1T5A

human pyruvate kinase m2

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 124
  • Norm. En. per Res.: -4.2344
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-81.4699	-125.8122	-317.787	-525.069	124	27	6	14323	9	41	36
A-C	-132.1446	-160.9373	-726.956	-1020.0379	264	38	19	33002	12	136	105
A-D	0.0	28.6667	-7.7371	20.9296	6	0	0	155	0	2	5
B-C	0.0	26.0352	-6.3968	19.6384	6	0	0	149	0	2	5
B-D	-135.0526	-144.4254	-773.358	-1052.836	267	46	19	33960	14	138	110
C-D	-77.2746	-126.3834	-303.088	-506.7459	125	27	6	13906	10	39	36

Interface residues

• A-B: ALA23A, ALA23B, ALA402A, ALA402B, ALA411A, ALA411B, ALA413A, ALA413B, ALA416A, ALA416B, ALA419A, ALA419B, ARG399A, ARG399B, ARG400A, ARG400B, ARG443A, ARG443B, ARG526A, ARG526B, ASN523A, ASN523B, ASP24A, ASP24B, ASP407A, ASP407B, ASP507A, ASP507B, CYS423A, CYS423B, CYS424A, CYS424B, GLN393A, GLN393B, GLN440A, GLN440B, GLU396A, GLU396B, GLU397A, GLU397B, GLU410A, GLU410B, GLU418A, GLU418B, GLY415A, GLY415B, GLY514A, GLY514B, HIS19A, HIS19B, HIS391A, ILE404A, ILE404B, ILE510A, ILE510B, LEU18A, LEU18B, LEU392A, LEU392B, LEU394A, LEU398A, LEU398B, LEU401A, LEU401B, LEU512A, LEU512B, LYS422A, LYS422B, MET22A, MET22B, MET525A, MET525B, PHE395A, PHE395B, PHE421A, PHE421B, PHE521A, PHE521B, PRO403A, PRO403B, PRO408A, PRO408B, PRO529A, PRO529B, SER406A, SER406B, SER420A, SER420B, SER425A, SER425B, THR25A, THR25B, THR405A, THR405B, THR409A, THR409B, THR412A, THR412B, THR513A, THR513B, THR522A, THR522B, THR524A, THR524B, TRP515A, TRP515B, TYR390A, TYR390B, TYR444A, TYR444B, VAL414A, VAL414B, VAL417A, VAL417B, VAL508A, VAL508B, VAL509A, VAL509B, VAL511A, VAL511B, VAL527A, VAL527B, VAL528A, VAL528B
• A-C: ALA20A, ALA20C, ALA23A, ALA23C, ALA293A, ALA293C, ALA303A, ALA303C, ALA309A, ALA309C, ALA320A, ALA320C, ALA327A, ALA327C, ALA343A, ALA343C, ALA349A, ALA349C, ALA351A, ALA351C, ALA382A, ALA382C, ALA385A, ALA385C, ALA387A, ALA387C, ALA388A, ALA388C, ALA402A, ALA402C, ARG278A, ARG278C, ARG294A, ARG294C, ARG316A, ARG316C, ARG319A, ARG319C, ARG32A, ARG32C, ARG339A, ARG339C, ARG342A, ARG342C, ARG376A, ARG376C, ARG383A, ARG383C, ARG399A, ARG399C, ARG400A, ARG400C, ARG443C, ARG445A, ARG445C, ASN199A, ASN199C, ASN210A, ASN210C, ASN273A, ASN273C, ASN318A, ASN318C, ASN350A, ASN350C, ASN379A, ASN379C, ASP177A, ASP177C, ASP178A, ASP178C, ASP24A, ASP24C, ASP281A, ASP281C, ASP296A, ASP296C, ASP347A, ASP347C, ASP34A, ASP34C, ASP354A, ASP354C, ASP36A, ASP36C, CYS317A, CYS317C, CYS31A, CYS31C, CYS326A, CYS326C, GLN14A, GLN14C, GLN17A, GLN17C, GLN310A, GLN310C, GLN329A, GLN329C, GLN378A, GLN378C, GLN393A, GLN393C, GLU198A, GLU198C, GLU275A, GLU275C, GLU28A, GLU28C, GLU300A, GLU300C, GLU304A, GLU304C, GLU332A, GLU332C, GLU344A, GLU344C, GLU364A, GLU364C, GLU373A, GLU373C, GLU384A, GLU384C, GLU386A, GLU386C, GLU396A, GLU396C, GLU397A, GLU397C, GLY179A, GLY179C, GLY200A, GLY200C, GLY201A, GLY201C, GLY276A, GLY276C, GLY295A, GLY295C, GLY298A, GLY298C, GLY315A, GLY315C, GLY321A, GLY321C, GLY345A, GLY345C, GLY355A, GLY355C, HIS19A, HIS19C, HIS274A, HIS274C, HIS29A, HIS29C, ILE181A, ILE181C, ILE271A, ILE271C, ILE299A, ILE299C, ILE301A, ILE301C, ILE314A, ILE314C, ILE35A, ILE35C, ILE381A, ILE381C, ILE389A, ILE389C, LEU180A, LEU180C, LEU27A, LEU27C, LEU284C, LEU297A, LEU297C, LEU308A, LEU308C, LEU331A, LEU331C, LEU33A, LEU33C, LEU353A, LEU353C, LEU380A, LEU380C, LEU394A, LEU394C, LEU398A, LEU398C, LEU401A, LEU401C, LYS136A, LYS136C, LYS173A, LYS173C, LYS305A, LYS305C, LYS311A, LYS311C, LYS336A, LYS336C, LYS337A, LYS337C, MET30A, MET30C, MET312A, MET312C, MET313A, MET313C, MET330A, MET330C, MET377A, MET377C, PHE26A, PHE26C, PHE280C, PHE307A, PHE307C, PHE395A, PRO212A, PRO212C, PRO302A, PRO302C, PRO338A, PRO338C, PRO340A, PRO340C, PRO38A, PRO38C, PRO39A, PRO39C, SER182A, SER182C, SER333A, SER333C, SER346A, SER346C, SER37A, SER37C, THR25A, THR25C, THR328A, THR328C, THR341A, THR341C, TYR175A, TYR175C, TYR370A, TYR370C, TYR390A, TYR390C, VAL277A, VAL277C, VAL292A, VAL292C, VAL306A, VAL306C, VAL348A, VAL348C, VAL352A, VAL352C
• A-D: ARG400A, ARG400D, ASP24A, ASP24D, THR25A, THR25D
• B-C: ARG400B, ARG400C, ASP24B, ASP24C, THR25B, THR25C
• B-D: ALA20B, ALA20D, ALA23B, ALA23D, ALA293B, ALA293D, ALA303B, ALA303D, ALA309B, ALA309D, ALA320B, ALA320D, ALA327B, ALA327D, ALA343B, ALA343D, ALA349B, ALA349D, ALA351B, ALA351D, ALA382B, ALA382D, ALA385B, ALA385D, ALA387B, ALA387D, ALA388B, ALA388D, ALA402B, ALA402D, ARG278B, ARG278D, ARG294B, ARG294D, ARG316B, ARG316D, ARG319B, ARG319D, ARG32B, ARG32D, ARG339B, ARG339D, ARG342B, ARG342D, ARG376B, ARG376D, ARG383B, ARG383D, ARG399B, ARG399D, ARG400B, ARG400D, ARG443D, ARG445B, ARG445D, ASN199B, ASN199D, ASN210B, ASN210D, ASN273B, ASN273D, ASN318B, ASN318D, ASN350B, ASN350D, ASN379B, ASN379D, ASP177B, ASP177D, ASP178B, ASP178D, ASP24B, ASP24D, ASP281B, ASP281D, ASP296B, ASP296D, ASP347B, ASP347D, ASP34B, ASP34D, ASP354B, ASP354D, ASP36B, ASP36D, CYS317B, CYS317D, CYS31B, CYS31D, CYS326B, CYS326D, GLN14B, GLN14D, GLN16B, GLN17B, GLN17D, GLN310B, GLN310D, GLN329B, GLN329D, GLN378B, GLN378D, GLN393B, GLN393D, GLU198B, GLU198D, GLU275B, GLU275D, GLU28B, GLU28D, GLU300B, GLU300D, GLU304B, GLU304D, GLU332B, GLU332D, GLU344B, GLU344D, GLU364B, GLU364D, GLU373B, GLU373D, GLU384B, GLU384D, GLU386B, GLU386D, GLU396B, GLU396D, GLU397B, GLU397D, GLY179B, GLY179D, GLY200B, GLY200D, GLY201B, GLY201D, GLY276B, GLY276D, GLY295B, GLY295D, GLY298B, GLY298D, GLY315B, GLY315D, GLY321B, GLY321D, GLY345B, GLY345D, GLY355B, GLY355D, HIS19B, HIS19D, HIS274B, HIS274D, HIS29B, HIS29D, ILE181B, ILE181D, ILE271B, ILE271D, ILE299B, ILE299D, ILE301B, ILE301D, ILE314B, ILE314D, ILE335D, ILE35B, ILE35D, ILE381B, ILE381D, ILE389B, ILE389D, LEU180B, LEU180D, LEU27B, LEU27D, LEU297B, LEU297D, LEU308B, LEU308D, LEU331B, LEU331D, LEU33B, LEU33D, LEU353B, LEU353D, LEU380B, LEU380D, LEU394B, LEU394D, LEU398B, LEU398D, LEU401B, LEU401D, LYS136B, LYS136D, LYS173B, LYS173D, LYS305B, LYS305D, LYS311B, LYS311D, LYS336B, LYS336D, LYS337B, LYS337D, MET30B, MET30D, MET312B, MET312D, MET313B, MET313D, MET330B, MET330D, MET377B, MET377D, PHE26B, PHE26D, PHE280B, PHE280D, PHE307B, PHE307D, PHE395B, PHE395D, PRO212B, PRO212D, PRO302B, PRO302D, PRO338B, PRO338D, PRO340B, PRO340D, PRO38B, PRO38D, PRO39B, PRO39D, SER182B, SER182D, SER333B, SER333D, SER346B, SER346D, SER37B, SER37D, THR25B, THR25D, THR328B, THR328D, THR341B, THR341D, TYR175B, TYR175D, TYR370B, TYR370D, TYR390B, TYR390D, VAL277B, VAL277D, VAL292B, VAL292D, VAL306B, VAL306D, VAL348B, VAL348D, VAL352B, VAL352D
• C-D: ALA23C, ALA23D, ALA402C, ALA402D, ALA411C, ALA411D, ALA413C, ALA413D, ALA416C, ALA416D, ALA419C, ALA419D, ARG399C, ARG399D, ARG400C, ARG400D, ARG443C, ARG443D, ARG526C, ARG526D, ASN523C, ASN523D, ASP24C, ASP24D, ASP407C, ASP407D, ASP507C, ASP507D, CYS423C, CYS423D, CYS424C, CYS424D, GLN393C, GLN393D, GLN440C, GLN440D, GLU396C, GLU396D, GLU397C, GLU397D, GLU410C, GLU410D, GLU418C, GLU418D, GLY415C, GLY415D, GLY514C, GLY514D, HIS19C, HIS19D, HIS391C, HIS391D, ILE404C, ILE404D, ILE510C, ILE510D, LEU18C, LEU18D, LEU392C, LEU392D, LEU394C, LEU394D, LEU398C, LEU398D, LEU401C, LEU401D, LEU512C, LEU512D, LYS422C, LYS422D, MET22C, MET22D, MET525C, MET525D, PHE395C, PHE395D, PHE421C, PHE421D, PHE521C, PRO403C, PRO403D, PRO408C, PRO408D, PRO529C, PRO529D, SER406C, SER406D, SER420C, SER420D, SER425C, SER425D, THR25C, THR25D, THR405C, THR405D, THR409C, THR409D, THR412C, THR412D, THR513C, THR513D, THR522C, THR522D, THR524C, THR524D, TRP515C, TRP515D, TYR390C, TYR390D, TYR444C, TYR444D, VAL414C, VAL414D, VAL417C, VAL417D, VAL508C, VAL508D, VAL509C, VAL509D, VAL511C, VAL511D, VAL527C, VAL527D, VAL528C, VAL528D