1TNO

rat protein geranylgeranyltransferase type-i complexed with a ggpp analog and a kkksktkcvim peptide derived from k- ras4b

• Total interactions analyzed: 153
• Total true interactions: 31
• Strongest Interaction:
  • Chains: K-L
  • Int. Res.: 271
  • Norm. En. per Res.: -4.113
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-114.5737	-100.2183	-820.76	-1035.552	272	29	19	31414	13	89	78
A-G	-12.9861	-26.8238	-64.7524	-104.5623	54	1	0	2755	1	23	11
A-J	0.0	0.0	-0.0322	-0.0322	2	0	0	2	0	3	3
A-K	-6.0806	15.5226	-134.065	-124.623	49	5	1	5858	3	15	18
A-M	-3.631	0.7889	-25.0878	-27.9298	14	0	0	969	0	1	2
B-H	0.0	-22.7962	-7.8012	-30.5974	27	0	0	558	2	17	22
B-I	0.0	0.0	-0.0039	-0.0039	3	0	0	3	0	0	0
B-J	-15.2557	-16.553	-126.22	-158.0287	61	7	0	5201	4	33	26
B-M	0.0	-0.2601	-61.0731	-61.3332	46	1	0	2958	0	4	4
C-D	-120.2294	-96.5059	-830.199	-1046.9343	270	26	19	31649	14	90	78
C-E	-16.5918	-22.1918	-70.7839	-109.5675	60	3	0	2927	2	26	14
C-I	-14.0193	9.1708	-129.596	-134.4446	48	5	1	5815	4	14	18
C-K	0.0	1.3599	-11.0953	-9.7354	15	1	0	560	1	16	12
C-N	-3.4009	0.8047	-24.3882	-26.9844	14	0	0	934	0	1	2
D-F	0.0	0.0	-1.0167	-1.0167	17	0	0	175	0	14	16
D-K	-19.3365	30.842	-65.8593	-54.3537	40	8	0	3111	2	24	22
D-L	0.0	0.0	-1.0125	-1.0125	15	0	0	160	0	7	10
D-N	0.0	-0.2837	-63.2736	-63.5573	46	1	0	3002	0	4	4
E-F	-112.9112	-98.1345	-834.841	-1045.8866	272	25	19	31615	13	91	77
E-I	0.0	3.5986	0.0	3.5986	2	0	0	0	0	10	14
E-O	-3.1872	0.8129	-25.9639	-28.3381	14	0	0	996	0	1	2
F-O	0.0	-0.2533	-61.5477	-61.801	47	3	0	3009	0	4	4
G-H	-127.9211	-99.9484	-829.006	-1056.8756	274	25	19	31508	12	89	78
G-P	-3.0443	0.7808	-24.7412	-27.0047	14	0	0	940	0	1	2
H-P	0.0	-1.0953	-61.6658	-62.7611	46	1	0	2974	0	4	4
I-J	-123.4653	-91.6456	-848.819	-1063.9299	274	23	20	31836	13	90	78
I-Q	-3.0434	0.7564	-24.12	-26.407	14	0	0	914	0	1	2
J-Q	0.0	-1.1117	-61.7906	-62.9023	45	1	0	2954	0	4	4
K-L	-127.4389	-146.0753	-841.108	-1114.6222	271	29	19	31853	12	90	76
K-R	-3.5733	0.7834	-24.0944	-26.8843	14	0	0	925	0	1	2
L-R	0.0	-1.1026	-63.3564	-64.459	46	1	0	2997	0	4	4

Interface residues

• A-B: ALA105A, ALA114B, ALA123B, ALA128A, ALA129A, ALA163B, ALA197A, ALA211B, ALA214B, ALA276A, ALA313A, ALA319B, ALA51B, ALA54B, ARG104A, ARG109A, ARG112A, ARG138A, ARG142A, ARG173A, ARG173B, ARG206A, ARG232A, ARG240A, ARG247B, ARG250B, ARG255B, ARG263B, ARG287A, ARG31B, ARG352A, ARG357A, ARG361A, ARG39B, ARG47B, ARG92B, ARG96B, ARG97A, ASN106B, ASN127A, ASN130A, ASN165A, ASN170B, ASN199A, ASN208B, ASN233A, ASN234A, ASN238A, ASN246A, ASN246B, ASN258B, ASN265B, ASN273A, ASN278A, ASN290B, ASN294B, ASN68B, ASN81A, ASP101A, ASP110A, ASP118B, ASP171B, ASP196A, ASP207B, ASP230A, ASP286A, ASP317A, ASP321A, ASP349A, ASP70B, ASP71B, ASP82A, CYS162B, CYS252B, CYS32B, CYS341A, GLN108A, GLN162A, GLN167A, GLN204A, GLN207A, GLN211A, GLN212B, GLN239A, GLN256B, GLN257B, GLN285A, GLN287B, GLN30B, GLN34B, GLN80A, GLN89A, GLU111A, GLU166B, GLU169B, GLU217B, GLU242B, GLU244B, GLU274A, GLU320A, GLU324A, GLU354A, GLU38B, GLU44B, GLU74B, GLU94A, GLY102B, GLY120B, GLY167B, GLY209B, GLY213B, GLY215B, GLY220B, GLY259B, GLY262B, GLY282A, GLY288A, GLY83A, GLY97B, HIS115B, HIS121B, HIS135A, HIS170A, HIS171A, HIS201A, HIS205A, HIS219B, HIS241A, HIS261B, HIS272A, ILE103B, ILE122B, ILE248B, ILE253B, ILE283A, ILE285B, ILE312A, ILE351A, ILE359A, ILE50B, ILE72B, ILE73B, ILE76B, ILE90A, ILE91A, LEU101B, LEU107A, LEU126A, LEU135B, LEU140A, LEU156B, LEU210B, LEU216B, LEU245B, LEU280A, LEU280B, LEU283B, LEU284A, LEU289A, LEU33B, LEU344A, LEU363A, LEU36B, LEU43B, LEU48B, LEU55B, LEU79B, LYS164A, LYS198A, LYS243B, LYS249B, LYS266B, LYS281A, LYS284B, LYS293B, LYS311B, LYS353A, LYS366A, LYS95A, MET124B, MET172B, MET204B, MET254B, PHE103A, PHE105B, PHE136A, PHE174B, PHE242A, PHE286B, PHE291B, PHE29B, PHE314A, PHE52B, PHE53B, PHE95B, PHE96A, PRO104B, PRO107B, PRO116B, PRO165B, PRO264B, PRO267B, PRO309A, PRO37B, PRO79A, PRO84A, PRO86A, SER119B, SER143A, SER168B, SER203B, SER205B, SER218B, SER222B, SER235A, SER245A, SER275A, SER362A, SER41B, SER42B, SER46B, SER78B, SER85A, SER93A, SER98B, SER99B, THR113B, THR132A, THR289B, THR350A, THR45B, THR49B, TRP169A, TRP203A, TRP208A, TRP216A, TRP237A, TRP251B, TRP277A, TRP356A, TRP75B, TYR100A, TYR100B, TYR117B, TYR131A, TYR166A, TYR199B, TYR200A, TYR206B, TYR250A, TYR260B, TYR279A, TYR288B, TYR310A, TYR355A, TYR358A, TYR40B, TYR92A, VAL106A, VAL133A, VAL139A, VAL164B, VAL174A, VAL231A, VAL236A, VAL270A, VAL316A, VAL35B, VAL67B, VAL78A, VAL87A, VAL88A
• A-G: ARG214A, ARG214G, ASP147A, ASP181A, ASP181G, ASP252A, ASP252G, GLN145A, GLN145G, GLN149A, GLN149G, GLN211A, GLN211G, GLU177A, GLU177G, GLU212A, GLU212G, GLY249A, GLY249G, ILE210A, ILE210G, ILE244A, LEU148A, LEU148G, LEU175G, LEU179A, LEU179G, LEU215A, LEU215G, LYS146A, LYS180A, LYS180G, PHE213A, PHE213G, PRO182A, SER143A, SER143G, SER251A, SER251G, THR247A, THR247G, THR248A, THR248G, TRP178A, TRP178G, TRP216A, TRP216G, TYR250A, TYR250G, VAL176A, VAL176G, VAL209A, VAL209G, VAL255A
• A-J: ASP65J, GLU354A
• A-K: ALA254K, ALA70A, ARG253K, ARG258K, ARG287K, ARG291K, ARG67A, ARG69A, ASN294K, ASN297K, ASP328K, ASP59A, ASP68A, CYS327K, GLN261K, GLN298K, GLU257K, GLU259K, GLU71A, GLU94A, GLY288K, ILE283K, LEU256K, LEU264K, LEU280K, LEU284K, LEU295K, LEU296K, LEU299K, LEU56A, LEU58A, LEU65A, LYS118A, LYS95A, PHE55A, PRO293K, PRO61A, SER290K, SER57A, SER60A, THR62A, TRP72A, TYR262K, TYR292K, TYR63A, TYR66A, VAL255K, VAL260K, VAL64A
• A-M: ALA129A, ASN165A, CYS8M, GLN162A, GLN167A, HIS201A, ILE10M, LYS164A, LYS7M, MET11M, THR6M, TYR131A, TYR166A, VAL9M
• B-H: ALA149H, ALA153B, ALA153H, ARG152B, ARG152H, ARG87H, ASN89B, ASN89H, ASP158B, ASP192B, ASP91B, ASP91H, GLN155B, GLN155H, GLU157B, GLU157H, GLY159B, LEU156B, LEU156H, LEU90B, LEU90H, LYS194B, LYS194H, LYS195B, LYS195H, SER88B, SER88H
• B-I: ARG304B, ASP19B, ILE91I
• B-J: ARG22B, ARG22J, ARG24J, ARG27J, ARG295B, ARG304B, ARG304J, ARG31J, ARG349B, ASN290B, ASN294B, ASN296B, ASP19B, ASP23J, ASP303J, ASP59B, ASP62B, ASP65J, CYS32J, CYS338B, GLN287B, GLN30J, GLN34J, GLU292B, GLU333B, GLU334B, GLY307J, GLY308J, GLY336B, HIS25J, ILE337B, LEU18B, LEU21B, LEU21J, LEU299B, LEU305J, LEU329B, LEU331B, LEU61B, LYS281B, LYS293B, LYS339B, MET332B, MET60B, PHE20B, PHE28J, PHE291B, PHE29J, PRO317J, PRO37J, SER330B, SER335B, SER63B, SER63J, THR348B, VAL26J, VAL306J, VAL340B, VAL35J, VAL66J, VAL67J
• B-M: ALA123B, ALA163B, ALA310B, ARG173B, ARG39B, ASN345B, ASP269B, ASP318B, CYS177B, CYS271B, CYS8M, GLN212B, GLU169B, GLY221B, HIS121B, HIS219B, HIS316B, HIS321B, ILE10M, ILE122B, ILE50B, LEU320B, LEU43B, LEU48B, LYS311B, LYS7M, MET11M, MET124B, PHE174B, PHE324B, PHE52B, PHE53B, PRO317B, SER315B, SER42B, SER46B, THR127B, THR45B, THR49B, THR6M, TRP275B, TRP312B, TYR126B, TYR272B, TYR40B, VAL9M
• C-D: ALA105C, ALA114D, ALA123D, ALA128C, ALA129C, ALA163D, ALA197C, ALA211D, ALA214D, ALA276C, ALA313C, ALA319D, ALA51D, ALA54D, ARG104C, ARG109C, ARG112C, ARG138C, ARG173C, ARG173D, ARG206C, ARG232C, ARG240C, ARG247D, ARG250D, ARG255D, ARG263D, ARG287C, ARG31D, ARG352C, ARG357C, ARG361C, ARG39D, ARG47D, ARG96D, ARG97C, ASN106D, ASN127C, ASN130C, ASN165C, ASN170D, ASN199C, ASN208D, ASN233C, ASN234C, ASN238C, ASN246C, ASN246D, ASN258D, ASN265D, ASN273C, ASN278C, ASN290D, ASN294D, ASN68D, ASN81C, ASP101C, ASP110C, ASP118D, ASP171D, ASP196C, ASP207D, ASP230C, ASP286C, ASP317C, ASP321C, ASP349C, ASP70D, ASP71D, ASP82C, CYS131D, CYS162D, CYS252D, CYS32D, CYS341C, GLN108C, GLN162C, GLN167C, GLN204C, GLN207C, GLN211C, GLN212D, GLN239C, GLN256D, GLN257D, GLN285C, GLN287D, GLN30D, GLN34D, GLN80C, GLN89C, GLU111C, GLU125C, GLU166D, GLU169D, GLU217D, GLU242D, GLU244D, GLU274C, GLU292D, GLU320C, GLU324C, GLU354C, GLU38D, GLU44D, GLU74D, GLU94C, GLY102D, GLY120D, GLY167D, GLY209D, GLY213D, GLY215D, GLY220D, GLY259D, GLY262D, GLY282C, GLY288C, GLY83C, GLY97D, HIS115D, HIS121D, HIS135C, HIS170C, HIS171C, HIS201C, HIS205C, HIS219D, HIS241C, HIS261D, HIS272C, ILE103D, ILE122D, ILE253D, ILE283C, ILE285D, ILE312C, ILE351C, ILE359C, ILE50D, ILE72D, ILE73D, ILE76D, ILE90C, ILE91C, LEU101D, LEU107C, LEU126C, LEU135D, LEU140C, LEU156D, LEU210D, LEU216D, LEU280C, LEU280D, LEU283D, LEU284C, LEU289C, LEU33D, LEU344C, LEU363C, LEU36D, LEU43D, LEU48D, LEU55D, LEU79D, LYS164C, LYS198C, LYS243D, LYS249D, LYS266D, LYS281C, LYS284D, LYS293D, LYS311D, LYS353C, LYS366C, LYS95C, MET124D, MET172D, MET204D, MET254D, PHE103C, PHE105D, PHE136C, PHE174D, PHE242C, PHE286D, PHE291D, PHE29D, PHE314C, PHE52D, PHE53D, PHE95D, PHE96C, PRO104D, PRO107D, PRO116D, PRO165D, PRO264D, PRO267D, PRO309C, PRO37D, PRO79C, PRO84C, PRO86C, SER119D, SER168D, SER203D, SER205D, SER218D, SER222D, SER235C, SER245C, SER275C, SER362C, SER41D, SER42D, SER46D, SER78D, SER85C, SER93C, SER98D, SER99D, THR113D, THR132C, THR289D, THR350C, THR45D, THR49D, TRP169C, TRP203C, TRP208C, TRP216C, TRP237C, TRP251D, TRP277C, TRP356C, TRP75D, TYR100C, TYR100D, TYR117D, TYR131C, TYR166C, TYR199D, TYR200C, TYR206D, TYR250C, TYR260D, TYR279C, TYR288D, TYR310C, TYR355C, TYR358C, TYR40D, TYR92C, VAL106C, VAL133C, VAL139C, VAL164D, VAL174C, VAL231C, VAL236C, VAL270C, VAL316C, VAL35D, VAL67D, VAL78C, VAL87C, VAL88C
• C-E: ARG142E, ARG214C, ARG214E, ASN246C, ASP147E, ASP181C, ASP181E, ASP252C, ASP252E, GLN145C, GLN145E, GLN149C, GLN149E, GLN211C, GLN211E, GLU177C, GLU177E, GLU212C, GLU212E, GLY249C, GLY249E, ILE210C, ILE210E, ILE244C, ILE244E, LEU148C, LEU148E, LEU175C, LEU175E, LEU179C, LEU179E, LEU215C, LEU215E, LYS146E, LYS180C, LYS180E, PHE213C, PHE213E, PRO182C, PRO182E, SER143C, SER143E, SER251C, SER251E, THR247C, THR247E, THR248C, THR248E, TRP178C, TRP178E, TRP216C, TRP216E, TYR250C, TYR250E, VAL176C, VAL176E, VAL209C, VAL209E, VAL255C, VAL255E
• C-I: ALA254C, ALA70I, ARG253C, ARG258C, ARG287C, ARG291C, ARG67I, ARG69I, ASN294C, ASN297C, ASP252C, ASP328C, ASP59I, ASP68I, CYS327C, GLN261C, GLN298C, GLU257C, GLU259C, GLU71I, GLU94I, GLY288C, ILE283C, LEU256C, LEU264C, LEU280C, LEU284C, LEU295C, LEU296C, LEU56I, LEU58I, LEU65I, LYS95I, PHE55I, PRO293C, PRO61I, SER290C, SER57I, SER60I, THR62I, TRP72I, TYR262C, TYR292C, TYR63I, TYR66I, VAL255C, VAL260C, VAL64I
• C-K: ARG357C, ASN335K, ASP332K, GLU339K, GLU342K, GLU347K, GLU354C, ILE343K, LEU338K, LEU340K, LYS336K, LYS346C, LYS346K, LYS353C, THR350C
• C-N: ALA129C, ASN165C, CYS8N, GLN162C, GLN167C, HIS201C, ILE10N, LYS164C, LYS7N, MET11N, THR6N, TYR131C, TYR166C, VAL9N
• D-F: ALA153D, ALA153F, ARG152D, ARG152F, ASP91D, ASP91F, GLN155D, GLN155F, GLU157D, GLU157F, LEU156D, LEU156F, LEU90D, LYS194D, LYS194F, LYS195D, LYS195F
• D-K: ALA345K, ARG295D, ARG357K, ARG361K, ASN290D, ASN294D, ASN296D, ASN335K, ASP19D, CYS341K, GLN287D, GLN364K, GLU292D, GLU333D, GLU334D, GLU339K, GLU342K, GLU347K, GLU354K, GLY336D, GLY360K, ILE337D, LEU18D, LEU299D, LEU329D, LEU338K, LYS293D, LYS346K, LYS353K, MET332D, PHE20D, PHE286D, PHE291D, SER330D, SER335D, THR289D, THR350K, TYR288D, TYR355K, TYR358K
• D-L: ARG22D, ARG295D, ASN290L, ASP19D, ASP23D, GLN287L, GLU333D, GLU333L, GLU334D, GLY336D, PHE20D, PHE291L, SER335D, THR289L, TYR288L
• D-N: ALA123D, ALA163D, ALA310D, ARG173D, ARG39D, ARG47D, ASP269D, ASP318D, CYS177D, CYS271D, CYS8N, GLN212D, GLU169D, GLY221D, HIS121D, HIS219D, HIS316D, HIS321D, ILE10N, ILE122D, ILE50D, LEU320D, LEU43D, LEU48D, LYS311D, LYS7N, MET11N, MET124D, PHE174D, PHE324D, PHE52D, PHE53D, PRO317D, SER315D, SER42D, SER46D, THR127D, THR45D, THR49D, THR6N, TRP275D, TRP312D, TYR126D, TYR272D, TYR40D, VAL9N
• E-F: ALA105E, ALA114F, ALA123F, ALA128E, ALA129E, ALA163F, ALA197E, ALA211F, ALA214F, ALA276E, ALA313E, ALA319F, ALA51F, ALA54F, ARG104E, ARG109E, ARG112E, ARG137E, ARG138E, ARG173E, ARG173F, ARG206E, ARG232E, ARG240E, ARG247F, ARG250F, ARG255F, ARG263F, ARG287E, ARG31F, ARG352E, ARG357E, ARG361E, ARG39F, ARG47F, ARG92F, ARG96F, ARG97E, ASN106F, ASN127E, ASN130E, ASN165E, ASN170F, ASN199E, ASN208F, ASN233E, ASN234E, ASN238E, ASN246E, ASN246F, ASN258F, ASN265F, ASN273E, ASN278E, ASN290F, ASN294F, ASN325E, ASN68F, ASN81E, ASP101E, ASP110E, ASP118F, ASP171F, ASP196E, ASP207F, ASP230E, ASP286E, ASP317E, ASP321E, ASP349E, ASP70F, ASP71F, ASP82E, CYS162F, CYS252F, CYS32F, CYS341E, GLN108E, GLN162E, GLN167E, GLN204E, GLN207E, GLN211E, GLN212F, GLN239E, GLN256F, GLN257F, GLN285E, GLN287F, GLN30F, GLN34F, GLN80E, GLN89E, GLU111E, GLU166F, GLU169F, GLU217F, GLU242F, GLU244F, GLU274E, GLU320E, GLU324E, GLU354E, GLU38F, GLU44F, GLU74F, GLU94E, GLY102F, GLY120F, GLY167F, GLY209F, GLY213F, GLY215F, GLY220F, GLY221F, GLY259F, GLY262F, GLY282E, GLY288E, GLY83E, GLY97F, HIS115F, HIS121F, HIS135E, HIS170E, HIS171E, HIS201E, HIS205E, HIS219F, HIS241E, HIS261F, HIS272E, ILE103F, ILE253F, ILE283E, ILE285F, ILE312E, ILE351E, ILE359E, ILE50F, ILE72F, ILE73F, ILE76F, ILE90E, ILE91E, LEU101F, LEU107E, LEU126E, LEU135F, LEU140E, LEU156F, LEU210F, LEU216F, LEU280E, LEU280F, LEU283F, LEU284E, LEU289E, LEU33F, LEU344E, LEU363E, LEU36F, LEU43F, LEU48F, LEU55F, LEU79F, LYS164E, LYS198E, LYS243F, LYS249F, LYS266F, LYS281E, LYS284F, LYS293F, LYS311F, LYS353E, LYS366E, LYS95E, MET124F, MET172F, MET204F, MET254F, PHE103E, PHE105F, PHE136E, PHE174F, PHE242E, PHE286F, PHE291F, PHE29F, PHE314E, PHE52F, PHE53F, PHE95F, PHE96E, PRO104F, PRO107F, PRO116F, PRO165F, PRO264F, PRO267F, PRO309E, PRO37F, PRO79E, PRO84E, PRO86E, SER119F, SER143E, SER168F, SER203F, SER205F, SER218F, SER222F, SER235E, SER245E, SER275E, SER362E, SER41F, SER42F, SER46F, SER78F, SER85E, SER93E, SER98F, SER99F, THR132E, THR223F, THR289F, THR350E, THR45F, THR49F, TRP134E, TRP169E, TRP203E, TRP208E, TRP216E, TRP237E, TRP251F, TRP277E, TRP356E, TRP75F, TYR100E, TYR100F, TYR117F, TYR131E, TYR166E, TYR199F, TYR200E, TYR206F, TYR250E, TYR260F, TYR279E, TYR288F, TYR310E, TYR355E, TYR358E, TYR40F, TYR92E, VAL106E, VAL133E, VAL139E, VAL164F, VAL174E, VAL231E, VAL236E, VAL270E, VAL316E, VAL35F, VAL67F, VAL78E, VAL87E, VAL88E
• E-I: ASP74E, ASP74I
• E-O: ALA129E, ASN165E, CYS8O, GLN162E, GLN167E, HIS201E, ILE10O, LYS164E, LYS7O, MET11O, THR6O, TYR131E, TYR166E, VAL9O
• F-O: ALA123F, ALA163F, ALA310F, ARG173F, ARG39F, ASN345F, ASP269F, ASP318F, CYS177F, CYS271F, CYS8O, GLN212F, GLU169F, GLY221F, HIS121F, HIS219F, HIS316F, HIS321F, ILE10O, ILE122F, ILE50F, LEU320F, LEU43F, LEU48F, LYS311F, LYS7O, MET11O, MET124F, PHE174F, PHE324F, PHE52F, PHE53F, PRO317F, SER315F, SER42F, SER46F, THR127F, THR270F, THR45F, THR49F, THR6O, TRP275F, TRP312F, TYR126F, TYR272F, TYR40F, VAL9O
• G-H: ALA105G, ALA114H, ALA123H, ALA128G, ALA129G, ALA163H, ALA197G, ALA211H, ALA214H, ALA276G, ALA313G, ALA319H, ALA51H, ALA54H, ARG104G, ARG109G, ARG112G, ARG138G, ARG173G, ARG173H, ARG206G, ARG232G, ARG240G, ARG247H, ARG250H, ARG255H, ARG263H, ARG287G, ARG31H, ARG352G, ARG357G, ARG361G, ARG39H, ARG47H, ARG92H, ARG96H, ARG97G, ASN106H, ASN127G, ASN130G, ASN165G, ASN170H, ASN199G, ASN208H, ASN233G, ASN234G, ASN238G, ASN246G, ASN246H, ASN258H, ASN265H, ASN273G, ASN278G, ASN290H, ASN294H, ASN68H, ASN81G, ASP101G, ASP110G, ASP118H, ASP171H, ASP196G, ASP207H, ASP230G, ASP286G, ASP317G, ASP321G, ASP349G, ASP70H, ASP71H, ASP82G, CYS131H, CYS162H, CYS252H, CYS32H, CYS341G, GLN108G, GLN162G, GLN167G, GLN204G, GLN207G, GLN211G, GLN212H, GLN239G, GLN256H, GLN257H, GLN285G, GLN287H, GLN30H, GLN34H, GLN80G, GLN89G, GLU111G, GLU125G, GLU166H, GLU169H, GLU217H, GLU242H, GLU244H, GLU274G, GLU320G, GLU324G, GLU354G, GLU38H, GLU44H, GLU74H, GLU94G, GLY102H, GLY120H, GLY167H, GLY209H, GLY213H, GLY215H, GLY220H, GLY259H, GLY262H, GLY282G, GLY288G, GLY83G, GLY97H, HIS115H, HIS121H, HIS135G, HIS170G, HIS171G, HIS201G, HIS205G, HIS219H, HIS241G, HIS261H, HIS272G, ILE103H, ILE122H, ILE248H, ILE253H, ILE283G, ILE285H, ILE312G, ILE351G, ILE359G, ILE50H, ILE72H, ILE73H, ILE76H, ILE90G, ILE91G, LEU101H, LEU107G, LEU126G, LEU135H, LEU140G, LEU156H, LEU210H, LEU216H, LEU245H, LEU280G, LEU280H, LEU283H, LEU284G, LEU289G, LEU33H, LEU344G, LEU363G, LEU36H, LEU43H, LEU48H, LEU55H, LEU79H, LYS164G, LYS198G, LYS243H, LYS249H, LYS266H, LYS281G, LYS284H, LYS293H, LYS311H, LYS353G, LYS366G, LYS95G, MET124H, MET172H, MET204H, MET254H, PHE103G, PHE105H, PHE136G, PHE174H, PHE242G, PHE286H, PHE291H, PHE29H, PHE314G, PHE52H, PHE53H, PHE95H, PHE96G, PRO104H, PRO107H, PRO116H, PRO165H, PRO264H, PRO267H, PRO309G, PRO37H, PRO79G, PRO84G, PRO86G, SER119H, SER143G, SER168H, SER203H, SER205H, SER218H, SER222H, SER235G, SER245G, SER275G, SER362G, SER41H, SER42H, SER46H, SER78H, SER85G, SER93G, SER98H, SER99H, THR113H, THR132G, THR289H, THR350G, THR45H, THR49H, TRP134G, TRP169G, TRP203G, TRP208G, TRP216G, TRP237G, TRP251H, TRP277G, TRP356G, TRP75H, TYR100G, TYR100H, TYR117H, TYR131G, TYR166G, TYR199H, TYR200G, TYR206H, TYR250G, TYR260H, TYR279G, TYR288H, TYR310G, TYR355G, TYR358G, TYR40H, TYR92G, VAL106G, VAL133G, VAL139G, VAL164H, VAL174G, VAL231G, VAL236G, VAL270G, VAL316G, VAL35H, VAL67H, VAL78G, VAL87G, VAL88G
• G-P: ALA129G, ASN165G, CYS8P, GLN162G, GLN167G, HIS201G, ILE10P, LYS164G, LYS7P, MET11P, THR6P, TYR131G, TYR166G, VAL9P
• H-P: ALA123H, ALA163H, ALA310H, ARG173H, ARG39H, ASN345H, ASP269H, ASP318H, CYS177H, CYS271H, CYS8P, GLN212H, GLU169H, GLY221H, HIS121H, HIS219H, HIS316H, HIS321H, ILE10P, ILE122H, ILE50H, LEU320H, LEU43H, LEU48H, LYS311H, LYS7P, MET11P, MET124H, PHE174H, PHE324H, PHE52H, PHE53H, PRO317H, SER315H, SER42H, SER46H, THR127H, THR45H, THR49H, THR6P, TRP275H, TRP312H, TYR126H, TYR272H, TYR40H, VAL9P
• I-J: ALA105I, ALA114J, ALA123J, ALA128I, ALA129I, ALA163J, ALA197I, ALA211J, ALA214J, ALA276I, ALA313I, ALA319J, ALA51J, ALA54J, ARG104I, ARG109I, ARG112I, ARG138I, ARG173I, ARG173J, ARG206I, ARG232I, ARG240I, ARG247J, ARG250J, ARG255J, ARG263J, ARG287I, ARG31J, ARG352I, ARG357I, ARG361I, ARG39J, ARG47J, ARG92J, ARG96J, ARG97I, ASN106J, ASN127I, ASN130I, ASN165I, ASN170J, ASN199I, ASN208J, ASN233I, ASN234I, ASN238I, ASN246I, ASN246J, ASN258J, ASN265J, ASN273I, ASN278I, ASN290J, ASN294J, ASN68J, ASN81I, ASP101I, ASP110I, ASP118J, ASP171J, ASP196I, ASP207J, ASP230I, ASP286I, ASP317I, ASP321I, ASP349I, ASP70J, ASP71J, ASP82I, CYS131J, CYS162J, CYS252J, CYS32J, CYS341I, GLN108I, GLN162I, GLN167I, GLN204I, GLN207I, GLN211I, GLN212J, GLN239I, GLN256J, GLN257J, GLN285I, GLN287J, GLN30J, GLN34J, GLN80I, GLN89I, GLU111I, GLU125I, GLU166J, GLU169J, GLU217J, GLU242J, GLU244J, GLU274I, GLU292J, GLU320I, GLU324I, GLU354I, GLU38J, GLU44J, GLU74J, GLU94I, GLY102J, GLY120J, GLY167J, GLY209J, GLY213J, GLY215J, GLY220J, GLY259J, GLY262J, GLY282I, GLY288I, GLY83I, GLY97J, HIS115J, HIS121J, HIS135I, HIS170I, HIS171I, HIS201I, HIS205I, HIS219J, HIS241I, HIS261J, HIS272I, ILE103J, ILE122J, ILE248J, ILE253J, ILE283I, ILE285J, ILE312I, ILE351I, ILE359I, ILE50J, ILE72J, ILE73J, ILE76J, ILE90I, ILE91I, LEU101J, LEU107I, LEU126I, LEU135J, LEU140I, LEU156J, LEU210J, LEU216J, LEU245J, LEU280I, LEU280J, LEU283J, LEU284I, LEU289I, LEU33J, LEU344I, LEU363I, LEU36J, LEU43J, LEU48J, LEU55J, LEU79J, LYS164I, LYS198I, LYS243J, LYS249J, LYS266J, LYS281I, LYS284J, LYS293J, LYS311J, LYS353I, LYS366I, LYS95I, MET124J, MET172J, MET204J, MET254J, PHE103I, PHE105J, PHE136I, PHE174J, PHE242I, PHE286J, PHE291J, PHE29J, PHE314I, PHE52J, PHE53J, PHE95J, PHE96I, PRO104J, PRO107J, PRO116J, PRO165J, PRO264J, PRO267J, PRO309I, PRO37J, PRO79I, PRO84I, PRO86I, SER119J, SER143I, SER168J, SER203J, SER205J, SER218J, SER222J, SER235I, SER245I, SER275I, SER362I, SER41J, SER42J, SER46J, SER78J, SER85I, SER93I, SER98J, SER99J, THR113J, THR132I, THR289J, THR350I, THR45J, THR49J, TRP169I, TRP203I, TRP208I, TRP216I, TRP237I, TRP251J, TRP277I, TRP356I, TRP75J, TYR100I, TYR100J, TYR117J, TYR131I, TYR166I, TYR199J, TYR200I, TYR206J, TYR250I, TYR260J, TYR279I, TYR288J, TYR310I, TYR355I, TYR358I, TYR40J, TYR92I, VAL106I, VAL133I, VAL139I, VAL164J, VAL174I, VAL231I, VAL236I, VAL270I, VAL316I, VAL35J, VAL67J, VAL78I, VAL87I, VAL88I
• I-Q: ALA129I, ASN165I, CYS8Q, GLN162I, GLN167I, HIS201I, ILE10Q, LYS164I, LYS7Q, MET11Q, THR6Q, TYR131I, TYR166I, VAL9Q
• J-Q: ALA123J, ALA163J, ALA310J, ARG173J, ARG39J, ASP269J, ASP318J, CYS177J, CYS271J, CYS8Q, GLN212J, GLU169J, GLY221J, HIS121J, HIS219J, HIS316J, HIS321J, ILE10Q, ILE122J, ILE50J, LEU320J, LEU43J, LEU48J, LYS311J, LYS7Q, MET11Q, MET124J, PHE174J, PHE324J, PHE52J, PHE53J, PRO317J, SER315J, SER42J, SER46J, THR127J, THR45J, THR49J, THR6Q, TRP275J, TRP312J, TYR126J, TYR272J, TYR40J, VAL9Q
• K-L: ALA105K, ALA114L, ALA128K, ALA129K, ALA163L, ALA197K, ALA211L, ALA214L, ALA276K, ALA313K, ALA319L, ALA51L, ALA54L, ARG104K, ARG109K, ARG112K, ARG138K, ARG173K, ARG173L, ARG206K, ARG232K, ARG240K, ARG247L, ARG250L, ARG255L, ARG263L, ARG287K, ARG31L, ARG352K, ARG357K, ARG361K, ARG39L, ARG47L, ARG96L, ARG97K, ASN106L, ASN127K, ASN130K, ASN165K, ASN170L, ASN199K, ASN208L, ASN233K, ASN234K, ASN238K, ASN246K, ASN246L, ASN258L, ASN265L, ASN273K, ASN278K, ASN290L, ASN294L, ASN325K, ASN68L, ASN81K, ASP101K, ASP110K, ASP118L, ASP171L, ASP196K, ASP207L, ASP230K, ASP286K, ASP317K, ASP321K, ASP349K, ASP70L, ASP71L, ASP82K, CYS162L, CYS252L, CYS32L, CYS341K, GLN108K, GLN162K, GLN167K, GLN204K, GLN207K, GLN211K, GLN212L, GLN239K, GLN256L, GLN257L, GLN285K, GLN287L, GLN30L, GLN34L, GLN80K, GLN89K, GLU111K, GLU166L, GLU169L, GLU217L, GLU242L, GLU244L, GLU274K, GLU292L, GLU320K, GLU324K, GLU354K, GLU38L, GLU44L, GLU74L, GLU94K, GLY102L, GLY120L, GLY167L, GLY209L, GLY213L, GLY215L, GLY220L, GLY221L, GLY259L, GLY262L, GLY282K, GLY288K, GLY83K, GLY97L, HIS115L, HIS121L, HIS135K, HIS170K, HIS171K, HIS201K, HIS205K, HIS219L, HIS241K, HIS261L, HIS272K, ILE103L, ILE253L, ILE283K, ILE285L, ILE312K, ILE351K, ILE359K, ILE50L, ILE72L, ILE73L, ILE76L, ILE90K, ILE91K, LEU101L, LEU107K, LEU126K, LEU135L, LEU140K, LEU156L, LEU210L, LEU216L, LEU245L, LEU280K, LEU280L, LEU283L, LEU284K, LEU289K, LEU33L, LEU344K, LEU363K, LEU36L, LEU43L, LEU48L, LEU55L, LEU79L, LYS164K, LYS198K, LYS243L, LYS249L, LYS266L, LYS281K, LYS284L, LYS293L, LYS311L, LYS353K, LYS366K, LYS95K, MET124L, MET172L, MET204L, MET254L, PHE103K, PHE105L, PHE136K, PHE174L, PHE242K, PHE286L, PHE291L, PHE29L, PHE314K, PHE52L, PHE53L, PHE95L, PHE96K, PRO104L, PRO107L, PRO116L, PRO165L, PRO264L, PRO267L, PRO309K, PRO37L, PRO79K, PRO84K, PRO86K, SER119L, SER143K, SER168L, SER203L, SER205L, SER218L, SER222L, SER235K, SER245K, SER275K, SER362K, SER41L, SER42L, SER46L, SER78L, SER85K, SER93K, SER98L, SER99L, THR113L, THR132K, THR223L, THR289L, THR350K, THR45L, THR49L, TRP169K, TRP203K, TRP208K, TRP216K, TRP237K, TRP251L, TRP277K, TRP356K, TRP75L, TYR100K, TYR100L, TYR117L, TYR131K, TYR166K, TYR199L, TYR200K, TYR206L, TYR250K, TYR260L, TYR279K, TYR288L, TYR310K, TYR355K, TYR358K, TYR40L, TYR92K, VAL106K, VAL133K, VAL139K, VAL164L, VAL174K, VAL231K, VAL236K, VAL270K, VAL316K, VAL35L, VAL67L, VAL78K, VAL87K, VAL88K
• K-R: ALA129K, ASN165K, CYS8R, GLN162K, GLN167K, HIS201K, ILE10R, LYS164K, LYS7R, MET11R, THR6R, TYR131K, TYR166K, VAL9R
• L-R: ALA123L, ALA163L, ALA310L, ARG173L, ARG39L, ARG47L, ASN345L, ASP269L, ASP318L, CYS177L, CYS271L, CYS8R, GLU169L, GLY221L, HIS121L, HIS219L, HIS316L, HIS321L, ILE10R, ILE122L, ILE50L, LEU320L, LEU43L, LEU48L, LYS311L, LYS7R, MET11R, MET124L, PHE174L, PHE324L, PHE52L, PHE53L, PRO317L, SER315L, SER42L, SER46L, THR127L, THR45L, THR49L, THR6R, TRP275L, TRP312L, TYR126L, TYR272L, TYR40L, VAL9R