1SUV

structure of human transferrin receptor-transferrin complex

• Total interactions analyzed: 15
• Total true interactions: 12
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 268
  • Norm. En. per Res.: -3.3229
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-66.9772	-71.1222	-752.437	-890.5364	268	37	11	30126	8	78	82
A-C	-34.9331	-16.41	1216.36	1165.017	65	131	3	5479	0	31	35
A-D	0.0	0.0	-2.6533	-2.6533	18	0	0	279	0	0	2
A-E	-116.0838	-90.9346	871.987	664.9686	95	205	1	8078	9	36	35
A-F	0.0	0.0	-0.0023	-0.0023	2	0	0	3	0	0	3
B-C	0.0	0.0	-2.4186	-2.4186	18	0	0	281	0	0	2
B-D	-48.9811	-6.8491	776.634	720.8038	65	131	3	5523	0	31	34
B-E	0.0	0.0	-0.0023	-0.0023	2	0	0	3	0	0	3
B-F	-125.702	-100.2207	894.632	668.7093	93	195	1	7560	10	34	33
C-D	0.0	0.0	-1.6502	-1.6502	12	0	0	123	0	4	6
C-E	-44.6249	-17.3905	330.83	268.8146	71	73	1	6024	0	21	22
D-F	-44.5371	-17.3943	328.592	266.6605	71	73	1	6023	0	21	22

Interface residues

• A-B: ALA478A, ALA478B, ALA736A, ALA736B, ALA738A, ALA738B, ALA745A, ALA745B, ALA746A, ALA746B, ALA748A, ALA748B, ARG174A, ARG174B, ARG183A, ARG183B, ARG446A, ARG446B, ARG668A, ARG668B, ARG677A, ARG677B, ARG680A, ARG680B, ARG698A, ARG698B, ARG732A, ARG732B, ASN317A, ASN317B, ASN388A, ASN388B, ASN675A, ASN675B, ASN733A, ASN733B, ASN747A, ASN747B, ASN758A, ASN758B, ASP184A, ASP184B, ASP400A, ASP400B, ASP648A, ASP667A, ASP667B, ASP676A, ASP676B, ASP752A, ASP752B, ASP755A, ASP755B, ASP757A, ASP757B, GLN185A, GLN185B, GLN320A, GLN320B, GLN640A, GLN640B, GLN734A, GLN734B, GLN743A, GLN743B, GLU170A, GLU170B, GLU398A, GLU398B, GLU465A, GLU465B, GLU468A, GLU468B, GLU664A, GLU664B, GLU694A, GLU694B, GLU759A, GLU759B, GLY312A, GLY312B, GLY391A, GLY391B, GLY469A, GLY469B, GLY636A, GLY636B, GLY744A, GLY744B, GLY751A, GLY751B, HIS186A, HIS186B, HIS318A, HIS318B, HIS401A, HIS401B, HIS475A, HIS475B, HIS684A, HIS684B, HIS707A, HIS707B, ILE389A, ILE389B, ILE393A, ILE393B, ILE448A, ILE448B, ILE449A, ILE449B, ILE550A, ILE550B, ILE632A, ILE632B, ILE756A, ILE756B, LEU387A, LEU387B, LEU467A, LEU467B, LEU471A, LEU471B, LEU474A, LEU474B, LEU476A, LEU476B, LEU637A, LEU637B, LEU639A, LEU639B, LEU642A, LEU642B, LEU674A, LEU674B, LEU686A, LEU686B, LEU730A, LEU730B, LEU735A, LEU735B, LEU737A, LEU737B, LEU749A, LEU749B, LYS180A, LYS180B, LYS385A, LYS385B, LYS394A, LYS394B, LYS477A, LYS477B, LYS672A, LYS672B, LYS673A, LYS673B, LYS693A, LYS693B, MET635A, MET635B, MET671A, MET671B, PHE187A, PHE187B, PHE313A, PHE313B, PHE316A, PHE316B, PHE321A, PHE321B, PHE390A, PHE390B, PHE479A, PHE479B, PHE544A, PHE544B, PHE669A, PHE669B, PHE685A, PHE685B, PHE731A, PHE731B, PHE760A, PHE760B, PRO311A, PRO311B, PRO314A, PRO314B, PRO322A, PRO322B, PRO323A, PRO323B, PRO399A, PRO399B, PRO688A, PRO688B, PRO692A, PRO692B, SER315A, SER315B, SER447A, SER447B, SER472A, SER472B, SER473A, SER473B, SER638A, SER638B, SER687A, SER687B, SER691A, SER691B, SER706A, SER706B, SER750A, SER750B, THR310A, THR310B, THR319A, THR319B, THR480B, THR729A, THR729B, THR739A, THR739B, THR741A, THR741B, TRP182A, TRP182B, TRP453A, TRP453B, TRP466A, TRP466B, TRP641A, TRP641B, TRP740A, TRP740B, TRP754A, TRP754B, TYR402A, TYR402B, TYR470A, TYR470B, TYR547A, TYR547B, TYR683A, TYR683B, TYR689A, TYR689B, VAL181A, VAL181B, VAL392A, VAL392B, VAL397A, VAL397B, VAL403A, VAL403B, VAL404A, VAL404B, VAL605A, VAL605B, VAL670A, VAL670B, VAL690A, VAL690B, VAL753A, VAL753B
• A-C: ALA149C, ALA311C, ALA663A, ALA70C, ALA73C, ARG129A, ARG143C, ARG324C, ARG327C, ARG50C, ARG668A, ASN152C, ASN608A, ASN662A, ASN75C, ASN76C, ASP125A, ASP126A, ASP166C, ASP310C, ASP604A, ASP659A, ASP667A, ASP69C, GLN443A, GLU141C, GLU147C, GLU328C, GLU606A, GLU664A, GLY661A, HIS603A, ILE49C, LEU122A, LEU127A, LEU146C, LEU170C, LEU46C, LEU674A, LEU72C, LYS128A, LYS144C, LYS148C, LYS312C, LYS508A, LYS600A, LYS665A, MET671A, PHE167C, PHE660A, PHE669A, PRO140C, PRO142C, PRO145C, PRO74C, THR330C, THR658A, THR666A, TRP124A, TYR123A, TYR68C, TYR71C, VAL150C, VAL605A, VAL670A
• A-D: ALA53D, ALA54D, ALA73D, ARG50D, ARG668A, ASN55D, ASN75D, GLN443A, GLY395A, LEU438A, LYS180A, LYS394A, MET256D, PHE396A, PRO399A, PRO74D, SER179A, VAL437A
• A-E: ALA341E, ALA346E, ALA371E, ALA529A, ALA630A, ALA645A, ARG352E, ARG508E, ARG623A, ARG629A, ARG646A, ARG651A, ARG655A, ASN506E, ASN527A, ASN615A, ASN626A, ASN758A, ASP333E, ASP337E, ASP356E, ASP376E, ASP525A, ASP624A, ASP648A, ASP757A, CYS355E, CYS368E, GLN627A, GLN640A, GLU338E, GLU357E, GLU367E, GLU369E, GLU372E, GLU385E, GLU759A, GLY348E, GLY363E, GLY364E, GLY499E, GLY647A, HIS349E, HIS350E, ILE366E, ILE756A, LEU335E, LEU347E, LEU353E, LEU365E, LEU618A, LEU619A, LEU625A, LEU639A, LEU642A, LYS340E, LYS343E, LYS354E, LYS380E, LYS622E, LYS633A, PHE616E, PHE621A, PHE650A, PHE760A, PRO500E, SER359E, SER362E, SER370E, SER501E, SER526A, SER530A, SER613E, SER614E, SER616A, SER620A, SER638A, SER644A, SER654A, THR361E, THR373E, THR653A, THR657A, THR658A, TRP344E, TRP358E, TRP528A, TRP641A, TYR523A, TYR628A, TYR643A, VAL360E, VAL498E, VAL502E, VAL622A
• A-F: GLN185A, PRO500F
• B-C: ALA53C, ALA54C, ALA73C, ARG50C, ARG668B, ASN55C, ASN75C, GLN443B, GLY395B, LEU438B, LYS180B, LYS394B, MET256C, PHE396B, PRO399B, PRO74C, SER179B, VAL437B
• B-D: ALA149D, ALA311D, ALA663B, ALA70D, ALA73D, ARG129B, ARG143D, ARG324D, ARG327D, ARG50D, ARG668B, ASN152D, ASN608B, ASN662B, ASN75D, ASN76D, ASP125B, ASP126B, ASP166D, ASP310D, ASP604B, ASP659B, ASP667B, ASP69D, GLN443B, GLU141D, GLU147D, GLU328D, GLU606B, GLU664B, GLY661B, HIS603B, ILE49D, LEU122B, LEU127B, LEU146D, LEU170D, LEU46D, LEU674B, LEU72D, LYS128B, LYS144D, LYS148D, LYS312D, LYS508B, LYS600B, LYS665B, MET671B, PHE167D, PHE660B, PHE669B, PRO140D, PRO142D, PRO145D, PRO74D, THR330D, THR658B, THR666B, TRP124B, TYR123B, TYR68D, TYR71D, VAL150D, VAL605B, VAL670B
• B-E: GLN185B, PRO500E
• B-F: ALA341F, ALA346F, ALA371F, ALA529B, ALA630B, ALA645B, ARG352F, ARG508F, ARG623B, ARG629B, ARG646B, ARG651B, ARG655B, ASN506F, ASN527B, ASN615B, ASN626B, ASN758B, ASP333F, ASP337F, ASP356F, ASP376F, ASP525B, ASP624B, ASP648B, ASP757B, CYS355F, CYS368F, GLN627B, GLN640B, GLU338F, GLU357F, GLU367F, GLU369F, GLU372F, GLU385F, GLU759B, GLY348F, GLY363F, GLY364F, GLY499F, GLY647B, HIS349F, HIS350F, ILE366F, ILE756B, LEU335F, LEU347F, LEU353F, LEU365F, LEU618B, LEU619B, LEU625B, LEU639B, LEU642B, LYS340F, LYS343F, LYS354F, LYS380F, LYS622F, LYS633B, PHE616F, PHE621B, PHE650B, PHE760B, PRO500F, SER359F, SER362F, SER370F, SER501F, SER526B, SER530B, SER613F, SER614F, SER616B, SER620B, SER638B, SER644B, SER654B, THR361F, THR373F, THR653B, THR657B, THR658B, TRP358F, TRP528B, TRP641B, TYR523B, TYR643B, VAL360F, VAL498F, VAL502F, VAL622B
• C-D: ARG7C, ARG7D, ASN55C, ASN55D, ASP163C, ASP163D, ASP166C, ASP166D, GLU56C, GLU56D, THR165C, THR165D
• C-E: ALA311C, ALA379E, ALA64C, ALA670E, ALA82C, ARG308C, ARG324C, ARG587E, ARG666E, ASN383E, ASP310C, ASP333E, ASP376E, ASP90C, CYS137C, CYS331C, CYS402E, CYS671E, GLN245C, GLN488E, GLN92C, GLU318C, GLU375E, GLU385E, GLU669E, GLU83C, GLY316C, GLY384E, GLY403E, HIS242C, HIS249C, HIS674E, HIS676E, ILE381E, LEU303C, LEU315C, LEU667E, LEU668E, LYS304C, LYS312C, LYS380E, LYS675E, MET309C, MET313C, MET382E, PHE673E, PHE84C, PHE94C, PRO247C, PRO306C, PRO307C, PRO332E, PRO79C, PRO91C, SER125C, SER248C, SER665E, THR250C, THR321C, THR330C, THR672E, THR93C, TYR314C, TYR317C, TYR319C, TYR85C, TYR95C, TYR96C, VAL246C, VAL305C, VAL320C
• D-F: ALA311D, ALA379F, ALA64D, ALA670F, ALA82D, ARG308D, ARG324D, ARG587F, ARG666F, ASN383F, ASP310D, ASP333F, ASP376F, ASP90D, CYS137D, CYS331D, CYS402F, CYS671F, GLN245D, GLN488F, GLN92D, GLU318D, GLU375F, GLU385F, GLU669F, GLU83D, GLY316D, GLY384F, GLY403F, HIS242D, HIS249D, HIS674F, HIS676F, ILE381F, LEU303D, LEU315D, LEU667F, LEU668F, LYS304D, LYS312D, LYS380F, LYS675F, MET309D, MET313D, MET382F, PHE673F, PHE84D, PHE94D, PRO247D, PRO306D, PRO307D, PRO332F, PRO79D, PRO91D, SER125D, SER248D, SER665F, THR250D, THR321D, THR330D, THR672F, THR93D, TYR314D, TYR317D, TYR319D, TYR85D, TYR95D, TYR96D, VAL246D, VAL305D, VAL320D