1UKL

crystal structure of importin-beta and srebp-2 complex

• Total interactions analyzed: 15
• Total true interactions: 12
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 103
  • Norm. En. per Res.: -4.0482
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	5.7879	-57.9172	-52.1293	108	20	3	4960	0	65	37
A-C	-54.3906	-83.9591	-80.9445	-219.2942	104	24	3	5298	12	62	37
A-D	-26.322	-64.8163	-96.1562	-187.2945	97	10	2	4793	4	67	38
A-E	0.0	0.0	-17.8237	-17.8237	24	0	0	1055	0	12	6
A-F	0.0	0.9705	-0.1333	0.8372	6	0	0	42	0	8	6
B-C	0.0	-5.8009	-20.3029	-26.1038	30	4	0	1375	1	12	6
B-D	0.0	10.6287	-6.3356	4.2931	10	0	0	365	0	6	5
B-E	-48.0754	-41.469	-121.539	-211.0834	106	14	3	6545	9	63	32
B-F	-38.4592	-49.8338	-88.2951	-176.5881	104	12	2	4643	3	70	35
C-D	-26.991	-30.9248	-329.262	-387.1779	99	28	20	15370	3	26	36
D-F	0.0	11.8074	-4.0725	7.7349	10	0	0	256	0	2	5
E-F	-24.5544	-45.8094	-346.605	-416.9688	103	31	21	16504	2	27	45

Interface residues

• A-B: ALA294A, ALA294B, ALA297A, ALA297B, ALA300A, ALA300B, ALA301A, ALA301B, ALA484A, ALA484B, ALA485A, ALA485B, ALA488A, ALA488B, ALA495A, ALA495B, ALA862B, ARG305A, ARG305B, ARG851A, ARG851B, ARG852A, ARG852B, ARG870A, ARG870B, ASN400A, ASN400B, ASN445B, ASN874B, ASP361A, ASP361B, ASP362A, ASP362B, ASP446B, ASP486A, ASP486B, ASP489A, ASP489B, ASP490A, ASP490B, CYS358A, CYS358B, CYS359A, CYS359B, GLN303A, GLN303B, GLN491B, GLU296A, GLU296B, GLU299A, GLU299B, GLU302A, GLU302B, GLU360A, GLU360B, GLU398A, GLU441A, GLU441B, GLU483B, GLU838A, GLU845A, GLU845B, GLU849B, GLY304A, GLY304B, HIS844A, ILE295A, ILE295B, LYS312A, LYS312B, LYS316A, LYS316B, LYS403A, LYS403B, LYS867A, LYS867B, LYS871A, LYS873A, PHE313A, PHE313B, PRO306A, PRO306B, PRO307A, PRO307B, PRO399A, PRO399B, PRO404A, PRO494A, PRO494B, PRO841A, SER298A, SER298B, SER311A, SER311B, THR310A, THR310B, THR496A, THR496B, THR848A, THR848B, THR863A, THR863B, THR866A, THR866B, TYR497A, VAL447B, VAL487A, VAL487B
• A-C: ALA300A, ALA347A, ALA362C, ALA373C, ALA586A, ALA669A, ARG305A, ARG343C, ARG371C, ARG388C, ARG434A, ARG593A, ARG707A, ASN343A, ASN347C, ASN384C, ASN469A, ASN523A, ASN590A, ASN759A, ASP339A, ASP340A, ASP341A, ASP361C, ASP375C, ASP627A, ASP751A, ASP753A, ASP756A, ASP809A, ASP812A, GLN303A, GLN381C, GLN382C, GLN589A, GLN665A, GLU296A, GLU299A, GLU302A, GLU308A, GLU395A, GLU437A, GLU479A, GLU530A, GLU626A, GLU760A, GLU763A, GLU808A, GLU849A, GLY359C, GLY368C, GLY623A, GLY813A, HIS365C, HIS385C, HIS706A, HIS810A, ILE346C, ILE374C, ILE377C, LEU380C, LEU438A, LEU668A, LEU761A, LYS346A, LYS349C, LYS354C, LYS363C, LYS366C, LYS372C, LYS378C, LYS386C, LYS537A, LYS749A, LYS854A, MET353A, MET533A, MET630A, MET754A, PHE752A, PRO306A, PRO307A, SER344C, SER345C, SER476A, SER527A, SER708A, SER750A, SER853A, THR811A, THR855A, TRP342A, TRP430A, TRP472A, TYR376C, TYR379C, TYR664A, TYR757A, VAL350A, VAL357C, VAL383C, VAL666A, VAL755A, VAL814A
• A-D: ALA294A, ALA297A, ALA300A, ALA301A, ALA362D, ALA480A, ARG305A, ARG343D, ARG371D, ARG388D, ARG434A, ASN347D, ASN400A, ASN538A, ASN856A, ASP288A, ASP292A, ASP348D, ASP355D, ASP375D, ASP489A, ASP812A, CYS358A, GLN250A, GLN303A, GLN382D, GLN389D, GLN401A, GLN491A, GLU296A, GLU299A, GLU308A, GLU352D, GLU360A, GLU395A, GLU398A, GLU437A, GLU441A, GLU479A, GLU483A, GLU492A, GLU493A, GLU534A, GLY359D, GLY368D, GLY396A, GLY813A, HIS309A, HIS365D, ILE295A, ILE351D, ILE374D, ILE377D, LEU293A, LEU353D, LEU354A, LEU356D, LEU380D, LEU387D, LEU394A, LEU438A, LEU439A, LYS206A, LYS349D, LYS354D, LYS363D, LYS366D, LYS372D, LYS378D, LYS386D, LYS403A, LYS537A, LYS854A, LYS857A, MET291A, PHE752A, PRO307A, PRO397A, PRO399A, PRO440A, SER298A, SER344D, SER345D, SER367D, SER475A, SER476A, SER750A, THR357A, THR360D, THR855A, TRP472A, TYR376D, TYR379D, TYR482A, VAL357D, VAL369D, VAL383D
• A-E: ALA318A, ASP361A, ASP362A, GLN320A, GLN389E, GLN399E, GLN401A, GLU398A, GLY317A, HIS366A, HIS385E, ILE363A, LEU319A, LEU396E, LYS316A, LYS395E, LYS400E, LYS402E, PRO365A, PRO369A, TYR321A, VAL364A, VAL367A, VAL393E
• A-F: ARG852A, ASP361F, GLU302A, LYS363F, LYS372F, LYS854A
• B-C: ALA397C, ARG388C, ASN398C, ASN400B, ASP361B, ASP362B, GLN320B, GLN389C, GLN399C, GLN401B, GLU398B, GLY317B, HIS366B, HIS385C, ILE363B, LEU319B, LEU368B, LEU396C, LYS316B, LYS386C, LYS395C, LYS400C, PRO324B, PRO365B, PRO369B, TYR321B, VAL323B, VAL364B, VAL367B, VAL393C
• B-D: ALA362D, ARG852B, ASP361D, GLU302B, GLY359D, LYS354D, LYS363D, LYS854B, THR360D, THR848B
• B-E: ALA300B, ALA362E, ALA373E, ALA467B, ALA473B, ALA669B, ARG305B, ARG343E, ARG371E, ARG388E, ARG434B, ARG465B, ARG707B, ASN347E, ASN384E, ASN469B, ASN522B, ASN523B, ASN759B, ASP361E, ASP375E, ASP627B, ASP751B, ASP753B, ASP756B, ASP807B, ASP809B, ASP812B, CYS471B, GLN303B, GLN381E, GLN382E, GLN521B, GLN665B, GLU296B, GLU299B, GLU302B, GLU308B, GLU395B, GLU437B, GLU530B, GLU534B, GLU626B, GLU663B, GLU760B, GLU763B, GLU808B, GLU849B, GLY359E, GLY368E, GLY433B, GLY623B, GLY813B, HIS365E, HIS385E, HIS706B, HIS810B, ILE346E, ILE374E, ILE377E, LEU356E, LEU380E, LEU438B, LEU524B, LEU668B, LYS349E, LYS363E, LYS366E, LYS372E, LYS378E, LYS386E, LYS749B, LYS854B, MET353B, MET388B, MET630B, MET754B, PHE752B, PRO306B, PRO307B, PRO464B, SER344E, SER345E, SER468B, SER475B, SER526B, SER527B, SER531B, SER750B, SER853B, THR811B, THR855B, TRP430B, TRP472B, TYR376E, TYR379E, TYR664B, TYR757B, VAL357E, VAL383E, VAL466B, VAL470B, VAL666B, VAL755B, VAL814B, VAL815B
• B-F: ALA294B, ALA297B, ALA300B, ALA373F, ARG305B, ARG343F, ARG371F, ARG388F, ARG434B, ARG679B, ASN347F, ASN384F, ASN400B, ASN538B, ASP288B, ASP292B, ASP348F, ASP355F, ASP375F, ASP676B, ASP719B, ASP812B, CYS358B, CYS678B, CYS817B, GLN250B, GLN303B, GLN382F, GLN389F, GLN401B, GLN774B, GLU296B, GLU299B, GLU302B, GLU308B, GLU352F, GLU360B, GLU390F, GLU395B, GLU398B, GLU437B, GLU479B, GLU483B, GLU534B, GLU637B, GLU763B, GLU767B, GLY368F, GLY396B, GLY672B, GLY675B, GLY820B, HIS309B, HIS365F, HIS385F, ILE295B, ILE346F, ILE351F, ILE374F, ILE377F, LEU293B, LEU354B, LEU380F, LEU387F, LEU394B, LEU438B, LEU439B, LEU722B, LEU861B, LYS206B, LYS363F, LYS366F, LYS372F, LYS378F, LYS386F, LYS403B, LYS537B, LYS854B, LYS857B, MET291B, MET630B, PRO307B, PRO397B, PRO399B, PRO440B, SER298B, SER344F, SER345F, SER367F, SER476B, SER633B, SER715B, SER750B, THR357B, THR360F, THR770B, THR855B, TRP472B, TYR376F, TYR379F, VAL357F, VAL369F, VAL383F, VAL716B
• C-D: ALA373C, ALA373D, ALA397C, ALA397D, ARG371C, ARG371D, ARG388C, ARG388D, ASN347C, ASN347D, ASN384C, ASN384D, ASN391C, ASN391D, ASN398C, ASN398D, ASN401C, ASN401D, ASP348C, ASP348D, ASP355C, ASP355D, ASP375C, ASP375D, GLN381C, GLN381D, GLN382C, GLN382D, GLN389C, GLN389D, GLN399C, GLN399D, GLU352C, GLU352D, GLU390C, GLU390D, GLY368C, GLY368D, HIS365D, HIS385C, HIS385D, ILE346C, ILE346D, ILE350C, ILE350D, ILE351C, ILE351D, ILE374C, ILE374D, ILE377C, ILE377D, LEU353C, LEU353D, LEU356C, LEU356D, LEU370C, LEU370D, LEU380C, LEU380D, LEU387C, LEU387D, LEU394C, LEU394D, LEU396C, LEU396D, LYS349C, LYS349D, LYS354C, LYS354D, LYS366C, LYS366D, LYS372C, LYS372D, LYS378C, LYS378D, LYS386C, LYS386D, LYS395C, LYS395D, LYS400C, LYS400D, LYS402C, LYS402D, SER344C, SER345C, SER367C, SER367D, TYR376C, TYR376D, TYR379C, TYR379D, VAL357C, VAL357D, VAL369C, VAL369D, VAL383C, VAL383D, VAL393C, VAL393D
• D-F: ALA362D, ASP355D, ASP355F, ASP361D, ASP361F, GLY359D, GLY359F, LEU356F, THR360D, THR360F
• E-F: ALA373E, ALA373F, ALA397E, ALA397F, ARG343E, ARG371E, ARG371F, ARG388E, ARG388F, ASN347E, ASN347F, ASN384E, ASN384F, ASN391E, ASN391F, ASN398E, ASN398F, ASN401E, ASN401F, ASP348E, ASP348F, ASP355E, ASP355F, ASP375E, ASP375F, GLN381E, GLN381F, GLN382E, GLN382F, GLN389E, GLN389F, GLN399E, GLN399F, GLU352E, GLU352F, GLU390E, GLU390F, GLY368E, GLY368F, HIS365F, HIS385E, HIS385F, ILE346E, ILE346F, ILE350E, ILE350F, ILE351E, ILE351F, ILE374E, ILE374F, ILE377E, ILE377F, LEU353E, LEU353F, LEU356E, LEU356F, LEU370E, LEU370F, LEU380E, LEU380F, LEU387E, LEU387F, LEU394E, LEU394F, LEU396E, LEU396F, LEU403E, LEU403F, LYS349E, LYS349F, LYS354E, LYS354F, LYS366E, LYS366F, LYS372E, LYS372F, LYS378E, LYS378F, LYS386E, LYS386F, LYS395E, LYS395F, LYS400E, LYS400F, LYS402E, LYS402F, SER344E, SER345E, SER345F, SER367E, SER367F, TYR376E, TYR376F, TYR379E, TYR379F, VAL357E, VAL357F, VAL369E, VAL369F, VAL383E, VAL383F, VAL393E, VAL393F