1VLQ

crystal structure of acetyl xylan esterase (tm0077) from thermotoga maritima at 2.10 a resolution

• Total interactions analyzed: 66
• Total true interactions: 28
• Strongest Interaction:
  • Chains: H-I
  • Int. Res.: 112
  • Norm. En. per Res.: -4.3697
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-34.5633	6.8288	-225.107	-252.8415	98	7	5	8746	0	32	31
A-C	-15.9967	-7.9055	-124.056	-147.9582	53	3	4	4487	0	11	10
A-E	-18.9958	-8.7068	-128.0	-155.7026	53	4	2	4437	1	12	10
A-F	-77.1078	3.3472	-384.182	-457.9426	113	8	2	13367	0	36	28
B-C	-90.7991	4.6006	-394.711	-480.9095	115	11	2	13362	0	35	29
B-D	-22.4432	-6.9063	-129.412	-158.7616	51	3	1	4327	0	12	10
B-F	-12.2983	-7.1906	-133.91	-153.3989	52	4	3	4567	0	12	10
C-D	-28.9099	5.2823	-231.05	-254.6776	100	7	5	8884	0	32	29
C-E	-11.8371	-8.5389	-134.971	-155.347	52	3	4	4577	1	11	10
D-E	-79.7144	3.4484	-388.848	-465.114	111	11	2	13252	0	35	29
D-F	-14.3159	-6.7587	-134.181	-155.2556	56	7	2	4537	0	11	10
D-J	0.0	-26.4552	-23.1662	-49.6214	43	0	0	1517	1	30	45
D-K	-9.0919	3.821	-27.1038	-32.3748	36	1	1	1548	2	8	16
E-F	-29.6485	5.5951	-227.577	-251.6304	99	5	5	8823	0	32	30
E-J	-18.1061	2.257	-29.4263	-45.2754	37	1	1	1643	2	8	15
E-K	0.0	0.0	-0.776	-0.776	18	0	0	197	0	16	15
G-H	-29.4551	7.8317	-229.719	-251.3424	97	7	5	8882	0	33	30
G-I	-19.5813	-7.3994	-122.145	-149.1257	51	5	3	4420	0	11	10
G-K	-14.1747	-13.2214	-130.68	-158.0761	52	3	2	4437	2	12	10
G-L	-90.9087	4.448	-389.716	-476.1767	112	10	2	13369	0	36	28
H-I	-100.9245	4.1576	-392.645	-489.4119	112	8	2	13502	0	36	28
H-J	-17.2641	-7.4224	-132.882	-157.5685	54	1	4	4553	0	12	10
H-L	-20.4717	-5.6755	-128.91	-155.0572	52	4	4	4510	0	12	10
I-J	-29.6084	5.21	-228.055	-252.4535	99	3	5	8809	0	32	30
I-K	-19.1264	-6.9705	-133.632	-159.7289	56	3	4	4622	0	11	10
J-K	-86.9902	1.7093	-393.161	-478.4419	113	10	2	13477	0	34	29
J-L	-3.7256	-5.4578	-119.184	-128.3675	55	4	3	4305	0	11	10
K-L	-28.4182	7.2551	-227.918	-249.0811	99	6	5	8872	0	33	29

Interface residues

• A-B: ALA311A, ALA311B, ARG181B, ASN301A, ASN301B, ASP101A, ASP101B, GLN310A, GLN310B, GLU304A, GLU304B, GLU313A, GLU313B, GLU323A, GLU323B, GLU55A, GLU55B, GLU79A, GLU79B, GLU80A, GLU80B, GLY109A, GLY109B, GLY123A, GLY123B, GLY306A, GLY306B, GLY307A, GLY307B, GLY97A, GLY97B, HIS100A, HIS100B, HIS50A, HIS50B, LEU103A, LEU103B, LEU125A, LEU125B, LEU51A, LEU51B, LEU74A, LEU74B, LEU78A, LEU78B, LEU83A, LEU83B, LYS126A, LYS126B, LYS316A, LYS316B, LYS319A, LYS319B, LYS320A, LYS320B, LYS52A, LYS52B, LYS77A, LYS77B, PHE104A, PHE104B, PHE309A, PHE309B, PHE317B, PHE98A, PHE98B, PRO106A, PRO106B, PRO76A, PRO76B, PRO84A, PRO84B, PRO99A, PRO99B, SER107A, SER107B, SER308A, SER308B, SER49A, SER49B, THR53A, THR53B, TRP102A, TRP102B, TRP105A, TRP105B, TRP124A, TRP124B, TYR110A, TYR110B, VAL312A, VAL312B, VAL315A, VAL315B, VAL54A, VAL54B, VAL75A, VAL75B
• A-C: ALA220C, ALA2A, ALA2C, ARG218C, ARG219C, ARG240C, ASN234C, ASN275C, ASN301A, ASN302A, ASP225C, ASP241C, ASP274A, ASP5A, GLN222C, GLN310A, GLU243C, GLU244C, GLU304A, GLY271A, GLY305A, GLY306A, GLY307A, HIS239C, HIS303A, ILE232C, ILE297A, LEU223C, LEU236C, LEU272A, LEU6A, LEU8A, LYS237C, LYS242C, PHE217C, PHE235C, PHE247C, PHE309A, PHE3A, PHE3C, PHE4A, PHE4C, PRO299A, PRO7A, SER308A, THR226C, THR233C, THR238C, TYR298A, TYR300A, VAL221C, VAL224C, VAL246C
• A-E: ALA220A, ALA2A, ALA2E, ALA311E, ARG218A, ARG219A, ARG240A, ASN234A, ASN275A, ASN275E, ASN301E, ASN302E, ASP225A, ASP241A, ASP274E, ASP5E, GLN222A, GLN310E, GLU243A, GLU244A, GLU304E, GLY271E, GLY305E, GLY306E, GLY307E, HIS239A, HIS303E, ILE232A, ILE297E, LEU223A, LEU236A, LEU8E, LYS237A, LYS242A, PHE217A, PHE235A, PHE247A, PHE309E, PHE3A, PHE3E, PHE4A, PHE4E, PRO299E, PRO7E, SER308E, THR226A, THR233A, THR238A, TYR298E, TYR300E, VAL221A, VAL224A, VAL246A
• A-F: ARG118A, ARG118F, ARG147A, ARG147F, ARG159A, ARG159F, ARG240A, ARG240F, ARG68F, ASN234A, ASN234F, ASN93A, ASN93F, ASP116A, ASP116F, ASP128A, ASP128F, ASP131A, ASP131F, ASP138A, ASP138F, ASP241A, ASP241F, GLN120A, GLN120F, GLN140A, GLN140F, GLN67A, GLN67F, GLU134A, GLU134F, GLU231A, GLU231F, GLY119A, GLY119F, GLY121A, GLY121F, GLY123A, GLY123F, GLY127A, GLY127F, GLY135A, GLY135F, GLY143A, GLY143F, GLY148A, GLY148F, GLY94A, GLY94F, GLY95A, GLY95F, GLY97A, GLY97F, HIS227A, HIS227F, HIS239A, HIS239F, ILE149A, ILE149F, LEU125A, LEU125F, LEU150A, LEU150F, LEU236A, LEU236F, LYS126A, LYS126F, LYS237A, LYS237F, LYS242A, LYS242F, PHE144A, PHE144F, PHE235A, PHE235F, PHE98A, PHE98F, PRO130A, PRO130F, PRO133A, PRO133F, PRO136A, PRO136F, PRO139A, PRO139F, PRO142A, PRO142F, PRO228A, PRO228F, SER122A, SER122F, THR117A, THR117F, THR129A, THR129F, THR146A, THR146F, THR233A, THR233F, THR238A, THR238F, TRP124A, TRP124F, TYR132A, TYR132F, TYR141A, TYR141F, TYR156A, TYR156F, TYR92A, TYR92F, VAL137A, VAL137F
• B-C: ARG118B, ARG118C, ARG147B, ARG147C, ARG159B, ARG159C, ARG240B, ARG240C, ARG68B, ARG68C, ASN234B, ASN234C, ASN93B, ASN93C, ASP116B, ASP116C, ASP128B, ASP128C, ASP131B, ASP131C, ASP138B, ASP138C, ASP241B, ASP241C, GLN120B, GLN120C, GLN140B, GLN140C, GLN67B, GLN67C, GLU134B, GLU134C, GLU231B, GLU231C, GLY119B, GLY119C, GLY121B, GLY121C, GLY123B, GLY123C, GLY127B, GLY127C, GLY135B, GLY135C, GLY143B, GLY143C, GLY148C, GLY94B, GLY94C, GLY95B, GLY95C, GLY97B, GLY97C, HIS227B, HIS227C, HIS239B, HIS239C, ILE149B, ILE149C, LEU125B, LEU125C, LEU150B, LEU150C, LEU236B, LEU236C, LYS126B, LYS126C, LYS237B, LYS237C, LYS242B, LYS242C, LYS70B, LYS70C, PHE144B, PHE144C, PHE235B, PHE235C, PHE98B, PHE98C, PRO130B, PRO130C, PRO133B, PRO133C, PRO136B, PRO136C, PRO139B, PRO139C, PRO142B, PRO142C, PRO228B, PRO228C, SER122B, SER122C, THR117B, THR117C, THR129B, THR129C, THR146B, THR146C, THR233B, THR233C, THR238B, THR238C, TRP124B, TRP124C, TYR132B, TYR132C, TYR141B, TYR141C, TYR156B, TYR156C, TYR92B, TYR92C, VAL137B, VAL137C
• B-D: ALA220B, ALA2B, ALA2D, ALA311D, ARG218B, ARG219B, ARG240B, ARG296D, ASN234B, ASN275B, ASN275D, ASN301D, ASN302D, ASP225B, ASP241B, ASP274D, GLN222B, GLN310D, GLU243B, GLU244B, GLU304D, GLY271D, GLY305D, GLY306D, GLY307D, HIS239B, HIS303D, ILE232B, ILE297D, LEU223B, LEU236B, LYS237B, LYS242B, PHE217B, PHE235B, PHE247B, PHE309D, PHE3B, PHE3D, PHE4B, PHE4D, PRO299D, SER308D, THR226B, THR233B, THR238B, TYR298D, TYR300D, VAL221B, VAL224B, VAL246B
• B-F: ALA220F, ALA2B, ALA2F, ALA311B, ARG218F, ARG219F, ARG240F, ARG296B, ASN234F, ASN275B, ASN275F, ASN301B, ASN302B, ASP225F, ASP241F, ASP274B, GLN222F, GLN310B, GLU243F, GLU244F, GLU304B, GLY271B, GLY305B, GLY306B, GLY307B, HIS239F, HIS303B, ILE232F, ILE297B, LEU223F, LEU236F, LYS237F, LYS242F, PHE217F, PHE235F, PHE247F, PHE309B, PHE3B, PHE3F, PHE4B, PHE4F, PRO299B, PRO7B, SER308B, THR226F, THR233F, THR238F, TYR298B, TYR300B, VAL221F, VAL224F, VAL246F
• C-D: ALA311C, ALA311D, ARG181C, ASN301C, ASN301D, ASP101C, ASP101D, GLN310C, GLN310D, GLU304C, GLU304D, GLU313C, GLU313D, GLU323C, GLU323D, GLU48D, GLU55C, GLU55D, GLU79C, GLU79D, GLU80C, GLU80D, GLY109C, GLY109D, GLY123C, GLY123D, GLY306C, GLY306D, GLY307C, GLY307D, GLY97C, GLY97D, HIS100C, HIS100D, HIS50C, HIS50D, LEU103C, LEU103D, LEU125C, LEU125D, LEU51C, LEU51D, LEU74C, LEU74D, LEU78C, LEU78D, LEU83C, LEU83D, LYS126C, LYS126D, LYS316C, LYS316D, LYS319C, LYS319D, LYS320C, LYS320D, LYS52C, LYS52D, LYS77C, LYS77D, PHE104C, PHE104D, PHE309C, PHE309D, PHE317C, PHE317D, PHE98C, PHE98D, PRO106C, PRO106D, PRO76C, PRO76D, PRO84C, PRO84D, PRO99C, PRO99D, SER107C, SER107D, SER308C, SER308D, SER49C, SER49D, THR53C, THR53D, TRP102C, TRP102D, TRP105C, TRP105D, TRP124C, TRP124D, TYR110C, TYR110D, VAL312C, VAL312D, VAL315C, VAL315D, VAL54C, VAL54D, VAL75C, VAL75D
• C-E: ALA220E, ALA2C, ALA2E, ALA311C, ARG218E, ARG219E, ARG240E, ASN234E, ASN275E, ASN301C, ASN302C, ASP225E, ASP241E, ASP274C, GLN222E, GLN310C, GLU243E, GLU244E, GLU304C, GLY271C, GLY305C, GLY306C, GLY307C, HIS239E, HIS303C, ILE232E, ILE297C, LEU223E, LEU236E, LEU272C, LEU8C, LYS237E, LYS242E, PHE217E, PHE235E, PHE247E, PHE309C, PHE3C, PHE3E, PHE4C, PHE4E, PRO299C, PRO7C, SER308C, THR226E, THR233E, THR238E, TYR298C, TYR300C, VAL221E, VAL224E, VAL246E
• D-E: ARG118D, ARG118E, ARG147D, ARG147E, ARG159D, ARG159E, ARG240D, ARG240E, ARG68D, ARG68E, ASN234D, ASN234E, ASN93D, ASN93E, ASP116D, ASP116E, ASP128D, ASP128E, ASP131D, ASP131E, ASP138D, ASP138E, ASP241D, ASP241E, GLN120D, GLN120E, GLN140D, GLN140E, GLN67D, GLN67E, GLU134D, GLU231D, GLU231E, GLY119D, GLY119E, GLY121D, GLY121E, GLY123D, GLY123E, GLY127D, GLY127E, GLY135D, GLY135E, GLY143D, GLY143E, GLY94D, GLY94E, GLY95D, GLY95E, GLY97D, GLY97E, HIS227D, HIS227E, HIS239D, HIS239E, ILE149D, ILE149E, LEU125D, LEU125E, LEU150D, LEU150E, LEU236D, LEU236E, LYS126D, LYS126E, LYS237D, LYS237E, LYS242D, LYS242E, PHE144D, PHE144E, PHE235D, PHE235E, PHE98D, PHE98E, PRO130D, PRO130E, PRO133D, PRO133E, PRO136D, PRO136E, PRO139D, PRO139E, PRO142D, PRO142E, PRO228D, PRO228E, SER122D, SER122E, THR117D, THR117E, THR129D, THR129E, THR146D, THR146E, THR233D, THR233E, THR238D, THR238E, TRP124D, TRP124E, TYR132D, TYR132E, TYR141D, TYR141E, TYR156D, TYR156E, TYR92D, TYR92E, VAL137D, VAL137E
• D-F: ALA220D, ALA2D, ALA2F, ALA311F, ARG218D, ARG219D, ARG240D, ARG296F, ASN234D, ASN275D, ASN275F, ASN301F, ASN302F, ASP225D, ASP241D, ASP274F, ASP5F, GLN222D, GLN310F, GLU243D, GLU244D, GLU304F, GLY271F, GLY305F, GLY306F, GLY307F, HIS239D, HIS303F, ILE232D, ILE297F, LEU223D, LEU236D, LEU272F, LEU6F, LEU8F, LYS237D, LYS242D, PHE217D, PHE235D, PHE247D, PHE309F, PHE3D, PHE3F, PHE4D, PHE4F, PRO299F, PRO7F, SER308F, THR226D, THR233D, THR238D, TYR298F, TYR300F, VAL221D, VAL224D, VAL246D
• D-J: ALA33D, ARG153D, ARG153J, ARG158D, ARG158J, ARG248D, ARG248J, ARG65D, ARG65J, ASP138D, ASP151D, ASP151J, ASP23J, GLU134D, GLU134J, GLU26D, GLU26J, GLU30D, GLU30J, GLU34D, GLU34J, GLY135D, GLY135J, GLY66D, GLY66J, ILE245D, ILE245J, LEU150D, LEU150J, LYS37D, LYS37J, PHE38D, PHE38J, PRO133J, PRO136D, PRO136J, PRO152D, PRO152J, PRO39D, PRO39J, THR154D, THR154J, TYR64D
• D-K: ARG65D, ARG68D, ARG68K, ASP128K, ASP41D, ASP41K, ASP58D, GLN67K, GLU45D, GLU45K, GLY66D, GLY66K, ILE69K, LEU40D, LEU40K, LYS70D, LYS70K, PHE38D, PHE38K, PHE44D, PHE61K, PRO130D, PRO130K, PRO39D, PRO39K, PRO42D, PRO42K, SER62D, SER62K, THR60D, THR60K, TYR132D, TYR132K, VAL43D, VAL43K, VAL59D
• E-F: ALA311E, ALA311F, ARG181E, ARG181F, ASN301E, ASN301F, ASP101E, ASP101F, GLN310E, GLN310F, GLU304E, GLU304F, GLU313E, GLU313F, GLU323E, GLU48F, GLU55E, GLU55F, GLU79E, GLU79F, GLU80E, GLU80F, GLY109E, GLY109F, GLY123E, GLY123F, GLY306E, GLY306F, GLY307E, GLY307F, GLY97E, GLY97F, HIS100E, HIS100F, HIS50E, HIS50F, LEU103E, LEU103F, LEU125E, LEU125F, LEU51E, LEU51F, LEU74E, LEU74F, LEU78E, LEU78F, LEU83E, LEU83F, LYS126E, LYS126F, LYS316E, LYS316F, LYS319E, LYS319F, LYS320E, LYS320F, LYS52E, LYS52F, LYS77E, LYS77F, PHE104E, PHE104F, PHE309E, PHE309F, PHE317F, PHE98E, PHE98F, PRO106E, PRO106F, PRO76E, PRO76F, PRO84E, PRO84F, PRO99E, PRO99F, SER107E, SER107F, SER308E, SER308F, SER49E, SER49F, THR53E, THR53F, TRP102E, TRP102F, TRP105E, TRP105F, TRP124E, TRP124F, TYR110E, TYR110F, VAL312E, VAL312F, VAL315E, VAL315F, VAL54E, VAL54F, VAL75E, VAL75F
• E-J: ARG65J, ARG68E, ARG68J, ASP128E, ASP41E, ASP41J, ASP58J, GLN67E, GLU45E, GLU45J, GLY66E, GLY66J, ILE69E, LEU40E, LEU40J, LYS70E, LYS70J, PHE38E, PHE38J, PHE44J, PHE61E, PRO130E, PRO130J, PRO39E, PRO39J, PRO42E, PRO42J, SER62E, SER62J, THR129E, THR60E, THR60J, TYR132E, TYR132J, VAL43E, VAL43J, VAL59J
• E-K: ARG153E, ARG153K, ARG65E, ARG65K, ASP151E, ASP151K, GLU30E, GLU30K, GLU34E, GLU34K, GLY135E, GLY135K, LYS37E, LYS37K, PHE38E, PHE38K, PRO136E, PRO136K
• G-H: ALA311G, ALA311H, ASN301G, ASN301H, ASP101G, ASP101H, GLN310G, GLN310H, GLU304G, GLU304H, GLU313G, GLU313H, GLU323G, GLU323H, GLU48G, GLU55G, GLU55H, GLU79G, GLU79H, GLU80G, GLU80H, GLY109G, GLY109H, GLY123G, GLY123H, GLY306G, GLY306H, GLY307G, GLY307H, GLY97G, GLY97H, HIS100G, HIS100H, HIS50G, HIS50H, LEU103G, LEU103H, LEU125G, LEU125H, LEU51G, LEU51H, LEU74G, LEU74H, LEU78G, LEU78H, LEU83G, LEU83H, LYS126G, LYS126H, LYS316G, LYS316H, LYS319G, LYS319H, LYS320G, LYS320H, LYS52G, LYS52H, LYS77G, LYS77H, PHE104G, PHE104H, PHE309G, PHE309H, PHE98G, PHE98H, PRO106G, PRO106H, PRO76G, PRO76H, PRO84G, PRO84H, PRO99G, PRO99H, SER107G, SER107H, SER308G, SER308H, SER49G, SER49H, THR53G, THR53H, TRP102G, TRP102H, TRP105G, TRP105H, TRP124G, TRP124H, TYR110G, TYR110H, VAL312G, VAL312H, VAL315G, VAL315H, VAL54G, VAL54H, VAL75G, VAL75H
• G-I: ALA2G, ALA2I, ALA311G, ARG218I, ARG219I, ARG240I, ARG296G, ASN234I, ASN275I, ASN301G, ASN302G, ASP225I, ASP241I, ASP274G, GLN222I, GLN310G, GLU243I, GLU244I, GLU304G, GLY271G, GLY305G, GLY306G, GLY307G, HIS239I, HIS303G, ILE232I, ILE297G, LEU223I, LEU236I, LEU8G, LYS237I, LYS242I, PHE217I, PHE235I, PHE247I, PHE309G, PHE3G, PHE3I, PHE4G, PHE4I, PRO299G, PRO7G, SER308G, THR226I, THR233I, THR238I, TYR298G, TYR300G, VAL221I, VAL224I, VAL246I
• G-K: ALA220G, ALA2G, ALA2K, ALA311K, ARG218G, ARG219G, ARG240G, ASN234G, ASN275G, ASN301K, ASN302K, ASP225G, ASP241G, ASP274K, ASP5K, GLN222G, GLN310K, GLU243G, GLU244G, GLU304K, GLY271K, GLY305K, GLY306K, GLY307K, HIS239G, HIS303K, ILE232G, ILE297K, LEU223G, LEU236G, LEU8K, LYS237G, LYS242G, PHE217G, PHE235G, PHE247G, PHE309K, PHE3G, PHE3K, PHE4G, PHE4K, PRO299K, PRO7K, SER308K, THR226G, THR233G, THR238G, TYR298K, TYR300K, VAL221G, VAL224G, VAL246G
• G-L: ARG118G, ARG118L, ARG147G, ARG147L, ARG159G, ARG159L, ARG240G, ARG240L, ARG68G, ARG68L, ASN234G, ASN234L, ASN93G, ASN93L, ASP116G, ASP116L, ASP128G, ASP128L, ASP131G, ASP131L, ASP138G, ASP138L, ASP241G, ASP241L, GLN120G, GLN120L, GLN140G, GLN140L, GLN67G, GLN67L, GLU134G, GLU134L, GLU231G, GLU231L, GLY119G, GLY119L, GLY121G, GLY121L, GLY123G, GLY123L, GLY127G, GLY127L, GLY135G, GLY135L, GLY143G, GLY143L, GLY148L, GLY94G, GLY94L, GLY95G, GLY95L, GLY97G, GLY97L, HIS227G, HIS227L, HIS239G, HIS239L, ILE232L, LEU125G, LEU125L, LEU150G, LEU150L, LEU236G, LEU236L, LYS126G, LYS126L, LYS237G, LYS237L, LYS242G, LYS242L, PHE144G, PHE144L, PHE235G, PHE235L, PHE98G, PHE98L, PRO130G, PRO130L, PRO133G, PRO133L, PRO136G, PRO136L, PRO139G, PRO139L, PRO142G, PRO142L, PRO228G, PRO228L, SER122G, SER122L, THR117G, THR117L, THR129G, THR129L, THR146G, THR146L, THR233G, THR233L, THR238G, THR238L, TRP124G, TRP124L, TYR132G, TYR132L, TYR141G, TYR141L, TYR156G, TYR156L, TYR92G, TYR92L, VAL137G, VAL137L
• H-I: ARG118H, ARG118I, ARG147H, ARG147I, ARG159H, ARG159I, ARG240H, ARG240I, ASN234H, ASN234I, ASN93H, ASN93I, ASP116H, ASP116I, ASP128H, ASP128I, ASP131H, ASP131I, ASP138H, ASP138I, ASP241H, ASP241I, GLN120H, GLN120I, GLN140H, GLN140I, GLN67H, GLN67I, GLU134H, GLU134I, GLU231H, GLU231I, GLY119H, GLY119I, GLY121H, GLY121I, GLY123H, GLY123I, GLY127H, GLY127I, GLY135H, GLY135I, GLY143H, GLY143I, GLY148I, GLY94H, GLY94I, GLY95H, GLY95I, GLY97H, GLY97I, HIS227H, HIS227I, HIS239H, HIS239I, ILE149I, LEU125H, LEU125I, LEU150H, LEU150I, LEU236H, LEU236I, LYS126H, LYS126I, LYS237H, LYS237I, LYS242H, LYS242I, LYS70H, LYS70I, PHE144H, PHE144I, PHE235H, PHE235I, PHE98H, PHE98I, PRO130H, PRO130I, PRO133H, PRO133I, PRO136H, PRO136I, PRO139H, PRO139I, PRO142H, PRO142I, PRO228H, PRO228I, SER122H, SER122I, THR117H, THR117I, THR129H, THR129I, THR146H, THR146I, THR233H, THR233I, THR238H, THR238I, TRP124H, TRP124I, TYR132H, TYR132I, TYR141H, TYR141I, TYR156H, TYR156I, TYR92H, TYR92I, VAL137H, VAL137I
• H-J: ALA220H, ALA2H, ALA2J, ALA311J, ARG218H, ARG219H, ARG240H, ARG296J, ASN234H, ASN275H, ASN301J, ASN302J, ASP225H, ASP241H, ASP274J, ASP5J, GLN222H, GLN310J, GLU243H, GLU244H, GLU304J, GLY271J, GLY305J, GLY306J, GLY307J, HIS239H, HIS303J, ILE232H, ILE297J, LEU223H, LEU236H, LEU250H, LEU8J, LYS237H, LYS242H, PHE217H, PHE235H, PHE247H, PHE309J, PHE3H, PHE3J, PHE4H, PHE4J, PRO299J, PRO7J, SER308J, THR226H, THR233H, THR238H, TYR298J, TYR300J, VAL221H, VAL224H, VAL246H
• H-L: ALA220L, ALA2H, ALA2L, ARG218L, ARG219L, ARG240L, ASN234L, ASN275H, ASN275L, ASN301H, ASN302H, ASP225L, ASP241L, ASP274H, ASP5H, GLN222L, GLN310H, GLU243L, GLU244L, GLU304H, GLY271H, GLY305H, GLY306H, GLY307H, HIS239L, HIS303H, ILE232L, ILE297H, LEU223L, LEU236L, LEU8H, LYS237L, LYS242L, PHE217L, PHE235L, PHE247L, PHE309H, PHE3H, PHE3L, PHE4H, PHE4L, PRO299H, PRO7H, SER308H, THR226L, THR233L, THR238L, TYR298H, TYR300H, VAL221L, VAL224L, VAL246L
• I-J: ALA311I, ALA311J, ARG181I, ARG181J, ASN301J, ASP101I, ASP101J, GLN310I, GLN310J, GLU304I, GLU304J, GLU313I, GLU313J, GLU323I, GLU323J, GLU48I, GLU55I, GLU55J, GLU79I, GLU79J, GLU80I, GLU80J, GLY109I, GLY109J, GLY123I, GLY123J, GLY306I, GLY306J, GLY307I, GLY307J, GLY97I, GLY97J, HIS100I, HIS100J, HIS50I, HIS50J, LEU103I, LEU103J, LEU125I, LEU125J, LEU51I, LEU51J, LEU74I, LEU74J, LEU78I, LEU78J, LEU83I, LEU83J, LYS126I, LYS126J, LYS316I, LYS316J, LYS319I, LYS319J, LYS320I, LYS320J, LYS52I, LYS52J, LYS77I, LYS77J, PHE104I, PHE104J, PHE309I, PHE309J, PHE317J, PHE98I, PHE98J, PRO106I, PRO106J, PRO76I, PRO76J, PRO84I, PRO84J, PRO99I, PRO99J, SER107I, SER107J, SER308I, SER308J, SER49I, SER49J, THR53I, THR53J, TRP102I, TRP102J, TRP105I, TRP105J, TRP124I, TRP124J, TYR110I, TYR110J, VAL312I, VAL312J, VAL315I, VAL315J, VAL54I, VAL54J, VAL75I, VAL75J
• I-K: ALA220K, ALA2I, ALA2K, ALA311I, ARG218K, ARG219K, ARG240K, ASN234K, ASN275K, ASN301I, ASN302I, ASP225K, ASP241K, ASP274I, ASP5I, GLN222K, GLN310I, GLU243K, GLU244K, GLU304I, GLU9I, GLY271I, GLY305I, GLY306I, GLY307I, HIS239K, HIS303I, ILE232K, ILE297I, LEU223K, LEU236K, LEU250K, LEU272I, LEU6I, LEU8I, LYS237K, LYS242K, PHE217K, PHE235K, PHE247K, PHE309I, PHE3I, PHE3K, PHE4I, PHE4K, PRO299I, PRO7I, SER308I, THR226K, THR233K, THR238K, TYR298I, TYR300I, VAL221K, VAL224K, VAL246K
• J-K: ARG118J, ARG118K, ARG147J, ARG147K, ARG159J, ARG159K, ARG240J, ARG240K, ARG68J, ASN234J, ASN234K, ASN93J, ASN93K, ASP116J, ASP116K, ASP128J, ASP128K, ASP131J, ASP131K, ASP138J, ASP138K, ASP241J, ASP241K, GLN120J, GLN120K, GLN140J, GLN140K, GLN67J, GLN67K, GLU134J, GLU134K, GLU231J, GLU231K, GLY119J, GLY119K, GLY121J, GLY121K, GLY123J, GLY123K, GLY127J, GLY127K, GLY135J, GLY135K, GLY143J, GLY143K, GLY148J, GLY148K, GLY94J, GLY94K, GLY95J, GLY95K, GLY97J, GLY97K, HIS227J, HIS227K, HIS239J, HIS239K, ILE149J, LEU125J, LEU125K, LEU150J, LEU150K, LEU236J, LEU236K, LYS126J, LYS126K, LYS237J, LYS237K, LYS242J, LYS242K, LYS70J, PHE144J, PHE144K, PHE235J, PHE235K, PHE98J, PHE98K, PRO130J, PRO130K, PRO133J, PRO133K, PRO136J, PRO136K, PRO139J, PRO139K, PRO142J, PRO142K, PRO228J, PRO228K, SER122J, SER122K, THR117J, THR117K, THR129J, THR129K, THR146J, THR146K, THR233J, THR233K, THR238J, THR238K, TRP124J, TRP124K, TYR132J, TYR132K, TYR141J, TYR141K, TYR156J, TYR156K, TYR92J, TYR92K, VAL137J, VAL137K
• J-L: ALA220J, ALA2J, ALA2L, ALA311L, ARG218J, ARG219J, ARG240J, ASN234J, ASN275J, ASN301L, ASN302L, ASP225J, ASP241J, ASP274L, ASP5L, GLN222J, GLN310L, GLU243J, GLU244J, GLU304L, GLU9L, GLY271L, GLY305L, GLY306L, GLY307L, HIS239J, HIS303L, ILE232J, ILE297L, LEU223J, LEU236J, LEU272L, LEU6L, LEU8L, LYS237J, LYS242J, PHE217J, PHE235J, PHE247J, PHE309L, PHE3J, PHE3L, PHE4J, PHE4L, PRO299L, PRO7L, SER308L, THR226J, THR233J, THR238J, TYR298L, TYR300L, VAL221J, VAL224J, VAL246J
• K-L: ALA311K, ALA311L, ARG181K, ASN301K, ASP101K, ASP101L, GLN310K, GLN310L, GLU304K, GLU304L, GLU313K, GLU313L, GLU323K, GLU323L, GLU48K, GLU55K, GLU55L, GLU79K, GLU79L, GLU80K, GLU80L, GLY109K, GLY109L, GLY123K, GLY123L, GLY306K, GLY306L, GLY307K, GLY307L, GLY97K, GLY97L, HIS100K, HIS100L, HIS50K, HIS50L, LEU103K, LEU103L, LEU125K, LEU125L, LEU51K, LEU51L, LEU74K, LEU74L, LEU78K, LEU78L, LEU83K, LEU83L, LYS126K, LYS126L, LYS316K, LYS316L, LYS319K, LYS319L, LYS320K, LYS320L, LYS52K, LYS52L, LYS77K, LYS77L, PHE104K, PHE104L, PHE309K, PHE309L, PHE317K, PHE317L, PHE98K, PHE98L, PRO106K, PRO106L, PRO76K, PRO76L, PRO84K, PRO84L, PRO99K, PRO99L, SER107K, SER107L, SER308K, SER308L, SER49K, SER49L, THR53K, THR53L, TRP102K, TRP102L, TRP105K, TRP105L, TRP124K, TRP124L, TYR110K, TYR110L, VAL312K, VAL312L, VAL315K, VAL315L, VAL54K, VAL54L, VAL75K, VAL75L