1V7N

human thrombopoietin functional domain complexed to neutralizing antibody tn1 fab

• Total interactions analyzed: 66
• Total true interactions: 33
• Strongest Interaction:
  • Chains: H-V
  • Int. Res.: 52
  • Norm. En. per Res.: -2.9773
• Hub Node: M(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
L-H	-43.4394	-20.6525	-410.316	-474.4079	184	31	9	17146	1	18	13
L-O	-26.2901	-51.9852	-53.1276	-131.4029	69	3	0	3479	6	31	33
L-K	-3.8477	0.0	-58.7105	-62.5582	26	4	0	1839	0	0	0
L-V	-11.6129	0.0	-69.7008	-81.3137	41	9	1	2962	0	1	0
L-Y	0.0	-13.8769	-57.9181	-71.795	33	6	0	3009	0	21	18
L-Z	0.0	0.0	-0.0044	-0.0044	2	0	0	6	0	3	2
H-O	-4.8688	0.0	-57.8181	-62.6869	25	4	0	1946	0	0	0
H-K	0.0	0.0	-7.1714	-7.1714	17	0	0	359	0	2	2
H-V	-2.9121	-22.021	-129.886	-154.8191	52	15	2	5220	1	3	5
H-Y	-6.3016	-17.1696	-9.9271	-33.3984	14	2	0	479	3	8	5
H-Z	0.0	-10.5821	-84.959	-95.5411	51	3	1	4338	1	5	6
M-I	-39.6444	-20.8938	-419.307	-479.8452	188	22	10	17430	1	18	14
M-N	-35.4228	-55.1608	-41.7697	-132.3533	72	8	0	3328	5	30	33
M-J	0.0	0.0	-49.1103	-49.1103	24	4	0	1806	0	0	0
M-X	-5.9667	0.0	-76.6184	-82.5851	43	11	1	3288	0	1	1
M-Y	0.0	0.0	-0.0019	-0.0019	2	0	0	2	0	2	2
M-Z	0.0	-15.3681	-12.2825	-27.6506	21	0	0	841	1	8	6
I-N	-9.008	0.0	-54.9838	-63.9918	24	4	0	1849	0	0	0
I-J	0.0	0.0	-7.762	-7.762	18	1	0	393	0	2	2
I-X	-4.727	-21.0028	-136.818	-162.5478	55	8	2	5117	1	3	5
I-Y	-6.9041	-5.3967	-59.7524	-72.0532	52	24	3	4658	1	5	7
I-Z	0.0	-15.1239	-4.1953	-19.3192	10	0	0	296	0	9	5
N-J	-12.5401	-11.7437	-409.406	-433.6898	183	28	9	17301	1	19	14
N-X	0.0	0.0	-0.042	-0.042	2	0	0	8	0	2	1
N-Y	-2.8448	0.0	-80.0135	-82.8583	39	6	1	3134	0	1	0
J-X	-3.2626	-19.0993	-109.044	-131.4058	52	19	3	5094	3	5	6
J-Y	-2.6093	-16.1444	-139.479	-158.2327	54	11	2	5068	0	3	5
O-K	-55.9236	-19.9548	-409.285	-485.1634	189	46	9	17613	1	18	13
O-V	0.0	0.0	-0.0134	-0.0134	2	0	0	10	0	3	1
O-Z	-17.2482	0.0	-80.5491	-97.7973	40	11	0	3251	0	1	0
K-V	-7.6475	-0.3301	-82.3859	-90.3635	51	15	2	4098	0	4	7
K-Z	0.0	-18.8266	-127.772	-146.5986	51	15	1	4953	1	3	5
Y-Z	-6.4801	-27.8111	-99.4128	-133.704	80	16	3	6314	0	22	33

Interface residues

• L-H: ALA128H, ALA129L, ALA132H, ALA133H, ALA171H, ALA49H, ALA54L, ALA59H, ALA63H, ARG216H, ARG38H, ARG52H, ARG90L, ARG95L, ASN136H, ASN136L, ASN137L, ASN160L, ASN209L, ASN211L, ASP164L, ASP166L, ASP169L, ASP210H, ASP217H, ASP35H, CYS133L, CYS143H, CYS213L, CYS87L, CYS98H, GLN108H, GLN123L, GLN134H, GLN165L, GLN174H, GLN1L, GLN36L, GLN37L, GLN39H, GLN6L, GLN88L, GLN89L, GLU122L, GLU212L, GLU46H, GLU50H, GLU64H, GLU6H, GLY100H, GLY100L, GLY107H, GLY109H, GLY127L, GLY128L, GLY130H, GLY142H, GLY157L, GLY165H, GLY40L, GLY44H, GLY92L, GLY98L, GLY99L, HIS167H, HIS61H, ILE116L, ILE213H, ILE51H, ILE60H, ILE95H, LEU104H, LEU124L, LEU127H, LEU135L, LEU141H, LEU144H, LEU159L, LEU173H, LEU177H, LEU178L, LEU180H, LEU180L, LEU45H, LEU45L, LEU4H, LYS141L, LYS146H, LYS168L, LYS206L, LYS211H, LYS212H, LYS43H, LYS44L, LYS67H, MET138H, MET174L, PHE103H, PHE117L, PHE134L, PHE138L, PHE169H, PHE208L, PHE35L, PHE97L, PRO118L, PRO119L, PRO126H, PRO129H, PRO170H, PRO215H, PRO39L, PRO41H, PRO43L, PRO94L, SER102H, SER115L, SER120L, SER121L, SER123H, SER126L, SER130L, SER131H, SER161L, SER163H, SER164H, SER167L, SER173L, SER175H, SER175L, SER176L, SER181H, SER182H, SER183H, SER207L, SER40H, SER42L, SER55L, SER65H, SER99H, THR113L, THR125L, THR140H, THR163L, THR168H, THR171L, THR177L, THR179H, THR179L, THR185H, THR41L, THR84L, THR96L, TRP101H, TRP106H, TRP157H, TRP162L, TRP33H, TRP36H, TRP46L, TRP47H, TYR105H, TYR125H, TYR172L, TYR178H, TYR33L, TYR48L, TYR62H, TYR85L, TYR86L, TYR93L, TYR97H, VAL114L, VAL124H, VAL131L, VAL132L, VAL139H, VAL145H, VAL158L, VAL166H, VAL172H, VAL184H, VAL37H, VAL48H
• L-O: ALA108L, ALA108O, ALA110L, ALA110O, ALA111L, ALA111O, ALA59L, ALA59O, ALA79L, ALA79O, ARG107L, ARG107O, ARG60L, ARG60O, ARG76L, ARG76O, ASN137L, ASN137O, ASP109L, ASP109O, ASP169L, ASP169O, GLU17L, GLU17O, GLU78L, GLU78O, GLU80L, GLU80O, GLY16L, GLY16O, HIS197L, HIS197O, ILE105L, ILE105O, ILE204O, LYS168L, LYS168O, LYS198L, LYS198O, MET77L, MET77O, PHE138L, PHE138O, PRO112L, PRO112O, PRO140L, PRO140O, PRO15L, PRO15O, PRO58L, PRO58O, SER14L, SER14O, SER167O, SER170L, SER170O, SER200L, SER200O, SER75L, SER75O, THR113L, THR113O, THR171L, THR171O, THR199L, THR199O, THR201L, TYR139L, TYR139O
• L-K: ALA54L, ALA59L, ARG60L, ASN136K, ASN52L, GLU80L, GLY56L, LEU53L, LYS168L, MET138K, PHE61L, PRO187K, PRO58L, SER137K, SER164K, SER188K, SER189K, SER55L, THR185K, THR190K, TRP191K, TRP46L, TYR48L, VAL139K, VAL186K, VAL57L
• L-V: ALA54L, ALA60V, ARG115V, ARG90L, ARG95L, ASN52L, ASP62V, GLN105V, GLN111V, GLN54V, GLN61V, GLN88L, GLU56V, GLU57V, GLY109V, GLY116V, GLY65V, GLY92L, ILE47L, LEU108V, LEU112V, LEU45L, LEU53L, LEU64V, LYS59V, MET55V, PRO113V, PRO114V, SER30L, SER49L, SER51L, SER55L, SER91L, THR110V, THR50L, THR58V, TYR31L, TYR33L, TYR48L, TYR93L, VAL29L
• L-Y: ARG10Y, ARG136Y, ARG140Y, ARG17Y, ARG187L, ARG210L, ASN189L, ASN209L, ASN211L, ASP150L, ASP8Y, CYS213L, GLU186L, GLU212L, HIS188L, HIS20Y, LEU124L, LEU12Y, LEU135Y, LEU144Y, LEU15Y, LEU16Y, LEU9Y, LYS14Y, LYS182L, MET143Y, PHE141Y, PHE208L, SER13Y, SER190L, TYR185L, VAL11Y, VAL139Y
• L-Z: GLU212L, THR119Z
• H-O: ALA54O, ALA59O, ARG60O, ASN136H, ASN52O, GLY56O, ILE47O, LEU45O, LEU53O, MET138H, PHE61O, PRO187H, PRO58O, SER137H, SER188H, SER189H, SER55O, THR185H, THR190H, TRP191H, TRP46O, TYR48O, VAL139H, VAL186H, VAL57O
• H-K: GLU194H, GLU194K, GLU1H, GLU1K, GLY26H, LEU104H, LEU104K, SER189H, SER189K, SER193H, SER193K, THR190H, THR190K, TYR105H, TYR105K, VAL2H, VAL2K
• H-V: ALA103V, ALA32H, ARG52H, ARG74H, ARG98V, ASN56H, ASN57H, ASP31H, ASP35H, GLN105V, GLN111V, GLU50H, GLU72V, GLY100H, GLY102V, GLY109V, GLY95V, ILE51H, LEU100V, LEU101V, LEU104H, LEU104V, LEU107V, LEU108V, LEU112V, LEU150V, LEU64V, LEU69V, LEU71V, LEU99V, LYS54H, MET34H, MET75V, PHE103H, PHE27H, PHE29H, PRO113V, PRO114V, SER102H, SER106V, SER30H, SER53H, SER94V, SER99H, THR110V, THR28H, THR68V, TRP101H, TRP33H, TYR105H, VAL55H, VAL97V
• H-Y: ALA132H, ARG140Y, ARG17Y, ARG216H, ARG25Y, ASP217H, GLN132Y, HIS20Y, HIS23Y, LEU16Y, SER131H, SER24Y, SER27Y, VAL21Y
• H-Z: ALA120Z, ALA126Z, ALA128H, ALA132H, ALA133H, ALA43Z, ALA76Z, ARG115Z, ARG117Z, ARG216H, ASN125Z, ASN136H, ASP123Z, ASP217H, GLN134H, GLU72Z, GLY116Z, GLY130H, HIS121Z, ILE127Z, ILE213H, LEU35Z, LEU40Z, LEU41Z, LEU69Z, LYS122Z, LYS211H, PRO113Z, PRO114Z, PRO124Z, PRO129H, PRO192H, PRO215H, PRO34Z, PRO36Z, PRO38Z, SER131H, SER137H, SER188H, SER189H, SER193H, THR118Z, THR119Z, THR135H, THR195H, THR37Z, TRP191H, VAL139H, VAL214H, VAL39Z, VAL44Z
• M-I: ALA128I, ALA129M, ALA132I, ALA133I, ALA171I, ALA49I, ALA54M, ALA59I, ALA63I, ARG210M, ARG216I, ARG38I, ARG52I, ARG90M, ARG95M, ASN136I, ASN136M, ASN137M, ASN160M, ASN209M, ASN211M, ASP164M, ASP166M, ASP169M, ASP210I, ASP217I, ASP35I, CYS133M, CYS143I, CYS87M, CYS98I, GLN108I, GLN123M, GLN134I, GLN165M, GLN174I, GLN1M, GLN36M, GLN37M, GLN39I, GLN6M, GLN88M, GLN89M, GLU122M, GLU212M, GLU46I, GLU50I, GLU64I, GLU6I, GLY100I, GLY100M, GLY107I, GLY109I, GLY127M, GLY128M, GLY130I, GLY142I, GLY157M, GLY165I, GLY40M, GLY44I, GLY92M, GLY98M, GLY99M, HIS167I, HIS61I, ILE116M, ILE213I, ILE51I, ILE60I, ILE95I, LEU104I, LEU124M, LEU127I, LEU135M, LEU141I, LEU144I, LEU159M, LEU173I, LEU177I, LEU178M, LEU180I, LEU180M, LEU45I, LEU45M, LEU4I, LYS141M, LYS146I, LYS168M, LYS206M, LYS211I, LYS212I, LYS38M, LYS43I, LYS44M, LYS67I, MET138I, MET174M, PHE103I, PHE117M, PHE134M, PHE138M, PHE169I, PHE208M, PHE35M, PHE97M, PRO118M, PRO119M, PRO126I, PRO129I, PRO170I, PRO215I, PRO39M, PRO41I, PRO43M, PRO94M, SER102I, SER115M, SER120M, SER121M, SER123I, SER126M, SER130M, SER131I, SER161M, SER163I, SER164I, SER167M, SER173M, SER175I, SER175M, SER176M, SER181I, SER182I, SER183I, SER207M, SER40I, SER42M, SER55M, SER65I, SER99I, THR113M, THR125M, THR135I, THR140I, THR163M, THR168I, THR171M, THR177M, THR179I, THR179M, THR185I, THR41M, THR84M, THR96M, TRP101I, TRP106I, TRP157I, TRP162M, TRP33I, TRP34M, TRP36I, TRP46M, TRP47I, TYR105I, TYR125I, TYR172M, TYR178I, TYR33M, TYR48M, TYR62I, TYR85M, TYR86M, TYR93M, TYR97I, VAL114M, VAL124I, VAL131M, VAL132M, VAL139I, VAL145I, VAL158M, VAL166I, VAL172I, VAL184I, VAL37I, VAL3M, VAL48I
• M-N: ALA108M, ALA108N, ALA110M, ALA110N, ALA111M, ALA111N, ALA59M, ALA59N, ALA79M, ALA79N, ARG107M, ARG107N, ARG60M, ARG60N, ARG76M, ARG76N, ASN137M, ASN137N, ASP109M, ASP109N, ASP169M, ASP169N, GLU17M, GLU17N, GLU78M, GLU78N, GLU80M, GLU80N, GLY16M, GLY16N, HIS197M, HIS197N, ILE105M, ILE105N, ILE204M, LYS168M, LYS168N, LYS198M, LYS198N, MET77M, MET77N, PHE138M, PHE138N, PRO112M, PRO112N, PRO140M, PRO140N, PRO15M, PRO15N, PRO58M, PRO58N, SER14M, SER14N, SER167M, SER167N, SER170M, SER170N, SER200M, SER200N, SER75M, SER75N, THR113M, THR113N, THR171M, THR171N, THR199M, THR199N, THR201M, THR201N, TYR139M, TYR139N, VAL114N
• M-J: ALA54M, ALA59M, ARG60M, ASN136J, ASN52M, GLU80M, GLY56M, LEU53M, MET138J, PHE61M, PRO187J, PRO58M, SER137J, SER188J, SER189J, SER55M, THR135J, THR190J, TRP191J, TRP46M, TYR48M, VAL139J, VAL186J, VAL57M
• M-X: ALA54M, ALA60X, ARG115X, ARG90M, ARG95M, ASN52M, ASP62X, GLN111X, GLN54X, GLN61X, GLN88M, GLU56X, GLU57X, GLY109X, GLY116X, GLY65X, GLY67M, GLY92M, ILE47M, LEU108X, LEU112X, LEU45M, LEU53M, LEU64X, LYS59X, MET32M, MET55X, PRO113X, PRO114X, SER30M, SER49M, SER51M, SER55M, SER66M, SER91M, THR110X, THR50M, THR58X, TYR31M, TYR33M, TYR48M, TYR93M, VAL29M
• M-Y: GLU212M, THR119Y
• M-Z: ARG10Z, ARG140Z, ARG17Z, ARG187M, ARG210M, ASN189M, ASN209M, ASN211M, GLU186M, GLU212M, GLY146Z, HIS188M, LEU124M, LEU12Z, LEU144Z, LEU16Z, LEU9Z, MET143Z, SER121M, SER13Z, VAL145Z
• I-N: ALA54N, ALA59N, ARG60N, ASN136I, ASN52N, GLU80N, GLY56N, LEU53N, MET138I, PHE61N, PRO187I, PRO58N, SER137I, SER188I, SER189I, SER55N, THR185I, THR190I, TRP191I, TRP46N, TYR48N, VAL139I, VAL186I, VAL57N
• I-J: GLU194I, GLU194J, GLU1I, GLU1J, GLY26I, GLY26J, LEU104I, LEU104J, SER189I, SER189J, SER193I, SER193J, THR190I, THR190J, TYR105I, TYR105J, VAL2I, VAL2J
• I-X: ALA103X, ALA32I, ALA59I, ARG52I, ARG74I, ARG98X, ASN56I, ASN57I, ASP31I, ASP35I, GLN105X, GLN111X, GLN96X, GLU50I, GLU72X, GLY100I, GLY102X, GLY109X, GLY65X, GLY95X, HIS61I, ILE51I, LEU100X, LEU101X, LEU104I, LEU104X, LEU107X, LEU108X, LEU112X, LEU64X, LEU69X, LEU71X, LEU99X, LYS54I, MET34I, MET75X, PHE103I, PHE27I, PHE29I, PRO113X, PRO114X, SER102I, SER106X, SER30I, SER53I, SER94X, THR110X, THR28I, THR68X, TRP101I, TRP33I, TYR105I, VAL55I, VAL67X, VAL97X
• I-Y: ALA120Y, ALA126Y, ALA132I, ALA133I, ALA43Y, ALA76Y, ARG115Y, ARG117Y, ARG216I, ASN125Y, ASN136I, ASP123Y, ASP217I, GLN134I, GLU194I, GLU72Y, GLY116Y, GLY130I, GLY73Y, HIS121Y, ILE127Y, ILE213I, LEU35Y, LEU40Y, LEU41Y, LEU69Y, LYS122Y, LYS211I, LYS212I, PRO113Y, PRO114Y, PRO124Y, PRO129I, PRO192I, PRO215I, PRO34Y, PRO36Y, PRO38Y, SER131I, SER137I, SER188I, SER189I, SER193I, THR118Y, THR119Y, THR135I, THR195I, THR37Y, TRP191I, VAL139I, VAL214I, VAL39Y
• I-Z: ALA132I, ARG136Z, ARG140Z, ARG17Z, ARG216I, ASP217I, GLN132Z, HIS20Z, LEU16Z, SER131I
• N-J: ALA128J, ALA129N, ALA132J, ALA133J, ALA171J, ALA49J, ALA54N, ALA59J, ALA63J, ARG210N, ARG216J, ARG38J, ARG52J, ARG90N, ARG95N, ASN136J, ASN136N, ASN137N, ASN160N, ASN209N, ASN211N, ASP164N, ASP166N, ASP169N, ASP210J, ASP217J, ASP35J, CYS133N, CYS143J, CYS87N, CYS98J, GLN108J, GLN123N, GLN134J, GLN165N, GLN174J, GLN1N, GLN36N, GLN37N, GLN39J, GLN6N, GLN88N, GLN89N, GLU122N, GLU212N, GLU42J, GLU46J, GLU50J, GLU64J, GLU6J, GLY100J, GLY100N, GLY107J, GLY109J, GLY128N, GLY130J, GLY142J, GLY157N, GLY165J, GLY40N, GLY44J, GLY92N, GLY98N, GLY99N, HIS167J, HIS61J, ILE116N, ILE60J, ILE95J, LEU104J, LEU124N, LEU127J, LEU135N, LEU141J, LEU144J, LEU159N, LEU173J, LEU177J, LEU178N, LEU180J, LEU180N, LEU45J, LEU45N, LEU4J, LYS141N, LYS146J, LYS168N, LYS206N, LYS211J, LYS212J, LYS43J, LYS44N, LYS67J, MET138J, MET174N, PHE103J, PHE117N, PHE134N, PHE138N, PHE169J, PHE208N, PHE35N, PHE97N, PRO118N, PRO119N, PRO126J, PRO129J, PRO170J, PRO215J, PRO39N, PRO41J, PRO43N, PRO94N, SER102J, SER115N, SER120N, SER121N, SER123J, SER126N, SER130N, SER131J, SER161N, SER163J, SER164J, SER167N, SER173N, SER175J, SER175N, SER176N, SER181J, SER182J, SER183J, SER207N, SER42N, SER55N, SER65J, SER99J, THR113N, THR125N, THR140J, THR163N, THR168J, THR171N, THR177N, THR179J, THR179N, THR185J, THR41N, THR84N, THR96N, TRP101J, TRP106J, TRP157J, TRP162N, TRP33J, TRP36J, TRP46N, TRP47J, TYR105J, TYR125J, TYR172N, TYR185N, TYR33N, TYR48N, TYR62J, TYR85N, TYR86N, TYR93N, TYR96J, TYR97J, VAL114N, VAL124J, VAL131N, VAL132N, VAL139J, VAL145J, VAL158N, VAL166J, VAL172J, VAL184J, VAL37J, VAL48J, VAL66J
• N-X: GLU212N, THR119X
• N-Y: ALA54N, ALA60Y, ARG115Y, ARG90N, ARG95N, ASN52N, ASP62Y, GLN111Y, GLN54Y, GLN61Y, GLN88N, GLU56Y, GLU57Y, GLY109Y, GLY116Y, GLY65Y, GLY92N, LEU108Y, LEU112Y, LEU45N, LEU53N, LYS59Y, MET55Y, PRO113Y, PRO114Y, SER30N, SER49N, SER51N, SER55N, SER66N, SER91N, THR110Y, THR50N, THR58Y, TYR31N, TYR33N, TYR48N, TYR93N, VAL29N
• J-X: ALA120X, ALA126X, ALA132J, ALA133J, ALA43X, ALA76X, ARG115X, ARG117X, ARG216J, ASN125X, ASN136J, ASP123X, ASP217J, GLN134J, GLN80X, GLU72X, GLY116X, GLY130J, GLY73X, HIS121X, ILE127X, ILE213J, LEU129X, LEU35X, LEU40X, LEU41X, LEU69X, LYS122X, LYS211J, LYS212J, PRO114X, PRO124X, PRO129J, PRO192J, PRO215J, PRO34X, PRO36X, PRO38X, SER131J, SER188J, SER189J, SER193J, THR118X, THR119X, THR135J, THR195J, THR37X, TRP191J, VAL139J, VAL214J, VAL39X, VAL44X
• J-Y: ALA103Y, ALA32J, ALA59J, ARG52J, ARG74J, ARG98Y, ASN56J, ASN57J, ASP31J, ASP35J, GLN105Y, GLN111Y, GLN96Y, GLU50J, GLU72Y, GLY100J, GLY102Y, GLY109Y, GLY95Y, HIS61J, ILE51J, LEU100Y, LEU101Y, LEU104J, LEU104Y, LEU107Y, LEU108Y, LEU112Y, LEU64Y, LEU69Y, LEU71Y, LEU99Y, LYS54J, MET34J, MET75Y, PHE103J, PHE27J, PHE29J, PRO113Y, PRO114Y, SER102J, SER106Y, SER30J, SER53J, SER94Y, THR110Y, THR28J, THR68Y, TRP101J, TRP33J, TYR105J, VAL55J, VAL67Y, VAL97Y
• O-K: ALA128K, ALA129O, ALA132K, ALA133K, ALA171K, ALA49K, ALA54O, ALA59K, ALA63K, ARG210O, ARG216K, ARG38K, ARG52K, ARG90O, ARG95O, ASN136K, ASN136O, ASN137O, ASN160O, ASN209O, ASN211O, ASP164O, ASP166O, ASP169O, ASP210K, ASP217K, ASP35K, CYS133O, CYS143K, CYS213O, CYS87O, CYS98K, GLN108K, GLN123O, GLN134K, GLN165O, GLN174K, GLN1O, GLN36O, GLN37O, GLN39K, GLN6O, GLN88O, GLN89O, GLU122O, GLU212O, GLU42K, GLU46K, GLU50K, GLU64K, GLU6K, GLY100K, GLY100O, GLY107K, GLY109K, GLY128O, GLY130K, GLY142K, GLY157O, GLY165K, GLY40O, GLY44K, GLY92O, GLY98O, GLY99O, HIS167K, HIS61K, ILE116O, ILE213K, ILE51K, ILE60K, ILE95K, LEU104K, LEU124O, LEU127K, LEU135O, LEU141K, LEU144K, LEU159O, LEU173K, LEU177K, LEU178O, LEU180K, LEU180O, LEU45K, LEU45O, LEU4K, LEU53O, LYS141O, LYS146K, LYS168O, LYS206O, LYS211K, LYS212K, LYS38O, LYS43K, LYS44O, LYS67K, MET138K, MET174O, PHE103K, PHE117O, PHE134O, PHE138O, PHE169K, PHE208O, PHE35O, PHE97O, PRO118O, PRO119O, PRO126K, PRO129K, PRO170K, PRO215K, PRO39O, PRO41K, PRO43O, PRO94O, SER102K, SER115O, SER120O, SER121O, SER123K, SER126O, SER130O, SER131K, SER161O, SER163K, SER164K, SER167O, SER173O, SER175K, SER175O, SER176O, SER181K, SER182K, SER183K, SER207O, SER40K, SER42O, SER55O, SER65K, SER99K, THR113O, THR125O, THR135K, THR140K, THR163O, THR168K, THR171O, THR177O, THR179K, THR179O, THR185K, THR41O, THR84O, THR96O, TRP101K, TRP106K, TRP157K, TRP162O, TRP33K, TRP34O, TRP36K, TRP46O, TRP47K, TYR105K, TYR125K, TYR172O, TYR33O, TYR48O, TYR62K, TYR85O, TYR86O, TYR93O, TYR97K, VAL114O, VAL124K, VAL131O, VAL132O, VAL139K, VAL145K, VAL158O, VAL166K, VAL172K, VAL184K, VAL37K, VAL3O, VAL48K
• O-V: GLU212O, THR119V
• O-Z: ALA54O, ALA60Z, ARG115Z, ARG90O, ARG95O, ASN52O, ASP62Z, GLN111Z, GLN54Z, GLN61Z, GLN88O, GLU56Z, GLU57Z, GLY109Z, GLY116Z, GLY65Z, GLY92O, ILE47O, LEU108Z, LEU112Z, LEU45O, LEU53O, LEU64Z, LYS59Z, MET55Z, PRO113Z, PRO114Z, SER30O, SER49O, SER51O, SER55O, SER91O, THR110Z, THR50O, THR58Z, TYR31O, TYR33O, TYR48O, TYR93O, VAL29O
• K-V: ALA120V, ALA126V, ALA132K, ALA133K, ALA43V, ALA76V, ARG115V, ARG117V, ARG216K, ASN125V, ASN136K, ASP123V, ASP217K, GLN134K, GLN80V, GLU194K, GLU72V, GLY116V, GLY130K, HIS121V, ILE127V, ILE213K, LEU35V, LEU40V, LEU41V, LEU69V, LYS122V, LYS211K, LYS212K, PRO113V, PRO114V, PRO124V, PRO129K, PRO192K, PRO215K, PRO34V, PRO36V, PRO38V, SER131K, SER188K, SER189K, SER193K, THR118V, THR119V, THR135K, THR195K, THR37V, TRP191K, VAL139K, VAL214K, VAL39V
• K-Z: ALA103Z, ALA32K, ARG52K, ARG74K, ARG98Z, ASN56K, ASN57K, ASP31K, ASP35K, GLN105Z, GLN111Z, GLU50K, GLU72Z, GLY100K, GLY102Z, GLY109Z, GLY95Z, ILE51K, LEU100Z, LEU101Z, LEU104K, LEU104Z, LEU107Z, LEU108Z, LEU112Z, LEU64Z, LEU69Z, LEU71Z, LEU99Z, LYS54K, MET34K, MET75Z, PHE103K, PHE27K, PHE29K, PRO113Z, PRO114Z, SER102K, SER106Z, SER30K, SER53K, SER94Z, SER99K, THR110Z, THR28K, THR68Z, TRP101K, TRP33K, TYR105K, VAL55K, VAL97Z
• Y-Z: ALA126Y, ALA126Z, ARG136Y, ARG136Z, ARG140Y, ARG140Z, ARG25Y, ARG25Z, ASN125Y, ASN125Z, ASP123Y, ASP123Z, ASP45Y, ASP45Z, CYS29Y, CYS29Z, GLN132Y, GLN132Z, GLN28Y, GLN28Z, GLU31Y, GLU31Z, GLU50Z, GLY137Y, GLY137Z, GLY49Y, GLY49Z, HIS121Y, HIS121Z, HIS133Y, HIS133Z, HIS20Y, HIS20Z, HIS23Y, HIS23Z, HIS33Y, HIS33Z, LEU129Y, LEU129Z, LEU134Y, LEU134Z, LEU135Z, LEU26Y, LEU26Z, LEU48Y, LEU48Z, LEU86Z, LYS122Y, LYS122Z, LYS138Z, LYS52Y, LYS52Z, PHE128Y, PHE128Z, PHE141Y, PHE141Z, PHE46Y, PHE46Z, PRO124Y, PRO124Z, PRO30Y, PRO30Z, PRO34Y, PRO34Z, SER130Y, SER24Y, SER24Z, SER27Y, SER27Z, SER47Y, SER47Z, THR119Y, THR119Z, THR53Z, TRP51Z, VAL21Z, VAL32Y, VAL32Z, VAL44Y, VAL44Z