1W2W

crystal structure of yeast ypr118w, a methylthioribose-1- phosphate isomerase related to regulatory eif2b subunits

• Total interactions analyzed: 28
• Total true interactions: 13
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 227
  • Norm. En. per Res.: -5.6282
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-237.4249	-111.3425	-928.835	-1277.6023	227	31	35	37077	4	48	41
A-E	0.0	0.0	-5.3335	-5.3335	15	0	0	283	1	5	6
A-F	0.0	0.0	-0.4313	-0.4313	8	0	0	120	0	3	2
A-N	0.0	0.0	-22.4332	-22.4332	18	0	0	893	0	1	1
B-F	0.0	0.0	-0.0019	-0.0019	2	0	0	2	0	0	0
B-M	-10.1311	0.0	-23.4399	-33.571	16	1	0	895	0	0	0
B-N	-188.1905	-73.1846	-837.98	-1099.3551	219	32	36	33321	4	32	33
E-F	-201.5128	-107.9753	-922.474	-1231.962	230	26	36	36857	4	48	41
E-J	0.0	0.0	-18.5245	-18.5245	18	1	0	848	0	0	0
F-I	0.0	0.0	-25.4844	-25.4844	20	0	0	926	0	0	0
F-J	-212.5237	-91.2288	-837.469	-1141.2215	222	35	37	33779	6	34	32
I-J	-227.7087	-118.5304	-908.847	-1255.0861	227	38	35	36919	6	48	42
M-N	-192.0353	-103.7758	-918.452	-1214.2631	231	34	34	36625	5	47	42

Interface residues

• A-B: ALA109A, ALA149A, ALA159A, ALA176A, ALA187A, ALA194A, ALA207A, ALA243B, ALA262B, ALA274B, ALA275B, ALA279B, ALA289B, ALA298B, ALA312B, ALA378B, ALA53A, ALA57A, ALA5A, ARG106A, ARG199A, ARG223B, ARG233B, ARG240B, ARG264B, ARG281B, ARG332B, ARG51A, ASN111A, ASN114A, ASN150A, ASN151A, ASN157A, ASN182A, ASN236B, ASN290B, ASN319B, ASN333B, ASN355B, ASP147A, ASP156A, ASP164A, ASP169A, ASP173A, ASP204A, ASP210A, ASP22A, ASP249B, ASP258B, ASP280B, ASP318B, ASP380B, ASP388B, CYS181A, CYS221B, CYS301B, GLN167A, GLN237B, GLN23A, GLN296B, GLN49A, GLU146A, GLU174A, GLU231B, GLU245B, GLU330B, GLU331B, GLU336B, GLU359B, GLU393B, GLU394B, GLU4A, GLY155A, GLY158A, GLY170A, GLY184A, GLY190A, GLY192A, GLY196A, GLY225B, GLY238B, GLY278B, GLY293B, GLY342B, GLY363B, GLY389B, GLY395B, GLY52A, HIS226B, ILE163A, ILE180A, ILE198A, ILE251B, ILE256B, ILE261B, ILE265B, ILE270B, ILE272B, ILE282B, ILE292B, ILE300B, ILE306B, ILE317B, ILE327B, ILE328B, ILE345B, ILE361B, ILE381B, ILE391B, ILE45A, ILE56A, ILE58A, LEU103A, LEU112A, LEU143A, LEU162A, LEU166A, LEU178A, LEU186A, LEU195A, LEU201A, LEU206A, LEU21A, LEU230B, LEU241B, LEU246B, LEU24A, LEU255B, LEU25A, LEU26A, LEU295B, LEU297B, LEU352B, LEU354B, LEU3A, LYS153A, LYS160A, LYS168A, LYS172A, LYS203A, LYS208A, LYS250B, LYS273B, LYS291B, LYS307B, LYS314B, LYS31A, LYS364B, LYS46A, PHE171A, PHE175A, PHE228B, PHE276B, PHE304B, PHE308B, PHE309B, PHE379B, PHE397B, PRO107A, PRO222B, PRO229B, PRO252B, PRO269B, PRO271B, PRO27A, PRO313B, PRO360B, PRO54A, SER105A, SER113A, SER115A, SER185A, SER200A, SER205A, SER239B, SER253B, SER260B, SER268B, SER2A, SER43A, SER47A, THR108A, THR179A, THR183A, THR188A, THR193A, THR209A, THR232B, THR242B, THR254B, THR257B, THR294B, THR29A, THR30A, THR315B, THR316B, THR321B, THR341B, THR343B, THR362B, THR392B, THR398B, TRP202A, TYR139A, TYR161A, TYR191A, TYR235B, TYR244B, TYR248B, TYR28A, VAL110A, VAL117A, VAL165A, VAL177A, VAL197A, VAL227B, VAL247B, VAL277B, VAL283B, VAL310B, VAL311B, VAL320B, VAL329B, VAL344B, VAL396B, VAL44A, VAL50A
• A-E: ASN138A, ASP164E, CYS141A, GLN167E, GLU142A, GLY134A, LYS130A, LYS160E, LYS168E, LYS172E, PRO13A, SER11A, SER135A, TYR137A, TYR139A
• A-F: ALA149A, ASN400F, CYS221F, GLN406F, LYS130A, LYS153A, SER401F, SER402F
• A-N: ALA368N, GLU335N, GLU371N, GLY366N, ILE180A, ILE367N, ILE372N, LEU25A, LEU26A, LEU370N, LYS338N, PRO27A, PRO347N, PRO369N, SER259N, TYR28A, VAL339N, VAL365N
• B-F: GLU394B, SER401F
• B-M: ALA368B, GLU335B, GLU371B, GLY366B, ILE180M, ILE367B, ILE372B, LEU26M, LEU370B, LYS338B, PRO27M, PRO369B, SER259B, TYR28M, VAL339B, VAL365B
• B-N: ALA243B, ALA243N, ALA262B, ALA262N, ALA298B, ALA298N, ALA368B, ALA368N, ALA378B, ALA378N, ARG233B, ARG233N, ARG240B, ARG240N, ARG264B, ARG264N, ARG266B, ARG266N, ASN236B, ASN236N, ASN333B, ASN346B, ASN346N, ASN349N, ASN373B, ASN373N, ASN376B, ASN376N, ASP258B, ASP258N, ASP287B, ASP287N, ASP325B, ASP325N, ASP380B, ASP380N, CYS301B, CYS301N, GLN296B, GLN296N, GLN303B, GLN303N, GLU231B, GLU231N, GLU245B, GLU245N, GLU330B, GLU330N, GLU331B, GLU331N, GLU335B, GLU335N, GLU348B, GLU348N, GLU371B, GLU371N, GLU385B, GLU385N, GLY238B, GLY238N, GLY293B, GLY293N, GLY324B, GLY324N, GLY342B, GLY342N, GLY350B, GLY350N, GLY363B, GLY363N, GLY366B, GLY366N, HIS226B, HIS226N, HIS384B, HIS384N, ILE251B, ILE251N, ILE256B, ILE256N, ILE261B, ILE261N, ILE265B, ILE265N, ILE292B, ILE292N, ILE300B, ILE300N, ILE327B, ILE327N, ILE328B, ILE328N, ILE345B, ILE345N, ILE353B, ILE353N, ILE361B, ILE361N, ILE367B, ILE367N, ILE372B, ILE372N, ILE381B, ILE381N, LEU230B, LEU230N, LEU241B, LEU241N, LEU246B, LEU246N, LEU255B, LEU255N, LEU295B, LEU295N, LEU297B, LEU297N, LEU352B, LEU352N, LEU370B, LEU370N, LEU386B, LEU386N, LYS250B, LYS250N, LYS291B, LYS291N, LYS302B, LYS302N, LYS338B, LYS338N, LYS364B, LYS364N, PHE228B, PHE228N, PHE304B, PHE304N, PHE337B, PHE337N, PHE379B, PHE379N, PRO229B, PRO229N, PRO234B, PRO234N, PRO252B, PRO252N, PRO269B, PRO269N, PRO334N, PRO347B, PRO347N, PRO369B, PRO369N, PRO377B, PRO377N, PRO383B, PRO383N, SER239B, SER239N, SER253B, SER253N, SER259B, SER259N, SER260B, SER260N, SER268B, SER268N, SER351B, SER351N, THR232B, THR232N, THR242B, THR242N, THR254B, THR254N, THR257B, THR257N, THR267B, THR267N, THR288B, THR294B, THR294N, THR323B, THR341B, THR341N, THR343B, THR343N, THR362B, THR362N, THR382B, THR382N, TRP375B, TRP375N, TYR235B, TYR235N, TYR244B, TYR244N, TYR248B, TYR248N, TYR263B, TYR263N, VAL227B, VAL227N, VAL247B, VAL247N, VAL299B, VAL299N, VAL329B, VAL329N, VAL339B, VAL339N, VAL340B, VAL340N, VAL344B, VAL344N, VAL365B, VAL365N, VAL374B, VAL374N
• E-F: ALA109E, ALA149E, ALA159E, ALA176E, ALA187E, ALA194E, ALA207E, ALA243F, ALA262F, ALA274F, ALA275F, ALA279F, ALA289F, ALA298F, ALA312F, ALA378F, ALA53E, ALA57E, ALA5E, ARG106E, ARG199E, ARG223F, ARG233F, ARG240F, ARG264F, ARG281F, ARG332F, ARG51E, ASN111E, ASN114E, ASN150E, ASN151E, ASN157E, ASN182E, ASN236F, ASN290F, ASN319F, ASN333F, ASN355F, ASP147E, ASP156E, ASP164E, ASP169E, ASP173E, ASP204E, ASP210E, ASP22E, ASP249F, ASP258F, ASP280F, ASP318F, ASP380F, ASP388F, CYS181E, CYS221F, CYS301F, GLN167E, GLN237F, GLN23E, GLN296F, GLN49E, GLU146E, GLU174E, GLU231F, GLU245F, GLU330F, GLU331F, GLU336F, GLU359F, GLU393F, GLU394F, GLU4E, GLY155E, GLY158E, GLY170E, GLY184E, GLY190E, GLY192E, GLY196E, GLY225F, GLY238F, GLY278F, GLY293F, GLY342F, GLY363F, GLY389F, GLY395F, GLY52E, HIS226F, ILE163E, ILE180E, ILE198E, ILE251F, ILE256F, ILE261F, ILE265F, ILE270F, ILE272F, ILE282F, ILE292F, ILE300F, ILE306F, ILE317F, ILE327F, ILE328F, ILE345F, ILE361F, ILE381F, ILE390F, ILE391F, ILE45E, ILE56E, ILE58E, LEU103E, LEU112E, LEU143E, LEU162E, LEU166E, LEU178E, LEU186E, LEU195E, LEU201E, LEU206E, LEU21E, LEU230F, LEU241F, LEU246F, LEU24E, LEU255F, LEU25E, LEU26E, LEU295F, LEU297F, LEU352F, LEU354F, LEU3E, LEU410F, LYS153E, LYS160E, LYS168E, LYS172E, LYS203E, LYS208E, LYS250F, LYS273F, LYS291F, LYS307F, LYS314F, LYS31E, LYS364F, LYS399F, LYS46E, PHE171E, PHE175E, PHE228F, PHE276F, PHE304F, PHE308F, PHE309F, PHE379F, PHE397F, PRO107E, PRO222F, PRO229F, PRO252F, PRO269F, PRO271F, PRO27E, PRO313F, PRO360F, PRO54E, SER105E, SER113E, SER115E, SER185E, SER200E, SER205E, SER239F, SER253F, SER260F, SER268F, SER2E, SER43E, SER47E, THR108E, THR179E, THR183E, THR188E, THR193E, THR209E, THR232F, THR242F, THR254F, THR257F, THR294F, THR29E, THR30E, THR315F, THR316F, THR321F, THR341F, THR343F, THR362F, THR392F, THR398F, TRP202E, TYR139E, TYR161E, TYR191E, TYR235F, TYR244F, TYR248F, TYR28E, VAL110E, VAL117E, VAL165E, VAL177E, VAL197E, VAL227F, VAL247F, VAL277F, VAL283F, VAL310F, VAL311F, VAL320F, VAL329F, VAL344F, VAL396F, VAL44E, VAL50E
• E-J: ALA368J, GLU335J, GLU371J, GLY366J, ILE180E, ILE367J, ILE372J, LEU26E, LEU370J, LYS338J, PRO27E, PRO369J, SER259J, THR108E, TYR263J, TYR28E, VAL339J, VAL365J
• F-I: ALA368F, GLU335F, GLU371F, GLY366F, ILE180I, ILE367F, ILE372F, LEU178I, LEU25I, LEU26I, LEU370F, LYS338F, PRO27I, PRO347F, PRO369F, SER259F, TRP375F, TYR28I, VAL339F, VAL365F
• F-J: ALA243F, ALA243J, ALA262F, ALA262J, ALA289F, ALA289J, ALA298F, ALA298J, ALA368F, ALA368J, ALA378F, ALA378J, ARG233F, ARG233J, ARG240F, ARG240J, ARG264F, ARG264J, ARG266F, ARG266J, ASN236F, ASN236J, ASN346F, ASN346J, ASN349F, ASN349J, ASN373F, ASN373J, ASN376F, ASN376J, ASP258F, ASP258J, ASP287J, ASP325F, ASP325J, ASP326F, ASP380F, ASP380J, CYS301F, CYS301J, GLN296F, GLN296J, GLN303F, GLN303J, GLU231F, GLU231J, GLU245F, GLU245J, GLU330F, GLU330J, GLU331F, GLU331J, GLU335F, GLU335J, GLU348F, GLU348J, GLU371F, GLU371J, GLU385F, GLU385J, GLY238F, GLY238J, GLY293F, GLY293J, GLY324F, GLY324J, GLY342F, GLY342J, GLY350F, GLY350J, GLY363F, GLY363J, GLY366F, GLY366J, HIS226F, HIS226J, HIS384J, ILE251F, ILE251J, ILE256F, ILE256J, ILE261F, ILE261J, ILE265F, ILE265J, ILE272J, ILE292F, ILE292J, ILE300F, ILE300J, ILE327F, ILE327J, ILE328F, ILE328J, ILE345F, ILE345J, ILE353F, ILE353J, ILE361F, ILE361J, ILE367F, ILE367J, ILE372F, ILE372J, ILE381F, ILE381J, LEU230F, LEU230J, LEU241F, LEU241J, LEU246F, LEU246J, LEU255F, LEU255J, LEU295F, LEU295J, LEU297F, LEU297J, LEU352F, LEU352J, LEU370F, LEU370J, LEU386F, LEU386J, LYS250F, LYS291F, LYS291J, LYS302F, LYS302J, LYS338F, LYS338J, LYS364F, LYS364J, PHE228F, PHE228J, PHE304F, PHE304J, PHE337F, PHE337J, PHE379F, PHE379J, PRO229F, PRO229J, PRO234F, PRO234J, PRO252F, PRO252J, PRO269F, PRO269J, PRO334F, PRO334J, PRO347F, PRO347J, PRO369F, PRO369J, PRO377F, PRO377J, PRO383F, PRO383J, SER239F, SER239J, SER253F, SER253J, SER259F, SER259J, SER260F, SER260J, SER268F, SER268J, SER351F, SER351J, THR232F, THR232J, THR242F, THR242J, THR254F, THR254J, THR257F, THR257J, THR267F, THR267J, THR288J, THR294F, THR294J, THR323F, THR323J, THR341F, THR341J, THR343F, THR343J, THR362F, THR362J, THR382F, THR382J, TRP375F, TRP375J, TYR235F, TYR235J, TYR244F, TYR244J, TYR248F, TYR248J, TYR263F, TYR263J, VAL227F, VAL227J, VAL247F, VAL247J, VAL299F, VAL299J, VAL329F, VAL329J, VAL339F, VAL339J, VAL340F, VAL340J, VAL344F, VAL344J, VAL365F, VAL365J, VAL374F, VAL374J
• I-J: ALA109I, ALA149I, ALA159I, ALA176I, ALA187I, ALA194I, ALA207I, ALA243J, ALA262J, ALA274J, ALA275J, ALA279J, ALA289J, ALA298J, ALA312J, ALA378J, ALA53I, ALA57I, ALA5I, ARG106I, ARG199I, ARG223J, ARG233J, ARG240J, ARG264J, ARG281J, ARG332J, ARG51I, ASN111I, ASN114I, ASN150I, ASN151I, ASN157I, ASN182I, ASN236J, ASN290J, ASN319J, ASN333J, ASP147I, ASP156I, ASP164I, ASP169I, ASP173I, ASP204I, ASP210I, ASP22I, ASP249J, ASP258J, ASP280J, ASP318J, ASP380J, ASP388J, CYS181I, CYS221J, CYS301J, GLN167I, GLN237J, GLN23I, GLN296J, GLN49I, GLU146I, GLU174I, GLU231J, GLU245J, GLU330J, GLU331J, GLU336J, GLU359J, GLU393J, GLU394J, GLU4I, GLY155I, GLY158I, GLY170I, GLY184I, GLY190I, GLY192I, GLY196I, GLY225J, GLY238J, GLY278J, GLY293J, GLY342J, GLY363J, GLY389J, GLY395J, GLY52I, HIS226J, ILE163I, ILE180I, ILE198I, ILE251J, ILE256J, ILE261J, ILE265J, ILE270J, ILE272J, ILE282J, ILE292J, ILE300J, ILE306J, ILE317J, ILE327J, ILE328J, ILE345J, ILE361J, ILE381J, ILE391J, ILE45I, ILE56I, ILE58I, LEU103I, LEU112I, LEU143I, LEU162I, LEU166I, LEU178I, LEU186I, LEU195I, LEU201I, LEU206I, LEU21I, LEU230J, LEU241J, LEU246J, LEU24I, LEU255J, LEU25I, LEU26I, LEU295J, LEU297J, LEU352J, LEU354J, LEU3I, LEU410J, LYS153I, LYS160I, LYS168I, LYS172I, LYS203I, LYS208I, LYS211I, LYS250J, LYS273J, LYS291J, LYS307J, LYS314J, LYS31I, LYS364J, LYS399J, LYS46I, PHE171I, PHE175I, PHE228J, PHE276J, PHE304J, PHE308J, PHE309J, PHE379J, PHE397J, PRO107I, PRO222J, PRO229J, PRO252J, PRO269J, PRO271J, PRO27I, PRO313J, PRO360J, PRO54I, SER105I, SER113I, SER115I, SER185I, SER200I, SER205I, SER239J, SER253J, SER260J, SER268J, SER2I, SER47I, THR108I, THR179I, THR183I, THR188I, THR193I, THR209I, THR232J, THR242J, THR254J, THR257J, THR294J, THR29I, THR30I, THR315J, THR316J, THR321J, THR341J, THR343J, THR362J, THR392J, THR398J, TRP202I, TYR139I, TYR161I, TYR191I, TYR235J, TYR244J, TYR248J, TYR28I, VAL110I, VAL165I, VAL177I, VAL197I, VAL227J, VAL247J, VAL277J, VAL283J, VAL310J, VAL311J, VAL320J, VAL329J, VAL344J, VAL396J, VAL44I, VAL50I
• M-N: ALA109M, ALA149M, ALA159M, ALA176M, ALA187M, ALA194M, ALA207M, ALA243N, ALA262N, ALA274N, ALA275N, ALA279N, ALA289N, ALA298N, ALA312N, ALA378N, ALA53M, ALA57M, ALA5M, ARG106M, ARG199M, ARG223N, ARG233N, ARG240N, ARG264N, ARG281N, ARG332N, ARG51M, ASN111M, ASN114M, ASN150M, ASN151M, ASN157M, ASN182M, ASN236N, ASN290N, ASN319N, ASN333N, ASN355N, ASP147M, ASP156M, ASP164M, ASP169M, ASP173M, ASP204M, ASP210M, ASP22M, ASP249N, ASP258N, ASP280N, ASP318N, ASP380N, ASP388N, CYS181M, CYS221N, CYS301N, GLN167M, GLN237N, GLN23M, GLN296N, GLN49M, GLU146M, GLU174M, GLU231N, GLU245N, GLU330N, GLU331N, GLU336N, GLU359N, GLU393N, GLU394N, GLU4M, GLY155M, GLY158M, GLY170M, GLY184M, GLY190M, GLY192M, GLY196M, GLY225N, GLY238N, GLY278N, GLY293N, GLY342N, GLY363N, GLY389N, GLY395N, GLY52M, HIS226N, ILE163M, ILE180M, ILE198M, ILE251N, ILE256N, ILE261N, ILE265N, ILE270N, ILE272N, ILE282N, ILE292N, ILE300N, ILE306N, ILE317N, ILE327N, ILE328N, ILE345N, ILE361N, ILE381N, ILE390N, ILE391N, ILE45M, ILE56M, ILE58M, LEU103M, LEU112M, LEU143M, LEU162M, LEU166M, LEU178M, LEU186M, LEU195M, LEU201M, LEU206M, LEU21M, LEU230N, LEU241N, LEU246N, LEU24M, LEU255N, LEU25M, LEU26M, LEU295N, LEU297N, LEU352N, LEU354N, LEU3M, LEU410N, LYS153M, LYS160M, LYS168M, LYS172M, LYS203M, LYS208M, LYS211M, LYS250N, LYS273N, LYS291N, LYS307N, LYS314N, LYS31M, LYS364N, LYS399N, LYS46M, PHE171M, PHE175M, PHE228N, PHE276N, PHE304N, PHE308N, PHE309N, PHE379N, PHE397N, PRO107M, PRO222N, PRO229N, PRO252N, PRO269N, PRO271N, PRO27M, PRO313N, PRO360N, PRO54M, SER104M, SER105M, SER113M, SER115M, SER185M, SER200M, SER205M, SER239N, SER253N, SER260N, SER268N, SER2M, SER47M, THR108M, THR179M, THR183M, THR188M, THR193M, THR209M, THR232N, THR242N, THR254N, THR257N, THR294N, THR29M, THR30M, THR315N, THR316N, THR321N, THR341N, THR343N, THR362N, THR392N, THR398N, TRP202M, TYR139M, TYR161M, TYR191M, TYR235N, TYR244N, TYR248N, TYR28M, VAL110M, VAL117M, VAL165M, VAL177M, VAL197M, VAL227N, VAL247N, VAL277N, VAL283N, VAL310N, VAL311N, VAL320N, VAL329N, VAL344N, VAL396N, VAL44M, VAL50M