1TZN

crystal structure of the anthrax toxin protective antigen heptameric prepore bound to the vwa domain of cmg2, an anthrax toxin receptor

• Total interactions analyzed: 378
• Total true interactions: 28
• Strongest Interaction:
  • Chains: H-h
  • Int. Res.: 96
  • Norm. En. per Res.: -3.1854
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-a	-38.6008	-40.5806	-220.911	-300.0925	97	21	6	9211	1	34	37
A-B	-36.1515	-56.9447	-317.872	-410.9682	218	68	3	19934	5	87	63
A-F	-62.6365	-72.3907	-360.288	-495.3153	211	52	3	19468	5	89	60
B-b	-38.288	-40.5706	-221.023	-299.8815	96	20	6	9183	1	34	37
B-C	-34.2792	-76.6613	-339.81	-450.7506	205	59	2	18639	3	85	60
C-c	-39.7514	-40.5772	-221.711	-302.0396	96	21	6	9185	1	34	37
C-O	-33.9319	-72.3232			31
D-d	-41.6809	-40.5772	-220.022	-302.2801	96	22	6	9218	1	34	37
D-E	-48.8108	-73.0209	-374.755	-496.5868	209	41	3	18843	4	87	60
D-O	-75.8438	-63.4519			35
E-e	-42.1391	-40.5714	-221.406	-304.1165	97	22	6	9249	1	34	37
E-F	-38.9799	-76.6181	-361.709	-477.307	209	43	2	18905	4	90	60
F-f	-38.2289	-40.5772	-221.167	-299.9731	97	22	6	9237	1	34	37
G-g	-41.9722	-40.5823	-219.526	-302.0804	96	22	6	9256	1	34	37
G-H	-61.1875	-68.9351	-319.014	-449.1366	216	90	2	20787	7	91	63
G-M	-49.7106	-85.7375			31
H-h	-46.5518	-40.5753	-218.674	-305.8011	96	22	6	9269	1	34	37
H-I	-42.7346	-84.2892	-322.61	-449.6338	214	88	1	19498	7	84	63
I-i	-42.0289	-40.5785			21
I-J	-41.1091	-76.966			31
J-j	-40.6724	-40.5807			21
J-K	-38.8328	-81.954			29
K-k	-37.0238	-40.5702			21
K-L	-49.6983	-73.7127			33
L-l	-37.6114	-40.579			22
L-M	-43.9731	-53.6949			31
M-m	-38.8271	-40.5703			21
O-o	-39.6957	-40.5713			21

Interface residues

• A-a: ALA1056a, ALA1089a, ALA341A, ALA347A, ARG1111a, ARG287A, ARG344A, ARG659A, ASN1057a, ASN1058a, ASN657A, ASN682A, ASN691A, ASN719A, ASP1050a, ASP1148a, ASP1152a, ASP648A, ASP658A, ASP661A, ASP683A, ASP715A, GLN1088a, GLU1117a, GLU1122a, GLU1162a, GLU343A, GLU348A, GLU645A, GLU650A, GLU654A, GLY1053a, GLY1116a, GLY1153a, GLY342A, GLY651A, GLY714A, HIS1121a, ILE1060a, ILE289A, ILE646A, ILE656A, ILE689A, LEU1151a, LEU1154a, LEU1179a, LEU338A, LEU340A, LEU652A, LEU685A, LEU687A, LYS1051a, LYS1110a, LYS1125a, LYS1150a, LYS1161a, LYS653A, LYS679A, LYS680A, LYS684A, MET350A, MET662A, PHE678A, PRO1114a, PRO1156a, PRO686A, SER1052a, SER1054a, SER1086a, SER1087a, SER1113a, SER1157a, SER339A, SER690A, SER717A, THR1090a, THR1118a, THR286A, THR345A, THR349A, THR649A, THR716A, THR718A, TRP1059a, TRP346A, TYR1119a, TYR1158a, TYR660A, TYR681A, TYR688A, TYR694A, VAL1055a, VAL1112a, VAL1115a, VAL1155a, VAL644A, VAL655A
• A-B: ALA307A, ALA311A, ALA392A, ALA406B, ALA417B, ALA420B, ALA423B, ALA460B, ALA585A, ARG178A, ARG200B, ARG242B, ARG252B, ARG365B, ARG449A, ARG468B, ARG470B, ARG490A, ARG503B, ARG636B, ARG669B, ASN180A, ASN198B, ASN246B, ASN268B, ASN292B, ASN306A, ASN326A, ASN328A, ASN363B, ASN376B, ASN388A, ASN399B, ASN408B, ASN409B, ASN415B, ASN435A, ASN437A, ASN463B, ASN466B, ASN476A, ASN499B, ASN509A, ASP179A, ASP181A, ASP185A, ASP195B, ASP231A, ASP244B, ASP265B, ASP283B, ASP315A, ASP451A, ASP453A, ASP472A, ASP472B, ASP497B, ASP512A, ASP520A, ASP634B, ASP671B, ASP677B, GLN285B, GLN389A, GLN400B, GLN403B, GLN424B, GLN454A, GLN483A, GLN485A, GLN543B, GLN670B, GLU188A, GLU190A, GLU224A, GLU237A, GLU237B, GLU250B, GLU267B, GLU302A, GLU308A, GLU465B, GLU479A, GLU486A, GLU515A, GLY241B, GLY305A, GLY317A, GLY318A, GLY323A, GLY467B, GLY474A, GLY495B, GLY672B, HIS304A, HIS310A, ILE243B, ILE316A, ILE404B, ILE459A, ILE484A, ILE665B, LEU187A, LEU203B, LEU216B, LEU391A, LEU401B, LEU416B, LEU481A, LEU498B, LEU514A, LEU628B, LEU668B, LYS197B, LYS199B, LYS220A, LYS225A, LYS238B, LYS245B, LYS387A, LYS395A, LYS414B, LYS496B, LYS518A, LYS586A, LYS633B, LYS637B, LYS673B, LYS680B, LYS703B, MET521A, PHE202B, PHE236B, PHE313A, PHE314A, PHE324A, PHE464B, PHE675B, PRO176A, PRO184A, PRO223A, PRO232A, PRO249B, PRO373B, PRO407B, PRO418B, PRO482A, PRO510A, PRO513A, PRO519A, SER186A, SER221A, SER222A, SER227A, SER230A, SER234A, SER248B, SER294B, SER296B, SER312A, SER319A, SER321A, SER325A, SER327A, SER329A, SER382A, SER402B, SER413B, SER475A, SER478A, SER511A, SER666B, SER667B, THR193B, THR201B, THR240B, THR293B, THR295B, THR300A, THR354A, THR380A, THR390A, THR393A, THR452A, THR461A, THR461B, THR487A, THR516A, THR517A, THR674B, TRP226A, TRP477A, TYR219B, TYR233A, TYR375B, TYR410B, TYR411B, TYR456A, TYR462A, TYR462B, TYR542B, VAL189A, VAL194B, VAL196B, VAL239B, VAL247B, VAL303A, VAL309A, VAL320A, VAL367B, VAL377A, VAL384A, VAL455A, VAL469B, VAL471B, VAL480A, VAL501B, VAL508A
• A-F: ALA307F, ALA311F, ALA406A, ALA417A, ALA423A, ALA460A, ARG178F, ARG200A, ARG242A, ARG252A, ARG365A, ARG449F, ARG468A, ARG470A, ARG490F, ARG503A, ARG636A, ARG669A, ASN180F, ASN198A, ASN246A, ASN268A, ASN292A, ASN306F, ASN326F, ASN328F, ASN363A, ASN376A, ASN388F, ASN399A, ASN408A, ASN409A, ASN415A, ASN437F, ASN463A, ASN466A, ASN476F, ASN499A, ASN509F, ASP177F, ASP179F, ASP181F, ASP185F, ASP195A, ASP231F, ASP244A, ASP265A, ASP315F, ASP451F, ASP453F, ASP472A, ASP472F, ASP497A, ASP512F, ASP520F, ASP634A, ASP671A, ASP677A, GLN285A, GLN389F, GLN400A, GLN403A, GLN424A, GLN454F, GLN483F, GLN485F, GLN543A, GLN670A, GLU188F, GLU190F, GLU224F, GLU237A, GLU237F, GLU267A, GLU302F, GLU308F, GLU465A, GLU479F, GLU486F, GLU515F, GLY241A, GLY305F, GLY317F, GLY318F, GLY323F, GLY467A, GLY474F, GLY495A, GLY672A, HIS304F, HIS310F, ILE243A, ILE316F, ILE404A, ILE459F, ILE484F, ILE665A, LEU187F, LEU203A, LEU216A, LEU401A, LEU416A, LEU481F, LEU498A, LEU514F, LEU628A, LEU668A, LYS197A, LYS199A, LYS220F, LYS225F, LYS238A, LYS245A, LYS387F, LYS395F, LYS414A, LYS496A, LYS518F, LYS586F, LYS633A, LYS637A, LYS673A, LYS680A, LYS703A, PHE202A, PHE236A, PHE313F, PHE314F, PHE324F, PHE464A, PHE675A, PRO176F, PRO184F, PRO223F, PRO232F, PRO249A, PRO373A, PRO407A, PRO418A, PRO482F, PRO510F, PRO513F, PRO519F, SER186F, SER221F, SER222F, SER227F, SER230F, SER234F, SER248A, SER294A, SER296A, SER312F, SER319F, SER321F, SER325F, SER327F, SER329F, SER382F, SER402A, SER413A, SER475F, SER478F, SER511F, SER666A, SER667A, THR193A, THR201A, THR240A, THR293A, THR295A, THR300F, THR354F, THR380F, THR390F, THR393F, THR452F, THR461A, THR461F, THR487F, THR516F, THR517F, THR674A, TRP226F, TRP477F, TYR219A, TYR233F, TYR375A, TYR410A, TYR411A, TYR456F, TYR462A, TYR462F, TYR542A, VAL189F, VAL194A, VAL196A, VAL239A, VAL247A, VAL303F, VAL309F, VAL320F, VAL367A, VAL377F, VAL384F, VAL455F, VAL469A, VAL471A, VAL480F, VAL501A, VAL508F
• B-b: ALA1056b, ALA1089b, ALA341B, ALA347B, ARG1111b, ARG287B, ARG344B, ARG659B, ASN1057b, ASN1058b, ASN657B, ASN682B, ASN691B, ASN719B, ASP1050b, ASP1148b, ASP1152b, ASP648B, ASP658B, ASP661B, ASP683B, ASP715B, GLN1088b, GLU1117b, GLU1122b, GLU1162b, GLU343B, GLU348B, GLU645B, GLU650B, GLU654B, GLY1053b, GLY1116b, GLY1153b, GLY342B, GLY651B, GLY714B, HIS1121b, ILE1060b, ILE289B, ILE646B, ILE656B, ILE689B, LEU1151b, LEU1154b, LEU1179b, LEU338B, LEU340B, LEU652B, LEU685B, LEU687B, LYS1051b, LYS1125b, LYS1150b, LYS1161b, LYS653B, LYS679B, LYS680B, LYS684B, MET350B, MET662B, PHE678B, PRO1114b, PRO1156b, PRO686B, SER1052b, SER1054b, SER1086b, SER1087b, SER1113b, SER1157b, SER339B, SER690B, SER717B, THR1090b, THR1118b, THR286B, THR345B, THR349B, THR649B, THR716B, THR718B, TRP1059b, TRP346B, TYR1119b, TYR1158b, TYR660B, TYR681B, TYR688B, TYR694B, VAL1055b, VAL1112b, VAL1115b, VAL1155b, VAL644B, VAL655B
• B-C: ALA307B, ALA311B, ALA322B, ALA406C, ALA417C, ALA420C, ALA423C, ALA460B, ALA460C, ARG178B, ARG200C, ARG242C, ARG252C, ARG365C, ARG449B, ARG468C, ARG470C, ARG490B, ARG636C, ARG669C, ASN180B, ASN198C, ASN246C, ASN268C, ASN292C, ASN306B, ASN326B, ASN328B, ASN363C, ASN376C, ASN388B, ASN399C, ASN408C, ASN409C, ASN415C, ASN437B, ASN463C, ASN466C, ASN476B, ASN499C, ASN509B, ASP177B, ASP179B, ASP181B, ASP185B, ASP195C, ASP231B, ASP244C, ASP265C, ASP315B, ASP451B, ASP453B, ASP472B, ASP472C, ASP497C, ASP512B, ASP520B, ASP671C, GLN285C, GLN389B, GLN400C, GLN403C, GLN424C, GLN454B, GLN483B, GLN485B, GLN543C, GLN670C, GLU188B, GLU190B, GLU224B, GLU237B, GLU237C, GLU267C, GLU302B, GLU308B, GLU465C, GLU479B, GLU486B, GLU515B, GLY241C, GLY305B, GLY317B, GLY318B, GLY323B, GLY467C, GLY474B, GLY495C, GLY672C, HIS304B, HIS310B, ILE243C, ILE316B, ILE404C, ILE459B, ILE459C, ILE484B, LEU187B, LEU203C, LEU216C, LEU401C, LEU416C, LEU481B, LEU498C, LEU514B, LEU668C, LYS197C, LYS199C, LYS220B, LYS225B, LYS238C, LYS245C, LYS387B, LYS395B, LYS414C, LYS496C, LYS518B, LYS586B, LYS633C, LYS637C, LYS673C, LYS680C, PHE202C, PHE236C, PHE313B, PHE314B, PHE324B, PHE464C, PHE675C, PRO176B, PRO184B, PRO223B, PRO232B, PRO249C, PRO373C, PRO407C, PRO418C, PRO482B, PRO513B, PRO519B, SER186B, SER221B, SER222B, SER227B, SER230B, SER234B, SER248C, SER294C, SER312B, SER319B, SER321B, SER325B, SER327B, SER329B, SER382B, SER402C, SER413C, SER475B, SER478B, SER511B, SER667C, THR201C, THR240C, THR293C, THR295C, THR300B, THR354B, THR380B, THR390B, THR393B, THR452B, THR461B, THR461C, THR473B, THR487B, THR516B, THR517B, THR674C, TRP226B, TRP477B, TYR219C, TYR233B, TYR375C, TYR410C, TYR456B, TYR462B, TYR462C, TYR542C, VAL189B, VAL194C, VAL196C, VAL239C, VAL247C, VAL303B, VAL309B, VAL320B, VAL367C, VAL377B, VAL384B, VAL455B, VAL469C, VAL471C, VAL480B, VAL501C, VAL508B
• C-c: ALA1056c, ALA1089c, ALA341C, ALA347C, ARG1111c, ARG287C, ARG344C, ARG659C, ASN1057c, ASN1058c, ASN657C, ASN682C, ASN691C, ASN719C, ASP1050c, ASP1148c, ASP1152c, ASP648C, ASP658C, ASP661C, ASP683C, ASP715C, GLN1088c, GLU1117c, GLU1122c, GLU1162c, GLU343C, GLU348C, GLU645C, GLU650C, GLU654C, GLY1053c, GLY1116c, GLY1153c, GLY342C, GLY651C, GLY714C, HIS1121c, ILE1060c, ILE289C, ILE646C, ILE656C, ILE689C, LEU1151c, LEU1154c, LEU1179c, LEU338C, LEU340C, LEU652C, LEU685C, LEU687C, LYS1051c, LYS1125c, LYS1150c, LYS1161c, LYS653C, LYS679C, LYS680C, LYS684C, MET350C, MET662C, PHE678C, PRO1114c, PRO1156c, PRO686C, SER1052c, SER1054c, SER1086c, SER1087c, SER1113c, SER1157c, SER339C, SER690C, SER717C, THR1090c, THR1118c, THR286C, THR345C, THR349C, THR649C, THR716C, THR718C, TRP1059c, TRP346C, TYR1119c, TYR1158c, TYR660C, TYR681C, TYR688C, TYR694C, VAL1055c, VAL1112c, VAL1115c, VAL1155c, VAL644C, VAL655C
• C-O: ARG178C, ARG200O, ARG242O, ARG252O, ARG468O, ARG470O, ARG669O, ASP179C, ASP185C, ASP244O, ASP315C, ASP497O, ASP512C, ASP520C, GLU224C, GLU267O, GLU308C, GLU479C, GLU486C, GLU515C, HIS310C, LEU668O, LYS199O, LYS220C, LYS245O, LYS518C, LYS633O, LYS637O, THR201O, THR516C, VAL309C
• D-d: ALA1056d, ALA1089d, ALA341D, ALA347D, ARG1111d, ARG287D, ARG344D, ARG659D, ASN1057d, ASN1058d, ASN657D, ASN682D, ASN691D, ASN719D, ASP1050d, ASP1148d, ASP1152d, ASP648D, ASP658D, ASP661D, ASP683D, ASP715D, GLN1088d, GLU1117d, GLU1122d, GLU1162d, GLU343D, GLU348D, GLU645D, GLU650D, GLU654D, GLY1053d, GLY1116d, GLY1153d, GLY342D, GLY651D, GLY714D, HIS1121d, ILE1060d, ILE289D, ILE646D, ILE656D, ILE689D, LEU1151d, LEU1154d, LEU1179d, LEU338D, LEU340D, LEU652D, LEU685D, LEU687D, LYS1051d, LYS1125d, LYS1150d, LYS1161d, LYS653D, LYS679D, LYS680D, LYS684D, MET350D, MET662D, PHE678D, PRO1114d, PRO1156d, PRO686D, SER1052d, SER1054d, SER1086d, SER1087d, SER1113d, SER1157d, SER339D, SER690D, SER717D, THR1090d, THR1118d, THR286D, THR345D, THR349D, THR649D, THR716D, THR718D, TRP1059d, TRP346D, TYR1119d, TYR1158d, TYR660D, TYR681D, TYR688D, TYR694D, VAL1055d, VAL1112d, VAL1115d, VAL1155d, VAL644D, VAL655D
• D-E: ALA307D, ALA311D, ALA322D, ALA406E, ALA417E, ALA460E, ARG178D, ARG200E, ARG242E, ARG252E, ARG365E, ARG449D, ARG468E, ARG470E, ARG490D, ARG503E, ARG636E, ARG669E, ASN180D, ASN198E, ASN246E, ASN268E, ASN292E, ASN306D, ASN326D, ASN328D, ASN363E, ASN376E, ASN388D, ASN399E, ASN408E, ASN409E, ASN415E, ASN437D, ASN463E, ASN466E, ASN476D, ASN499E, ASN509D, ASP177D, ASP179D, ASP181D, ASP185D, ASP195E, ASP231D, ASP244E, ASP265E, ASP315D, ASP451D, ASP453D, ASP472D, ASP472E, ASP497E, ASP512D, ASP520D, ASP671E, ASP677E, GLN285E, GLN389D, GLN400E, GLN403E, GLN424E, GLN454D, GLN483D, GLN485D, GLN543E, GLN670E, GLU188D, GLU190D, GLU224D, GLU237D, GLU237E, GLU267E, GLU302D, GLU308D, GLU465E, GLU479D, GLU486D, GLU515D, GLY241E, GLY305D, GLY317D, GLY318D, GLY323D, GLY467E, GLY474D, GLY495E, GLY672E, HIS304D, HIS310D, ILE243E, ILE316D, ILE404E, ILE459D, ILE484D, ILE665E, LEU187D, LEU203E, LEU216E, LEU401E, LEU416E, LEU481D, LEU498E, LEU514D, LEU668E, LYS197E, LYS199E, LYS220D, LYS225D, LYS238E, LYS245E, LYS387D, LYS395D, LYS414E, LYS496E, LYS518D, LYS586D, LYS633E, LYS637E, LYS673E, LYS680E, LYS703E, PHE202E, PHE236E, PHE313D, PHE314D, PHE324D, PHE464E, PHE675E, PRO176D, PRO184D, PRO223D, PRO232D, PRO249E, PRO373E, PRO407E, PRO418E, PRO482D, PRO510D, PRO513D, PRO519D, SER186D, SER221D, SER222D, SER227D, SER230D, SER234D, SER248E, SER294E, SER312D, SER319D, SER321D, SER325D, SER327D, SER329D, SER382D, SER402E, SER413E, SER475D, SER478D, SER511D, SER666E, SER667E, THR193E, THR201E, THR240E, THR293E, THR295E, THR300D, THR354D, THR380D, THR390D, THR393D, THR452D, THR461D, THR461E, THR473D, THR487D, THR516D, THR517D, THR674E, TRP226D, TRP477D, TYR219E, TYR233D, TYR375E, TYR410E, TYR411E, TYR456D, TYR462D, TYR462E, TYR542E, VAL189D, VAL194E, VAL196E, VAL239E, VAL247E, VAL303D, VAL309D, VAL320D, VAL367E, VAL377D, VAL384D, VAL455D, VAL469E, VAL471E, VAL480D, VAL501E, VAL508D
• D-O: ARG178O, ARG200D, ARG242D, ARG252D, ARG468D, ARG470D, ARG669D, ASN415D, ASP185O, ASP244D, ASP315O, ASP497D, ASP512O, ASP520O, GLU224O, GLU267D, GLU308O, GLU479O, GLU486O, GLU515O, HIS310O, LEU514O, LYS199D, LYS220O, LYS225O, LYS245D, LYS414D, LYS637D, SER319O, SER325O, SER667D, THR201D, THR240D, THR516O, VAL471D
• E-e: ALA1056e, ALA1089e, ALA341E, ALA347E, ARG1111e, ARG287E, ARG344E, ARG659E, ASN1057e, ASN1058e, ASN657E, ASN682E, ASN691E, ASN719E, ASP1050e, ASP1148e, ASP1152e, ASP648E, ASP658E, ASP661E, ASP683E, ASP715E, GLN1088e, GLU1117e, GLU1122e, GLU1162e, GLU343E, GLU348E, GLU645E, GLU650E, GLU654E, GLY1053e, GLY1116e, GLY1153e, GLY342E, GLY651E, GLY714E, HIS1121e, ILE1060e, ILE289E, ILE646E, ILE656E, ILE689E, LEU1151e, LEU1154e, LEU1179e, LEU338E, LEU340E, LEU652E, LEU685E, LEU687E, LYS1051e, LYS1110e, LYS1125e, LYS1150e, LYS1161e, LYS653E, LYS679E, LYS680E, LYS684E, MET350E, MET662E, PHE678E, PRO1114e, PRO1156e, PRO686E, SER1052e, SER1054e, SER1086e, SER1087e, SER1113e, SER1157e, SER339E, SER690E, SER717E, THR1090e, THR1118e, THR286E, THR345E, THR349E, THR649E, THR716E, THR718E, TRP1059e, TRP346E, TYR1119e, TYR1158e, TYR660E, TYR681E, TYR688E, TYR694E, VAL1055e, VAL1112e, VAL1115e, VAL1155e, VAL644E, VAL655E
• E-F: ALA307E, ALA311E, ALA322E, ALA406F, ALA417F, ALA460F, ARG178E, ARG200F, ARG242F, ARG252F, ARG365F, ARG449E, ARG468F, ARG470F, ARG490E, ARG503F, ARG636F, ARG669F, ASN180E, ASN198F, ASN246F, ASN268F, ASN292F, ASN306E, ASN326E, ASN328E, ASN363F, ASN376F, ASN388E, ASN399F, ASN408F, ASN409F, ASN415F, ASN437E, ASN463F, ASN466F, ASN476E, ASN499F, ASN509E, ASP177E, ASP179E, ASP181E, ASP185E, ASP195F, ASP231E, ASP244F, ASP265F, ASP315E, ASP451E, ASP453E, ASP472E, ASP472F, ASP497F, ASP512E, ASP520E, ASP671F, ASP677F, GLN285F, GLN389E, GLN400F, GLN403F, GLN424F, GLN454E, GLN483E, GLN485E, GLN543F, GLN670F, GLU188E, GLU190E, GLU224E, GLU237E, GLU237F, GLU267F, GLU302E, GLU308E, GLU465F, GLU479E, GLU486E, GLU515E, GLY241F, GLY305E, GLY317E, GLY318E, GLY323E, GLY467F, GLY474E, GLY495F, GLY672F, HIS304E, HIS310E, ILE243F, ILE316E, ILE404F, ILE459E, ILE484E, ILE665F, LEU187E, LEU203F, LEU216F, LEU401F, LEU416F, LEU481E, LEU498F, LEU514E, LEU668F, LYS197F, LYS199F, LYS220E, LYS225E, LYS238F, LYS245F, LYS387E, LYS395E, LYS414F, LYS496F, LYS518E, LYS586E, LYS633F, LYS637F, LYS673F, LYS680F, LYS703F, PHE202F, PHE236F, PHE313E, PHE314E, PHE324E, PHE464F, PHE675F, PRO176E, PRO184E, PRO223E, PRO232E, PRO249F, PRO373F, PRO407F, PRO418F, PRO482E, PRO510E, PRO513E, PRO519E, SER186E, SER221E, SER222E, SER227E, SER230E, SER234E, SER248F, SER294F, SER312E, SER319E, SER321E, SER325E, SER327E, SER329E, SER382E, SER402F, SER413F, SER475E, SER478E, SER511E, SER666F, SER667F, THR193F, THR201F, THR240F, THR293F, THR295F, THR300E, THR354E, THR380E, THR390E, THR393E, THR452E, THR461E, THR461F, THR473E, THR487E, THR516E, THR517E, THR674F, TRP226E, TRP477E, TYR219F, TYR233E, TYR375F, TYR410F, TYR411F, TYR456E, TYR462E, TYR462F, TYR542F, VAL189E, VAL194F, VAL196F, VAL239F, VAL247F, VAL303E, VAL309E, VAL320E, VAL367F, VAL377E, VAL384E, VAL455E, VAL469F, VAL471F, VAL480E, VAL501F, VAL508E
• F-f: ALA1056f, ALA1089f, ALA341F, ALA347F, ARG1111f, ARG287F, ARG344F, ARG659F, ASN1057f, ASN1058f, ASN657F, ASN682F, ASN691F, ASN719F, ASP1050f, ASP1148f, ASP1152f, ASP648F, ASP658F, ASP661F, ASP683F, ASP715F, GLN1088f, GLU1117f, GLU1122f, GLU1162f, GLU343F, GLU348F, GLU645F, GLU650F, GLU654F, GLY1053f, GLY1116f, GLY1153f, GLY342F, GLY651F, GLY714F, HIS1121f, ILE1060f, ILE289F, ILE646F, ILE656F, ILE689F, LEU1151f, LEU1154f, LEU1179f, LEU338F, LEU340F, LEU652F, LEU685F, LEU687F, LYS1051f, LYS1110f, LYS1125f, LYS1150f, LYS1161f, LYS653F, LYS679F, LYS680F, LYS684F, MET350F, MET662F, PHE678F, PRO1114f, PRO1156f, PRO686F, SER1052f, SER1054f, SER1086f, SER1087f, SER1113f, SER1157f, SER339F, SER690F, SER717F, THR1090f, THR1118f, THR286F, THR345F, THR349F, THR649F, THR716F, THR718F, TRP1059f, TRP346F, TYR1119f, TYR1158f, TYR660F, TYR681F, TYR688F, TYR694F, VAL1055f, VAL1112f, VAL1115f, VAL1155f, VAL644F, VAL655F
• G-g: ALA1056g, ALA1089g, ALA341G, ALA347G, ARG1111g, ARG287G, ARG344G, ARG659G, ASN1057g, ASN1058g, ASN657G, ASN682G, ASN691G, ASN719G, ASP1050g, ASP1148g, ASP1152g, ASP648G, ASP658G, ASP661G, ASP683G, ASP715G, GLN1088g, GLU1117g, GLU1122g, GLU1162g, GLU343G, GLU348G, GLU645G, GLU650G, GLU654G, GLY1053g, GLY1116g, GLY1153g, GLY342G, GLY651G, GLY714G, HIS1121g, ILE1060g, ILE289G, ILE646G, ILE656G, ILE689G, LEU1151g, LEU1154g, LEU1179g, LEU338G, LEU340G, LEU652G, LEU685G, LEU687G, LYS1051g, LYS1125g, LYS1150g, LYS1161g, LYS653G, LYS679G, LYS680G, LYS684G, MET350G, MET662G, PHE678G, PRO1114g, PRO1156g, PRO686G, SER1052g, SER1054g, SER1086g, SER1087g, SER1113g, SER1157g, SER339G, SER690G, SER717G, THR1090g, THR1118g, THR286G, THR345G, THR349G, THR649G, THR716G, THR718G, TRP1059g, TRP346G, TYR1119g, TYR1158g, TYR660G, TYR681G, TYR688G, TYR694G, VAL1055g, VAL1112g, VAL1115g, VAL1155g, VAL644G, VAL655G
• G-H: ALA307G, ALA311G, ALA392G, ALA406H, ALA417H, ALA420H, ALA423H, ALA460H, ALA585G, ARG178G, ARG200H, ARG242H, ARG252H, ARG365H, ARG449G, ARG468H, ARG470H, ARG490G, ARG503H, ARG636H, ARG669H, ASN180G, ASN198H, ASN246H, ASN268H, ASN292H, ASN306G, ASN326G, ASN328G, ASN363H, ASN388G, ASN399H, ASN408H, ASN409H, ASN415H, ASN437G, ASN463H, ASN466H, ASN476G, ASN499H, ASN509G, ASP177G, ASP179G, ASP181G, ASP185G, ASP195H, ASP231G, ASP244H, ASP265H, ASP315G, ASP451G, ASP453G, ASP472G, ASP472H, ASP497H, ASP512G, ASP520G, ASP634H, ASP671H, ASP677H, GLN285H, GLN400H, GLN403H, GLN424H, GLN454G, GLN483G, GLN485G, GLN543H, GLN670H, GLU188G, GLU190G, GLU224G, GLU237G, GLU237H, GLU250H, GLU267H, GLU302G, GLU308G, GLU465H, GLU479G, GLU486G, GLU515G, GLY191G, GLY241H, GLY305G, GLY317G, GLY318G, GLY323G, GLY467H, GLY474G, GLY495H, GLY672H, HIS304G, HIS310G, ILE243H, ILE316G, ILE404H, ILE459G, ILE484G, ILE631H, ILE665H, ILE676H, LEU187G, LEU203H, LEU216H, LEU401H, LEU416H, LEU481G, LEU498H, LEU514G, LEU628H, LEU668H, LYS197H, LYS199H, LYS220G, LYS225G, LYS238H, LYS245H, LYS387G, LYS395G, LYS414H, LYS496H, LYS518G, LYS586G, LYS633H, LYS637H, LYS673H, LYS680H, LYS703H, MET521G, PHE202H, PHE236H, PHE313G, PHE314G, PHE324G, PHE464H, PHE675H, PRO176G, PRO184G, PRO223G, PRO232G, PRO249H, PRO373H, PRO407H, PRO418H, PRO482G, PRO510G, PRO513G, PRO519G, SER186G, SER221G, SER222G, SER227G, SER230G, SER234G, SER248H, SER294H, SER296H, SER312G, SER319G, SER321G, SER325G, SER327G, SER329G, SER382G, SER402H, SER413H, SER475G, SER478G, SER511G, SER666H, SER667H, THR193H, THR201H, THR240H, THR293H, THR295H, THR300G, THR354G, THR369H, THR380G, THR390G, THR393G, THR452G, THR461G, THR461H, THR487G, THR516G, THR517G, THR674H, TRP226G, TRP477G, TYR219H, TYR233G, TYR375H, TYR410H, TYR456G, TYR462G, TYR462H, TYR542H, VAL189G, VAL194H, VAL196H, VAL239H, VAL247H, VAL303G, VAL309G, VAL320G, VAL367H, VAL384G, VAL455G, VAL469H, VAL471H, VAL480G, VAL501H, VAL508G
• G-M: ARG178M, ARG200G, ARG242G, ARG252G, ARG468G, ARG470G, ASN415G, ASP185M, ASP231M, ASP244G, ASP315M, ASP472G, ASP497G, ASP512M, ASP520M, GLU224M, GLU267G, GLU479M, GLU486M, GLU515M, HIS310M, LEU514M, LYS199G, LYS220M, LYS225M, LYS245G, LYS414G, SER325M, THR201G, THR240G, VAL471G
• H-h: ALA1056h, ALA1089h, ALA341H, ALA347H, ARG1111h, ARG287H, ARG344H, ARG659H, ASN1057h, ASN1058h, ASN657H, ASN682H, ASN691H, ASN719H, ASP1050h, ASP1148h, ASP1152h, ASP648H, ASP658H, ASP661H, ASP683H, ASP715H, GLN1088h, GLU1117h, GLU1122h, GLU1162h, GLU343H, GLU348H, GLU645H, GLU650H, GLU654H, GLY1053h, GLY1116h, GLY1153h, GLY342H, GLY651H, GLY714H, HIS1121h, ILE1060h, ILE289H, ILE646H, ILE656H, ILE689H, LEU1151h, LEU1154h, LEU1179h, LEU338H, LEU340H, LEU652H, LEU685H, LEU687H, LYS1051h, LYS1125h, LYS1150h, LYS1161h, LYS653H, LYS679H, LYS680H, LYS684H, MET350H, MET662H, PHE678H, PRO1114h, PRO1156h, PRO686H, SER1052h, SER1054h, SER1086h, SER1087h, SER1113h, SER1157h, SER339H, SER690H, SER717H, THR1090h, THR1118h, THR286H, THR345H, THR349H, THR649H, THR716H, THR718H, TRP1059h, TRP346H, TYR1119h, TYR1158h, TYR660H, TYR681H, TYR688H, TYR694H, VAL1055h, VAL1112h, VAL1115h, VAL1155h, VAL644H, VAL655H
• H-I: ALA307H, ALA311H, ALA322H, ALA406I, ALA417I, ALA420I, ALA423I, ALA460I, ALA585H, ARG178H, ARG200I, ARG242I, ARG252I, ARG365I, ARG449H, ARG468I, ARG470I, ARG490H, ARG503I, ARG636I, ARG669I, ASN180H, ASN198I, ASN246I, ASN268I, ASN292I, ASN306H, ASN326H, ASN328H, ASN363I, ASN368I, ASN376I, ASN388H, ASN399I, ASN408I, ASN409I, ASN415I, ASN437H, ASN463I, ASN466I, ASN476H, ASN499I, ASN509H, ASP179H, ASP181H, ASP185H, ASP195I, ASP231H, ASP244I, ASP265I, ASP315H, ASP451H, ASP453H, ASP472H, ASP472I, ASP497I, ASP512H, ASP520H, ASP671I, GLN285I, GLN389H, GLN400I, GLN403I, GLN424I, GLN454H, GLN483H, GLN485H, GLN543I, GLN670I, GLU188H, GLU190H, GLU224H, GLU237H, GLU237I, GLU250I, GLU267I, GLU302H, GLU308H, GLU465I, GLU479H, GLU486H, GLU515H, GLY241I, GLY305H, GLY317H, GLY318H, GLY323H, GLY467I, GLY474H, GLY495I, GLY672I, HIS304H, HIS310H, ILE243I, ILE316H, ILE404I, ILE459H, ILE484H, ILE665I, LEU187H, LEU203I, LEU216I, LEU401I, LEU416I, LEU481H, LEU498I, LEU514H, LEU668I, LYS197I, LYS199I, LYS220H, LYS225H, LYS238I, LYS245I, LYS387H, LYS395H, LYS414I, LYS496I, LYS518H, LYS586H, LYS633I, LYS637I, LYS673I, LYS680I, MET521H, PHE202I, PHE236I, PHE313H, PHE314H, PHE324H, PHE464I, PHE675I, PRO176H, PRO184H, PRO223H, PRO232H, PRO249I, PRO373I, PRO407I, PRO412I, PRO418I, PRO482H, PRO510H, PRO513H, PRO519H, SER186H, SER221H, SER222H, SER227H, SER230H, SER234H, SER248I, SER294I, SER312H, SER319H, SER321H, SER325H, SER327H, SER329H, SER382H, SER402I, SER413I, SER475H, SER478H, SER511H, SER666I, SER667I, THR193I, THR201I, THR240I, THR293I, THR295I, THR300H, THR354H, THR369I, THR380H, THR390H, THR393H, THR452H, THR461H, THR461I, THR473H, THR473I, THR487H, THR488H, THR516H, THR517H, TRP226H, TRP477H, TYR219I, TYR233H, TYR233I, TYR375I, TYR410I, TYR456H, TYR462H, TYR462I, TYR542I, VAL189H, VAL194I, VAL196I, VAL239I, VAL247I, VAL303H, VAL309H, VAL320H, VAL367I, VAL384H, VAL455H, VAL469I, VAL471I, VAL480H, VAL501I, VAL508H
• I-i: ALA341I, ARG1111i, ARG344I, ARG659I, ASN682I, ASP1050i, ASP1148i, ASP1152i, ASP648I, ASP683I, GLU1117i, GLU1122i, GLU650I, GLU654I, GLY1116i, HIS1121i, LYS1051i, LYS1150i, LYS684I, SER1054i, TYR1119i
• I-J: ARG178I, ARG200J, ARG242J, ARG252J, ARG468J, ARG470J, ARG669J, ASP185I, ASP244J, ASP315I, ASP497J, ASP512I, ASP520I, GLN670J, GLU224I, GLU267J, GLU308I, GLU479I, GLU486I, GLU515I, HIS304I, HIS310I, LEU514I, LYS199J, LYS220I, LYS245J, LYS518I, LYS637J, THR201J, THR240J, THR516I
• J-j: ALA341J, ARG1111j, ARG344J, ARG659J, ASN682J, ASP1050j, ASP1148j, ASP1152j, ASP648J, ASP683J, GLU1117j, GLU1122j, GLU650J, GLU654J, GLY1116j, HIS1121j, LYS1051j, LYS1150j, LYS684J, SER1054j, TYR1119j
• J-K: ARG178J, ARG200K, ARG242K, ARG252K, ARG468K, ARG470K, ARG669K, ASP185J, ASP231J, ASP244K, ASP315J, ASP497K, ASP512J, ASP520J, GLU224J, GLU267K, GLU308J, GLU479J, GLU486J, GLU515J, HIS310J, LYS199K, LYS220J, LYS245K, LYS414K, LYS633K, THR201K, THR516J, VAL471K
• K-k: ALA341K, ARG1111k, ARG344K, ARG659K, ASN682K, ASP1050k, ASP1148k, ASP1152k, ASP648K, ASP683K, GLU1117k, GLU1122k, GLU650K, GLU654K, GLY1116k, HIS1121k, LYS1051k, LYS1150k, LYS684K, SER1054k, TYR1119k
• K-L: ARG178K, ARG200L, ARG242L, ARG252L, ARG468L, ARG470L, ARG669L, ASP185K, ASP244L, ASP315K, ASP497L, ASP512K, ASP520K, GLN670L, GLU224K, GLU267L, GLU308K, GLU479K, GLU486K, GLU515K, HIS304K, HIS310K, LEU514K, LEU668L, LYS199L, LYS220K, LYS245L, LYS518K, LYS637L, THR201L, THR240L, THR516K, VAL309K
• L-l: ALA341L, ARG1111l, ARG344L, ARG659L, ASN682L, ASP1050l, ASP1148l, ASP1152l, ASP648L, ASP683L, GLU1117l, GLU1122l, GLU650L, GLU654L, GLY1116l, HIS1121l, LYS1051l, LYS1150l, LYS684L, SER1052l, SER1054l, TYR1119l
• L-M: ARG178L, ARG200M, ARG242M, ARG252M, ARG468M, ARG470M, ARG669M, ASP185L, ASP244M, ASP315L, ASP497M, ASP512L, ASP520L, GLU224L, GLU267M, GLU308L, GLU479L, GLU486L, GLU515L, HIS310L, LEU514L, LYS199M, LYS220L, LYS225L, LYS245M, LYS414M, LYS637M, SER667M, THR201M, THR240M, VAL471M
• M-m: ALA1056m, ARG1111m, ARG344M, ARG659M, ASN682M, ASP1050m, ASP1148m, ASP1152m, ASP648M, ASP683M, GLU1117m, GLU1122m, GLU650M, GLU654M, GLY1116m, HIS1121m, LYS1051m, LYS1150m, LYS684M, SER1054m, TYR688M
• O-o: ARG1111o, ARG344O, ARG659O, ASN682O, ASP1050o, ASP1148o, ASP1152o, ASP648O, ASP683O, GLU1117o, GLU1122o, GLU650O, GLU654O, GLY1116o, HIS1121o, ILE656O, LYS1051o, LYS1150o, LYS684O, SER1054o, SER1087o