1VDM

crystal structure of purine phosphoribosyltransferase from pyrococcus horikoshii ot3

• Total interactions analyzed: 66
• Total true interactions: 33
• Strongest Interaction:
  • Chains: H-K
  • Int. Res.: 34
  • Norm. En. per Res.: -4.8009
• Hub Node: B(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-13.454	-78.6401	-238.436	-330.5301	98	7	12	11238	4	29	31
A-C	-24.7867	-30.5975	-200.173	-255.5572	66	5	8	7824	0	15	15
A-D	-13.099	-33.9238	-84.1692	-131.1919	33	8	1	2925	9	15	17
A-E	-22.4419	-28.7723	-207.896	-259.1101	68	5	9	7984	1	17	17
B-D	-31.1962	-32.2254	-239.768	-303.1896	74	5	8	9021	2	18	18
B-E	-5.7535	-76.6501	-83.3868	-165.7903	38	7	1	3234	8	16	18
B-F	-37.4927	-10.2289	-245.126	-292.8476	74	6	8	9191	1	16	18
B-H	-32.6954	-71.0667	-154.137	-257.8992	72	3	0	5806	5	36	37
B-J	0.0	0.0	-5.5694	-5.5694	8	5	0	383	0	2	4
B-L	0.0	10.0853	-0.8157	9.2696	10	0	0	143	0	8	7
C-D	-19.9312	-66.0938	-251.38	-337.405	102	4	10	11296	3	27	31
C-E	-14.5853	-9.5505	-192.205	-216.3408	69	4	9	7963	0	16	16
C-F	0.0	-60.5687	-80.3397	-140.9084	35	3	1	2890	7	16	17
D-F	-34.02	-22.0612	-233.357	-289.4382	74	7	8	9027	1	16	17
D-H	0.0	0.0	-5.5471	-5.5471	8	4	0	350	0	2	4
D-J	0.0	13.379	-0.2946	13.0845	6	0	0	32	0	6	4
D-L	-36.9081	-33.2242	-103.156	-173.2883	60	10	0	4603	3	29	30
E-F	0.0	-58.5812	-242.292	-300.8732	100	5	11	11380	2	27	32
F-H	0.0	15.1159	-0.6377	14.4781	7	0	0	69	0	7	5
F-J	-40.2626	-24.8746	-122.186	-187.3232	60	4	0	5101	4	37	37
F-L	0.0	0.0	-11.4941	-11.4941	8	2	0	325	0	3	4
G-H	-8.4163	-61.8468	-245.479	-315.7421	101	7	11	11487	5	27	32
G-I	-20.8668	-28.5833	-196.018	-245.4681	70	6	8	7806	1	15	15
G-J	-5.7364	-57.6294	-78.2782	-141.644	34	5	1	2789	5	15	16
G-K	-31.4183	-23.3921	-206.739	-261.5494	72	10	9	8040	0	14	15
H-J	-43.9546	-18.724	-230.348	-293.0266	71	5	8	8902	1	18	20
H-K	-6.2455	-69.3417	-87.6446	-163.2317	34	6	1	2964	7	15	18
H-L	-30.1572	-14.7057	-237.596	-282.4588	75	6	8	9177	1	17	20
I-J	-13.4951	-66.6525	-233.542	-313.6896	98	6	11	11024	3	28	31
I-K	-14.8566	-4.9561	-200.248	-220.0607	69	6	9	7811	0	14	15
I-L	0.0	-65.2315	-88.3587	-153.5902	35	4	1	3176	6	16	18
J-L	-25.9413	-3.4934	-231.149	-260.5838	71	5	8	9023	1	16	17
K-L	-7.6919	-74.2386	-242.588	-324.5185	98	8	10	11006	3	27	34

Interface residues

• A-B: ALA34A, ALA34B, ALA41A, ALA41B, ARG23A, ARG23B, ARG35A, ARG35B, ARG43A, ARG43B, ARG67A, ASP12A, ASP12B, ASP50A, ASP50B, ASP57A, ASP57B, ASP91B, GLU145A, GLU145B, GLU146A, GLU146B, GLY32A, GLY32B, GLY36A, GLY36B, GLY37A, GLY37B, GLY49A, GLY79A, HIS46A, HIS46B, HIS78A, HIS78B, ILE15A, ILE15B, ILE30A, ILE30B, ILE31A, ILE39A, ILE39B, ILE47A, ILE47B, ILE51A, ILE51B, ILE56A, ILE56B, ILE75A, ILE75B, ILE77A, ILE77B, LEU38A, LEU38B, LEU44A, LEU44B, LEU48A, LEU48B, LEU53A, LEU53B, LYS54A, LYS54B, LYS59A, LYS59B, PHE142B, PHE147A, PHE147B, PHE16A, PHE16B, PRO143A, PRO143B, PRO148A, PRO40A, PRO40B, PRO52A, PRO52B, PRO76A, PRO76B, SER45A, SER45B, THR74A, THR74B, THR7B, TRP144A, TRP144B, TRP8A, TRP8B, TRP9A, TRP9B, TYR61A, TYR61B, VAL11A, VAL11B, VAL29A, VAL33A, VAL42A, VAL42B, VAL55A, VAL55B
• A-C: ALA117A, ALA120A, ALA14A, ALA17A, ALA19A, ARG135A, ARG13A, ASP12A, ASP130A, ASP2C, CYS118A, GLN10A, GLN10C, GLU137A, GLU145C, GLU146C, GLU151C, GLU20A, GLU24A, ILE103A, ILE116A, ILE140A, ILE150C, ILE15A, LEU119A, LEU18A, LEU22A, LEU6A, LEU6C, LYS115A, LYS138A, LYS138C, LYS152C, LYS21A, LYS3C, MET121A, MET1C, PHE134A, PHE142C, PHE147C, PHE16A, PRO123A, PRO129A, PRO143C, PRO148C, SER126A, THR136A, THR7A, THR7C, TRP144C, TRP8A, TRP8C, TRP9A, TRP9C, TYR131A, TYR132A, TYR5A, TYR5C, VAL11A, VAL127A, VAL128A, VAL133A, VAL141C, VAL149C, VAL4A, VAL4C
• A-D: ALA14A, ALA14D, ALA17A, ALA17D, ALA19A, ALA19D, ARG13A, ARG13D, ARG23A, ARG23D, ARG43A, ARG43D, ASP12A, ASP12D, GLN10A, GLU20A, GLU20D, GLY49A, HIS46A, ILE15A, ILE15D, ILE47A, ILE47D, LEU48A, LEU48D, LYS21D, PHE16A, PHE16D, TRP8A, TRP8D, TRP9A, TRP9D, VAL11D
• A-E: ALA117E, ALA120E, ALA14E, ALA17E, ALA19E, ARG135E, ARG13E, ASP12E, ASP130E, ASP2A, CYS118E, GLN10A, GLN10E, GLU137E, GLU145A, GLU146A, GLU151A, GLU153A, GLU20E, GLU24E, ILE103E, ILE114E, ILE116E, ILE140E, ILE150A, ILE15E, LEU119E, LEU18E, LEU22E, LEU6A, LEU6E, LYS115E, LYS138A, LYS138E, LYS152A, LYS21E, LYS3A, MET121E, MET1A, PHE134E, PHE142A, PHE147A, PHE16E, PRO123E, PRO129E, PRO143A, PRO148A, SER126E, THR136E, THR7A, THR7E, TRP144A, TRP8A, TRP8E, TRP9A, TRP9E, TYR131E, TYR132E, TYR5A, TYR5E, VAL11E, VAL127E, VAL128E, VAL133E, VAL141A, VAL149A, VAL4A, VAL4E
• B-D: ALA117D, ALA120D, ALA14D, ALA17D, ALA19D, ARG135D, ARG13D, ASP12D, ASP130D, ASP2B, CYS118D, GLN10B, GLN10D, GLU137D, GLU145B, GLU146B, GLU151B, GLU153B, GLU20D, GLU24D, ILE103D, ILE114D, ILE116D, ILE140D, ILE150B, ILE15D, LEU119D, LEU18D, LEU22D, LEU6B, LEU6D, LYS115D, LYS122D, LYS138B, LYS138D, LYS152B, LYS21D, LYS3B, MET121D, MET1B, MET1D, PHE134D, PHE142B, PHE142D, PHE147B, PHE16D, PRO123D, PRO129D, PRO143B, PRO148B, SER126D, THR136D, THR7B, THR7D, TRP139D, TRP144B, TRP8B, TRP9B, TRP9D, TYR131D, TYR132D, TYR25D, TYR5B, TYR5D, VAL11B, VAL11D, VAL127D, VAL128D, VAL133D, VAL141B, VAL141D, VAL149B, VAL4B, VAL4D
• B-E: ALA14B, ALA14E, ALA17B, ALA17E, ALA19B, ALA19E, ARG13B, ARG13E, ARG23B, ARG23E, ARG43B, ARG43E, ASP12B, ASP12E, GLN10E, GLU20B, GLU20E, GLY49E, HIS46B, HIS46E, ILE15B, ILE15E, ILE47B, ILE47E, LEU18B, LEU44B, LEU48B, LEU48E, LYS21B, LYS21E, PHE16B, PHE16E, TRP8B, TRP8E, TRP9B, TRP9E, VAL11B, VAL11E
• B-F: ALA117B, ALA120B, ALA14B, ALA17B, ALA19B, ARG135B, ARG13B, ASP12B, ASP130B, ASP2F, CYS118B, GLN10B, GLN10F, GLU137B, GLU145F, GLU146F, GLU151F, GLU20B, GLU24B, ILE103B, ILE114B, ILE116B, ILE140B, ILE150F, ILE15B, LEU119B, LEU18B, LEU22B, LEU6B, LEU6F, LYS115B, LYS122B, LYS138B, LYS138F, LYS152F, LYS21B, LYS3F, MET121B, MET1F, PHE134B, PHE142B, PHE142F, PHE147F, PHE16B, PRO123B, PRO129B, PRO143F, PRO148F, SER126B, THR125B, THR136B, THR7B, THR7F, TRP139B, TRP144F, TRP8F, TRP9B, TRP9F, TYR131B, TYR132B, TYR25B, TYR5B, TYR5F, VAL11B, VAL11F, VAL127B, VAL128B, VAL133B, VAL141B, VAL141F, VAL149F, VAL4B, VAL4F, VAL92B
• B-H: ARG135B, ARG135H, ARG67H, ASP2B, ASP2H, ASP94B, ASP94H, GLU100B, GLU100H, GLU104B, GLU105B, GLU137B, GLU137H, GLU153B, GLU153H, GLU69B, GLU69H, GLY63B, GLY68B, GLY68H, GLY96H, ILE103B, ILE140B, ILE140H, ILE150B, ILE150H, ILE56B, ILE73B, LYS107B, LYS108B, LYS122B, LYS122H, LYS138B, LYS138H, LYS3B, LYS3H, LYS62B, LYS62H, LYS70B, LYS70H, LYS97B, LYS97H, MET1B, MET1H, PHE60B, PHE60H, PRO123B, PRO123H, PRO71B, PRO71H, SER126H, THR125B, THR125H, THR136B, THR136H, THR95B, THR95H, TRP124B, TRP124H, TRP139B, TRP139H, TYR61H, VAL101B, VAL101H, VAL102B, VAL106B, VAL128B, VAL128H, VAL4B, VAL4H, VAL58B, VAL72B
• B-J: ARG135B, ARG135J, MET121B, MET121J, PRO123B, PRO123J, TYR132B, TYR132J
• B-L: ASP2B, ASP2L, GLU153B, GLU153L, LYS138B, LYS138L, LYS152B, LYS152L, MET1B, MET1L
• C-D: ALA19C, ALA34C, ALA34D, ALA41C, ALA41D, ARG23C, ARG23D, ARG35C, ARG35D, ARG43C, ARG43D, ASP12C, ASP12D, ASP50C, ASP50D, ASP57C, ASP57D, ASP91D, GLU145C, GLU145D, GLU146C, GLU146D, GLY32C, GLY32D, GLY36C, GLY36D, GLY37C, GLY37D, GLY49C, GLY49D, GLY79D, HIS46C, HIS46D, HIS78C, HIS78D, ILE15C, ILE15D, ILE30C, ILE30D, ILE31D, ILE39C, ILE39D, ILE47C, ILE47D, ILE51C, ILE51D, ILE56C, ILE56D, ILE73C, ILE75C, ILE75D, ILE77C, ILE77D, LEU38C, LEU38D, LEU44C, LEU44D, LEU48C, LEU48D, LEU53C, LEU53D, LYS54C, LYS54D, LYS59C, LYS59D, PHE142D, PHE147C, PHE147D, PHE16C, PHE16D, PRO143C, PRO143D, PRO148C, PRO40C, PRO40D, PRO52C, PRO52D, PRO76C, PRO76D, SER45C, SER45D, THR74C, THR74D, THR7C, THR7D, TRP144C, TRP144D, TRP8C, TRP8D, TRP9C, TRP9D, TYR61D, VAL11C, VAL11D, VAL141D, VAL29C, VAL29D, VAL33C, VAL42C, VAL42D, VAL55C, VAL55D
• C-E: ALA117C, ALA120C, ALA14C, ALA17C, ALA19C, ARG135C, ARG13C, ASP12C, ASP130C, ASP2E, CYS118C, GLN10C, GLN10E, GLU137C, GLU145E, GLU146E, GLU151E, GLU153E, GLU20C, GLU24C, ILE116C, ILE140C, ILE150E, ILE15C, LEU119C, LEU18C, LEU22C, LEU6C, LEU6E, LYS115C, LYS122C, LYS138C, LYS138E, LYS152E, LYS21C, LYS3C, LYS3E, MET121C, MET1E, PHE134C, PHE142C, PHE142E, PHE147E, PHE16C, PRO129C, PRO143E, PRO148E, THR136C, THR7C, THR7E, TRP139C, TRP144E, TRP8C, TRP8E, TRP9C, TRP9E, TYR131C, TYR132C, TYR5C, TYR5E, VAL11C, VAL127C, VAL128C, VAL133C, VAL141C, VAL141E, VAL149E, VAL4C, VAL4E
• C-F: ALA14C, ALA14F, ALA17C, ALA17F, ALA19C, ALA19F, ARG13C, ARG13F, ARG23C, ARG23F, ARG43C, ARG43F, ASP12C, ASP12F, GLN10C, GLU20C, GLU20F, GLY49C, GLY49F, HIS46C, ILE15C, ILE15F, ILE47C, ILE47F, LEU48C, LEU48F, LYS21C, LYS21F, PHE16C, PHE16F, TRP8C, TRP8F, TRP9C, TRP9F, VAL11F
• D-F: ALA117F, ALA120F, ALA14F, ALA17F, ALA19F, ARG135F, ARG13F, ARG23F, ASP12F, ASP130F, ASP2D, CYS118F, GLN10D, GLN10F, GLU137F, GLU145D, GLU146D, GLU151D, GLU20F, GLU24F, ILE103F, ILE114F, ILE116F, ILE140F, ILE150D, ILE15F, LEU119F, LEU18F, LEU22F, LEU6D, LEU6F, LYS115F, LYS122F, LYS138D, LYS138F, LYS152D, LYS21F, LYS3D, MET121F, MET1D, MET1F, PHE134F, PHE142D, PHE142F, PHE147D, PHE16F, PRO123F, PRO129F, PRO143D, PRO148D, SER126F, THR136F, THR7D, THR7F, TRP139F, TRP144D, TRP8D, TRP9D, TRP9F, TYR131F, TYR132F, TYR25F, TYR5D, TYR5F, VAL11D, VAL11F, VAL127F, VAL128F, VAL133F, VAL141D, VAL141F, VAL149D, VAL4D, VAL4F
• D-H: ARG135D, ARG135H, MET121D, MET121H, PRO123D, PRO123H, TYR132D, TYR132H
• D-J: ASP2D, ASP2J, LYS138D, LYS138J, MET1D, MET1J
• D-L: ARG135D, ARG135L, ASP2D, ASP2L, ASP94D, ASP94L, GLU100D, GLU100L, GLU104L, GLU137D, GLU137L, GLU153L, GLU69D, GLU69L, GLY63L, GLY68D, GLY68L, GLY96L, ILE140D, ILE140L, ILE150D, ILE150L, LYS122D, LYS122L, LYS138D, LYS138L, LYS3D, LYS3L, LYS62D, LYS62L, LYS70D, LYS70L, LYS97D, LYS97L, MET1D, MET1L, PHE60D, PHE60L, PRO123D, PRO123L, PRO71D, PRO71L, SER126L, THR125D, THR125L, THR136D, THR136L, THR95D, THR95L, TRP124D, TRP124L, TRP139D, TRP139L, TYR61D, TYR61L, VAL101D, VAL101L, VAL128D, VAL4D, VAL4L
• E-F: ALA34E, ALA34F, ALA41E, ALA41F, ARG23E, ARG23F, ARG35E, ARG35F, ARG43E, ARG43F, ASP12E, ASP12F, ASP50E, ASP50F, ASP57E, ASP57F, ASP91F, GLU145E, GLU145F, GLU146E, GLU146F, GLY32E, GLY32F, GLY36E, GLY36F, GLY37E, GLY37F, GLY49E, GLY79E, HIS46E, HIS46F, HIS78E, HIS78F, ILE15E, ILE15F, ILE30E, ILE30F, ILE31F, ILE39E, ILE39F, ILE47E, ILE47F, ILE51E, ILE51F, ILE56E, ILE56F, ILE73E, ILE73F, ILE75E, ILE75F, ILE77E, ILE77F, LEU38E, LEU38F, LEU44E, LEU44F, LEU48E, LEU48F, LEU53E, LEU53F, LYS54E, LYS54F, LYS59E, LYS59F, PHE142F, PHE147E, PHE147F, PHE16E, PHE16F, PRO143E, PRO143F, PRO148E, PRO40E, PRO40F, PRO52E, PRO52F, PRO76E, PRO76F, SER45E, SER45F, THR74E, THR74F, THR7F, TRP139E, TRP144E, TRP144F, TRP8E, TRP8F, TRP9E, TRP9F, TYR61F, VAL11E, VAL11F, VAL29F, VAL33F, VAL42E, VAL42F, VAL55E, VAL55F, VAL72F
• F-H: ASP2F, ASP2H, GLU153H, LYS138F, LYS138H, LYS152F, MET1H
• F-J: ARG135F, ARG135J, ARG67J, ASP2F, ASP2J, ASP65F, ASP94F, ASP94J, GLU100J, GLU104J, GLU137F, GLU137J, GLU69F, GLU69J, GLY63F, GLY68F, GLY68J, ILE140F, ILE140J, ILE150F, ILE150J, ILE64F, LYS108J, LYS122F, LYS122J, LYS138F, LYS138J, LYS3F, LYS3J, LYS62F, LYS70F, LYS70J, LYS97F, LYS97J, MET1F, MET1J, PHE60F, PHE60J, PRO123F, PRO123J, PRO71F, PRO71J, SER126J, THR125F, THR125J, THR136F, THR136J, THR95F, THR95J, TRP124F, TRP124J, TRP139F, TRP139J, TYR61F, TYR61J, VAL101F, VAL101J, VAL4F, VAL4J, VAL72F
• F-L: ARG135F, ARG135L, MET121F, MET121L, PRO123F, PRO123L, TYR132F, TYR132L
• G-H: ALA19G, ALA34G, ALA34H, ALA41G, ALA41H, ARG23G, ARG23H, ARG35G, ARG35H, ARG43G, ARG43H, ASP12G, ASP12H, ASP50G, ASP50H, ASP57G, ASP57H, ASP91H, GLU145G, GLU145H, GLU146G, GLU146H, GLY32G, GLY32H, GLY36G, GLY36H, GLY37G, GLY37H, GLY49G, GLY49H, GLY79H, HIS46G, HIS46H, HIS78G, HIS78H, ILE15G, ILE15H, ILE30G, ILE30H, ILE31G, ILE31H, ILE39G, ILE39H, ILE47G, ILE47H, ILE51G, ILE51H, ILE56G, ILE56H, ILE73G, ILE75G, ILE75H, ILE77G, ILE77H, LEU38G, LEU38H, LEU44G, LEU44H, LEU48G, LEU48H, LEU53G, LEU53H, LYS54G, LYS54H, LYS59G, LYS59H, PHE142H, PHE147G, PHE147H, PHE16G, PHE16H, PRO143G, PRO143H, PRO148G, PRO40G, PRO40H, PRO52G, PRO52H, PRO76G, PRO76H, SER45G, SER45H, THR74G, THR74H, THR7H, TRP144G, TRP144H, TRP8G, TRP8H, TRP9G, TRP9H, TYR61H, VAL11G, VAL11H, VAL29H, VAL33G, VAL33H, VAL42G, VAL42H, VAL55G, VAL55H
• G-I: ALA117G, ALA120G, ALA14G, ALA17G, ALA19G, ARG135G, ARG13G, ASP12G, ASP130G, ASP2I, CYS118G, GLN10G, GLN10I, GLU137G, GLU145I, GLU146I, GLU151I, GLU20G, GLU24G, ILE103G, ILE116G, ILE140G, ILE150I, ILE15G, LEU119G, LEU18G, LEU22G, LEU6G, LEU6I, LYS115G, LYS138G, LYS138I, LYS152I, LYS21G, LYS3I, MET121G, MET1I, PHE134G, PHE142G, PHE142I, PHE147I, PHE16G, PRO129G, PRO143I, PRO148I, SER126G, THR136G, THR7G, THR7I, TRP139G, TRP144I, TRP8G, TRP8I, TRP9G, TRP9I, TYR131G, TYR132G, TYR25G, TYR5G, TYR5I, VAL11G, VAL127G, VAL128G, VAL133G, VAL141G, VAL141I, VAL149I, VAL4G, VAL4I, VAL92G
• G-J: ALA14G, ALA14J, ALA17G, ALA17J, ALA19G, ALA19J, ARG13G, ARG13J, ARG23G, ARG23J, ARG43G, ARG43J, ASP12G, ASP12J, GLN10G, GLU20G, GLU20J, GLY49G, HIS46G, ILE15G, ILE15J, ILE47G, ILE47J, LEU48G, LEU48J, LYS21J, PHE16G, PHE16J, TRP8G, TRP8J, TRP9G, TRP9J, VAL11G, VAL11J
• G-K: ALA117K, ALA120K, ALA14K, ALA17K, ALA19K, ARG135K, ARG13K, ASP12K, ASP130K, ASP2G, CYS118K, GLN10G, GLN10K, GLU137K, GLU145G, GLU146G, GLU151G, GLU20K, GLU24K, ILE103K, ILE116K, ILE140K, ILE150G, ILE15K, LEU119K, LEU18K, LEU22K, LEU6G, LEU6K, LYS115K, LYS122K, LYS138G, LYS138K, LYS152G, LYS21K, LYS3G, LYS3K, MET121K, MET1G, PHE134K, PHE142G, PHE147G, PHE16K, PRO123K, PRO129K, PRO143G, PRO148G, SER126K, THR125K, THR136K, THR7G, THR7K, TRP139K, TRP144G, TRP8G, TRP8K, TRP9G, TRP9K, TYR131K, TYR132K, TYR25K, TYR5G, TYR5K, VAL11K, VAL127K, VAL128K, VAL133K, VAL141G, VAL141K, VAL149G, VAL4G, VAL4K
• H-J: ALA117J, ALA120J, ALA14J, ALA17J, ALA19J, ARG135J, ARG13J, ASP12J, ASP130J, ASP2H, CYS118J, GLN10H, GLN10J, GLU137J, GLU145H, GLU146H, GLU151H, GLU153H, GLU20J, GLU24J, ILE103J, ILE114J, ILE116J, ILE140J, ILE150H, ILE15J, LEU119J, LEU18J, LEU22J, LEU6H, LEU6J, LYS115J, LYS138H, LYS138J, LYS152H, LYS21J, LYS3H, MET121J, MET1H, MET1J, PHE134J, PHE142H, PHE147H, PHE16J, PRO123J, PRO129J, PRO143H, PRO148H, SER126J, SER93J, THR136J, THR7H, THR7J, TRP144H, TRP8H, TRP9H, TRP9J, TYR131J, TYR132J, TYR25J, TYR5H, TYR5J, VAL11H, VAL11J, VAL127J, VAL128J, VAL133J, VAL141H, VAL149H, VAL4H, VAL4J
• H-K: ALA14H, ALA14K, ALA17H, ALA17K, ALA19H, ALA19K, ARG13H, ARG13K, ARG23H, ARG23K, ARG43H, ARG43K, ASP12H, ASP12K, GLN10K, GLU20H, GLU20K, GLY49K, HIS46K, ILE15H, ILE15K, ILE47H, ILE47K, LEU48H, LEU48K, LYS21H, PHE16H, PHE16K, TRP8H, TRP8K, TRP9H, TRP9K, VAL11H, VAL11K
• H-L: ALA117H, ALA120H, ALA14H, ALA17H, ALA19H, ARG135H, ARG13H, ASP12H, ASP130H, ASP2L, CYS118H, GLN10H, GLN10L, GLU137H, GLU145L, GLU146L, GLU151L, GLU20H, GLU24H, ILE103H, ILE114H, ILE116H, ILE140H, ILE150L, ILE15H, LEU119H, LEU18H, LEU22H, LEU6H, LEU6L, LYS115H, LYS122H, LYS138H, LYS138L, LYS152L, LYS21H, LYS3H, LYS3L, MET121H, MET1H, MET1L, PHE134H, PHE142H, PHE142L, PHE147L, PHE16H, PRO123H, PRO129H, PRO143L, PRO148L, SER126H, THR136H, THR7H, THR7L, TRP139H, TRP144L, TRP8L, TRP9H, TRP9L, TYR131H, TYR132H, TYR25H, TYR5H, TYR5L, VAL11H, VAL11L, VAL127H, VAL128H, VAL133H, VAL141H, VAL141L, VAL149L, VAL4H, VAL4L, VAL92H
• I-J: ALA34I, ALA34J, ALA41I, ALA41J, ARG23I, ARG23J, ARG35I, ARG35J, ARG43I, ARG43J, ASP12I, ASP12J, ASP50I, ASP50J, ASP57I, ASP57J, ASP91J, GLU145I, GLU145J, GLU146I, GLU146J, GLY32I, GLY32J, GLY36I, GLY36J, GLY37I, GLY37J, GLY49I, GLY49J, GLY79J, HIS46I, HIS46J, HIS78I, HIS78J, ILE15I, ILE15J, ILE30I, ILE30J, ILE31J, ILE39I, ILE39J, ILE47I, ILE47J, ILE51I, ILE51J, ILE56I, ILE56J, ILE73I, ILE75I, ILE75J, ILE77I, ILE77J, LEU38I, LEU38J, LEU44I, LEU44J, LEU48I, LEU48J, LEU53I, LEU53J, LYS54I, LYS54J, LYS59I, LYS59J, PHE142J, PHE147I, PHE147J, PHE16I, PHE16J, PRO143I, PRO143J, PRO148I, PRO40I, PRO40J, PRO52I, PRO52J, PRO76I, PRO76J, SER45I, SER45J, THR74I, THR74J, THR7J, TRP144I, TRP144J, TRP8I, TRP8J, TRP9I, TRP9J, TYR61J, VAL11I, VAL11J, VAL29I, VAL33I, VAL42I, VAL42J, VAL55I, VAL55J
• I-K: ALA117I, ALA120I, ALA14I, ALA17I, ALA19I, ARG135I, ARG13I, ASP12I, ASP130I, ASP2K, CYS118I, GLN10I, GLN10K, GLU137I, GLU145K, GLU146K, GLU151K, GLU20I, GLU24I, ILE116I, ILE140I, ILE150K, ILE15I, LEU119I, LEU18I, LEU22I, LEU6I, LEU6K, LYS115I, LYS138I, LYS138K, LYS152K, LYS21I, LYS3I, LYS3K, MET121I, MET1K, PHE134I, PHE142K, PHE147K, PHE16I, PRO123I, PRO129I, PRO143K, PRO148K, SER126I, THR125I, THR136I, THR7I, THR7K, TRP144K, TRP8I, TRP8K, TRP9I, TRP9K, TYR131I, TYR132I, TYR25I, TYR5I, TYR5K, VAL11I, VAL127I, VAL128I, VAL133I, VAL141I, VAL141K, VAL149K, VAL4I, VAL4K
• I-L: ALA14I, ALA17I, ALA17L, ALA19I, ALA19L, ARG13I, ARG13L, ARG23I, ARG23L, ARG43I, ARG43L, ASP12I, ASP12L, GLN10I, GLU20I, GLU20L, GLY49I, HIS46I, ILE15I, ILE15L, ILE47I, ILE47L, LEU18L, LEU44L, LEU48I, LEU48L, LYS21I, LYS21L, PHE16I, PHE16L, TRP8I, TRP8L, TRP9I, TRP9L, VAL11L
• J-L: ALA117L, ALA120L, ALA14L, ALA17L, ALA19L, ARG135L, ARG13L, ARG23L, ASP12L, ASP130L, ASP2J, CYS118L, GLN10J, GLN10L, GLU137L, GLU145J, GLU146J, GLU151J, GLU20L, GLU24L, ILE116L, ILE140L, ILE150J, ILE15L, LEU119L, LEU18L, LEU22L, LEU6J, LEU6L, LYS115L, LYS122L, LYS138J, LYS138L, LYS152J, LYS21L, LYS3J, MET121L, MET1J, MET1L, PHE134L, PHE142J, PHE142L, PHE147J, PHE16L, PRO123L, PRO129L, PRO143J, PRO148J, SER126L, THR136L, THR7J, THR7L, TRP139L, TRP144J, TRP8J, TRP9J, TRP9L, TYR131L, TYR132L, TYR5J, TYR5L, VAL11J, VAL11L, VAL127L, VAL128L, VAL133L, VAL141J, VAL141L, VAL149J, VAL4J, VAL4L
• K-L: ALA34K, ALA34L, ALA41K, ALA41L, ARG23K, ARG23L, ARG35K, ARG35L, ARG43K, ARG43L, ASP12K, ASP12L, ASP50K, ASP50L, ASP57K, ASP57L, ASP91L, GLU145K, GLU145L, GLU146K, GLU146L, GLY32K, GLY32L, GLY36K, GLY36L, GLY37K, GLY37L, GLY49K, GLY49L, GLY79K, GLY79L, HIS46K, HIS46L, HIS78K, HIS78L, ILE15K, ILE15L, ILE30K, ILE30L, ILE39K, ILE39L, ILE47K, ILE47L, ILE51K, ILE51L, ILE56K, ILE56L, ILE73K, ILE75K, ILE75L, ILE77K, ILE77L, LEU38K, LEU38L, LEU44K, LEU44L, LEU48K, LEU48L, LEU53K, LEU53L, LYS54K, LYS54L, LYS59K, LYS59L, PHE142L, PHE147K, PHE147L, PHE16K, PHE16L, PRO143K, PRO143L, PRO148K, PRO40K, PRO40L, PRO52K, PRO52L, PRO76K, PRO76L, SER45K, SER45L, THR74K, THR74L, THR7L, TRP144K, TRP144L, TRP8K, TRP8L, TRP9K, TRP9L, TYR61L, VAL11K, VAL11L, VAL29L, VAL33L, VAL42K, VAL42L, VAL55K, VAL55L