1TN7

protein farnesyltransferase complexed with a tc21 peptide substrate and a fpp analog at 2.3a resolution

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 304
  • Norm. En. per Res.: -4.2117
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-159.6929	-128.9681	-991.696	-1280.357	304	31	17	36595	12	102	108
A-C	-5.1758	0.0	-31.7686	-36.9444	17	0	1	1331	0	1	1
B-C	0.0	0.0	-75.4205	-75.4205	43	2	1	3005	0	6	4

Interface residues

• A-B: ALA128A, ALA129A, ALA197A, ALA202A, ALA276A, ALA313A, ALA345A, ALA592B, ALA598B, ALA623B, ALA651B, ALA747B, ALA822B, ALA834B, ARG104A, ARG137A, ARG138A, ARG173A, ARG206A, ARG232A, ARG240A, ARG352A, ARG357A, ARG361A, ARG527B, ARG532B, ARG534B, ARG584B, ARG587B, ARG600B, ARG702B, ARG731B, ARG780B, ARG783B, ARG791B, ARG97A, ASN127A, ASN130A, ASN165A, ASN199A, ASN233A, ASN234A, ASN238A, ASN246A, ASN273A, ASN278A, ASN734B, ASN769B, ASN793B, ASN81A, ASP110A, ASP196A, ASP230A, ASP286A, ASP317A, ASP321A, ASP349A, ASP537B, ASP538B, ASP591B, ASP597B, ASP625B, ASP700B, ASP820B, ASP82A, CYS595B, CYS604B, CYS627B, CYS633B, CYS732B, CYS792B, GLN108A, GLN162A, GLN167A, GLN195A, GLN204A, GLN207A, GLN211A, GLN239A, GLN285A, GLN364A, GLN536B, GLN548B, GLN588B, GLN628B, GLN646B, GLN733B, GLN775B, GLN781B, GLN789B, GLN80A, GLN818B, GLN832B, GLN833B, GLN89A, GLU229A, GLU274A, GLU320A, GLU324A, GLU347A, GLU354A, GLU529B, GLU533B, GLU541B, GLU547B, GLU594B, GLU698B, GLU736B, GLU746B, GLU785B, GLU94A, GLY282A, GLY360A, GLY585B, GLY641B, GLY642B, GLY643B, GLY645B, GLY696B, GLY697B, GLY737B, GLY740B, GLY741B, GLY744B, GLY749B, GLY750B, GLY786B, GLY787B, GLY790B, GLY83A, HIS135A, HIS170A, HIS171A, HIS201A, HIS205A, HIS241A, HIS272A, HIS306A, HIS530B, HIS649B, HIS694B, HIS748B, HIS812B, HIS827B, HIS831B, ILE267A, ILE283A, ILE351A, ILE359A, ILE546B, ILE607B, ILE621B, ILE663B, ILE739B, ILE90A, ILE91A, LEU107A, LEU126A, LEU193A, LEU227A, LEU269A, LEU280A, LEU284A, LEU289A, LEU344A, LEU363A, LEU535B, LEU582B, LEU586B, LEU589B, LEU596B, LEU603B, LEU608B, LEU630B, LEU632B, LEU650B, LEU692B, LEU770B, LEU773B, LEU774B, LEU795B, LEU808B, LEU811B, LEU815B, LEU823B, LEU835B, LYS164A, LYS198A, LYS228A, LYS268A, LYS281A, LYS346A, LYS348A, LYS353A, LYS366A, LYS771B, LYS794B, LYS856B, LYS95A, MET266A, MET693B, MET745B, MET782B, MET825B, MET829B, PHE103A, PHE136A, PHE242A, PHE314A, PHE629B, PHE640B, PHE784B, PHE788B, PHE830B, PHE860B, PHE96A, PRO271A, PRO309A, PRO601B, PRO644B, PRO648B, PRO652B, PRO743B, PRO79A, PRO821B, PRO84A, PRO86A, SER235A, SER245A, SER275A, SER307A, SER308A, SER362A, SER365A, SER525B, SER539B, SER545B, SER599B, SER772B, SER779B, SER824B, SER826B, SER85A, SER93A, THR132A, THR350A, THR542B, THR544B, THR590B, THR624B, THR653B, THR778B, TRP134A, TRP169A, TRP203A, TRP208A, TRP216A, TRP237A, TRP277A, TRP356A, TRP602B, TRP606B, TRP728B, TRP735B, TRP776B, TRP828B, TYR100A, TYR131A, TYR166A, TYR200A, TYR250A, TYR279A, TYR310A, TYR355A, TYR358A, TYR524B, TYR593B, TYR605B, TYR647B, TYR680B, TYR751B, TYR800B, TYR838B, TYR92A, VAL133A, VAL139A, VAL174A, VAL231A, VAL236A, VAL270A, VAL316A, VAL540B, VAL543B, VAL622B, VAL626B, VAL695B, VAL699B, VAL701B, VAL742B, VAL777B, VAL78A, VAL87A, VAL885B, VAL88A
• A-C: ALA129A, ASN130A, ASN165A, CYS2006C, GLN162A, GLN167A, HIS201A, ILE2008C, LYS164A, LYS2005C, PHE2009C, PRO163A, THR2004C, TYR131A, TYR166A, VAL168A, VAL2007C
• B-C: ALA598B, ALA651B, ALA655B, ARG600B, ARG702B, ARG858B, ASP597B, ASP700B, ASP797B, ASP852B, ASP859B, CYS2006C, CYS595B, CYS706B, CYS799B, GLU698B, GLY750B, GLY855B, HIS649B, HIS748B, HIS862B, ILE2008C, LEU596B, LEU603B, LYS2005C, LYS853B, LYS856B, MET693B, PHE2009C, PRO652B, SER599B, SER857B, THR2004C, TRP602B, TRP606B, TRP803B, TYR605B, TYR654B, TYR751B, TYR800B, TYR861B, TYR865B, VAL2007C