1UF2

the atomic structure of rice dwarf virus (rdv)

• Total interactions analyzed: 120
• Total true interactions: 42
• Strongest Interaction:
  • Chains: B-E
  • Int. Res.: 41
  • Norm. En. per Res.: -3.2239
• Hub Node: A(10)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-124.1107	-132.1293	-808.595	-1064.8351	339	35	17	34621	14	80	69
A-P	0.0	0.0	-33.602	-33.602	26	0	0	1497	0	0	0
A-C	0.0	0.0	-23.0861	-23.0861	34	0	0	1383	0	0	1
A-D	-38.0765	0.0	-83.503	-121.5795	56	6	1	3438	0	2	2
A-Q	0.0	0.0	-25.1229	-25.1229	42	0	0	1772	0	3	8
A-E	-46.5886	-21.7006	-134.598	-202.8871	89	10	4	5318	4	13	8
A-S	0.0	-2.3726	-132.827	-135.1996	100	4	4	6858	0	7	11
A-I	0.0	0.0	-55.5512	-55.5512	49	0	2	2802	0	1	3
A-J	0.0	6.5682			2
A-K	-44.7286	-1.9998			8
B-D	-7.2867	11.4399	-67.4939	-63.3407	43	3	0	2793	0	5	4
B-Q	0.0	0.0	-79.3773	-79.3773	45	5	1	3361	0	1	3
B-E	-48.951	0.0	-83.2275	-132.1785	41	6	1	3154	0	0	4
B-F	0.0	9.8936	-84.5339	-74.6403	88	7	0	4835	0	8	11
B-R	-10.9782	-0.3477	-137.303	-148.6289	86	7	2	6191	0	7	11
B-G	-7.836	-11.9805	-32.9131	-52.7296	47	3	1	1938	0	9	3
B-H	-20.6237	-36.0329	-153.1	-209.7566	125	2	9	7396	4	14	12
B-T	0.0	-5.9198			2
P-C	-81.0318	-74.6655	-657.13	-812.8273	253	42	14	28886	11	53	55
P-D	-84.1335	-16.0109	-682.187	-782.3315	254	40	16	29062	10	53	54
C-D	-86.9349	-30.1184	-669.694	-786.7473	253	36	14	29392	8	54	53
C-Q	-6.6988	-10.564	-63.413	-80.6759	81	7	0	3909	1	27	9
C-F	0.0	0.0	-53.8022	-53.8022	91	14	3	3913	0	1	1
D-Q	0.0	0.0	-10.7108	-10.7108	14	1	0	553	0	0	4
D-F	0.0	-7.3655	-57.6473	-65.0127	77	2	0	3295	1	27	8
Q-E	-96.9453	-37.2752	-664.372	-798.5925	255	42	12	29380	11	53	54
Q-F	-90.7251	-45.0786	-666.911	-802.7146	264	56	13	30113	9	54	53
Q-S	-2.5369	-18.2509	-87.5188	-108.3066	80	3	0	4254	1	26	9
Q-J	-4.6709	0.0			2
E-F	-77.4752	-40.6157	-667.348	-785.4389	253	48	13	29629	11	53	53
E-G	-17.2523	-3.0949	-60.4068	-80.7541	69	5	0	3219	2	18	15
E-S	0.0	0.0	-9.7437	-9.7437	14	6	0	620	0	2	5
E-J	-2.1098	-17.4037			9
F-R	-25.8972	-11.1626	-69.5084	-106.5682	73	5	0	3653	3	22	15
F-G	0.0	1.0692	-9.1561	-8.0869	22	0	0	754	0	4	6
R-G	-80.5421	-32.9058	-673.037	-786.4849	252	48	13	29566	11	53	53
R-H	-75.8955	-18.1746	-688.279	-782.3491	255	43	15	29874	9	53	52
G-H	-73.5119	-35.4808	-677.684	-786.6767	254	43	16	29698	10	54	52
H-T	-12.194	-15.4654			11
S-I	-77.0146	-41.6638	-444.827	-563.5054	191	24	12	19308	8	36	34
S-J	-71.8572	-26.3321			38
I-J	-90.0799	-39.6825			40

Interface residues

• A-B: ALA113A, ALA11B, ALA209B, ALA257A, ALA274B, ALA322B, ALA405A, ALA443A, ALA492A, ALA499A, ALA532A, ALA581B, ALA586B, ALA594B, ALA624A, ALA664A, ALA691A, ALA7B, ALA817A, ALA820A, ALA998A, ARG1009B, ARG122A, ARG124A, ARG256A, ARG262B, ARG282A, ARG306A, ARG406A, ARG414A, ARG452A, ARG55A, ARG563B, ARG579B, ARG590B, ARG688A, ARG6B, ARG718A, ARG726A, ARG734A, ARG740A, ARG822A, ARG825A, ARG826A, ARG827A, ARG915A, ASN131A, ASN336B, ASN33B, ASN413A, ASN450A, ASN500A, ASN548B, ASN580B, ASN582B, ASN584B, ASN597B, ASN689A, ASN737A, ASN749A, ASN819A, ASN830A, ASP1011B, ASP1015B, ASP103A, ASP111A, ASP132A, ASP264B, ASP265B, ASP2B, ASP326B, ASP36B, ASP410A, ASP445A, ASP493A, ASP593B, ASP625A, ASP661A, ASP668A, ASP692A, ASP736A, ASP814A, ASP816A, ASP829A, ASP908A, ASP913A, ASP994A, ASP9B, CYS107A, CYS244A, GLN1016B, GLN266B, GLN286A, GLN318B, GLN324B, GLN325B, GLN407A, GLN446A, GLN448A, GLN547B, GLN573B, GLN651B, GLN653B, GLN673A, GLN712A, GLN713A, GLN824A, GLU109A, GLU115A, GLU13B, GLU207B, GLU21B, GLU30B, GLU329B, GLU37B, GLU629A, GLU667A, GLU697A, GLU698A, GLU704A, GLU705A, GLU723A, GLY1004B, GLY1007B, GLY1014B, GLY10B, GLY22B, GLY275B, GLY328B, GLY372A, GLY451A, GLY498A, GLY5B, GLY647B, GLY665A, GLY666A, GLY728A, GLY995A, HIS1006B, HIS110A, HIS121A, HIS245B, HIS25B, HIS633A, HIS695A, HIS910A, ILE1001A, ILE1001B, ILE1003B, ILE126A, ILE276B, ILE34B, ILE41B, ILE444A, ILE578B, ILE58A, ILE626A, ILE628A, ILE648B, ILE654B, ILE669A, ILE671A, ILE693A, ILE706A, ILE715A, LEU1010B, LEU1019B, LEU118A, LEU130A, LEU18B, LEU253A, LEU261A, LEU261B, LEU263A, LEU263B, LEU269B, LEU271A, LEU271B, LEU287A, LEU288A, LEU327B, LEU35B, LEU38B, LEU409A, LEU531A, LEU533A, LEU587B, LEU599B, LEU632A, LEU655B, LEU670A, LEU696A, LEU710A, LEU750A, LEU823A, LEU907A, LYS104A, LYS15B, LYS270B, LYS39B, LYS631A, LYS701A, LYS714A, LYS732A, LYS911A, LYS997A, MET120A, MET129A, MET1B, MET280A, MET317B, MET319B, MET373A, MET725A, PHE105A, PHE14B, PHE260B, PHE646B, PHE662A, PHE663A, PHE694A, PHE730A, PHE815A, PRO1002B, PRO1017B, PRO1018B, PRO116A, PRO208B, PRO246A, PRO258A, PRO281A, PRO283A, PRO28B, PRO57A, PRO596B, PRO59A, PRO627A, PRO650B, PRO660A, PRO690A, PRO733A, PRO748A, PRO916A, PRO917A, SER112A, SER117A, SER128A, SER12B, SER16B, SER24B, SER268B, SER273B, SER332B, SER334B, SER335B, SER3B, SER449A, SER496A, SER51A, SER54A, SER583B, SER589B, SER61A, SER708A, SER724A, SER727A, SER729A, SER731A, SER912A, THR119A, THR20B, THR23B, THR247B, THR272B, THR27B, THR321B, THR338B, THR404A, THR495A, THR4B, THR56A, THR585B, THR831A, THR999A, TRP447A, TRP577B, TRP630A, TRP993A, TYR1000A, TYR114A, TYR127A, TYR133A, TYR243A, TYR250A, TYR250B, TYR252A, TYR26B, TYR290A, TYR32B, TYR371A, TYR497A, TYR652B, TYR751A, TYR833A, TYR8B, TYR914A, VAL1005B, VAL1008B, VAL125A, VAL17B, VAL19B, VAL210B, VAL248A, VAL249A, VAL267A, VAL267B, VAL284A, VAL285A, VAL29B, VAL316B, VAL31B, VAL320B, VAL323B, VAL330B, VAL331B, VAL333B, VAL337B, VAL52A, VAL53A, VAL616A, VAL649B, VAL659A, VAL699A, VAL702A, VAL707A, VAL709A, VAL711A, VAL828A, VAL996A
• A-P: ALA38P, ALA434A, ARG431A, ASN37P, ASN41P, ASN435A, ASN460A, ASN461A, ASP35P, GLN436A, GLU466A, GLY30P, GLY34P, GLY465A, LEU31P, LEU432A, LEU462A, LEU463A, PHE28P, PHE36P, PRO464A, SER29P, SER40P, THR32P, THR33P, VAL437A
• A-C: ALA38C, ALA485A, ALA486A, ARG105C, ARG503A, ASN37C, ASN41C, ASN480A, ASP35C, GLN1016A, GLN109C, GLN474A, GLN483A, GLN484A, GLU466A, GLU487A, GLY34C, GLY465A, ILE488A, LEU31C, LEU463A, LEU467A, MET112C, MET1C, MET517A, PHE36C, PRO111C, PRO464A, THR101C, THR32C, THR33C, THR470A, THR481A, VAL110C
• A-D: ALA38D, ALA457A, ALA482A, ALA486A, ARG452A, ASN37D, ASN41D, ASN435A, ASN460A, ASN461A, ASN480A, ASN500A, ASP26D, ASP35D, ASP56D, CYS23D, GLN109D, GLN436A, GLN45D, GLN474A, GLN483A, GLN484A, GLU487A, GLU501A, GLY30D, GLY34D, GLY479A, ILE458A, ILE488A, ILE490A, LEU31D, LEU39D, LEU462A, LEU463A, LEU489A, MET42D, PHE28D, PHE36D, PHE43D, PRO464A, PRO491A, SER29D, SER40D, SER55D, THR27D, THR32D, THR33D, THR44D, THR470A, THR481A, THR502A, TYR459A, VAL437A, VAL456A, VAL48D, VAL54D
• A-Q: ALA51Q, ALA744A, ARG105Q, ARG107Q, ARG676A, ARG688A, ARG740A, ARG741A, ARG746A, ASN41Q, ASN684A, ASN689A, ASN737A, ASP736A, GLN109Q, GLN45Q, GLN745A, GLY52Q, GLY687A, LEU46Q, LEU686A, LEU739A, LYS92Q, MET112Q, MET1Q, MET295A, PHE738A, PRO106Q, PRO111Q, PRO742A, SER40Q, SER47Q, SER49Q, SER50Q, SER683A, THR101Q, THR102Q, THR44Q, TYR53Q, VAL110Q, VAL48Q, VAL743A
• A-E: ALA113A, ALA38E, ALA51E, ALA813A, ALA817A, ALA869A, ARG105E, ARG676A, ARG688A, ARG740A, ARG875A, ARG915A, ASN37E, ASN41E, ASN684A, ASN689A, ASN873A, ASP111A, ASP56E, ASP680A, ASP692A, ASP776A, ASP814A, ASP816A, ASP97E, ASP98E, CYS777A, GLN824A, GLU115A, GLY30E, GLY34E, GLY52E, GLY687A, HIS810A, ILE100E, ILE693A, ILE812A, ILE870A, LEU31E, LEU39E, LEU686A, LEU739A, LEU821A, LYS685A, LYS807A, LYS871A, LYS92E, MET1E, MET840A, MET874A, PHE36E, PHE43E, PHE694A, PHE815A, PHE99E, PRO116A, PRO690A, PRO742A, PRO916A, SER112A, SER117A, SER29E, SER40E, SER47E, SER49E, SER50E, SER55E, SER683A, SER96E, THR101E, THR102E, THR119A, THR32E, THR33E, THR44E, THR811A, THR94E, TYR103E, TYR114A, TYR53E, TYR679A, TYR779A, VAL48E, VAL54E, VAL743A, VAL808A, VAL809A, VAL872A, VAL95E
• A-S: ALA197A, ALA214A, ALA230A, ALA233A, ALA38S, ALA51S, ARG105S, ARG219A, ARG967A, ARG976A, ASN37S, ASN41S, ASN763A, ASN962A, ASN977A, ASP237A, ASP35S, ASP56S, ASP759A, ASP965A, ASP982A, ASP98S, GLN109S, GLN226A, GLN45S, GLN757A, GLN767A, GLU971A, GLU974A, GLY30S, GLY34S, GLY52S, GLY793A, GLY981A, HIS225A, HIS232A, HIS760A, HIS770A, ILE188A, ILE201A, ILE227A, ILE771A, LEU229A, LEU231A, LEU234A, LEU31S, LEU71A, LEU768A, LEU975A, LYS193A, LYS92S, MET112S, MET1S, MET5S, MET765A, PHE189A, PHE28S, PHE36S, PHE72A, PHE93A, PHE972A, PHE978A, PHE979A, PRO106S, PRO111S, PRO196A, PRO60S, PRO794A, SER29S, SER40S, SER47S, SER49S, SER50S, SER55S, SER973A, THR101S, THR102S, THR32S, THR33S, THR44S, THR766A, THR769A, THR92A, THR966A, THR970A, THR980A, TYR53S, TYR764A, TYR802A, TYR969A, TYR97A, VAL110S, VAL198A, VAL48S, VAL54S, VAL59S, VAL761A, VAL795A, VAL95A, VAL968A
• A-I: ALA38I, ARG184A, ARG219A, ARG976A, ASN181A, ASN37I, ASN41I, ASN977A, ASP35I, ASP56I, ASP982A, GLN109I, GLN191A, GLN226A, GLN45I, GLU150A, GLU185A, GLU88A, GLU971A, GLU974A, GLY149A, GLY30I, GLY34I, GLY981A, ILE188A, LEU151A, LEU31I, LYS193A, PHE189A, PHE28I, PHE36I, PHE972A, PHE978A, PRO196A, SER221A, SER29I, SER40I, SER49I, SER50I, SER55I, SER973A, THR32I, THR33I, THR44I, THR980A, TYR53I, VAL148A, VAL153A, VAL54I
• A-J: ARG866A, LYS92J
• A-K: ASP294K, GLU296K, HIS314A, LEU313A, LEU315A, LYS295K, MET317A, PHE292K
• B-D: ALA424B, ALA427B, ALA430B, ARG431B, ARG77D, ASN471B, ASP76D, ASP97D, ASP98D, CYS78D, GLN426B, GLN573B, GLU466B, GLY465B, GLY569B, GLY79D, ILE100D, LEU462B, LEU463B, LEU467B, LEU469B, MET1D, MET67D, PHE570B, PHE71D, PHE99D, PRO464B, PRO93D, SER49D, SER70D, SER74D, SER96D, THR101D, THR102D, THR425B, THR428B, THR429B, THR470B, THR75D, THR94D, VAL468B, VAL571B, VAL95D
• B-Q: ALA38Q, ALA51Q, ARG478B, ARG556B, ASN1013B, ASN37Q, ASN41Q, ASN554B, ASP1011B, ASP1015B, ASP35Q, GLN1016B, GLN45Q, GLU545B, GLU553B, GLY1014B, GLY30Q, GLY34Q, GLY52Q, GLY546B, HIS557B, ILE550B, ILE552B, LEU1019B, LEU31Q, LEU39Q, MET42Q, PHE28Q, PHE36Q, PHE43Q, PHE511B, PRO1012B, PRO1017B, PRO1018B, SER29Q, SER40Q, SER549B, SER551B, SER55Q, THR32Q, THR33Q, THR44Q, THR543B, TYR53Q, VAL54Q
• B-E: ALA38E, ALA51E, ARG1009B, ARG105E, ASN1013B, ASN33B, ASN37E, ASN41E, ASP1011B, ASP1015B, ASP35E, GLN1016B, GLN45E, GLN547B, GLY1007B, GLY1014B, GLY30E, GLY34E, GLY52E, HIS1006B, ILE34B, LEU1010B, LEU31E, LEU39E, MET42E, PHE36E, PHE43E, PRO1012B, PRO1017B, PRO1018B, SER40E, SER49E, THR32E, THR33E, THR44E, TYR53E, VAL1005B, VAL1008B, VAL31B, VAL48E, VAL54E
• B-F: ALA38F, ALA482B, ALA485B, ALA513B, ALA519B, ALA522B, ARG1009B, ARG105F, ARG478B, ARG503B, ARG529B, ARG556B, ASN1013B, ASN37F, ASN41F, ASN460B, ASN461B, ASN471B, ASN480B, ASP1011B, ASP35F, ASP56F, ASP97F, ASP98F, GLN109F, GLN45F, GLN474B, GLN483B, GLN484B, GLN547B, GLU487B, GLU545B, GLU553B, GLY1014B, GLY30F, GLY34F, GLY479B, GLY546B, ILE100F, ILE104F, ILE458B, ILE473B, LEU1010B, LEU31F, LEU462B, LEU463B, LEU489B, LEU540B, LYS92F, MET1F, MET517B, MET5F, PHE36F, PHE511B, PHE99F, PRO1012B, PRO106F, PRO464B, PRO514B, PRO520B, PRO93F, SER29F, SER2F, SER40F, SER47F, SER525B, SER549B, SER551B, SER55F, SER96F, THR101F, THR102F, THR32F, THR33F, THR44F, THR470B, THR481B, THR526B, THR543B, THR91F, THR94F, TYR103F, TYR459B, VAL1008B, VAL110F, VAL544B, VAL54F, VAL95F
• B-R: ALA38R, ALA51R, ALA691B, ALA744B, ARG105R, ARG503B, ARG676B, ARG688B, ARG740B, ARG741B, ASN37R, ASN41R, ASN500B, ASN516B, ASN684B, ASN689B, ASN737B, ASN763B, ASP493B, ASP56R, ASP680B, ASP692B, ASP736B, ASP759B, GLN45R, GLN494B, GLN767B, GLU487B, GLY30R, GLY52R, GLY687B, HIS760B, HIS770B, ILE104R, ILE488B, ILE490B, ILE693B, LEU31R, LEU46R, LEU489B, LEU682B, LEU686B, LEU696B, LEU739B, LYS685B, LYS732B, LYS92R, MET1R, MET42R, MET517B, MET5R, PHE28R, PHE36R, PHE43R, PHE738B, PRO106R, PRO491B, PRO57R, PRO690B, PRO742B, PRO93R, SER29R, SER40R, SER47R, SER49R, SER50R, SER55R, SER683B, SER96R, THR101R, THR32R, THR33R, THR44R, THR681B, THR766B, THR91R, THR94R, TRP735B, TYR53R, TYR679B, TYR762B, TYR764B, VAL48R, VAL54R, VAL743B, VAL95R
• B-G: ALA197B, ALA532B, ALA744B, ARG105G, ARG107G, ARG211B, ARG529B, ARG741B, ARG746B, ASN37G, ASN41G, ASP204B, ASP205B, ASP530B, ASP535B, ASP56G, GLN109G, GLN45G, GLN745B, GLY203B, GLY30G, GLY34G, ILE201B, LEU31G, LEU747B, LYS92G, MET112G, PHE202B, PRO106G, PRO111G, PRO208B, PRO742B, SER113G, SER255B, SER29G, SER55G, SER752B, THR32G, THR33G, THR44G, TYR252B, TYR53G, VAL110G, VAL198B, VAL48G, VAL54G, VAL743B
• B-H: ALA197B, ALA230B, ALA233B, ALA235B, ALA38H, ALA51H, ARG105H, ARG107H, ARG219B, ARG282B, ARG688B, ARG746B, ARG967B, ASN236B, ASN37H, ASN41H, ASN684B, ASN689B, ASN763B, ASN804B, ASN962B, ASP204B, ASP205B, ASP237B, ASP56H, ASP759B, ASP776B, ASP965B, ASP97H, ASP98H, CYS777B, GLN109H, GLN226B, GLN45H, GLN757B, GLN767B, GLU228B, GLU803B, GLY203B, GLY30H, GLY34H, GLY52H, GLY687B, HIS225B, HIS232B, HIS760B, HIS770B, ILE201B, ILE227B, ILE241B, ILE771B, ILE774B, LEU12H, LEU229B, LEU231B, LEU234B, LEU238B, LEU31H, LEU46H, LEU686B, LEU71B, LEU768B, LYS685B, LYS871B, LYS92H, MET112H, MET1H, MET42H, MET5H, MET67H, MET765B, PHE202B, PHE28H, PHE36H, PHE43H, PHE978B, PHE99H, PRO106H, PRO111H, PRO199B, PRO60H, PRO93H, PRO960B, SER240B, SER29H, SER40H, SER47H, SER49H, SER50H, SER55H, SER683B, SER96H, THR101H, THR102H, THR119B, THR32H, THR44H, THR63H, THR756B, THR766B, THR769B, THR775B, THR91H, THR94H, THR966B, TYR53H, TYR762B, TYR764B, TYR779B, TYR802B, TYR969B, TYR97B, VAL110H, VAL198B, VAL200B, VAL48H, VAL54H, VAL59H, VAL761B, VAL805B, VAL95H, VAL963B, VAL964B, VAL983B, VAL984B
• B-T: ARG105T, GLU971B
• P-C: ALA11P, ALA128C, ALA128P, ALA15C, ALA15P, ALA174C, ALA187C, ALA223P, ALA237C, ALA241P, ALA243P, ALA245P, ALA246P, ALA258P, ALA292P, ALA301P, ALA338C, ALA38P, ALA412C, ARG107P, ARG117P, ARG135C, ARG158C, ARG189C, ARG190C, ARG190P, ARG191P, ARG197C, ARG22C, ARG22P, ARG268P, ARG337C, ARG378C, ARG382C, ARG384C, ARG416C, ARG419C, ARG58C, ASN120P, ASN121P, ASN137P, ASN166C, ASN229C, ASN229P, ASN24C, ASN259P, ASN260P, ASN302P, ASN37P, ASN41P, ASP114P, ASP257P, ASP266P, ASP26C, ASP321C, ASP322C, ASP324C, ASP327C, ASP35C, ASP35P, ASP56C, ASP8P, CYS154C, CYS23C, GLN109P, GLN118P, GLN125P, GLN136C, GLN163C, GLN264P, GLN335C, GLN45P, GLN62C, GLU134P, GLU149P, GLU14C, GLU14P, GLU152C, GLU188C, GLU188P, GLU18C, GLU18P, GLU294P, GLU296P, GLU343C, GLU381C, GLY165C, GLY171C, GLY222P, GLY233C, GLY233P, GLY25C, GLY274P, GLY295P, GLY30C, GLY34C, GLY34P, GLY415C, ILE167C, ILE16C, ILE16P, ILE172C, ILE235C, ILE235P, ILE236C, ILE236P, ILE293P, ILE299P, ILE320C, ILE411C, LEU108P, LEU119P, LEU122P, LEU124P, LEU12P, LEU132C, LEU13C, LEU13P, LEU156C, LEU173C, LEU193P, LEU261P, LEU269P, LEU300P, LEU31C, LEU329C, LEU333C, LEU336C, LEU39C, LEU39P, LEU410C, LEU61C, LEU7P, LYS129C, LYS131C, LYS131P, LYS155C, LYS286P, MET112P, MET169C, MET170C, MET42P, PHE157C, PHE227P, PHE231C, PHE231P, PHE232C, PHE232P, PHE252P, PHE271P, PHE28C, PHE297P, PHE323C, PHE328C, PHE332C, PHE36C, PHE372C, PHE377C, PHE379C, PHE414C, PHE43C, PHE43P, PRO106P, PRO111P, PRO126P, PRO130C, PRO130P, PRO146P, PRO150P, PRO153C, PRO168C, PRO176C, PRO255P, PRO262P, PRO375C, PRO57C, PRO60C, SER10C, SER10P, SER113P, SER123P, SER127C, SER127P, SER148P, SER159C, SER17C, SER219P, SER230C, SER230P, SER267P, SER270P, SER272P, SER29C, SER319C, SER326C, SER334C, SER346C, SER374C, SER380C, SER409C, SER40C, SER40P, SER55C, SER65C, THR115P, THR164C, THR175C, THR221P, THR228P, THR234C, THR234P, THR240P, THR242P, THR244P, THR251P, THR253P, THR256P, THR265P, THR27C, THR298P, THR318C, THR32C, THR330C, THR331C, THR33C, THR373C, THR44P, THR9P, TRP376C, TYR133C, TYR133P, TYR147P, TYR19C, TYR19P, TYR224P, TYR226P, TYR307C, TYR342C, TYR417C, TYR418C, VAL110P, VAL116P, VAL186C, VAL20C, VAL21C, VAL220P, VAL225P, VAL239P, VAL254P, VAL263P, VAL325C, VAL413C, VAL59C
• P-D: ALA11D, ALA128D, ALA128P, ALA15D, ALA15P, ALA174P, ALA187P, ALA223D, ALA237P, ALA241D, ALA243D, ALA245D, ALA246D, ALA258D, ALA292D, ALA301D, ALA338P, ALA383P, ALA38D, ALA412P, ARG105D, ARG107D, ARG117D, ARG135P, ARG158P, ARG189P, ARG190D, ARG190P, ARG191D, ARG197P, ARG22D, ARG22P, ARG268D, ARG337P, ARG378P, ARG382P, ARG384P, ARG416P, ARG419P, ARG58P, ASN120D, ASN121D, ASN137D, ASN166P, ASN229D, ASN229P, ASN24P, ASN259D, ASN260D, ASN302D, ASN37D, ASN41D, ASP114D, ASP257D, ASP266D, ASP26P, ASP321P, ASP322P, ASP324P, ASP327P, ASP35D, ASP35P, ASP56P, ASP8D, CYS154P, CYS23P, GLN109D, GLN118D, GLN125D, GLN136P, GLN163P, GLN264D, GLN335P, GLN45D, GLN62P, GLU134D, GLU149D, GLU14D, GLU14P, GLU152P, GLU188D, GLU188P, GLU18D, GLU18P, GLU294D, GLU296D, GLU343P, GLU381P, GLY165P, GLY171P, GLY222D, GLY233D, GLY233P, GLY25P, GLY274D, GLY275D, GLY295D, GLY30P, GLY34D, GLY34P, GLY415P, ILE167P, ILE16D, ILE16P, ILE172P, ILE235D, ILE235P, ILE236D, ILE236P, ILE293D, ILE299D, ILE320P, ILE411P, LEU108D, LEU119D, LEU122D, LEU124D, LEU12D, LEU132P, LEU13D, LEU13P, LEU156P, LEU173P, LEU193D, LEU261D, LEU269D, LEU300D, LEU31P, LEU329P, LEU333P, LEU39D, LEU39P, LEU46D, LEU61P, LEU7D, LYS129P, LYS131D, LYS131P, LYS155P, LYS286D, MET112D, MET169P, MET170P, MET42D, PHE157P, PHE227D, PHE231D, PHE231P, PHE232D, PHE232P, PHE252D, PHE271D, PHE28P, PHE297D, PHE323P, PHE328P, PHE332P, PHE36P, PHE372P, PHE377P, PHE379P, PHE414P, PHE43D, PHE43P, PRO106D, PRO111D, PRO126D, PRO130P, PRO146D, PRO150D, PRO153P, PRO168P, PRO176P, PRO255D, PRO262D, PRO375P, PRO57P, PRO60P, SER10D, SER10P, SER113D, SER123D, SER127D, SER127P, SER148D, SER159P, SER17P, SER219D, SER230D, SER230P, SER267D, SER270D, SER272D, SER29P, SER319P, SER326P, SER334P, SER346P, SER374P, SER380P, SER409P, SER40D, SER40P, SER55P, SER65P, THR115D, THR164P, THR175P, THR221D, THR228D, THR234D, THR234P, THR240D, THR242D, THR244D, THR251D, THR253D, THR256D, THR265D, THR27P, THR298D, THR318P, THR32P, THR330P, THR331P, THR33D, THR33P, THR373P, THR385P, THR44D, THR9D, TRP376P, TYR133D, TYR133P, TYR147D, TYR19D, TYR19P, TYR224D, TYR226D, TYR307P, TYR342P, TYR417P, TYR418P, VAL110D, VAL116D, VAL20P, VAL21P, VAL220D, VAL225D, VAL254D, VAL263D, VAL325P, VAL413P, VAL59P
• C-D: ALA11C, ALA11D, ALA128C, ALA15C, ALA15D, ALA174D, ALA187D, ALA223C, ALA237D, ALA241C, ALA243C, ALA245C, ALA246C, ALA258C, ALA292C, ALA301C, ALA338D, ALA38C, ALA412D, ARG105C, ARG107C, ARG117C, ARG135D, ARG158D, ARG189D, ARG190C, ARG190D, ARG191C, ARG197D, ARG22C, ARG22D, ARG268C, ARG337D, ARG378D, ARG382D, ARG384D, ARG416D, ARG419D, ARG58D, ASN120C, ASN121C, ASN137C, ASN166D, ASN229C, ASN229D, ASN24D, ASN259C, ASN260C, ASN302C, ASN37C, ASN41C, ASP114C, ASP257C, ASP266C, ASP26D, ASP321D, ASP322D, ASP324D, ASP327D, ASP35C, ASP35D, ASP56D, ASP8C, CYS154D, CYS23D, CYS290C, GLN109C, GLN118C, GLN125C, GLN136D, GLN264C, GLN335D, GLN45C, GLN62D, GLU134C, GLU134D, GLU149C, GLU14C, GLU14D, GLU152D, GLU188C, GLU188D, GLU18C, GLU18D, GLU294C, GLU296C, GLU343D, GLU381D, GLY165D, GLY171D, GLY222C, GLY233C, GLY233D, GLY25D, GLY295C, GLY30D, GLY34C, GLY34D, GLY415D, ILE167D, ILE16C, ILE16D, ILE172D, ILE235C, ILE235D, ILE236C, ILE236D, ILE293C, ILE299C, ILE320D, ILE411D, LEU108C, LEU119C, LEU122C, LEU124C, LEU12C, LEU132D, LEU13C, LEU13D, LEU156D, LEU173D, LEU193C, LEU261C, LEU269C, LEU300C, LEU31D, LEU329D, LEU333D, LEU39C, LEU39D, LEU410D, LEU61D, LEU7C, LYS129D, LYS131C, LYS131D, LYS155D, LYS286C, MET112C, MET169D, MET170D, MET42C, PHE157D, PHE227C, PHE231C, PHE231D, PHE232C, PHE232D, PHE252C, PHE271C, PHE28D, PHE297C, PHE323D, PHE328D, PHE332D, PHE36D, PHE372D, PHE377D, PHE379D, PHE414D, PHE43C, PHE43D, PRO106C, PRO111C, PRO126C, PRO130D, PRO146C, PRO150C, PRO153D, PRO168D, PRO176D, PRO255C, PRO262C, PRO375D, PRO57D, PRO60D, SER10C, SER10D, SER113C, SER123C, SER127C, SER127D, SER148C, SER159D, SER17D, SER219C, SER230C, SER230D, SER267C, SER270C, SER272C, SER29D, SER319D, SER326D, SER334D, SER346D, SER374D, SER380D, SER409D, SER40C, SER40D, SER55D, SER65D, THR115C, THR164D, THR175D, THR221C, THR228C, THR234C, THR234D, THR240C, THR242C, THR244C, THR251C, THR253C, THR256C, THR265C, THR27D, THR298C, THR318D, THR32D, THR330D, THR331D, THR33C, THR33D, THR373D, THR44C, THR9C, TRP376D, TYR133C, TYR133D, TYR147C, TYR19C, TYR19D, TYR224C, TYR226C, TYR307D, TYR342D, TYR417D, TYR418D, VAL110C, VAL116C, VAL20D, VAL21D, VAL220C, VAL225C, VAL239C, VAL254C, VAL263C, VAL325D, VAL413D, VAL54D, VAL59D
• C-Q: ALA138C, ALA301C, ALA306C, ALA338Q, ALA348Q, ALA365Q, ALA371Q, ARG117C, ARG303C, ARG337Q, ARG382Q, ARG3C, ARG402C, ARG77Q, ASN137C, ASN302C, ASN311C, ASN354Q, ASN395C, ASN421Q, ASN88C, ASP114C, ASP144C, ASP347Q, ASP350Q, ASP362C, ASP393C, ASP76Q, ASP90C, CYS339Q, GLN118C, GLN305C, GLN341Q, GLN351Q, GLU343Q, GLY142C, GLY340Q, ILE139C, ILE344Q, ILE366Q, ILE396C, LEU143C, LEU310C, LEU336Q, LEU370Q, LEU394C, LEU399C, LYS141C, LYS398C, LYS84C, MET140C, PHE345Q, PHE372Q, PHE87C, PRO111C, PRO363C, PRO364C, PRO364Q, PRO367Q, PRO375Q, PRO420Q, SER304C, SER312C, SER346Q, SER374Q, SER70Q, SER74Q, SER89C, THR115C, THR309C, THR358Q, THR73Q, THR75Q, THR85C, THR91C, TRP376Q, TYR147C, TYR307C, TYR308C, TYR342Q, TYR360C
• C-F: ALA161C, ALA161F, ALA206C, ALA206F, ALA213C, ALA213F, ALA258C, ALA258F, ALA306F, ARG303C, ARG303F, ASN259C, ASN259F, ASN260C, ASN260F, ASN277C, ASN277F, ASN279C, ASN279F, ASN302C, ASN302F, ASN311C, ASN311F, ASN395C, ASN395F, ASP257C, ASP257F, GLN163C, GLN163F, GLN182C, GLN182F, GLN208C, GLN208F, GLN315C, GLN315F, GLU281C, GLU281F, GLY162C, GLY162F, GLY205F, GLY274C, GLY274F, GLY275C, GLY275F, GLY276C, GLY276F, ILE278C, ILE278F, ILE313C, ILE313F, LEU273C, LEU273F, LEU280F, LEU310C, LEU394C, LEU394F, LYS398C, LYS398F, PHE185F, PHE209C, PHE209F, PRO183C, PRO183F, PRO212C, PRO212F, PRO255C, PRO255F, SER216C, SER216F, SER272F, SER312C, SER312F, THR253C, THR253F, THR256C, THR256F, THR314C, THR314F, TRP214C, TRP214F, TYR207C, TYR207F, VAL160C, VAL160F, VAL210C, VAL210F, VAL211C, VAL211F, VAL217C, VAL254C, VAL254F
• D-Q: ALA338D, ALA338Q, ARG419D, ARG419Q, ARG58D, ARG58Q, ASN421D, ASN421Q, ASP56D, ASP56Q, GLN62D, GLN62Q, PRO420D, PRO420Q
• D-F: ALA138F, ALA306F, ALA338D, ALA348D, ALA365D, ALA368D, ALA371D, ARG117F, ARG303F, ARG337D, ARG382D, ARG3F, ARG402F, ARG419D, ASN137F, ASN302F, ASN311F, ASN354D, ASN395F, ASN421D, ASN88F, ASP114F, ASP144F, ASP347D, ASP350D, ASP362F, ASP393F, ASP76D, ASP90F, CYS339D, GLN118F, GLN305F, GLN341D, GLN351D, GLU343D, GLY142F, GLY340D, ILE139F, ILE344D, ILE366D, ILE396F, LEU143F, LEU310F, LEU336D, LEU370D, LEU394F, LEU399F, LYS141F, LYS398F, LYS84F, LYS92F, MET140F, MET361F, PHE372D, PHE87F, PRO111F, PRO363F, PRO375D, PRO420D, SER304F, SER312F, SER346D, SER374D, SER70D, SER74D, SER89F, THR115F, THR309F, THR73D, THR75D, THR85F, THR91F, TRP376D, TYR307F, TYR308F, TYR342D, TYR360F
• Q-E: ALA11Q, ALA128Q, ALA15E, ALA15Q, ALA174E, ALA187E, ALA223Q, ALA241Q, ALA243Q, ALA245Q, ALA246Q, ALA258Q, ALA292Q, ALA301Q, ALA338E, ALA383E, ALA38Q, ALA412E, ARG105Q, ARG107Q, ARG117Q, ARG135E, ARG158E, ARG189E, ARG190E, ARG190Q, ARG191Q, ARG197E, ARG22E, ARG22Q, ARG268Q, ARG337E, ARG378E, ARG382E, ARG384E, ARG416E, ARG419E, ARG58E, ASN120Q, ASN121Q, ASN137Q, ASN166E, ASN229E, ASN229Q, ASN24E, ASN259Q, ASN260Q, ASN302Q, ASN37Q, ASN41Q, ASP114Q, ASP247Q, ASP257Q, ASP266Q, ASP26E, ASP321E, ASP322E, ASP324E, ASP327E, ASP350E, ASP35E, ASP35Q, ASP56E, ASP8Q, CYS154E, CYS23E, GLN109Q, GLN118Q, GLN125Q, GLN264Q, GLN335E, GLN45Q, GLN62E, GLU134Q, GLU149Q, GLU14E, GLU14Q, GLU152E, GLU188E, GLU188Q, GLU18E, GLU18Q, GLU294Q, GLU296Q, GLU343E, GLU381E, GLY165E, GLY171E, GLY222Q, GLY233E, GLY233Q, GLY25E, GLY274Q, GLY295Q, GLY30E, GLY34E, GLY34Q, GLY415E, ILE167E, ILE16E, ILE16Q, ILE172E, ILE235E, ILE235Q, ILE236E, ILE236Q, ILE293Q, ILE299Q, ILE320E, ILE411E, LEU108Q, LEU119Q, LEU122Q, LEU124Q, LEU12Q, LEU132E, LEU13E, LEU13Q, LEU156E, LEU173E, LEU193Q, LEU261Q, LEU269Q, LEU300Q, LEU31E, LEU329E, LEU333E, LEU336E, LEU39E, LEU39Q, LEU410E, LEU61E, LEU7Q, LYS129E, LYS129Q, LYS131E, LYS131Q, LYS155E, LYS286Q, MET112Q, MET169E, MET170E, MET42Q, PHE157E, PHE227Q, PHE231E, PHE231Q, PHE232E, PHE232Q, PHE252Q, PHE271Q, PHE28E, PHE297Q, PHE323E, PHE328E, PHE332E, PHE36E, PHE372E, PHE377E, PHE379E, PHE414E, PHE43E, PHE43Q, PRO106Q, PRO111Q, PRO126Q, PRO130E, PRO130Q, PRO146Q, PRO150Q, PRO153E, PRO168E, PRO176E, PRO255Q, PRO262Q, PRO375E, PRO57E, PRO60E, SER10E, SER10Q, SER113Q, SER123Q, SER127E, SER127Q, SER148Q, SER159E, SER17E, SER219Q, SER230E, SER230Q, SER267Q, SER270Q, SER272Q, SER29E, SER319E, SER326E, SER334E, SER346E, SER374E, SER380E, SER409E, SER40E, SER40Q, SER55E, SER65E, THR115Q, THR164E, THR175E, THR221Q, THR228Q, THR234E, THR234Q, THR240Q, THR242Q, THR244Q, THR251Q, THR253Q, THR256Q, THR265Q, THR27E, THR298Q, THR318E, THR32E, THR330E, THR331E, THR33E, THR33Q, THR373E, THR44Q, THR9Q, TRP376E, TYR133E, TYR133Q, TYR147Q, TYR19E, TYR19Q, TYR224Q, TYR226Q, TYR307E, TYR342E, TYR417E, TYR418E, VAL110Q, VAL116Q, VAL186E, VAL20E, VAL21E, VAL220Q, VAL225Q, VAL254Q, VAL263Q, VAL325E, VAL413E, VAL54E, VAL59E
• Q-F: ALA11F, ALA11Q, ALA128F, ALA128Q, ALA15F, ALA15Q, ALA174Q, ALA187Q, ALA223F, ALA237Q, ALA241F, ALA243F, ALA245F, ALA246F, ALA258F, ALA292F, ALA301F, ALA338Q, ALA383Q, ALA38F, ALA412Q, ARG105F, ARG107F, ARG117F, ARG135Q, ARG158Q, ARG189Q, ARG190F, ARG190Q, ARG191F, ARG197Q, ARG22F, ARG22Q, ARG268F, ARG337Q, ARG378Q, ARG382Q, ARG384Q, ARG416Q, ARG419Q, ARG58Q, ASN120F, ASN121F, ASN137F, ASN166Q, ASN229F, ASN229Q, ASN24Q, ASN259F, ASN260F, ASN302F, ASN37F, ASN37Q, ASN41F, ASP114F, ASP257F, ASP266F, ASP26Q, ASP321Q, ASP322Q, ASP324Q, ASP327Q, ASP35F, ASP35Q, ASP56Q, ASP8F, CYS154Q, CYS23Q, CYS290F, GLN109F, GLN118F, GLN125F, GLN264F, GLN335Q, GLN45F, GLN62Q, GLU134F, GLU149F, GLU14F, GLU14Q, GLU152Q, GLU188F, GLU188Q, GLU18F, GLU18Q, GLU294F, GLU296F, GLU343Q, GLU381Q, GLY165Q, GLY171Q, GLY222F, GLY233F, GLY233Q, GLY25Q, GLY274F, GLY275F, GLY295F, GLY30Q, GLY34F, GLY34Q, GLY415Q, ILE151Q, ILE167Q, ILE16F, ILE16Q, ILE172Q, ILE235F, ILE235Q, ILE236F, ILE236Q, ILE293F, ILE299F, ILE320Q, ILE411Q, LEU108F, LEU119F, LEU122F, LEU124F, LEU12F, LEU132Q, LEU13F, LEU13Q, LEU156Q, LEU173Q, LEU193F, LEU218F, LEU261F, LEU269F, LEU273F, LEU300F, LEU31Q, LEU329Q, LEU333Q, LEU336Q, LEU39F, LEU39Q, LEU46F, LEU61Q, LEU7F, LYS129Q, LYS131F, LYS131Q, LYS155Q, LYS286F, MET112F, MET169Q, MET170Q, MET42F, PHE157Q, PHE227F, PHE231F, PHE231Q, PHE232F, PHE232Q, PHE252F, PHE271F, PHE28Q, PHE297F, PHE323Q, PHE328Q, PHE332Q, PHE36Q, PHE372Q, PHE377Q, PHE379Q, PHE414Q, PHE43F, PHE43Q, PRO106F, PRO111F, PRO126F, PRO130F, PRO130Q, PRO146F, PRO150F, PRO153Q, PRO168Q, PRO176Q, PRO255F, PRO262F, PRO375Q, PRO57Q, PRO60Q, SER10F, SER10Q, SER113F, SER123F, SER127F, SER127Q, SER148F, SER159Q, SER17Q, SER219F, SER230F, SER230Q, SER267F, SER270F, SER272F, SER29Q, SER319Q, SER326Q, SER334Q, SER346Q, SER374Q, SER380Q, SER409Q, SER40F, SER40Q, SER55Q, SER65Q, THR115F, THR164Q, THR175Q, THR221F, THR228F, THR234F, THR234Q, THR240F, THR242F, THR244F, THR251F, THR253F, THR256F, THR265F, THR27Q, THR298F, THR318Q, THR32Q, THR330Q, THR331Q, THR33Q, THR373Q, THR385Q, THR44F, THR9F, TRP376Q, TYR133F, TYR133Q, TYR147F, TYR19F, TYR19Q, TYR224F, TYR226F, TYR307Q, TYR342Q, TYR417Q, TYR418Q, TYR53Q, VAL110F, VAL116F, VAL186Q, VAL20Q, VAL21Q, VAL220F, VAL225F, VAL239F, VAL254F, VAL263F, VAL291F, VAL325Q, VAL413Q, VAL54Q, VAL59Q
• Q-S: ALA138Q, ALA301Q, ALA306Q, ALA338S, ALA348S, ALA365S, ALA368S, ALA371S, ARG117Q, ARG303Q, ARG337S, ARG382S, ARG3Q, ARG402Q, ARG77S, ASN121Q, ASN137Q, ASN302Q, ASN311Q, ASN354S, ASN395Q, ASN421S, ASN88Q, ASP114Q, ASP144Q, ASP347S, ASP350S, ASP362Q, ASP393Q, ASP76S, ASP90Q, CYS339S, GLN118Q, GLN305Q, GLN341S, GLN351S, GLU343S, GLY142Q, GLY340S, ILE139Q, ILE344S, ILE366S, ILE396Q, LEU143Q, LEU310Q, LEU336S, LEU370S, LEU399Q, LYS141Q, LYS398Q, LYS84Q, MET140Q, MET361Q, PHE345S, PHE372S, PHE87Q, PRO363Q, PRO364Q, PRO364S, PRO375S, PRO420S, SER304Q, SER346S, SER355S, SER374S, SER70S, SER74S, SER89Q, THR115Q, THR309Q, THR358S, THR73S, THR75S, THR85Q, THR91Q, TYR147Q, TYR307Q, TYR308Q, TYR342S, TYR360Q
• Q-J: ASN277J, GLY276Q
• E-F: ALA11E, ALA11F, ALA128E, ALA128F, ALA15E, ALA15F, ALA174F, ALA187F, ALA223E, ALA237F, ALA241E, ALA243E, ALA245E, ALA246E, ALA258E, ALA292E, ALA301E, ALA338F, ALA383F, ALA38E, ALA412F, ARG107E, ARG117E, ARG135F, ARG158F, ARG189F, ARG190E, ARG190F, ARG191E, ARG197F, ARG22E, ARG22F, ARG268E, ARG337F, ARG378F, ARG382F, ARG384F, ARG416F, ARG419F, ARG58F, ASN120E, ASN121E, ASN137E, ASN166F, ASN229E, ASN229F, ASN24F, ASN259E, ASN260E, ASN302E, ASN37E, ASN41E, ASP114E, ASP257E, ASP266E, ASP26F, ASP321F, ASP322F, ASP324F, ASP327F, ASP35E, ASP35F, ASP56F, ASP8E, CYS154F, CYS23F, CYS290E, GLN109E, GLN118E, GLN125E, GLN264E, GLN335F, GLN45E, GLN62F, GLU134E, GLU149E, GLU14E, GLU14F, GLU152F, GLU188E, GLU188F, GLU18E, GLU18F, GLU294E, GLU296E, GLU343F, GLU381F, GLY165F, GLY171F, GLY222E, GLY233E, GLY233F, GLY25F, GLY295E, GLY30F, GLY34E, GLY34F, GLY415F, ILE167F, ILE16E, ILE16F, ILE172F, ILE235E, ILE235F, ILE236E, ILE236F, ILE293E, ILE299E, ILE320F, ILE411F, LEU108E, LEU119E, LEU122E, LEU124E, LEU12E, LEU132F, LEU13E, LEU13F, LEU156F, LEU173F, LEU193E, LEU261E, LEU269E, LEU300E, LEU31F, LEU329F, LEU333F, LEU39E, LEU39F, LEU410F, LEU46E, LEU61F, LEU7E, LYS129F, LYS131E, LYS131F, LYS155F, LYS286E, MET112E, MET169F, MET170F, MET42E, PHE157F, PHE227E, PHE231E, PHE231F, PHE232E, PHE232F, PHE252E, PHE271E, PHE28F, PHE297E, PHE323F, PHE328F, PHE332F, PHE36F, PHE372F, PHE377F, PHE379F, PHE414F, PHE43E, PHE43F, PRO106E, PRO111E, PRO126E, PRO130E, PRO130F, PRO146E, PRO150E, PRO153F, PRO168F, PRO176F, PRO255E, PRO262E, PRO375F, PRO57F, PRO60F, SER10E, SER10F, SER113E, SER123E, SER127E, SER127F, SER148E, SER159F, SER17F, SER219E, SER230E, SER230F, SER267E, SER270E, SER272E, SER29F, SER319F, SER326F, SER334F, SER374F, SER380F, SER409F, SER40E, SER40F, SER55F, SER65F, THR115E, THR164F, THR175F, THR221E, THR228E, THR234E, THR234F, THR240E, THR242E, THR244E, THR251E, THR253E, THR256E, THR265E, THR27F, THR298E, THR318F, THR32F, THR330F, THR331F, THR33F, THR373F, THR385F, THR44E, THR9E, TYR133E, TYR133F, TYR147E, TYR19E, TYR19F, TYR224E, TYR226E, TYR307F, TYR342F, TYR417F, TYR418F, VAL110E, VAL116E, VAL20F, VAL21F, VAL220E, VAL225E, VAL239E, VAL254E, VAL263E, VAL325F, VAL413F, VAL48E, VAL54F, VAL59F
• E-G: ALA301E, ALA306E, ALA338G, ARG117E, ARG303E, ARG337G, ARG3E, ARG402E, ARG419G, ARG77G, ASN121E, ASN302E, ASN311E, ASN395E, ASN421G, ASN66G, ASN88E, ASP114E, ASP144E, ASP347G, ASP393E, ASP76G, ASP90E, ASP97G, ASP98G, CYS339G, GLN118E, GLN305E, GLN341G, GLN351G, GLN62G, GLU343G, GLY142E, GLY340G, ILE344G, ILE396E, LEU119E, LEU122E, LEU143E, LEU394E, LEU399E, LYS141E, LYS398E, LYS84E, LYS92E, MET67G, PHE345G, PHE71G, PHE99G, PRO111E, PRO420G, SER70G, SER74G, SER89E, SER96G, THR115E, THR309E, THR63G, THR73G, THR75G, THR85E, THR91E, TYR147E, TYR342G, TYR360E, TYR418G, TYR53G, VAL110E, VAL59G
• E-S: ALA338E, ALA338S, ARG419E, ARG419S, ARG58E, ARG58S, ASN421E, ASN421S, ASP56S, GLN335E, GLN62E, GLN62S, PRO420E, PRO420S
• E-J: ARG303J, ARG337E, ARG402J, ASN421E, ASP347E, ASP76E, ASP90J, GLN118J, LYS398J
• F-R: ALA301R, ALA306R, ALA338F, ALA348F, ARG117R, ARG303R, ARG337F, ARG3R, ARG402R, ARG419F, ARG77F, ASN121R, ASN302R, ASN311R, ASN395R, ASN421F, ASN66F, ASN88R, ASP114R, ASP144R, ASP347F, ASP350F, ASP393R, ASP76F, ASP90R, ASP97F, ASP98F, CYS339F, CYS78F, GLN118R, GLN305R, GLN341F, GLN351F, GLN62F, GLU343F, GLY142R, GLY340F, ILE145R, ILE344F, ILE396R, LEU119R, LEU122R, LEU143R, LEU336F, LEU394R, LEU399R, LYS141R, LYS398R, LYS84R, LYS92R, MET67F, PHE345F, PHE71F, PHE99F, PRO111R, PRO420F, SER304R, SER70F, SER74F, SER89R, SER96F, THR115R, THR309R, THR63F, THR73F, THR75F, THR85R, THR91R, TYR147R, TYR342F, TYR360R, TYR418F, VAL59F
• F-G: ALA338F, ALA338G, ARG419F, ARG419G, ARG58F, ARG58G, ASN421F, ASN421G, ASP56F, ASP56G, CYS339F, CYS339G, GLN335G, GLN62F, GLN62G, PRO420G, SER55F, SER55G, TYR418G, TYR53G, VAL59F, VAL59G
• R-G: ALA11R, ALA128G, ALA128R, ALA15G, ALA15R, ALA174G, ALA187G, ALA223R, ALA237G, ALA241R, ALA243R, ALA245R, ALA246R, ALA258R, ALA292R, ALA301R, ALA338G, ALA383G, ALA38R, ALA412G, ARG107R, ARG117R, ARG135G, ARG158G, ARG189G, ARG190G, ARG190R, ARG191R, ARG197G, ARG22G, ARG22R, ARG268R, ARG337G, ARG378G, ARG382G, ARG384G, ARG416G, ARG419G, ARG58G, ASN120R, ASN121R, ASN137R, ASN166G, ASN229G, ASN229R, ASN24G, ASN259R, ASN260R, ASN302R, ASN37R, ASN41R, ASP114R, ASP247R, ASP257R, ASP266R, ASP26G, ASP321G, ASP322G, ASP324G, ASP327G, ASP35G, ASP35R, ASP56G, ASP8R, CYS154G, CYS23G, GLN109R, GLN118R, GLN125R, GLN264R, GLN335G, GLN45R, GLN62G, GLU134R, GLU149R, GLU14G, GLU14R, GLU152G, GLU188G, GLU188R, GLU18G, GLU18R, GLU294R, GLU296R, GLU343G, GLU381G, GLY165G, GLY171G, GLY222R, GLY233G, GLY233R, GLY25G, GLY274R, GLY275R, GLY295R, GLY30G, GLY34G, GLY34R, GLY415G, ILE151G, ILE167G, ILE16G, ILE16R, ILE172G, ILE235G, ILE235R, ILE236G, ILE236R, ILE293R, ILE299R, ILE320G, ILE411G, LEU108R, LEU119R, LEU122R, LEU124R, LEU12R, LEU132G, LEU13G, LEU13R, LEU156G, LEU173G, LEU193R, LEU261R, LEU269R, LEU300R, LEU31G, LEU329G, LEU333G, LEU39G, LEU39R, LEU61G, LEU7R, LYS129G, LYS129R, LYS131G, LYS131R, LYS155G, LYS286R, MET112R, MET169G, MET170G, MET42R, PHE157G, PHE227R, PHE231G, PHE231R, PHE232G, PHE232R, PHE252R, PHE271R, PHE28G, PHE297R, PHE323G, PHE328G, PHE332G, PHE36G, PHE372G, PHE377G, PHE379G, PHE414G, PHE43G, PHE43R, PRO106R, PRO111R, PRO126R, PRO130G, PRO146R, PRO150R, PRO153G, PRO168G, PRO176G, PRO255R, PRO262R, PRO375G, PRO57G, PRO60G, SER10G, SER10R, SER113R, SER123R, SER127G, SER127R, SER148R, SER159G, SER17G, SER219R, SER230G, SER230R, SER267R, SER270R, SER272R, SER29G, SER319G, SER326G, SER334G, SER346G, SER374G, SER380G, SER409G, SER40G, SER40R, SER55G, SER65G, THR115R, THR164G, THR175G, THR221R, THR228R, THR234G, THR234R, THR240R, THR242R, THR244R, THR251R, THR253R, THR256R, THR265R, THR27G, THR298R, THR318G, THR32G, THR330G, THR331G, THR33G, THR373G, THR9R, TYR133G, TYR133R, TYR147R, TYR19G, TYR19R, TYR224R, TYR226R, TYR307G, TYR342G, TYR417G, TYR418G, TYR53G, VAL110R, VAL116R, VAL186G, VAL20G, VAL21G, VAL220R, VAL225R, VAL254R, VAL263R, VAL325G, VAL413G, VAL54G, VAL59G
• R-H: ALA11H, ALA11R, ALA128H, ALA128R, ALA15H, ALA15R, ALA174R, ALA187R, ALA223H, ALA237R, ALA241H, ALA243H, ALA245H, ALA246H, ALA258H, ALA292H, ALA301H, ALA338R, ALA383R, ALA38H, ALA412R, ARG107H, ARG117H, ARG135R, ARG158R, ARG189R, ARG190H, ARG190R, ARG191H, ARG197R, ARG22H, ARG22R, ARG268H, ARG337R, ARG378R, ARG382R, ARG384R, ARG416R, ARG419R, ARG58R, ASN120H, ASN121H, ASN137H, ASN166R, ASN229H, ASN229R, ASN24R, ASN259H, ASN260H, ASN302H, ASN37H, ASN41H, ASP114H, ASP257H, ASP266H, ASP26R, ASP321R, ASP322R, ASP324R, ASP327R, ASP350R, ASP35H, ASP35R, ASP56R, ASP8H, CYS154R, CYS23R, GLN109H, GLN118H, GLN125H, GLN264H, GLN335R, GLN45H, GLN62R, GLU134H, GLU149H, GLU14H, GLU14R, GLU152R, GLU188H, GLU188R, GLU18H, GLU18R, GLU294H, GLU296H, GLU343R, GLU381R, GLY165R, GLY171R, GLY222H, GLY233H, GLY233R, GLY25R, GLY295H, GLY30R, GLY34H, GLY34R, GLY415R, ILE167R, ILE16H, ILE16R, ILE172R, ILE235H, ILE235R, ILE236H, ILE236R, ILE293H, ILE299H, ILE320R, ILE411R, LEU108H, LEU119H, LEU122H, LEU124H, LEU12H, LEU132R, LEU13H, LEU13R, LEU156R, LEU173R, LEU193H, LEU261H, LEU269H, LEU300H, LEU31R, LEU329R, LEU333R, LEU39H, LEU39R, LEU410R, LEU46H, LEU61R, LEU7H, LYS129R, LYS131H, LYS131R, LYS155R, LYS286H, MET112H, MET169R, MET170R, MET42H, PHE157R, PHE227H, PHE231H, PHE231R, PHE232H, PHE232R, PHE252H, PHE271H, PHE28R, PHE297H, PHE323R, PHE328R, PHE332R, PHE36R, PHE372R, PHE377R, PHE379R, PHE414R, PHE43H, PHE43R, PRO106H, PRO111H, PRO126H, PRO130H, PRO130R, PRO146H, PRO150H, PRO153R, PRO168R, PRO176R, PRO255H, PRO262H, PRO375R, PRO57R, PRO60R, SER10H, SER10R, SER113H, SER123H, SER127H, SER127R, SER148H, SER159R, SER17R, SER219H, SER230H, SER230R, SER267H, SER270H, SER272H, SER29R, SER319R, SER326R, SER334R, SER346R, SER374R, SER380R, SER409R, SER40H, SER40R, SER55R, SER65R, THR115H, THR164R, THR175R, THR221H, THR228H, THR234H, THR234R, THR240H, THR242H, THR244H, THR251H, THR253H, THR256H, THR265H, THR27R, THR298H, THR318R, THR32R, THR330R, THR331R, THR33R, THR373R, THR385R, THR44H, THR9H, TRP376R, TYR133H, TYR133R, TYR147H, TYR19H, TYR19R, TYR224H, TYR226H, TYR307R, TYR342R, TYR417R, TYR418R, TYR53R, VAL110H, VAL116H, VAL20R, VAL21R, VAL220H, VAL225H, VAL239H, VAL254H, VAL263H, VAL325R, VAL413R, VAL54R, VAL59R
• G-H: ALA11G, ALA128G, ALA128H, ALA15G, ALA15H, ALA174H, ALA187H, ALA223G, ALA237H, ALA241G, ALA243G, ALA245G, ALA246G, ALA258G, ALA292G, ALA301G, ALA338H, ALA383H, ALA38G, ALA412H, ARG105G, ARG107G, ARG117G, ARG135H, ARG158H, ARG189H, ARG190G, ARG190H, ARG191G, ARG22G, ARG22H, ARG268G, ARG337H, ARG378H, ARG382H, ARG384H, ARG416H, ARG419H, ARG58H, ASN120G, ASN121G, ASN137G, ASN166H, ASN229G, ASN229H, ASN24H, ASN259G, ASN260G, ASN302G, ASN37G, ASN41G, ASP114G, ASP247G, ASP257G, ASP266G, ASP26H, ASP321H, ASP322H, ASP324H, ASP327H, ASP35G, ASP35H, ASP56H, ASP8G, CYS154H, CYS23H, CYS290G, GLN109G, GLN118G, GLN125G, GLN163H, GLN264G, GLN335H, GLN45G, GLN62H, GLU134G, GLU149G, GLU14G, GLU14H, GLU152H, GLU188G, GLU188H, GLU18G, GLU18H, GLU294G, GLU296G, GLU343H, GLU381H, GLY165H, GLY171H, GLY222G, GLY233G, GLY233H, GLY25H, GLY295G, GLY30H, GLY34G, GLY34H, GLY415H, GLY52H, ILE167H, ILE16G, ILE16H, ILE172H, ILE235G, ILE235H, ILE236G, ILE236H, ILE293G, ILE299G, ILE320H, ILE411H, LEU108G, LEU119G, LEU122G, LEU124G, LEU12G, LEU132H, LEU13G, LEU13H, LEU156H, LEU173H, LEU193G, LEU261G, LEU269G, LEU300G, LEU31H, LEU329H, LEU333H, LEU336H, LEU39G, LEU39H, LEU410H, LEU61H, LEU7G, LYS129G, LYS129H, LYS131G, LYS131H, LYS155H, LYS286G, MET112G, MET169H, MET170H, MET42G, PHE157H, PHE227G, PHE231G, PHE231H, PHE232H, PHE252G, PHE271G, PHE28H, PHE297G, PHE323H, PHE328H, PHE332H, PHE36H, PHE372H, PHE377H, PHE379H, PHE414H, PHE43G, PHE43H, PRO106G, PRO111G, PRO126G, PRO130H, PRO146G, PRO150G, PRO153H, PRO168H, PRO176H, PRO255G, PRO262G, PRO375H, PRO57H, PRO60H, SER10G, SER10H, SER113G, SER123G, SER127G, SER127H, SER148G, SER159H, SER17H, SER219G, SER230G, SER230H, SER267G, SER270G, SER272G, SER29H, SER319H, SER326H, SER334H, SER374H, SER380H, SER409H, SER40G, SER40H, SER55H, SER65H, THR115G, THR164H, THR175H, THR221G, THR228G, THR234G, THR234H, THR240G, THR242G, THR244G, THR251G, THR253G, THR256G, THR265G, THR27H, THR298G, THR318H, THR32H, THR330H, THR331H, THR33H, THR373H, THR44G, THR9G, TYR133G, TYR133H, TYR147G, TYR19G, TYR19H, TYR224G, TYR226G, TYR307H, TYR342H, TYR417H, TYR418H, TYR53H, VAL110G, VAL116G, VAL186H, VAL20H, VAL21H, VAL220G, VAL225G, VAL239G, VAL254G, VAL263G, VAL325H, VAL413H, VAL54H, VAL59H
• H-T: ARG303T, ARG337H, ARG402T, ASN421H, ASP347H, ASP76H, ASP90T, GLN118T, GLN341H, GLY142T, LYS398T
• S-I: ALA11I, ALA11S, ALA128I, ALA128S, ALA15I, ALA15S, ALA174I, ALA187I, ALA223S, ALA237I, ALA237S, ALA241S, ALA243S, ALA245S, ALA246S, ALA292S, ALA38S, ARG105S, ARG107S, ARG117S, ARG135I, ARG158I, ARG189I, ARG190I, ARG190S, ARG191S, ARG197I, ARG22I, ARG22S, ARG268S, ARG378I, ARG384I, ARG58I, ASN120S, ASN121S, ASN137S, ASN166I, ASN229I, ASN229S, ASN24I, ASN260S, ASN37I, ASN37S, ASN41S, ASP114S, ASP247S, ASP257S, ASP266S, ASP26I, ASP321I, ASP322I, ASP324I, ASP327I, ASP35I, ASP35S, ASP56I, ASP8S, CYS154I, CYS23I, GLN109S, GLN118S, GLN125S, GLN264S, GLN45S, GLN62I, GLU134S, GLU14I, GLU14S, GLU152I, GLU188I, GLU188S, GLU18I, GLU18S, GLU294S, GLU296S, GLY165I, GLY171I, GLY222S, GLY233I, GLY233S, GLY25I, GLY295S, GLY30I, GLY34I, GLY34S, ILE167I, ILE16I, ILE16S, ILE172I, ILE235I, ILE235S, ILE236I, ILE236S, ILE293S, LEU108S, LEU119S, LEU122S, LEU124S, LEU12S, LEU132I, LEU13I, LEU13S, LEU156I, LEU173I, LEU193S, LEU31I, LEU39I, LEU39S, LEU46S, LEU61I, LEU7S, LYS129I, LYS131I, LYS131S, LYS155I, LYS286S, MET112S, MET169I, MET170I, MET42S, PHE157I, PHE227S, PHE231I, PHE231S, PHE232I, PHE232S, PHE28I, PHE297S, PHE36I, PHE43I, PHE43S, PRO106S, PRO111S, PRO126S, PRO130I, PRO146S, PRO150S, PRO153I, PRO168I, PRO176I, PRO57I, PRO60I, SER10I, SER10S, SER113S, SER123S, SER127I, SER127S, SER159I, SER17I, SER230I, SER230S, SER267S, SER29I, SER40I, SER40S, SER55I, SER65I, THR115S, THR164I, THR175I, THR221S, THR228S, THR234I, THR234S, THR240S, THR242S, THR244S, THR265S, THR27I, THR32I, THR33I, THR44S, THR9S, TYR133I, TYR133S, TYR19I, TYR19S, TYR224S, TYR226S, TYR53I, VAL110S, VAL116S, VAL20I, VAL21I, VAL220S, VAL225S, VAL239S, VAL263S, VAL54I, VAL59I
• S-J: ARG107J, ARG158S, ARG189S, ARG190J, ARG22J, ARG22S, ARG268J, ARG337S, ARG378S, ARG384S, ASN120J, ASN166S, ASN229J, ASN24S, ASP257J, ASP266J, ASP26S, ASP321S, ASP322S, ASP324S, ASP327S, ASP35J, ASP35S, GLN109J, GLN125J, GLU14J, GLU188S, GLU18J, GLU294J, GLU296J, ILE167S, ILE235S, LYS129S, LYS131J, LYS155S, SER29S, THR256J, THR27S
• I-J: ALA243I, ARG107I, ARG158J, ARG189J, ARG190I, ARG191I, ARG22I, ARG22J, ARG268I, ARG378J, ARG384J, ARG58J, ASN166J, ASN229I, ASP257I, ASP266I, ASP26J, ASP321J, ASP322J, ASP324J, ASP327J, ASP35I, ASP35J, GLN118I, GLN125I, GLU14I, GLU188J, GLU18I, GLU294I, GLU296I, GLY171J, ILE167J, ILE235J, LYS129J, LYS131I, LYS155J, PHE232J, SER29J, SER319J, TYR19I