1SA1

tubulin-podophyllotoxin: stathmin-like domain complex

• Total interactions analyzed: 10
• Total true interactions: 7
• Strongest Interaction:
  • Chains: A-E
  • Int. Res.: 157
  • Norm. En. per Res.: -2.9351
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-17.9422	-12.6121	-265.915	-296.4693	127	27	4	12043	4	46	42
A-E	-52.3547	-59.4571	-349.004	-460.8158	157	45	11	15237	3	51	52
B-C	-20.1646	-58.1898	-210.423	-288.7774	120	27	1	9330	3	28	31
B-E	-3.6371	-39.8432	-74.0328	-117.5131	67	6	3	4094	3	49	49
C-D	-9.7369	-3.709	-253.579	-267.0249	120	18	4	11416	5	48	43
C-E	-9.7198	-36.4985	-107.474	-153.6923	74	11	1	5259	2	38	34
D-E	-7.1167	-24.8813	-64.4996	-96.4976	65	3	2	4188	3	54	45

Interface residues

• A-B: ALA100A, ALA104A, ALA174A, ALA180A, ALA250B, ALA256B, ALA316B, ALA400A, ALA403A, ALA438B, ALA99A, ARG105A, ARG164B, ARG214A, ARG221A, ARG253B, ARG264B, ARG2B, ARG311B, ARG390A, ARG402A, ASN101A, ASN102A, ASN186A, ASN249B, ASN258B, ASN349B, ASN350B, ASN380B, ASP130B, ASP163B, ASP199B, ASP251B, ASP329B, ASP396A, ASP437B, ASP98A, CYS129B, CYS131B, GLN11A, GLN133B, GLN15A, GLN176A, GLN247B, GLN434B, GLU183A, GLU200B, GLU220A, GLU327B, GLU330B, GLU345B, GLU411A, GLU47B, GLU71A, GLU77A, GLU97A, GLY143A, GLY144A, GLY246B, HIS266B, HIS393A, HIS406A, ILE110A, ILE165B, ILE347B, LEU132B, LEU248B, LEU252B, LEU255B, LEU265B, LEU313B, LEU333B, LEU391A, LEU397A, LYS254B, LYS326B, LYS352B, LYS394A, LYS401A, LYS96A, MET166B, MET259B, MET323B, MET325B, MET398A, PHE262B, PHE268B, PHE395A, PHE404A, PRO173A, PRO175A, PRO184A, PRO222A, PRO245B, PRO261B, PRO263B, PRO348B, PRO72A, SER178A, SER324B, THR109A, THR145A, THR179A, THR223A, THR225A, THR314B, THR353B, THR73A, TRP346B, TRP407A, TYR185A, TYR210A, TYR224A, TYR399A, TYR408A, TYR435B, VAL177A, VAL181A, VAL182A, VAL257B, VAL260B, VAL315B, VAL344B, VAL351B, VAL355B, VAL405A, VAL74A
• A-E: ALA104A, ALA240A, ALA247A, ALA330A, ALA331A, ALA333A, ALA37E, ALA427A, ALA56E, ALA57E, ARG105A, ARG156A, ARG243A, ARG264A, ARG339A, ARG41E, ARG42E, ARG60E, ARG61E, ASN12E, ASN249A, ASN258A, ASN329A, ASN356A, ASN36E, ASP116A, ASP160A, ASP245A, ASP30E, ASP327A, ASP345A, ASP424A, ASP431A, ASP438A, CYS14E, CYS315A, CYS347A, GLN18E, GLN51E, GLN64E, GLU10E, GLU113A, GLU155A, GLU196A, GLU21E, GLU254A, GLU34E, GLU358A, GLU411A, GLU414A, GLU415A, GLU417A, GLU434A, GLU48E, GLU49E, GLU55E, GLU58E, GLU59E, GLU65E, GLU7E, GLY106A, GLY111A, GLY162A, GLY17E, GLY246A, GLY31E, GLY350A, GLY354A, GLY410A, GLY412A, GLY416A, GLY436A, GLY45A, HIS107A, HIS197A, HIS266A, HIS406A, ILE110A, ILE115A, ILE23E, ILE332A, ILE335A, ILE341A, ILE355A, ILE50E, ILE9E, LEU11E, LEU152A, LEU195A, LEU248A, LEU24E, LEU317A, LEU428A, LEU47E, LEU54E, LYS112A, LYS13E, LYS25E, LYS326A, LYS336A, LYS352A, LYS430A, LYS53E, LYS62E, MET313A, MET413A, MET6E, PHE20E, PHE244A, PHE29E, PHE343A, PHE351A, PHE35E, PRO261A, PRO263A, PRO26E, PRO27E, PRO325A, PRO33E, PRO348A, PRO45E, SER158A, SER16E, SER19E, SER241A, SER28E, SER38E, SER439A, SER46E, SER48A, THR109A, THR15E, THR257A, THR334A, THR337A, THR349A, TRP346A, TRP407A, TYR108A, TYR262A, TYR319A, TYR357A, TYR408A, TYR432A, TYR63E, VAL159A, VAL22E, VAL250A, VAL323A, VAL324A, VAL328A, VAL32E, VAL344A, VAL353A, VAL409A, VAL435A, VAL8E
• B-C: ALA247C, ALA314C, ALA397B, ALA403B, ALA99B, ARG264C, ARG2C, ARG400B, ARG401B, ASN101B, ASN102B, ASN186B, ASN249C, ASN258C, ASN329C, ASN380C, ASP179B, ASP199C, ASP251C, ASP327C, ASP345C, ASP431C, ASP438C, ASP69B, ASP76B, CYS200C, CYS315C, CYS316C, CYS347C, GLN11B, GLN133C, GLN256C, GLN394B, GLN96B, GLU110B, GLU183B, GLU254C, GLU393B, GLU411B, GLU433C, GLU434C, GLU71B, GLY100B, GLY131C, GLY143B, GLY144B, GLY350C, GLY436C, GLY73B, GLY98B, HIS266C, HIS406B, ILE265C, ILE355C, ILE391B, LEU248C, LEU252C, LEU259C, LEU405B, LYS105B, LYS163C, LYS164C, LYS176B, LYS326C, LYS352C, LYS402B, LYS430C, MET313C, MET398B, MET75B, PHE214B, PHE255C, PHE343C, PHE351C, PHE395B, PHE399B, PHE404B, PRO175B, PRO184B, PRO222B, PRO261C, PRO263C, PRO325C, PRO348C, PRO72B, SER165C, SER178B, SER439C, SER77B, SER97B, THR109B, THR130C, THR180B, THR220B, THR221B, THR223B, THR253C, THR257C, THR349C, THR396B, THR409B, THR74B, TRP346C, TRP407B, TYR185B, TYR210B, TYR262C, TYR408B, TYR432C, VAL177B, VAL181B, VAL182B, VAL250C, VAL260C, VAL323C, VAL324C, VAL344C, VAL353C, VAL435C, VAL437C
• B-E: ALA104B, ALA112B, ALA66E, ALA73E, ALA86E, ARG158B, ARG253B, ARG61E, ARG76E, ARG80E, ASN197B, ASN90E, ASP163B, ASP414B, GLN193B, GLN64E, GLN84E, GLU110B, GLU113B, GLU159B, GLU160B, GLU196B, GLU411B, GLU417B, GLU420B, GLU65E, GLU74E, GLU77E, GLU79E, GLU81E, GLU88E, GLU89E, GLY111B, GLY410B, GLY412B, HIS107B, HIS192B, HIS71E, HIS78E, ILE154B, ILE157B, ILE83E, ILE87E, LEU152B, LEU189B, LEU194B, LEU68E, LEU69E, LEU72E, LYS156B, LYS70E, LYS75E, LYS85E, MET413B, MET416B, PRO162B, PRO263B, SER155B, THR109B, THR151B, THR409B, TRP103B, TYR108B, TYR161B, TYR408B, VAL115B, VAL82E
• C-D: ALA100C, ALA104C, ALA174C, ALA180C, ALA250D, ALA256D, ALA400C, ALA403C, ALA99C, ARG105C, ARG164D, ARG214C, ARG221C, ARG253D, ARG264D, ARG2D, ARG311D, ARG402C, ASN101C, ASN102C, ASN186C, ASN249D, ASN258D, ASN349D, ASN350D, ASN380D, ASP130D, ASP163D, ASP199D, ASP251D, ASP329D, ASP437D, ASP98C, CYS129D, CYS131D, GLN11C, GLN133D, GLN15C, GLN176C, GLN247D, GLU183C, GLU200D, GLU220C, GLU327D, GLU330D, GLU345D, GLU3D, GLU411C, GLU47D, GLU71C, GLU77C, GLU97C, GLY143C, GLY246D, GLY95C, HIS266D, HIS393C, HIS406C, ILE110C, ILE165D, ILE347D, LEU132D, LEU248D, LEU252D, LEU255D, LEU265D, LEU313D, LEU333D, LEU391C, LEU397C, LEU70C, LYS254D, LYS326D, LYS352D, LYS394C, LYS401C, LYS96C, MET166D, MET259D, MET323D, MET325D, MET398C, PHE262D, PHE268D, PHE395C, PHE404C, PRO173C, PRO175C, PRO184C, PRO245D, PRO261D, PRO263D, PRO348D, PRO72C, SER178C, SER324D, THR109C, THR179C, THR223C, THR225C, THR314D, THR353D, THR73C, TRP346D, TRP407C, TYR185C, TYR210C, TYR224C, TYR399C, TYR408C, TYR435D, VAL177C, VAL181C, VAL182C, VAL257D, VAL260D, VAL315D, VAL344D, VAL351D, VAL405C
• C-E: ALA102E, ALA104C, ALA114E, ALA421C, ALA86E, ALA97E, ARG105C, ARG112E, ARG156C, ASN108E, ASN111E, ASN90E, ASN91E, ASP116C, ASP160C, GLU106E, GLU110E, GLU113C, GLU113E, GLU155C, GLU196C, GLU411C, GLU414C, GLU415C, GLU417C, GLU420C, GLU99E, GLY111C, GLY162C, GLY410C, GLY412C, HIS107C, HIS115E, HIS192C, HIS197C, ILE110C, ILE115C, ILE87E, ILE94E, LEU101E, LEU116E, LEU119C, LEU152C, LEU153C, LEU157C, LEU189C, LYS100E, LYS104E, LYS109E, LYS112C, LYS163C, LYS164C, LYS166C, LYS95E, LYS98E, MET105E, MET119E, MET154C, MET413C, MET96E, PHE93E, SER107E, SER151C, SER158C, THR109C, THR190C, THR193C, THR194C, TYR103C, TYR108C, TYR161C, TYR408C, VAL159C, VAL409C
• D-E: ALA112D, ALA117E, ALA130E, ARG112E, ARG122E, ARG134E, ARG158D, ARG164D, ARG253D, ASN136E, ASN197D, ASP127E, ASP163D, ASP199D, ASP414D, GLN124E, GLN193D, GLU110D, GLU113D, GLU121E, GLU131E, GLU132E, GLU138E, GLU141E, GLU159D, GLU160D, GLU196D, GLU411D, GLU415D, GLU417D, GLU420D, GLY111D, GLY410D, GLY412D, HIS107D, HIS129E, HIS192D, HIS406D, ILE154D, ILE165D, LEU116E, LEU120E, LEU123E, LEU139E, LEU152D, LYS126E, LYS128E, LYS135E, LYS137E, LYS140E, LYS156D, MET119E, MET413D, MET416D, PRO162D, SER155D, THR109D, THR151D, THR409D, TRP103D, TYR108D, TYR161D, TYR408D, VAL115D, VAL133E