1VSY

proteasome activator complex

• Total interactions analyzed: 561
• Total true interactions: 102
• Strongest Interaction:
  • Chains: A-I
  • Int. Res.: 61
  • Norm. En. per Res.: -4.4756
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-70.053	-11.6932	-359.205	-440.9511	122	24	10	14000	2	21	26
A-G	-51.068	-34.8215	-368.924	-454.8135	131	15	9	14494	2	26	26
A-H	-4.2366	-26.4228	-83.9075	-114.5669	47	3	4	3618	2	12	16
A-I	-20.3715	-78.5728	-174.066	-273.0103	61	12	1	6421	9	14	22
A-2	0.0	0.0	-11.4499	-11.4499	15	1	0	563	0	3	4
A-4	-5.849	-61.1213	0.0	-66.9703	15	0	0	0	0	0	0
B-C	-19.9527	-18.3385	-151.772	-190.0632	75	4	4	7006	1	15	12
B-I	-64.1121	-39.2662	-161.813	-265.1913	76	12	3	6369	4	16	17
B-J	0.0	9.0152	-113.811	-104.7958	56	2	2	4753	1	16	22
B-4	0.0	-4.5217	0.0	-4.5217	9	0	0	0	0	0	0
B-5	0.0	-4.962			2
C-D	-46.9995	-6.6009	-284.328	-337.9283	116	21	4	11884	1	24	27
C-I	0.0	16.2095	-8.2438	7.9658	11	0	0	276	0	5	4
C-J	-6.6902	-3.8576	-112.272	-122.8198	50	4	1	4840	0	17	22
C-K	-24.7802	-36.2283	-127.379	-188.3875	50	3	2	4838	4	22	24
C-5	0.0	8.8103			9
D-E	-17.9847	-27.427	-170.289	-215.7007	80	20	4	7584	3	17	14
D-K	-9.1383	-11.8811	-88.618	-109.6374	45	3	3	4045	1	16	13
D-L	-12.5191	-73.9695	-74.178	-160.6666	47	1	1	3362	7	41	28
D-5	-15.8195	-8.2025			25
E-F	-38.1748	-47.4292	-278.458	-364.062	125	14	8	11734	3	38	30
E-L	-23.3519	-37.2133	-91.8405	-152.4057	51	5	1	4181	6	28	28
E-M	-9.9228	-36.1469	-139.831	-185.9006	51	2	0	4681	4	30	25
E-4	0.0	-11.6206	0.0	-11.6206	4	0	0	0	0	0	0
E-5	-15.8011	37.1771			25
F-G	-50.597	-31.7467	-381.328	-463.6717	131	12	11	14875	1	31	33
F-M	-18.2569	-29.2623	-79.8822	-127.4013	41	6	0	3325	3	13	17
F-N	-13.0478	-36.4403	-145.69	-195.1781	56	2	3	5414	2	29	12
F-4	-27.5451	27.3957	0.0	-0.1494	10	0	0	0	0	0	0
F-5	-90.2839	-83.5253			26
G-H	-17.2656	-9.8767	-113.076	-140.2183	51	1	4	4746	0	15	10
G-N	-21.9671	-37.5274	-102.406	-161.9005	56	7	2	4393	7	33	22
G-4	-9.9976	10.7709	0.0	0.7733	7	0	0	0	0	0	0
H-I	-36.2178	-48.5986	-91.553	-176.3694	66	5	3	3957	3	15	5
H-N	-28.9411	-24.0302	-160.582	-213.5533	68	11	1	6836	5	22	18
H-V	-13.3196	-18.509	-188.369	-220.1976	55	6	3	6788	4	12	11
H-2	-92.0821	2.0757	-342.78	-432.7864	115	24	9	14029	3	29	31
I-J	-97.714	-127.7318	-364.551	-589.9968	144	15	14	15415	8	44	35
I-Z	0.0	0.0	-8.9045	-8.9045	7	0	1	478	0	0	0
I-1	-77.2536	-67.7363	-324.112	-469.1018	118	40	6	14342	5	34	38
I-2	-8.2045	-36.2142	-194.546	-238.9647	90	14	5	9052	1	21	21
J-K	-16.8398	-58.213	-121.95	-197.0028	75	9	4	5936	3	12	11
J-Z	-34.9369	-57.6324	-244.888	-337.4573	89	9	4	9596	3	21	20
J-1	-52.4683	-25.8142	-198.491	-276.7735	77	15	1	7868	3	20	21
K-L	-11.1714	-57.5588	-147.521	-216.2512	66	8	4	6433	5	21	22
K-Y	-47.8788	-36.1816	-156.336	-240.3964	54	5	2	6532	2	18	31
K-Z	-29.2353	-45.8789	-210.379	-285.4932	78	18	2	8153	4	20	17
L-M	-43.643	-39.9639	-187.546	-271.1529	88	9	5	6668	3	25	18
L-W	0.0	0.0	-8.6372	-8.6372	7	0	1	480	0	0	0
L-X	-34.3236	-59.4923	-243.121	-336.9369	91	10	4	9640	4	21	20
L-Y	-35.4517	-46.0286	-207.908	-289.3884	78	15	2	8193	5	21	17
M-N	-18.3264	-90.65	-258.542	-367.5184	98	8	6	10104	9	29	24
M-W	-76.4152	-68.889	-328.383	-473.6872	118	40	6	14496	5	34	39
M-X	-52.8213	-26.0606	-184.671	-263.5529	78	15	1	7908	3	20	21
N-O	0.0	0.0	-11.185	-11.185	16	1	0	561	0	3	4
N-V	-88.9106	2.9979	-342.931	-428.8437	113	21	9	13980	3	29	31
N-W	-23.1881	-37.5622	-196.332	-257.0822	90	12	5	9059	1	21	21
O-P	-77.5702	-11.8444	-358.048	-447.4626	122	25	10	14064	2	21	25
O-U	-50.3047	-34.7041	-371.376	-456.3848	129	13	9	14477	2	26	26
O-V	-4.6794	-27.4849	-86.6439	-118.8082	47	1	4	3662	2	12	16
O-W	-13.0486	-78.1717	-171.879	-263.0993	60	10	1	6362	9	14	22
O-7	-5.9068	-60.7269			15
P-Q	-26.036	-17.713	-148.988	-192.737	75	6	4	6997	1	15	12
P-W	-49.7468	-39.645	-163.86	-253.2518	77	8	3	6387	4	16	17
P-X	-12.3298	8.4968	-110.85	-114.683	54	4	2	4755	1	16	22
P-7	0.0	-4.8297			9
P-8	0.0	-5.1228			2
Q-R	-47.3633	-6.2791	-284.269	-337.9114	115	21	4	11895	1	24	27
Q-W	0.0	16.1182	-7.8657	8.2525	11	0	0	271	0	5	4
Q-X	-6.0012	-3.795	-109.372	-119.1681	49	3	1	4781	0	17	22
Q-Y	-24.0464	-35.9772	-127.909	-187.9326	49	3	2	4827	4	22	24
Q-8	0.0	8.8019			9
R-S	-12.6095	-27.3855	-167.005	-207.0	80	14	4	7551	3	17	14
R-Y	-9.1897	-12.7628	-86.9419	-108.8944	44	3	3	4000	1	16	13
R-Z	-12.3078	-74.8917	-74.9237	-162.1232	47	1	1	3372	7	41	28
R-8	-23.5478	-24.5005			26
S-T	-48.2694	-49.1021	-282.378	-379.7495	128	17	8	11799	3	38	30
S-Z	-23.5015	-38.2993	-93.381	-155.1819	50	7	1	4226	6	28	28
S-1	0.0	-32.3307	-137.071	-169.4017	53	2	0	4649	4	30	25
S-7	0.0	-11.917			4
S-8	-20.3926	36.4902			27
T-U	-56.9439	-31.6358	-382.646	-471.2257	133	14	11	14928	1	31	35
T-1	-16.0877	-39.5038	-79.0432	-134.6346	42	7	0	3348	4	13	17
T-2	-11.6242	-36.7367	-139.256	-187.6169	55	0	3	5274	2	28	12
T-7	-19.5146	27.577			8
T-8	-85.2398	-82.178			26
U-V	-15.6879	-9.673	-107.969	-133.3299	53	2	4	4665	0	15	10
U-2	-21.7039	-36.5253	-104.802	-163.0313	55	5	2	4445	6	33	22
U-7	-5.529	9.7428			5
V-W	-34.2381	-48.2695	-90.3967	-172.9043	65	6	3	3948	3	15	5
V-2	-29.191	-24.2796	-161.281	-214.7516	69	10	1	6838	6	22	18
W-X	-94.2379	-127.1348	-362.415	-583.7877	144	15	14	15390	8	44	35
X-Y	-15.9147	-58.6466	-120.881	-195.4423	76	10	4	6001	3	13	11
Y-Z	-14.2674	-57.2898	-146.876	-218.4332	67	12	4	6461	5	21	22
Z-1	-52.8123	-39.9532	-186.571	-279.3365	92	9	5	6713	3	25	18
1-2	-26.2615	-92.178	-259.016	-377.4555	99	15	6	10310	10	29	24
3-4	-34.3186	-116.5791	-241.207	-392.1047	94	15	9	10675	2	20	24
3-5	-13.6976	-20.0142			11
4-5	-91.7477	-128.0762			81
6-7	-35.6013	-114.6451			17
6-8	-24.7201	-19.9389			13
7-8	-101.3065	-133.7482			81

Interface residues

• A-B: ALA1044A, ALA1118A, ALA1122A, ALA1132A, ALA1160A, ALA1168A, ALA1170A, ALA2024B, ALA2027B, ALA2056B, ALA2121B, ARG1024A, ARG1046A, ARG1120A, ARG1131A, ARG2083B, ARG2090B, ARG2128B, ASN1123A, ASN1181A, ASN1184A, ASP1013A, ASP1115A, ASP1158A, ASP1192A, ASP2022B, ASP2081B, ASP2087B, GLN1126A, GLN1130A, GLN1175A, GLN1176A, GLN2020B, GLN2030B, GLU1022A, GLU1183A, GLU2059B, GLY1023A, GLY1161A, GLY1165A, GLY2079B, GLY2125B, GLY2126B, GLY2131B, HIS1185A, ILE1016A, ILE1018A, ILE1127A, ILE1154A, ILE1178A, ILE1191A, ILE2021B, LEU1025A, LEU1043A, LEU1124A, LEU1150A, LEU1182A, LEU2025B, LEU2055B, LEU2061B, LEU2085B, LYS1107A, LYS1119A, LYS1156A, LYS1167A, LYS1187A, LYS2029B, LYS2049B, LYS2050B, LYS2063B, LYS2088B, LYS2091B, MET1121A, MET1134A, MET2057B, MET2078B, MET2118B, PHE1019A, PHE1186A, PHE2130B, PRO1021A, PRO1152A, PRO1159A, PRO2054B, PRO2080B, PRO2129B, PRO2152B, SER1020A, SER1125A, SER1153A, SER2051B, SER2052B, SER2053B, SER2058B, SER2062B, SER2065B, SER2124B, THR1017A, THR1129A, THR1157A, THR1169A, THR1179A, THR1180A, THR2026B, THR2060B, TYR1128A, TYR1133A, TYR1155A, TYR1162A, TYR1163A, TYR1166A, TYR2023B, TYR2075B, TYR2082B, VAL1028A, VAL1045A, VAL1164A, VAL2028B, VAL2084B, VAL2086B, VAL2127B, VAL2132B
• A-G: ALA1010A, ALA1031A, ALA1034A, ALA1090A, ALA1093A, ALA1094A, ALA1132A, ALA7112G, ALA7121G, ALA7145G, ALA7162G, ALA7163G, ALA7171G, ALA7173G, ARG1014A, ARG1091A, ARG1096A, ARG1131A, ARG1135A, ARG7019G, ARG7114G, ARG7168G, ASN1036A, ASN1092A, ASN1221A, ASN7011G, ASN7020G, ASN7126G, ASP1013A, ASP1061A, ASP1065A, ASP1089A, ASP7008G, ASP7017G, ASP7113G, ASP7180G, GLN1027A, GLN1037A, GLN7117G, GLN7120G, GLN7169G, GLU1029A, GLU7024G, GLU7151G, GLU7174G, GLU7176G, GLY1011A, GLY1085A, GLY1138A, GLY7004G, GLY7006G, GLY7018G, GLY7038G, GLY7116G, GLY7154G, GLY7158G, GLY7161G, HIS1015A, HIS7122G, HIS7146G, ILE1016A, ILE1040A, ILE1072A, ILE1087A, ILE7039G, LEU1063A, LEU1064A, LEU1095A, LEU1137A, LEU7009G, LEU7124G, LEU7147G, LEU7150G, LEU7175G, LEU7178G, LYS1033A, LYS1062A, LYS1098A, LYS7040G, LYS7160G, LYS7172G, LYS7177G, MET1134A, MET7149G, PHE1032A, PHE1073A, PHE7014G, PHE7137G, PRO1060A, PRO1066A, PRO1086A, PRO1088A, PRO1136A, PRO1159A, PRO7016G, PRO7109G, PRO7152G, SER1070A, SER7010G, SER7012G, SER7015G, SER7127G, SER7153G, SER7155G, THR1017A, THR1035A, THR1038A, THR1067A, THR1068A, THR7005G, THR7123G, TRP7157G, TYR1012A, TYR1026A, TYR1030A, TYR1071A, TYR1128A, TYR1133A, TYR7007G, TYR7125G, TYR7148G, TYR7156G, TYR7159G, VAL1028A, VAL1059A, VAL1069A, VAL1139A, VAL7013G, VAL7023G, VAL7119G, VAL7179G
• A-H: ALA1054H, ALA1056H, ALA1094A, ALA1097A, ALA1099A, ALA1101A, ALA1102A, ARG1036H, ARG1077A, ARG1096A, ARG1105A, ASP1039H, ASP1057H, ASP1111A, CYS1074A, GLN1053H, GLN1060H, GLN1069H, GLU1064H, GLU1100A, GLU1103A, GLY1071H, HIS1038H, HIS1062H, ILE1055H, ILE1058H, ILE1075A, LEU1063H, LEU1065H, LEU1095A, LYS1098A, LYS1107A, LYS1232A, MET1112A, PHE1073A, PHE1104A, SER1068H, SER1076A, THR1067H, THR1072H, THR1078A, TYR1061H, TYR1066H, TYR1070H, TYR1106A, VAL1037H, VAL1059H
• A-I: ALA1118A, ALA1122A, ALA2079I, ARG1105A, ARG1120A, ARG2072I, ARG2075I, ASN1123A, ASN2062I, ASP1111A, ASP1115A, ASP1147A, ASP2104I, CYS1114A, GLN2081I, GLN2085I, GLU1100A, GLU1148A, GLU1149A, GLU2073I, GLY1109A, GLY1151A, HIS2066I, ILE1079A, ILE1127A, ILE2059I, ILE2063I, LEU1117A, LEU1124A, LEU1150A, LEU2065I, LEU2068I, LEU2080I, LEU2083I, LYS1107A, LYS1119A, LYS2084I, MET1112A, MET1121A, MET2082I, PHE1104A, PHE2088I, PRO1113A, PRO2074I, PRO2105I, SER1145A, SER1153A, SER2067I, SER2071I, SER2078I, THR2070I, THR2106I, TYR1106A, TYR1108A, TYR1110A, TYR1155A, TYR1163A, TYR2069I, VAL1116A, VAL2076I, VAL2077I
• A-2: ARG1077A, ARG1105A, ASP1111A, ASP1231A, GLN72232, GLU1148A, GLY1109A, GLY72212, ILE72252, LYS72242, THR1078A, THR72222, TYR1106A, TYR1108A, TYR1110A
• A-4: ARG1014A, ARG1024A, ARG8674, ASP7674, ASP7694, ASP8094, GLU1029A, GLU1177A, GLU1183A, GLU8134, LYS1033A, LYS1174A, LYS8124, LYS8144, LYS8704
• B-C: ALA2115B, ALA2161B, ALA2163B, ALA2171B, ALA3082C, ARG2178B, ARG3050C, ARG3092C, ARG3129C, ASN2143B, ASN2180B, ASN3089C, ASP3060C, ASP3083C, ASP3209C, GLN2119B, GLN2123B, GLN2149B, GLN3059C, GLU2113B, GLU2120B, GLU2176B, GLU3058C, GLU3064C, GLU3085C, GLY2036B, GLY2125B, GLY2154B, GLY3127C, ILE2021B, ILE2037B, ILE2117B, ILE3086C, LEU2109B, LEU2147B, LEU2175B, LEU3056C, LEU3057C, LEU3080C, LEU3128C, LYS2038B, LYS2108B, LYS2116B, LYS2160B, LYS2172B, LYS2177B, LYS3051C, PHE2145B, PHE2157B, PHE2174B, PHE3131C, PRO2158B, PRO3130C, SER2112B, SER2124B, SER2146B, SER2153B, SER2155B, SER3054C, SER3062C, THR2122B, THR2162B, THR2173B, THR3053C, THR3055C, THR3061C, THR3063C, THR3081C, TRP2159B, TRP2179B, TYR2148B, TYR2156B, TYR3067C, TYR3122C, TYR3208C
• B-I: ALA2093B, ALA2184I, ARG2036I, ARG2083B, ARG2090B, ARG2099B, ARG2188I, ASN2062I, ASP2087B, ASP2183I, ASP2220B, ASP2230B, CYS2176I, GLN2057I, GLU2064I, GLU2073I, GLU2185I, GLY2060I, GLY2102B, GLY2223B, GLY2226B, HIS2035I, HIS2066I, HIS2094B, ILE2037I, ILE2041I, ILE2059I, ILE2063I, ILE2100B, ILE2227B, LEU2034I, LEU2058I, LEU2065I, LEU2066B, LEU2067B, LEU2068I, LEU2187I, LEU2221B, LEU2222B, LYS2040I, LYS2088B, LYS2091B, LYS2098B, LYS2182I, MET2082I, MET2178I, PRO2039I, PRO2069B, PRO2219B, PRO2228B, PRO2233B, SER2038I, SER2061I, SER2062B, SER2065B, SER2067I, SER2071I, SER2089B, THR2056I, THR2060B, THR2068B, THR2070I, THR2095B, THR2225B, TRP2042I, TYR2069I, TYR2101B, TYR2104B, TYR2186I, TYR2224B, VAL2084B, VAL2086B, VAL2092B, VAL2103I, VAL2175I, VAL2177I
• B-J: ALA3072J, ARG2099B, ARG3071J, ASN2143B, ASN3104J, ASP2140B, GLN3080J, GLU2103B, GLU2113B, GLU2141B, GLU3069J, GLU3070J, GLU3074J, GLU3076J, GLU3088J, GLY2102B, GLY2144B, HIS3039J, ILE2100B, ILE3073J, ILE3121J, LEU2109B, LEU3064J, LEU3067J, LEU3081J, LYS2098B, LYS2108B, LYS3061J, LYS3066J, LYS3068J, LYS3106J, LYS3109J, PHE2142B, PHE3058J, PHE3078J, PRO2105B, PRO2106B, PRO3075J, SER2096B, SER2112B, SER3083J, SER3084J, SER3085J, SER3105J, SER3107J, THR2229B, THR3062J, THR3077J, THR3079J, TYR2097B, TYR2101B, TYR2104B, TYR2148B, TYR2156B, TYR3065J, VAL3082J
• B-4: ARG10034, ARG8594, GLU10074, GLU2201B, GLU2203B, GLU8634, HIS10044, LYS2050B, LYS2197B
• B-5: GLU11955, LYS2177B
• C-D: ALA3040C, ALA3162C, ALA3172C, ALA4023D, ALA4026D, ALA4080D, ARG3018C, ARG3113C, ARG3114C, ARG3143C, ARG4029D, ARG4048D, ARG4058D, ARG4083D, ARG4090D, ARG4127D, ASN3152C, ASN3156C, ASN4079D, ASP3117C, ASP3179C, ASP3182C, ASP4056D, ASP4081D, GLN3120C, GLN3124C, GLN3147C, GLN3173C, GLN3177C, GLN4019D, GLN4055D, GLN4117D, GLU3016C, GLU3023C, GLU3109C, GLU4021D, GLU4025D, GLU4087D, GLY3017C, GLY3037C, GLY3121C, GLY3126C, GLY3127C, GLY3145C, GLY3155C, GLY3159C, GLY4077D, GLY4124D, GLY4125D, GLY4130D, HIS3125C, ILE3038C, ILE3044C, ILE3118C, ILE3163C, ILE4059D, ILE4084D, ILE4086D, LEU3019C, LEU3115C, LEU3128C, LEU3148C, LEU3175C, LEU3176C, LEU3192C, LEU4024D, LEU4052D, LEU4054D, LEU4078D, LEU4085D, LYS3119C, LYS3161C, LYS3181C, LYS4028D, LYS4053D, LYS4088D, MET3039C, MET3178C, PHE4075D, PHE4129D, PRO3015C, PRO3153C, PRO4061D, PRO4128D, SER3014C, SER3041C, SER3116C, SER3151C, SER3154C, SER3164C, SER4062D, SER4082D, THR3123C, THR3150C, THR3158C, THR3174C, THR4051D, THR4057D, THR4060D, TRP3160C, TYR3020C, TYR3122C, TYR3144C, TYR3146C, TYR3149C, TYR3157C, TYR3180C, TYR4022D, TYR4120D, VAL3022C, VAL3108C, VAL3112C, VAL4027D, VAL4116D, VAL4126D, VAL4131D
• C-I: ALA3220C, ASN2219I, ASP2222I, ASP3071C, CYS2221I, GLN3227C, GLU3224C, LYS3068C, LYS3072C, TYR3226C, VAL3225C
• C-J: ALA3091C, ALA3095C, ARG3059J, ARG3092C, ASN3055J, ASN3063J, ASN3070C, ASN3089C, ASN3097C, ASN3103C, ASP3071C, ASP3105C, GLN3096C, GLN3227C, GLU3056J, GLU3069J, GLU3070J, GLU3104C, HIS3094C, ILE3073C, ILE3088C, ILE3093C, ILE3229C, LEU3054J, LEU3064J, LEU3067J, LEU3069C, LEU3099C, LYS3061J, LYS3066J, LYS3068C, LYS3068J, LYS3072C, LYS3100C, MET3057J, PHE3058J, SER3062C, THR3052J, THR3053J, THR3061C, THR3062J, THR3063C, THR3090C, THR3101C, TYR3060J, TYR3065J, TYR3067C, TYR3094J, TYR3098C, TYR3102C
• C-K: ALA4078K, ALA4088K, ARG3113C, ARG3143C, ARG4069K, ARG4084K, ASN3097C, ASN3103C, ASN4062K, ASP3105C, ASP3117C, ASP3141C, ASP3142C, ASP4071K, ASP4107K, GLN4077K, GLN4085K, GLU3104C, GLU3109C, GLU4070K, GLU4073K, GLU4086K, GLY3145C, HIS3094C, ILE3106C, ILE3110C, ILE4063K, LEU3099C, LEU4074K, LYS3100C, LYS4089K, LYS4109K, LYS4110K, LYS4124K, PHE4082K, PRO3107C, PRO4076K, SER4067K, SER4075K, SER4080K, SER4081K, THR3101C, TYR3098C, TYR3102C, TYR3140C, TYR3144C, TYR4066K, TYR4072K, VAL4079K, VAL4083K
• C-5: ASP13835, ASP3179C, ASP3202C, ASP3209C, GLU13755, GLU14975, HIS14955, LYS14945, LYS3199C
• D-E: ALA4114D, ALA4161D, ALA5083E, ALA5085E, ARG4111D, ARG4119D, ARG4172D, ARG4181D, ARG5086E, ARG5093E, ARG5136E, ASN4178D, ASN5215E, ASP4180D, ASP5062E, ASP5084E, GLN4118D, GLN4122D, GLN4149D, GLN4162D, GLN5023E, GLU4107D, GLU4151D, GLU4173D, GLU4176D, GLU5060E, GLU5065E, GLU5090E, GLU5125E, GLY4035D, GLY4115D, GLY4124D, GLY4125D, GLY4154D, GLY5080E, GLY5139E, ILE4017D, ILE4155D, ILE5064E, LEU4147D, LEU4175D, LEU5058E, LEU5059E, LEU5081E, LEU5133E, LYS4037D, LYS4146D, LYS4177D, MET5088E, MET5134E, PHE4174D, PHE5138E, PRO4145D, PRO5057E, PRO5137E, SER4123D, SER4153D, SER4157D, SER4158D, SER4160D, SER5056E, SER5061E, SER5063E, SER5087E, SER5135E, THR4110D, THR4121D, THR4163D, THR5055E, THR5082E, TRP4159D, TYR4148D, TYR4156D, TYR4179D, VAL4020D, VAL4036D, VAL4126D, VAL4171D, VAL5012E, VAL5068E
• D-K: ALA4056K, ALA4061K, ALA4089D, ALA4093D, ARG4035K, ARG4069K, ARG4090D, ARG4097D, ASN4062K, ASP4068D, ASP4071K, GLN4054K, GLN4060K, GLN4064K, GLN4094D, GLU4057K, GLU4070K, GLU4087D, GLU4092D, GLU4101D, HIS4070D, HIS4096D, ILE4059K, ILE4063K, ILE4067D, ILE4068K, ILE4086D, ILE4221D, LEU4065K, LEU4098D, LYS4066D, LYS4088D, PHE4055K, SER4062D, SER4065D, SER4067K, SER4069D, SER4095D, THR4099D, TYR4058K, TYR4066K, TYR4097K, VAL4053K, VAL4071D, VAL4091D
• D-L: ALA5077L, ALA5078L, ALA5079L, ARG4097D, ARG4111D, ARG4141D, ARG5069L, ARG5106L, ARG5121L, ASN5085L, ASP4102D, ASP4139D, ASP4142D, CYS5063L, GLN5062L, GLU4101D, GLU4107D, GLU5070L, GLU5072L, GLU5108L, GLY5109L, HIS4096D, HIS5066L, ILE5074L, ILE5082L, LEU4098D, LEU4100D, LEU4109D, LEU5068L, LEU5083L, LYS5071L, LYS5081L, LYS5107L, LYS5123L, PRO4140D, SER5075L, SER5080L, THR4099D, THR4105D, THR5105L, THR5111L, TYR4108D, TYR4148D, TYR4156D, TYR5113L, VAL4104D, VAL5076L
• D-5: ARG4049D, ARG4166D, ASP16665, ASP16675, ASP17155, ASP17955, GLN17605, GLN4204D, GLU16235, GLU17115, GLU17185, GLU17535, GLU4173D, GLU4176D, GLU4201D, GLU4237D, HIS17145, HIS17595, LYS16685, LYS18735, LYS4053D, LYS4169D, LYS4177D, LYS4208D, LYS4240D
• E-F: ALA5041E, ALA5127E, ALA5169E, ALA5171E, ALA5179E, ALA5181E, ALA6025F, ALA6028F, ALA6053F, ALA6078F, ALA6081F, ARG5005E, ARG5020E, ARG5122E, ARG5132E, ARG5166E, ARG6003F, ARG6051F, ARG6082F, ARG6089F, ARG6126F, ASN5168E, ASN5185E, ASN6004F, ASN6005F, ASN6052F, ASN6086F, ASN6119F, ASP5118E, ASP6007F, ASP6009F, ASP6054F, ASP6080F, CYS5117E, GLN5114E, GLN5180E, GLN6021F, GLN6031F, GLN6060F, GLN6090F, GLN6121F, GLU5007E, GLU5018E, GLU5025E, GLU5110E, GLU5125E, GLU5130E, GLU5182E, GLU5186E, GLU6023F, GLU6027F, GLU6055F, GLY5011E, GLY5019E, GLY5039E, GLY5124E, GLY5126E, GLY5129E, GLY5162E, GLY6008F, GLY6124F, GLY6125F, GLY6129F, HIS5157E, HIS5188E, ILE5040E, ILE6029F, ILE6064F, LEU5021E, LEU5119E, LEU5121E, LEU5155E, LEU5183E, LEU5184E, LEU5191E, LEU5199E, LEU6026F, LEU6056F, LEU6074F, LEU6077F, LYS5170E, LYS6030F, LYS6050F, LYS6061F, LYS6115F, LYS6118F, MET6001F, PHE5015E, PHE5123E, PHE5156E, PHE5164E, PHE6002F, PHE6020F, PRO5017E, PRO6079F, PRO6127F, PRO6149F, SER5006E, SER5013E, SER5016E, SER5111E, SER5115E, SER5128E, SER5161E, SER6057F, SER6058F, SER6122F, THR5014E, THR5163E, THR6010F, THR6120F, TRP5187E, TYR5008E, TYR5165E, TYR5167E, TYR6024F, TYR6059F, TYR6087F, TYR6123F, TYR6128F, VAL5012E, VAL5024E, VAL6022F, VAL6083F, VAL6130F
• E-L: ALA5092E, ALA5095E, ALA5096E, ARG5064L, ARG5069L, ARG5072E, ARG5086E, ARG5093E, ASN5100E, ASP5062E, ASP5071E, ASP5104E, ASP5106E, CYS5063L, GLN5053L, GLN5062L, GLU5056L, GLU5065E, GLU5067L, GLU5069E, GLU5070L, GLU5090E, GLY5060L, GLY5227E, HIS5066L, HIS5073E, HIS5091E, HIS5099E, ILE5067E, ILE5070E, ILE5074E, ILE5089E, ILE5230E, LEU5059L, LEU5065L, LEU5068L, LEU5101E, LYS5071L, PHE5054L, PHE5228E, PRO5039L, SER5061L, SER5063E, THR5057L, THR5094E, THR5098E, TRP5055L, TRP5058L, TYR5102E, VAL5068E, VAL5097E
• E-M: ALA5096E, ALA5149E, ALA6080M, ALA6081M, ARG6082M, ASN5100E, ASN5108E, ASN6071M, ASN6078M, ASN6083M, ASP5104E, ASP5106E, ASP5148E, ASP5150E, ASP5151E, ASP6069M, GLN5114E, GLN6085M, GLU5105E, GLU5110E, GLU6107M, GLY6090M, HIS5099E, HIS6070M, HIS6086M, ILE5107E, ILE6077M, ILE6084M, LEU5101E, LEU5112E, LEU6075M, LEU6087M, LYS6073M, LYS6074M, PHE6059M, SER5111E, SER5115E, SER6062M, SER6076M, SER6079M, THR5098E, TRP6065M, TYR5102E, TYR5103E, TYR6066M, TYR6089M, TYR6114M, TYR6122M, VAL5097E, VAL5109E, VAL6063M
• E-4: ARG5005E, GLU5007E, HIS5234, LYS5894
• E-5: ARG21395, ARG5005E, ARG5020E, ARG5053E, ASP19195, ASP21165, ASP5009E, ASP5213E, GLU20055, GLU5007E, GLU5018E, GLU5025E, GLU5051E, GLU5159E, GLU5177E, GLU5209E, GLU5210E, HIS19175, LYS19185, LYS21115, LYS21125, LYS5211E, SER21085, SER5006E, TYR20745
• F-G: ALA6116F, ALA6142F, ALA6160F, ALA6168F, ALA7026G, ALA7029G, ARG6018F, ARG6039F, ARG6107F, ARG6174F, ARG7085G, ARG7092G, ARG7129G, ASN6005F, ASN6119F, ASN6152F, ASN7011G, ASN7032G, ASN7063G, ASN7089G, ASN7126G, ASP6007F, ASP6009F, ASP6114F, ASP6138F, ASP6177F, ASP7008G, ASP7083G, CYS6113F, GLN6117F, GLN6121F, GLN6148F, GLN7022G, GLN7067G, GLU6106F, GLU6146F, GLU6155F, GLU6173F, GLU7024G, GLU7031G, GLU7093G, GLY6008F, GLY6017F, GLY6037F, GLY6109F, GLY6124F, GLY6141F, GLY6151F, GLY6158F, GLY7006G, GLY7079G, GLY7084G, GLY7132G, HIS6110F, HIS6143F, HIS7086G, HIS7122G, ILE6180F, ILE7053G, ILE7081G, LEU6019F, LEU6038F, LEU6111F, LEU6112F, LEU6144F, LEU6145F, LEU6156F, LEU6172F, LEU6176F, LEU7009G, LEU7052G, LEU7057G, LEU7058G, LEU7080G, LEU7087G, LYS6115F, LYS6118F, LYS6169F, LYS7028G, LYS7051G, LYS7056G, LYS7062G, LYS7065G, LYS7209G, PHE6013F, PHE6179F, PHE7021G, PHE7131G, PRO6015F, PRO6149F, PRO7060G, PRO7082G, PRO7130G, PRO7152G, SER6014F, SER6122F, SER6140F, SER6150F, SER7010G, SER7012G, SER7055G, SER7127G, THR6010F, THR6012F, THR6016F, THR6120F, THR6154F, THR6159F, THR6170F, THR6175F, THR7054G, TYR6006F, TYR6123F, TYR6157F, TYR6171F, TYR7007G, TYR7025G, TYR7118G, TYR7125G, VAL6011F, VAL6022F, VAL6105F, VAL6153F, VAL7023G, VAL7027G, VAL7030G, VAL7059G, VAL7064G, VAL7088G, VAL7128G, VAL7133G
• F-M: ARG6058M, ARG6082F, ARG6089F, ASN6061M, ASN6071M, ASN6086F, ASN6093F, ASN6100F, ASP6067F, ASP6069M, ASP6072M, CYS6066F, CYS6092F, GLN6090F, GLN6091F, GLU6068F, HIS6067M, HIS6069F, HIS6070M, ILE6064F, ILE6224F, LEU6088F, LEU6097F, LEU6103F, LYS6057M, LYS6060M, LYS6061F, LYS6064M, LYS6065F, LYS6102F, MET6070F, PHE6068M, PHE6099F, SER6062M, SER6085F, SER6096F, THR6223F, TRP6065M, TYR6087F, TYR6094F, VAL6098F
• F-N: ALA6104F, ALA7067N, ALA7073N, ALA7075N, ALA7078N, ALA7089N, ARG6101F, ARG6107F, ASN6100F, ASN7066N, ASN7070N, ASN7114N, ASP6114F, ASP6138F, ASP7069N, GLN7094N, GLN7112N, GLU6106F, GLU7065N, GLU7076N, GLU7077N, GLU7080N, GLU7086N, GLY6141F, HIS6069F, HIS6110F, HIS6143F, ILE7084N, LEU6097F, LEU6103F, LEU7058N, LEU7059N, LEU7062N, LEU7072N, LEU7079N, LEU7088N, LYS6102F, LYS6139F, PHE6099F, PHE7085N, PHE7118N, PRO7071N, PRO7081N, SER6095F, SER6096F, SER6140F, SER7082N, SER7113N, THR7090N, TYR6094F, TYR7068N, TYR7083N, TYR7087N, VAL6098F, VAL6105F, VAL7091N
• F-4: ARG6003F, ARG6354, ARG6374, ASN6005F, ASN6334, GLN5874, HIS6364, LYS5894, MET6001F, SER6014F
• F-5: ALA21435, ALA6078F, ARG20485, ARG20945, ARG6003F, ARG6164F, ARG6202F, ASP21165, ASP21325, ASP6203F, GLN20495, GLN6031F, GLU20475, GLU21315, GLU21345, GLU6027F, GLU6055F, GLU6204F, GLY6076F, LYS20535, LYS21115, LYS6030F, LYS6062F, PHE6002F, SER20455, TYR21415
• G-H: ALA1078H, ALA1079H, ALA7110G, ARG7114G, ASN1106H, ASN7143G, ASP1103H, ASP7113G, GLN1069H, GLN7117G, GLU1076H, GLU1084H, GLU1088H, GLU7094G, GLY1071H, HIS1062H, ILE1058H, ILE7106G, LEU1063H, LEU1065H, LEU1085H, LEU7101G, LYS1083H, LYS1105H, LYS7099G, LYS7100G, LYS7103G, LYS7142G, PHE1082H, PHE7098G, PHE7111G, PRO1073H, PRO7105G, PRO7107G, PRO7109G, SER1074H, SER1080H, SER7097G, THR1072H, THR1075H, THR1077H, THR7104G, TYR1061H, TYR1066H, TYR1070H, TYR1087H, TYR1111H, TYR7102G, VAL1059H, VAL1081H, VAL1119H
• G-N: ALA7067N, ALA7073N, ALA7075N, ALA7095G, ALA7096G, ARG7057N, ARG7071G, ARG7085G, ARG7092G, ASN7063G, ASN7066N, ASN7070N, ASN7089G, ASP7061N, ASP7069N, ASP7070G, ASP7074N, GLN7053N, GLN7061G, GLN7067G, GLU7056N, GLU7065N, GLU7093G, GLY7038N, GLY7091G, HIS7054N, HIS7072G, HIS7227G, ILE7066G, ILE7073G, LEU7058N, LEU7059N, LEU7062N, LEU7072N, LEU7079N, LEU7101G, LYS7060N, LYS7062G, LYS7065G, LYS7099G, LYS7100G, LYS7103G, LYS7228G, LYS7231G, PHE7229G, PRO7071N, PRO7105G, THR7064N, TYR7068N, TYR7077G, VAL7037N, VAL7063N, VAL7064G, VAL7068G, VAL7069G, VAL7088G
• G-4: ASN6764, ASP6774, ASP7008G, ASP7017G, ASP7674, GLU8134, SER7015G
• H-I: ALA1024H, ALA1027H, ALA1049H, ALA1050H, ALA1054H, ALA1056H, ALA2115I, ALA2133I, ALA2134I, ALA2136I, ARG1029H, ARG1045H, ARG1174H, ASN1028H, ASN1089H, ASN1092H, ASP1032H, ASP1051H, ASP1057H, ASP2120I, GLN1053H, GLN1060H, GLN2081I, GLN2085I, GLN2091I, GLU2139I, GLY2092I, GLY2117I, GLY2122I, GLY2130I, HIS2114I, HIS2116I, ILE1026H, ILE1055H, ILE1058H, ILE2113I, LEU1093H, LEU2080I, LEU2087I, LEU2125I, LEU2127I, LEU2132I, LEU2138I, LYS2084I, MET2135I, PHE2088I, SER1048H, SER2112I, SER2118I, SER2126I, SER2131I, SER2140I, THR1020H, THR1022H, THR1031H, THR1052H, THR1094H, THR2119I, TRP2142I, TYR1025H, TYR1061H, TYR2097I, TYR2123I, TYR2124I, VAL1030H, VAL2121I
• H-N: ALA1125H, ALA1127H, ARG7027N, ARG7057N, ARG7095N, ASN7029N, ASN7100N, ASP1091H, ASP1139H, ASP7048N, ASP7051N, CYS1086H, GLN702N, GLN703N, GLN7053N, GLU1084H, GLU1088H, GLU7056N, GLY1096H, GLY1116H, GLY1117H, GLY1128H, GLY7020N, GLY7030N, HIS1120H, HIS7054N, ILE1003H, ILE1097H, ILE1098H, ILE1113H, ILE1126H, ILE7049N, ILE7055N, ILE705N, LEU1115H, LEU1122H, LEU7025N, LEU7026N, LEU7058N, LEU7102N, LYS1083H, LYS1090H, LYS1121H, MET7052N, MET7099N, PHE7028N, PRO1114H, PRO704N, PRO7101N, SER1046H, SER1080H, SER1118H, SER1129H, SER1131H, SER7050N, THR1094H, THR1112H, THR1132H, THR701N, THR707N, TRP7103N, TYR1087H, TYR1124H, TYR1135H, TYR7022N, VAL1119H, VAL7031N, VAL706N
• H-V: ALA1162H, ALA1162V, ASN1141H, ASN1141V, ASP1139H, ASP1139V, ASP1153H, ASP1153V, CYS1138H, CYS1138V, GLN1161H, GLN1161V, GLN1195H, GLN1195V, GLU1194H, GLU1194V, GLY1136H, GLY1136V, HIS1157H, HIS1157V, ILE1126H, ILE1126V, ILE1134H, ILE1134V, LEU1159V, LEU1196H, LEU1196V, LYS1140H, LYS1140V, LYS1156H, LYS1156V, LYS1164H, LYS1164V, PHE1133H, PHE1133V, PHE1154H, PHE1154V, SER1131H, SER1131V, SER1158H, SER1158V, SER1160H, SER1160V, THR1132H, THR1132V, TRP1165H, TRP1165V, TYR1124H, TYR1124V, TYR1135H, TYR1135V, TYR1137H, TYR1137V, TYR1193H, TYR1193V
• H-2: ALA1024H, ALA1027H, ALA1049H, ALA1054H, ALA1056H, ALA1162H, ALA71812, ALA72142, ARG1019H, ARG1029H, ARG1036H, ARG1045H, ARG1174H, ARG1185H, ARG70272, ARG71742, ARG71792, ARG71822, ARG71852, ASN1028H, ASN70292, ASN72082, ASP1032H, ASP1039H, ASP1057H, ASP1166H, ASP1191H, ASP71802, ASP72122, ASP72162, CYS1043H, GLN1053H, GLN1060H, GLN1161H, GLN1195H, GLN72052, GLN72232, GLU1184H, GLU1192H, GLU1194H, GLU72072, GLY1023H, GLY1130H, GLY1167H, GLY1170H, GLY1171H, GLY70232, GLY72192, GLY72212, HIS1038H, HIS71412, ILE1026H, ILE1055H, ILE1058H, ILE1163H, ILE1173H, ILE1187H, ILE72172, ILE72252, LEU1034H, LEU1178H, LEU1186H, LEU70192, LEU70252, LEU70262, LEU71762, LYS1033H, LYS1164H, LYS72102, LYS72152, LYS72182, LYS72242, MET71422, MET72092, PHE1133H, PHE1188H, PHE70282, PHE71382, PHE72132, PRO1190H, SER1018H, SER1129H, SER1168H, SER1169H, SER70212, SER70242, SER71832, SER71842, THR1020H, THR1021H, THR1022H, THR1031H, THR1035H, THR1052H, THR1132H, THR70012, THR72222, TRP1042H, TRP1165H, TRP72112, TYR1025H, TYR1189H, TYR1193H, TYR70222, TYR71772, TYR71782, TYR72202, VAL1030H, VAL1037H, VAL1059H, VAL1172H, VAL1176H, VAL1183H, VAL71752, VAL72062
• I-J: ALA2027I, ALA2032I, ALA2049I, ALA2050I, ALA2054I, ALA2096I, ALA2211I, ALA3072J, ALA3124J, ALA3161J, ALA3176J, ARG2188I, ARG2196I, ARG2207I, ARG3090J, ARG3189J, ASN2030I, ASN2189I, ASN2219I, ASN3148J, ASN3164J, ASP2028I, ASP2051I, ASP2222I, ASP3116J, ASP3122J, ASP3126J, ASP3135J, ASP3153J, ASP3184J, CYS2031I, CYS2221I, CYS3120J, CYS3141J, GLN2022I, GLN2057I, GLN3080J, GLN3136J, GLN3160J, GLN3195J, GLU2053I, GLU2215I, GLU3032J, GLU3123J, GLU3142J, GLU3146J, GLU3150J, GLU3152J, GLU3156J, GLU3185J, GLY2092I, GLY2095I, GLY2208I, GLY3038J, GLY3114J, GLY3119J, GLY3131J, GLY3139J, GLY3175J, HIS2035I, HIS2086I, HIS2093I, HIS3036J, HIS3039J, ILE2025I, ILE2094I, ILE2217I, ILE2220I, ILE3103J, ILE3118J, ILE3121J, ILE3128J, ILE3158J, ILE3180J, ILE3181J, LEU2058I, LEU2213I, LEU3018J, LEU3117J, LEU3144J, LEU3149J, LEU3154J, LEU3162J, LEU3163J, LEU3191J, LYS2029I, LYS2199I, LYS2201I, LYS2204I, LYS2214I, LYS3030J, LYS3066J, LYS3125J, LYS3182J, LYS3183J, LYS3188J, LYS3192J, MET3006J, MET3140J, MET3193J, PHE2205I, PHE3041J, PHE3091J, PHE3115J, PHE3127J, PHE3138J, PHE3155J, PRO2024I, PRO2206I, PRO3147J, PRO3151J, SER2020I, SER2202I, SER2216I, SER3083J, SER3084J, SER3130J, SER3134J, SER3143J, SER3159J, THR2048I, THR2052I, THR2209I, THR2210I, THR3157J, TRP3174J, TYR2090I, TYR2203I, TYR3037J, TYR3087J, TYR3145J, TYR3179J, TYR3190J, VAL2026I, VAL2055I, VAL2195I, VAL2212I, VAL2218I, VAL3040J, VAL3129J, VAL3177J, VAL3178J, VAL3186J, VAL3187J
• I-Z: GLY5212Z, ILE5211Z, LEU2213I, LYS2214I, LYS5201Z, TRP5198Z, VAL5210Z
• I-1: ALA2027I, ALA2133I, ALA2161I, ALA2211I, ALA61321, ALA61331, ALA61821, ARG2019I, ARG2196I, ARG2207I, ARG60191, ARG60291, ARG61761, ARG61851, ARG62121, ASN2030I, ASN2165I, ASN2172I, ASN2194I, ASN60201, ASN60271, ASN6081, ASN61431, ASN61491, ASN61561, ASP2017I, ASP2028I, ASP2166I, ASP60231, ASP61771, ASP61911, ASP62131, GLN2022I, GLN2160I, GLN2200I, GLN61441, GLN61501, GLN61881, GLU2197I, GLU2198I, GLU61521, GLU61691, GLU61701, GLU61841, GLU62091, GLY2023I, GLY2130I, GLY2162I, GLY2168I, GLY2170I, GLY2208I, GLY6091, GLY61541, GLY61571, GLY61901, HIS61861, ILE2025I, ILE2163I, ILE60211, ILE60261, ILE61721, ILE61871, LEU2132I, LEU2167I, LEU2213I, LEU61361, LEU61411, LEU61661, LEU61741, LEU62101, LYS2029I, LYS2199I, LYS2201I, LYS2204I, LYS61481, LYS61581, LYS61601, LYS61611, LYS61731, LYS62111, PHE2205I, PHE61401, PHE61471, PHE61791, PRO2024I, PRO2193I, PRO2206I, PRO61531, SER2020I, SER2129I, SER2169I, SER2171I, SER2202I, SER60251, SER61351, SER61781, SER61811, THR2001I, THR2021I, THR2209I, THR2210I, THR60221, THR61551, THR61801, THR61831, TRP2164I, TYR2203I, TYR60241, TYR61511, TYR62081, VAL2026I, VAL2195I, VAL2212I, VAL61451, VAL61591, VAL61711, VAL61751, VAL61891
• I-2: ALA2133I, ALA2134I, ALA2136I, ALA2158I, ALA2161I, ALA71402, ALA71432, ALA71722, ALA72142, ARG2075I, ARG71482, ARG71742, ARG71792, ASN2165I, ASN71442, ASN71712, ASP2120I, ASP2145I, ASP2157I, ASP2166I, ASP71522, ASP71802, ASP72122, ASP72162, GLN2081I, GLN2085I, GLN2144I, GLN2160I, GLN72232, GLU2139I, GLY2117I, GLY2122I, GLY2130I, GLY2162I, GLY71392, GLY72192, GLY72212, HIS2109I, HIS2141I, HIS71412, ILE2113I, ILE72172, LEU2080I, LEU2110I, LEU2125I, LEU2132I, LEU2138I, LEU2154I, LEU2167I, LEU71462, LEU71472, LEU71762, LYS2007I, LYS2084I, LYS2143I, LYS2153I, LYS71492, LYS72102, LYS72152, LYS72182, LYS72242, MET2135I, MET71422, PHE2111I, PHE71382, PHE72132, PRO71452, SER2078I, SER2112I, SER2118I, SER2126I, SER2129I, SER2131I, SER2140I, THR2106I, THR2119I, THR71332, THR72222, TRP2142I, TRP2164I, TRP72112, TYR2123I, TYR2124I, TYR71782, TYR72202, VAL2076I, VAL2077I, VAL2121I, VAL2137I, VAL71752
• J-K: ALA3048J, ALA4088K, ALA4131K, ARG3059J, ARG3089J, ARG4007K, ARG4084K, ARG4092K, ASN3029J, ASN3055J, ASN307J, ASP3050J, ASP4119K, ASP4144K, GLN3023J, GLN4077K, GLN4085K, GLN4117K, GLU3032J, GLU3056J, GLU4126K, GLY3021J, GLY3026J, GLY3092J, GLY4122K, GLY4130K, GLY4133K, GLY4136K, HIS4132K, ILE306J, ILE4091K, ILE4118K, LEU3018J, LEU3020J, LEU3025J, LEU3047J, LEU3054J, LEU3117J, LEU4087K, LEU4102K, LEU4121K, LEU4127K, LYS3030J, LYS4089K, LYS4124K, MET3057J, PHE3031J, PHE3091J, PHE3095J, PHE4082K, PHE4137K, PHE4140K, PRO303J, PRO3093J, PRO4128K, SER3022J, SER3024J, SER3028J, SER4081K, SER4135K, THR3049J, THR3052J, THR3053J, THR4123K, THR4139K, TRP3174J, TYR3094J, TYR4120K, TYR4129K, TYR4134K, TYR4138K, VAL3027J, VAL3051J, VAL3096J, VAL4125K
• J-Z: ALA3133J, ALA3165J, ALA3166J, ALA3170J, ALA3176J, ALA5020Z, ALA5022Z, ALA5027Z, ALA5163Z, ALA5164Z, ALA5165Z, ALA5169Z, ARG3019J, ARG3168J, ARG3194J, ARG5019Z, ARG5167Z, ASN3029J, ASN3164J, ASN5024Z, ASN5208Z, ASN5209Z, ASP302J, ASP3135J, ASP3167J, ASP3169J, ASP3196J, ASP5017Z, ASP5168Z, ASP5192Z, GLN3023J, GLN3136J, GLN3195J, GLN5029Z, GLU5195Z, GLY3021J, GLY3026J, GLY308J, GLY3131J, GLY3173J, GLY3175J, GLY5023Z, GLY5132Z, GLY5172Z, GLY5173Z, GLY5194Z, GLY5212Z, HIS5166Z, HIS5191Z, ILE306J, ILE5211Z, LEU3018J, LEU3020J, LEU3025J, LEU3171J, LEU3191J, LEU5162Z, LEU5196Z, LYS3030J, LYS3192J, LYS5201Z, MET3193J, PHE5135Z, PHE5197Z, PHE5207Z, SER3024J, SER3028J, SER304J, SER305J, SER3134J, SER3172J, SER5018Z, SER5028Z, SER5131Z, SER5171Z, SER5174Z, THR3132J, THR5021Z, THR5030Z, THR5134Z, TRP3174J, TRP5025Z, TRP5198Z, TYR3190J, TYR5170Z, VAL3027J, VAL5026Z, VAL5193Z, VAL5210Z
• J-1: ALA3124J, ALA3133J, ALA3161J, ALA3165J, ALA3166J, ALA61291, ALA61321, ALA61331, ALA61341, ALA61821, ARG3168J, ARG3194J, ARG61281, ARG61851, ASN3164J, ASN61431, ASN61461, ASN61491, ASN61561, ASP3122J, ASP3126J, ASP3135J, ASP3167J, ASP3169J, ASP61421, ASP61771, CYS3141J, CYS61271, GLN3136J, GLN3160J, GLN61261, GLN61441, GLN61501, GLU3142J, GLU3156J, GLU61251, GLU61841, GLY3139J, GLY61571, HIS61861, ILE3128J, ILE61371, LEU3137J, LEU3144J, LEU3162J, LEU3163J, LEU3191J, LEU61361, LEU61411, LEU61741, LYS3125J, LYS3192J, LYS61481, LYS61581, LYS61601, MET3140J, MET3193J, MET61381, PHE3127J, PHE3138J, PHE61401, PHE61471, PHE61791, PRO61391, PRO61531, SER3134J, SER3143J, SER3159J, SER61351, SER61781, SER61811, THR61801, THR61831, TYR3145J, TYR61511, VAL3129J, VAL61591
• K-L: ALA4019K, ALA4049K, ALA5093L, ARG4022K, ARG4035K, ARG4094K, ARG4095K, ARG5121L, ASN5085L, ASP4029K, ASP4031K, ASP4032K, ASP4051K, ASP5116L, ASP5118L, ASP5125L, ASP5141L, CYS5128L, GLN4054K, GLN4098K, GLN5089L, GLN5133L, GLU4048K, GLU4057K, GLY4023K, GLY4050K, GLY5092L, GLY5119L, GLY5124L, GLY5130L, GLY5132L, ILE4024K, ILE5126L, LEU4027K, LEU5122L, LYS4028K, LYS4033K, LYS5081L, LYS5091L, LYS5123L, MET5100L, PHE4055K, PHE5127L, PHE5135L, PRO4096K, SER4025K, SER4030K, SER5084L, SER5117L, SER5131L, THR4021K, THR4052K, THR5120L, THR5134L, TYR4058K, TYR4097K, TYR5088L, TYR5090L, TYR5114L, TYR5137L, VAL4020K, VAL4026K, VAL4053K, VAL4099K, VAL5087L, VAL5129L
• K-Y: ALA4019K, ALA4019Y, ARG4022K, ARG4022Y, ARG4170K, ARG4170Y, ASP4029K, ASP4029Y, ASP4174K, ASP4174Y, GLN4165K, GLN4165Y, GLU4166K, GLU4166Y, GLU4168K, GLU4168Y, GLY4023K, GLY4023Y, ILE4024K, ILE4024Y, LEU4027K, LEU4027Y, LEU4167K, LEU4167Y, LYS4028K, LYS4028Y, LYS4169K, LYS4169Y, LYS4176K, LYS4176Y, MET4171K, MET4171Y, MET4173K, MET4173Y, PHE4137K, PHE4137Y, PHE4175K, PHE4175Y, PRO4172K, PRO4172Y, SER4025K, SER4025Y, SER4135K, SER4135Y, THR4021K, THR4021Y, TYR4134K, TYR4134Y, TYR4138K, TYR4138Y, VAL4020K, VAL4020Y, VAL4026K, VAL4026Y
• K-Z: ALA4131K, ALA5136Z, ALA5163Z, ALA5164Z, ALA5169Z, ARG4007K, ARG4148K, ARG4170K, ARG5159Z, ARG5167Z, ASN5143Z, ASN5208Z, ASN5209Z, ASP4144K, ASP4150K, ASP5125Z, ASP5141Z, ASP5168Z, CYS4163K, CYS5128Z, GLN4117K, GLN4165K, GLN5133Z, GLU4126K, GLU4166K, GLU5203Z, GLU5204Z, GLY4130K, GLY4136K, GLY5132Z, GLY5138Z, GLY5205Z, HIS4145K, HIS4146K, HIS5166Z, ILE5126Z, ILE5211Z, LEU4127K, LEU4142K, LEU4143K, LEU4162K, LEU4167K, LEU5140Z, LEU5156Z, LEU5162Z, LYS4169K, LYS5201Z, MET4171K, PHE4137K, PHE4140K, PHE5006Z, PHE5127Z, PHE5135Z, PHE5197Z, PHE5207Z, PRO4128K, PRO4149K, PRO4172K, SER4135K, SER4141K, SER5131Z, SER5142Z, SER5160Z, SER5206Z, THR4139K, THR5134Z, TYR4129K, TYR4134K, TYR4138K, TYR4147K, TYR5137Z, TYR5144Z, TYR5155Z, TYR5170Z, VAL4125K, VAL5139Z, VAL5200Z, VAL5210Z
• L-M: ALA5020L, ALA5022L, ALA5027L, ALA5049L, ALA5050L, ALA5093L, ALA6129M, ALA6133M, ALA6134M, ARG5033L, ARG6082M, ARG6092M, ARG6124M, ARG6128M, ASN6146M, ASN6149M, ASP5051L, ASP5192L, ASP6117M, ASP6142M, CYS5052L, CYS6127M, GLN5029L, GLN5053L, GLN6085M, GLN6126M, GLU5036L, GLU5195L, GLU5202L, GLU6123M, GLU6125M, GLY5048L, GLY5060L, GLY5092L, GLY5094L, GLY5173L, GLY5194L, GLY5212L, GLY6090M, GLY6120M, GLY6130M, GLY6131M, HIS6086M, HIS6099M, ILE5035L, ILE5037L, ILE6084M, ILE6137M, LEU5086L, LEU5095L, LEU6087M, LEU6088M, LEU6136M, LYS5032L, LYS6148M, LYS6158M, LYS6160M, MET5045L, MET6138M, PHE5054L, PHE6093M, PHE6116M, PHE6140M, PRO6118M, PRO6139M, SER5018L, SER5028L, SER5061L, SER5096L, SER6115M, SER6121M, SER6135M, THR5021L, THR5030L, THR5057L, TRP5025L, TRP5055L, TRP5058L, TRP5198L, TYR5090L, TYR6089M, TYR6122M, TYR6151M, VAL5026L, VAL5031L, VAL5034L, VAL5087L, VAL6119M
• L-W: GLY5212L, ILE5211L, LEU2213W, LYS2214W, LYS5201L, TRP5198L, VAL5210L
• L-X: ALA3133X, ALA3165X, ALA3166X, ALA3170X, ALA3176X, ALA5020L, ALA5022L, ALA5027L, ALA5163L, ALA5164L, ALA5165L, ALA5169L, ARG3019X, ARG3168X, ARG3194X, ARG5019L, ARG5167L, ASN3029X, ASN3164X, ASN5024L, ASN5208L, ASN5209L, ASP302X, ASP3135X, ASP3167X, ASP3169X, ASP3196X, ASP5017L, ASP5168L, ASP5192L, GLN3023X, GLN3136X, GLN3195X, GLN5029L, GLU5195L, GLY3001X, GLY3021X, GLY3026X, GLY308X, GLY3131X, GLY3173X, GLY3175X, GLY5023L, GLY5132L, GLY5172L, GLY5173L, GLY5194L, GLY5212L, HIS5166L, HIS5191L, ILE306X, ILE5211L, LEU3018X, LEU3020X, LEU3025X, LEU3171X, LEU3191X, LEU5162L, LEU5196L, LYS3030X, LYS3192X, LYS5201L, MET3193X, PHE5135L, PHE5197L, PHE5207L, SER3022X, SER3024X, SER3028X, SER304X, SER305X, SER3134X, SER3172X, SER5018L, SER5028L, SER5131L, SER5171L, SER5174L, THR3132X, THR5021L, THR5030L, THR5134L, TRP3174X, TRP5025L, TRP5198L, TYR3190X, TYR5170L, VAL3027X, VAL5026L, VAL5193L, VAL5210L
• L-Y: ALA4131Y, ALA5136L, ALA5163L, ALA5164L, ALA5169L, ARG4007Y, ARG4148Y, ARG4170Y, ARG5159L, ARG5167L, ASN5143L, ASN5208L, ASN5209L, ASP4144Y, ASP4150Y, ASP5125L, ASP5141L, ASP5168L, CYS4163Y, CYS5128L, GLN4117Y, GLN4165Y, GLN5133L, GLU4126Y, GLU4166Y, GLU5203L, GLU5204L, GLY4130Y, GLY4136Y, GLY5132L, GLY5138L, GLY5205L, HIS4145Y, HIS4146Y, HIS5166L, ILE5126L, ILE5211L, LEU4127Y, LEU4142Y, LEU4143Y, LEU4162Y, LEU4167Y, LEU5140L, LEU5156L, LEU5162L, LYS4169Y, LYS5201L, MET4171Y, PHE4137Y, PHE4140Y, PHE5006L, PHE5127L, PHE5135L, PHE5197L, PHE5207L, PRO4128Y, PRO4149Y, PRO4172Y, SER4135Y, SER4141Y, SER5131L, SER5142L, SER5160L, SER5206L, THR4139Y, THR5134L, TYR4129Y, TYR4134Y, TYR4138Y, TYR4147Y, TYR5137L, TYR5144L, TYR5155L, TYR5170L, VAL4125Y, VAL5139L, VAL5200L, VAL5210L
• M-N: ALA6049M, ALA6050M, ALA6054M, ALA7089N, ALA7135N, ALA7140N, ARG6019M, ARG6029M, ARG6058M, ARG6212M, ARG7095N, ARG7096N, ARG7120N, ARG7148N, ARG7153N, ASN6020M, ASN6027M, ASN603M, ASN608M, ASN7100N, ASN7104N, ASN7123N, ASN7144N, ASP6023M, ASP6051M, ASP6053M, ASP607M, ASP6191M, ASP7152N, ASP7156N, GLN601M, GLN702N, GLN703N, GLN7094N, GLU6031M, GLU6209M, GLU7086N, GLU7154N, GLY6047M, GLY6052M, GLY606M, GLY7126N, GLY7137N, GLY7139N, HIS7141N, ILE6021M, ILE6026M, LEU6055M, LEU6210M, LEU7102N, LEU7124N, LEU7125N, LEU7134N, LYS6057M, LYS6091M, LYS7007N, LYS7098N, MET7092N, MET7099N, MET7142N, PHE602M, PHE6035M, PHE6048M, PHE6093M, PHE6094M, PHE6207M, PRO6032M, PRO604M, PRO6095M, PRO704N, PRO7101N, PRO7132N, PRO7145N, SER6025M, SER6028M, SER7097N, SER7130N, SER7131N, SER7155N, THR6018M, THR6022M, THR701N, THR7090N, THR7128N, THR7133N, TRP7103N, TYR6024M, TYR6030M, TYR605M, TYR6096M, TYR6097M, TYR7087N, TYR7093N, TYR7121N, TYR7129N, VAL7122N, VAL7127N, VAL7151N
• M-W: ALA2027W, ALA2161W, ALA2211W, ALA6132M, ALA6133M, ALA6182M, ARG2019W, ARG2196W, ARG2207W, ARG6019M, ARG6029M, ARG6176M, ARG6185M, ARG6212M, ASN2030W, ASN2165W, ASN2172W, ASN2194W, ASN6020M, ASN6027M, ASN608M, ASN6143M, ASN6149M, ASN6156M, ASP2017W, ASP2028W, ASP2166W, ASP6023M, ASP607M, ASP6177M, ASP6191M, ASP6213M, GLN2022W, GLN2160W, GLN2200W, GLN6144M, GLN6150M, GLN6188M, GLU2197W, GLU2198W, GLU6152M, GLU6169M, GLU6170M, GLU6184M, GLU6206M, GLU6209M, GLY2023W, GLY2130W, GLY2162W, GLY2168W, GLY2170W, GLY2208W, GLY609M, GLY6154M, GLY6157M, GLY6190M, HIS6186M, ILE2025W, ILE2163W, ILE6021M, ILE6026M, ILE6172M, ILE6187M, LEU2167W, LEU2213W, LEU6136M, LEU6141M, LEU6166M, LEU6174M, LEU6210M, LYS2029W, LYS2199W, LYS2201W, LYS2204W, LYS6148M, LYS6158M, LYS6160M, LYS6161M, LYS6173M, LYS6211M, PHE2205W, PHE6140M, PHE6147M, PHE6179M, PRO2024W, PRO2193W, PRO2206W, PRO6153M, SER2020W, SER2129W, SER2169W, SER2171W, SER2202W, SER6025M, SER6135M, SER6178M, SER6181M, THR2001W, THR2021W, THR2209W, THR2210W, THR6022M, THR6155M, THR6180M, THR6183M, TRP2164W, TYR2203W, TYR6024M, TYR6151M, TYR6208M, VAL2026W, VAL2195W, VAL2212W, VAL6145M, VAL6159M, VAL6171M, VAL6175M, VAL6189M
• M-X: ALA3124X, ALA3133X, ALA3161X, ALA3165X, ALA3166X, ALA6129M, ALA6132M, ALA6133M, ALA6134M, ALA6182M, ARG3168X, ARG3194X, ARG6128M, ARG6185M, ASN3164X, ASN6143M, ASN6146M, ASN6149M, ASN6156M, ASP3122X, ASP3126X, ASP3135X, ASP3167X, ASP3169X, ASP6142M, ASP6177M, CYS3141X, CYS6127M, GLN3136X, GLN3160X, GLN6126M, GLN6144M, GLN6150M, GLU3142X, GLU3156X, GLU6125M, GLU6184M, GLY3139X, GLY6157M, HIS6186M, ILE3128X, ILE6137M, LEU3137X, LEU3144X, LEU3162X, LEU3163X, LEU3191X, LEU6136M, LEU6141M, LEU6174M, LYS3125X, LYS3192X, LYS6148M, LYS6158M, LYS6160M, MET3140X, MET3193X, MET6138M, PHE3127X, PHE3138X, PHE6140M, PHE6147M, PHE6179M, PRO6139M, PRO6153M, SER3134X, SER3143X, SER3159X, SER6135M, SER6178M, SER6181M, THR3157X, THR6180M, THR6183M, TYR3145X, TYR6151M, VAL3129X, VAL6159M
• N-O: ARG1077O, ARG1105O, ASP1111O, ASP1231O, GLN7223N, GLU1148O, GLY1109O, GLY7221N, ILE7225N, LYS7224N, THR1078O, THR7222N, TYR1106O, TYR1108O, TYR1110O, TYR7220N
• N-V: ALA1024V, ALA1027V, ALA1049V, ALA1054V, ALA1056V, ALA1162V, ALA7181N, ALA7214N, ARG1019V, ARG1029V, ARG1036V, ARG1045V, ARG1174V, ARG1185V, ARG7027N, ARG7174N, ARG7179N, ARG7182N, ARG7185N, ASN1028V, ASN7029N, ASN7208N, ASP1032V, ASP1039V, ASP1057V, ASP1166V, ASP1191V, ASP7180N, ASP7212N, ASP7216N, CYS1043V, GLN1053V, GLN1060V, GLN1161V, GLN1195V, GLN7205N, GLN7223N, GLU1184V, GLU1192V, GLU1194V, GLU7207N, GLY1023V, GLY1130V, GLY1167V, GLY1170V, GLY1171V, GLY7023N, GLY7219N, GLY7221N, HIS1038V, HIS7141N, ILE1026V, ILE1055V, ILE1058V, ILE1163V, ILE1173V, ILE1187V, ILE7217N, ILE7225N, LEU1034V, LEU1178V, LEU1186V, LEU7019N, LEU7025N, LEU7026N, LEU7176N, LYS1033V, LYS1164V, LYS7210N, LYS7215N, LYS7218N, LYS7224N, MET7142N, MET7209N, PHE1133V, PHE1188V, PHE7028N, PHE7138N, PHE7213N, PRO1190V, SER1018V, SER1129V, SER1168V, SER1169V, SER7021N, SER7024N, SER7183N, THR1020V, THR1021V, THR1022V, THR1031V, THR1035V, THR1052V, THR1132V, THR7001N, THR7222N, TRP1042V, TRP1165V, TRP7211N, TYR1025V, TYR1189V, TYR1193V, TYR7022N, TYR7177N, TYR7178N, TYR7220N, VAL1030V, VAL1037V, VAL1172V, VAL1176V, VAL1183V, VAL7175N, VAL7206N
• N-W: ALA2133W, ALA2134W, ALA2136W, ALA2158W, ALA2161W, ALA7140N, ALA7143N, ALA7172N, ALA7214N, ARG2075W, ARG7148N, ARG7174N, ARG7179N, ASN2165W, ASN7144N, ASN7171N, ASP2120W, ASP2145W, ASP2157W, ASP2166W, ASP7152N, ASP7180N, ASP7212N, ASP7216N, GLN2081W, GLN2085W, GLN2144W, GLN2160W, GLN7223N, GLU2139W, GLY2117W, GLY2122W, GLY2130W, GLY2162W, GLY7139N, GLY7219N, GLY7221N, HIS2109W, HIS2141W, HIS7141N, ILE2113W, ILE7217N, LEU2080W, LEU2110W, LEU2125W, LEU2132W, LEU2138W, LEU2154W, LEU2167W, LEU7146N, LEU7147N, LEU7176N, LYS2007W, LYS2084W, LYS2143W, LYS2153W, LYS7149N, LYS7210N, LYS7215N, LYS7218N, LYS7224N, MET2135W, MET7142N, PHE2111W, PHE7138N, PHE7213N, PRO7145N, SER2078W, SER2112W, SER2118W, SER2126W, SER2129W, SER2131W, SER2140W, THR2106W, THR2119W, THR7133N, THR7222N, TRP2142W, TRP2164W, TRP7211N, TYR2123W, TYR2124W, TYR7178N, TYR7220N, VAL2076W, VAL2077W, VAL2121W, VAL2137W, VAL7175N
• O-P: ALA1044O, ALA1118O, ALA1122O, ALA1132O, ALA1160O, ALA1168O, ALA1170O, ALA2024P, ALA2027P, ALA2056P, ALA2121P, ARG1024O, ARG1046O, ARG1120O, ARG1131O, ARG2083P, ARG2090P, ARG2128P, ASN1123O, ASN1181O, ASN1184O, ASP1013O, ASP1115O, ASP1158O, ASP1192O, ASP2022P, ASP2081P, ASP2087P, GLN1126O, GLN1130O, GLN1175O, GLN1176O, GLN2020P, GLN2030P, GLU1022O, GLU1183O, GLU2059P, GLY1023O, GLY1161O, GLY1165O, GLY2079P, GLY2125P, GLY2126P, GLY2131P, HIS1185O, ILE1016O, ILE1018O, ILE1127O, ILE1154O, ILE1178O, ILE1191O, ILE2021P, LEU1025O, LEU1043O, LEU1124O, LEU1150O, LEU1182O, LEU2025P, LEU2055P, LEU2061P, LEU2085P, LYS1107O, LYS1119O, LYS1156O, LYS1167O, LYS1187O, LYS2029P, LYS2049P, LYS2050P, LYS2063P, LYS2088P, LYS2091P, MET1121O, MET1134O, MET2057P, MET2078P, MET2118P, PHE1019O, PHE1186O, PHE2130P, PRO1021O, PRO1152O, PRO1159O, PRO2054P, PRO2080P, PRO2129P, PRO2152P, SER1020O, SER1125O, SER1153O, SER2051P, SER2052P, SER2053P, SER2058P, SER2062P, SER2065P, SER2124P, THR1017O, THR1129O, THR1157O, THR1169O, THR1179O, THR1180O, THR2026P, THR2060P, TYR1128O, TYR1133O, TYR1155O, TYR1162O, TYR1163O, TYR1166O, TYR2023P, TYR2075P, TYR2082P, VAL1028O, VAL1045O, VAL1164O, VAL2028P, VAL2084P, VAL2086P, VAL2127P, VAL2132P
• O-U: ALA1010O, ALA1031O, ALA1034O, ALA1090O, ALA1093O, ALA1094O, ALA1132O, ALA7112U, ALA7121U, ALA7145U, ALA7162U, ALA7163U, ALA7171U, ALA7173U, ARG1014O, ARG1091O, ARG1096O, ARG1131O, ARG1135O, ARG7019U, ARG7114U, ARG7168U, ASN1036O, ASN1092O, ASN1221O, ASN7011U, ASN7020U, ASN7126U, ASP1013O, ASP1061O, ASP1065O, ASP1089O, ASP7008U, ASP7017U, ASP7113U, ASP7180U, GLN1027O, GLN1037O, GLN7117U, GLN7120U, GLN7169U, GLU1029O, GLU7024U, GLU7151U, GLU7174U, GLU7176U, GLY1011O, GLY1085O, GLY1138O, GLY7004U, GLY7006U, GLY7018U, GLY7038U, GLY7116U, GLY7154U, GLY7158U, GLY7161U, HIS1015O, HIS7122U, HIS7146U, ILE1016O, ILE1040O, ILE1087O, ILE7039U, LEU1063O, LEU1064O, LEU1095O, LEU1137O, LEU7009U, LEU7124U, LEU7147U, LEU7150U, LEU7175U, LEU7178U, LYS1033O, LYS1062O, LYS1098O, LYS7040U, LYS7160U, LYS7172U, LYS7177U, MET1134O, MET7149U, PHE1032O, PHE1073O, PHE7014U, PRO1060O, PRO1066O, PRO1086O, PRO1088O, PRO1136O, PRO1159O, PRO7016U, PRO7109U, PRO7152U, SER1070O, SER7010U, SER7012U, SER7015U, SER7127U, SER7153U, SER7155U, THR1017O, THR1035O, THR1038O, THR1067O, THR1068O, THR7005U, THR7123U, TRP7157U, TYR1012O, TYR1026O, TYR1030O, TYR1071O, TYR1128O, TYR1133O, TYR7007U, TYR7125U, TYR7148U, TYR7156U, TYR7159U, VAL1028O, VAL1059O, VAL1069O, VAL1139O, VAL7013U, VAL7023U, VAL7119U, VAL7179U
• O-V: ALA1054V, ALA1056V, ALA1094O, ALA1097O, ALA1099O, ALA1101O, ALA1102O, ARG1036V, ARG1077O, ARG1096O, ARG1105O, ASP1039V, ASP1057V, ASP1111O, CYS1074O, GLN1053V, GLN1060V, GLN1069V, GLU1064V, GLU1100O, GLU1103O, GLY1071V, HIS1038V, HIS1062V, ILE1055V, ILE1058V, ILE1075O, LEU1063V, LEU1065V, LEU1095O, LYS1098O, LYS1107O, LYS1232O, MET1112O, PHE1073O, PHE1104O, SER1068V, SER1076O, THR1067V, THR1072V, THR1078O, TYR1061V, TYR1066V, TYR1070V, TYR1106O, VAL1037V, VAL1059V
• O-W: ALA1118O, ALA1122O, ALA2079W, ARG1105O, ARG1120O, ARG2072W, ARG2075W, ASN1123O, ASN2062W, ASP1111O, ASP1115O, ASP1147O, ASP2104W, CYS1114O, GLN2081W, GLN2085W, GLU1100O, GLU1148O, GLU1149O, GLU2073W, GLY1109O, GLY1151O, HIS2066W, ILE1079O, ILE2059W, ILE2063W, LEU1117O, LEU1124O, LEU1150O, LEU2065W, LEU2068W, LEU2080W, LEU2083W, LYS1107O, LYS1119O, LYS2084W, MET1112O, MET1121O, MET2082W, PHE1104O, PHE2088W, PRO1113O, PRO2074W, PRO2105W, SER1145O, SER1153O, SER2067W, SER2071W, SER2078W, THR2070W, THR2106W, TYR1106O, TYR1108O, TYR1110O, TYR1155O, TYR1163O, TYR2069W, VAL1116O, VAL2076W, VAL2077W
• O-7: ARG1014O, ARG1024O, ARG8677, ASP7677, ASP7697, ASP8097, GLU1029O, GLU1177O, GLU1183O, GLU8137, LYS1033O, LYS1174O, LYS8127, LYS8147, LYS8707
• P-Q: ALA2115P, ALA2161P, ALA2163P, ALA2171P, ALA3082Q, ARG2178P, ARG3050Q, ARG3092Q, ARG3129Q, ASN2143P, ASN2180P, ASN3089Q, ASP3060Q, ASP3083Q, ASP3209Q, GLN2119P, GLN2123P, GLN2149P, GLN3059Q, GLU2113P, GLU2120P, GLU2176P, GLU3058Q, GLU3064Q, GLU3085Q, GLY2036P, GLY2125P, GLY2154P, GLY3127Q, GLY3132Q, ILE2021P, ILE2037P, ILE2117P, ILE3086Q, LEU2109P, LEU2147P, LEU2175P, LEU3056Q, LEU3057Q, LEU3080Q, LEU3128Q, LYS2038P, LYS2108P, LYS2116P, LYS2160P, LYS2172P, LYS2177P, LYS3051Q, PHE2145P, PHE2157P, PHE2174P, PHE3131Q, PRO2158P, PRO3130Q, SER2112P, SER2124P, SER2146P, SER2153P, SER2155P, SER3054Q, SER3062Q, THR2122P, THR2162P, THR2173P, THR3053Q, THR3055Q, THR3061Q, THR3063Q, THR3081Q, TRP2159P, TRP2179P, TYR2148P, TYR2156P, TYR3067Q, TYR3122Q
• P-W: ALA2093P, ALA2184W, ARG2036W, ARG2083P, ARG2090P, ARG2099P, ARG2188W, ASN2062W, ASP2087P, ASP2183W, ASP2220P, ASP2230P, CYS2176W, GLN2057W, GLU2064W, GLU2073W, GLU2185W, GLY2060W, GLY2102P, GLY2223P, GLY2226P, HIS2035W, HIS2066W, HIS2094P, ILE2037W, ILE2041W, ILE2059W, ILE2063W, ILE2227P, LEU2034W, LEU2058W, LEU2061P, LEU2065W, LEU2066P, LEU2067P, LEU2068W, LEU2187W, LEU2221P, LEU2222P, LYS2040W, LYS2088P, LYS2091P, LYS2098P, LYS2182W, MET2082W, MET2178W, PRO2039W, PRO2069P, PRO2219P, PRO2228P, PRO2233P, SER2038W, SER2061W, SER2062P, SER2065P, SER2067W, SER2071W, SER2089P, THR2056W, THR2060P, THR2068P, THR2070W, THR2095P, THR2225P, THR2229P, TRP2042W, TYR2069W, TYR2101P, TYR2104P, TYR2186W, TYR2224P, VAL2084P, VAL2086P, VAL2092P, VAL2103W, VAL2175W, VAL2177W
• P-X: ALA3072X, ARG2099P, ARG3071X, ASN2143P, ASN3104X, ASP2140P, GLN3080X, GLU2103P, GLU2113P, GLU2141P, GLU3069X, GLU3070X, GLU3074X, GLU3076X, GLU3088X, GLU3123X, GLY2102P, GLY2144P, HIS3039X, ILE2100P, ILE3073X, ILE3121X, LEU2109P, LEU3064X, LEU3067X, LEU3081X, LYS2098P, LYS2108P, LYS3061X, LYS3068X, LYS3106X, LYS3109X, PHE2142P, PHE3078X, PRO2105P, PRO2106P, PRO3075X, SER2096P, SER2112P, SER3083X, SER3084X, SER3085X, SER3105X, SER3107X, THR2229P, THR3062X, THR3077X, THR3079X, TYR2097P, TYR2101P, TYR2104P, TYR2148P, TYR3065X, VAL3082X
• P-7: ARG10037, ARG8597, GLU10077, GLU2201P, GLU2203P, GLU8637, HIS10047, LYS2050P, LYS2197P
• P-8: GLU11958, LYS2177P
• Q-R: ALA3040Q, ALA3162Q, ALA3172Q, ALA4023R, ALA4026R, ALA4080R, ARG3018Q, ARG3113Q, ARG3114Q, ARG3143Q, ARG4029R, ARG4048R, ARG4058R, ARG4083R, ARG4090R, ARG4127R, ASN3152Q, ASN3156Q, ASN4079R, ASP3117Q, ASP3179Q, ASP3182Q, ASP4056R, ASP4081R, GLN3120Q, GLN3124Q, GLN3147Q, GLN3173Q, GLN3177Q, GLN4019R, GLN4055R, GLN4117R, GLU3016Q, GLU3023Q, GLU3109Q, GLU4021R, GLU4025R, GLU4087R, GLY3017Q, GLY3037Q, GLY3121Q, GLY3126Q, GLY3127Q, GLY3145Q, GLY3155Q, GLY3159Q, GLY4077R, GLY4124R, GLY4125R, GLY4130R, HIS3125Q, ILE3038Q, ILE3044Q, ILE3118Q, ILE3163Q, ILE4059R, ILE4084R, ILE4086R, LEU3019Q, LEU3115Q, LEU3128Q, LEU3148Q, LEU3175Q, LEU3176Q, LEU3192Q, LEU4024R, LEU4052R, LEU4054R, LEU4078R, LEU4085R, LYS3119Q, LYS3161Q, LYS3181Q, LYS4028R, LYS4053R, LYS4088R, MET3039Q, MET3178Q, PHE4075R, PHE4129R, PRO3015Q, PRO3153Q, PRO4061R, PRO4128R, SER3014Q, SER3041Q, SER3116Q, SER3151Q, SER3154Q, SER3164Q, SER4062R, SER4082R, THR3123Q, THR3158Q, THR3174Q, THR4051R, THR4057R, THR4060R, TRP3160Q, TYR3020Q, TYR3122Q, TYR3144Q, TYR3146Q, TYR3149Q, TYR3157Q, TYR3180Q, TYR4022R, TYR4120R, VAL3022Q, VAL3108Q, VAL3112Q, VAL4027R, VAL4116R, VAL4126R, VAL4131R
• Q-W: ALA3220Q, ASN2219W, ASP2222W, ASP3071Q, CYS2221W, GLN3227Q, GLU3224Q, LYS3068Q, LYS3072Q, TYR3226Q, VAL3225Q
• Q-X: ALA3091Q, ALA3095Q, ARG3059X, ARG3092Q, ASN3055X, ASN3063X, ASN3070Q, ASN3089Q, ASN3097Q, ASN3103Q, ASP3071Q, ASP3105Q, GLN3096Q, GLN3227Q, GLU3056X, GLU3069X, GLU3070X, GLU3104Q, HIS3094Q, ILE3073Q, ILE3088Q, ILE3093Q, ILE3229Q, LEU3054X, LEU3064X, LEU3067X, LEU3069Q, LEU3099Q, LYS3061X, LYS3066X, LYS3068Q, LYS3068X, LYS3072Q, LYS3100Q, MET3057X, PHE3058X, SER3062Q, THR3052X, THR3053X, THR3061Q, THR3062X, THR3063Q, THR3090Q, THR3101Q, TYR3060X, TYR3065X, TYR3067Q, TYR3098Q, TYR3102Q
• Q-Y: ALA4078Y, ALA4088Y, ARG3113Q, ARG3143Q, ARG4069Y, ARG4084Y, ASN3097Q, ASN3103Q, ASN4062Y, ASP3105Q, ASP3141Q, ASP3142Q, ASP4071Y, ASP4107Y, GLN4077Y, GLN4085Y, GLU3104Q, GLU3109Q, GLU4070Y, GLU4073Y, GLU4086Y, GLY3145Q, HIS3094Q, ILE3106Q, ILE3110Q, ILE4063Y, LEU3099Q, LEU4074Y, LYS3100Q, LYS4089Y, LYS4109Y, LYS4110Y, LYS4124Y, PHE4082Y, PRO3107Q, PRO4076Y, SER4067Y, SER4075Y, SER4080Y, SER4081Y, THR3101Q, TYR3098Q, TYR3102Q, TYR3140Q, TYR3144Q, TYR4066Y, TYR4072Y, VAL4079Y, VAL4083Y
• Q-8: ASP13838, ASP3179Q, ASP3202Q, ASP3209Q, GLU13758, GLU14978, HIS14958, LYS14948, LYS3199Q
• R-S: ALA4114R, ALA4161R, ALA5083S, ALA5085S, ARG4111R, ARG4119R, ARG4172R, ARG4181R, ARG5086S, ARG5093S, ARG5136S, ASN4178R, ASN5215S, ASP4180R, ASP5062S, ASP5084S, GLN4118R, GLN4122R, GLN4149R, GLN4162R, GLN5023S, GLU4107R, GLU4151R, GLU4173R, GLU4176R, GLU5060S, GLU5065S, GLU5090S, GLU5125S, GLY4035R, GLY4115R, GLY4124R, GLY4125R, GLY4154R, GLY5080S, GLY5139S, ILE4017R, ILE4155R, ILE5064S, LEU4147R, LEU4175R, LEU5058S, LEU5059S, LEU5081S, LEU5133S, LYS4037R, LYS4146R, LYS4177R, MET5088S, MET5134S, PHE4174R, PHE5138S, PRO4145R, PRO5057S, PRO5137S, SER4123R, SER4153R, SER4157R, SER4158R, SER4160R, SER5056S, SER5061S, SER5063S, SER5087S, SER5135S, THR4110R, THR4121R, THR4163R, THR5055S, THR5082S, TRP4159R, TYR4148R, TYR4156R, TYR4179R, VAL4020R, VAL4036R, VAL4126R, VAL4171R, VAL5012S, VAL5068S
• R-Y: ALA4056Y, ALA4061Y, ALA4089R, ALA4093R, ARG4035Y, ARG4069Y, ARG4090R, ARG4097R, ASN4062Y, ASP4068R, ASP4071Y, GLN4054Y, GLN4060Y, GLN4064Y, GLN4094R, GLU4057Y, GLU4070Y, GLU4087R, GLU4092R, GLU4101R, HIS4070R, HIS4096R, ILE4059Y, ILE4063Y, ILE4067R, ILE4068Y, ILE4086R, ILE4221R, LEU4065Y, LEU4098R, LYS4066R, LYS4088R, PHE4055Y, SER4062R, SER4065R, SER4067Y, SER4069R, SER4095R, THR4099R, TYR4058Y, TYR4066Y, VAL4053Y, VAL4071R, VAL4091R
• R-Z: ALA5077Z, ALA5078Z, ALA5079Z, ARG4097R, ARG4111R, ARG4141R, ARG5069Z, ARG5106Z, ARG5121Z, ASN5085Z, ASP4102R, ASP4139R, ASP4142R, CYS5063Z, GLN5062Z, GLU4101R, GLU4107R, GLU5070Z, GLU5072Z, GLU5108Z, GLY5109Z, HIS4096R, HIS5066Z, ILE5074Z, ILE5082Z, LEU4098R, LEU4100R, LEU4109R, LEU5068Z, LEU5083Z, LYS5071Z, LYS5081Z, LYS5107Z, LYS5123Z, PRO4140R, SER5075Z, SER5080Z, THR4099R, THR4105R, THR5105Z, THR5111Z, TYR4108R, TYR4148R, TYR4156R, TYR5113Z, VAL4104R, VAL5076Z
• R-8: ARG17988, ARG4049R, ARG4166R, ASP16668, ASP16678, ASP17158, ASP17958, GLN17608, GLN4204R, GLU16238, GLU17118, GLU17188, GLU17538, GLU4173R, GLU4176R, GLU4201R, GLU4237R, HIS17148, HIS17598, LYS16688, LYS18738, LYS4053R, LYS4169R, LYS4177R, LYS4208R, LYS4240R
• S-T: ALA5041S, ALA5127S, ALA5169S, ALA5171S, ALA5179S, ALA5181S, ALA6025T, ALA6028T, ALA6053T, ALA6078T, ALA6081T, ARG5005S, ARG5020S, ARG5122S, ARG5132S, ARG5166S, ARG6003T, ARG6051T, ARG6082T, ARG6089T, ARG6126T, ASN5168S, ASN5185S, ASN6004T, ASN6005T, ASN6052T, ASN6086T, ASN6119T, ASP5118S, ASP6007T, ASP6009T, ASP6054T, ASP6080T, CYS5117S, GLN5114S, GLN5180S, GLN6021T, GLN6031T, GLN6060T, GLN6090T, GLN6117T, GLN6121T, GLU5007S, GLU5018S, GLU5025S, GLU5110S, GLU5125S, GLU5130S, GLU5182S, GLU5186S, GLU6023T, GLU6027T, GLU6055T, GLY5011S, GLY5019S, GLY5039S, GLY5124S, GLY5126S, GLY5129S, GLY5162S, GLY6008T, GLY6076T, GLY6124T, GLY6125T, GLY6129T, HIS5157S, HIS5188S, ILE5040S, ILE6029T, ILE6064T, LEU5021S, LEU5119S, LEU5121S, LEU5155S, LEU5183S, LEU5184S, LEU5191S, LEU5199S, LEU6026T, LEU6056T, LEU6074T, LEU6077T, LYS5170S, LYS6030T, LYS6050T, LYS6061T, LYS6115T, LYS6118T, MET6001T, PHE5015S, PHE5123S, PHE5156S, PHE5164S, PHE6002T, PHE6020T, PRO5017S, PRO6079T, PRO6127T, PRO6149T, SER5006S, SER5013S, SER5016S, SER5111S, SER5115S, SER5128S, SER5161S, SER6057T, SER6058T, SER6122T, THR5014S, THR5163S, THR6010T, THR6120T, TRP5187S, TYR5008S, TYR5165S, TYR5167S, TYR6006T, TYR6024T, TYR6059T, TYR6087T, TYR6123T, TYR6128T, VAL5012S, VAL5024S, VAL6022T, VAL6083T, VAL6130T
• S-Z: ALA5092S, ALA5095S, ALA5096S, ARG5064Z, ARG5069Z, ARG5072S, ARG5086S, ARG5093S, ASN5100S, ASP5062S, ASP5071S, ASP5104S, ASP5106S, CYS5063Z, GLN5053Z, GLN5062Z, GLU5056Z, GLU5065S, GLU5067Z, GLU5069S, GLU5070Z, GLU5090S, GLY5060Z, HIS5066Z, HIS5073S, HIS5091S, HIS5099S, ILE5067S, ILE5070S, ILE5074S, ILE5089S, ILE5230S, LEU5059Z, LEU5065Z, LEU5068Z, LEU5101S, LYS5071Z, PHE5054Z, PHE5228S, PRO5039Z, SER5061Z, SER5063S, THR5057Z, THR5094S, THR5098S, TRP5055Z, TRP5058Z, TYR5102S, VAL5068S, VAL5097S
• S-1: ALA5096S, ALA5149S, ALA60801, ALA60811, ARG60821, ASN5100S, ASN5108S, ASN60711, ASN60781, ASN60831, ASP5104S, ASP5106S, ASP5148S, ASP5150S, ASP5151S, ASP60691, GLN5114S, GLN60851, GLU5105S, GLU5110S, GLU61071, GLY60901, HIS5099S, HIS60671, HIS60701, HIS60861, ILE5107S, ILE60771, ILE60841, LEU5101S, LEU5112S, LEU60751, LEU60871, LYS60731, LYS60741, PHE60591, PHE60681, SER5111S, SER5115S, SER60621, SER60761, SER60791, THR5098S, TRP60651, TYR5102S, TYR5103S, TYR60661, TYR60891, TYR61141, TYR61221, VAL5097S, VAL5109S, VAL60631
• S-7: ARG5005S, GLU5007S, HIS5237, LYS5897
• S-8: ARG21398, ARG5005S, ARG5020S, ARG5053S, ASP19198, ASP21168, ASP5009S, ASP5213S, GLU20058, GLU5007S, GLU5018S, GLU5025S, GLU5051S, GLU5159S, GLU5177S, GLU5209S, GLU5210S, GLY5019S, HIS19178, LEU5003S, LYS19188, LYS21118, LYS21128, LYS5211S, SER21088, TYR20748, TYR21428
• T-U: ALA6116T, ALA6142T, ALA6160T, ALA6168T, ALA7026U, ALA7029U, ARG6018T, ARG6039T, ARG6107T, ARG6174T, ARG7085U, ARG7092U, ARG7129U, ASN6005T, ASN6119T, ASN6152T, ASN7011U, ASN7032U, ASN7063U, ASN7089U, ASN7126U, ASP6007T, ASP6009T, ASP6114T, ASP6138T, ASP6177T, ASP7008U, ASP7083U, CYS6113T, GLN6117T, GLN6121T, GLN6148T, GLN7022U, GLN7067U, GLU6106T, GLU6146T, GLU6155T, GLU6173T, GLU7024U, GLU7031U, GLU7093U, GLY6008T, GLY6017T, GLY6037T, GLY6109T, GLY6124T, GLY6141T, GLY6151T, GLY6158T, GLY7006U, GLY7079U, GLY7084U, GLY7132U, HIS6110T, HIS6143T, HIS7086U, HIS7122U, ILE6180T, ILE7053U, ILE7081U, LEU6019T, LEU6038T, LEU6111T, LEU6112T, LEU6144T, LEU6145T, LEU6156T, LEU6172T, LEU6176T, LEU7009U, LEU7052U, LEU7057U, LEU7058U, LEU7080U, LEU7087U, LYS6115T, LYS6118T, LYS6169T, LYS7028U, LYS7051U, LYS7056U, LYS7062U, LYS7065U, LYS7209U, PHE6013T, PHE6147T, PHE6179T, PHE7021U, PHE7131U, PRO6015T, PRO6149T, PRO7060U, PRO7082U, PRO7130U, PRO7152U, SER6014T, SER6122T, SER6140T, SER6150T, SER7010U, SER7012U, SER7055U, SER7127U, THR6010T, THR6012T, THR6016T, THR6120T, THR6154T, THR6159T, THR6170T, THR6175T, THR7054U, TYR6006T, TYR6123T, TYR6157T, TYR6171T, TYR7007U, TYR7025U, TYR7077U, TYR7118U, TYR7125U, VAL6011T, VAL6022T, VAL6105T, VAL6153T, VAL7023U, VAL7027U, VAL7030U, VAL7059U, VAL7064U, VAL7088U, VAL7128U, VAL7133U
• T-1: ARG60581, ARG6082T, ARG6089T, ASN60611, ASN60711, ASN6086T, ASN6093T, ASN6100T, ASP6067T, ASP60691, ASP60721, CYS6066T, CYS6092T, GLN6090T, GLN6091T, GLU6068T, HIS60671, HIS6069T, HIS60701, ILE6064T, ILE6224T, LEU6088T, LEU6097T, LEU6103T, LYS60571, LYS60601, LYS6061T, LYS60641, LYS6065T, LYS6102T, MET6070T, PHE60681, PHE6099T, SER60621, SER6085T, SER6095T, SER6096T, THR6223T, TRP60651, TYR6087T, TYR6094T, VAL6098T
• T-2: ALA6104T, ALA70672, ALA70732, ALA70752, ALA70782, ALA70892, ARG6101T, ARG6107T, ASN6100T, ASN70662, ASN70702, ASN71142, ASP6114T, ASP6138T, ASP70692, GLN70942, GLN71122, GLU6106T, GLU70652, GLU70762, GLU70772, GLU70802, GLU70862, GLY6141T, HIS6069T, HIS6110T, HIS6143T, ILE70842, LEU6097T, LEU6103T, LEU70592, LEU70622, LEU70722, LEU70792, LEU70882, LYS6102T, LYS6139T, PHE6099T, PHE70852, PHE71182, PRO70712, PRO70812, SER6095T, SER6096T, SER6140T, SER70822, SER71132, THR70902, TYR6094T, TYR70682, TYR70832, TYR70872, VAL6098T, VAL6105T, VAL70912
• T-7: ARG6003T, ARG6357, ARG6377, ASN6005T, GLN5877, HIS6367, LYS5897, MET6001T
• T-8: ALA21438, ALA6078T, ARG20488, ARG20948, ARG6003T, ARG6164T, ARG6202T, ASP21168, ASP21328, ASP6203T, GLN20498, GLN6031T, GLU20478, GLU21318, GLU21348, GLU6027T, GLU6055T, GLU6204T, GLY6076T, LEU21378, LYS20538, LYS21118, LYS6030T, LYS6062T, PHE6002T, TYR21418
• U-V: ALA1078V, ALA1079V, ALA7110U, ARG7114U, ASN1106V, ASN7143U, ASP1103V, ASP7113U, GLN1069V, GLN7117U, GLU1076V, GLU1084V, GLU1088V, GLU7094U, GLY1071V, HIS1062V, ILE1058V, ILE7106U, LEU1063V, LEU1065V, LEU1085V, LEU7101U, LYS1083V, LYS1105V, LYS7099U, LYS7100U, LYS7103U, LYS7142U, PHE1082V, PHE7098U, PHE7111U, PRO1073V, PRO7105U, PRO7107U, PRO7109U, SER1074V, SER1080V, SER7097U, THR1067V, THR1072V, THR1075V, THR1077V, THR7104U, TYR1061V, TYR1066V, TYR1070V, TYR1087V, TYR1111V, TYR7102U, TYR7156U, VAL1059V, VAL1081V, VAL1119V
• U-2: ALA70672, ALA70732, ALA70752, ALA7095U, ALA7096U, ARG70572, ARG7071U, ARG7085U, ARG7092U, ASN7063U, ASN70662, ASN70702, ASN7089U, ASP70612, ASP70692, ASP7070U, ASP70742, GLN70532, GLN7061U, GLN7067U, GLU70562, GLU70652, GLU7093U, GLU7214U, GLY70382, GLY7091U, HIS70542, HIS7072U, HIS7227U, ILE7066U, ILE7073U, LEU70582, LEU70592, LEU70622, LEU70722, LEU70792, LEU7101U, LYS70602, LYS7062U, LYS7099U, LYS7100U, LYS7103U, LYS7228U, LYS7231U, PHE7229U, PRO70712, PRO7105U, THR70642, TYR70682, VAL70372, VAL70632, VAL7064U, VAL7068U, VAL7069U, VAL7088U
• U-7: ASN6767, ASP6777, ASP7008U, ASP7017U, GLU8137
• V-W: ALA1024V, ALA1027V, ALA1049V, ALA1050V, ALA1054V, ALA1056V, ALA2115W, ALA2133W, ALA2134W, ALA2136W, ARG1029V, ARG1045V, ARG1174V, ASN1028V, ASN1089V, ASN1092V, ASP1032V, ASP1051V, ASP1057V, ASP2120W, GLN1053V, GLN1060V, GLN2081W, GLN2085W, GLN2091W, GLU2139W, GLY2092W, GLY2117W, GLY2122W, HIS2114W, HIS2116W, ILE1026V, ILE1055V, ILE1058V, ILE2113W, LEU1093V, LEU2080W, LEU2087W, LEU2125W, LEU2127W, LEU2132W, LEU2138W, LYS2084W, MET2135W, PHE2088W, SER1048V, SER2112W, SER2118W, SER2126W, SER2131W, SER2140W, THR1020V, THR1022V, THR1031V, THR1052V, THR1094V, THR2119W, TRP2142W, TYR1025V, TYR1061V, TYR2097W, TYR2123W, TYR2124W, VAL1030V, VAL2121W
• V-2: ALA1125V, ALA1127V, ARG70272, ARG70572, ARG70952, ASN70292, ASN71002, ASP1091V, ASP1139V, ASP70482, ASP70512, CYS1086V, GLN7022, GLN7032, GLN70532, GLU1084V, GLU1088V, GLU70562, GLY1096V, GLY1116V, GLY1117V, GLY1128V, GLY70202, GLY70302, HIS1120V, HIS70542, ILE1003V, ILE1097V, ILE1098V, ILE1113V, ILE1126V, ILE70492, ILE7052, ILE70552, LEU1093V, LEU1115V, LEU1122V, LEU70252, LEU70262, LEU70582, LEU71022, LYS1083V, LYS1090V, LYS1121V, MET70522, MET70992, PHE70282, PRO1114V, PRO7042, PRO71012, SER1046V, SER1080V, SER1118V, SER1129V, SER1131V, SER70502, THR1094V, THR1112V, THR1132V, THR7012, THR7072, TRP71032, TYR1087V, TYR1124V, TYR1135V, TYR70222, VAL1119V, VAL70312, VAL7062
• W-X: ALA2027W, ALA2032W, ALA2049W, ALA2050W, ALA2054W, ALA2096W, ALA2211W, ALA3072X, ALA3124X, ALA3161X, ALA3176X, ARG2188W, ARG2196W, ARG2207W, ARG3090X, ARG3189X, ASN2030W, ASN2189W, ASN2219W, ASN3148X, ASN3164X, ASP2028W, ASP2051W, ASP2222W, ASP3116X, ASP3122X, ASP3126X, ASP3135X, ASP3153X, ASP3184X, CYS2031W, CYS2221W, CYS3120X, CYS3141X, GLN2022W, GLN2057W, GLN3080X, GLN3136X, GLN3160X, GLN3195X, GLU2053W, GLU2215W, GLU3032X, GLU3123X, GLU3142X, GLU3146X, GLU3150X, GLU3152X, GLU3156X, GLU3185X, GLY2092W, GLY2095W, GLY2208W, GLY3038X, GLY3114X, GLY3119X, GLY3131X, GLY3139X, GLY3175X, HIS2035W, HIS2086W, HIS2093W, HIS3036X, HIS3039X, ILE2025W, ILE2094W, ILE2217W, ILE2220W, ILE3103X, ILE3118X, ILE3121X, ILE3128X, ILE3158X, ILE3180X, ILE3181X, LEU2058W, LEU2213W, LEU3018X, LEU3117X, LEU3144X, LEU3149X, LEU3154X, LEU3162X, LEU3163X, LEU3191X, LYS2029W, LYS2199W, LYS2201W, LYS2204W, LYS2214W, LYS3030X, LYS3066X, LYS3125X, LYS3182X, LYS3183X, LYS3188X, LYS3192X, MET3006X, MET3140X, MET3193X, PHE2205W, PHE3041X, PHE3091X, PHE3115X, PHE3127X, PHE3138X, PHE3155X, PRO2024W, PRO2206W, PRO3147X, PRO3151X, SER2020W, SER2202W, SER2216W, SER3083X, SER3084X, SER3130X, SER3134X, SER3143X, SER3159X, THR2048W, THR2052W, THR2209W, THR2210W, THR3157X, TRP3174X, TYR2090W, TYR2203W, TYR3037X, TYR3087X, TYR3145X, TYR3179X, TYR3190X, VAL2026W, VAL2055W, VAL2195W, VAL2212W, VAL2218W, VAL3040X, VAL3129X, VAL3177X, VAL3178X, VAL3186X, VAL3187X
• X-Y: ALA3048X, ALA4088Y, ALA4131Y, ARG3059X, ARG3089X, ARG4007Y, ARG4084Y, ARG4092Y, ASN3029X, ASN3055X, ASN307X, ASP3050X, ASP4119Y, ASP4144Y, GLN3023X, GLN4077Y, GLN4085Y, GLN4117Y, GLU3032X, GLU3056X, GLU4126Y, GLY3021X, GLY3026X, GLY3092X, GLY4122Y, GLY4130Y, GLY4133Y, GLY4136Y, HIS4132Y, ILE306X, ILE4091Y, ILE4118Y, LEU3018X, LEU3020X, LEU3025X, LEU3047X, LEU3054X, LEU3117X, LEU4087Y, LEU4102Y, LEU4121Y, LEU4127Y, LYS3030X, LYS4089Y, LYS4124Y, MET3057X, PHE3031X, PHE3091X, PHE3095X, PHE4082Y, PHE4137Y, PHE4140Y, PRO303X, PRO3093X, PRO4128Y, SER3022X, SER3024X, SER3028X, SER4081Y, SER4135Y, SER4141Y, THR3049X, THR3052X, THR3053X, THR4123Y, THR4139Y, TRP3174X, TYR3094X, TYR4120Y, TYR4129Y, TYR4134Y, TYR4138Y, VAL3027X, VAL3051X, VAL3096X, VAL4125Y
• Y-Z: ALA4019Y, ALA4049Y, ALA5093Z, ARG4022Y, ARG4035Y, ARG4094Y, ARG4095Y, ARG5121Z, ASN5085Z, ASP4029Y, ASP4031Y, ASP4032Y, ASP4051Y, ASP5116Z, ASP5118Z, ASP5125Z, ASP5141Z, CYS5128Z, GLN4054Y, GLN4098Y, GLN5089Z, GLN5133Z, GLU4048Y, GLU4057Y, GLY4023Y, GLY4050Y, GLY5092Z, GLY5119Z, GLY5124Z, GLY5130Z, GLY5138Z, ILE4024Y, ILE5126Z, LEU4027Y, LEU5122Z, LYS4028Y, LYS4033Y, LYS5081Z, LYS5091Z, LYS5123Z, MET5100Z, PHE4055Y, PHE5127Z, PHE5135Z, PRO4096Y, SER4025Y, SER4030Y, SER5084Z, SER5117Z, SER5131Z, THR4021Y, THR4052Y, THR5120Z, THR5134Z, TYR4058Y, TYR4097Y, TYR5088Z, TYR5090Z, TYR5113Z, TYR5114Z, TYR5137Z, VAL4020Y, VAL4026Y, VAL4053Y, VAL4099Y, VAL5087Z, VAL5129Z
• Z-1: ALA5020Z, ALA5022Z, ALA5027Z, ALA5049Z, ALA5050Z, ALA5093Z, ALA61291, ALA61331, ALA61341, ARG5033Z, ARG60821, ARG60921, ARG61241, ARG61281, ASN61461, ASN61491, ASP5051Z, ASP5192Z, ASP61171, ASP61421, CYS5052Z, CYS61271, GLN5029Z, GLN5053Z, GLN60851, GLN61261, GLU5036Z, GLU5056Z, GLU5195Z, GLU5202Z, GLU61231, GLU61251, GLY5048Z, GLY5060Z, GLY5092Z, GLY5094Z, GLY5173Z, GLY5194Z, GLY5212Z, GLY60901, GLY61201, GLY61301, GLY61311, HIS60861, HIS60991, ILE5035Z, ILE5037Z, ILE60841, ILE61371, LEU5086Z, LEU5095Z, LEU60871, LEU60881, LEU61361, LEU61411, LYS5032Z, LYS61481, LYS61581, LYS61601, MET5045Z, MET5097Z, MET61381, PHE5054Z, PHE60931, PHE61161, PHE61401, PRO61181, PRO61391, SER5018Z, SER5028Z, SER5061Z, SER5096Z, SER5117Z, SER61151, SER61211, SER61351, THR5021Z, THR5030Z, THR5057Z, TRP5025Z, TRP5055Z, TRP5058Z, TRP5198Z, TYR5090Z, TYR60891, TYR61221, TYR61511, VAL5026Z, VAL5031Z, VAL5034Z, VAL5087Z, VAL61191
• 1-2: ALA60491, ALA60501, ALA60541, ALA70892, ALA71352, ALA71402, ARG60191, ARG60291, ARG60581, ARG62121, ARG70952, ARG70962, ARG71202, ARG71482, ARG71532, ASN60201, ASN60271, ASN6031, ASN6081, ASN71002, ASN71042, ASN71232, ASN71442, ASP60231, ASP60511, ASP60531, ASP6071, ASP61911, ASP71522, ASP71562, GLN6011, GLN7022, GLN7032, GLN70942, GLU60311, GLU62091, GLU70862, GLU71542, GLY60471, GLY60521, GLY6061, GLY71262, GLY71372, GLY71392, HIS71412, ILE60211, ILE60261, LEU60551, LEU62101, LEU71022, LEU71242, LEU71252, LEU71342, LYS60571, LYS60911, LYS70072, LYS70982, MET70922, MET70992, MET71422, PHE6021, PHE60351, PHE60481, PHE60931, PHE60941, PHE62071, PHE70852, PRO60321, PRO6041, PRO60951, PRO7042, PRO71012, PRO71322, PRO71452, SER60251, SER60281, SER70972, SER71302, SER71312, SER71552, THR60181, THR60221, THR7012, THR70902, THR71282, THR71332, TRP71032, TYR60241, TYR60301, TYR6051, TYR60961, TYR60971, TYR70872, TYR70932, TYR71212, TYR71292, VAL71222, VAL71272, VAL71512
• 3-4: ALA1373, ALA1503, ALA2584, ARG1103, ARG1143, ARG1173, ARG2604, ARG2974, ARG9594, ASN1033, ASN1463, ASN2394, ASN2414, ASN2454, ASN2494, ASP1353, ASP2544, ASP2944, ASP2954, ASP2964, ASP923, CYS1413, CYS2504, GLN1363, GLN2764, GLU1193, GLU1233, GLU1243, GLU1313, GLU2464, HIS1003, HIS1333, HIS1423, HIS2424, HIS2524, HIS2834, HIS883, ILE1043, ILE1223, ILE1493, ILE1513, LEU1403, LEU1443, LEU1473, LEU1543, LEU2474, LEU2514, LEU2594, LEU2634, LEU2704, LEU2904, LEU863, LEU913, LYS2484, LYS2774, LYS9624, MET1013, MET2864, PHE1123, PHE1203, PHE2534, PHE2554, PRO1073, PRO1183, PRO1213, PRO2564, SER1093, SER1133, SER1153, SER1323, SER1523, SER1533, SER2624, SER2924, THR1303, THR2444, THR2984, THR903, TRP1113, TRP2434, TYR1053, TYR1393, TYR1483, TYR2674, TYR2694, TYR893, TYR933, VAL1163, VAL1433, VAL1453, VAL2404, VAL2574, VAL2664, VAL2734
• 3-5: ARG12635, ARG853, ASP11485, ASP1353, ASP14145, GLU1193, GLU1233, GLU12455, GLU1313, GLU843, HIS883
• 4-5: ALA15265, ARG10034, ARG11745, ARG11785, ARG12495, ARG12635, ARG12715, ARG18285, ARG3334, ARG4804, ARG6504, ARG8834, ARG9364, ARG9594, ASN11715, ASN11935, ASN5264, ASP10314, ASP10334, ASP11485, ASP12145, ASP12245, ASP15185, ASP15655, ASP18305, ASP18325, ASP2964, ASP3284, ASP3304, ASP4064, ASP4654, ASP4664, ASP8804, ASP9344, GLN12175, GLN2744, GLU12185, GLU12455, GLU20235, GLU5094, GLU5194, GLU6064, GLU7874, GLU9314, GLU9854, GLU9894, GLU9964, GLY18355, HIS10214, HIS11735, HIS12065, HIS12425, HIS12605, HIS12675, HIS20195, HIS2524, HIS5464, HIS9214, HIS9644, LEU10294, LYS10364, LYS11635, LYS11855, LYS12725, LYS13945, LYS16865, LYS19425, LYS20225, LYS2774, LYS5164, LYS5434, LYS9434, PRO12465, PRO14095, SER10274, SER19765, SER2624, TYR11545, TYR20745, TYR4124, VAL14015
• 6-7: ARG1146, ARG2977, ARG9597, ASP2547, ASP2957, ASP2967, ASP9617, GLU1196, GLU1236, GLU1246, HIS1006, HIS2527, LYS9627, PHE1126, THR2987, VAL1166, VAL2577
• 6-8: ARG12638, ARG856, ASP11488, ASP1356, ASP14148, GLU1196, GLU1236, GLU12458, GLU1316, GLU846, HIS886, LEU14108, TYR896
• 7-8: ALA15268, ARG10037, ARG11748, ARG11788, ARG12498, ARG12638, ARG12718, ARG18288, ARG3337, ARG4807, ARG6507, ARG8837, ARG9367, ARG9597, ASN11718, ASN11938, ASN5267, ASP10317, ASP10337, ASP11488, ASP12148, ASP15188, ASP15658, ASP18308, ASP18328, ASP2967, ASP3287, ASP3307, ASP4067, ASP4657, ASP4667, ASP9347, CYS9357, GLN12388, GLN2747, GLN4677, GLU12188, GLU12458, GLU20238, GLU5097, GLU5197, GLU6067, GLU7877, GLU9317, GLU9857, GLU9897, GLU9967, GLY18338, GLY18358, HIS10217, HIS11738, HIS12068, HIS12428, HIS12608, HIS12678, HIS20198, HIS2527, HIS5467, HIS9217, HIS9647, LYS10367, LYS11638, LYS11858, LYS12728, LYS13948, LYS16868, LYS19428, LYS20228, LYS2777, LYS5167, LYS5437, LYS9437, PRO12468, SER12418, SER19768, THR12508, TYR11698, TYR20748, TYR3317, TYR4127, VAL14018