1TZH

crystal structure of the fab yads1 complexed with h-vegf

• Total interactions analyzed: 15
• Total true interactions: 11
• Strongest Interaction:
  • Chains: V-H
  • Int. Res.: 42
  • Norm. En. per Res.: -4.2528
• Hub Node: V(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
V-W	-70.3372	-45.7662	-335.511	-451.6144	115	18	9	15336	2	17	15
V-A	-3.8166	0.0	-17.3459	-21.1625	14	1	0	512	0	0	0
V-B	0.0	0.0	-9.698	-9.698	12	0	1	588	0	1	1
V-L	-7.0775	0.0	-65.0007	-72.0782	36	0	2	2862	0	1	0
V-H	-26.7737	-28.5379	-123.304	-178.6157	42	6	3	4906	2	11	3
W-A	-10.9291	0.0	-77.6446	-88.5737	37	1	2	3114	0	1	0
W-B	-17.6717	-24.8764	-136.04	-178.5881	44	5	3	4882	2	11	3
W-L	0.0	0.0	-2.8455	-2.8455	9	0	0	235	0	0	0
W-H	0.0	0.0	-9.6034	-9.6034	14	0	1	548	0	1	1
A-B	-32.6145	-14.7852	-449.975	-497.3747	185	24	13	18050	1	17	16
L-H	-20.4966	-29.4065	-457.823	-507.7261	179	12	12	17973	3	18	15

Interface residues

• V-W: ARG23V, ARG23W, ARG56V, ARG56W, ARG82V, ARG82W, ASN62V, ASN62W, ASP19V, ASP19W, ASP34V, ASP34W, ASP63V, ASP63W, CYS26V, CYS26W, CYS51V, CYS51W, CYS57V, CYS57W, CYS60V, CYS60W, CYS61V, CYS61W, CYS68V, CYS68W, GLN22V, GLN22W, GLN79V, GLN79W, GLN89V, GLN89W, GLN98V, GLN98W, GLU30V, GLU30W, GLU64V, GLU64W, GLU93V, GLU93W, GLY58V, GLY58W, GLY59V, GLY59W, GLY92V, GLY92W, HIS27V, HIS27W, HIS86W, ILE29V, ILE29W, ILE35V, ILE35W, ILE46V, ILE46W, ILE76V, ILE76W, ILE80V, ILE80W, ILE83V, ILE83W, ILE91V, ILE91W, LEU32V, LEU32W, LEU54V, LEU54W, LYS16V, LYS16W, LYS48V, LYS48W, MET18V, MET18W, MET55V, MET55W, MET78V, MET78W, MET81V, MET81W, MET94V, MET94W, PHE17V, PHE17W, PHE47V, PHE47W, PHE96V, PHE96W, PRO28V, PRO28W, PRO49V, PRO49W, PRO53V, PRO53W, SER24V, SER24W, SER50V, SER50W, THR31V, THR31W, THR77V, THR77W, TYR21V, TYR21W, TYR25V, TYR25W, VAL14V, VAL14W, VAL15V, VAL15W, VAL20V, VAL20W, VAL33V, VAL33W, VAL52V, VAL52W
• V-A: ALA28A, ASN62V, ASP63V, GLN27A, GLU64V, GLY65V, GLY68A, LEU66V, PHE17V, SER29A, SER31A, SER94A, THR69A, TYR30A
• V-B: ASP19V, ASP58B, GLY55B, LYS16V, MET18V, PHE17V, THR57B, TYR21V, TYR54B, TYR56B, TYR59B, VAL14V
• V-L: ALA28L, ALA34L, ALA50L, ALA51L, ALA93L, ALA96L, GLN27L, GLN87V, GLN89V, GLY66L, GLY68L, GLY88V, HIS86V, HIS90V, ILE46V, ILE83V, LYS48V, LYS84V, MET81V, PHE47V, PHE71L, PRO85V, PRO95L, SER29L, SER31L, SER32L, SER50V, SER52L, SER67L, SER91L, SER92L, SER94L, TYR30L, TYR49L, TYR53L, VAL33L
• V-H: ALA100H, ALA52H, ARG82V, ASP31H, ASP32H, ASP33H, ASP58H, ASP97H, GLN79V, GLN87V, GLN89V, GLU44V, GLU93V, GLY55H, GLY88V, GLY92V, HIS35H, HIS90V, ILE34H, ILE46V, ILE51H, ILE80V, ILE83V, ILE91V, LYS84V, MET78V, MET81V, MET94V, PRO52H, PRO85V, SER100H, SER53H, SER95H, SER96H, SER99H, THR57H, THR77V, TYR100H, TYR45V, TYR50H, TYR54H, TYR56H
• W-A: ALA28A, ALA34A, ALA50A, ALA51A, ALA93A, ALA96A, GLN27A, GLN87W, GLN89W, GLY66A, GLY68A, GLY88W, HIS86W, HIS90W, ILE2A, ILE46W, ILE83W, LYS48W, LYS84W, MET81W, PHE47W, PHE71A, PRO85W, PRO95A, SER29A, SER31A, SER32A, SER52A, SER67A, SER91A, SER92A, SER94A, THR69A, TYR30A, TYR49A, TYR53A, VAL33A
• W-B: ALA100B, ALA52B, ARG82W, ASP31B, ASP32B, ASP33B, ASP58B, ASP97B, GLN79W, GLN87W, GLN89W, GLU44W, GLU93W, GLY55B, GLY88W, GLY92W, HIS35B, HIS90W, ILE34B, ILE46W, ILE51B, ILE80W, ILE83W, ILE91W, LYS48W, LYS84W, MET78W, MET81W, MET94W, PHE47W, PRO52B, PRO85W, SER100B, SER53B, SER95B, SER96B, SER99B, THR57B, THR77W, TYR100B, TYR45W, TYR50B, TYR54B, TYR56B
• W-L: ALA28L, ASN62W, ASP63W, GLU64W, GLY65W, PHE17W, SER29L, SER94L, TYR30L
• W-H: ALA52H, ASP19W, ASP58H, GLY55H, LYS16W, LYS64H, MET18W, PHE17W, PRO52H, SER53H, THR57H, TYR54H, TYR56H, VAL14W
• A-B: ALA100B, ALA125B, ALA130A, ALA136B, ALA137B, ALA168B, ALA34A, ALA43A, ALA49B, ALA50A, ALA51A, ALA60B, ALA93A, ALA96A, ALA98B, ARG142A, ARG38B, ARG94B, ASN137A, ASN138A, ASP101B, ASP122A, ASP144B, ASP167A, ASP170A, ASP1A, ASP58B, ASP61B, ASP97B, CYS134A, CYS140B, CYS88A, CYS92B, GLN100A, GLN105B, GLN124A, GLN160A, GLN171B, GLN37A, GLN38A, GLN39B, GLN89A, GLU123A, GLU161A, GLU165A, GLU46B, GLU6B, GLY101A, GLY104B, GLY106B, GLY139B, GLY162B, GLY41A, GLY42B, GLY44B, GLY99A, HIS164B, HIS35B, ILE117A, ILE2A, ILE48A, LEU124B, LEU125A, LEU135A, LEU136A, LEU138B, LEU141B, LEU170B, LEU175A, LEU175B, LEU178B, LEU179A, LEU181A, LEU45B, LEU46A, LEU47A, LYS103A, LYS126A, LYS129B, LYS143B, LYS169A, LYS207A, LYS209B, LYS210B, LYS39A, LYS42A, LYS43B, LYS45A, LYS64B, MET100B, PHE116A, PHE118A, PHE122B, PHE139A, PHE166B, PHE209A, PHE98A, PRO119A, PRO120A, PRO123B, PRO126B, PRO167B, PRO40A, PRO44A, PRO95A, SER100B, SER114A, SER120B, SER121A, SER127A, SER127B, SER130B, SER131A, SER159A, SER161B, SER162A, SER168A, SER172B, SER173B, SER174A, SER176A, SER177A, SER177B, SER179B, SER180B, SER186B, SER208A, SER32A, SER56A, SER62B, SER91A, SER92A, SER93B, SER94A, SER95B, SER96B, SER99B, THR129A, THR131B, THR135B, THR160B, THR164A, THR165B, THR172A, THR178A, THR180A, THR183B, THR85A, THR97A, TRP103B, TRP35A, TRP36B, TRP47B, TYR100B, TYR102B, TYR173A, TYR176B, TYR36A, TYR49A, TYR50B, TYR53A, TYR55A, TYR56B, TYR59B, TYR86A, TYR87A, TYR91B, VAL115A, VAL121B, VAL132A, VAL133A, VAL142B, VAL163A, VAL163B, VAL169B, VAL181B, VAL182B, VAL184B, VAL211B, VAL2B, VAL33A, VAL37B, VAL48B, VAL63B, VAL89B
• L-H: ALA100H, ALA125H, ALA130L, ALA136H, ALA137H, ALA168H, ALA34L, ALA43L, ALA49H, ALA50L, ALA51L, ALA60H, ALA93L, ALA96L, ALA98H, ARG142L, ARG38H, ARG94H, ASN137L, ASN138L, ASP101H, ASP122L, ASP144H, ASP167L, ASP170L, ASP1L, ASP58H, ASP61H, CYS134L, CYS140H, CYS88L, CYS92H, GLN100L, GLN105H, GLN124L, GLN160L, GLN171H, GLN37L, GLN38L, GLN39H, GLN89L, GLU123L, GLU161L, GLU165L, GLU46H, GLU6H, GLY101L, GLY104H, GLY106H, GLY128L, GLY139H, GLY162H, GLY41L, GLY42H, GLY44H, GLY99L, HIS164H, HIS35H, ILE117L, ILE2L, ILE48L, LEU124H, LEU125L, LEU135L, LEU136L, LEU138H, LEU141H, LEU170H, LEU175H, LEU175L, LEU178H, LEU179L, LEU181L, LEU45H, LEU46L, LEU47L, LYS103L, LYS117H, LYS126L, LYS143H, LYS169L, LYS209H, LYS39L, LYS42L, LYS43H, LYS45L, LYS64H, MET100H, PHE116L, PHE118L, PHE122H, PHE139L, PHE166H, PHE209L, PHE98L, PRO119L, PRO120L, PRO123H, PRO126H, PRO167H, PRO40L, PRO44L, PRO95L, SER100H, SER114L, SER120H, SER121L, SER127H, SER127L, SER131L, SER159L, SER161H, SER162L, SER168L, SER172H, SER173H, SER174L, SER176L, SER177H, SER177L, SER179H, SER180H, SER186H, SER208L, SER32L, SER56L, SER62H, SER91L, SER92L, SER93H, SER94L, SER95H, SER96H, SER99H, THR129L, THR135H, THR164L, THR165H, THR172L, THR178L, THR180L, THR183H, THR85L, THR97L, TRP103H, TRP35L, TRP36H, TRP47H, TYR100H, TYR102H, TYR173L, TYR176H, TYR36L, TYR49L, TYR50H, TYR53L, TYR55L, TYR56H, TYR59H, TYR86L, TYR87L, TYR91H, VAL115L, VAL121H, VAL132L, VAL133L, VAL142H, VAL163H, VAL163L, VAL169H, VAL181H, VAL182H, VAL184H, VAL211H, VAL33L, VAL37H, VAL48H, VAL63H, VAL89H