1W1H

crystal structure of the pdk1 pleckstrin homology (ph) domain

• Total interactions analyzed: 6
• Total true interactions: 4
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 41
  • Norm. En. per Res.: -3.5731
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	13.2145	-46.3443	-33.1298	32	3	0	2155	0	10	14
A-C	0.0	0.0	-0.0005	-0.0005	2	0	0	1	0	1	0
A-D	-4.8461	0.0	-38.8788	-43.7249	24	1	0	1904	0	4	6
C-D	-14.7241	-28.69	-103.082	-146.4961	41	5	2	4165	2	16	17

Interface residues

• A-B: ALA471B, ARG466A, ARG472B, ARG474B, ARG505A, ARG521A, ASN491B, ASN520A, ASP488B, GLN502A, GLU503A, GLU507A, GLY468B, HIS517A, LEU469B, LEU525A, LYS467B, LYS495B, LYS509A, PHE470B, PHE514A, PHE515A, PRO519A, SER501A, THR513A, THR518A, THR522A, TYR523A, TYR524A, VAL490B, VAL493B, VAL516A
• A-C: ASN411C, LYS492A
• A-D: ARG521D, ARG546D, ASN491A, ASN520D, ASP488A, GLN450A, GLN502D, GLU503D, GLY496A, LEU494A, LEU504D, LYS467A, LYS492A, LYS495A, PHE451A, PRO489A, PRO499D, PRO519D, SER501D, THR518D, TRP500D, TYR547D, VAL490A, VAL493A
• C-D: ALA443C, ARG436C, ARG466D, ARG521D, ASN411C, ASN446C, ASN454C, ASN455C, ASN510D, ASN520D, ASP433C, GLN442C, GLU440C, GLU453C, GLU480C, GLY444C, GLY445C, GLY468D, HIS449C, HIS517D, ILE412C, LEU437C, LEU438C, LEU439C, LEU456C, LEU469D, LYS435C, LYS441C, LYS465D, LYS467D, LYS509D, MET526D, PHE470D, PHE515D, PRO447C, PRO519D, THR513D, THR522D, TYR523D, TYR524D, VAL452C