1SQB

crystal structure analysis of bovine bc1 with azoxystrobin

• Total interactions analyzed: 55
• Total true interactions: 30
• Strongest Interaction:
  • Chains: A-G
  • Int. Res.: 70
  • Norm. En. per Res.: -7.025
• Hub Node: A(9)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-127.0216	-91.1565	-592.671	-810.849	228	27	12	22495	8	54	53
A-C	-44.0149	-35.4333	-83.9731	-163.4213	51	7	0	3436	4	19	16
A-D	-3.0677	5.2267	-23.6888	-21.5298	36	1	1	1288	0	9	12
A-E	-72.2261	-17.5276	-258.01	-347.7637	112	20	4	10236	3	32	30
A-F	0.0	2.9346	-0.3637	2.5709	10	0	0	107	0	9	9
A-G	-135.3662	-59.3841	-297.0	-491.7503	70	15	2	9627	2	20	12
A-I	-35.3651	-30.7808	-325.704	-391.8499	133	13	4	13587	4	22	33
A-J	-26.3147	-6.5121	-73.3925	-106.2192	31	5	0	2417	0	4	6
A-K	0.0	-8.0591	-91.5229	-99.582	39	5	0	3592	0	9	7
B-I	-55.9538	-10.4718	-533.657	-600.0826	201	35	17	23009	2	18	23
B-K	0.0	0.0	-0.001	-0.001	2	0	0	3	0	0	1
C-D	-37.1976	-79.5132	-463.12	-579.8308	155	16	10	17799	9	37	38
C-E	-31.9612	3.9947	-131.119	-159.0855	52	8	1	4904	1	3	1
C-F	-29.9609	25.2844	-339.946	-344.6225	113	8	6	13590	2	38	31
C-G	-11.3403	-39.8212	-283.237	-334.3985	114	6	7	10375	3	18	14
C-J	0.0	0.0	-0.0005	-0.0005	2	0	0	1	0	0	0
D-E	0.0	-30.4468	-153.372	-183.8188	103	7	4	6833	1	24	31
D-F	-27.241	-10.1743	-99.0195	-136.4348	37	5	1	3675	1	9	13
D-G	-71.0448	-3.0687	-207.315	-281.4284	59	13	5	7488	0	14	15
D-H	-29.8509	0.7708	-272.314	-301.3941	106	8	6	11995	0	20	27
D-I	0.0	0.0	-0.0147	-0.0147	2	0	0	3	0	1	0
D-J	-42.6465	-47.6846	-242.09	-332.421	78	10	5	8811	3	42	38
E-F	0.0	0.0	-0.3622	-0.3622	4	0	0	48	0	1	0
E-G	-54.9706	-61.6375	-173.163	-289.7711	46	11	4	6028	2	11	14
E-J	-8.5225	-21.9807	-188.727	-219.2302	61	3	14	6832	2	6	7
E-K	-8.1478	-13.7278	-33.5814	-55.457	22	1	0	1010	2	1	0
F-G	-19.7224	-57.3558	-84.8603	-161.9385	53	4	2	3513	4	11	24
G-H	-4.7302	-51.3709	-21.5282	-77.6292	19	0	0	775	3	19	7
G-J	0.0	0.0	-0.0054	-0.0054	2	0	0	5	0	0	0
J-K	-5.5542	16.0016	-143.246	-132.7987	54	5	9	6234	0	6	4

Interface residues

• A-B: ALA101A, ALA149B, ALA151B, ALA15B, ALA200A, ALA275A, ALA281B, ALA288A, ALA291B, ALA295A, ALA2A, ALA359B, ALA360B, ALA364A, ALA366B, ALA42B, ALA44B, ALA5A, ALA63A, ALA72B, ALA74A, ALA7A, ALA84A, ALA88A, ALA91B, ALA96A, ARG113B, ARG287B, ARG356A, ARG362A, ARG46B, ARG87B, ASN141A, ASN290B, ASN359A, ASN362B, ASN363A, ASN40B, ASN73A, ASN87A, ASP105A, ASP114B, ASP115B, ASP147B, ASP281A, ASP356B, ASP370A, CYS111B, CYS282A, CYS35A, GLN126A, GLN136A, GLN143B, GLN15A, GLN22B, GLN297B, GLN29A, GLN305A, GLN32A, GLN358B, GLN6A, GLN9A, GLU110B, GLU130A, GLU136B, GLU137A, GLU13A, GLU168A, GLU204A, GLU28A, GLU353A, GLU373B, GLU376B, GLU396A, GLU39B, GLU60A, GLU76A, GLU78A, GLU80A, GLU90B, GLY16B, GLY201A, GLY202A, GLY210B, GLY278A, GLY280B, GLY282B, GLY285A, GLY286A, GLY287A, GLY288B, GLY357A, GLY367B, GLY371A, GLY377B, GLY56A, GLY72A, GLY83A, GLY88B, GLY93B, GLY94B, HIS205A, HIS20B, HIS277B, HIS279A, HIS284B, HIS289A, HIS368A, HIS61A, HIS85A, ILE116A, ILE134A, ILE146B, ILE399A, ILE85B, ILE89B, ILE99A, LEU102A, LEU112B, LEU119B, LEU140B, LEU203A, LEU209B, LEU290A, LEU355A, LEU360A, LEU361A, LEU364B, LEU365A, LEU369A, LEU369B, LEU392A, LEU399B, LEU62A, LEU71B, LEU75A, LEU75B, LEU86A, LEU8A, LEU96B, LYS100A, LYS104A, LYS148B, LYS286B, LYS302A, LYS358A, LYS361B, LYS363B, LYS365B, LYS65A, LYS77A, LYS84B, LYS95B, MET370B, MET82A, PHE378B, PHE58A, PHE64A, PHE83B, PRO12A, PRO142B, PRO18B, PRO19B, PRO21B, PRO283B, PRO293A, PRO306B, PRO33A, PRO355B, PRO374A, PRO395B, PRO43B, SER103A, SER10A, SER212B, SER27A, SER289B, SER291A, SER292A, SER293B, SER296A, SER30A, SER31A, SER352A, SER367A, SER371B, SER374B, SER375B, SER396B, SER45B, SER73B, SER74B, SER81A, SER81B, SER82B, SER90A, THR14A, THR1A, THR283A, THR292B, THR34A, THR36A, THR372A, THR373A, THR3A, THR76B, THR86B, TYR280A, TYR284A, TYR368B, TYR41B, TYR4A, TYR57A, TYR89A, TYR97A, TYR98A, VAL11A, VAL133A, VAL150B, VAL17B, VAL211B, VAL215B, VAL285B, VAL366A, VAL372B, VAL375A, VAL79A, VAL92B
• A-C: ARG244A, ARG436A, ARG438A, ARG445A, ARG5C, ASN15C, ASN301A, ASN3C, ASN435A, ASP20C, ASP214C, ASP216C, ASP332A, ASP333A, ASP433A, GLN339A, GLN430A, GLU429A, HIS221C, ILE19C, ILE218C, ILE226C, ILE297A, ILE331A, ILE437A, ILE4C, LEU21C, LEU303A, LEU431A, LEU444A, LYS217C, LYS6C, MET329A, MET334A, MET335A, PHE18C, PHE220C, PHE336A, PHE442A, PRO219C, PRO222C, PRO22C, PRO432A, SER330A, SER439A, THR225C, THR2C, TYR223C, TYR434A, VAL215C, VAL337A
• A-D: ALA236D, ARG233D, ARG238D, ARG244A, ARG436A, ARG438A, ASN435A, ASP142A, ASP433A, CYS242A, GLN136A, GLN139A, GLN240A, GLU245A, HIS225D, HIS243A, ILE241A, LEU230D, LEU235D, LYS223D, LYS226D, LYS231D, LYS234D, LYS241D, PHE442A, PRO239D, PRO240D, SER171A, SER228D, SER239A, SER439A, TRP227D, TYR152A, TYR237D, TYR434A, VAL229D
• A-E: ALA155A, ALA157A, ALA164A, ARG146A, ARG14E, ARG15E, ARG175A, ARG235A, ARG32E, ARG438A, ARG46A, ARG92A, ASN141A, ASN151A, ASN173A, ASN53A, ASP142A, ASP147A, ASP20E, ASP316A, ASP417A, ASP4E, ASP9E, CYS234A, CYS242A, CYS419A, GLN136A, GLN139A, GLN159A, GLN165A, GLN240A, GLN418A, GLU137A, GLU140A, GLU168A, GLU172A, GLU17E, GLU258A, GLU27E, GLU30E, GLU50A, GLY160A, GLY169A, GLY238A, GLY259A, GLY318A, HIS154A, HIS243A, HIS264A, HIS2E, ILE134A, ILE241A, ILE5E, LEU135A, LEU138A, LEU153A, LEU19E, LEU231A, LEU270A, LEU320A, LYS23E, LYS26E, LYS33E, LYS413A, LYS6E, MET145A, MET441A, PHE10E, PHE150A, PHE158A, PHE236A, PHE415A, PHE425A, PHE442A, PRO162A, PRO170A, PRO233A, PRO260A, PRO420A, PRO8E, SER11E, SER144A, SER166A, SER171A, SER1E, SER21E, SER232A, SER239A, SER24E, SER25E, SER28E, SER29E, SER412A, SER439A, THR143A, THR156A, THR161A, THR22E, THR237A, THR317A, THR3E, TYR152A, TYR37E, TYR414A, TYR416A, VAL148A, VAL149A, VAL167A, VAL174A, VAL18E, VAL257A, VAL7E
• A-F: ARG244A, ASP246A, ASP56F, CYS242A, GLU245A, GLU52F, GLY247A, LYS63F, TYR55F, VAL59F
• A-G: ALA155A, ALA421A, ARG11G, ARG235A, ARG244A, ARG2G, ARG436A, ARG438A, ARG9G, ASN435A, ASP246A, ASP327A, ASP332A, ASP417A, ASP433A, CYS242A, CYS419A, GLN159A, GLN23G, GLN240A, GLN3G, GLN418A, GLN430A, GLU22G, GLU245A, GLU429A, GLY238A, GLY247A, GLY424A, GLY426A, GLY5G, HIS12G, HIS243A, HIS328A, HIS6G, ILE14G, ILE241A, ILE331A, ILE428A, LEU18G, LEU248A, LEU431A, LEU7G, MET329A, MET441A, PHE21G, PHE236A, PHE425A, PHE442A, PHE4G, PRO20G, PRO249A, PRO420A, PRO427A, PRO432A, SER17G, SER19G, SER239A, SER330A, SER439A, THR156A, THR15G, THR237A, THR8G, TYR152A, TYR16G, TYR434A, VAL10G, VAL13G, VAL422A
• A-I: ALA17I, ALA251A, ALA275A, ALA322A, ALA32I, ALA33I, ALA364A, ALA36I, ARG146A, ARG20I, ARG362A, ARG381A, ARG389A, ARG398A, ARG47I, ARG52I, ARG56I, ASN141A, ASN267A, ASN274A, ASN311A, ASN359A, ASN363A, ASP132A, ASP142A, ASP147A, ASP281A, ASP327A, ASP378A, ASP44I, CYS282A, CYS313A, CYS326A, CYS376A, CYS51I, GLN136A, GLN139A, GLN271A, GLN305A, GLN308A, GLN31I, GLU130A, GLU137A, GLU140A, GLU377A, GLU39I, GLU53I, GLU80A, GLY21I, GLY247A, GLY278A, GLY285A, GLY286A, GLY287A, GLY380A, GLY57I, HIS252A, HIS279A, HIS323A, HIS368A, HIS61A, HIS85A, HIS94A, ILE134A, ILE312A, ILE379A, ILE390A, ILE399A, LEU135A, LEU138A, LEU15I, LEU248A, LEU250A, LEU26I, LEU290A, LEU360A, LEU361A, LEU365A, LEU369A, LEU383A, LEU384A, LEU43I, LEU45I, LEU50I, LEU55I, LYS46I, LYS65A, MET145A, PHE150A, PHE307A, PHE310A, PHE324A, PHE425A, PRO249A, PRO35I, PRO374A, PRO41I, SER144A, SER16I, SER19I, SER291A, SER292A, SER306A, SER367A, SER382A, SER38I, SER40I, SER48I, SER54I, THR143A, THR18I, THR283A, THR309A, THR37I, THR385A, TRP262A, TRP395A, TRP40A, TYR280A, TYR284A, TYR386A, TYR89A, VAL133A, VAL149A, VAL14I, VAL22I, VAL268A, VAL325A, VAL34I, VAL366A, VAL375A, VAL42I, VAL49I
• A-J: ALA21J, ARG15J, ARG16J, ARG408A, ARG438A, ARG445A, ASP417A, CYS346A, CYS411A, CYS419A, GLN418A, GLU409A, LEU444A, LYS413A, MET343A, MET441A, PHE14J, PHE20J, PHE415A, PHE442A, PHE446A, SER18J, SER412A, THR17J, THR19J, THR347A, TRP443A, TYR10J, TYR414A, TYR416A, VAL410A
• A-K: ALA14K, ALA21K, ALA349A, ALA404A, ARG11K, ARG15K, ARG344A, ARG356A, ARG405A, ARG408A, ARG445A, ARG9K, ASN16K, ASP403A, GLN12K, GLU351A, GLU353A, LEU13K, LEU23K, LEU345A, LEU355A, LEU444A, MET343A, PHE446A, PRO19K, PRO293A, PRO8K, SER348A, SER352A, THR20K, THR347A, THR350A, TRP17K, TRP24K, TRP443A, TYR10K, TYR416A, VAL18K, VAL354A
• B-I: ALA106B, ALA12I, ALA149B, ALA151B, ALA157B, ALA17I, ALA23I, ALA255B, ALA256B, ALA25I, ALA262B, ALA263B, ALA267B, ALA269B, ALA271B, ALA281B, ALA311B, ALA314B, ALA32I, ALA33I, ALA36I, ALA386B, ALA388B, ALA389B, ALA5I, ALA6I, ALA72B, ARG102B, ARG145B, ARG20I, ARG27I, ARG287B, ARG47I, ARG52I, ARG70B, ARG7I, ARG87B, ASN104B, ASN154B, ASN270B, ASN290B, ASN313B, ASP147B, ASP250B, ASP308B, ASP380B, ASP44I, GLN143B, GLN153B, GLN156B, GLN276B, GLN305B, GLN31I, GLN329B, GLN385B, GLN401B, GLU103B, GLU110B, GLU161B, GLU268B, GLU376B, GLU381B, GLU39I, GLU53I, GLU90B, GLY21I, GLY24I, GLY265B, GLY280B, GLY282B, GLY288B, GLY320B, GLY367B, GLY377B, GLY383B, GLY390B, GLY93B, GLY94B, GLY9I, HIS158B, HIS164B, HIS254B, HIS277B, HIS284B, HIS304B, HIS67B, ILE146B, ILE160B, ILE264B, ILE327B, ILE402B, ILE85B, ILE89B, LEU140B, LEU144B, LEU152B, LEU15I, LEU163B, LEU172B, LEU176B, LEU252B, LEU26I, LEU279B, LEU295B, LEU29I, LEU2I, LEU321B, LEU364B, LEU369B, LEU387B, LEU399B, LEU43I, LEU45I, LEU55I, LEU68B, LEU69B, LEU71B, LEU96B, LYS148B, LYS286B, LYS365B, LYS46I, LYS95B, MET105B, MET1I, PHE11I, PHE272B, PHE307B, PHE312B, PHE324B, PHE50B, PRO10I, PRO13I, PRO155B, PRO283B, PRO28I, PRO306B, PRO35I, PRO394B, PRO395B, PRO41I, SER100B, SER16I, SER175B, SER19I, SER251B, SER266B, SER273B, SER289B, SER293B, SER310B, SER315B, SER317B, SER328B, SER371B, SER384B, SER38I, SER391B, SER3I, SER40I, SER48I, SER55B, SER66B, SER73B, SER74B, SER8I, SER97B, THR101B, THR108B, THR18I, THR326B, THR37I, THR393B, THR397B, THR86B, THR99B, TYR107B, TYR177B, TYR296B, TYR316B, TYR325B, TYR368B, TYR392B, VAL126B, VAL14I, VAL150B, VAL159B, VAL22I, VAL274B, VAL285B, VAL309B, VAL30I, VAL34I, VAL372B, VAL382B, VAL398B, VAL405B, VAL42I, VAL49I, VAL4I, VAL98B
• B-K: ARG87B, ARG9K
• C-D: ALA119D, ALA193D, ALA194D, ALA221D, ALA232C, ALA238C, ALA23C, ALA246C, ALA47D, ARG102D, ARG118D, ARG120D, ARG15D, ARG191D, ARG201D, ARG203D, ARG224D, ARG233D, ARG49D, ARG71C, ARG80C, ASN255C, ASN260C, ASN263C, ASN26C, ASN32C, ASN74C, ASP112D, ASP199D, ASP216C, ASP228C, ASP248C, ASP252C, ASP254C, ASP2D, ASP44D, ASP72C, CYS70C, GLN137C, GLU195D, GLU197D, GLU344C, GLU4D, GLY122D, GLY123D, GLY16D, GLY205D, GLY213D, GLY231C, GLY251C, HIS121D, HIS198D, HIS200D, HIS221C, HIS225D, HIS267C, HIS50D, HIS68C, ILE116D, ILE218C, ILE226C, ILE229C, ILE236C, ILE27C, ILE69C, ILE78C, LEU109D, LEU113D, LEU17D, LEU18D, LEU190D, LEU206D, LEU209D, LEU210D, LEU214D, LEU215D, LEU216D, LEU218D, LEU230C, LEU230D, LEU233C, LEU234C, LEU235C, LEU235D, LEU237C, LEU239C, LEU241C, LEU242C, LEU244C, LEU249C, LEU262C, LYS202D, LYS207D, LYS217C, LYS223D, LYS226D, LYS227C, LYS231D, LYS269C, MET204D, MET208D, MET211D, MET212D, MET222D, MET240C, MET43D, PHE189D, PHE220C, PHE245C, PHE63C, PHE91D, PRO111D, PRO154D, PRO196D, PRO217D, PRO219C, PRO222C, PRO247C, PRO24C, PRO253C, PRO258C, PRO266C, PRO98D, SER114D, SER19D, SER228D, SER25C, SER29C, SER64C, SER65C, THR225C, THR257C, THR60C, THR61C, THR67C, TRP192D, TRP227D, TRP77C, TYR115D, TYR220D, TYR223C, TYR224C, TYR256C, TYR45D, TYR75C, TYR81C, TYR90D, VAL117D, VAL215C, VAL219D, VAL229D, VAL243C, VAL46D, VAL66C, VAL73C
• C-E: ALA50E, ALA64E, ALA66E, ARG71C, ASN53E, ASN74C, ASP67E, ASP72C, GLN57E, GLY46E, GLY48C, GLY76C, HIS54C, HIS68C, HIS83C, ILE226C, ILE229C, ILE236C, ILE45C, ILE69C, ILE78C, ILE79C, LEU233C, LEU239C, LEU244C, LEU43C, LEU46C, LEU49C, LEU51C, LEU69E, MET240C, MET53C, MET62E, MET82C, PHE50C, PHE58E, SER56E, SER60E, SER61E, SER63E, SER65E, THR40E, THR43E, THR47C, TRP77C, TYR75C, VAL47E, VAL54E, VAL55E, VAL59E, VAL68E, VAL73C
• C-F: ALA23F, ALA24F, ALA369C, ALA65F, ARG17F, ARG313C, ARG318C, ARG33F, ARG58F, ARG61F, ARG64F, ARG71F, ASN206C, ASN207C, ASN22F, ASN26C, ASN27F, ASN374C, ASN40F, ASP214C, ASP216C, ASP34F, ASP35F, ASP42F, ASP67F, ASP86F, GLN312C, GLN322C, GLN72F, GLN73F, GLU14F, GLU373C, GLU39F, GLU84F, GLU91F, GLY105C, GLY15F, GLY210C, GLY25F, GLY370C, HIS308C, HIS38F, ILE16F, ILE211C, ILE218C, ILE27C, ILE372C, ILE37F, ILE47F, ILE62F, ILE74F, ILE98F, LEU110C, LEU13F, LEU29F, LEU31F, LEU320C, LEU376C, LEU377C, LEU66F, LEU68F, LEU90F, LEU94F, LYS18F, LYS217C, LYS227C, LYS28F, LYS311C, LYS375C, LYS378C, LYS44F, LYS63F, LYS95F, MET315C, MET316C, MET32F, MET70F, PHE109C, PHE26F, PHE317C, PHE60F, PRO208C, PRO24C, PRO319C, SER106C, SER212C, SER213C, SER25C, SER28C, SER29C, SER310C, SER314C, SER321C, SER69F, SER88F, THR108C, THR203C, THR209C, THR36F, TRP19F, TRP30C, TRP31C, TRP379C, TYR104C, TYR20F, TYR21F, TYR223C, TYR224C, TYR55F, TYR83F, VAL215C, VAL43F, VAL59F
• C-G: ALA23C, ALA327C, ALA330C, ALA354C, ALA43G, ALA49G, ALA54G, ARG11G, ARG2G, ARG318C, ARG40G, ARG47G, ARG9G, ASN15C, ASN16C, ASP20C, ASP214C, ASP216C, ASP331C, CYS323C, CYS44G, GLN322C, GLN341C, GLN3G, GLN64G, GLU202C, GLU344C, GLU373C, GLU65G, GLU67G, GLY1G, GLY204C, GLY351C, GLY5G, GLY62G, HIS201C, HIS221C, HIS345C, HIS6G, ILE19C, ILE218C, ILE338C, ILE348C, ILE350C, ILE45G, LEU198C, LEU200C, LEU21C, LEU320C, LEU324C, LEU328C, LEU332C, LEU333C, LEU335C, LEU353C, LEU357C, LEU361C, LEU46G, LEU57G, LEU7G, LYS217C, LYS68G, LYS6C, LYS70G, MET315C, MET316C, PHE220C, PHE317C, PHE325C, PHE4G, PHE52G, PHE55G, PHE66G, PRO20G, PRO219C, PRO222C, PRO22C, PRO24C, PRO319C, PRO342C, PRO346C, PRO50G, PRO51G, SER17G, SER212C, SER213C, SER28C, SER29C, SER321C, SER69G, THR15G, THR203C, THR334C, THR336C, THR349C, THR60G, THR63G, THR8G, TRP326C, TRP337C, TRP61G, TYR103C, TYR223C, TYR347C, TYR56G, TYR59G, VAL10G, VAL13G, VAL215C, VAL329C, VAL343C, VAL48G, VAL53G, VAL58G
• C-J: PHE245C, TYR43J
• D-E: ALA221D, ALA236D, ALA41E, ALA47D, ALA48E, ALA50E, ALA51E, ALA66E, ALA70E, ALA88E, ARG14E, ARG15E, ARG224D, ARG233D, ARG238D, ARG32E, ARG49D, ARG83D, ASN53E, ASN75D, ASP12E, ASP4E, ASP67E, ASP72D, ASP80E, ASP89D, ASP9E, GLN57E, GLU58D, GLU75E, GLU76D, GLY46E, HIS200D, HIS225D, HIS2E, HIS50D, ILE194E, ILE5E, ILE74E, ILE76E, ILE81E, LEU214D, LEU215D, LEU216D, LEU218D, LEU230D, LEU235D, LEU38E, LEU69E, LEU87D, LYS207D, LYS223D, LYS226D, LYS231D, LYS234D, LYS241D, LYS33E, LYS62D, LYS6E, LYS73E, LYS77E, LYS86D, MET192E, MET204D, MET208D, MET211D, MET212D, MET222D, MET71E, MET87E, PHE10E, PHE35E, PHE81D, PHE89E, PRO217D, PRO74D, PRO84D, PRO8E, SER1E, SER228D, SER232D, SER36E, SER65E, SER72E, SER88D, THR3E, THR40E, THR42E, THR43E, THR44E, TYR13E, TYR220D, TYR37E, TYR49E, TYR90D, VAL219D, VAL229D, VAL39E, VAL45E, VAL47E, VAL54E, VAL68E, VAL7E
• D-F: ALA236D, ALA65F, ARG224D, ARG233D, ARG238D, ARG58F, ARG61F, ARG64F, ARG71F, ASN53F, ASP56F, ASP57F, ASP67F, GLN72F, GLU52F, ILE62F, LEU230D, LEU235D, LEU54F, LEU66F, LEU68F, LYS223D, LYS231D, LYS234D, LYS63F, MET70F, PHE60F, PRO239D, PRO240D, SER228D, SER232D, SER69F, TRP227D, TYR237D, TYR55F, VAL229D, VAL59F
• D-G: ALA221D, ALA236D, ALA25G, ARG11G, ARG224D, ARG233D, ARG238D, ARG24G, ARG71G, ASP2D, GLN23G, GLU22G, GLU4D, GLU67G, GLY33G, HIS12G, HIS225D, HIS28G, HIS6D, ILE14G, LEU18G, LEU216D, LEU218D, LEU230D, LEU235D, LEU3D, LYS223D, LYS226D, LYS231D, LYS234D, LYS32G, LYS68G, LYS70G, LYS72G, MET222D, PHE21G, PHE26G, PHE30G, PHE66G, PRO20G, PRO217D, PRO239D, PRO240D, PRO27G, SER17G, SER19G, SER228D, SER232D, SER69G, THR15G, TRP227D, TYR16G, TYR220D, TYR237D, TYR29G, VAL10G, VAL13G, VAL219D, VAL229D
• D-H: ALA177D, ALA183D, ALA64H, ALA70H, ARG21H, ARG28D, ARG65H, ASN150D, ASN166D, ASN75H, ASP125D, ASP15H, ASP173D, ASP185D, ASP22D, ASP2D, ASP41H, ASP53H, ASP60H, ASP66H, CYS135D, CYS187D, CYS40H, CYS54H, CYS68H, GLN156D, GLN181D, GLU124D, GLU12H, GLU136D, GLU167D, GLU42H, GLU4D, GLU51H, GLU52H, GLU56H, GLU57H, GLY133D, GLY140D, GLY155D, GLY174D, HIS14D, HIS63H, HIS67H, HIS6D, HIS71H, ILE164D, LEU131D, LEU13H, LEU17H, LEU37H, LEU3D, LEU58H, LEU59H, LEU5D, LEU62H, LEU73H, LEU77H, LYS184D, LYS72H, LYS78H, MET179D, PHE128D, PHE149D, PHE153D, PHE171D, PHE61H, PHE74H, PRO11D, PRO137D, PRO138D, PRO151D, PRO16H, PRO176D, PRO7D, PRO8D, SER129D, SER13D, SER142D, SER180D, SER1D, SER25D, SER45H, SER76H, SER9D, THR132D, THR139D, THR175D, THR178D, THR188D, THR18H, THR24D, THR50H, THR55H, TRP12D, TYR10D, TYR134D, TYR152D, TYR165D, VAL141D, VAL14H, VAL168D, VAL182D, VAL20H, VAL44H, VAL69H
• D-I: GLU39I, LYS241D
• D-J: ALA39J, ALA41J, ARG15D, ARG201D, ARG203D, ARG27D, ARG28D, ASN47J, ASN61J, ASP172D, ASP173D, ASP199D, ASP22D, ASP36J, ASP40J, ASP59D, CYS55D, GLN37J, GLU197D, GLU32J, GLU44J, GLU48J, GLU58D, GLU60D, GLU60J, GLY16D, GLY205D, GLY213D, GLY38J, GLY49J, GLY53D, HIS14D, HIS198D, HIS200D, HIS23D, HIS54J, ILE26D, ILE42J, ILE46J, ILE55J, LEU17D, LEU18D, LEU206D, LEU209D, LEU210D, LEU214D, LEU215D, LEU21D, LEU51D, LEU51J, LYS202D, LYS207D, LYS50J, LYS53J, LYS56J, LYS58J, MET204D, MET208D, MET211D, MET212D, MET222D, PHE20J, PHE31J, PHE35J, SER13D, SER19D, SER20D, SER25D, THR188D, THR24D, THR57D, TRP12D, TRP52J, TYR43J, TYR56D, TYR59J, VAL52D, VAL54D
• E-F: ARG71F, GLN73F, PHE10E, TYR13E
• E-G: ALA25G, ALA31E, ARG14E, ARG15E, ARG24G, ARG32E, ASP12E, ASP4E, ASP9E, GLN23G, GLU17E, GLU22G, GLY34E, HIS28G, HIS2E, ILE14G, ILE5E, LEU18G, LEU19E, LEU38E, LYS32G, LYS33E, LYS6E, PHE10E, PHE21G, PHE26G, PHE35E, PRO16E, PRO20G, PRO27G, PRO8E, SER11E, SER17G, SER19G, SER25E, SER28E, SER29E, SER36E, THR15G, THR40E, TYR13E, TYR16G, TYR37E, VAL18E, VAL39E, VAL7E
• E-J: ALA21J, ALA28J, ALA31E, ALA34J, ALA39J, ALA41E, ALA48E, ALA50E, ALA7J, ARG15J, ARG32E, ARG33J, ARG8J, ASN53E, ASP36J, ASP40J, GLN37J, GLU17E, GLU27E, GLU30E, GLU32J, GLY27J, GLY34E, GLY38J, GLY46E, ILE24J, LEU12J, LEU13J, LEU29J, LEU38E, LEU5J, LEU9J, LYS33E, LYS52E, PHE14J, PHE20J, PHE30J, PHE31J, PHE35E, PHE35J, PRO3J, SER11J, SER28E, SER29E, SER36E, SER56E, THR23J, THR40E, THR42E, THR43E, THR44E, THR4J, THR6J, TYR10J, TYR37E, TYR49E, VAL25J, VAL26J, VAL39E, VAL45E, VAL47E
• E-K: ALA35K, ALA48E, ALA50E, ALA51E, ASN53E, ASP37K, GLY31K, GLY46E, LEU32K, LEU42K, LYS52E, SER38K, SER56E, THR36K, THR44E, TRP34K, TYR49E, VAL33K, VAL45E, VAL47E, VAL55E, VAL59E
• F-G: ALA23F, ALA24F, ALA43G, ARG11G, ARG2G, ARG39G, ARG40G, ARG42G, ARG47G, ARG58F, ARG61F, ARG64F, ARG71F, ARG9G, ASN22F, ASN36G, ASN53F, ASP56F, ASP57F, ASP67F, GLN72F, GLN73F, GLU52F, GLY25F, HIS12G, ILE14G, ILE47F, ILE62F, ILE74F, LEU29F, LEU46G, LEU68F, LEU75F, LEU7G, LYS28F, LYS32G, LYS44F, LYS63F, MET70F, PHE60F, PRO35G, SER69F, THR15G, THR8G, TRP19F, TRP80F, TYR16G, TYR20F, TYR55F, VAL10G, VAL13G, VAL37G, VAL59F
• G-H: ALA75G, ARG36H, ARG43H, ARG47H, ARG71G, ASN73G, ASP53H, ASP60H, GLU51H, GLU52H, GLU56H, GLU57H, HIS63H, LEU59H, LYS68G, LYS70G, LYS72G, PRO74G, THR50H
• G-J: PHE21G, TYR10J
• J-K: ALA21J, ALA21K, ALA26K, ALA28J, ALA29K, ALA34J, ALA35K, ARG16J, ARG33J, ASN16K, ASN49K, ASP37K, GLN22K, GLN37J, GLU32J, GLY25K, GLY27J, GLY28K, GLY31K, GLY38J, GLY50K, ILE24J, ILE41K, ILE48K, LEU13J, LEU22J, LEU23K, LEU29J, LEU32K, LEU42K, LYS51K, PHE20J, PHE30J, PHE31J, PHE52K, PRO19K, PRO46K, SER18J, SER38K, THR17J, THR19J, THR20K, THR23J, TRP17K, TRP24K, TRP34K, TYR47K, VAL18K, VAL25J, VAL26J, VAL27K, VAL30K, VAL33K, VAL45K