1UXH

large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface

• Total interactions analyzed: 1
• Total true interactions: 1
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 194
  • Norm. En. per Res.: -4.1056
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-139.6409	-15.9009	-640.946	-796.4878	194	25	27	24507	4	48	33

Interface residues

• A-B: ALA10A, ALA10B, ALA149A, ALA149B, ALA150A, ALA150B, ALA157A, ALA157B, ALA18A, ALA18B, ALA225A, ALA225B, ALA228A, ALA228B, ALA22A, ALA22B, ALA230A, ALA230B, ALA231A, ALA231B, ALA232A, ALA232B, ALA234A, ALA234B, ALA23A, ALA23B, ALA43A, ALA43B, ALA49A, ALA49B, ARG151A, ARG151B, ARG153A, ARG153B, ARG208A, ARG208B, ARG246A, ARG246B, ARG2A, ARG2B, ARG58A, ARG58B, ASN218A, ASN218B, ASP148A, ASP148B, ASP166A, ASP166B, ASP45A, ASP45B, ASP56A, ASP56B, GLN143A, GLN143B, GLN165A, GLN165B, GLN168A, GLN168B, GLN235A, GLN235B, GLN40A, GLN40B, GLU159A, GLU215A, GLU215B, GLU238A, GLU238B, GLU25A, GLU25B, GLU36A, GLU36B, GLU48A, GLU48B, GLU53A, GLU53B, GLY11A, GLY11B, GLY145A, GLY145B, GLY14A, GLY14B, GLY161A, GLY161B, GLY212A, GLY212B, GLY213A, GLY213B, GLY223A, GLY223B, GLY37A, GLY37B, GLY41A, GLY41B, GLY54A, GLY54B, GLY61A, GLY61B, HIS19A, HIS19B, ILE156A, ILE156B, ILE216A, ILE216B, ILE52A, ILE52B, LEU147A, LEU147B, LEU219A, LEU219B, LEU21A, LEU21B, LEU220A, LEU220B, LEU31A, LEU31B, LEU44A, LEU44B, LEU46A, LEU46B, LYS221A, LYS221B, LYS24A, LYS24B, LYS42A, LYS42B, MET158A, MET158B, MET236A, MET236B, MET248A, MET248B, PHE12A, PHE12B, PHE155A, PHE155B, PHE55A, PHE55B, PRO229A, PRO229B, PRO39A, PRO39B, PRO51A, PRO51B, SER15A, SER15B, SER163A, SER163B, SER224A, SER224B, SER50A, SER50B, THR154A, THR154B, THR16A, THR16B, THR17A, THR17B, THR209A, THR209B, THR222A, THR222B, THR233A, THR233B, THR60B, TRP20A, TRP20B, TYR152A, TYR152B, TYR226A, TYR226B, TYR227A, TYR227B, TYR47A, TYR47B, VAL13A, VAL13B, VAL146A, VAL146B, VAL162A, VAL162B, VAL164A, VAL164B, VAL167A, VAL167B, VAL217A, VAL217B, VAL35A, VAL35B, VAL38A, VAL38B, VAL57A, VAL57B, VAL59A, VAL59B