLY130A, GLY132A, GLY135A, GLY144A, GLY148A, GLY149A, GLY159A, GLY164A, GLY219F, GLY226F, GLY274F, GLY276F, GLY309F, GLY79F, GLY89A, GLY94F, GLY97F, HIS141A, HIS183A, HIS22F, HIS291A, HIS3F, HIS95F, ILE176A, ILE186A, ILE188A, ILE207A, ILE218F, ILE2F, ILE312F, LEU102F, LEU106F, LEU139A, LEU13F, LEU162A, LEU181A, LEU214F, LEU215F, LEU245F, LEU277F, LEU294A, LEU321F, LEU4F, LEU99F, LYS12F, LYS131A, LYS136A, LYS150A, LYS152A, LYS192A, LYS247F, LYS310F, LYS317F, LYS75F, LYS8F, LYS92F, MET125F, MET180A, MET1F, MET221F, MET91F, PHE10F, PHE158A, PHE169A, PHE172A, PHE212F, PHE59A, PHE90A, PRO111F, PRO138A, PRO161A, PRO235A, SER110F, SER123F, SER134A, SER163A, SER190A, SER208A, SER216F, SER224F, SER237A, SER250F, SER252F, SER254F, SER256F, SER292A, SER308F, SER53A, SER80F, SER82F, SER9F, THR103F, THR137A, THR155A, THR167A, THR236A, THR23F, THR255F, THR273F, THR314F, THR33F, TRP267A, TRP29F, TRP98F, TYR153A, TYR165A, TYR18F, TYR288A, TYR5F, VAL107F, VAL140A, VAL156A, VAL171A, VAL185A, VAL187A, VAL194A, VAL293A, VAL315F, VAL67A, VAL81F, VAL83F
• A-G: ASN133A, ASN318G, ASP262A, ASP262G, ASP264A, ASP264G, ASP319G, GLN268A, GLN268G, GLN285A, GLN285G, GLN306G, GLU266A, GLU266G, GLY132A, HIS282A, HIS282G, ILE259A, ILE259G, ILE312G, ILE316G, LEU284A, LEU284G, LEU321G, LYS131A, LYS241A, SER260A, SER260G, THR261A, THR261G, THR281A, THR281G, THR283A, THR283G, TRP267A, TRP267G, VAL263A, VAL263G, VAL269G, VAL315G
• B-C: ALA11B, ALA122B, ALA142C, ALA146C, ALA154C, ALA15B, ALA16B, ALA177C, ALA179C, ALA19B, ALA20B, ALA220B, ALA222B, ALA223B, ALA249B, ALA311B, ALA48B, ALA56B, ALA63C, ALA76B, ALA7B, ARG14B, ARG157C, ARG178C, ARG184C, ARG209B, ARG209C, ARG225B, ARG251B, ARG272B, ARG279B, ARG65C, ARG96B, ASN133C, ASN166C, ASN170C, ASN193C, ASN234C, ASN238C, ASN253B, ASN62C, ASN88C, ASP101B, ASP151C, ASP168C, ASP174C, ASP175C, ASP189C, ASP213B, ASP217B, ASP239C, ASP240B, ASP240C, ASP6B, ASP78B, CYS109B, GLN17B, GLN182C, GLN278B, GLN313B, GLN64C, GLN93B, GLU105B, GLU145C, GLU160C, GLU244B, GLU248B, GLU275B, GLU290C, GLU52C, GLU71B, GLU77B, GLY104B, GLY108B, GLY124B, GLY130C, GLY132C, GLY135C, GLY144C, GLY148C, GLY149C, GLY159C, GLY164C, GLY219B, GLY226B, GLY274B, GLY276B, GLY309B, GLY79B, GLY94B, GLY97B, HIS141C, HIS183C, HIS22B, HIS291C, HIS3B, HIS95B, ILE176C, ILE186C, ILE207C, ILE218B, ILE242C, ILE2B, ILE312B, LEU102B, LEU106B, LEU139C, LEU13B, LEU162C, LEU215B, LEU245B, LEU277B, LEU294C, LEU321B, LEU4B, LEU99B, LYS12B, LYS131C, LYS136C, LYS150C, LYS152C, LYS192C, LYS241B, LYS241C, LYS247B, LYS310B, LYS317B, LYS75B, LYS8B, MET125B, MET180C, MET1B, MET221B, MET91B, PHE10B, PHE158C, PHE169C, PHE172C, PHE212B, PHE59C, PHE90C, PRO111B, PRO138C, PRO161C, PRO235C, SER110B, SER123B, SER134C, SER163C, SER190C, SER208C, SER216B, SER224B, SER237C, SER250B, SER252B, SER254B, SER256B, SER292C, SER308B, SER53C, SER80B, SER82B, SER9B, THR103B, THR137C, THR155C, THR167C, THR236C, THR23B, THR255B, THR273B, THR314B, THR33B, TRP267C, TRP29B, TRP98B, TYR153C, TYR165C, TYR18B, TYR288C, TYR5B, VAL107B, VAL140C, VAL156C, VAL171C, VAL185C, VAL187C, VAL194C, VAL243C, VAL293C, VAL67C, VAL81B, VAL83B
• B-K: ALA311B, ALA311K, GLY309B, GLY309K, ILE312B, ILE312K, VAL315B, VAL315K
• B-L: ASN133L, ASN318B, ASP262B, ASP262L, ASP264B, ASP264L, ASP319B, GLN268B, GLN268L, GLN285B, GLN285L, GLN306B, GLU266B, GLU266L, GLY132L, HIS282B, HIS282L, ILE259B, ILE259L, ILE312B, ILE316B, LEU284B, LEU284L, LEU321B, LYS131L, LYS241L, SER260B, SER260L, THR261B, THR261L, THR281B, THR281L, THR283B, THR283L, TRP267B, TRP267L, VAL263B, VAL263L, VAL269B, VAL269L, VAL315B
• C-D: ALA11C, ALA122C, ALA142D, ALA146D, ALA154D, ALA15C, ALA16C, ALA177D, ALA179D, ALA19C, ALA20C, ALA220C, ALA222C, ALA223C, ALA249C, ALA311C, ALA48C, ALA56C, ALA63D, ALA76C, ALA7C, ARG14C, ARG157D, ARG178D, ARG209C, ARG209D, ARG225C, ARG251C, ARG272C, ARG279C, ARG65D, ARG96C, ASN133D, ASN166D, ASN170D, ASN193D, ASN234D, ASN238D, ASN253C, ASN318C, ASN62D, ASN88D, ASP101C, ASP151D, ASP168D, ASP174D, ASP175D, ASP189D, ASP213C, ASP217C, ASP239D, ASP240C, ASP240D, ASP6C, ASP78C, CYS109C, GLN17C, GLN182D, GLN278C, GLN313C, GLN64D, GLN93C, GLU105C, GLU145D, GLU160D, GLU244C, GLU248C, GLU275C, GLU290D, GLU52D, GLU71C, GLU77C, GLY104C, GLY108C, GLY124C, GLY130D, GLY132D, GLY135D, GLY144D, GLY148D, GLY149D, GLY159D, GLY164D, GLY219C, GLY226C, GLY274C, GLY276C, GLY309C, GLY79C, GLY94C, GLY97C, HIS141D, HIS183D, HIS22C, HIS291D, HIS3C, HIS95C, ILE176D, ILE186D, ILE207D, ILE218C, ILE242D, ILE2C, ILE312C, LEU102C, LEU106C, LEU139D, LEU13C, LEU162D, LEU215C, LEU245C, LEU277C, LEU294D, LEU321C, LEU4C, LEU99C, LYS12C, LYS131D, LYS136D, LYS150D, LYS152D, LYS192D, LYS241C, LYS247C, LYS310C, LYS317C, LYS75C, LYS8C, MET125C, MET180D, MET1C, MET221C, MET91C, PHE10C, PHE158D, PHE169D, PHE172D, PHE212C, PHE59D, PHE90D, PRO111C, PRO138D, PRO161D, PRO235D, SER110C, SER123C, SER134D, SER163D, SER190D, SER208D, SER216C, SER224C, SER237D, SER250C, SER252C, SER254C, SER256C, SER292D, SER308C, SER53D, SER80C, SER82C, SER9C, THR103C, THR137D, THR155D, THR167D, THR236D, THR255C, THR273C, THR314C, THR33C, TRP267D, TRP29C, TRP98C, TYR153D, TYR165D, TYR18C, TYR288D, TYR5C, VAL107C, VAL140D, VAL156D, VAL171D, VAL185D, VAL187D, VAL194D, VAL243C, VAL293D, VAL315C, VAL67D, VAL81C, VAL83C
• C-J: ALA311C, ALA311J, GLY309C, GLY309J, ILE312C, ILE312J, VAL315C, VAL315J
• C-K: ALA307C, ASN133C, ASN133K, ASN318C, ASN318K, ASP262C, ASP262K, ASP264C, ASP264K, ASP319C, ASP319K, GLN268C, GLN268K, GLN285C, GLN285K, GLN306C, GLN306K, GLU266C, GLU266K, GLY132C, GLY132K, HIS282C, HIS282K, ILE259C, ILE259K, ILE312C, ILE312K, ILE316C, ILE316K, LEU284C, LEU284K, LYS131C, LYS131K, SER260C, SER260K, SER308C, SER308K, THR261C, THR261K, THR281C, THR281K, THR283C, THR283K, TRP267C, TRP267K, VAL263C, VAL263K, VAL269C, VAL269K, VAL315C, VAL315K
• D-E: ALA11D, ALA122D, ALA142E, ALA146E, ALA154E, ALA15D, ALA16D, ALA177E, ALA179E, ALA19D, ALA20D, ALA211E, ALA220D, ALA222D, ALA223D, ALA249D, ALA48D, ALA56D, ALA63E, ALA76D, ALA7D, ARG14D, ARG157E, ARG178E, ARG184E, ARG209D, ARG209E, ARG225D, ARG251D, ARG272D, ARG279D, ARG65E, ARG96D, ASN166E, ASN170E, ASN193E, ASN234E, ASN238E, ASN253D, ASN62E, ASP101D, ASP151E, ASP168E, ASP174E, ASP175E, ASP189E, ASP213D, ASP217D, ASP239E, ASP6D, ASP78D, CYS109D, GLN17D, GLN182E, GLN278D, GLN64E, GLN93D, GLU105D, GLU145E, GLU160E, GLU244D, GLU248D, GLU275D, GLU290E, GLU52E, GLU77D, GLY104D, GLY108D, GLY124D, GLY135E, GLY144E, GLY148E, GLY149E, GLY159E, GLY164E, GLY219D, GLY226D, GLY274D, GLY276D, GLY79D, GLY94D, GLY97D, HIS141E, HIS183E, HIS22D, HIS291E, HIS3D, HIS95D, ILE176E, ILE186E, ILE207E, ILE218D, ILE242E, ILE2D, LEU102D, LEU106D, LEU139E, LEU13D, LEU162E, LEU214D, LEU215D, LEU245D, LEU277D, LEU294E, LEU4D, LEU99D, LYS12D, LYS131E, LYS136E, LYS150E, LYS152E, LYS192E, LYS241E, LYS247D, LYS75D, LYS8D, LYS92D, MET125D, MET180E, MET1D, MET221D, MET91D, PHE10D, PHE158E, PHE169E, PHE172E, PHE212D, PHE59E, PHE90E, PRO111D, PRO138E, PRO161E, PRO235E, SER110D, SER123D, SER163E, SER190E, SER208E, SER216D, SER224D, SER237E, SER250D, SER252D, SER254D, SER256D, SER292E, SER53E, SER80D, SER82D, SER9D, THR103D, THR137E, THR155E, THR167E, THR236E, THR23D, THR255D, THR273D, THR33D, TRP29D, TRP98D, TYR153E, TYR165E, TYR18D, TYR288E, TYR5D, VAL107D, VAL126D, VAL140E, VAL156E, VAL171E, VAL185E, VAL187E, VAL194E, VAL293E, VAL67E, VAL81D, VAL83D
• D-J: ASN133D, ASN318J, ASP262D, ASP262J, ASP264D, ASP264J, ASP319J, GLN268D, GLN268J, GLN285D, GLN285J, GLN306J, GLU266D, GLU266J, GLY132D, HIS282D, HIS282J, ILE259D, ILE259J, ILE312J, ILE316J, LEU284D, LEU284J, LEU321J, LYS131D, LYS241D, SER260D, SER260J, THR261D, THR261J, THR281D, THR281J, THR283D, THR283J, TRP267D, TRP267J, VAL263D, VAL263J, VAL269D, VAL269J, VAL315J
• E-F: ALA11E, ALA122E, ALA142F, ALA146F, ALA154F, ALA15E, ALA16E, ALA177F, ALA179F, ALA19E, ALA20E, ALA220E, ALA222E, ALA223E, ALA249E, ALA311E, ALA48E, ALA56E, ALA63F, ALA76E, ALA7E, ARG14E, ARG157F, ARG178F, ARG184F, ARG209E, ARG209F, ARG225E, ARG251E, ARG272E, ARG279E, ARG65F, ARG96E, ASN133F, ASN166F, ASN170F, ASN193F, ASN234F, ASN238F, ASN253E, ASN62F, ASN88F, ASP101E, ASP151F, ASP168F, ASP174F, ASP175F, ASP189F, ASP213E, ASP217E, ASP239F, ASP240E, ASP240F, ASP6E, ASP78E, CYS109E, GLN17E, GLN182F, GLN278E, GLN313E, GLN64F, GLN93E, GLU105E, GLU145F, GLU160F, GLU244E, GLU248E, GLU275E, GLU290F, GLU52F, GLU71E, GLU77E, GLY104E, GLY108E, GLY124E, GLY130F, GLY132F, GLY135F, GLY144F, GLY148F, GLY149F, GLY159F, GLY164F, GLY219E, GLY226E, GLY274E, GLY276E, GLY309E, GLY79E, GLY94E, GLY97E, HIS141F, HIS183F, HIS22E, HIS291F, HIS3E, HIS95E, ILE176F, ILE186F, ILE207F, ILE218E, ILE242F, ILE2E, ILE312E, LEU102E, LEU106E, LEU139F, LEU13E, LEU162F, LEU181F, LEU214E, LEU215E, LEU245E, LEU277E, LEU294F, LEU321E, LEU4E, LEU99E, LYS12E, LYS131F, LYS136F, LYS150F, LYS152F, LYS192F, LYS241E, LYS241F, LYS247E, LYS310E, LYS317E, LYS75E, LYS8E, LYS92E, MET125E, MET180F, MET1E, MET221E, MET91E, PHE10E, PHE158F, PHE169F, PHE172F, PHE212E, PHE59F, PHE90F, PRO111E, PRO138F, PRO161F, PRO235F, SER110E, SER123E, SER134F, SER163F, SER190F, SER208F, SER216E, SER224E, SER237F, SER250E, SER252E, SER254E, SER256E, SER292F, SER308E, SER53F, SER80E, SER82E, SER9E, THR103E, THR137F, THR155F, THR167F, THR236F, THR23E, THR255E, THR273E, THR314E, THR33E, TRP267F, TRP29E, TRP98E, TYR153F, TYR165F, TYR18E, TYR288F, TYR5E, VAL107E, VAL140F, VAL156F, VAL171F, VAL185F, VAL187F, VAL194F, VAL243F, VAL293F, VAL67F, VAL81E, VAL83E
• E-I: ASN133I, ASN318E, ASP262E, ASP262I, ASP264E, ASP264I, ASP319E, GLN268E, GLN268I, GLN285E, GLN285I, GLN306E, GLU266E, GLU266I, GLY132I, HIS282E, HIS282I, ILE259E, ILE259I, ILE312E, ILE316E, LEU284E, LEU284I, LEU321E, LYS131I, LYS241I, SER260E, SER260I, THR261E, THR261I, THR281E, THR281I, THR283E, THR283I, TRP267E, TRP267I, VAL263E, VAL263I, VAL269E, VAL269I, VAL315E
• F-G: ALA311F, ALA311G, GLY309F, GLY309G, ILE312F, ILE312G, VAL315F, VAL315G
• F-H: ASN133H, ASN318F, ASP262F, ASP262H, ASP264F, ASP264H, ASP319F, GLN268F, GLN268H, GLN285F, GLN285H, GLN306F, GLU266F, GLU266H, GLY132H, HIS282F, HIS282H, ILE259F, ILE259H, ILE312F, ILE316F, LEU284F, LEU284H, LEU321F, LYS131H, LYS241H, SER260F, SER260H, THR261F, THR261H, THR281F, THR281H, THR283F, THR283H, TRP267F, TRP267H, VAL263F, VAL263H, VAL269F, VAL315F
• G-H: ALA11G, ALA122G, ALA142H, ALA146H, ALA154H, ALA15G, ALA16G, ALA177H, ALA179H, ALA19G, ALA20G, ALA220G, ALA222G, ALA223G, ALA249G, ALA311G, ALA56G, ALA63H, ALA76G, ALA7G, ARG14G, ARG157H, ARG178H, ARG184H, ARG209G, ARG209H, ARG225G, ARG251G, ARG272G, ARG279G, ARG65H, ARG96G, ASN133H, ASN166H, ASN170H, ASN193H, ASN234H, ASN238H, ASN253G, ASN318G, ASN62H, ASP101G, ASP151H, ASP168H, ASP174H, ASP175H, ASP189H, ASP213G, ASP217G, ASP239H, ASP240G, ASP240H, ASP6G, ASP78G, CYS109G, GLN17G, GLN182H, GLN278G, GLN313G, GLN64H, GLN93G, GLU105G, GLU145H, GLU160H, GLU244G, GLU248G, GLU275G, GLU290H, GLU52H, GLU71G, GLU77G, GLY104G, GLY108G, GLY124G, GLY130H, GLY132H, GLY135H, GLY144H, GLY148H, GLY149H, GLY159H, GLY164H, GLY219G, GLY226G, GLY274G, GLY276G, GLY309G, GLY79G, GLY94G, GLY97G, HIS141H, HIS183H, HIS22G, HIS291H, HIS3G, HIS95G, ILE176H, ILE186H, ILE207H, ILE218G, ILE2G, ILE312G, LEU102G, LEU106G, LEU139H, LEU13G, LEU162H, LEU215G, LEU245G, LEU277G, LEU294H, LEU321G, LEU4G, LEU99G, LYS12G, LYS131H, LYS136H, LYS150H, LYS152H, LYS192H, LYS247G, LYS310G, LYS317G, LYS75G, LYS8G, MET125G, MET180H, MET1G, MET221G, MET91G, PHE10G, PHE158H, PHE169H, PHE172H, PHE212G, PHE59H, PHE90H, PRO111G, PRO138H, PRO161H, PRO235H, SER110G, SER123G, SER134H, SER163H, SER190H, SER208H, SER216G, SER224G, SER237H, SER250G, SER252G, SER254G, SER256G, SER292H, SER308G, SER53H, SER80G, SER82G, SER9G, THR103G, THR137H, THR155H, THR167H, THR236H, THR23G, THR255G, THR273G, THR314G, THR33G, TRP267H, TRP29G, TRP98G, TYR153H, TYR165H, TYR18G, TYR288H, TYR5G, VAL107G, VAL140H, VAL156H, VAL171H, VAL185H, VAL187H, VAL194H, VAL293H, VAL315G, VAL67H, VAL81G, VAL83G
• G-L: ALA11L, ALA122L, ALA142G, ALA146G, ALA154G, ALA15L, ALA16L, ALA177G, ALA179G, ALA19L, ALA20L, ALA211G, ALA220L, ALA222L, ALA223L, ALA249L, ALA48L, ALA56L, ALA63G, ALA76L, ALA7L, ARG14L, ARG157G, ARG178G, ARG209G, ARG209L, ARG225L, ARG251L, ARG272L, ARG279L, ARG65G, ARG96L, ASN133G, ASN166G, ASN170G, ASN193G, ASN234G, ASN238G, ASN253L, ASN62G, ASP101L, ASP151G, ASP168G, ASP174G, ASP175G, ASP189G, ASP213L, ASP217L, ASP239G, ASP6L, ASP78L, CYS109L, GLN17L, GLN182G, GLN278L, GLN64G, GLN93L, GLU105L, GLU145G, GLU160G, GLU244L, GLU248L, GLU275L, GLU290G, GLU52G, GLU77L, GLY104L, GLY108L, GLY124L, GLY135G, GLY144G, GLY148G, GLY149G, GLY159G, GLY164G, GLY219L, GLY226L, GLY274L, GLY276L, GLY79L, GLY94L, GLY97L, HIS141G, HIS183G, HIS22L, HIS291G, HIS3L, HIS95L, ILE176G, ILE186G, ILE207G, ILE218L, ILE242G, ILE2L, LEU102L, LEU106L, LEU139G, LEU13L, LEU162G, LEU214L, LEU215L, LEU245L, LEU277L, LEU294G, LEU4L, LEU99L, LYS12L, LYS131G, LYS136G, LYS150G, LYS152G, LYS192G, LYS247L, LYS75L, LYS8L, LYS92L, MET125L, MET180G, MET1L, MET221L, MET91L, PHE10L, PHE158G, PHE169G, PHE172G, PHE212L, PHE59G, PHE90G, PRO111L, PRO138G, PRO161G, PRO235G, SER110L, SER123L, SER163G, SER190G, SER208G, SER216L, SER224L, SER237G, SER250L, SER252L, SER254L, SER256L, SER292G, SER53G, SER80L, SER82L, SER9L, THR103L, THR137G, THR155G, THR167G, THR236G, THR23L, THR255L, THR273L, THR33L, TRP29L, TRP98L, TYR153G, TYR165G, TYR18L, TYR288G, TYR5L, VAL107L, VAL126L, VAL140G, VAL156G, VAL171G, VAL185G, VAL187G, VAL194G, VAL293G, VAL67G, VAL81L, VAL83L
• H-I: ALA11H, ALA122H, ALA142I, ALA146I, ALA154I, ALA15H, ALA16H, ALA177I, ALA179I, ALA19H, ALA20H, ALA220H, ALA222H, ALA223H, ALA249H, ALA48H, ALA56H, ALA63I, ALA76H, ALA7H, ARG14H, ARG157I, ARG178I, ARG184I, ARG209H, ARG209I, ARG225H, ARG251H, ARG272H, ARG279H, ARG65I, ARG96H, ASN133I, ASN166I, ASN170I, ASN193I, ASN234I, ASN238I, ASN253H, ASN62I, ASN88I, ASP101H, ASP151I, ASP168I, ASP174I, ASP175I, ASP189I, ASP213H, ASP217H, ASP239I, ASP240I, ASP6H, ASP78H, CYS109H, GLN17H, GLN182I, GLN278H, GLN64I, GLN93H, GLU105H, GLU145I, GLU160I, GLU244H, GLU248H, GLU275H, GLU290I, GLU52I, GLU71H, GLU77H, GLY104H, GLY108H, GLY124H, GLY135I, GLY144I, GLY148I, GLY149I, GLY159I, GLY164I, GLY219H, GLY226H, GLY274H, GLY276H, GLY79H, GLY89I, GLY94H, GLY97H, HIS141I, HIS183I, HIS22H, HIS291I, HIS3H, HIS95H, ILE176I, ILE186I, ILE207I, ILE218H, ILE2H, LEU102H, LEU106H, LEU139I, LEU13H, LEU162I, LEU181I, LEU214H, LEU215H, LEU245H, LEU277H, LEU294I, LEU4H, LEU99H, LYS12H, LYS131I, LYS136I, LYS150I, LYS152I, LYS192I, LYS247H, LYS75H, LYS8H, LYS92H, MET125H, MET180I, MET1H, MET221H, MET91H, PHE10H, PHE158I, PHE169I, PHE172I, PHE212H, PHE59I, PHE90I, PRO111H, PRO138I, PRO161I, PRO235I, SER110H, SER123H, SER163I, SER190I, SER208I, SER216H, SER224H, SER237I, SER250H, SER252H, SER254H, SER256H, SER292I, SER53I, SER80H, SER82H, SER9H, THR103H, THR137I, THR155I, THR167I, THR236I, THR255H, THR273H, THR33H, TRP29H, TRP98H, TYR153I, TYR165I, TYR18H, TYR288I, TYR5H, VAL107H, VAL140I, VAL156I, VAL171I, VAL185I, VAL187I, VAL194I, VAL293I, VAL67I, VAL81H, VAL83H
• H-S: GLU290S, GLU71H, HIS291S, LYS70H, LYS72H
• H-X: GLU41H, LYS8X
• I-J: ALA11I, ALA122I, ALA142J, ALA146J, ALA154J, ALA15I, ALA16I, ALA177J, ALA179J, ALA19I, ALA20I, ALA211J, ALA220I, ALA222I, ALA223I, ALA249I, ALA48I, ALA56I, ALA63J, ALA76I, ALA7I, ARG14I, ARG157J, ARG178J, ARG184J, ARG209I, ARG209J, ARG225I, ARG251I, ARG272I, ARG279I, ARG65J, ARG96I, ASN166J, ASN170J, ASN193J, ASN234J, ASN238J, ASN253I, ASN62J, ASP101I, ASP151J, ASP168J, ASP174J, ASP175J, ASP189J, ASP213I, ASP217I, ASP239J, ASP6I, ASP78I, CYS109I, GLN17I, GLN182J, GLN278I, GLN64J, GLN93I, GLU105I, GLU145J, GLU160J, GLU244I, GLU248I, GLU275I, GLU290J, GLU52J, GLU71I, GLU77I, GLY104I, GLY108I, GLY124I, GLY135J, GLY144J, GLY148J, GLY149J, GLY159J, GLY164J, GLY219I, GLY226I, GLY274I, GLY276I, GLY79I, GLY94I, GLY97I, HIS141J, HIS183J, HIS22I, HIS291J, HIS3I, HIS95I, ILE176J, ILE186J, ILE188J, ILE207J, ILE218I, ILE242J, ILE2I, LEU102I, LEU106I, LEU139J, LEU13I, LEU162J, LEU214I, LEU215I, LEU245I, LEU277I, LEU294J, LEU4I, LEU99I, LYS12I, LYS131J, LYS136J, LYS150J, LYS152J, LYS192J, LYS247I, LYS75I, LYS8I, LYS92I, MET125I, MET180J, MET1I, MET221I, MET91I, PHE10I, PHE158J, PHE169J, PHE172J, PHE212I, PHE59J, PHE90J, PRO111I, PRO138J, PRO161J, PRO235J, SER110I, SER123I, SER163J, SER190J, SER208J, SER216I, SER224I, SER237J, SER250I, SER252I, SER254I, SER256I, SER292J, SER53J, SER80I, SER82I, SER9I, THR103I, THR137J, THR155J, THR167J, THR236J, THR255I, THR273I, THR33I, TRP29I, TRP98I, TYR153J, TYR165J, TYR18I, TYR288J, TYR5I, VAL107I, VAL140J, VAL156J, VAL171J, VAL185J, VAL187J, VAL194J, VAL293J, VAL67J, VAL81I, VAL83I
• I-M: ALA114M, ALA15M, ALA19M, ALA25M, ARG120M, ASN62I, ASP101I, ASP24M, ASP31I, ASP42I, GLU115M, GLU38I, GLU41I, GLY117M, GLY118M, GLY35I, HIS119M, HIS22M, HIS32I, LEU280M, LEU37I, LYS12M, LYS150M, LYS61I, LYS72I, LYS75I, PHE116M, PHE21M, PRO26M, SER28I, SER299M, SER34I, SER39I, SER73I, THR23M, THR273M, THR44I, TYR18M, TYR69I, VAL100I, VAL112M, VAL36I, VAL40I, VAL74I
• I-N: GLU290N, GLU71I, GLY289N, HIS291N, LYS70I, LYS72I, SER73I, VAL74I
• J-K: ALA11J, ALA122J, ALA142K, ALA146K, ALA154K, ALA15J, ALA16J, ALA177K, ALA179K, ALA19J, ALA20J, ALA220J, ALA222J, ALA223J, ALA249J, ALA311J, ALA48J, ALA56J, ALA63K, ALA76J, ALA7J, ARG14J, ARG157K, ARG178K, ARG184K, ARG209J, ARG209K, ARG225J, ARG251J, ARG272J, ARG279J, ARG65K, ARG96J, ASN133K, ASN166K, ASN170K, ASN193K, ASN234K, ASN238K, ASN253J, ASN62K, ASN88K, ASP101J, ASP151K, ASP168K, ASP174K, ASP175K, ASP189K, ASP213J, ASP217J, ASP239K, ASP240J, ASP240K, ASP6J, ASP78J, CYS109J, GLN17J, GLN182K, GLN278J, GLN313J, GLN64K, GLN93J, GLU105J, GLU145K, GLU160K, GLU244J, GLU248J, GLU275J, GLU290K, GLU52K, GLU71J, GLU77J, GLY104J, GLY108J, GLY124J, GLY130K, GLY132K, GLY135K, GLY144K, GLY148K, GLY149K, GLY159K, GLY164K, GLY219J, GLY226J, GLY274J, GLY276J, GLY309J, GLY79J, GLY94J, GLY97J, HIS141K, HIS183K, HIS22J, HIS291K, HIS3J, HIS95J, ILE176K, ILE186K, ILE188K, ILE207K, ILE218J, ILE242K, ILE2J, ILE312J, LEU102J, LEU106J, LEU139K, LEU13J, LEU162K, LEU215J, LEU245J, LEU277J, LEU294K, LEU321J, LEU4J, LEU99J, LYS12J, LYS131K, LYS136K, LYS150K, LYS152K, LYS192K, LYS241J, LYS241K, LYS247J, LYS310J, LYS317J, LYS75J, LYS8J, MET125J, MET180K, MET1J, MET221J, MET91J, PHE10J, PHE158K, PHE169K, PHE172K, PHE212J, PHE59K, PHE90K, PRO111J, PRO138K, PRO161K, PRO235K, SER110J, SER123J, SER134K, SER163K, SER190K, SER208K, SER216J, SER224J, SER237K, SER250J, SER252J, SER254J, SER256J, SER292K, SER308J, SER53K, SER80J, SER82J, SER9J, THR103J, THR137K, THR155K, THR167K, THR236K, THR23J, THR255J, THR273J, THR314J, THR33J, TRP267K, TRP29J, TRP98J, TYR153K, TYR165K, TYR18J, TYR288K, TYR5J, VAL107J, VAL140K, VAL156K, VAL171K, VAL185K, VAL187K, VAL194K, VAL243K, VAL293K, VAL67K, VAL81J, VAL83J
• J-M: GLN64J, LYS12M
• K-L: ALA11K, ALA122K, ALA142L, ALA146L, ALA154L, ALA15K, ALA16K, ALA177L, ALA179L, ALA19K, ALA20K, ALA220K, ALA222K, ALA223K, ALA249K, ALA311K, ALA48K, ALA56K, ALA63L, ALA76K, ALA7K, ARG14K, ARG157L, ARG178L, ARG184L, ARG209K, ARG209L, ARG225K, ARG251K, ARG272K, ARG279K, ARG65L, ARG96K, ASN133L, ASN166L, ASN170L, ASN193L, ASN234L, ASN238L, ASN253K, ASN318K, ASN62L, ASN88L, ASP101K, ASP151L, ASP168L, ASP174L, ASP175L, ASP189L, ASP213K, ASP217K, ASP239L, ASP240K, ASP240L, ASP264L, ASP6K, ASP78K, CYS109K, GLN17K, GLN182L, GLN278K, GLN313K, GLN64L, GLN93K, GLU105K, GLU145L, GLU160L, GLU244K, GLU248K, GLU275K, GLU290L, GLU52L, GLU71K, GLU77K, GLY104K, GLY108K, GLY124K, GLY130L, GLY132L, GLY135L, GLY144L, GLY148L, GLY149L, GLY159L, GLY164L, GLY219K, GLY226K, GLY274K, GLY276K, GLY309K, GLY79K, GLY94K, GLY97K, HIS141L, HIS183L, HIS22K, HIS291L, HIS3K, HIS95K, ILE176L, ILE186L, ILE207L, ILE218K, ILE242L, ILE2K, ILE312K, LEU102K, LEU106K, LEU139L, LEU13K, LEU162L, LEU181L, LEU215K, LEU245K, LEU277K, LEU294L, LEU321K, LEU4K, LEU99K, LYS12K, LYS131L, LYS136L, LYS150L, LYS152L, LYS192L, LYS241K, LYS247K, LYS310K, LYS317K, LYS75K, LYS8K, LYS92K, MET125K, MET180L, MET1K, MET221K, MET91K, PHE10K, PHE158L, PHE169L, PHE172L, PHE212K, PHE59L, PHE90L, PRO111K, PRO138L, PRO161L, PRO235L, SER110K, SER123K, SER134L, SER163L, SER190L, SER208L, SER216K, SER224K, SER237L, SER250K, SER252K, SER254K, SER256K, SER260L, SER292L, SER308K, SER53L, SER80K, SER82K, SER9K, THR103K, THR137L, THR155L, THR167L, THR236L, THR23K, THR255K, THR273K, THR314K, THR33K, TRP267L, TRP29K, TRP98K, TYR153L, TYR165L, TYR18K, TYR288L, TYR5K, VAL107K, VAL140L, VAL156L, VAL171L, VAL185L, VAL187L, VAL194L, VAL243K, VAL293L, VAL315K, VAL67L, VAL81K, VAL83K
• M-N: ALA11M, ALA122M, ALA142N, ALA146N, ALA154N, ALA15M, ALA16M, ALA177N, ALA179N, ALA19M, ALA20M, ALA220M, ALA222M, ALA223M, ALA249M, ALA311M, ALA48M, ALA56M, ALA63N, ALA76M, ALA7M, ARG14M, ARG157N, ARG178N, ARG184N, ARG209M, ARG209N, ARG225M, ARG251M, ARG272M, ARG279M, ARG65N, ARG96M, ASN133N, ASN166N, ASN170N, ASN193N, ASN234N, ASN238N, ASN253M, ASN318M, ASN62N, ASP101M, ASP151N, ASP168N, ASP174N, ASP175N, ASP189N, ASP213M, ASP217M, ASP239N, ASP240M, ASP240N, ASP6M, ASP78M, CYS109M, GLN17M, GLN182N, GLN278M, GLN313M, GLN64N, GLN93M, GLU105M, GLU145N, GLU160N, GLU244M, GLU248M, GLU275M, GLU290N, GLU52N, GLU71M, GLU77M, GLY104M, GLY108M, GLY124M, GLY130N, GLY132N, GLY135N, GLY144N, GLY148N, GLY149N, GLY159N, GLY164N, GLY219M, GLY226M, GLY274M, GLY276M, GLY309M, GLY79M, GLY94M, GLY97M, HIS141N, HIS183N, HIS22M, HIS291N, HIS3M, HIS95M, ILE176N, ILE186N, ILE207N, ILE218M, ILE242N, ILE2M, ILE312M, LEU102M, LEU106M, LEU139N, LEU13M, LEU162N, LEU215M, LEU245M, LEU277M, LEU294N, LEU321M, LEU4M, LEU99M, LYS12M, LYS131N, LYS136N, LYS150N, LYS152N, LYS192N, LYS241M, LYS241N, LYS247M, LYS310M, LYS317M, LYS75M, LYS8M, MET125M, MET180N, MET1M, MET221M, MET91M, PHE10M, PHE158N, PHE169N, PHE172N, PHE212M, PHE59N, PHE90N, PRO111M, PRO138N, PRO161N, PRO235N, SER110M, SER123M, SER134N, SER163N, SER190N, SER208N, SER216M, SER224M, SER237N, SER250M, SER252M, SER254M, SER256M, SER292N, SER308M, SER53N, SER80M, SER82M, SER9M, THR103M, THR137N, THR155N, THR167N, THR236N, THR23M, THR255M, THR273M, THR295N, THR314M, THR33M, TRP267N, TRP29M, TRP98M, TYR153N, TYR165N, TYR18M, TYR288N, TYR5M, VAL107M, VAL140N, VAL156N, VAL171N, VAL185N, VAL187N, VAL194N, VAL243N, VAL293N, VAL67N, VAL81M, VAL83M
• M-R: ALA11R, ALA122R, ALA142M, ALA146M, ALA154M, ALA15R, ALA16R, ALA177M, ALA179M, ALA19R, ALA20R, ALA220R, ALA222R, ALA223R, ALA249R, ALA311R, ALA48R, ALA56R, ALA63M, ALA76R, ALA7R, ARG14R, ARG157M, ARG178M, ARG209M, ARG209R, ARG225R, ARG251R, ARG272R, ARG279R, ARG65M, ARG96R, ASN133M, ASN166M, ASN170M, ASN193M, ASN234M, ASN238M, ASN253R, ASN62M, ASN88M, ASP101R, ASP151M, ASP168M, ASP174M, ASP175M, ASP189M, ASP213R, ASP217R, ASP239M, ASP240M, ASP240R, ASP6R, ASP78R, CYS109R, GLN17R, GLN182M, GLN278R, GLN313R, GLN64M, GLN93R, GLU105R, GLU145M, GLU160M, GLU244R, GLU248R, GLU275R, GLU290M, GLU52M, GLU71R, GLU77R, GLY104R, GLY108R, GLY124R, GLY130M, GLY132M, GLY135M, GLY144M, GLY148M, GLY149M, GLY159M, GLY164M, GLY219R, GLY226R, GLY274R, GLY276R, GLY309R, GLY79R, GLY94R, GLY97R, HIS141M, HIS183M, HIS22R, HIS291M, HIS3R, HIS95R, ILE176M, ILE186M, ILE207M, ILE218R, ILE242M, ILE2R, ILE312R, LEU102R, LEU106R, LEU139M, LEU13R, LEU162M, LEU215R, LEU245R, LEU277R, LEU294M, LEU321R, LEU4R, LEU99R, LYS12R, LYS131M, LYS136M, LYS150M, LYS152M, LYS192M, LYS241M, LYS241R, LYS247R, LYS310R, LYS317R, LYS75R, LYS8R, MET125R, MET180M, MET1R, MET221R, MET91R, PHE10R, PHE158M, PHE169M, PHE172M, PHE212R, PHE59M, PHE90M, PRO111R, PRO138M, PRO161M, PRO235M, SER110R, SER123R, SER134M, SER163M, SER190M, SER208M, SER216R, SER224R, SER237M, SER250R, SER252R, SER254R, SER256R, SER292M, SER308R, SER53M, SER80R, SER82R, SER9R, THR103R, THR137M, THR155M, THR167M, THR236M, THR255R, THR273R, THR314R, THR33R, TRP267M, TRP29R, TRP98R, TYR153M, TYR165M, TYR18R, TYR288M, TYR5R, VAL107R, VAL140M, VAL156M, VAL171M, VAL185M, VAL187M, VAL194M, VAL243M, VAL293M, VAL67M, VAL81R, VAL83R
• M-S: ALA307M, ALA307S, ASN133M, ASN133S, ASN318M, ASN318S, ASP262M, ASP262S, ASP264M, ASP264S, ASP319M, ASP319S, GLN268M, GLN268S, GLN285M, GLN285S, GLN306M, GLN306S, GLU266M, GLU266S, GLY132M, GLY132S, GLY309M, GLY309S, HIS282M, HIS282S, ILE259M, ILE259S, ILE312M, ILE312S, ILE316M, ILE316S, LEU284M, LEU284S, LYS131M, LYS131S, SER260M, SER260S, SER308M, SER308S, THR261M, THR261S, THR281M, THR281S, THR283M, THR283S, TRP267M, TRP267S, VAL263M, VAL263S, VAL269M, VAL269S, VAL315M, VAL315S
• N-O: ALA11N, ALA122N, ALA142O, ALA146O, ALA154O, ALA15N, ALA16N, ALA177O, ALA179O, ALA19N, ALA20N, ALA220N, ALA222N, ALA223N, ALA249N, ALA311N, ALA48N, ALA56N, ALA63O, ALA76N, ALA7N, ARG14N, ARG157O, ARG178O, ARG184O, ARG209N, ARG209O, ARG225N, ARG251N, ARG272N, ARG279N, ARG65O, ARG96N, ASN133O, ASN166O, ASN170O, ASN193O, ASN234O, ASN238O, ASN253N, ASN318N, ASN62O, ASN88O, ASP101N, ASP151O, ASP168O, ASP174O, ASP175O, ASP189O, ASP213N, ASP217N, ASP239O, ASP240N, ASP240O, ASP6N, ASP78N, CYS109N, GLN17N, GLN182O, GLN278N, GLN313N, GLN64O, GLN93N, GLU105N, GLU145O, GLU160O, GLU244N, GLU248N, GLU275N, GLU290O, GLU52O, GLU71N, GLU77N, GLY104N, GLY108N, GLY124N, GLY130O, GLY132O, GLY135O, GLY144O, GLY148O, GLY149O, GLY159O, GLY164O, GLY219N, GLY226N, GLY274N, GLY276N, GLY309N, GLY79N, GLY94N, GLY97N, HIS141O, HIS183O, HIS22N, HIS291O, HIS3N, HIS95N, ILE176O, ILE186O, ILE207O, ILE218N, ILE242O, ILE2N, ILE312N, LEU102N, LEU106N, LEU139O, LEU13N, LEU162O, LEU215N, LEU245N, LEU277N, LEU294O, LEU321N, LEU4N, LEU99N, LYS12N, LYS131O, LYS136O, LYS150O, LYS152O, LYS192O, LYS241N, LYS241O, LYS247N, LYS310N, LYS317N, LYS75N, LYS8N, MET125N, MET180O, MET1N, MET221N, MET91N, PHE10N, PHE158O, PHE169O, PHE172O, PHE212N, PHE59O, PHE90O, PRO111N, PRO138O, PRO161O, PRO235O, SER110N, SER123N, SER134O, SER163O, SER190O, SER208O, SER216N, SER224N, SER237O, SER250N, SER252N, SER254N, SER256N, SER260O, SER292O, SER308N, SER53O, SER80N, SER82N, SER9N, THR103N, THR137O, THR155O, THR167O, THR236O, THR23N, THR255N, THR273N, THR314N, THR33N, TRP267O, TRP29N, TRP98N, TYR153O, TYR165O, TYR18N, TYR288O, TYR5N, VAL107N, VAL140O, VAL156O, VAL171O, VAL185O, VAL187O, VAL194O, VAL243O, VAL293O, VAL67O, VAL81N, VAL83N
• N-X: ASP262N, ASP262X, ASP319N, GLU266N, GLU266X
• O-P: ALA11O, ALA122O, ALA142P, ALA146P, ALA154P, ALA15O, ALA16O, ALA177P, ALA179P, ALA19O, ALA20O, ALA220O, ALA222O, ALA223O, ALA249O, ALA311O, ALA48O, ALA56O, ALA63P, ALA76O, ALA7O, ARG14O, ARG157P, ARG178P, ARG184P, ARG209O, ARG209P, ARG225O, ARG251O, ARG272O, ARG279O, ARG65P, ARG96O, ASN133P, ASN166P, ASN170P, ASN193P, ASN234P, ASN238P, ASN253O, ASN62P, ASN88P, ASP101O, ASP151P, ASP168P, ASP174P, ASP175P, ASP189P, ASP213O, ASP217O, ASP239P, ASP240O, ASP240P, ASP6O, ASP78O, CYS109O, GLN17O, GLN182P, GLN278O, GLN313O, GLN64P, GLN93O, GLU105O, GLU145P, GLU160P, GLU244O, GLU248O, GLU275O, GLU290P, GLU52P, GLU71O, GLU77O, GLY104O, GLY108O, GLY124O, GLY130P, GLY132P, GLY135P, GLY144P, GLY148P, GLY149P, GLY159P, GLY164P, GLY219O, GLY226O, GLY274O, GLY276O, GLY309O, GLY79O, GLY89P, GLY94O, GLY97O, HIS141P, HIS183P, HIS22O, HIS291P, HIS3O, HIS95O, ILE176P, ILE186P, ILE188P, ILE207P, ILE218O, ILE242P, ILE2O, ILE312O, LEU102O, LEU106O, LEU139P, LEU13O, LEU162P, LEU181P, LEU215O, LEU245O, LEU277O, LEU294P, LEU321O, LEU4O, LEU99O, LYS12O, LYS131P, LYS136P, LYS150P, LYS152P, LYS192P, LYS241O, LYS241P, LYS247O, LYS310O, LYS317O, LYS75O, LYS8O, LYS92O, MET125O, MET180P, MET1O, MET221O, MET91O, PHE10O, PHE158P, PHE169P, PHE172P, PHE212O, PHE59P, PHE90P, PRO111O, PRO138P, PRO161P, PRO235P, SER110O, SER123O, SER134P, SER163P, SER190P, SER208P, SER216O, SER224O, SER237P, SER250O, SER252O, SER254O, SER256O, SER292P, SER308O, SER53P, SER80O, SER82O, SER9O, THR103O, THR137P, THR155P, THR167P, THR236P, THR23O, THR255O, THR273O, THR314O, THR33O, TRP267P, TRP29O, TRP98O, TYR153P, TYR165P, TYR18O, TYR288P, TYR5O, VAL107O, VAL140P, VAL156P, VAL171P, VAL185P, VAL187P, VAL194P, VAL243P, VAL293P, VAL67P, VAL81O, VAL83O
• O-V: ALA311O, ALA311V, GLY309O, GLY309V, ILE312O, ILE312V, VAL315O, VAL315V
• O-W: ASP262O, ASP262W, ASP319O, ASP319W, GLU266O, GLU266W
• P-Q: ALA11P, ALA122P, ALA142Q, ALA146Q, ALA154Q, ALA15P, ALA16P, ALA177Q, ALA179Q, ALA19P, ALA20P, ALA220P, ALA222P, ALA223P, ALA249P, ALA311P, ALA48P, ALA56P, ALA63Q, ALA76P, ALA7P, ARG14P, ARG157Q, ARG178Q, ARG209P, ARG209Q, ARG225P, ARG251P, ARG272P, ARG279P, ARG65Q, ARG96P, ASN133Q, ASN166Q, ASN170Q, ASN193Q, ASN234Q, ASN238Q, ASN253P, ASN318P, ASN62Q, ASN88Q, ASP101P, ASP151Q, ASP168Q, ASP174Q, ASP175Q, ASP189Q, ASP213P, ASP217P, ASP239Q, ASP240P, ASP240Q, ASP6P, ASP78P, CYS109P, GLN17P, GLN182Q, GLN278P, GLN313P, GLN64Q, GLN93P, GLU105P, GLU145Q, GLU160Q, GLU244P, GLU248P, GLU275P, GLU290Q, GLU52Q, GLU71P, GLU77P, GLY104P, GLY108P, GLY124P, GLY130Q, GLY132Q, GLY135Q, GLY144Q, GLY148Q, GLY149Q, GLY159Q, GLY164Q, GLY219P, GLY226P, GLY274P, GLY276P, GLY309P, GLY79P, GLY94P, GLY97P, HIS141Q, HIS183Q, HIS22P, HIS291Q, HIS3P, HIS95P, ILE176Q, ILE186Q, ILE207Q, ILE218P, ILE242Q, ILE2P, ILE312P, LEU102P, LEU106P, LEU139Q, LEU13P, LEU162Q, LEU215P, LEU245P, LEU277P, LEU294Q, LEU321P, LEU4P, LEU99P, LYS12P, LYS131Q, LYS136Q, LYS150Q, LYS152Q, LYS192Q, LYS241P, LYS241Q, LYS247P, LYS310P, LYS317P, LYS75P, LYS8P, MET125P, MET180Q, MET1P, MET221P, MET91P, PHE10P, PHE158Q, PHE169Q, PHE172Q, PHE212P, PHE59Q, PHE90Q, PRO111P, PRO138Q, PRO161Q, PRO235Q, SER110P, SER123P, SER134Q, SER163Q, SER190Q, SER208Q, SER216P, SER224P, SER237Q, SER250P, SER252P, SER254P, SER256P, SER260Q, SER292Q, SER308P, SER53Q, SER80P, SER82P, SER9P, THR103P, THR137Q, THR155Q, THR167Q, THR236Q, THR23P, THR255P, THR273P, THR314P, THR33P, TRP267Q, TRP29P, TRP98P, TYR153Q, TYR165Q, TYR18P, TYR288Q, TYR5P, VAL107P, VAL140Q, VAL156Q, VAL171Q, VAL185Q, VAL187Q, VAL194Q, VAL243Q, VAL293Q, VAL67Q, VAL81P, VAL83P
• P-V: ALA307V, ASN133P, ASN133V, ASN318P, ASN318V, ASP262P, ASP262V, ASP264P, ASP264V, ASP319P, ASP319V, GLN268P, GLN268V, GLN285P, GLN285V, GLN306P, GLN306V, GLU266P, GLU266V, GLY132P, GLY132V, HIS282P, HIS282V, ILE259P, ILE259V, ILE312P, ILE312V, ILE316P, ILE316V, LEU284P, LEU284V, LYS131P, LYS131V, SER260P, SER260V, SER308V, THR261P, THR261V, THR281P, THR281V, THR283P, THR283V, TRP267P, TRP267V, VAL263P, VAL263V, VAL269P, VAL269V, VAL315P, VAL315V
• Q-R: ALA11Q, ALA122Q, ALA142R, ALA146R, ALA154R, ALA15Q, ALA16Q, ALA177R, ALA179R, ALA19Q, ALA20Q, ALA220Q, ALA222Q, ALA223Q, ALA249Q, ALA311Q, ALA48Q, ALA56Q, ALA63R, ALA76Q, ALA7Q, ARG14Q, ARG157R, ARG178R, ARG209Q, ARG209R, ARG225Q, ARG251Q, ARG272Q, ARG279Q, ARG65R, ARG96Q, ASN133R, ASN166R, ASN170R, ASN193R, ASN234R, ASN238R, ASN253Q, ASN318Q, ASN62R, ASP101Q, ASP151R, ASP168R, ASP174R, ASP175R, ASP189R, ASP213Q, ASP217Q, ASP239R, ASP240Q, ASP240R, ASP6Q, ASP78Q, CYS109Q, GLN17Q, GLN182R, GLN278Q, GLN313Q, GLN64R, GLN93Q, GLU105Q, GLU145R, GLU160R, GLU244Q, GLU248Q, GLU275Q, GLU290R, GLU52R, GLU71Q, GLU77Q, GLY104Q, GLY108Q, GLY124Q, GLY130R, GLY132R, GLY135R, GLY144R, GLY148R, GLY149R, GLY159R, GLY164R, GLY219Q, GLY226Q, GLY274Q, GLY276Q, GLY309Q, GLY79Q, GLY94Q, GLY97Q, HIS141R, HIS183R, HIS22Q, HIS291R, HIS3Q, HIS95Q, ILE176R, ILE186R, ILE207R, ILE218Q, ILE242R, ILE2Q, ILE312Q, LEU102Q, LEU106Q, LEU139R, LEU13Q, LEU162R, LEU214Q, LEU215Q, LEU245Q, LEU277Q, LEU294R, LEU321Q, LEU4Q, LEU99Q, LYS12Q, LYS131R, LYS136R, LYS150R, LYS152R, LYS192R, LYS241Q, LYS241R, LYS247Q, LYS310Q, LYS317Q, LYS75Q, LYS8Q, MET125Q, MET180R, MET1Q, MET221Q, MET91Q, PHE10Q, PHE158R, PHE169R, PHE172R, PHE212Q, PHE59R, PHE90R, PRO111Q, PRO138R, PRO161R, PRO235R, SER110Q, SER123Q, SER134R, SER163R, SER190R, SER208R, SER216Q, SER224Q, SER237R, SER250Q, SER252Q, SER254Q, SER256Q, SER292R, SER308Q, SER53R, SER80Q, SER82Q, SER9Q, THR103Q, THR137R, THR155R, THR167R, THR236R, THR23Q, THR255Q, THR273Q, THR314Q, THR33Q, TRP267R, TRP29Q, TRP98Q, TYR153R, TYR165R, TYR18Q, TYR288R, TYR5Q, VAL107Q, VAL140R, VAL156R, VAL171R, VAL185R, VAL187R, VAL194R, VAL243R, VAL293R, VAL67R, VAL81Q, VAL83Q
• Q-T: ALA311Q, ALA311T, GLY309Q, GLY309T, ILE312Q, ILE312T, VAL315Q, VAL315T
• Q-U: ASN133U, ASN318Q, ASP262Q, ASP262U, ASP264Q, ASP264U, ASP319Q, GLN268Q, GLN268U, GLN285Q, GLN285U, GLN306Q, GLU266Q, GLU266U, GLY132U, HIS282Q, HIS282U, ILE259Q, ILE259U, ILE312Q, ILE316Q, LEU284Q, LEU284U, LEU321Q, LYS131U, LYS241U, SER260Q, SER260U, THR261Q, THR261U, THR281Q, THR281U, THR283Q, THR283U, TRP267Q, TRP267U, VAL263Q, VAL263U, VAL315Q
• R-S: ALA311R, ALA311S, GLY309R, GLY309S, ILE312R, ILE312S, VAL315R, VAL315S
• R-T: ALA307R, ALA307T, ASN133R, ASN133T, ASN318R, ASN318T, ASP262R, ASP262T, ASP264R, ASP264T, ASP319R, ASP319T, GLN268R, GLN268T, GLN285R, GLN285T, GLN306R, GLN306T, GLU266R, GLU266T, GLY132R, GLY132T, GLY309R, HIS282R, HIS282T, ILE259R, ILE259T, ILE312R, ILE312T, ILE316R, ILE316T, LEU284R, LEU284T, LYS131R, LYS131T, SER260R, SER260T, SER308R, SER308T, THR261R, THR261T, THR281R, THR281T, THR283R, THR283T, TRP267R, TRP267T, VAL263R, VAL263T, VAL269R, VAL269T, VAL315R, VAL315T
• S-T: ALA11S, ALA122S, ALA142T, ALA146T, ALA154T, ALA15S, ALA16S, ALA177T, ALA179T, ALA19S, ALA20S, ALA220S, ALA222S, ALA223S, ALA249S, ALA311S, ALA48S, ALA56S, ALA63T, ALA76S, ALA7S, ARG14S, ARG157T, ARG178T, ARG184T, ARG209S, ARG209T, ARG225S, ARG251S, ARG272S, ARG279S, ARG65T, ARG96S, ASN133T, ASN166T, ASN170T, ASN193T, ASN234T, ASN238T, ASN253S, ASN62T, ASN88T, ASP101S, ASP151T, ASP168T, ASP174T, ASP175T, ASP189T, ASP213S, ASP217S, ASP239T, ASP240S, ASP240T, ASP6S, ASP78S, CYS109S, GLN17S, GLN182T, GLN278S, GLN313S, GLN64T, GLN93S, GLU105S, GLU145T, GLU160T, GLU244S, GLU248S, GLU275S, GLU290T, GLU52T, GLU71S, GLU77S, GLY104S, GLY108S, GLY124S, GLY130T, GLY132T, GLY135T, GLY144T, GLY148T, GLY149T, GLY159T, GLY164T, GLY219S, GLY226S, GLY274S, GLY276S, GLY309S, GLY79S, GLY94S, GLY97S, HIS141T, HIS183T, HIS22S, HIS291T, HIS3S, HIS95S, ILE176T, ILE186T, ILE188T, ILE207T, ILE218S, ILE242T, ILE2S, ILE312S, LEU102S, LEU106S, LEU139T, LEU13S, LEU162T, LEU181T, LEU215S, LEU245S, LEU277S, LEU294T, LEU321S, LEU4S, LEU99S, LYS12S, LYS131T, LYS136T, LYS150T, LYS152T, LYS192T, LYS241S, LYS241T, LYS247S, LYS310S, LYS317S, LYS75S, LYS8S, LYS92S, MET125S, MET180T, MET1S, MET221S, MET91S, PHE10S, PHE158T, PHE169T, PHE172T, PHE212S, PHE59T, PHE90T, PRO111S, PRO138T, PRO161T, PRO235T, SER110S, SER123S, SER134T, SER163T, SER190T, SER208T, SER216S, SER224S, SER237T, SER250S, SER252S, SER254S, SER256S, SER292T, SER308S, SER53T, SER80S, SER82S, SER9S, THR103S, THR137T, THR155T, THR167T, THR236T, THR23S, THR255S, THR273S, THR314S, THR33S, TRP267T, TRP29S, TRP98S, TYR153T, TYR165T, TYR18S, TYR288T, TYR5S, VAL107S, VAL140T, VAL156T, VAL171T, VAL185T, VAL187T, VAL194T, VAL243T, VAL293T, VAL67T, VAL81S, VAL83S
• S-X: ARG14X, ARG157S, ARG178S, ARG209X, ARG272X, ARG96X, ASP168S, ASP174S, ASP175S, ASP189S, ASP213X, ASP217X, ASP6X, ASP78X, CYS109X, GLU145S, GLU160S, GLU275X, GLU52S, GLY108X, GLY164S, HIS141S, HIS291S, HIS3X, HIS95X, LYS152S, PRO161S, SER163S, SER224X, THR155S, THR255X, TYR5X
• T-U: ALA11T, ALA122T, ALA142U, ALA154U, ALA15T, ALA16T, ALA177U, ALA179U, ALA19T, ALA20T, ALA220T, ALA222T, ALA223T, ALA249T, ALA311T, ALA48T, ALA56T, ALA63U, ALA76T, ALA7T, ARG14T, ARG157U, ARG178U, ARG184U, ARG209T, ARG209U, ARG225T, ARG251T, ARG272T, ARG279T, ARG65U, ARG96T, ASN133U, ASN166U, ASN170U, ASN193U, ASN234U, ASN238U, ASN253T, ASN318T, ASN62U, ASN88U, ASP101T, ASP151U, ASP168U, ASP174U, ASP175U, ASP189U, ASP213T, ASP217T, ASP239U, ASP240T, ASP240U, ASP264U, ASP6T, ASP78T, CYS109T, GLN17T, GLN182U, GLN278T, GLN313T, GLN64U, GLN93T, GLU105T, GLU145U, GLU160U, GLU244T, GLU248T, GLU275T, GLU290U, GLU52U, GLU71T, GLU77T, GLY104T, GLY108T, GLY124T, GLY130U, GLY132U, GLY135U, GLY144U, GLY148U, GLY149U, GLY159U, GLY164U, GLY219T, GLY226T, GLY274T, GLY276T, GLY309T, GLY79T, GLY89U, GLY94T, GLY97T, HIS141U, HIS183U, HIS22T, HIS291U, HIS3T, HIS95T, ILE176U, ILE186U, ILE207U, ILE218T, ILE242U, ILE2T, ILE312T, LEU102T, LEU106T, LEU139U, LEU13T, LEU162U, LEU214T, LEU215T, LEU245T, LEU277T, LEU294U, LEU321T, LEU4T, LEU99T, LYS12T, LYS131U, LYS136U, LYS150U, LYS152U, LYS192U, LYS241T, LYS247T, LYS310T, LYS317T, LYS75T, LYS8T, LYS92T, MET125T, MET180U, MET1T, MET221T, MET91T, PHE10T, PHE158U, PHE169U, PHE172U, PHE212T, PHE59U, PHE90U, PRO111T, PRO138U, PRO161U, PRO235U, SER110T, SER123T, SER134U, SER163U, SER190U, SER208U, SER216T, SER224T, SER237U, SER250T, SER252T, SER254T, SER256T, SER292U, SER308T, SER53U, SER80T, SER82T, SER9T, THR103T, THR137U, THR155U, THR167U, THR236U, THR23T, THR255T, THR273T, THR314T, THR33T, TRP267U, TRP29T, TRP98T, TYR153U, TYR165U, TYR18T, TYR288U, TYR5T, VAL107T, VAL140U, VAL156U, VAL171U, VAL185U, VAL187U, VAL194U, VAL243T, VAL293U, VAL315T, VAL67U, VAL81T, VAL83T
• U-V: ALA11U, ALA122U, ALA142V, ALA146V, ALA154V, ALA15U, ALA16U, ALA177V, ALA179V, ALA19U, ALA20U, ALA220U, ALA222U, ALA223U, ALA249U, ALA48U, ALA56U, ALA63V, ALA76U, ALA7U, ARG14U, ARG157V, ARG178V, ARG209U, ARG209V, ARG225U, ARG251U, ARG272U, ARG279U, ARG65V, ARG96U, ASN133V, ASN166V, ASN170V, ASN193V, ASN234V, ASN238V, ASN253U, ASN62V, ASP101U, ASP151V, ASP168V, ASP174V, ASP175V, ASP189V, ASP213U, ASP217U, ASP239V, ASP6U, ASP78U, CYS109U, GLN17U, GLN182V, GLN278U, GLN64V, GLN93U, GLU105U, GLU145V, GLU160V, GLU244U, GLU248U, GLU275U, GLU290V, GLU52V, GLU77U, GLY104U, GLY108U, GLY124U, GLY135V, GLY144V, GLY148V, GLY149V, GLY159V, GLY164V, GLY219U, GLY226U, GLY274U, GLY276U, GLY79U, GLY94U, GLY97U, HIS141V, HIS183V, HIS22U, HIS291V, HIS3U, HIS95U, ILE176V, ILE186V, ILE207V, ILE218U, ILE2U, LEU102U, LEU106U, LEU139V, LEU13U, LEU162V, LEU214U, LEU215U, LEU245U, LEU277U, LEU294V, LEU4U, LEU99U, LYS12U, LYS131V, LYS136V, LYS150V, LYS152V, LYS192V, LYS247U, LYS75U, LYS8U, MET125U, MET180V, MET1U, MET221U, MET91U, PHE10U, PHE158V, PHE169V, PHE172V, PHE212U, PHE59V, PHE90V, PRO111U, PRO138V, PRO161V, PRO235V, SER110U, SER123U, SER163V, SER190V, SER208V, SER216U, SER224U, SER237V, SER250U, SER252U, SER254U, SER256U, SER292V, SER53V, SER80U, SER82U, SER9U, THR103U, THR137V, THR155V, THR167V, THR236V, THR23U, THR255U, THR273U, THR33U, TRP29U, TRP98U, TYR153V, TYR165V, TYR18U, TYR288V, TYR5U, VAL107U, VAL140V, VAL156V, VAL171V, VAL185V, VAL187V, VAL194V, VAL293V, VAL81U, VAL83U
• V-W: ALA311V, ALA63W, ARG14V, ARG157W, ARG178W, ARG209V, ARG272V, ARG65W, ARG96V, ASN133W, ASN62W, ASP168W, ASP174W, ASP175W, ASP189W, ASP213V, ASP217V, ASP239W, ASP240V, ASP6V, ASP78V, CYS109V, GLN64W, GLN93V, GLU145W, GLU160W, GLU244V, GLU248V, GLU275V, GLU52W, GLU71V, GLY108V, GLY79V, GLY94V, HIS141W, HIS291W, HIS3V, HIS95V, ILE2V, LYS136W, LYS152W, LYS192W, LYS310V, LYS75V, PHE212V, PHE59W, SER163W, SER53W, SER80V, THR155W, TYR153W, TYR165W, TYR5V, VAL67W, VAL81V, VAL83V
• W-X: ALA311W, ARG14W, ARG157X, ARG178X, ARG209W, ARG251W, ARG272W, ARG96W, ASN133X, ASP168X, ASP174X, ASP175X, ASP189X, ASP213W, ASP217W, ASP239X, ASP240X, ASP6W, ASP78W, CYS109W, GLU145X, GLU160X, GLU244W, GLU275W, GLU52X, GLY108W, HIS141X, HIS291X, HIS3W, HIS95W, LYS136X, LYS152X, LYS247W, LYS310W, PRO161X, SER163X, THR155X, THR167X, THR236X, THR255W, TYR153X, TYR5W