1V7M

human thrombopoietin functional domain complexed to neutralizing antibody tn1 fab

• Total interactions analyzed: 15
• Total true interactions: 8
• Strongest Interaction:
  • Chains: H-X
  • Int. Res.: 10
  • Norm. En. per Res.: -5.1043
• Hub Node: L(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
L-H	-16.489	-4.9532	-398.543	-419.9852	180	6	9	16234	1	18	13
L-V	-3.7694	0.0	-71.3178	-75.0872	39	3	1	2923	0	1	0
L-X	0.0	-7.4643	-32.0421	-39.5064	23	2	0	1724	0	12	5
H-V	-4.4715	-20.4397	-123.724	-148.6352	55	11	1	5063	1	3	5
H-X	-24.8992	-17.4507	-8.6928	-51.0427	10	5	0	519	0	5	5
M-I	-18.8661	14.4259	-412.822	-417.2622	179	9	10	16591	1	19	13
M-X	0.0	0.0	-83.152	-83.152	41	3	0	2948	0	1	0
I-X	-9.1999	-25.3799	-125.924	-160.5038	54	10	1	4854	1	3	5

Interface residues

• L-H: ALA128H, ALA129L, ALA132H, ALA133H, ALA171H, ALA49H, ALA54L, ALA59H, ALA63H, ARG216H, ARG38H, ARG52H, ARG90L, ARG95L, ASN136H, ASN136L, ASN137L, ASN160L, ASN209L, ASN211L, ASP164L, ASP166L, ASP169L, ASP210H, ASP217H, ASP35H, CYS133L, CYS143H, CYS87L, CYS98H, GLN108H, GLN123L, GLN134H, GLN165L, GLN174H, GLN1L, GLN36L, GLN37L, GLN39H, GLN6L, GLN88L, GLN89L, GLU122L, GLU212L, GLU42H, GLU46H, GLU50H, GLU64H, GLU6H, GLY100L, GLY107H, GLY109H, GLY127L, GLY128L, GLY130H, GLY142H, GLY157L, GLY165H, GLY40L, GLY44H, GLY92L, GLY98L, GLY99L, HIS167H, HIS61H, ILE116L, ILE213H, ILE95H, LEU104H, LEU124L, LEU127H, LEU135L, LEU141H, LEU144H, LEU159L, LEU173H, LEU177H, LEU178L, LEU180H, LEU180L, LEU45H, LEU45L, LYS146H, LYS168L, LYS206L, LYS208H, LYS211H, LYS212H, LYS43H, LYS44L, MET138H, MET174L, PHE103H, PHE117L, PHE134L, PHE138L, PHE169H, PHE208L, PHE35L, PHE97L, PRO118L, PRO119L, PRO126H, PRO129H, PRO170H, PRO215H, PRO39L, PRO41H, PRO43L, PRO94L, SER102H, SER115L, SER120L, SER121L, SER123H, SER126L, SER130L, SER131H, SER161L, SER163H, SER164H, SER167L, SER173L, SER175H, SER175L, SER176L, SER181H, SER182H, SER183H, SER207L, SER40H, SER42L, SER55L, SER65H, SER99H, THR113L, THR125L, THR140H, THR163L, THR168H, THR171L, THR177L, THR179H, THR179L, THR185H, THR41L, THR84L, THR96L, TRP101H, TRP106H, TRP157H, TRP162L, TRP191H, TRP33H, TRP36H, TRP46L, TRP47H, TYR105H, TYR125H, TYR172L, TYR178H, TYR33L, TYR48L, TYR62H, TYR85L, TYR86L, TYR93L, TYR97H, VAL114L, VAL124H, VAL131L, VAL132L, VAL139H, VAL145H, VAL158L, VAL166H, VAL172H, VAL184H, VAL37H, VAL48H
• L-V: ALA54L, ALA60V, ARG90L, ARG95L, ASN52L, ASP62V, GLN111V, GLN115V, GLN61V, GLN88L, GLU56V, GLU57V, GLY109V, GLY116V, GLY65V, GLY92L, ILE47L, LEU108V, LEU112V, LEU45L, LEU53L, LEU64V, LYS59V, MET55V, PRO113V, PRO114V, SER30L, SER49L, SER51L, SER55L, SER91L, THR110V, THR50L, THR58V, TYR31L, TYR33L, TYR48L, TYR93L, VAL29L
• L-X: ARG140X, ARG187L, ARG210L, ASN189L, ASN209L, ASN211L, GLU186L, GLU212L, GLU56X, GLY146X, HIS188L, LEU142X, LEU144X, LEU9X, LYS182L, LYS52X, LYS59X, MET143X, PHE141X, PHE208L, TRP51X, TYR185L, VAL145X
• H-V: ALA103V, ALA32H, ALA76V, ARG52H, ARG74H, ARG98V, ASN56H, ASN57H, ASP31H, ASP35H, GLN105V, GLN111V, GLU1H, GLU50H, GLU72V, GLY100H, GLY102V, GLY109V, GLY65V, GLY95V, HIS61H, ILE51H, LEU100V, LEU101V, LEU104H, LEU104V, LEU107V, LEU108V, LEU112V, LEU64V, LEU69V, LEU71V, LEU99V, LYS54H, MET34H, MET75V, PHE103H, PHE27H, PHE29H, PRO113V, PRO114V, SER102H, SER106V, SER30H, SER53H, SER94V, THR110V, THR28H, THR68V, TRP101H, TRP33H, TYR105H, VAL55H, VAL67V, VAL97V
• H-X: ARG136X, ARG140X, ARG216H, ASP217H, GLN132X, HIS20X, LEU16X, PHE141X, PHE46X, SER131H
• M-I: ALA128I, ALA129M, ALA132I, ALA133I, ALA171I, ALA49I, ALA54M, ALA59I, ALA63I, ARG210M, ARG216I, ARG38I, ARG52I, ARG90M, ARG95M, ASN136I, ASN136M, ASN137M, ASN160M, ASN209M, ASN211M, ASP164M, ASP166M, ASP169M, ASP210I, ASP217I, ASP35I, CYS133M, CYS143I, CYS87M, CYS98I, GLN108I, GLN123M, GLN134I, GLN174I, GLN1M, GLN36M, GLN37M, GLN39I, GLN6M, GLN88M, GLN89M, GLU122M, GLU212M, GLU46I, GLU50I, GLU64I, GLU6I, GLY100M, GLY107I, GLY109I, GLY128M, GLY130I, GLY142I, GLY157M, GLY165I, GLY40M, GLY44I, GLY92M, GLY98M, GLY99M, HIS167I, HIS61I, ILE116M, ILE213I, ILE95I, LEU104I, LEU124M, LEU127I, LEU135M, LEU141I, LEU144I, LEU159M, LEU173I, LEU177I, LEU180I, LEU180M, LEU45I, LEU45M, LEU4I, LYS141M, LYS146I, LYS168M, LYS206M, LYS208I, LYS211I, LYS212I, LYS43I, LYS44M, MET138I, MET174M, PHE103I, PHE117M, PHE134M, PHE138M, PHE169I, PHE208M, PHE35M, PHE97M, PRO118M, PRO119M, PRO126I, PRO129I, PRO170I, PRO215I, PRO39M, PRO41I, PRO43M, PRO94M, SER102I, SER115M, SER120M, SER121M, SER123I, SER126M, SER130M, SER131I, SER161M, SER163I, SER164I, SER167M, SER173M, SER175I, SER175M, SER176M, SER181I, SER182I, SER183I, SER207M, SER40I, SER42M, SER55M, SER65I, SER99I, THR113M, THR125M, THR140I, THR163M, THR168I, THR171M, THR177M, THR179I, THR179M, THR185I, THR41M, THR84M, THR96M, TRP101I, TRP106I, TRP157I, TRP162M, TRP191I, TRP33I, TRP36I, TRP46M, TRP47I, TYR105I, TYR125I, TYR172M, TYR178I, TYR33M, TYR48M, TYR62I, TYR85M, TYR86M, TYR93M, TYR97I, VAL114M, VAL124I, VAL131M, VAL132M, VAL139I, VAL158M, VAL166I, VAL172I, VAL184I, VAL2I, VAL37I, VAL48I
• M-X: ALA54M, ALA60X, ARG90M, ARG95M, ASN52M, ASP62X, GLN105X, GLN111X, GLN115X, GLN54X, GLN61X, GLN88M, GLU56X, GLU57X, GLY109X, GLY116X, GLY65X, GLY92M, ILE47M, LEU108X, LEU112X, LEU45M, LEU53M, LEU64X, LYS59X, MET55X, PRO113X, PRO114X, SER30M, SER49M, SER51M, SER55M, SER91M, THR110X, THR50M, THR58X, TYR31M, TYR33M, TYR48M, TYR93M, VAL29M
• I-X: ALA103X, ALA32I, ARG52I, ARG74I, ARG98X, ASN56I, ASN57I, ASP31I, ASP35I, CYS151X, GLN105X, GLN111X, GLU50I, GLU72X, GLY100I, GLY102X, GLY109X, GLY65X, GLY95X, HIS61I, ILE51I, LEU100X, LEU101X, LEU104I, LEU104X, LEU107X, LEU108X, LEU112X, LEU64X, LEU69X, LEU71X, LEU99X, LYS54I, MET34I, MET75X, PHE103I, PHE27I, PHE29I, PRO113X, PRO114X, SER102I, SER106X, SER30I, SER53I, SER94X, THR110X, THR28I, THR68X, TRP101I, TRP33I, TYR105I, VAL55I, VAL67X, VAL97X