1UDU

crystal structure of human phosphodiesterase 5 complexed with tadalafil(cialis)

• Total interactions analyzed: 1
• Total true interactions: 1
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 87
  • Norm. En. per Res.: -1.8818
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-8.5036	-50.124	-105.093	-163.7206	87	29	3	6552	3	67	76

Interface residues

• A-B: ALA726A, ALA726B, ARG607A, ARG607B, ARG658A, ARG658B, ARG731A, ARG731B, ARG792A, ARG792B, ARG794A, ARG794B, ASN661A, ASN661B, ASN662A, ASN662B, ASN798A, ASN798B, ASP656A, ASP656B, ASP687A, ASP687B, CYS677A, CYS677B, GLN688A, GLN688B, GLN718A, GLN718B, GLN789A, GLN789B, GLU682A, GLU682B, GLU753A, GLU753B, GLU793A, GLU793B, GLU796A, GLU796B, HIS657A, HIS657B, HIS678A, HIS678B, HIS683A, HIS683B, HIS684A, HIS684B, HIS750A, ILE680A, ILE680B, ILE715A, ILE715B, ILE799A, ILE799B, LEU713A, LEU713B, LEU721A, LEU721B, LEU727A, LEU727B, LEU797A, LEU797B, LYS710A, LYS710B, LYS714A, LYS714B, LYS717A, LYS717B, LYS730A, LYS730B, LYS795A, LYS795B, MET681A, MET681B, MET691A, MET691B, PHE686A, PHE686B, SER663A, SER663B, SER679A, SER679B, TYR664A, TYR664B, TYR676A, TYR676B, VAL660A, VAL660B