1SG1

crystal structure of the receptor-ligand complex between nerve growth factor and the common neurotrophin receptor p75

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 119
  • Norm. En. per Res.: -3.3523
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-90.0525	6.7751	-315.649	-398.9264	119	25	16	14239	0	23	22
A-X	-7.5664	-39.2492	-112.769	-159.5846	73	5	3	5594	6	29	13
B-X	-14.2769	-7.3994	-148.875	-170.5513	67	10	2	5654	1	16	13

Interface residues

• A-B: ALA107A, ALA107B, ALA98A, ARG103A, ARG114A, ARG114B, ARG69A, ARG69B, ARG9B, ASN43A, ASN43B, ASN45A, ASN45B, ASN46A, ASN46B, ASN77A, ASN77B, ASP105A, ASP105B, ASP72A, ASP72B, CYS108A, CYS108B, CYS110A, CYS110B, CYS15A, CYS15B, CYS68A, CYS68B, GLN51A, GLN51B, GLU11A, GLU11B, GLU55A, GLU55B, GLY10B, GLY70A, GLY70B, HIS75A, HIS75B, HIS84A, HIS84B, ILE102A, ILE102B, ILE104A, ILE104B, ILE31A, ILE31B, ILE44A, ILE44B, ILE71A, ILE71B, LEU112A, LEU112B, LEU90A, LEU90B, LYS50A, LYS50B, LYS74A, LYS74B, LYS88A, LYS88B, PHE101A, PHE101B, PHE12A, PHE12B, PHE49A, PHE49B, PHE53A, PHE53B, PHE54A, PHE54B, PHE86A, PHE86B, SER113A, SER113B, SER13A, SER13B, SER17A, SER17B, SER19A, SER19B, SER47A, SER47B, SER73A, SER73B, SER78A, SER78B, THR106A, THR106B, THR56A, THR56B, THR81A, THR81B, THR83A, THR83B, THR85A, THR85B, TRP21A, TRP21B, TRP76A, TRP76B, TRP99A, TRP99B, TYR52A, TYR52B, TYR79A, TYR79B, VAL109A, VAL109B, VAL111A, VAL111B, VAL14A, VAL14B, VAL42A, VAL42B, VAL48B, VAL87A, VAL87B
• A-X: ALA69X, ALA74X, ALA77X, ALA89A, ALA97A, ALA98A, ARG100A, ARG103A, ARG114A, ARG80X, ASN20X, ASN42X, ASP134X, ASP30A, ASP41X, ASP47X, ASP72A, ASP75X, ASP76X, ASP93A, CYS121X, CYS136X, CYS139X, CYS19X, CYS71X, CYS79X, GLN96A, GLU119X, GLU120X, GLU123X, GLU23X, GLU73X, GLY105X, GLY124X, GLY22X, GLY94A, HIS75A, ILE31A, LEU106X, LEU112A, LEU137X, LEU21X, LYS115A, LYS32A, LYS34A, LYS74A, LYS88A, LYS95A, MET67X, MET92A, PHE101A, PHE45X, PHE86A, PRO122X, PRO135X, PRO138X, PRO70X, SER127X, SER46X, SER5X, SER68X, THR125X, THR140X, THR91A, TRP76A, TRP99A, TYR126X, VAL107X, VAL141X, VAL48X, VAL49X, VAL72X, VAL78X
• B-X: ALA69X, ALA77X, ALA82X, ARG59B, ARG69B, ARG80X, ARG9B, ASN131X, ASN42X, ASN46B, ASP134X, ASP16B, ASP41X, CYS118X, CYS136X, CYS39X, CYS71X, CYS79X, GLN111X, GLN51B, GLU119X, GLU11B, GLU143X, GLU41B, GLU73X, GLY105X, GLY10B, GLY23B, GLY70B, HIS132X, LEU106X, LEU137X, LEU40X, LYS50B, LYS74B, MET67X, PHE108X, PHE12B, PHE49B, PHE53B, PHE54B, PRO135X, PRO138X, PRO38X, PRO70X, SER109X, SER13B, SER17B, SER19B, SER47B, SER66X, SER68X, TRP21B, TYR52B, TYR83X, VAL107X, VAL117X, VAL133X, VAL14B, VAL18B, VAL20B, VAL22B, VAL42B, VAL43X, VAL48B, VAL72X, VAL78X