1VU0

structure-function analysis of receptor-binding in adeno-associated virus serotype 6 (aav-6)

• Total interactions analyzed: 190
• Total true interactions: 39
• Strongest Interaction:
  • Chains: U-Z
  • Int. Res.: 137
  • Norm. En. per Res.: -5.6258
• Hub Node: U(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
U-V	-70.3163	-3.9619	-683.727	-758.0051	215	51	13	26605	1	19	18
U-W	0.0	0.0	-0.0281	-0.0281	5	0	0	15	0	0	1
U-X	0.0	0.0	-0.0273	-0.0273	5	0	0	16	0	0	1
U-Y	-70.4206	-3.6942	-661.701	-735.8158	213	39	13	26059	1	19	17
U-Z	-163.2064	-232.6542	-374.874	-770.7346	137	30	2	15436	15	32	35
U-c	0.0	0.0	-6.9511	-6.9511	12	0	2	479	0	0	1
U-d	-309.5386	-25.7414	-1508.67	-1843.9499	342	131	27	58614	7	60	64
V-W	-76.2867	-2.3847	-671.062	-749.7334	214	43	13	26341	1	19	17
V-X	0.0	0.0	-0.0266	-0.0266	5	0	0	14	0	0	1
V-Y	0.0	0.0	-0.0169	-0.0169	5	0	0	13	0	0	1
W-X	-70.2718	-2.6605	-643.372	-716.3043	213	44	13	26007	1	19	17
W-Y	0.0	0.0	-0.0231	-0.0231	5	0	0	14	0	0	1
X-Y	-74.017	-2.9023	-669.337	-746.2563	213	44	13	26278	1	19	17
X-Z	0.0	0.0	-7.2045	-7.2045	12	0	2	468	0	0	1
Y-Z	-314.9396	-19.8579	-1530.59	-1865.3875	341	135	27	58653	7	61	65
Z-a	-77.1157	-3.0442	-656.995	-737.1549	213	44	13	26262	1	19	17
Z-b	0.0	0.0	-0.0141	-0.0141	5	0	0	11	0	0	1
Z-c	0.0	0.0	-0.0274	-0.0274	5	0	0	15	0	0	1
Z-d	-80.9397	-4.6297	-670.053	-755.6224	213	46	13	26596	1	19	18
a-b	-80.7403	-2.277	-663.651	-746.6684	214	42	13	26324	1	19	17
a-c	0.0	0.0	-0.026	-0.026	5	0	0	14	0	0	1
a-d	0.0	0.0	-0.014	-0.014	5	0	0	11	0	0	1
b-c	-70.5589	-3.4113	-648.223	-722.1931	214	51	13	26211	1	19	17
b-d	0.0	0.0	-0.0165	-0.0165	5	0	0	13	0	0	1
c-d	-69.3079	-3.475	-653.817	-726.5999	214	39	13	26124	1	19	18
e-f	-73.509	-5.2643	-673.502	-752.2753	215	45	14	26690	1	19	18
e-g	0.0	0.0	-0.0275	-0.0275	6	0	0	17	0	0	1
e-i	-83.4981	-3.948			24
e-j	-160.5634	-236.4945			28
e-n	-328.9821	-24.6356			84
f-g	-73.0968	-3.9307	-456.553	-533.5805	171	29	9	18115	1	14	14
g-h	-94.9239	-2.2407			26
h-i	-96.1297	-4.452			27
i-j	-327.7967	-22.8476			82
j-k	-88.7377	-3.0803			23
j-n	-97.0404	-2.8696			26
k-l	-81.8924	-3.4145			22
l-m	-78.4574	-4.0294			23
m-n	-88.6983	-4.2038			27

Interface residues

• U-V: ALA218U, ALA224V, ALA248V, ALA263U, ALA334U, ALA334V, ALA368V, ALA387U, ALA548V, ALA656U, ALA660U, ALA664U, ALA668U, ALA706V, ALA709V, ARG245V, ARG287V, ARG295V, ARG299V, ARG390U, ARG405U, ARG405V, ASN223U, ASN223V, ASN227V, ASN253U, ASN253V, ASN254V, ASN318V, ASN327U, ASN335U, ASN335V, ASN336U, ASN336V, ASN382U, ASN383U, ASN408U, ASN408V, ASN409U, ASN409V, ASN651V, ASN657U, ASN704V, ASN710V, ASN717V, ASN718V, ASP219U, ASP219V, ASP231V, ASP296V, ASP328U, ASP369V, ASP712V, ASP716V, CYS230V, CYS290V, CYS362V, CYS395U, GLN259U, GLN320V, GLN342U, GLN350U, GLN360V, GLN375V, GLN386U, GLN402U, GLN673U, GLN673V, GLN678V, GLU323U, GLU323V, GLU348U, GLU397U, GLU546V, GLU661U, GLY217U, GLY220U, GLY220V, GLY222U, GLY222V, GLY226V, GLY275U, GLY281V, GLY329V, GLY361V, GLY384U, GLY389U, GLY407U, GLY407V, GLY677V, GLY719V, HIS229V, HIS255U, HIS291V, HIS359V, ILE240V, ILE260U, ILE319U, ILE319V, ILE333V, ILE373V, ILE671U, LEU249V, LEU256U, LEU337U, LEU337V, LEU381U, LEU396U, LEU404U, LEU720V, LYS258U, LYS258V, LYS322V, LYS650U, LYS666U, LYS707V, MET372V, MET403U, PHE274U, PHE292V, PHE317V, PHE344U, PHE366V, PHE371V, PHE393U, PHE399U, PHE410U, PHE662U, PHE667U, PHE670U, PHE713V, PRO250V, PRO279U, PRO294V, PRO364V, PRO365V, PRO367V, PRO374V, PRO400U, PRO653U, PRO655U, PRO658U, PRO659U, SER225V, SER232V, SER243V, SER261U, SER277U, SER293V, SER339U, SER385U, SER391U, SER392U, SER401U, SER663U, SER669U, SER675V, SER703V, SER708V, THR233V, THR241V, THR242V, THR244V, THR246V, THR251V, THR278U, THR325U, THR325V, THR326U, THR326V, THR331V, THR332V, THR338U, THR340U, THR380U, THR406U, THR406V, THR652U, THR665U, THR672U, THR672V, THR676V, THR702V, THR714V, THR722V, TRP228V, TRP234V, TRP247V, TRP280U, TRP297V, TYR252V, TYR257U, TYR276U, TYR282V, TYR376V, TYR378U, TYR394U, TYR398U, TYR674V, TYR705V, TYR721V, VAL221U, VAL221V, VAL239V, VAL321U, VAL321V, VAL324V, VAL330V, VAL341U, VAL343U, VAL370V, VAL388U, VAL654U, VAL711V, VAL715V
• U-W: ARG405U, GLY222W, LEU337U, LEU337W, THR338U
• U-X: ARG405X, GLY222U, LEU337U, LEU337X, THR338X
• U-Y: ALA218Y, ALA224U, ALA248U, ALA263Y, ALA334U, ALA334Y, ALA368U, ALA387Y, ALA548U, ALA656Y, ALA660Y, ALA664Y, ALA668Y, ALA706U, ALA709U, ARG245U, ARG287U, ARG295U, ARG299U, ARG390Y, ARG405U, ARG405Y, ASN223U, ASN223Y, ASN227U, ASN253U, ASN253Y, ASN254U, ASN318U, ASN327Y, ASN335U, ASN335Y, ASN336U, ASN336Y, ASN382Y, ASN383Y, ASN408U, ASN408Y, ASN409Y, ASN651U, ASN657Y, ASN704U, ASN710U, ASN717U, ASN718U, ASP219U, ASP219Y, ASP231U, ASP296U, ASP328Y, ASP369U, ASP712U, ASP716U, CYS230U, CYS290U, CYS362U, CYS395Y, GLN259Y, GLN320U, GLN342Y, GLN350Y, GLN360U, GLN375U, GLN386Y, GLN402Y, GLN673U, GLN673Y, GLN678U, GLU323U, GLU323Y, GLU348Y, GLU397Y, GLU546U, GLU661Y, GLY217Y, GLY220U, GLY220Y, GLY222U, GLY222Y, GLY226U, GLY275Y, GLY281U, GLY329U, GLY361U, GLY384Y, GLY389Y, GLY407U, GLY407Y, GLY677U, GLY719U, HIS229U, HIS255Y, HIS291U, HIS359U, ILE240U, ILE260Y, ILE319U, ILE333U, ILE373U, ILE671Y, LEU249U, LEU256Y, LEU337U, LEU337Y, LEU381Y, LEU396Y, LEU404Y, LEU720U, LYS258U, LYS258Y, LYS322U, LYS650Y, LYS666Y, LYS707U, MET372U, MET403Y, PHE274Y, PHE292U, PHE317U, PHE344Y, PHE366U, PHE371U, PHE393Y, PHE399Y, PHE410Y, PHE662Y, PHE667Y, PHE670Y, PHE713U, PRO250U, PRO279Y, PRO294U, PRO364U, PRO365U, PRO367U, PRO374U, PRO400Y, PRO653Y, PRO655Y, PRO658Y, PRO659Y, SER225U, SER232U, SER243U, SER261Y, SER277Y, SER293U, SER339Y, SER385Y, SER391Y, SER392Y, SER401Y, SER663Y, SER669Y, SER675U, SER703U, SER708U, THR233U, THR241U, THR242U, THR244U, THR246U, THR251U, THR278Y, THR325U, THR325Y, THR326U, THR326Y, THR331U, THR332U, THR338Y, THR340Y, THR380Y, THR406U, THR406Y, THR652Y, THR665Y, THR672U, THR672Y, THR676U, THR702U, THR714U, THR722U, TRP228U, TRP234U, TRP247U, TRP280Y, TRP297U, TYR252U, TYR257Y, TYR276Y, TYR282U, TYR376U, TYR378Y, TYR394Y, TYR398Y, TYR674U, TYR705U, TYR721U, VAL221U, VAL221Y, VAL239U, VAL321U, VAL321Y, VAL324U, VAL330U, VAL341Y, VAL343Y, VAL370U, VAL388Y, VAL654Y, VAL711U, VAL715U
• U-Z: ALA368U, ALA368Z, ALA706U, ALA706Z, ARG245U, ARG245Z, ARG295U, ARG295Z, ARG299U, ARG299Z, ARG694U, ARG694Z, ARG725U, ARG725Z, ASN302U, ASN302Z, ASN303U, ASN303Z, ASN304U, ASN304Z, ASN691U, ASN691Z, ASN696U, ASN696Z, ASN704U, ASN704Z, ASP231U, ASP231Z, ASP296U, ASP296Z, ASP529U, ASP529Z, ASP530U, ASP530Z, ASP532U, ASP532Z, ASP712U, ASP712Z, CYS230U, CYS230Z, CYS290U, CYS290Z, GLN298U, GLN298Z, GLN700U, GLN700Z, GLU564U, GLU564Z, GLU565U, GLU565Z, GLU690U, GLU690Z, GLU698U, GLU698Z, GLU723U, GLU723Z, GLY236U, GLY236Z, HIS289U, HIS289Z, HIS291U, HIS291Z, HIS527U, ILE301U, ILE301Z, ILE727U, ILE727Z, LEU614U, LEU614Z, LEU732U, LEU732Z, LYS567U, LYS567Z, LYS689U, LYS689Z, LYS693U, LYS693Z, LYS707U, LYS707Z, PHE292U, PHE292Z, PHE366U, PHE366Z, PHE713U, PHE713Z, PRO294U, PRO294Z, PRO364U, PRO364Z, PRO365U, PRO365Z, PRO367U, PRO367Z, PRO697U, PRO697Z, PRO724U, PRO724Z, SER232U, SER232Z, SER243U, SER243Z, SER293U, SER293Z, SER692U, SER692Z, SER703U, SER703Z, THR233U, THR233Z, THR702U, THR702Z, THR714U, THR714Z, THR733U, THR733Z, TRP234U, TRP234Z, TRP297U, TRP297Z, TRP305U, TRP305Z, TRP695U, TRP695Z, TYR701U, TYR701Z, TYR705U, TYR705Z, TYR721U, TYR721Z, TYR731U, TYR731Z, VAL699U, VAL699Z, VAL711U, VAL711Z, VAL715U, VAL715Z
• U-c: ALA664c, ARG465U, ASN436U, ASP440U, GLN441U, GLU661c, ILE439U, LEU438U, PHE662c, SER663c, THR665c, TYR442U
• U-d: ALA267d, ALA358d, ALA426U, ALA456U, ALA469U, ALA506d, ALA523d, ALA525U, ALA548d, ALA550d, ALA554d, ALA568U, ALA573d, ALA581U, ALA592U, ALA601U, ALA601d, ALA620d, ARG287d, ARG390d, ARG433U, ARG448U, ARG465U, ARG485U, ARG485d, ARG488d, ARG514d, ARG576U, ARG576d, ARG610U, ARG610d, ARG694U, ARG730U, ARG734U, ASN253d, ASN269d, ASN271d, ASN286d, ASN302U, ASN382d, ASN383d, ASN436U, ASN447U, ASN451U, ASN458U, ASN477U, ASN496d, ASN497d, ASN498d, ASN500d, ASN510U, ASN510d, ASN512d, ASN519d, ASN552d, ASN557d, ASN570U, ASN570d, ASN583U, ASN691U, ASN696U, ASP270d, ASP284d, ASP346d, ASP432U, ASP440U, ASP460U, ASP495d, ASP529U, ASP530U, ASP556d, ASP590U, ASP595U, ASP595d, ASP609U, ASP609d, ASP611U, ASP626d, CYS362d, CYS395d, CYS483U, CYS483d, GLN350d, GLN360d, GLN375d, GLN386d, GLN429U, GLN441U, GLN450U, GLN452U, GLN457U, GLN474U, GLN486d, GLN487d, GLN585U, GLN608U, GLN608d, GLN615d, GLN646d, GLN688U, GLN700U, GLU348d, GLU397d, GLU515d, GLU546d, GLU564U, GLU565U, GLU575U, GLU575d, GLU698U, GLY266d, GLY275d, GLY281d, GLY306U, GLY356d, GLY361d, GLY377d, GLY384d, GLY389d, GLY466U, GLY470U, GLY481U, GLY481d, GLY505d, GLY513d, GLY521d, GLY539d, GLY544d, GLY549d, GLY578U, GLY594U, GLY600U, GLY600d, GLY604U, GLY616d, GLY627U, GLY627d, GLY636d, GLY637U, GLY637d, GLY639d, HIS272d, HIS289d, HIS359d, HIS422U, HIS427U, HIS527U, HIS597U, HIS597d, HIS624d, HIS628U, HIS628d, HIS630U, HIS630d, ILE260d, ILE373d, ILE439U, ILE517d, ILE518d, ILE542d, ILE560d, ILE566U, ILE618d, ILE622d, LEU351d, LEU355d, LEU379d, LEU381d, LEU396d, LEU431U, LEU434U, LEU438U, LEU443U, LEU446U, LEU461U, LEU462U, LEU479U, LEU511d, LEU555d, LEU584U, LEU584d, LEU602U, LEU602d, LEU634d, LEU640d, LEU732U, LEU736U, LYS258d, LYS459U, LYS476U, LYS491d, LYS493d, LYS508d, LYS528U, LYS528d, LYS531U, LYS531d, LYS533d, LYS545d, LYS567U, LYS621d, LYS693U, MET435U, MET471U, MET524d, MET537d, MET541d, MET559d, MET599U, MET599d, MET605U, MET605d, MET635d, PHE274d, PHE288d, PHE344d, PHE393d, PHE399d, PHE421U, PHE463U, PHE501d, PHE534d, PHE535d, PHE543d, PHE577U, PHE629U, PHE629d, PHE638d, PRO279d, PRO352d, PRO374d, PRO400d, PRO420U, PRO437U, PRO468U, PRO475U, PRO480U, PRO482U, PRO482d, PRO520d, PRO536d, PRO571U, PRO591U, PRO603U, PRO603d, PRO617d, PRO623d, PRO631d, PRO633d, PRO697U, PRO735U, SER261d, SER262d, SER268d, SER277d, SER357d, SER385d, SER391d, SER392d, SER423U, SER424U, SER428U, SER430U, SER464U, SER467U, SER472U, SER490d, SER499d, SER507d, SER516d, SER538d, SER547d, SER551d, SER586U, SER587U, SER588U, SER632U, SER632d, SER692U, THR265d, THR278d, THR380d, THR449U, THR492d, THR494d, THR502d, THR504d, THR522d, THR553d, THR561d, THR569U, THR574U, THR574d, THR579U, THR589U, THR593U, THR625d, THR729U, THR733U, TRP280d, TRP305U, TRP478U, TRP503d, TRP607U, TRP607d, TRP619d, TRP695U, TYR252d, TYR273d, TYR276d, TYR282d, TYR349d, TYR353d, TYR376d, TYR378d, TYR394d, TYR398d, TYR425U, TYR442U, TYR444U, TYR445U, TYR484d, TYR509d, TYR613d, TYR701U, TYR731U, VAL354d, VAL388d, VAL473U, VAL489d, VAL540d, VAL558d, VAL572U, VAL572d, VAL580U, VAL582U, VAL596U, VAL596d, VAL598U, VAL598d, VAL606U, VAL699U
• V-W: ALA218V, ALA224W, ALA248W, ALA263V, ALA334V, ALA334W, ALA368W, ALA387V, ALA548W, ALA656V, ALA660V, ALA664V, ALA668V, ALA706W, ALA709W, ARG245W, ARG287W, ARG295W, ARG299W, ARG390V, ARG405V, ARG405W, ASN223V, ASN223W, ASN227W, ASN253V, ASN253W, ASN254W, ASN318W, ASN327V, ASN335V, ASN335W, ASN336V, ASN336W, ASN382V, ASN383V, ASN408V, ASN408W, ASN409V, ASN409W, ASN651W, ASN657V, ASN704W, ASN710W, ASN717W, ASN718W, ASP219V, ASP219W, ASP231W, ASP296W, ASP328V, ASP369W, ASP712W, ASP716W, CYS230W, CYS290W, CYS362W, CYS395V, GLN259V, GLN320W, GLN342V, GLN350V, GLN360W, GLN375W, GLN386V, GLN402V, GLN673V, GLN673W, GLN678W, GLU323V, GLU323W, GLU348V, GLU397V, GLU546W, GLU661V, GLY217V, GLY220V, GLY220W, GLY222V, GLY222W, GLY226W, GLY275V, GLY281W, GLY329W, GLY361W, GLY384V, GLY389V, GLY407V, GLY407W, GLY677W, GLY719W, HIS229W, HIS255V, HIS291W, HIS359W, ILE240W, ILE260V, ILE319V, ILE319W, ILE333W, ILE373W, ILE671V, LEU249W, LEU256V, LEU337V, LEU337W, LEU381V, LEU396V, LEU404V, LEU720W, LYS258V, LYS258W, LYS322W, LYS650V, LYS666V, LYS707W, MET372W, MET403V, PHE274V, PHE292W, PHE317W, PHE344V, PHE366W, PHE371W, PHE393V, PHE399V, PHE410V, PHE662V, PHE667V, PHE670V, PHE713W, PRO250W, PRO279V, PRO294W, PRO364W, PRO365W, PRO367W, PRO374W, PRO400V, PRO653V, PRO655V, PRO658V, PRO659V, SER225W, SER232W, SER243W, SER261V, SER277V, SER293W, SER339V, SER385V, SER391V, SER392V, SER401V, SER663V, SER669V, SER675W, SER703W, SER708W, THR233W, THR241W, THR242W, THR244W, THR246W, THR251W, THR278V, THR325V, THR325W, THR326V, THR326W, THR331W, THR332W, THR338V, THR340V, THR380V, THR406V, THR406W, THR652V, THR665V, THR672V, THR672W, THR676W, THR702W, THR714W, THR722W, TRP228W, TRP234W, TRP247W, TRP280V, TRP297W, TYR252W, TYR257V, TYR276V, TYR282W, TYR376W, TYR378V, TYR394V, TYR398V, TYR674W, TYR705W, TYR721W, VAL221V, VAL221W, VAL321V, VAL321W, VAL324W, VAL330W, VAL341V, VAL343V, VAL370W, VAL388V, VAL654V, VAL711W, VAL715W
• V-X: ARG405V, GLY222X, LEU337V, LEU337X, THR338V
• V-Y: ARG405Y, GLY222V, LEU337V, LEU337Y, THR338Y
• W-X: ALA218W, ALA224X, ALA248X, ALA263W, ALA334W, ALA334X, ALA368X, ALA387W, ALA548X, ALA656W, ALA660W, ALA664W, ALA668W, ALA706X, ALA709X, ARG245X, ARG287X, ARG295X, ARG299X, ARG390W, ARG405W, ARG405X, ASN223W, ASN223X, ASN227X, ASN253W, ASN253X, ASN254X, ASN318X, ASN327W, ASN335W, ASN335X, ASN336W, ASN336X, ASN382W, ASN383W, ASN408W, ASN408X, ASN409W, ASN651X, ASN657W, ASN704X, ASN710X, ASN717X, ASN718X, ASP219W, ASP219X, ASP231X, ASP296X, ASP328W, ASP369X, ASP712X, ASP716X, CYS230X, CYS290X, CYS362X, CYS395W, GLN259W, GLN320X, GLN342W, GLN350W, GLN360X, GLN375X, GLN386W, GLN402W, GLN673W, GLN673X, GLN678X, GLU323W, GLU323X, GLU348W, GLU397W, GLU546X, GLU661W, GLY217W, GLY220W, GLY220X, GLY222W, GLY222X, GLY226X, GLY275W, GLY281X, GLY329X, GLY361X, GLY384W, GLY389W, GLY407W, GLY407X, GLY677X, GLY719X, HIS229X, HIS255W, HIS291X, HIS359X, ILE240X, ILE260W, ILE319W, ILE319X, ILE333X, ILE373X, ILE671W, LEU249X, LEU256W, LEU337W, LEU337X, LEU381W, LEU396W, LEU404W, LEU720X, LYS258W, LYS258X, LYS322X, LYS650W, LYS666W, LYS707X, MET372X, MET403W, PHE274W, PHE292X, PHE317X, PHE344W, PHE366X, PHE371X, PHE393W, PHE399W, PHE410W, PHE662W, PHE667W, PHE670W, PHE713X, PRO250X, PRO279W, PRO294X, PRO364X, PRO365X, PRO367X, PRO374X, PRO400W, PRO653W, PRO655W, PRO658W, PRO659W, SER225X, SER232X, SER243X, SER261W, SER277W, SER293X, SER339W, SER385W, SER391W, SER392W, SER401W, SER663W, SER669W, SER675X, SER703X, SER708X, THR233X, THR241X, THR242X, THR244X, THR246X, THR251X, THR278W, THR325W, THR325X, THR326W, THR326X, THR331X, THR332X, THR338W, THR340W, THR380W, THR406W, THR406X, THR652W, THR665W, THR672W, THR672X, THR676X, THR702X, THR714X, THR722X, TRP228X, TRP234X, TRP247X, TRP280W, TRP297X, TYR252X, TYR257W, TYR276W, TYR282X, TYR376X, TYR378W, TYR394W, TYR398W, TYR674X, TYR705X, TYR721X, VAL221W, VAL221X, VAL321W, VAL321X, VAL324X, VAL330X, VAL341W, VAL343W, VAL370X, VAL388W, VAL654W, VAL711X, VAL715X
• W-Y: ARG405W, GLY222Y, LEU337W, LEU337Y, THR338W
• X-Y: ALA218X, ALA224Y, ALA248Y, ALA263X, ALA334X, ALA334Y, ALA368Y, ALA387X, ALA548Y, ALA656X, ALA660X, ALA664X, ALA668X, ALA706Y, ALA709Y, ARG245Y, ARG287Y, ARG295Y, ARG299Y, ARG390X, ARG405X, ARG405Y, ASN223X, ASN223Y, ASN227Y, ASN253X, ASN253Y, ASN254Y, ASN318Y, ASN327X, ASN335X, ASN335Y, ASN336X, ASN336Y, ASN382X, ASN383X, ASN408X, ASN408Y, ASN409X, ASN651Y, ASN657X, ASN704Y, ASN710Y, ASN717Y, ASN718Y, ASP219X, ASP219Y, ASP231Y, ASP296Y, ASP328X, ASP369Y, ASP712Y, ASP716Y, CYS230Y, CYS290Y, CYS362Y, CYS395X, GLN259X, GLN320Y, GLN342X, GLN350X, GLN360Y, GLN375Y, GLN386X, GLN402X, GLN673X, GLN673Y, GLN678Y, GLU323X, GLU323Y, GLU348X, GLU397X, GLU546Y, GLU661X, GLY217X, GLY220X, GLY220Y, GLY222X, GLY222Y, GLY226Y, GLY275X, GLY281Y, GLY329Y, GLY361Y, GLY384X, GLY389X, GLY407X, GLY407Y, GLY677Y, GLY719Y, HIS229Y, HIS255X, HIS291Y, HIS359Y, ILE240Y, ILE260X, ILE319X, ILE319Y, ILE333Y, ILE373Y, ILE671X, LEU249Y, LEU256X, LEU337X, LEU337Y, LEU381X, LEU396X, LEU404X, LEU720Y, LYS258X, LYS258Y, LYS322Y, LYS650X, LYS666X, LYS707Y, MET372Y, MET403X, PHE274X, PHE292Y, PHE317Y, PHE344X, PHE366Y, PHE371Y, PHE393X, PHE399X, PHE410X, PHE662X, PHE667X, PHE670X, PHE713Y, PRO250Y, PRO279X, PRO294Y, PRO364Y, PRO365Y, PRO367Y, PRO374Y, PRO400X, PRO653X, PRO655X, PRO658X, PRO659X, SER225Y, SER232Y, SER243Y, SER261X, SER277X, SER293Y, SER339X, SER385X, SER391X, SER392X, SER401X, SER663X, SER669X, SER675Y, SER703Y, SER708Y, THR233Y, THR241Y, THR242Y, THR244Y, THR246Y, THR251Y, THR278X, THR325X, THR325Y, THR326X, THR326Y, THR331Y, THR332Y, THR338X, THR340X, THR380X, THR406X, THR406Y, THR652X, THR665X, THR672X, THR672Y, THR676Y, THR702Y, THR714Y, THR722Y, TRP228Y, TRP234Y, TRP247Y, TRP280X, TRP297Y, TYR252Y, TYR257X, TYR276X, TYR282Y, TYR376Y, TYR378X, TYR394X, TYR398X, TYR674Y, TYR705Y, TYR721Y, VAL221X, VAL221Y, VAL321X, VAL321Y, VAL324Y, VAL330Y, VAL341X, VAL343X, VAL370Y, VAL388X, VAL654X, VAL711Y, VAL715Y
• X-Z: ALA664X, ARG465Z, ASN436Z, ASP440Z, GLN441Z, GLU661X, ILE439Z, LEU438Z, PHE662X, SER663X, THR665X, TYR442Z
• Y-Z: ALA267Y, ALA358Y, ALA426Z, ALA456Z, ALA469Z, ALA506Y, ALA523Y, ALA525Z, ALA548Y, ALA550Y, ALA554Y, ALA568Z, ALA573Y, ALA581Z, ALA592Z, ALA601Y, ALA601Z, ALA620Y, ARG287Y, ARG390Y, ARG433Z, ARG448Z, ARG465Z, ARG485Y, ARG485Z, ARG488Y, ARG514Y, ARG576Y, ARG576Z, ARG610Y, ARG610Z, ARG694Z, ARG730Z, ARG734Z, ASN253Y, ASN269Y, ASN271Y, ASN286Y, ASN302Z, ASN382Y, ASN383Y, ASN436Z, ASN447Z, ASN451Z, ASN458Z, ASN477Z, ASN496Y, ASN497Y, ASN498Y, ASN500Y, ASN510Y, ASN510Z, ASN512Y, ASN519Y, ASN552Y, ASN557Y, ASN570Y, ASN570Z, ASN583Z, ASN691Z, ASN696Z, ASP270Y, ASP284Y, ASP346Y, ASP432Z, ASP440Z, ASP460Z, ASP495Y, ASP529Z, ASP530Z, ASP556Y, ASP590Z, ASP595Y, ASP595Z, ASP609Y, ASP609Z, ASP611Z, ASP626Y, CYS362Y, CYS395Y, CYS483Y, GLN350Y, GLN360Y, GLN375Y, GLN386Y, GLN429Z, GLN441Z, GLN450Z, GLN452Z, GLN457Z, GLN474Z, GLN486Y, GLN487Y, GLN585Z, GLN608Y, GLN608Z, GLN615Y, GLN646Y, GLN688Z, GLN700Z, GLU348Y, GLU397Y, GLU515Y, GLU546Y, GLU564Z, GLU565Z, GLU575Y, GLU575Z, GLU698Z, GLY266Y, GLY275Y, GLY281Y, GLY306Z, GLY356Y, GLY361Y, GLY377Y, GLY384Y, GLY389Y, GLY466Z, GLY470Z, GLY481Y, GLY481Z, GLY505Y, GLY513Y, GLY521Y, GLY539Y, GLY544Y, GLY549Y, GLY578Z, GLY594Z, GLY600Y, GLY600Z, GLY604Z, GLY616Y, GLY627Y, GLY627Z, GLY636Y, GLY637Y, GLY637Z, GLY639Y, HIS272Y, HIS289Y, HIS359Y, HIS422Z, HIS427Z, HIS527Z, HIS597Y, HIS597Z, HIS624Y, HIS628Y, HIS628Z, HIS630Y, HIS630Z, ILE260Y, ILE373Y, ILE439Z, ILE517Y, ILE518Y, ILE542Y, ILE560Y, ILE566Z, ILE618Y, ILE622Y, LEU351Y, LEU355Y, LEU379Y, LEU381Y, LEU396Y, LEU431Z, LEU434Z, LEU438Z, LEU443Z, LEU446Z, LEU461Z, LEU462Z, LEU479Z, LEU511Y, LEU555Y, LEU584Y, LEU584Z, LEU602Y, LEU602Z, LEU634Y, LEU640Y, LEU732Z, LEU736Z, LYS258Y, LYS459Z, LYS476Z, LYS491Y, LYS493Y, LYS508Y, LYS528Y, LYS528Z, LYS531Y, LYS531Z, LYS533Y, LYS545Y, LYS567Z, LYS621Y, LYS693Z, MET435Z, MET471Z, MET524Y, MET537Y, MET541Y, MET559Y, MET599Y, MET599Z, MET605Y, MET605Z, MET635Y, PHE274Y, PHE288Y, PHE344Y, PHE393Y, PHE399Y, PHE421Z, PHE463Z, PHE501Y, PHE534Y, PHE535Y, PHE543Y, PHE577Z, PHE629Y, PHE629Z, PHE638Y, PRO279Y, PRO352Y, PRO374Y, PRO400Y, PRO420Z, PRO437Z, PRO468Z, PRO475Z, PRO480Z, PRO482Y, PRO482Z, PRO520Y, PRO536Y, PRO571Z, PRO591Z, PRO603Y, PRO603Z, PRO617Y, PRO623Y, PRO631Y, PRO633Y, PRO697Z, PRO735Z, SER261Y, SER262Y, SER268Y, SER277Y, SER357Y, SER385Y, SER391Y, SER392Y, SER423Z, SER424Z, SER428Z, SER430Z, SER464Z, SER467Z, SER472Z, SER490Y, SER499Y, SER507Y, SER516Y, SER538Y, SER547Y, SER551Y, SER586Z, SER587Z, SER588Z, SER632Y, SER632Z, SER692Z, THR265Y, THR278Y, THR380Y, THR449Z, THR492Y, THR494Y, THR502Y, THR504Y, THR522Y, THR553Y, THR561Y, THR569Z, THR574Y, THR574Z, THR579Z, THR589Z, THR593Z, THR625Y, THR729Z, THR733Z, TRP280Y, TRP305Z, TRP478Z, TRP503Y, TRP607Y, TRP607Z, TRP619Y, TRP695Z, TYR252Y, TYR273Y, TYR276Y, TYR282Y, TYR349Y, TYR353Y, TYR376Y, TYR378Y, TYR394Y, TYR398Y, TYR425Z, TYR442Z, TYR444Z, TYR445Z, TYR484Y, TYR509Y, TYR613Y, TYR701Z, TYR731Z, VAL354Y, VAL388Y, VAL473Z, VAL489Y, VAL540Y, VAL558Y, VAL572Y, VAL572Z, VAL580Z, VAL582Z, VAL596Y, VAL596Z, VAL598Y, VAL598Z, VAL606Z, VAL699Z
• Z-a: ALA218Z, ALA224a, ALA248a, ALA263Z, ALA334Z, ALA334a, ALA368a, ALA387Z, ALA548a, ALA656Z, ALA660Z, ALA664Z, ALA668Z, ALA706a, ALA709a, ARG245a, ARG287a, ARG295a, ARG299a, ARG390Z, ARG405Z, ARG405a, ASN223Z, ASN223a, ASN227a, ASN253Z, ASN253a, ASN254a, ASN318a, ASN327Z, ASN335Z, ASN335a, ASN336Z, ASN336a, ASN382Z, ASN383Z, ASN408Z, ASN408a, ASN409Z, ASN651a, ASN657Z, ASN704a, ASN710a, ASN717a, ASN718a, ASP219Z, ASP219a, ASP231a, ASP296a, ASP328Z, ASP369a, ASP712a, ASP716a, CYS230a, CYS290a, CYS362a, CYS395Z, GLN259Z, GLN320a, GLN342Z, GLN350Z, GLN360a, GLN375a, GLN386Z, GLN402Z, GLN673Z, GLN673a, GLN678a, GLU323Z, GLU323a, GLU348Z, GLU397Z, GLU546a, GLU661Z, GLY217Z, GLY220Z, GLY220a, GLY222Z, GLY222a, GLY226a, GLY275Z, GLY281a, GLY329a, GLY361a, GLY384Z, GLY389Z, GLY407Z, GLY407a, GLY677a, GLY719a, HIS229a, HIS255Z, HIS291a, HIS359a, ILE240a, ILE260Z, ILE319a, ILE333a, ILE373a, ILE671Z, LEU249a, LEU256Z, LEU337Z, LEU337a, LEU381Z, LEU396Z, LEU404Z, LEU720a, LYS258Z, LYS258a, LYS322a, LYS650Z, LYS666Z, LYS707a, MET372a, MET403Z, PHE274Z, PHE292a, PHE317a, PHE344Z, PHE366a, PHE371a, PHE393Z, PHE399Z, PHE410Z, PHE662Z, PHE667Z, PHE670Z, PHE713a, PRO250a, PRO279Z, PRO294a, PRO364a, PRO365a, PRO367a, PRO374a, PRO400Z, PRO653Z, PRO655Z, PRO658Z, PRO659Z, SER225a, SER232a, SER243a, SER261Z, SER277Z, SER293a, SER339Z, SER385Z, SER391Z, SER392Z, SER401Z, SER663Z, SER669Z, SER675a, SER703a, SER708a, THR233a, THR241a, THR242a, THR244a, THR246a, THR251a, THR278Z, THR325Z, THR325a, THR326Z, THR326a, THR331a, THR332a, THR338Z, THR340Z, THR380Z, THR406Z, THR406a, THR652Z, THR665Z, THR672Z, THR672a, THR676a, THR702a, THR714a, THR722a, TRP228a, TRP234a, TRP247a, TRP280Z, TRP297a, TYR252a, TYR257Z, TYR276Z, TYR282a, TYR376a, TYR378Z, TYR394Z, TYR398Z, TYR674a, TYR705a, TYR721a, VAL221Z, VAL221a, VAL239a, VAL321Z, VAL321a, VAL324a, VAL330a, VAL341Z, VAL343Z, VAL370a, VAL388Z, VAL654Z, VAL711a, VAL715a
• Z-b: ARG405Z, GLY222b, LEU337Z, LEU337b, THR338Z
• Z-c: ARG405c, GLY222Z, LEU337Z, LEU337c, THR338c
• Z-d: ALA218d, ALA224Z, ALA248Z, ALA263d, ALA334Z, ALA334d, ALA368Z, ALA387d, ALA548Z, ALA656d, ALA660d, ALA664d, ALA668d, ALA706Z, ALA709Z, ARG245Z, ARG287Z, ARG295Z, ARG299Z, ARG390d, ARG405Z, ARG405d, ASN223Z, ASN223d, ASN227Z, ASN253Z, ASN253d, ASN254Z, ASN318Z, ASN327d, ASN335Z, ASN335d, ASN336Z, ASN336d, ASN382d, ASN383d, ASN408Z, ASN408d, ASN409Z, ASN409d, ASN651Z, ASN657d, ASN704Z, ASN710Z, ASN717Z, ASN718Z, ASP219Z, ASP219d, ASP231Z, ASP296Z, ASP328d, ASP369Z, ASP712Z, ASP716Z, CYS230Z, CYS290Z, CYS362Z, CYS395d, GLN259d, GLN320Z, GLN342d, GLN350d, GLN360Z, GLN375Z, GLN386d, GLN402d, GLN673Z, GLN673d, GLN678Z, GLU323Z, GLU323d, GLU348d, GLU397d, GLU546Z, GLU661d, GLY217d, GLY220Z, GLY220d, GLY222Z, GLY222d, GLY226Z, GLY275d, GLY281Z, GLY329Z, GLY361Z, GLY384d, GLY389d, GLY407Z, GLY407d, GLY677Z, GLY719Z, HIS229Z, HIS255d, HIS291Z, HIS359Z, ILE240Z, ILE260d, ILE319Z, ILE333Z, ILE373Z, ILE671d, LEU249Z, LEU256d, LEU337Z, LEU337d, LEU381d, LEU396d, LEU404d, LEU720Z, LYS258Z, LYS258d, LYS322Z, LYS650d, LYS666d, LYS707Z, MET372Z, MET403d, PHE274d, PHE292Z, PHE317Z, PHE344d, PHE366Z, PHE371Z, PHE393d, PHE399d, PHE410d, PHE662d, PHE667d, PHE670d, PHE713Z, PRO250Z, PRO279d, PRO294Z, PRO364Z, PRO365Z, PRO367Z, PRO374Z, PRO400d, PRO653d, PRO655d, PRO658d, PRO659d, SER225Z, SER232Z, SER243Z, SER261d, SER277d, SER293Z, SER339d, SER385d, SER391d, SER392d, SER401d, SER663d, SER669d, SER675Z, SER703Z, SER708Z, THR233Z, THR241Z, THR242Z, THR244Z, THR246Z, THR251Z, THR278d, THR325Z, THR325d, THR326Z, THR326d, THR331Z, THR332Z, THR338d, THR340d, THR380d, THR406Z, THR406d, THR652d, THR665d, THR672Z, THR672d, THR676Z, THR702Z, THR714Z, THR722Z, TRP228Z, TRP234Z, TRP247Z, TRP280d, TRP297Z, TYR252Z, TYR257d, TYR276d, TYR282Z, TYR376Z, TYR378d, TYR394d, TYR398d, TYR674Z, TYR705Z, TYR721Z, VAL221Z, VAL221d, VAL321Z, VAL321d, VAL324Z, VAL330Z, VAL341d, VAL343d, VAL370Z, VAL388d, VAL654d, VAL711Z, VAL715Z
• a-b: ALA218a, ALA224b, ALA248b, ALA263a, ALA334a, ALA334b, ALA368b, ALA387a, ALA548b, ALA656a, ALA660a, ALA664a, ALA668a, ALA706b, ALA709b, ARG245b, ARG287b, ARG295b, ARG299b, ARG390a, ARG405a, ARG405b, ASN223a, ASN223b, ASN227b, ASN253a, ASN253b, ASN254b, ASN318b, ASN327a, ASN335a, ASN335b, ASN336a, ASN336b, ASN382a, ASN383a, ASN408a, ASN408b, ASN409a, ASN651b, ASN657a, ASN704b, ASN710b, ASN717b, ASN718b, ASP219a, ASP219b, ASP231b, ASP296b, ASP328a, ASP369b, ASP712b, ASP716b, CYS230b, CYS290b, CYS362b, CYS395a, GLN259a, GLN320b, GLN342a, GLN350a, GLN360b, GLN375b, GLN386a, GLN402a, GLN673a, GLN673b, GLN678b, GLU323a, GLU323b, GLU348a, GLU397a, GLU546b, GLU661a, GLY217a, GLY220a, GLY220b, GLY222a, GLY222b, GLY226b, GLY275a, GLY281b, GLY329b, GLY361b, GLY384a, GLY389a, GLY407a, GLY407b, GLY677b, GLY719b, HIS229b, HIS255a, HIS291b, HIS359b, ILE240b, ILE260a, ILE319a, ILE319b, ILE333b, ILE373b, ILE671a, LEU249b, LEU256a, LEU337a, LEU337b, LEU381a, LEU396a, LEU404a, LEU720b, LYS258a, LYS258b, LYS322b, LYS650a, LYS666a, LYS707b, MET372b, MET403a, PHE274a, PHE292b, PHE317b, PHE344a, PHE366b, PHE371b, PHE393a, PHE399a, PHE410a, PHE662a, PHE667a, PHE670a, PHE713b, PRO250b, PRO279a, PRO294b, PRO364b, PRO365b, PRO367b, PRO374b, PRO400a, PRO653a, PRO655a, PRO658a, PRO659a, SER225b, SER232b, SER243b, SER261a, SER277a, SER293b, SER339a, SER385a, SER391a, SER392a, SER401a, SER663a, SER669a, SER675b, SER703b, SER708b, THR233b, THR241b, THR242b, THR244b, THR246b, THR251b, THR278a, THR325a, THR325b, THR326a, THR326b, THR331b, THR332b, THR338a, THR340a, THR380a, THR406a, THR406b, THR652a, THR665a, THR672a, THR672b, THR676b, THR702b, THR714b, THR722b, TRP228b, TRP234b, TRP247b, TRP280a, TRP297b, TYR252b, TYR257a, TYR276a, TYR282b, TYR376b, TYR378a, TYR394a, TYR398a, TYR674b, TYR705b, TYR721b, VAL221a, VAL221b, VAL239b, VAL321a, VAL321b, VAL324b, VAL330b, VAL341a, VAL343a, VAL370b, VAL388a, VAL654a, VAL711b, VAL715b
• a-c: ARG405a, GLY222c, LEU337a, LEU337c, THR338a
• a-d: ARG405d, GLY222a, LEU337a, LEU337d, THR338d
• b-c: ALA218b, ALA224c, ALA248c, ALA263b, ALA334b, ALA334c, ALA368c, ALA387b, ALA548c, ALA656b, ALA660b, ALA664b, ALA668b, ALA706c, ALA709c, ARG245c, ARG287c, ARG295c, ARG299c, ARG390b, ARG405b, ARG405c, ASN223b, ASN223c, ASN227c, ASN253b, ASN253c, ASN254c, ASN318c, ASN327b, ASN335b, ASN335c, ASN336b, ASN336c, ASN382b, ASN383b, ASN408b, ASN408c, ASN409b, ASN409c, ASN651c, ASN657b, ASN704c, ASN710c, ASN717c, ASN718c, ASP219b, ASP219c, ASP231c, ASP296c, ASP328b, ASP369c, ASP712c, ASP716c, CYS230c, CYS290c, CYS362c, CYS395b, GLN259b, GLN320c, GLN342b, GLN350b, GLN360c, GLN375c, GLN386b, GLN402b, GLN673b, GLN673c, GLN678c, GLU323b, GLU323c, GLU348b, GLU397b, GLU546c, GLU661b, GLY217b, GLY220b, GLY220c, GLY222b, GLY222c, GLY226c, GLY275b, GLY281c, GLY329c, GLY361c, GLY384b, GLY389b, GLY407b, GLY407c, GLY677c, GLY719c, HIS229c, HIS255b, HIS291c, HIS359c, ILE240c, ILE260b, ILE319c, ILE333c, ILE373c, ILE671b, LEU249c, LEU256b, LEU337b, LEU337c, LEU381b, LEU396b, LEU404b, LEU720c, LYS258b, LYS258c, LYS322c, LYS650b, LYS666b, LYS707c, MET372c, MET403b, PHE274b, PHE292c, PHE317c, PHE344b, PHE366c, PHE371c, PHE393b, PHE399b, PHE410b, PHE662b, PHE667b, PHE670b, PHE713c, PRO250c, PRO279b, PRO294c, PRO364c, PRO365c, PRO367c, PRO374c, PRO400b, PRO653b, PRO655b, PRO658b, PRO659b, SER225c, SER232c, SER243c, SER261b, SER277b, SER293c, SER339b, SER385b, SER391b, SER392b, SER401b, SER547c, SER663b, SER669b, SER675c, SER703c, SER708c, THR233c, THR241c, THR242c, THR244c, THR246c, THR251c, THR278b, THR325b, THR325c, THR326b, THR326c, THR331c, THR332c, THR338b, THR340b, THR380b, THR406b, THR406c, THR652b, THR665b, THR672b, THR672c, THR676c, THR702c, THR714c, THR722c, TRP228c, TRP234c, TRP247c, TRP280b, TRP297c, TYR252c, TYR257b, TYR276b, TYR282c, TYR376c, TYR378b, TYR394b, TYR398b, TYR674c, TYR705c, TYR721c, VAL221b, VAL221c, VAL321b, VAL321c, VAL324c, VAL330c, VAL341b, VAL343b, VAL370c, VAL388b, VAL654b, VAL711c, VAL715c
• b-d: ARG405b, GLY222d, LEU337b, LEU337d, THR338b
• c-d: ALA218c, ALA224d, ALA248d, ALA263c, ALA334c, ALA334d, ALA368d, ALA387c, ALA548d, ALA656c, ALA660c, ALA664c, ALA668c, ALA706d, ALA709d, ARG245d, ARG287d, ARG295d, ARG299d, ARG390c, ARG405c, ARG405d, ASN223c, ASN223d, ASN227d, ASN253c, ASN253d, ASN254d, ASN318d, ASN327c, ASN335c, ASN335d, ASN336c, ASN336d, ASN382c, ASN383c, ASN408c, ASN408d, ASN409c, ASN409d, ASN651d, ASN657c, ASN704d, ASN710d, ASN717d, ASN718d, ASP219c, ASP219d, ASP231d, ASP296d, ASP328c, ASP369d, ASP712d, ASP716d, CYS230d, CYS290d, CYS362d, CYS395c, GLN259c, GLN320d, GLN342c, GLN350c, GLN360d, GLN375d, GLN386c, GLN402c, GLN673c, GLN673d, GLN678d, GLU323c, GLU323d, GLU348c, GLU397c, GLU546d, GLU661c, GLY217c, GLY220c, GLY220d, GLY222c, GLY222d, GLY226d, GLY275c, GLY281d, GLY329d, GLY361d, GLY384c, GLY389c, GLY407c, GLY407d, GLY677d, GLY719d, HIS229d, HIS255c, HIS291d, HIS359d, ILE240d, ILE260c, ILE319c, ILE319d, ILE333d, ILE373d, ILE671c, LEU249d, LEU256c, LEU337c, LEU337d, LEU381c, LEU396c, LEU404c, LEU720d, LYS258c, LYS258d, LYS322d, LYS650c, LYS666c, LYS707d, MET372d, MET403c, PHE274c, PHE292d, PHE317d, PHE344c, PHE366d, PHE371d, PHE393c, PHE399c, PHE410c, PHE662c, PHE667c, PHE670c, PHE713d, PRO250d, PRO279c, PRO294d, PRO364d, PRO365d, PRO367d, PRO374d, PRO400c, PRO653c, PRO655c, PRO658c, PRO659c, SER225d, SER232d, SER243d, SER261c, SER277c, SER293d, SER339c, SER385c, SER391c, SER392c, SER401c, SER663c, SER669c, SER675d, SER703d, SER708d, THR233d, THR241d, THR242d, THR244d, THR246d, THR251d, THR278c, THR325c, THR325d, THR326c, THR326d, THR331d, THR332d, THR338c, THR340c, THR380c, THR406c, THR406d, THR652c, THR665c, THR672c, THR672d, THR676d, THR702d, THR714d, THR722d, TRP228d, TRP234d, TRP247d, TRP280c, TRP297d, TYR252d, TYR257c, TYR276c, TYR282d, TYR376d, TYR378c, TYR394c, TYR398c, TYR674d, TYR705d, TYR721d, VAL221c, VAL221d, VAL321c, VAL321d, VAL324d, VAL330d, VAL341c, VAL343c, VAL370d, VAL388c, VAL654c, VAL711d, VAL715d
• e-f: ALA218e, ALA224f, ALA248f, ALA263e, ALA334e, ALA334f, ALA368f, ALA387e, ALA548f, ALA656e, ALA660e, ALA664e, ALA668e, ALA706f, ALA709f, ARG245f, ARG287f, ARG295f, ARG299f, ARG390e, ARG405e, ARG405f, ASN223e, ASN223f, ASN227f, ASN253e, ASN253f, ASN254f, ASN318f, ASN327e, ASN335e, ASN335f, ASN336e, ASN336f, ASN382e, ASN383e, ASN408e, ASN408f, ASN409e, ASN409f, ASN651f, ASN657e, ASN704f, ASN710f, ASN717f, ASN718f, ASP219e, ASP219f, ASP231f, ASP296f, ASP328e, ASP369f, ASP712f, ASP716f, CYS230f, CYS290f, CYS362f, CYS395e, GLN259e, GLN320f, GLN342e, GLN350e, GLN360f, GLN375f, GLN386e, GLN402e, GLN673e, GLN673f, GLN678f, GLU323e, GLU323f, GLU348e, GLU397e, GLU546f, GLU661e, GLY217e, GLY220e, GLY220f, GLY222e, GLY222f, GLY226f, GLY275e, GLY281f, GLY329f, GLY361f, GLY384e, GLY389e, GLY407e, GLY407f, GLY677f, GLY719f, HIS229f, HIS255e, HIS291f, HIS359f, ILE240f, ILE260e, ILE319e, ILE319f, ILE333f, ILE373f, ILE671e, LEU249f, LEU256e, LEU337e, LEU337f, LEU381e, LEU396e, LEU404e, LEU720f, LYS258e, LYS258f, LYS322f, LYS650e, LYS666e, LYS707f, MET372f, MET403e, PHE274e, PHE292f, PHE317f, PHE344e, PHE366f, PHE371f, PHE393e, PHE399e, PHE410e, PHE662e, PHE667e, PHE670e, PHE713f, PRO250f, PRO279e, PRO294f, PRO364f, PRO367f, PRO374f, PRO400e, PRO653e, PRO655e, PRO658e, PRO659e, SER225f, SER232f, SER243f, SER261e, SER277e, SER293f, SER339e, SER385e, SER391e, SER392e, SER401e, SER663e, SER669e, SER675f, SER703f, SER708f, THR233f, THR241f, THR242f, THR244f, THR246f, THR251f, THR278e, THR325e, THR325f, THR326e, THR326f, THR331f, THR332e, THR332f, THR338e, THR340e, THR380e, THR406e, THR406f, THR652e, THR665e, THR672e, THR672f, THR676f, THR702f, THR714f, THR722f, TRP228f, TRP234f, TRP247f, TRP280e, TRP297f, TYR252f, TYR257e, TYR276e, TYR282f, TYR376f, TYR378e, TYR394e, TYR398e, TYR674f, TYR705f, TYR721f, VAL221e, VAL221f, VAL239f, VAL321e, VAL321f, VAL324f, VAL330f, VAL341e, VAL343e, VAL370f, VAL388e, VAL654e, VAL711f, VAL715f
• e-g: ARG405e, GLY222g, LEU337e, LEU337g, THR338e, VAL221g
• e-i: ALA387i, ARG245e, ARG405i, ASN335e, ASP219e, ASP219i, ASP369e, ASP716e, GLU397i, GLY222e, GLY389i, GLY407i, GLY719e, ILE319e, LYS258i, LYS666i, PRO655i, SER401i, SER708e, THR338i, TRP228e, TYR674e, TYR705e, VAL221e
• e-j: ARG295e, ARG295j, ARG299e, ARG299j, ARG694e, ARG694j, ASN303e, ASN303j, ASP231e, ASP231j, ASP529e, ASP529j, ASP530e, ASP530j, GLN298e, GLN298j, GLN700e, GLU690e, GLU690j, GLU698e, GLU698j, LYS693e, LYS693j, LYS707e, LYS707j, THR702j, TRP695e, TRP695j
• e-n: ALA358n, ALA550n, ALA601e, ALA601n, ARG390n, ARG433e, ARG465e, ARG514n, ARG576e, ARG694e, ARG734e, ASN271n, ASN436e, ASN447e, ASN477e, ASN497n, ASN498n, ASN500n, ASN510n, ASN583e, ASP270n, ASP346n, ASP432e, ASP440e, ASP460e, ASP495n, ASP529e, ASP609e, ASP611e, ASP626n, GLN360n, GLN375n, GLN450e, GLN487n, GLN585e, GLU348n, GLU515n, GLU564e, GLU565e, GLU575e, GLU698e, GLY356n, GLY389n, GLY549n, GLY604e, GLY627n, HIS272n, HIS359n, HIS422e, HIS427e, HIS624n, HIS628n, HIS630e, ILE517n, ILE542n, LEU634n, LEU736e, LYS459e, LYS493n, LYS508n, LYS528e, LYS693e, MET605e, MET635n, PHE393n, PHE463e, PHE577e, PHE629n, SER391n, SER392n, SER472e, SER499n, SER587e, THR449e, THR494n, THR502n, THR553n, THR579e, TRP607e, TRP695e, TYR398n, TYR442e, TYR444e, TYR484n
• f-g: ALA218f, ALA224g, ALA248g, ALA334f, ALA334g, ALA368g, ALA387f, ALA656f, ALA660f, ALA664f, ALA668f, ARG245g, ARG287g, ARG295g, ARG299g, ARG405f, ARG405g, ASN223f, ASN223g, ASN227g, ASN253g, ASN254g, ASN318g, ASN327f, ASN335f, ASN335g, ASN336f, ASN336g, ASN408f, ASN408g, ASN409f, ASN657f, ASP219f, ASP219g, ASP231g, ASP296g, ASP328f, ASP369g, ASP716g, CYS230g, CYS290g, CYS362g, CYS395f, GLN259f, GLN320g, GLN342f, GLN350f, GLN360g, GLN375g, GLN402f, GLN673f, GLU323f, GLU323g, GLU348f, GLU397f, GLU546g, GLU661f, GLY217f, GLY220f, GLY220g, GLY222f, GLY222g, GLY226g, GLY281g, GLY329g, GLY361g, GLY389f, GLY407f, GLY407g, GLY719g, HIS229g, HIS255f, HIS291g, HIS359g, ILE240g, ILE319f, ILE319g, ILE333g, ILE373g, ILE671f, LEU249g, LEU256f, LEU337f, LEU337g, LEU396f, LEU404f, LYS258f, LYS258g, LYS322g, LYS650f, LYS666f, MET372g, MET403f, PHE292g, PHE317g, PHE344f, PHE366g, PHE371g, PHE393f, PHE399f, PHE410f, PHE662f, PHE667f, PHE670f, PRO250g, PRO279f, PRO294g, PRO364g, PRO365g, PRO367g, PRO374g, PRO400f, PRO653f, PRO655f, PRO658f, PRO659f, SER225g, SER232g, SER243g, SER293g, SER339f, SER392f, SER401f, SER663f, SER669f, SER708g, THR233g, THR241g, THR242g, THR244g, THR246g, THR251g, THR278f, THR325f, THR325g, THR326f, THR326g, THR331g, THR332f, THR332g, THR338f, THR340f, THR406f, THR406g, THR652f, THR665f, THR672f, TRP228g, TRP234g, TRP247g, TRP280f, TRP297g, TYR252g, TYR257f, TYR282g, TYR376g, TYR378f, TYR394f, TYR398f, TYR705g, VAL221f, VAL221g, VAL239g, VAL321f, VAL321g, VAL324g, VAL330g, VAL341f, VAL343f, VAL370g, VAL654f
• g-h: ALA387g, ARG245h, ARG405g, ASN227h, ASP219g, ASP219h, ASP369h, ASP716h, GLN259g, GLU397g, GLY222h, GLY389g, GLY407g, GLY719h, ILE319h, LYS258g, LYS666g, MET403g, PRO655g, SER401g, SER708h, THR406h, TRP228h, TYR674h, TYR705h, VAL221h
• h-i: ALA387h, ARG245i, ARG405h, ASN227i, ASP219h, ASP219i, ASP369i, ASP716i, GLN259h, GLU397h, GLU546i, GLY222i, GLY389h, GLY407h, GLY719i, ILE319i, LYS258h, LYS666h, MET403h, PRO655h, SER401h, SER708i, THR406i, TRP228i, TYR674i, TYR705i, VAL221i
• i-j: ALA358i, ALA550i, ALA601i, ALA601j, ARG390i, ARG433j, ARG465j, ARG514i, ARG576j, ARG694j, ARG734j, ASN271i, ASN436j, ASN447j, ASN477j, ASN497i, ASN498i, ASN500i, ASN510i, ASN583j, ASP270i, ASP346i, ASP432j, ASP440j, ASP460j, ASP495i, ASP529j, ASP609j, ASP611j, ASP626i, GLN360i, GLN375i, GLN450j, GLN487i, GLN585j, GLU348i, GLU515i, GLU564j, GLU565j, GLU575j, GLU698j, GLY356i, GLY389i, GLY604j, GLY627i, HIS272i, HIS359i, HIS422j, HIS427j, HIS624i, HIS628i, HIS630j, ILE517i, ILE542i, LEU634i, LEU736j, LYS459j, LYS493i, LYS508i, LYS528j, LYS693j, MET605j, MET635i, PHE393i, PHE463j, PHE577j, PHE629i, SER391i, SER472j, SER499i, SER587j, THR449j, THR494i, THR502i, THR553i, THR579j, TRP607j, TRP695j, TYR398i, TYR442j, TYR444j, TYR484i
• j-k: ALA387j, ARG245k, ARG405j, ASP219j, ASP219k, ASP369k, ASP716k, GLN259j, GLU397j, GLY222k, GLY389j, GLY407j, GLY719k, ILE319k, LYS258j, LYS666j, PRO655j, SER401j, SER708k, THR406k, TRP228k, TYR674k, TYR705k
• j-n: ALA387n, ARG245j, ARG405n, ASN335j, ASP219j, ASP219n, ASP369j, ASP716j, GLN259n, GLU397n, GLY222j, GLY389n, GLY407n, GLY719j, ILE319j, LYS258n, LYS666n, PRO655n, SER401n, SER708j, THR338n, THR406j, TRP228j, TYR674j, TYR705j, VAL221j
• k-l: ALA387k, ARG245l, ARG405k, ASP219k, ASP219l, ASP369l, ASP716l, GLN259k, GLU397k, GLY222l, GLY389k, GLY407k, GLY719l, LYS258k, LYS666k, PRO655k, SER401k, SER708l, THR406l, TRP228l, TYR674l, TYR705l
• l-m: ALA387l, ARG245m, ARG405l, ASP219l, ASP219m, ASP369m, ASP716m, GLN259l, GLU397l, GLU546m, GLY222m, GLY389l, GLY407l, GLY719m, ILE319m, LYS258l, LYS666l, SER401l, SER708m, THR406m, TRP228m, TYR705m, VAL221m
• m-n: ALA387m, ARG245n, ARG405m, ASN227n, ASP219m, ASP219n, ASP369n, ASP716n, GLN259m, GLU397m, GLU546n, GLY222n, GLY389m, GLY407m, GLY719n, ILE319n, LYS258m, LYS666m, MET403m, PRO655m, SER401m, SER708n, THR406n, TRP228n, TYR674n, TYR705n, VAL221n