1SVM

co-crystal structure of sv40 large t antigen helicase domain and atp

• Total interactions analyzed: 15
• Total true interactions: 14
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 207
  • Norm. En. per Res.: -3.0001
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-76.1438	-69.6701	-475.206	-621.0199	207	43	15	22635	11	83	80
A-C	0.0	6.8912	-1.2696	5.6216	5	0	0	74	0	2	3
A-D	0.0	0.0	-0.0328	-0.0328	2	0	0	11	0	1	2
A-E	0.0	0.0	-0.0067	-0.0067	6	0	0	9	0	2	4
A-F	-72.4706	-59.9858	-467.895	-600.3514	208	34	15	21747	11	82	85
B-C	-79.6412	-59.1299	-453.147	-591.9182	203	23	15	21110	8	82	85
B-D	0.0	6.3732	-0.001	6.3722	6	0	0	2	0	2	4
B-F	0.0	0.0	-0.0922	-0.0922	4	0	0	18	0	2	4
C-D	-77.6733	-48.5091	-481.586	-607.7684	208	40	15	22027	11	82	86
C-E	0.0	6.7747	-0.0111	6.7636	5	0	0	4	0	2	4
C-F	0.0	0.0	-0.0121	-0.0121	2	0	0	7	0	0	2
D-E	-87.7605	-54.062	-470.65	-612.4725	208	27	16	21883	8	82	83
D-F	0.0	6.7691	-0.5025	6.2666	5	0	0	41	0	2	3
E-F	-88.9875	-41.1887	-455.507	-585.6832	207	22	15	21273	8	85	88

Interface residues

• A-B: ALA324B, ALA325B, ALA328B, ALA340A, ALA346A, ALA436B, ALA437B, ALA438B, ALA447B, ALA464B, ALA539A, ARG349A, ARG357A, ARG364B, ARG371B, ARG420A, ARG456A, ARG456B, ARG483B, ARG498A, ARG517A, ARG540A, ARG567B, ASN332A, ASN332B, ASN415A, ASN449B, ASN451B, ASN458A, ASN492A, ASN493A, ASN496A, ASN508A, ASN515A, ASN515B, ASN529B, ASP283B, ASP284B, ASP329B, ASP342A, ASP351A, ASP429B, ASP455A, ASP455B, ASP466A, ASP474B, ASP484B, ASP495A, ASP499A, ASP502A, CYS337B, CYS411A, GLN267A, GLN296B, GLN310B, GLN333B, GLN338A, GLN338B, GLN339A, GLN354A, GLN359A, GLN467B, GLN489B, GLN519A, GLN538A, GLN570B, GLU275A, GLU294B, GLU309B, GLU441B, GLU460A, GLU460B, GLU473B, GLU481B, GLU510A, GLU530B, GLU558B, GLU561B, GLU565B, GLY290B, GLY431B, GLY445B, GLY462B, GLY477B, GLY480B, GLY488B, GLY490B, GLY503A, HIS313B, HIS513A, HIS513B, ILE326B, ILE336A, ILE336B, ILE416A, ILE428B, ILE465A, ILE491A, ILE520A, ILE568B, ILE569B, LEU272A, LEU286B, LEU287B, LEU288B, LEU289B, LEU293B, LEU345A, LEU353A, LEU355A, LEU439B, LEU440B, LEU448B, LEU452B, LEU454A, LEU454B, LEU457A, LEU457B, LEU461A, LEU461B, LEU485B, LEU494A, LEU497A, LEU509A, LEU514A, LEU514B, LEU537A, LEU557B, LEU563B, LEU564B, LYS271A, LYS304B, LYS331B, LYS334B, LYS347A, LYS348A, LYS418A, LYS419A, LYS432B, LYS446B, LYS476B, LYS506A, LYS511A, LYS511B, LYS512A, LYS512B, LYS516A, LYS535A, LYS554B, LYS566B, MET278A, MET291B, MET412A, MET528B, PHE327B, PHE459A, PHE459B, PHE472B, PHE562B, PRO311B, PRO417A, PRO427B, PRO453A, PRO453B, PRO486B, PRO523A, PRO534A, SER269A, SER312B, SER330B, SER352A, SER430B, SER482B, SER487B, SER504A, THR274A, THR280B, THR335A, THR335B, THR343A, THR356A, THR433B, THR434B, THR518A, THR527B, THR536A, TRP270A, TYR276B, TYR292B, TYR297B, TYR414A, TYR500A, TYR531B, VAL268A, VAL285B, VAL341A, VAL341B, VAL344A, VAL350A, VAL413A, VAL450B, VAL463B, VAL471B, VAL475B, VAL505A, VAL507A, VAL533A
• A-C: ARG456C, ASP455A, ASP455C, HIS513A, HIS513C
• A-D: HIS513A, HIS513D
• A-E: ARG456A, ARG456E, ASP455E, HIS513A, LYS512E, PHE459E
• A-F: ALA324A, ALA325A, ALA328A, ALA340F, ALA346F, ALA436A, ALA437A, ALA438A, ALA447A, ALA464A, ALA539F, ARG349F, ARG357F, ARG364A, ARG371A, ARG420F, ARG456A, ARG456F, ARG483A, ARG498F, ARG517F, ARG540F, ARG567A, ASN332A, ASN332F, ASN415F, ASN449A, ASN451A, ASN458A, ASN458F, ASN492F, ASN493F, ASN496F, ASN508F, ASN515F, ASN529A, ASP283A, ASP284A, ASP329A, ASP342F, ASP351F, ASP429A, ASP455A, ASP455F, ASP466F, ASP474A, ASP484A, ASP495F, ASP499F, ASP502F, CYS282A, CYS411F, GLN267F, GLN296A, GLN310A, GLN333A, GLN338A, GLN338F, GLN339F, GLN354F, GLN359F, GLN467A, GLN489A, GLN519F, GLN538F, GLN570A, GLU275F, GLU294A, GLU309A, GLU441A, GLU460A, GLU473A, GLU510A, GLU510F, GLU558A, GLU561A, GLU565A, GLY290A, GLY431A, GLY445A, GLY462A, GLY477A, GLY488A, GLY490A, GLY503F, HIS313A, HIS513A, HIS513F, ILE326A, ILE336A, ILE336F, ILE416F, ILE428A, ILE465F, ILE491F, ILE520F, ILE568A, ILE569A, LEU272F, LEU286A, LEU287A, LEU288A, LEU289A, LEU293A, LEU345A, LEU345F, LEU353F, LEU355F, LEU439A, LEU440A, LEU448A, LEU452A, LEU454A, LEU454F, LEU457A, LEU457F, LEU461A, LEU461F, LEU485A, LEU494F, LEU497F, LEU501F, LEU509F, LEU514A, LEU514F, LEU537F, LEU557A, LEU563A, LEU564A, LYS271F, LYS304A, LYS307A, LYS331A, LYS334A, LYS347F, LYS348F, LYS418F, LYS419F, LYS432A, LYS446A, LYS476A, LYS506F, LYS511A, LYS511F, LYS512A, LYS512F, LYS516A, LYS516F, LYS535F, LYS554A, LYS566A, MET278F, MET291A, MET412F, MET528A, PHE327A, PHE459A, PHE459F, PHE472A, PHE562A, PRO311A, PRO417F, PRO427A, PRO453A, PRO453F, PRO486A, PRO523F, PRO534F, SER269F, SER312A, SER330A, SER330F, SER352F, SER430A, SER487A, SER504F, THR274F, THR280A, THR335A, THR335F, THR343F, THR356F, THR433A, THR434A, THR518F, THR527A, THR536F, TRP270F, TYR276A, TYR292A, TYR297A, TYR414F, TYR500F, TYR531A, VAL268F, VAL285A, VAL341F, VAL344F, VAL350F, VAL413F, VAL450A, VAL463A, VAL470A, VAL471A, VAL475A, VAL505F, VAL507F, VAL533F
• B-C: ALA324C, ALA325C, ALA328C, ALA340B, ALA346B, ALA436C, ALA437C, ALA438C, ALA447C, ALA464C, ALA539B, ARG349B, ARG357B, ARG364C, ARG371C, ARG420B, ARG456B, ARG456C, ARG483C, ARG498B, ARG517B, ARG540B, ARG567C, ASN332B, ASN332C, ASN415B, ASN449C, ASN451C, ASN458B, ASN492B, ASN493B, ASN496B, ASN508B, ASN515B, ASN529C, ASP284C, ASP329C, ASP342B, ASP351B, ASP429C, ASP455B, ASP455C, ASP466B, ASP474C, ASP484C, ASP495B, ASP499B, ASP502B, GLN267B, GLN296C, GLN310C, GLN333C, GLN338B, GLN338C, GLN339B, GLN354B, GLN359B, GLN467C, GLN489C, GLN519B, GLN538B, GLN570C, GLU275B, GLU294C, GLU309C, GLU441C, GLU460C, GLU473C, GLU510B, GLU530C, GLU558C, GLU561C, GLU565C, GLY290C, GLY431C, GLY445C, GLY462C, GLY477C, GLY480C, GLY488C, GLY490C, GLY503B, HIS313C, HIS513B, HIS513C, ILE336B, ILE336C, ILE416B, ILE428C, ILE465B, ILE491B, ILE520B, ILE568C, ILE569C, LEU272B, LEU286C, LEU287C, LEU288C, LEU289C, LEU293C, LEU345B, LEU353B, LEU355B, LEU439C, LEU440C, LEU448C, LEU452C, LEU454B, LEU454C, LEU457B, LEU457C, LEU461B, LEU461C, LEU485C, LEU494B, LEU497B, LEU501B, LEU509B, LEU514B, LEU537B, LEU557C, LEU563C, LEU564C, LYS271B, LYS304C, LYS308C, LYS331C, LYS334C, LYS347B, LYS348B, LYS418B, LYS419B, LYS432C, LYS446C, LYS476C, LYS506B, LYS511B, LYS511C, LYS512B, LYS512C, LYS516B, LYS516C, LYS535B, LYS554C, LYS566C, MET278B, MET291C, MET528C, PHE327C, PHE459B, PHE459C, PHE472C, PHE521B, PHE562C, PRO311C, PRO417B, PRO427C, PRO453B, PRO453C, PRO486C, PRO522B, PRO523B, PRO534B, SER269B, SER312C, SER330C, SER352B, SER430C, SER482C, SER487C, SER504B, THR274B, THR335B, THR335C, THR343B, THR433C, THR434C, THR518B, THR527C, THR536B, TRP270B, TYR276C, TYR292C, TYR297C, TYR314C, TYR414B, TYR500B, TYR531C, VAL268B, VAL285C, VAL341B, VAL344B, VAL350B, VAL413B, VAL450B, VAL450C, VAL463C, VAL470C, VAL471C, VAL475C, VAL505B, VAL507B, VAL533B
• B-D: ARG456D, ASN458B, ASP455B, ASP455D, HIS513B, HIS513D
• B-F: ASP455B, ASP455F, HIS513B, HIS513F
• C-D: ALA324D, ALA325D, ALA328D, ALA340C, ALA346C, ALA436D, ALA437D, ALA438D, ALA447D, ALA464D, ALA539C, ARG349C, ARG357C, ARG364D, ARG371D, ARG420C, ARG456C, ARG456D, ARG483D, ARG498C, ARG517C, ARG540C, ARG567D, ASN332C, ASN332D, ASN415C, ASN449D, ASN451D, ASN458C, ASN492C, ASN493C, ASN496C, ASN508C, ASN515C, ASN529D, ASP283D, ASP284D, ASP329D, ASP342C, ASP351C, ASP429D, ASP455C, ASP455D, ASP466C, ASP474D, ASP484D, ASP495C, ASP499C, ASP502C, CYS337D, CYS411C, GLN267C, GLN296D, GLN310D, GLN333D, GLN338C, GLN338D, GLN339C, GLN354C, GLN359C, GLN467D, GLN489D, GLN519C, GLN538C, GLN570D, GLU275C, GLU294D, GLU309D, GLU441D, GLU460C, GLU460D, GLU473D, GLU510C, GLU510D, GLU558D, GLU561D, GLU565D, GLY290D, GLY431D, GLY444D, GLY445D, GLY462D, GLY477D, GLY488D, GLY490D, GLY503C, HIS313D, HIS513C, HIS513D, ILE326D, ILE336C, ILE336D, ILE416C, ILE428D, ILE465C, ILE491C, ILE520C, ILE568D, ILE569D, LEU272C, LEU286D, LEU287D, LEU288D, LEU289D, LEU293D, LEU345C, LEU345D, LEU353C, LEU355C, LEU439D, LEU440D, LEU448D, LEU452D, LEU454C, LEU454D, LEU457C, LEU457D, LEU461C, LEU461D, LEU485D, LEU494C, LEU497C, LEU501C, LEU509C, LEU514C, LEU514D, LEU537C, LEU557D, LEU563D, LEU564D, LYS271C, LYS304D, LYS331D, LYS334D, LYS347C, LYS348C, LYS418C, LYS419C, LYS432D, LYS446D, LYS476D, LYS506C, LYS511C, LYS511D, LYS512C, LYS512D, LYS516C, LYS516D, LYS535C, LYS554D, LYS566D, MET278C, MET291D, MET412C, MET528D, PHE327D, PHE459C, PHE459D, PHE472D, PHE562D, PRO311D, PRO417C, PRO427D, PRO453C, PRO453D, PRO486D, PRO523C, PRO534C, PRO549D, SER269C, SER312D, SER330D, SER352C, SER430D, SER487D, SER504C, THR274C, THR280D, THR335C, THR335D, THR343C, THR356C, THR433D, THR434D, THR518C, THR527D, THR536C, TRP270C, TYR276D, TYR292D, TYR297D, TYR414C, TYR500C, TYR531D, VAL268C, VAL285D, VAL341C, VAL344C, VAL350C, VAL413C, VAL450D, VAL463D, VAL470D, VAL471D, VAL475D, VAL505C, VAL507C, VAL533C
• C-E: ARG456C, ARG456E, ASP455C, ASP455E, PHE459C
• C-F: HIS513C, HIS513F
• D-E: ALA324E, ALA325E, ALA328E, ALA340D, ALA346D, ALA436E, ALA437E, ALA438E, ALA447E, ALA464E, ALA539D, ARG349D, ARG357D, ARG364E, ARG371E, ARG420D, ARG456D, ARG456E, ARG483E, ARG498D, ARG517D, ARG540D, ARG567E, ASN332D, ASN332E, ASN415D, ASN449E, ASN451E, ASN458D, ASN458E, ASN492D, ASN493D, ASN496D, ASN508D, ASN515D, ASN515E, ASN529E, ASP284E, ASP329E, ASP342D, ASP351D, ASP429E, ASP455D, ASP455E, ASP466D, ASP474E, ASP484E, ASP495D, ASP499D, ASP502D, CYS337E, GLN267D, GLN296E, GLN310E, GLN333E, GLN338D, GLN338E, GLN339D, GLN354D, GLN359D, GLN467E, GLN489E, GLN519D, GLN538D, GLN570E, GLU275D, GLU294E, GLU309E, GLU441E, GLU460E, GLU473E, GLU481E, GLU510D, GLU510E, GLU530E, GLU558E, GLU561E, GLU565E, GLY290E, GLY431E, GLY444E, GLY445E, GLY462E, GLY477E, GLY480E, GLY488E, GLY490E, GLY503D, HIS313E, HIS513D, HIS513E, ILE326E, ILE336D, ILE336E, ILE416D, ILE428E, ILE465D, ILE491D, ILE520D, ILE568E, ILE569E, LEU272D, LEU286E, LEU287E, LEU288E, LEU289E, LEU293E, LEU345D, LEU353D, LEU355D, LEU439E, LEU440E, LEU448E, LEU452E, LEU454D, LEU454E, LEU457D, LEU457E, LEU461D, LEU461E, LEU485E, LEU494D, LEU497D, LEU501D, LEU509D, LEU514D, LEU514E, LEU537D, LEU557E, LEU563E, LEU564E, LYS271D, LYS304E, LYS331E, LYS334E, LYS347D, LYS348D, LYS418D, LYS419D, LYS432E, LYS446E, LYS476E, LYS506D, LYS511D, LYS511E, LYS512D, LYS512E, LYS516D, LYS535D, LYS554E, LYS566E, MET278D, MET291E, MET528E, PHE327E, PHE459D, PHE459E, PHE472E, PHE521D, PHE562E, PRO311E, PRO417D, PRO427E, PRO453D, PRO453E, PRO486E, PRO522D, PRO523D, PRO534D, SER269D, SER312E, SER330E, SER352D, SER430E, SER482E, SER487E, SER504D, THR274D, THR335D, THR335E, THR343D, THR356D, THR433E, THR434E, THR518D, THR527E, THR536D, TRP270D, TYR276E, TYR292E, TYR297E, TYR314E, TYR414D, TYR500D, TYR531E, VAL268D, VAL285E, VAL341D, VAL344D, VAL350D, VAL413D, VAL450E, VAL463E, VAL471E, VAL475E, VAL505D, VAL507D, VAL533D
• D-F: ARG456F, ASP455D, ASP455F, HIS513D, HIS513F
• E-F: ALA325F, ALA328F, ALA340E, ALA346E, ALA436F, ALA437F, ALA438F, ALA447F, ALA464F, ALA539E, ARG349E, ARG357E, ARG364F, ARG371F, ARG420E, ARG456E, ARG456F, ARG483F, ARG498E, ARG517E, ARG540E, ARG567F, ASN332E, ASN332F, ASN415E, ASN449F, ASN451F, ASN458E, ASN492E, ASN493E, ASN496E, ASN508E, ASN515E, ASN529F, ASP284F, ASP329F, ASP342E, ASP351E, ASP429F, ASP455E, ASP455F, ASP466E, ASP474F, ASP484F, ASP495E, ASP499E, ASP502E, CYS282F, CYS337F, GLN267E, GLN296F, GLN310F, GLN333F, GLN338E, GLN339E, GLN354E, GLN359E, GLN467F, GLN489F, GLN519E, GLN538E, GLN570F, GLU275E, GLU294F, GLU309F, GLU441F, GLU460F, GLU473F, GLU510E, GLU510F, GLU530F, GLU558F, GLU561F, GLU565F, GLY290F, GLY431F, GLY445F, GLY477F, GLY480F, GLY488F, GLY490F, GLY503E, HIS313F, HIS513E, HIS513F, ILE326F, ILE336E, ILE336F, ILE416E, ILE428F, ILE465E, ILE465F, ILE491E, ILE520E, ILE568F, ILE569F, LEU272E, LEU286F, LEU287F, LEU288F, LEU289F, LEU293F, LEU345E, LEU345F, LEU353E, LEU355E, LEU439F, LEU440F, LEU448F, LEU452F, LEU454E, LEU454F, LEU457E, LEU457F, LEU461E, LEU461F, LEU485F, LEU494E, LEU497E, LEU501E, LEU509E, LEU514E, LEU537E, LEU557F, LEU563F, LEU564F, LYS271E, LYS304F, LYS307F, LYS331F, LYS334F, LYS347E, LYS348E, LYS418E, LYS419E, LYS432F, LYS446F, LYS476F, LYS506E, LYS511E, LYS511F, LYS512E, LYS512F, LYS516E, LYS516F, LYS535E, LYS554F, LYS566F, MET278E, MET291F, MET528F, PHE327F, PHE459E, PHE459F, PHE472F, PHE521E, PHE562F, PRO311F, PRO417E, PRO427F, PRO453E, PRO453F, PRO486F, PRO522E, PRO523E, PRO534E, SER269E, SER312F, SER330E, SER330F, SER352E, SER381F, SER430F, SER482F, SER487F, SER504E, THR274E, THR335E, THR335F, THR343E, THR356E, THR433F, THR434F, THR518E, THR527F, THR536E, TRP270E, TYR276F, TYR292F, TYR297F, TYR314F, TYR414E, TYR500E, TYR531F, VAL268E, VAL285F, VAL341E, VAL344E, VAL350E, VAL450F, VAL463F, VAL470F, VAL471F, VAL475F, VAL505E, VAL507E, VAL533E