1T6P

crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides

• Total interactions analyzed: 28
• Total true interactions: 15
• Strongest Interaction:
  • Chains: F-H
  • Int. Res.: 334
  • Norm. En. per Res.: -4.2252
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-10.134	-20.9933	-267.648	-298.7752	121	10	13	11713	2	17	29
A-C	-75.0686	-99.5748	-869.9	-1044.5434	280	39	11	35864	10	62	84
A-D	-178.8858	-206.7	-1010.62	-1396.2058	339	37	30	42292	24	103	121
B-C	-188.0557	-208.2194	-994.919	-1391.1941	338	54	30	42167	22	102	118
B-D	-105.2131	-113.365	-876.011	-1094.5891	281	51	11	35618	8	58	77
B-F	0.0	14.6828	-68.9986	-54.3158	53	3	0	2976	0	19	22
C-D	-5.7223	-27.3882	-256.351	-289.4615	123	13	13	11540	3	14	25
C-F	-8.259	-10.3236	-7.7383	-26.3209	36	0	0	720	1	13	14
C-H	0.0	8.6729	-0.0543	8.6186	4	0	0	5	0	2	1
E-F	-5.7447	-13.2545	-266.732	-285.7312	127	8	14	11708	1	14	28
E-G	-161.263	-194.706	-964.547	-1320.516	333	46	30	41241	23	103	121
E-H	-127.7169	-101.3615	-859.848	-1088.9265	283	57	12	36137	8	59	80
F-G	-80.833	-66.8306	-859.11	-1006.7736	287	55	12	36477	6	61	84
F-H	-212.1084	-195.4852	-1003.63	-1411.2236	334	50	28	42745	20	104	121
G-H	-3.9792	-13.8444	-259.864	-277.6876	123	10	13	11366	1	14	24

Interface residues

• A-B: ALA495A, ALA495B, ALA498A, ALA498B, ALA501A, ALA501B, ALA563A, ALA563B, ALA600A, ALA600B, ALA604A, ALA604B, ALA605A, ALA605B, ALA620A, ALA620B, ALA621A, ALA621B, ALA624A, ALA624B, ARG362A, ARG362B, ARG584A, ARG584B, ARG596A, ASN445A, ASN445B, ASN486A, ASN486B, ASN623A, ASN623B, ASP599A, ASP599B, GLN493A, GLN493B, GLN587A, GLN587B, GLU586A, GLU586B, GLU610A, GLU610B, GLY447A, GLY447B, GLY606A, GLY606B, HIS483A, HIS483B, HIS491A, HIS491B, HIS598A, HIS598B, ILE472A, ILE472B, LEU585A, LEU585B, LEU612A, LEU612B, LEU617A, LEU617B, LEU619A, LEU619B, LYS434A, LYS434B, LYS583A, LYS583B, LYS626A, LYS626B, PHE560A, PHE560B, PHE601A, PHE601B, PHE603A, PHE603B, PRO487A, PRO487B, PRO494A, PRO494B, PRO595A, PRO595B, SER602A, SER602B, SER613A, SER613B, SER614A, SER614B, SER616A, SER616B, SER618A, SER618B, THR489A, THR489B, THR490A, THR490B, THR580A, THR580B, THR588A, THR588B, THR607A, THR607B, THR615A, THR615B, TRP625A, TRP625B, TYR363A, TYR363B, TYR591A, TYR591B, VAL488A, VAL488B, VAL492A, VAL492B, VAL608A, VAL608B, VAL609A, VAL609B, VAL611A, VAL611B, VAL622A, VAL622B, VAL627A, VAL627B
• A-C: ALA276A, ALA33C, ALA382A, ALA382C, ALA384A, ALA384C, ALA390A, ALA390C, ALA415A, ALA415C, ALA416A, ALA416C, ALA417A, ALA417C, ALA419A, ALA419C, ALA430A, ALA430C, ALA485A, ALA485C, ALA495A, ALA495C, ALA498A, ALA498C, ALA501A, ALA501C, ARG178A, ARG178C, ARG320A, ARG320C, ARG359C, ARG362A, ARG362C, ARG366A, ARG366C, ARG426A, ARG426C, ASN270A, ASN397A, ASN397C, ASN404A, ASN404C, ASN412A, ASN412C, ASN420A, ASN420C, ASN436A, ASN436C, ASN445A, ASN445C, ASN486A, ASN486C, ASN499A, ASN499C, ASN503A, ASN503C, ASP361A, ASP361C, ASP378A, ASP378C, ASP396A, ASP396C, ASP401A, ASP401C, GLN325A, GLN325C, GLN360A, GLN360C, GLN370A, GLN370C, GLN392A, GLN392C, GLN414A, GLN414C, GLN41C, GLN431A, GLN431C, GLN439A, GLN439C, GLN493A, GLN493C, GLN500A, GLN500C, GLU346A, GLU347A, GLU389A, GLU389C, GLU403A, GLU403C, GLU423A, GLU423C, GLU442A, GLU442C, GLU496A, GLU496C, GLY179A, GLY179C, GLY271C, GLY309A, GLY309C, GLY34C, GLY373A, GLY373C, GLY391A, GLY410A, GLY410C, GLY411A, GLY411C, GLY428A, GLY428C, GLY482A, GLY482C, HIS180A, HIS180C, HIS307A, HIS307C, HIS312A, HIS312C, HIS316A, HIS316C, HIS322A, HIS322C, HIS345C, HIS36A, HIS381A, HIS381C, HIS383C, HIS408A, HIS408C, HIS409A, HIS409C, HIS483A, HIS483C, HIS491A, HIS491C, ILE209A, ILE209C, ILE326A, ILE326C, ILE380A, ILE380C, ILE388A, ILE388C, ILE400A, ILE400C, ILE432A, ILE432C, ILE47C, LEU215A, LEU215C, LEU30A, LEU30C, LEU315A, LEU315C, LEU365A, LEU365C, LEU372A, LEU372C, LEU375A, LEU375C, LEU379A, LEU379C, LEU37A, LEU386A, LEU386C, LEU399A, LEU399C, LEU427A, LEU427C, LEU435A, LEU435C, LEU481A, LEU481C, LEU484A, LEU484C, LEU505A, LEU505C, LYS424A, LYS424C, LYS434A, LYS434C, PHE311A, PHE311C, PHE314A, PHE314C, PHE413A, PHE413C, PHE437A, PHE437C, PRO313A, PRO313C, PRO321A, PRO321C, PRO323A, PRO323C, PRO364A, PRO364C, PRO369A, PRO369C, PRO374A, PRO374C, PRO38A, PRO398A, PRO398C, PRO487A, PRO487C, PRO494A, PRO494C, SER210A, SER210C, SER310A, SER310C, SER35A, SER368A, SER368C, SER377A, SER377C, SER393A, SER393C, SER407A, SER407C, SER479A, SER479C, SER504A, SER504C, THR272A, THR272C, THR319A, THR319C, THR324A, THR324C, THR367A, THR367C, THR387A, THR387C, THR394A, THR394C, THR395A, THR395C, THR39A, THR39C, THR406A, THR406C, THR40A, THR40C, THR421A, THR421C, THR438A, THR438C, THR441A, THR441C, THR478A, THR478C, THR489A, THR489C, THR490A, THR490C, TRP371A, TRP371C, TYR363A, TYR363C, TYR65A, TYR65C, VAL318A, VAL318C, VAL376A, VAL376C, VAL385A, VAL385C, VAL402A, VAL402C, VAL418A, VAL418C, VAL42C, VAL488A, VAL488C, VAL492A, VAL492C, VAL502A, VAL502C
• A-D: ALA127A, ALA127D, ALA133A, ALA133D, ALA223A, ALA223D, ALA430A, ALA430D, ALA457A, ALA473A, ALA473D, ALA474A, ALA474D, ALA475A, ALA475D, ALA476A, ALA476D, ALA485A, ALA485D, ALA495A, ALA495D, ALA498A, ALA498D, ALA525A, ALA525D, ARG151A, ARG151D, ARG154A, ARG154D, ARG206A, ARG206D, ARG247A, ARG247D, ARG426A, ARG426D, ARG511A, ARG511D, ARG512A, ARG512D, ARG678A, ARG678D, ARG679A, ARG679D, ASN158A, ASN158D, ASN445A, ASN445D, ASN486A, ASN486D, ASN499A, ASN499D, ASN503A, ASN503D, ASN694A, ASN694D, ASP126A, ASP126D, ASP148A, ASP148D, ASP214A, ASP214D, ASP230A, ASP230D, ASP471A, ASP471D, ASP518A, ASP518D, ASP681A, ASP681D, CYS140A, CYS140D, CYS455A, CYS455D, CYS467A, CYS467D, GLN131A, GLN131D, GLN138A, GLN138D, GLN493A, GLN493D, GLN500A, GLN500D, GLN687A, GLN687D, GLU125A, GLU125D, GLU136A, GLU136D, GLU157A, GLU157D, GLU163A, GLU163D, GLU241A, GLU241D, GLU423A, GLU423D, GLU442D, GLU480A, GLU480D, GLU496A, GLU496D, GLU515A, GLU515D, GLU688A, GLU688D, GLU700A, GLU700D, GLY141A, GLY141D, GLY153A, GLY153D, GLY155A, GLY155D, GLY207A, GLY207D, GLY227A, GLY227D, GLY433A, GLY469A, GLY469D, GLY482A, GLY482D, GLY680A, GLY680D, GLY685A, GLY685D, GLY692A, GLY692D, HIS137A, HIS137D, HIS228A, HIS228D, HIS234A, HIS234D, HIS466A, HIS466D, HIS483A, HIS483D, HIS491A, HIS491D, ILE128A, ILE128D, ILE202A, ILE202D, ILE209A, ILE209D, ILE243A, ILE243D, ILE472A, ILE472D, ILE508A, ILE508D, ILE691A, ILE691D, ILE698A, ILE698D, LEU130A, LEU130D, LEU134A, LEU134D, LEU135A, LEU135D, LEU139A, LEU139D, LEU143A, LEU143D, LEU152A, LEU152D, LEU156A, LEU156D, LEU160A, LEU160D, LEU162A, LEU162D, LEU205A, LEU205D, LEU215A, LEU215D, LEU244A, LEU260A, LEU260D, LEU266A, LEU444A, LEU444D, LEU463A, LEU463D, LEU470A, LEU470D, LEU481A, LEU481D, LEU484A, LEU484D, LEU505A, LEU505D, LEU507A, LEU507D, LEU520A, LEU520D, LEU522A, LEU522D, LEU523A, LEU523D, LEU684A, LEU684D, LYS132A, LYS132D, LYS232A, LYS232D, LYS240A, LYS240D, LYS242A, LYS242D, LYS434A, LYS434D, LYS468A, LYS468D, LYS686A, LYS686D, LYS697A, LYS697D, LYS703A, LYS703D, PHE147A, PHE147D, PHE150A, PHE150D, PHE437A, PHE437D, PHE683A, PHE683D, PRO144A, PRO144D, PRO161A, PRO161D, PRO204A, PRO204D, PRO217A, PRO217D, PRO229A, PRO229D, PRO461A, PRO461D, PRO487A, PRO487D, PRO494A, PRO494D, SER129A, SER129D, SER145A, SER145D, SER146A, SER146D, SER149A, SER149D, SER159A, SER159D, SER210A, SER210D, SER216A, SER216D, SER226A, SER226D, SER231A, SER231D, SER462A, SER462D, SER464A, SER464D, SER479A, SER479D, SER504A, SER504D, SER509A, SER509D, SER516A, SER516D, SER521A, SER521D, SER693A, SER693D, SER696A, SER696D, THR122D, THR208A, THR208D, THR438A, THR438D, THR441A, THR441D, THR478A, THR478D, THR489A, THR489D, THR490A, THR490D, THR514D, THR526A, THR526D, THR690A, THR690D, TYR220A, TYR220D, TYR245A, TYR245D, TYR465A, TYR465D, TYR477A, TYR477D, TYR529A, TYR529D, TYR699A, TYR699D, VAL142A, VAL142D, VAL164A, VAL164D, VAL165A, VAL165D, VAL203A, VAL203D, VAL233A, VAL233D, VAL235A, VAL235D, VAL236A, VAL236D, VAL488A, VAL488D, VAL492A, VAL492D, VAL519A, VAL519D, VAL682A, VAL682D, VAL689A, VAL689D, VAL695A, VAL695D
• B-C: ALA127B, ALA127C, ALA133B, ALA133C, ALA223B, ALA223C, ALA430B, ALA430C, ALA446B, ALA457B, ALA457C, ALA458B, ALA473B, ALA473C, ALA474B, ALA474C, ALA475B, ALA475C, ALA476B, ALA476C, ALA485B, ALA485C, ALA495B, ALA495C, ALA498B, ALA498C, ALA525B, ALA525C, ALA701B, ARG151B, ARG151C, ARG154B, ARG154C, ARG206B, ARG206C, ARG247B, ARG247C, ARG426B, ARG426C, ARG511B, ARG511C, ARG512B, ARG512C, ARG678B, ARG678C, ARG679B, ARG679C, ASN158B, ASN158C, ASN445B, ASN445C, ASN486B, ASN486C, ASN499B, ASN499C, ASN503B, ASN503C, ASN517B, ASN694B, ASN694C, ASP126B, ASP126C, ASP214B, ASP214C, ASP230B, ASP230C, ASP471B, ASP471C, ASP518B, ASP518C, ASP681B, ASP681C, CYS140B, CYS140C, CYS455B, CYS455C, CYS467B, CYS467C, GLN131B, GLN131C, GLN138B, GLN138C, GLN493B, GLN493C, GLN500B, GLN500C, GLN687B, GLN687C, GLU125B, GLU136B, GLU136C, GLU157B, GLU157C, GLU163B, GLU163C, GLU241B, GLU241C, GLU423B, GLU423C, GLU442B, GLU442C, GLU480B, GLU480C, GLU496B, GLU496C, GLU515B, GLU515C, GLU688B, GLU688C, GLU700B, GLU700C, GLY141B, GLY141C, GLY153B, GLY153C, GLY155B, GLY155C, GLY207B, GLY207C, GLY227B, GLY227C, GLY239B, GLY433B, GLY433C, GLY469B, GLY469C, GLY482B, GLY482C, GLY680B, GLY680C, GLY685B, GLY685C, GLY692B, GLY692C, HIS137B, HIS137C, HIS228B, HIS228C, HIS234B, HIS234C, HIS466B, HIS466C, HIS483B, HIS483C, HIS491B, HIS491C, ILE128B, ILE128C, ILE202B, ILE202C, ILE209B, ILE209C, ILE243B, ILE243C, ILE472B, ILE472C, ILE508B, ILE508C, ILE691B, ILE691C, ILE698B, ILE698C, LEU130B, LEU130C, LEU134B, LEU134C, LEU135B, LEU135C, LEU139B, LEU139C, LEU143B, LEU143C, LEU152B, LEU152C, LEU156B, LEU156C, LEU160B, LEU160C, LEU162B, LEU162C, LEU205B, LEU205C, LEU215B, LEU215C, LEU244B, LEU260B, LEU260C, LEU444B, LEU444C, LEU463B, LEU463C, LEU470B, LEU470C, LEU481B, LEU481C, LEU484B, LEU484C, LEU505B, LEU505C, LEU507B, LEU507C, LEU520B, LEU522B, LEU522C, LEU523B, LEU523C, LEU684B, LEU684C, LYS132B, LYS132C, LYS232C, LYS240B, LYS240C, LYS242B, LYS242C, LYS434B, LYS434C, LYS468B, LYS468C, LYS686B, LYS686C, LYS697B, LYS697C, LYS703B, LYS703C, PHE147B, PHE147C, PHE150B, PHE150C, PHE437B, PHE437C, PHE683B, PHE683C, PRO144B, PRO144C, PRO161B, PRO161C, PRO204B, PRO204C, PRO217B, PRO217C, PRO229B, PRO229C, PRO461B, PRO461C, PRO487B, PRO487C, PRO494B, PRO494C, SER129B, SER129C, SER145B, SER145C, SER146B, SER146C, SER149B, SER149C, SER159B, SER159C, SER210B, SER210C, SER216B, SER216C, SER226B, SER226C, SER231B, SER231C, SER462B, SER462C, SER464B, SER464C, SER479B, SER479C, SER509B, SER509C, SER516B, SER516C, SER521B, SER521C, SER693B, SER693C, SER696B, SER696C, THR208B, THR208C, THR438B, THR438C, THR441B, THR441C, THR478B, THR478C, THR489B, THR489C, THR490B, THR490C, THR514B, THR514C, THR526B, THR526C, THR690B, THR690C, TYR220B, TYR220C, TYR245B, TYR245C, TYR465B, TYR465C, TYR477B, TYR477C, TYR529B, TYR529C, TYR699B, TYR699C, VAL142B, VAL142C, VAL164B, VAL164C, VAL165B, VAL203B, VAL203C, VAL233B, VAL233C, VAL235B, VAL235C, VAL236B, VAL236C, VAL488B, VAL488C, VAL492B, VAL492C, VAL519B, VAL519C, VAL682B, VAL682C, VAL689B, VAL689C, VAL695B, VAL695C
• B-D: ALA276B, ALA276D, ALA308B, ALA329B, ALA33D, ALA382B, ALA382D, ALA384B, ALA384D, ALA390B, ALA390D, ALA415B, ALA415D, ALA416B, ALA416D, ALA417B, ALA417D, ALA419B, ALA419D, ALA430B, ALA430D, ALA485B, ALA485D, ALA495B, ALA495D, ALA498B, ALA498D, ALA501B, ALA501D, ALA506B, ALA506D, ARG178B, ARG178D, ARG320B, ARG320D, ARG362B, ARG362D, ARG366B, ARG366D, ARG426B, ARG426D, ASN270B, ASN270D, ASN397B, ASN397D, ASN404B, ASN404D, ASN412B, ASN412D, ASN420B, ASN420D, ASN436B, ASN436D, ASN445B, ASN445D, ASN486B, ASN486D, ASN499B, ASN499D, ASN503B, ASN503D, ASP317D, ASP361B, ASP361D, ASP378B, ASP378D, ASP396B, ASP396D, ASP401B, ASP401D, GLN325B, GLN325D, GLN360D, GLN370B, GLN370D, GLN392B, GLN392D, GLN414B, GLN414D, GLN41D, GLN431B, GLN431D, GLN439B, GLN439D, GLN493B, GLN493D, GLN500B, GLN500D, GLU346B, GLU389B, GLU389D, GLU403B, GLU403D, GLU423B, GLU423D, GLU442B, GLU442D, GLU496B, GLU496D, GLY179B, GLY179D, GLY309B, GLY309D, GLY373B, GLY373D, GLY410B, GLY410D, GLY411B, GLY411D, GLY428B, GLY428D, GLY482B, GLY482D, HIS180B, HIS180D, HIS307B, HIS307D, HIS312B, HIS312D, HIS316B, HIS316D, HIS322B, HIS322D, HIS345B, HIS36B, HIS381B, HIS381D, HIS383D, HIS408B, HIS408D, HIS409B, HIS409D, HIS483B, HIS483D, HIS491B, HIS491D, ILE209B, ILE209D, ILE326B, ILE326D, ILE380B, ILE380D, ILE388B, ILE388D, ILE400B, ILE400D, ILE432B, ILE47D, LEU215B, LEU215D, LEU30D, LEU315B, LEU315D, LEU365B, LEU365D, LEU372B, LEU372D, LEU375B, LEU375D, LEU379B, LEU379D, LEU37B, LEU386B, LEU386D, LEU399B, LEU399D, LEU427B, LEU427D, LEU429B, LEU435B, LEU435D, LEU481B, LEU481D, LEU484B, LEU484D, LEU505B, LEU505D, LYS424B, LYS424D, LYS434B, LYS434D, PHE311B, PHE311D, PHE314B, PHE314D, PHE413B, PHE413D, PHE437B, PHE437D, PRO313B, PRO313D, PRO321B, PRO321D, PRO323B, PRO323D, PRO364B, PRO364D, PRO369B, PRO369D, PRO374B, PRO374D, PRO38B, PRO398B, PRO398D, PRO487B, PRO487D, PRO494B, PRO494D, SER175B, SER175D, SER210B, SER210D, SER310B, SER310D, SER35B, SER368B, SER368D, SER377B, SER377D, SER393B, SER393D, SER407B, SER407D, SER479B, SER479D, SER504B, SER504D, THR272B, THR272D, THR319B, THR319D, THR324B, THR324D, THR367B, THR367D, THR387B, THR387D, THR394B, THR394D, THR395B, THR395D, THR39B, THR406B, THR406D, THR40B, THR40D, THR421B, THR421D, THR438B, THR438D, THR441B, THR441D, THR478B, THR478D, THR489B, THR489D, THR490B, THR490D, TRP371B, TRP371D, TYR363B, TYR363D, TYR65B, TYR65D, VAL318B, VAL318D, VAL376B, VAL376D, VAL385B, VAL385D, VAL402B, VAL402D, VAL418B, VAL418D, VAL42D, VAL488B, VAL488D, VAL492B, VAL492D, VAL502B, VAL502D
• B-F: ALA249F, ALA251F, ALA647B, ARG638B, ARG641B, ARG679B, ARG80F, ASN193F, ASN196F, ASN254F, ASP460B, ASP57F, ASP592B, GLN639B, GLN687B, GLU238F, GLU248F, GLU459B, GLU642B, GLU688B, GLY239F, GLY685B, GLY79F, HIS197F, HIS237F, ILE634B, LEU244F, LEU252F, LEU255F, LEU463B, LEU593B, LEU636B, LEU684B, LYS240F, LYS242F, LYS686B, LYS78F, PHE253F, PHE644B, PHE683B, PRO81F, SER58F, SER635B, SER646B, THR56F, THR59F, THR637B, THR643B, TRP645B, VAL236F, VAL594B, VAL640B, VAL682B
• C-D: ALA495C, ALA495D, ALA498C, ALA498D, ALA501C, ALA501D, ALA563C, ALA563D, ALA600C, ALA600D, ALA604C, ALA604D, ALA605C, ALA605D, ALA620C, ALA620D, ALA621C, ALA621D, ALA624C, ALA624D, ARG362C, ARG362D, ARG584C, ARG584D, ARG596D, ASN445C, ASN445D, ASN486C, ASN486D, ASN623C, ASN623D, ASP599C, ASP599D, GLN493C, GLN493D, GLN587C, GLN587D, GLU586C, GLU586D, GLU610C, GLU610D, GLY447C, GLY447D, GLY606C, GLY606D, HIS483C, HIS483D, HIS491C, HIS491D, HIS598C, HIS598D, ILE472C, ILE472D, LEU585C, LEU585D, LEU612C, LEU612D, LEU617C, LEU617D, LEU619C, LEU619D, LYS434C, LYS434D, LYS468C, LYS583C, LYS583D, LYS626C, LYS626D, PHE560C, PHE560D, PHE601C, PHE601D, PHE603C, PHE603D, PRO487C, PRO487D, PRO494C, PRO494D, PRO595C, PRO595D, SER590C, SER602C, SER602D, SER613C, SER613D, SER614C, SER614D, SER616C, SER616D, SER618C, SER618D, THR489C, THR489D, THR490C, THR490D, THR580C, THR580D, THR588C, THR588D, THR607C, THR607D, THR615C, THR615D, TRP625C, TRP625D, TYR363C, TYR363D, TYR591C, TYR591D, VAL488C, VAL488D, VAL492C, VAL492D, VAL608C, VAL608D, VAL609C, VAL609D, VAL611C, VAL611D, VAL622C, VAL622D, VAL627C, VAL627D
• C-F: ALA647F, ALA648F, ARG102C, ARG184C, ARG247C, ARG661F, ARG706F, ARG91C, ASN254C, ASN709F, ASP126C, ASP57F, ASP86C, ASP88C, ASP95C, GLU189C, GLU256C, GLU671F, GLU672F, GLY239F, ILE664F, LEU185C, LEU255C, LYS676F, LYS697F, LYS713F, PRO229C, SER646F, SER649F, SER651F, THR56F, THR650F, VAL186C, VAL259C, VAL689F, VAL710F
• C-H: ARG102C, ASP126C, ASP148H, TYR245H
• E-F: ALA495E, ALA495F, ALA498E, ALA498F, ALA501E, ALA501F, ALA563E, ALA563F, ALA600E, ALA600F, ALA604E, ALA604F, ALA605E, ALA605F, ALA620E, ALA620F, ALA621E, ALA621F, ALA624E, ALA624F, ARG362E, ARG362F, ARG584E, ARG584F, ARG596E, ASN445E, ASN445F, ASN486E, ASN486F, ASN589F, ASN623E, ASN623F, ASP599E, ASP599F, GLN493E, GLN493F, GLN587E, GLN587F, GLU586E, GLU586F, GLU610E, GLU610F, GLY447E, GLY447F, GLY606E, GLY606F, HIS483E, HIS483F, HIS491E, HIS491F, HIS598E, HIS598F, ILE472E, ILE472F, LEU585E, LEU585F, LEU612E, LEU612F, LEU617E, LEU617F, LEU619E, LEU619F, LYS434E, LYS434F, LYS468E, LYS468F, LYS579E, LYS579F, LYS583E, LYS583F, LYS626E, LYS626F, PHE560E, PHE560F, PHE601E, PHE601F, PHE603E, PHE603F, PRO487E, PRO487F, PRO494E, PRO494F, PRO595E, PRO595F, SER590F, SER602E, SER602F, SER613E, SER613F, SER614E, SER614F, SER616E, SER616F, SER618E, SER618F, THR489E, THR489F, THR490E, THR490F, THR580E, THR580F, THR588E, THR588F, THR607E, THR607F, THR615E, THR615F, TRP625E, TRP625F, TYR363E, TYR363F, TYR591E, TYR591F, VAL488E, VAL488F, VAL492E, VAL492F, VAL608E, VAL608F, VAL609E, VAL609F, VAL611E, VAL611F, VAL622E, VAL622F, VAL627E, VAL627F
• E-G: ALA127E, ALA127G, ALA133E, ALA133G, ALA223E, ALA223G, ALA430E, ALA430G, ALA446E, ALA457E, ALA457G, ALA458E, ALA473E, ALA473G, ALA474E, ALA474G, ALA475E, ALA475G, ALA476E, ALA476G, ALA485E, ALA485G, ALA495E, ALA495G, ALA498E, ALA498G, ALA525E, ALA525G, ALA701G, ARG151E, ARG151G, ARG154E, ARG154G, ARG206E, ARG206G, ARG247E, ARG426E, ARG426G, ARG511E, ARG511G, ARG512E, ARG512G, ARG678E, ARG678G, ARG679E, ARG679G, ASN158E, ASN158G, ASN445E, ASN445G, ASN486E, ASN486G, ASN499E, ASN499G, ASN503E, ASN503G, ASN694E, ASN694G, ASP126E, ASP126G, ASP148E, ASP214E, ASP214G, ASP230E, ASP230G, ASP471E, ASP471G, ASP518E, ASP518G, ASP681E, ASP681G, CYS140E, CYS140G, CYS455E, CYS455G, CYS467E, CYS467G, GLN131E, GLN131G, GLN138E, GLN138G, GLN493E, GLN493G, GLN500E, GLN500G, GLN687E, GLN687G, GLU125E, GLU125G, GLU136E, GLU136G, GLU157E, GLU157G, GLU163E, GLU163G, GLU241E, GLU241G, GLU423E, GLU423G, GLU442E, GLU480E, GLU480G, GLU496E, GLU496G, GLU515E, GLU515G, GLU688E, GLU688G, GLU700E, GLU700G, GLY141E, GLY141G, GLY153E, GLY153G, GLY155E, GLY155G, GLY207E, GLY207G, GLY227E, GLY227G, GLY469E, GLY469G, GLY482E, GLY482G, GLY680E, GLY680G, GLY685E, GLY685G, GLY692E, GLY692G, HIS137E, HIS137G, HIS228E, HIS228G, HIS234E, HIS234G, HIS466E, HIS466G, HIS483E, HIS483G, HIS491E, HIS491G, ILE128E, ILE128G, ILE202E, ILE202G, ILE209E, ILE209G, ILE243E, ILE243G, ILE472E, ILE472G, ILE508E, ILE508G, ILE691E, ILE691G, ILE698E, ILE698G, LEU130E, LEU130G, LEU134E, LEU134G, LEU135E, LEU135G, LEU139E, LEU139G, LEU143E, LEU143G, LEU152E, LEU152G, LEU156E, LEU156G, LEU160E, LEU160G, LEU162E, LEU162G, LEU205E, LEU205G, LEU215E, LEU215G, LEU244E, LEU244G, LEU260G, LEU444E, LEU444G, LEU463E, LEU463G, LEU470E, LEU470G, LEU481E, LEU481G, LEU484E, LEU484G, LEU505E, LEU505G, LEU507E, LEU507G, LEU520E, LEU520G, LEU522E, LEU522G, LEU523E, LEU523G, LEU684E, LEU684G, LYS132E, LYS132G, LYS232G, LYS240E, LYS240G, LYS242E, LYS242G, LYS434E, LYS434G, LYS468E, LYS468G, LYS686E, LYS686G, LYS697E, LYS697G, LYS703E, LYS703G, PHE147E, PHE147G, PHE150E, PHE150G, PHE437E, PHE437G, PHE683E, PHE683G, PRO144E, PRO144G, PRO161E, PRO161G, PRO204E, PRO204G, PRO217E, PRO217G, PRO229E, PRO229G, PRO461E, PRO461G, PRO487E, PRO487G, PRO494E, PRO494G, SER129E, SER129G, SER145E, SER145G, SER146E, SER146G, SER149E, SER149G, SER159E, SER159G, SER210E, SER210G, SER216E, SER216G, SER226E, SER226G, SER231E, SER231G, SER462E, SER462G, SER464E, SER464G, SER479E, SER479G, SER509E, SER509G, SER516E, SER516G, SER521E, SER521G, SER693E, SER693G, SER696E, SER696G, THR208E, THR208G, THR438E, THR438G, THR441E, THR441G, THR478E, THR478G, THR489E, THR489G, THR490E, THR490G, THR526E, THR526G, THR690E, THR690G, TYR220E, TYR220G, TYR245E, TYR465E, TYR465G, TYR477E, TYR477G, TYR529E, TYR529G, TYR699E, TYR699G, VAL142E, VAL142G, VAL164E, VAL164G, VAL165E, VAL165G, VAL203E, VAL203G, VAL233E, VAL233G, VAL235E, VAL235G, VAL236E, VAL236G, VAL488E, VAL488G, VAL492E, VAL492G, VAL519E, VAL519G, VAL682E, VAL682G, VAL689E, VAL689G, VAL695E, VAL695G
• E-H: ALA276E, ALA276H, ALA382E, ALA382H, ALA384E, ALA384H, ALA390E, ALA390H, ALA415E, ALA415H, ALA416E, ALA416H, ALA417E, ALA417H, ALA419E, ALA419H, ALA430E, ALA430H, ALA485E, ALA485H, ALA495E, ALA495H, ALA498E, ALA498H, ALA501E, ALA501H, ALA506E, ARG178E, ARG178H, ARG320E, ARG320H, ARG362E, ARG362H, ARG366E, ARG366H, ARG426E, ARG426H, ASN270E, ASN270H, ASN397E, ASN397H, ASN404E, ASN404H, ASN412E, ASN412H, ASN420E, ASN420H, ASN436E, ASN436H, ASN445E, ASN445H, ASN486E, ASN486H, ASN499E, ASN499H, ASN503E, ASN503H, ASP317E, ASP317H, ASP361E, ASP361H, ASP378E, ASP378H, ASP396E, ASP396H, ASP401E, ASP401H, GLN325E, GLN325H, GLN360E, GLN360H, GLN370E, GLN370H, GLN392E, GLN392H, GLN414E, GLN414H, GLN41H, GLN431E, GLN431H, GLN439E, GLN439H, GLN493E, GLN493H, GLN500E, GLN500H, GLU346H, GLU389E, GLU389H, GLU403E, GLU403H, GLU423E, GLU423H, GLU442E, GLU442H, GLU496E, GLU496H, GLY179E, GLY179H, GLY271H, GLY309E, GLY309H, GLY373E, GLY373H, GLY410E, GLY410H, GLY411E, GLY411H, GLY428E, GLY428H, GLY482E, GLY482H, HIS180E, HIS180H, HIS307E, HIS307H, HIS312E, HIS312H, HIS316E, HIS316H, HIS322E, HIS322H, HIS345E, HIS345H, HIS36E, HIS381E, HIS381H, HIS383H, HIS408E, HIS408H, HIS409E, HIS409H, HIS483E, HIS483H, HIS491E, HIS491H, ILE209E, ILE209H, ILE326E, ILE326H, ILE380E, ILE380H, ILE388E, ILE388H, ILE400E, ILE400H, ILE432E, ILE432H, ILE47H, LEU215E, LEU215H, LEU30E, LEU315E, LEU315H, LEU365E, LEU365H, LEU372E, LEU372H, LEU375E, LEU375H, LEU379E, LEU379H, LEU37E, LEU386E, LEU386H, LEU399E, LEU399H, LEU427E, LEU427H, LEU435E, LEU435H, LEU481E, LEU481H, LEU484E, LEU484H, LEU505E, LEU505H, LYS424E, LYS424H, LYS434E, LYS434H, PHE311E, PHE311H, PHE314E, PHE314H, PHE413E, PHE413H, PHE437E, PHE437H, PRO313E, PRO313H, PRO321E, PRO321H, PRO323E, PRO323H, PRO364E, PRO364H, PRO369E, PRO369H, PRO374E, PRO374H, PRO38E, PRO398E, PRO398H, PRO487E, PRO487H, PRO494E, PRO494H, SER175E, SER175H, SER210E, SER210H, SER275H, SER310E, SER310H, SER35E, SER368E, SER368H, SER377E, SER377H, SER393E, SER393H, SER407E, SER407H, SER479E, SER479H, SER504E, SER504H, THR272E, THR272H, THR319E, THR319H, THR324E, THR324H, THR367E, THR367H, THR387E, THR387H, THR394E, THR394H, THR395E, THR395H, THR39E, THR39H, THR406E, THR406H, THR40E, THR40H, THR421E, THR421H, THR438E, THR438H, THR441E, THR441H, THR478E, THR478H, THR489E, THR489H, THR490E, THR490H, TRP371E, TRP371H, TYR363E, TYR363H, TYR65E, TYR65H, VAL318E, VAL318H, VAL376E, VAL376H, VAL385E, VAL385H, VAL402E, VAL402H, VAL418E, VAL418H, VAL42H, VAL488E, VAL488H, VAL492E, VAL492H, VAL502E, VAL502H
• F-G: ALA276F, ALA276G, ALA33F, ALA382F, ALA382G, ALA384F, ALA384G, ALA390F, ALA390G, ALA415F, ALA415G, ALA416F, ALA416G, ALA417F, ALA417G, ALA419F, ALA419G, ALA430F, ALA430G, ALA485F, ALA485G, ALA495F, ALA495G, ALA498F, ALA498G, ALA501F, ALA501G, ALA506F, ARG178F, ARG178G, ARG320F, ARG320G, ARG359F, ARG359G, ARG362F, ARG362G, ARG366F, ARG366G, ARG426F, ARG426G, ASN270F, ASN397F, ASN397G, ASN404F, ASN404G, ASN412F, ASN412G, ASN420F, ASN420G, ASN436F, ASN436G, ASN445F, ASN445G, ASN486F, ASN486G, ASN499F, ASN499G, ASN503F, ASN503G, ASP317F, ASP317G, ASP361F, ASP361G, ASP378F, ASP378G, ASP396F, ASP396G, ASP401F, ASP401G, GLN325F, GLN325G, GLN360F, GLN360G, GLN370F, GLN370G, GLN392F, GLN392G, GLN414F, GLN414G, GLN41F, GLN431F, GLN431G, GLN439F, GLN439G, GLN493F, GLN493G, GLN500F, GLN500G, GLU346G, GLU389F, GLU389G, GLU403F, GLU403G, GLU423F, GLU423G, GLU442F, GLU442G, GLU496F, GLU496G, GLY179F, GLY179G, GLY271F, GLY271G, GLY309F, GLY309G, GLY373F, GLY373G, GLY391F, GLY410F, GLY410G, GLY411F, GLY411G, GLY428F, GLY428G, GLY482F, GLY482G, HIS180F, HIS180G, HIS307F, HIS307G, HIS312F, HIS312G, HIS316F, HIS316G, HIS322F, HIS322G, HIS345G, HIS36G, HIS381F, HIS381G, HIS383F, HIS408F, HIS408G, HIS409F, HIS409G, HIS483F, HIS483G, HIS491F, HIS491G, ILE209F, ILE209G, ILE326F, ILE326G, ILE380F, ILE380G, ILE388F, ILE388G, ILE400F, ILE400G, ILE432G, ILE47F, LEU215F, LEU215G, LEU30F, LEU30G, LEU315F, LEU315G, LEU365F, LEU365G, LEU372F, LEU372G, LEU375F, LEU375G, LEU379F, LEU379G, LEU37G, LEU386F, LEU386G, LEU399F, LEU399G, LEU427F, LEU427G, LEU429G, LEU435F, LEU435G, LEU481F, LEU481G, LEU484F, LEU484G, LEU505F, LEU505G, LYS263F, LYS424F, LYS424G, LYS434F, LYS434G, PHE311F, PHE311G, PHE314F, PHE314G, PHE413F, PHE413G, PHE437F, PHE437G, PRO313F, PRO313G, PRO321F, PRO321G, PRO323F, PRO323G, PRO364F, PRO364G, PRO369F, PRO369G, PRO374F, PRO374G, PRO38G, PRO398F, PRO398G, PRO487F, PRO487G, PRO494F, PRO494G, SER175F, SER175G, SER181F, SER210F, SER210G, SER310F, SER310G, SER35G, SER368F, SER368G, SER377F, SER377G, SER393F, SER393G, SER407F, SER407G, SER479F, SER479G, SER504F, SER504G, THR272F, THR272G, THR319F, THR319G, THR324F, THR324G, THR367F, THR367G, THR387F, THR387G, THR394F, THR394G, THR395F, THR395G, THR39F, THR39G, THR406F, THR406G, THR40F, THR421F, THR421G, THR438F, THR438G, THR441F, THR441G, THR478F, THR478G, THR489F, THR489G, THR490F, THR490G, TRP371F, TRP371G, TYR363F, TYR363G, TYR65F, TYR65G, VAL318F, VAL318G, VAL376F, VAL376G, VAL385F, VAL385G, VAL402F, VAL402G, VAL418F, VAL418G, VAL42F, VAL488F, VAL488G, VAL492F, VAL492G, VAL502F, VAL502G
• F-H: ALA127F, ALA127H, ALA133F, ALA133H, ALA223F, ALA223H, ALA430F, ALA430H, ALA457H, ALA473F, ALA473H, ALA474F, ALA474H, ALA475F, ALA475H, ALA476F, ALA476H, ALA485F, ALA485H, ALA495F, ALA495H, ALA498F, ALA498H, ALA525F, ALA525H, ARG151F, ARG151H, ARG154F, ARG154H, ARG206F, ARG206H, ARG247F, ARG247H, ARG426F, ARG426H, ARG511F, ARG511H, ARG512F, ARG512H, ARG678F, ARG678H, ARG679F, ARG679H, ASN158F, ASN158H, ASN445F, ASN445H, ASN486F, ASN486H, ASN499F, ASN499H, ASN503F, ASN503H, ASN694F, ASN694H, ASP126F, ASP126H, ASP148F, ASP148H, ASP214F, ASP214H, ASP230F, ASP230H, ASP471F, ASP471H, ASP518F, ASP518H, ASP681F, ASP681H, CYS140F, CYS140H, CYS455F, CYS455H, CYS467F, CYS467H, GLN131F, GLN131H, GLN138F, GLN138H, GLN493F, GLN493H, GLN500F, GLN500H, GLN687F, GLN687H, GLU125F, GLU125H, GLU136F, GLU136H, GLU157F, GLU157H, GLU163F, GLU163H, GLU241F, GLU241H, GLU423F, GLU423H, GLU442F, GLU480F, GLU480H, GLU496F, GLU496H, GLU515F, GLU515H, GLU688F, GLU688H, GLU700F, GLU700H, GLY141F, GLY141H, GLY153F, GLY153H, GLY155F, GLY155H, GLY207F, GLY207H, GLY227F, GLY227H, GLY433F, GLY433H, GLY469F, GLY469H, GLY482F, GLY482H, GLY680F, GLY680H, GLY685F, GLY685H, GLY692F, GLY692H, HIS137F, HIS137H, HIS228F, HIS228H, HIS234F, HIS234H, HIS466F, HIS466H, HIS483F, HIS483H, HIS491F, HIS491H, ILE128F, ILE128H, ILE202F, ILE202H, ILE209F, ILE209H, ILE243F, ILE243H, ILE472F, ILE472H, ILE508F, ILE508H, ILE691F, ILE691H, ILE698F, ILE698H, LEU130F, LEU130H, LEU134F, LEU134H, LEU135F, LEU135H, LEU139F, LEU139H, LEU143F, LEU143H, LEU152F, LEU152H, LEU156F, LEU156H, LEU160F, LEU160H, LEU162F, LEU162H, LEU205F, LEU205H, LEU215F, LEU215H, LEU260F, LEU260H, LEU444F, LEU444H, LEU463F, LEU463H, LEU470F, LEU470H, LEU481F, LEU481H, LEU484F, LEU484H, LEU505F, LEU505H, LEU507F, LEU507H, LEU520H, LEU522F, LEU522H, LEU523F, LEU523H, LEU684F, LEU684H, LYS132F, LYS132H, LYS232F, LYS232H, LYS240F, LYS240H, LYS242F, LYS242H, LYS434F, LYS434H, LYS468F, LYS468H, LYS686F, LYS686H, LYS697F, LYS697H, LYS703F, LYS703H, PHE147F, PHE147H, PHE150F, PHE150H, PHE437F, PHE437H, PHE683F, PHE683H, PRO144F, PRO144H, PRO161F, PRO161H, PRO204F, PRO204H, PRO217F, PRO217H, PRO229F, PRO229H, PRO461F, PRO461H, PRO487F, PRO487H, PRO494F, PRO494H, SER129F, SER129H, SER145F, SER145H, SER146F, SER146H, SER149F, SER149H, SER159F, SER159H, SER210F, SER210H, SER216F, SER216H, SER226F, SER226H, SER231F, SER231H, SER462F, SER462H, SER464F, SER464H, SER479F, SER479H, SER504H, SER509F, SER509H, SER516F, SER516H, SER521F, SER521H, SER693F, SER693H, SER696F, SER696H, THR208F, THR208H, THR438F, THR438H, THR441F, THR441H, THR478F, THR478H, THR489F, THR489H, THR490F, THR490H, THR513F, THR514H, THR526F, THR526H, THR690F, THR690H, TYR220F, TYR220H, TYR245F, TYR245H, TYR465F, TYR465H, TYR477F, TYR477H, TYR529F, TYR529H, TYR699F, TYR699H, VAL142F, VAL142H, VAL164F, VAL164H, VAL165F, VAL165H, VAL203F, VAL203H, VAL235F, VAL235H, VAL236F, VAL236H, VAL488F, VAL488H, VAL492F, VAL492H, VAL519F, VAL519H, VAL682F, VAL682H, VAL689F, VAL689H, VAL695F, VAL695H
• G-H: ALA495G, ALA495H, ALA498G, ALA498H, ALA501G, ALA501H, ALA563G, ALA563H, ALA600G, ALA600H, ALA604G, ALA604H, ALA605G, ALA605H, ALA620G, ALA620H, ALA621G, ALA621H, ALA624G, ALA624H, ARG362G, ARG362H, ARG584G, ARG584H, ARG596H, ASN445G, ASN445H, ASN486G, ASN486H, ASN589H, ASN623G, ASN623H, ASP599G, ASP599H, GLN493G, GLN493H, GLN587G, GLN587H, GLU586H, GLU610G, GLU610H, GLY447G, GLY447H, GLY606G, GLY606H, HIS483G, HIS483H, HIS491G, HIS491H, HIS598G, HIS598H, ILE472G, ILE472H, LEU585G, LEU585H, LEU612G, LEU612H, LEU617G, LEU617H, LEU619G, LEU619H, LYS434G, LYS434H, LYS468G, LYS583G, LYS583H, LYS626G, LYS626H, PHE560G, PHE560H, PHE601G, PHE601H, PHE603G, PHE603H, PRO487G, PRO487H, PRO494G, PRO494H, PRO595G, PRO595H, SER590H, SER602G, SER602H, SER613G, SER613H, SER614G, SER614H, SER616G, SER616H, SER618G, SER618H, THR489G, THR489H, THR490G, THR490H, THR580G, THR580H, THR588G, THR588H, THR607G, THR607H, THR615G, THR615H, TRP625G, TRP625H, TYR363G, TYR363H, TYR591G, TYR591H, VAL488G, VAL488H, VAL492G, VAL492H, VAL608G, VAL608H, VAL609G, VAL609H, VAL611G, VAL611H, VAL622G, VAL622H, VAL627G, VAL627H