1UW4

the structural basis of the interaction between nonsense mediated decay factors upf2 and upf3

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 92
  • Norm. En. per Res.: -4.4936
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-48.2764	-104.1753	-260.958	-413.4097	92	6	9	11053	12	34	30
A-D	-6.3924	-54.4519	-40.1134	-100.9577	34	4	0	1716	4	14	15
B-C	-7.6461	-53.1564	-36.1975	-97.0	32	1	0	1670	5	12	15
B-D	-36.718	21.4077	-220.44	-235.7503	79	9	9	9077	0	6	11
C-D	-43.218	-91.5409	-260.69	-395.4489	91	6	8	10926	10	34	30

Interface residues

• A-B: ALA134A, ALA139A, ALA140A, ALA887B, ALA95A, ARG56A, ARG57A, ARG854B, ARG867B, ARG868B, ARG882B, ARG891B, ARG96A, ASN815B, ASN818B, ASN85A, ASN860B, ASN865B, ASP807B, ASP840B, ASP847B, ASP852B, ASP86A, CYS811B, CYS812B, GLN137A, GLN803B, GLN861B, GLU132A, GLU81A, GLU839B, GLU851B, GLU858B, GLU885B, GLY842B, GLY848B, GLY856B, HIS844B, HIS92A, ILE130A, ILE810B, ILE814B, ILE816B, ILE843B, ILE853B, ILE869B, ILE889B, LEU50A, LEU58A, LEU850B, LEU855B, LEU875B, LEU89A, LEU910B, LYS138A, LYS52A, LYS806B, LYS863B, MET813B, MET857B, MET883B, MET93A, PHE133A, PHE136A, PHE82A, PHE83A, PHE864B, PHE899B, PRO135A, PRO91A, SER84A, SER870B, SER871B, SER88A, SER895B, THR87A, THR892B, TRP817B, TYR79A, TYR808B, TYR90A, TYR94A, TYR98A, VAL54A, VAL835B, VAL841B, VAL845B, VAL846B, VAL849B, VAL859B, VAL884B, VAL888B
• A-D: ALA129A, ARG1005D, ARG111A, ARG113A, ARG998D, ASN1015D, ASP1002D, ASP112A, ASP115A, GLN1001D, GLN104A, GLN137A, GLN999D, GLU1006D, GLU132A, GLU994D, GLU995D, GLY116A, ILE1009D, ILE107A, ILE108A, ILE130A, ILE997D, LEU1008D, LEU109A, LEU50A, PHE110A, PHE114A, PHE133A, PRO135A, TYR117A, VAL1000D, VAL1014D, VAL131A
• B-C: ALA129C, ARG1005B, ARG111C, ARG113C, ARG998B, ASN1015B, ASP1002B, ASP112C, ASP115C, GLN1001B, GLN104C, GLN137C, GLN999B, GLU1006B, GLU132C, GLU994B, GLU995B, GLY116C, ILE1009B, ILE107C, ILE108C, ILE130C, ILE997B, LEU1008B, LEU50C, PHE114C, PHE133C, PRO135C, TYR117C, VAL1000B, VAL1014B, VAL131C
• B-D: ALA887B, ALA887D, ARG1005B, ARG1005D, ARG891B, ARG891D, ARG940B, ARG940D, ARG951B, ARG951D, ASN1015B, ASN1015D, ASN902B, ASN902D, ASP904B, ASP904D, ASP943B, CYS944B, CYS944D, GLU1004B, GLU1004D, GLU1006B, GLU1006D, GLU885B, GLU885D, GLY1012B, GLY1012D, GLY905B, GLY905D, ILE1009B, ILE1009D, ILE889B, ILE889D, LEU1003B, LEU1003D, LEU1008B, LEU1008D, LEU1011B, LEU1011D, LEU1013B, LEU1013D, LEU893B, LEU893D, LEU942B, LEU942D, LYS1010B, LYS1010D, LYS941B, LYS941D, PHE1007B, PHE1007D, PHE890B, PHE890D, PHE945B, PHE945D, PRO903B, PRO903D, SER886B, SER886D, SER895B, SER895D, SER906B, SER906D, SER937B, SER937D, SER938B, SER938D, THR892B, THR892D, TRP955B, TRP955D, TYR894B, TYR894D, TYR948B, TYR948D, VAL1014B, VAL1014D, VAL888B, VAL888D
• C-D: ALA134C, ALA139C, ALA140C, ALA887D, ALA95C, ARG56C, ARG57C, ARG854D, ARG867D, ARG868D, ARG882D, ARG891D, ARG96C, ASN815D, ASN818D, ASN85C, ASN860D, ASN865D, ASP807D, ASP840D, ASP847D, ASP852D, ASP86C, CYS811D, CYS812D, GLN137C, GLN803D, GLN861D, GLU132C, GLU81C, GLU839D, GLU851D, GLU858D, GLU885D, GLY842D, GLY848D, GLY856D, HIS844D, HIS92C, ILE130C, ILE810D, ILE814D, ILE816D, ILE843D, ILE853D, ILE889D, LEU50C, LEU58C, LEU850D, LEU855D, LEU875D, LEU89C, LEU910D, LYS138C, LYS52C, LYS806D, LYS863D, MET813D, MET857D, MET883D, MET93C, PHE133C, PHE136C, PHE82C, PHE83C, PHE864D, PHE899D, PRO135C, PRO91C, SER84C, SER870D, SER871D, SER88C, SER895D, THR87C, THR892D, TRP817D, TYR79C, TYR808D, TYR90C, TYR94C, TYR98C, VAL54C, VAL835D, VAL841D, VAL845D, VAL846D, VAL849D, VAL859D, VAL884D, VAL888D