1UN0

crystal structure of yeast karyopherin (importin) alpha in complex with a nup2p n-terminal fragment

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 122
  • Norm. En. per Res.: -4.3165
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-32.3097	-78.1073	-251.886	-362.3031	133	13	2	10537	8	47	43
A-C	-81.9757	-73.8488	-370.794	-526.6185	122	41	0	14525	9	29	44
A-D	0.0	-5.1707	-9.3827	-14.5533	15	0	0	703	0	6	2
B-C	0.0	-5.8095	-9.4697	-15.2792	14	0	0	671	0	5	2
B-D	-78.8547	-68.5338	-205.271	-352.6595	120	58	0	13890	7	28	44

Interface residues

• A-B: ALA129A, ALA129B, ALA152A, ALA152B, ALA193A, ALA193B, ALA196A, ALA196B, ALA235A, ALA235B, ALA277A, ALA277B, ARG112A, ARG112B, ARG117A, ARG117B, ARG120A, ARG120B, ARG233A, ARG233B, ASN157A, ASN157B, ASN199A, ASN199B, ASN241A, ASN241B, ASP124A, ASP124B, ASP270A, ASP270B, ASP276A, ASP276B, GLN128A, GLN128B, GLN165A, GLN165B, GLN192A, GLN192B, GLN316A, GLN316B, GLU118A, GLU118B, GLU188A, GLU188B, GLU191A, GLU191B, GLU272A, GLU272B, GLU311A, GLU311B, GLU88A, GLU88B, HIS119A, HIS119B, HIS310A, HIS310B, ILE114A, ILE114B, ILE123A, ILE123B, ILE127A, ILE127B, ILE194A, ILE194B, ILE232A, LEU115A, LEU115B, LEU149A, LEU149B, LEU231A, LEU231B, LEU274A, LEU274B, LEU314A, LEU314B, LEU89A, LEU89B, LYS190B, LYS354A, LYS354B, MET269A, PRO121A, PRO121B, PRO122A, PRO122B, PRO229B, PRO353A, PRO353B, PRO90A, PRO90B, SER116A, SER116B, SER160A, SER160B, SER230A, SER230B, SER240A, SER240B, SER312A, SER312B, THR156A, THR156B, THR234A, THR234B, THR236A, THR236B, THR238A, THR238B, THR271A, THR271B, THR273A, THR273B, THR313A, THR313B, TRP153A, TRP153B, TRP195A, TRP195B, TRP237A, TRP237B, TRP279A, TRP279B, VAL125A, VAL125B, VAL126A, VAL126B, VAL168B, VAL189A, VAL189B, VAL275A, VAL275B, VAL315A, VAL315B
• A-C: ALA277A, ALA280A, ALA291A, ALA319A, ALA322A, ALA361A, ALA370A, ALA403A, ALA406A, ALA42C, ALA49C, ARG208A, ARG233A, ARG244A, ARG321A, ARG38C, ARG39C, ARG443A, ARG46C, ARG47C, ASN199A, ASN241A, ASN325A, ASN330A, ASN356A, ASN367A, ASN372A, ASN37C, ASN409A, ASP276A, ASP286A, ASP331A, CYS243A, CYS278A, CYS362A, CYS404A, GLN249A, GLN289A, GLN316A, GLN333A, GLN335A, GLN375A, GLU272A, GLU355A, GLU360A, GLU396A, GLU402A, GLY198A, GLY202A, GLY245A, GLY287A, GLY324A, GLY329A, GLY371A, ILE281A, ILE292A, ILE326A, ILE338A, ILE357A, ILE365A, ILE368A, ILE376A, ILE407A, ILE41C, ILE444A, LEU239A, LEU242A, LEU284A, LEU308A, LEU314A, LEU320A, LEU332A, LEU349A, LYS246A, LYS247A, LYS354A, LYS358A, LYS359A, LYS398A, LYS401A, LYS40C, LYS45C, LYS51C, MET36C, MET43C, MET48C, PHE50C, PRO248A, PRO250A, PRO288A, PRO318A, PRO353A, PRO44C, SER204A, SER240A, SER282A, SER285A, SER366A, SER408A, SER412A, THR205A, THR236A, THR238A, THR273A, THR313A, THR317A, THR328A, THR334A, THR364A, THR369A, THR399A, TRP195A, TRP237A, TRP279A, TRP363A, TRP405A, TYR283A, VAL275A, VAL315A, VAL323A, VAL327A, VAL447A
• A-D: ALA164A, ALA49D, ARG120A, ARG47D, ASP124A, GLN128A, GLN165A, ILE127A, LYS167A, LYS51D, MET48D, PHE50D, SER163A, THR162A, VAL168A
• B-C: ALA164B, ALA49C, ARG120B, ARG47C, ASP124B, GLN128B, GLN165B, LYS167B, LYS51C, MET48C, PHE50C, SER163B, THR162B, VAL168B
• B-D: ALA277B, ALA280B, ALA291B, ALA319B, ALA322B, ALA361B, ALA370B, ALA403B, ALA406B, ALA42D, ALA49D, ARG208B, ARG233B, ARG244B, ARG321B, ARG38D, ARG39D, ARG443B, ARG46D, ARG47D, ASN199B, ASN241B, ASN325B, ASN330B, ASN356B, ASN367B, ASN372B, ASN37D, ASN409B, ASP276B, ASP286B, ASP331B, CYS243B, CYS278B, CYS362B, CYS404B, GLN249B, GLN289B, GLN316B, GLN333B, GLN335B, GLN375B, GLU272B, GLU355B, GLU360B, GLU402B, GLY198B, GLY202B, GLY245B, GLY287B, GLY324B, GLY329B, GLY371B, ILE281B, ILE292B, ILE326B, ILE338B, ILE357B, ILE365B, ILE368B, ILE376B, ILE41D, ILE444B, LEU239B, LEU242B, LEU284B, LEU308B, LEU314B, LEU320B, LEU332B, LEU343B, LEU349B, LYS246B, LYS247B, LYS354B, LYS359B, LYS398B, LYS401B, LYS40D, LYS45D, LYS51D, MET36D, MET43D, MET48D, PHE50D, PRO248B, PRO250B, PRO288B, PRO318B, PRO44D, SER204B, SER240B, SER282B, SER285B, SER366B, SER412B, THR205B, THR236B, THR238B, THR273B, THR313B, THR317B, THR328B, THR334B, THR364B, THR369B, THR399B, TRP195B, TRP237B, TRP279B, TRP363B, TRP405B, TYR283B, VAL275B, VAL315B, VAL323B, VAL327B, VAL337B, VAL379B, VAL447B