1VLF

crystal structure of pyrogallol-phloroglucinol transhydroxylase from pelobacter acidigallici complexed with inhibitor 1,2,4,5-tetrahydroxy-benzene

• Total interactions analyzed: 66
• Total true interactions: 17
• Strongest Interaction:
  • Chains: Q-R
  • Int. Res.: 231
  • Norm. En. per Res.: -4.0315
• Hub Node: M(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
M-N	-126.3459	-130.215	-661.013	-917.5739	236	37	5	24951	11	81	77
M-Q	0.0	0.0	-0.062	-0.062	4	0	0	20	0	10	9
M-R	0.0	-2.1013	-16.2845	-18.3858	13	0	0	513	0	10	6
M-S	-6.3273	26.0653	-106.602	-86.864	91	9	2	5748	3	58	45
M-U	-3.373	12.8383	-24.5571	-15.0918	42	0	0	1437	0	43	42
N-Q	0.0	-1.9493	-15.3214	-17.2707	15	0	0	486	0	9	7
N-S	0.0	-7.7143	-16.9732	-24.6875	22	3	1	1056	0	3	5
O-P	-122.4227	-128.5852	-665.72	-916.7278	235	34	4	24850	10	81	77
P-S	-12.2284	-17.8549	-61.7809	-91.8642	45	5	0	2611	2	24	29
Q-R	-123.6318	-131.7827	-675.873	-931.2874	231	37	4	25064	11	80	78
Q-S	-12.7392	13.8729	-35.9048	-34.771	49	0	0	1883	0	47	46
Q-U	-6.6141	28.4428	-103.153	-81.3243	92	7	3	5774	3	58	44
R-U	0.0	-8.3407	-16.9644	-25.3051	22	3	1	1038	0	3	5
S-T	-122.8192	-129.134	-651.304	-903.2572	232	34	5	24895	9	81	77
U-V	-133.4521	-134.522	-652.015	-919.9891	234	33	5	25018	10	83	79
V-X	-6.5196	0.0			2
W-X	-125.4208	-134.4716			42

Interface residues

• M-N: ALA11N, ALA139N, ALA146N, ALA201N, ALA256M, ALA260M, ALA329M, ALA334M, ALA336M, ALA60M, ALA64M, ARG144N, ARG193N, ARG234M, ARG235M, ARG257M, ARG27M, ARG333M, ARG337M, ARG41N, ARG44N, ARG50N, ARG51N, ARG53N, ARG55M, ARG58N, ARG64N, ARG6M, ARG740M, ARG761M, ARG773M, ASN148N, ASN17N, ASN18N, ASN190N, ASN230N, ASN232M, ASN253M, ASN30N, ASN47N, ASN569M, ASN59N, ASN62N, ASN751M, ASN755M, ASN775M, ASN786M, ASP135N, ASP15N, ASP208N, ASP218M, ASP240M, ASP244M, ASP249M, ASP25N, ASP261M, ASP268N, ASP32M, ASP60N, ASP73M, ASP759M, ASP9N, CYS129N, CYS13N, CYS145N, CYS149N, CYS16N, CYS19N, CYS209N, CYS23N, CYS318M, CYS330M, CYS808M, GLN14N, GLN206N, GLN236M, GLN338M, GLN40N, GLN804M, GLN810M, GLU210M, GLU211N, GLU220M, GLU230M, GLU234N, GLU26N, GLU28N, GLU319M, GLU31N, GLU322M, GLU331M, GLU3M, GLU49N, GLU52N, GLU763M, GLU807M, GLY13M, GLY150N, GLY202N, GLY207N, GLY228M, GLY22N, GLY233N, GLY326M, GLY42N, GLY54N, GLY65M, GLY749M, HIS131N, HIS147N, HIS251M, HIS254M, HIS27N, HIS43N, HIS760M, ILE203N, ILE212M, ILE233M, ILE248M, ILE25M, ILE26M, ILE332M, ILE48N, ILE59M, ILE61N, ILE70M, ILE757M, ILE771M, ILE777M, LEU132N, LEU204N, LEU258M, LEU29N, LEU335M, LEU74M, LEU809M, LYS12N, LYS21M, LYS236N, LYS239M, LYS24M, LYS262M, LYS267M, LYS273N, LYS341M, LYS342M, LYS56M, LYS67M, LYS750M, LYS758M, LYS768M, MET142N, MET211M, MET21N, MET24N, MET252M, MET28M, MET31M, MET39N, MET46N, MET69M, MET754M, PHE152N, PHE17M, PHE194N, PHE20N, PHE210N, PHE229M, PHE231N, PHE232N, PHE245M, PHE247M, PHE264M, PHE271N, PHE33M, PHE66M, PHE741M, PRO140N, PRO219M, PRO250M, PRO266M, PRO30M, PRO328M, PRO33N, PRO53M, PRO54M, PRO57N, PRO61M, PRO65N, PRO811M, SER137N, SER151N, SER231M, SER265M, SER325M, SER38N, SER58M, SER68M, SER72M, SER752M, SER776M, THR221M, THR255M, THR29M, THR55N, THR57M, THR63M, THR66N, THR806M, THR813M, TRP138N, TRP237M, TRP263M, TRP32N, TRP339M, TYR115N, TYR198N, TYR19M, TYR56N, TYR62M, TYR63N, TYR71M, TYR753M, TYR756M, VAL10N, VAL153N, VAL16M, VAL18M, VAL205N, VAL213M, VAL246M, VAL259M, VAL327M, VAL4M, VAL762M, VAL805M
• M-Q: GLU291M, GLU291Q, LYS290M, LYS290Q
• M-R: ALA251R, ALA46M, ARG47M, ASP250R, ASP252R, GLY253R, GLY48M, LYS214R, LYS254R, LYS49M, PHE210R, THR50M, VAL205R
• M-S: ALA321M, ALA329M, ALA506S, ALA727M, ALA727S, ARG333M, ARG337M, ARG509S, ARG796S, ARG846S, ASP305M, ASP312M, ASP705S, ASP795S, ASP845S, CYS318M, CYS330M, CYS455S, GLN462S, GLN701S, GLN721M, GLU285M, GLU319M, GLU322M, GLU323M, GLU324M, GLU454S, GLU699S, GLU700S, GLU706M, GLU706S, GLU719S, GLY309M, GLY313M, GLY326M, GLY458S, GLY459S, GLY702S, GLY797S, HIS516S, HIS707S, HIS723M, HIS723S, ILE332M, ILE456S, ILE704M, ILE704S, ILE874S, LEU308M, LEU450S, LEU726M, LEU726S, LEU861S, LYS284M, LYS310M, LYS451S, LYS460S, LYS512S, LYS722M, LYS729M, LYS729S, LYS831S, LYS850S, MET457S, MET513S, PHE461S, PRO315M, PRO328M, PRO453S, PRO709M, PRO716M, PRO725M, PRO725S, SER724M, SER724S, THR281M, THR311M, THR314M, THR317M, TRP320M, TRP718S, TYR280M, TYR306M, TYR703S, TYR730S, TYR847S, TYR851S, TYR875S, VAL327M, VAL728M, VAL728S
• M-U: ARG648M, ARG655M, ARG661M, ARG782U, ASN645M, ASN647M, ASN786U, ASP664M, ASP765U, ASP788U, ASP868U, ASP870U, GLN103U, GLU203M, GLU398M, GLU45M, GLU659M, GLU662M, GLU873U, GLY660M, GLY783U, GLY787U, GLY869U, ILE784U, LEU789U, LEU826U, LYS102U, LYS207M, LYS43M, LYS649M, LYS650M, LYS679M, LYS785U, LYS866U, LYS871U, PRO646M, THR651M, TRP656M, TRP867U, TYR872U, VAL652M, VAL764U
• N-Q: ALA251N, ALA46Q, ARG47Q, ASP240Q, ASP250N, ASP252N, GLN206N, GLY253N, GLY48Q, LYS214N, LYS254N, LYS49Q, PHE210N, THR50Q, VAL205N
• N-S: ALA727S, ASP208N, CYS209N, GLN206N, GLN721S, GLU863S, GLU865S, GLY207N, LEU204N, LEU274N, LEU726S, LYS273N, LYS722S, LYS729S, PHE271N, PRO725S, PRO731S, SER724S, TYR730S, TYR793S, VAL205N, VAL728S
• O-P: ALA11P, ALA139P, ALA146P, ALA201P, ALA256O, ALA260O, ALA329O, ALA334O, ALA336O, ALA60O, ALA64O, ARG144P, ARG193P, ARG234O, ARG235O, ARG257O, ARG27O, ARG333O, ARG337O, ARG41P, ARG44P, ARG50P, ARG51P, ARG53P, ARG55O, ARG58P, ARG64P, ARG6O, ARG740O, ARG761O, ARG773O, ASN148P, ASN17P, ASN18P, ASN190P, ASN230P, ASN232O, ASN253O, ASN30P, ASN47P, ASN569O, ASN59P, ASN62P, ASN751O, ASN755O, ASN775O, ASN786O, ASP135P, ASP15P, ASP208P, ASP218O, ASP240O, ASP244O, ASP249O, ASP25P, ASP261O, ASP268P, ASP32O, ASP60P, ASP73O, ASP759O, ASP9P, CYS129P, CYS13P, CYS145P, CYS149P, CYS16P, CYS19P, CYS209P, CYS23P, CYS318O, CYS330O, CYS808O, GLN14P, GLN206P, GLN236O, GLN338O, GLN40P, GLN804O, GLN810O, GLU210O, GLU211P, GLU220O, GLU230O, GLU234P, GLU26P, GLU28P, GLU319O, GLU31P, GLU322O, GLU331O, GLU49P, GLU52P, GLU763O, GLU807O, GLY13O, GLY150P, GLY202P, GLY207P, GLY228O, GLY22P, GLY233P, GLY326O, GLY42P, GLY54P, GLY65O, GLY749O, HIS131P, HIS147P, HIS251O, HIS254O, HIS27P, HIS43P, HIS760O, ILE203P, ILE212O, ILE233O, ILE248O, ILE25O, ILE26O, ILE332O, ILE48P, ILE59O, ILE61P, ILE70O, ILE757O, ILE771O, ILE777O, LEU132P, LEU204P, LEU258O, LEU29P, LEU335O, LEU74O, LEU809O, LYS12P, LYS189P, LYS21O, LYS236P, LYS239O, LYS24O, LYS262O, LYS267O, LYS273P, LYS341O, LYS342O, LYS56O, LYS67O, LYS750O, LYS758O, LYS768O, MET142P, MET211O, MET21P, MET24P, MET252O, MET28O, MET31O, MET39P, MET46P, MET69O, MET754O, PHE152P, PHE17O, PHE194P, PHE20P, PHE210P, PHE229O, PHE231P, PHE232P, PHE245O, PHE247O, PHE264O, PHE271P, PHE33O, PHE66O, PHE741O, PRO140P, PRO219O, PRO250O, PRO266O, PRO30O, PRO328O, PRO33P, PRO53O, PRO54O, PRO57P, PRO61O, PRO65P, PRO811O, SER137P, SER151P, SER231O, SER265O, SER325O, SER38P, SER58O, SER68O, SER72O, SER752O, SER776O, THR200P, THR221O, THR255O, THR29O, THR55P, THR57O, THR63O, THR66P, THR806O, TRP138P, TRP237O, TRP263O, TRP32P, TRP339O, TYR115P, TYR198P, TYR19O, TYR56P, TYR62O, TYR63P, TYR71O, TYR753O, TYR756O, VAL10P, VAL153P, VAL16O, VAL205P, VAL213O, VAL246O, VAL259O, VAL327O, VAL4O, VAL762O, VAL805O
• P-S: ALA74P, ALA78P, ARG648S, ARG678S, ASN645S, ASN647S, ASN73P, ASP396S, ASP632S, ASP644S, CYS71P, CYS76P, GLN3P, GLN86P, GLU169P, GLU179P, GLU398S, GLU45S, GLU633S, GLU662S, GLU72P, GLU88P, GLY181P, LEU180P, LYS177P, LYS183P, LYS207S, LYS222P, LYS627S, LYS649S, LYS650S, LYS79P, MET1P, PRO110P, PRO178P, PRO643S, PRO646S, PRO75P, THR108P, THR182P, THR630S, THR651S, TYR111P, TYR628S, VAL77P
• Q-R: ALA11R, ALA139R, ALA146R, ALA201R, ALA256Q, ALA260Q, ALA329Q, ALA334Q, ALA336Q, ALA60Q, ALA64Q, ARG144R, ARG193R, ARG234Q, ARG235Q, ARG257Q, ARG27Q, ARG333Q, ARG337Q, ARG41R, ARG44R, ARG50R, ARG53R, ARG55Q, ARG58R, ARG64R, ARG6Q, ARG740Q, ARG761Q, ARG773Q, ASN148R, ASN17R, ASN18R, ASN230R, ASN232Q, ASN253Q, ASN30R, ASN47R, ASN569Q, ASN59R, ASN62R, ASN751Q, ASN755Q, ASN775Q, ASN786Q, ASP135R, ASP15R, ASP208R, ASP218Q, ASP240Q, ASP244Q, ASP249Q, ASP25R, ASP261Q, ASP268R, ASP32Q, ASP60R, ASP73Q, ASP759Q, ASP9R, CYS129R, CYS13R, CYS145R, CYS149R, CYS16R, CYS19R, CYS209R, CYS23R, CYS318Q, CYS330Q, CYS808Q, GLN14R, GLN206R, GLN236Q, GLN338Q, GLN40R, GLN804Q, GLN810Q, GLU210Q, GLU211R, GLU220Q, GLU230Q, GLU234R, GLU26R, GLU28R, GLU319Q, GLU31R, GLU322Q, GLU331Q, GLU49R, GLU52R, GLU763Q, GLU807Q, GLY13Q, GLY150R, GLY202R, GLY207R, GLY228Q, GLY22R, GLY233R, GLY326Q, GLY42R, GLY54R, GLY65Q, GLY749Q, HIS131R, HIS147R, HIS251Q, HIS254Q, HIS27R, HIS43R, HIS760Q, ILE203R, ILE212Q, ILE233Q, ILE248Q, ILE25Q, ILE26Q, ILE332Q, ILE48R, ILE59Q, ILE61R, ILE70Q, ILE757Q, ILE771Q, ILE777Q, LEU132R, LEU204R, LEU258Q, LEU29R, LEU335Q, LEU74Q, LEU809Q, LYS12R, LYS21Q, LYS236R, LYS239Q, LYS24Q, LYS262Q, LYS267Q, LYS273R, LYS341Q, LYS342Q, LYS56Q, LYS67Q, LYS750Q, LYS758Q, LYS768Q, MET142R, MET211Q, MET21R, MET24R, MET252Q, MET28Q, MET31Q, MET39R, MET46R, MET69Q, MET754Q, PHE152R, PHE17Q, PHE194R, PHE20R, PHE210R, PHE229Q, PHE231R, PHE232R, PHE245Q, PHE247Q, PHE264Q, PHE271R, PHE33Q, PHE66Q, PHE741Q, PRO140R, PRO219Q, PRO250Q, PRO266Q, PRO30Q, PRO328Q, PRO53Q, PRO54Q, PRO57R, PRO61Q, PRO65R, PRO811Q, SER137R, SER151R, SER231Q, SER265Q, SER325Q, SER38R, SER58Q, SER68Q, SER72Q, SER752Q, SER776Q, THR221Q, THR255Q, THR29Q, THR55R, THR57Q, THR63Q, THR66R, THR806Q, THR813Q, TRP138R, TRP237Q, TRP263Q, TRP32R, TRP339Q, TYR115R, TYR198R, TYR19Q, TYR56R, TYR62Q, TYR63R, TYR71Q, TYR753Q, TYR756Q, VAL10R, VAL153R, VAL16Q, VAL205R, VAL213Q, VAL246Q, VAL259Q, VAL327Q, VAL4Q, VAL762Q, VAL805Q
• Q-S: ALA781S, ARG648Q, ARG655Q, ARG661Q, ARG678Q, ARG782S, ASN645Q, ASN647Q, ASN786S, ASP200Q, ASP664Q, ASP765S, ASP788S, ASP868S, ASP870S, GLN103S, GLU203Q, GLU398Q, GLU45Q, GLU659Q, GLU662Q, GLU865S, GLU873S, GLY660Q, GLY783S, GLY787S, GLY827S, GLY869S, ILE784S, LEU789S, LEU826S, LYS102S, LYS207Q, LYS43Q, LYS649Q, LYS650Q, LYS679Q, LYS785S, LYS866S, LYS871S, PRO382Q, PRO40Q, PRO646Q, THR651Q, TRP656Q, TRP867S, TYR872S, VAL652Q, VAL764S
• Q-U: ALA321Q, ALA329Q, ALA506U, ALA727Q, ALA727U, ARG333Q, ARG337Q, ARG509U, ARG796U, ARG846U, ASP305Q, ASP312Q, ASP705U, ASP795U, ASP845U, CYS318Q, CYS330Q, CYS455U, GLN462U, GLN701U, GLN721Q, GLU285Q, GLU302Q, GLU319Q, GLU322Q, GLU323Q, GLU324Q, GLU454U, GLU699U, GLU700U, GLU706Q, GLU706U, GLY309Q, GLY313Q, GLY326Q, GLY458U, GLY459U, GLY702U, GLY797U, GLY830U, HIS516U, HIS707U, HIS723Q, HIS723U, ILE332Q, ILE456U, ILE704Q, ILE704U, ILE874U, LEU308Q, LEU450U, LEU726Q, LEU726U, LEU861U, LYS284Q, LYS310Q, LYS451U, LYS460U, LYS512U, LYS722Q, LYS729Q, LYS729U, LYS831U, LYS850U, MET457U, MET513U, PHE461U, PRO315Q, PRO328Q, PRO453U, PRO709Q, PRO716Q, PRO725Q, PRO725U, SER724Q, SER724U, THR281Q, THR311Q, THR314Q, THR317Q, TRP320Q, TRP718U, TYR280Q, TYR306Q, TYR703U, TYR730U, TYR847U, TYR851U, TYR875U, VAL327Q, VAL728Q, VAL728U
• R-U: ALA727U, ASP208R, CYS209R, GLN206R, GLN721U, GLU863U, GLU865U, GLY207R, LEU204R, LEU274R, LEU726U, LYS273R, LYS722U, LYS729U, PHE271R, PRO725U, PRO731U, SER724U, TYR730U, TYR793U, VAL205R, VAL728U
• S-T: ALA11T, ALA139T, ALA146T, ALA201T, ALA256S, ALA260S, ALA329S, ALA334S, ALA336S, ALA60S, ALA64S, ARG144T, ARG193T, ARG234S, ARG235S, ARG257S, ARG27S, ARG333S, ARG337S, ARG41T, ARG44T, ARG50T, ARG51T, ARG53T, ARG55S, ARG58T, ARG64T, ARG6S, ARG740S, ARG761S, ARG773S, ASN148T, ASN17T, ASN18T, ASN190T, ASN230T, ASN232S, ASN253S, ASN30T, ASN47T, ASN569S, ASN59T, ASN62T, ASN751S, ASN755S, ASN775S, ASN786S, ASP135T, ASP15T, ASP208T, ASP218S, ASP240S, ASP244S, ASP249S, ASP25T, ASP261S, ASP268T, ASP32S, ASP60T, ASP73S, ASP759S, ASP9T, CYS129T, CYS13T, CYS145T, CYS149T, CYS16T, CYS19T, CYS209T, CYS23T, CYS318S, CYS330S, CYS808S, GLN14T, GLN206T, GLN236S, GLN338S, GLN40T, GLN804S, GLN810S, GLU210S, GLU211T, GLU220S, GLU230S, GLU234T, GLU26T, GLU28T, GLU319S, GLU31T, GLU322S, GLU331S, GLU49T, GLU52T, GLU763S, GLU807S, GLY13S, GLY150T, GLY202T, GLY207T, GLY228S, GLY22T, GLY233T, GLY326S, GLY42T, GLY54T, GLY65S, HIS131T, HIS147T, HIS251S, HIS254S, HIS27T, HIS43T, HIS760S, ILE203T, ILE212S, ILE233S, ILE248S, ILE25S, ILE26S, ILE332S, ILE48T, ILE59S, ILE61T, ILE70S, ILE757S, ILE771S, ILE777S, LEU132T, LEU204T, LEU258S, LEU29T, LEU335S, LEU809S, LYS12T, LYS21S, LYS236T, LYS239S, LYS24S, LYS262S, LYS267S, LYS273T, LYS341S, LYS342S, LYS56S, LYS67S, LYS750S, LYS758S, LYS768S, MET142T, MET211S, MET21T, MET24T, MET252S, MET28S, MET31S, MET39T, MET46T, MET69S, MET754S, PHE152T, PHE17S, PHE194T, PHE20T, PHE210T, PHE229S, PHE231T, PHE232T, PHE245S, PHE247S, PHE264S, PHE271T, PHE33S, PHE66S, PHE741S, PRO140T, PRO219S, PRO250S, PRO266S, PRO30S, PRO328S, PRO33T, PRO53S, PRO54S, PRO57T, PRO61S, PRO65T, PRO811S, SER137T, SER151T, SER231S, SER265S, SER325S, SER38T, SER58S, SER68S, SER72S, SER752S, SER776S, THR221S, THR255S, THR29S, THR55T, THR57S, THR63S, THR66T, THR806S, TRP138T, TRP237S, TRP263S, TRP32T, TRP339S, TYR115T, TYR198T, TYR19S, TYR56T, TYR62S, TYR63T, TYR71S, TYR753S, TYR756S, TYR817S, VAL10T, VAL153T, VAL16S, VAL205T, VAL213S, VAL246S, VAL259S, VAL327S, VAL4S, VAL762S, VAL805S
• U-V: ALA11V, ALA139V, ALA146V, ALA201V, ALA256U, ALA260U, ALA329U, ALA334U, ALA336U, ALA60U, ALA64U, ARG144V, ARG193V, ARG234U, ARG235U, ARG257U, ARG27U, ARG333U, ARG337U, ARG41V, ARG44V, ARG50V, ARG53V, ARG55U, ARG58V, ARG64V, ARG6U, ARG740U, ARG761U, ARG773U, ASN148V, ASN17V, ASN18V, ASN190V, ASN230V, ASN232U, ASN253U, ASN30V, ASN47V, ASN569U, ASN59V, ASN62V, ASN751U, ASN755U, ASN775U, ASN786U, ASP135V, ASP15V, ASP208V, ASP218U, ASP240U, ASP244U, ASP249U, ASP25V, ASP261U, ASP268V, ASP32U, ASP60V, ASP73U, ASP759U, ASP9V, CYS129V, CYS13V, CYS145V, CYS149V, CYS16V, CYS19V, CYS209V, CYS23V, CYS318U, CYS330U, CYS808U, GLN14V, GLN206V, GLN236U, GLN338U, GLN40V, GLN804U, GLN810U, GLU210U, GLU211V, GLU220U, GLU230U, GLU234V, GLU26V, GLU28V, GLU319U, GLU31V, GLU322U, GLU331U, GLU3U, GLU49V, GLU52V, GLU763U, GLU807U, GLY13U, GLY150V, GLY202V, GLY207V, GLY228U, GLY22V, GLY233V, GLY326U, GLY42V, GLY54V, GLY65U, GLY749U, HIS131V, HIS147V, HIS251U, HIS254U, HIS27V, HIS43V, HIS760U, ILE203V, ILE212U, ILE233U, ILE248U, ILE25U, ILE26U, ILE332U, ILE48V, ILE59U, ILE61V, ILE70U, ILE757U, ILE771U, ILE777U, LEU132V, LEU204V, LEU258U, LEU29V, LEU335U, LEU74U, LEU809U, LYS12V, LYS21U, LYS236V, LYS239U, LYS24U, LYS262U, LYS267U, LYS273V, LYS341U, LYS342U, LYS56U, LYS67U, LYS750U, LYS758U, LYS768U, MET142V, MET211U, MET21V, MET24V, MET252U, MET28U, MET31U, MET39V, MET46V, MET69U, MET754U, PHE152V, PHE17U, PHE194V, PHE20V, PHE210V, PHE229U, PHE231V, PHE232V, PHE245U, PHE247U, PHE264U, PHE271V, PHE66U, PHE741U, PRO140V, PRO219U, PRO250U, PRO266U, PRO30U, PRO328U, PRO33V, PRO53U, PRO54U, PRO57V, PRO61U, PRO65V, PRO811U, SER137V, SER151V, SER231U, SER265U, SER325U, SER38V, SER58U, SER68U, SER72U, SER752U, SER776U, THR200V, THR221U, THR255U, THR29U, THR55V, THR57U, THR63U, THR66V, THR806U, THR813U, TRP138V, TRP237U, TRP263U, TRP32V, TRP339U, TYR115V, TYR198V, TYR19U, TYR56V, TYR62U, TYR63V, TYR71U, TYR753U, TYR756U, VAL10V, VAL153V, VAL16U, VAL205V, VAL213U, VAL246U, VAL259U, VAL327U, VAL4U, VAL762U, VAL805U
• V-X: ALA78X, LYS214V
• W-X: ARG144X, ARG257W, ARG27W, ARG333W, ARG337W, ARG44X, ARG50X, ARG58X, ARG740W, ASN18X, ASN30X, ASN47X, ASP15X, ASP208X, ASP25X, ASP261W, ASP268X, ASP32W, ASP759W, GLN14X, GLU211X, GLU234X, GLU26X, GLU28X, GLU331W, GLU49X, GLU52X, GLU807W, HIS147X, HIS254W, HIS27X, ILE26W, ILE48X, ILE59W, LEU29X, LYS24W, LYS262W, LYS56W, LYS67W, LYS758W, MET28W, TYR56X