1S5E

cholera holotoxin, crystal form 1

• Total interactions analyzed: 66
• Total true interactions: 32
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 107
  • Norm. En. per Res.: -5.2533
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	-6.9288	4.0042	-37.4552	-40.3798	38	1	2	2045	1	19	17
A-E	-11.1229	-35.0468	-98.6261	-144.7958	47	6	1	4312	3	27	26
A-F	-21.6569	-31.5657	-119.502	-172.7246	53	3	0	4927	1	23	23
A-G	-54.4018	-8.7681	-121.669	-184.8389	52	4	0	4672	2	29	29
A-H	-5.5068	-9.8383	-58.0209	-73.366	46	4	1	2658	1	24	24
D-E	-94.8692	-65.7405	-331.397	-492.0068	106	15	11	13577	3	40	43
D-F	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	1
D-G	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	2	1
D-H	-100.4787	-74.5468	-349.658	-524.6835	107	12	10	13837	5	40	43
D-B	-6.3962	0.0	-8.8077	-15.2039	12	1	0	442	0	2	0
E-F	-103.2985	-82.9116	-375.897	-562.1071	107	15	10	14441	5	39	42
E-G	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	1
E-H	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	1
E-B	0.0	0.0	-17.5028	-17.5028	29	1	0	1199	0	7	11
F-G	-78.2774	-81.643	-363.669	-523.5894	107	11	10	14090	5	40	43
F-H	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	1
G-H	-76.3094	-75.7909	-349.466	-501.5663	104	18	11	13658	5	39	43
B-J	-13.7885	-3.3449	-33.7805	-50.914	42	2	2	1927	2	21	19
B-K	-7.9321	-2.0794	-87.5922	-97.6037	49	10	1	4028	1	28	28
B-L	-22.1113	-25.209	-114.006	-161.3263	50	3	0	4762	2	22	23
B-M	-51.297	-6.8358	-126.72	-184.8528	51	7	0	4710	2	27	29
B-N	0.0	-11.4741	-75.7004	-87.1745	46	5	1	3123	1	24	26
J-K	-101.1743	-72.8996	-352.378	-526.4519	109	11	10	13854	4	41	43
J-L	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	1
J-M	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	1
J-N	-95.3154	-70.7229	-345.962	-512.0004	107	11	11	13543	5	40	43
K-L	-102.3496	-69.997	-366.973	-539.3196	109	14	10	13890	3	39	42
K-M	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	1	1
K-N	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	1
L-M	-83.1716	-82.574	-349.95	-515.6956	106	14	11	13557	5	40	44
L-N	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	1
M-N	-75.8255	-73.7342	-355.63	-505.1897	106	19	11	13881	4	40	42

Interface residues

• A-D: ALA80D, ARG235A, ARG33A, ARG67D, ARG73D, ASN103D, ASP229A, ASP231A, ASP32A, ASP70D, GLN18A, GLN227A, GLU29A, GLU66D, GLU79D, GLY20A, GLY225A, GLY34A, ILE222A, ILE230A, ILE236A, ILE74D, LEU77D, LYS17A, LYS219A, LYS23D, LYS63D, LYS81D, PHE223A, PHE31A, SER19A, SER224A, SER228A, THR232A, THR71D, THR78D, TYR226A, TYR30A
• A-E: ALA102E, ALA64E, ALA75E, ALA80E, ARG220A, ARG235A, ARG67E, ARG73E, ASN103E, ASN234A, ASP212A, ASP231A, ASP70E, GLN215A, GLN221A, GLN227A, GLU213A, GLU66E, GLU79E, GLY225A, HIS233A, ILE222A, ILE230A, ILE236A, ILE74E, LEU77E, LYS217A, LYS219A, LYS23E, LYS62E, LYS63E, LYS69E, LYS81E, MET101E, MET68E, PHE223A, PHE31A, SER216A, SER224A, SER228A, THR232A, THR71E, THR78E, TYR214A, TYR226A, TYR76E, VAL218A
• A-F: ALA102F, ALA64F, ALA75F, ALA80F, ARG146A, ARG148A, ARG220A, ARG235A, ARG67F, ARG73F, ASN103F, ASN152A, ASN234A, ASP229A, ASP231A, ASP59F, ASP70F, GLN221A, GLN227A, GLU66F, GLU79F, GLY225A, HIS233A, ILE222A, ILE230A, ILE236A, ILE24F, ILE65F, ILE74F, LEU153A, LEU77F, LYS217A, LYS219A, LYS23F, LYS62F, LYS63F, LYS69F, LYS81F, MET101F, MET68F, PHE223A, PHE25F, SER151A, SER224A, SER228A, SER26F, THR232A, THR71F, THR78F, TYR149A, TYR226A, TYR27F, TYR76F
• A-G: ALA102G, ALA64G, ALA75G, ALA80G, ARG141A, ARG143A, ARG146A, ARG148A, ARG235A, ARG67G, ARG73G, ASN142A, ASN234A, ASP147A, ASP229A, ASP231A, ASP70G, GLN221A, GLN227A, GLU66G, GLU79G, GLY144A, GLY225A, HIS233A, ILE222A, ILE230A, ILE24G, ILE74G, LEU72G, LEU77G, LYS23G, LYS62G, LYS63G, LYS69G, LYS81G, MET101G, PHE223A, PHE25G, SER151A, SER224A, SER228A, SER26G, THR232A, THR71G, THR78G, TYR125A, TYR145A, TYR149A, TYR150A, TYR226A, TYR27G, TYR76G
• A-H: ALA75H, ALA80H, ARG141A, ARG143A, ARG146A, ARG235A, ARG67H, ARG73H, ASN103H, ASN142A, ASN234A, ASP14A, ASP229A, ASP22H, ASP231A, ASP70H, GLN18A, GLN227A, GLU29A, GLU66H, GLU79H, GLY144A, GLY225A, ILE222A, ILE230A, ILE24H, ILE74H, LEU77H, LYS17A, LYS23H, LYS43H, LYS63H, LYS81H, PHE223A, PHE25H, PRO13A, SER228A, SER26H, THR71H, THR78H, TRP127A, TYR121A, TYR145A, TYR226A, TYR27H, TYR76H
• D-E: ALA102D, ALA10D, ALA32E, ALA38E, ALA64D, ALA64E, ALA75D, ALA80D, ALA95D, ALA95E, ALA97D, ALA98D, ARG35E, ARG67D, ARG67E, ARG73D, ARG73E, ASN103D, ASN4D, ASP59D, ASP70D, ASP70E, ASP7D, CYS86D, CYS9D, GLN3D, GLN49D, GLN49E, GLN56D, GLN61D, GLU11D, GLU29E, GLU36E, GLU51D, GLU51E, GLU66D, GLU66E, GLU79D, GLU79E, GLU83D, GLY33E, GLY45E, HIS57D, ILE24E, ILE39E, ILE40E, ILE58D, ILE5D, ILE65D, ILE65E, ILE74D, ILE74E, ILE96D, ILE99D, LEU31E, LEU72D, LEU72E, LEU77D, LEU77E, LEU85D, LEU8D, LYS23E, LYS34E, LYS62D, LYS62E, LYS63D, LYS63E, LYS69D, LYS69E, LYS81D, LYS84D, LYS91E, MET101D, MET37E, MET68D, MET68E, PHE25E, PHE48E, PRO2D, PRO53E, PRO93E, SER100D, SER26E, SER30E, SER60D, THR15D, THR1D, THR28E, THR41E, THR47E, THR6D, THR71D, THR71E, THR78D, THR78E, THR92E, TRP88D, TYR12D, TYR27E, TYR76D, TYR76E, VAL50D, VAL50E, VAL52E, VAL82D, VAL87D
• D-F: ARG67D, ARG73F
• D-G: ARG67G, ARG73D
• D-H: ALA102H, ALA32D, ALA38D, ALA46D, ALA64D, ALA64H, ALA75H, ALA80H, ALA95D, ALA95H, ALA97H, ALA98H, ARG35D, ARG67D, ARG67H, ARG73D, ARG73H, ASN103H, ASN4H, ASP59H, ASP70D, ASP70H, ASP7H, CYS86H, CYS9H, GLN3H, GLN49D, GLN49H, GLN56H, GLN61H, GLU11H, GLU29D, GLU36D, GLU51D, GLU51H, GLU66D, GLU66H, GLU79D, GLU79H, GLU83H, GLY33D, GLY45D, HIS57H, HIS94D, ILE24D, ILE39D, ILE40D, ILE58H, ILE5H, ILE65D, ILE65H, ILE74D, ILE74H, ILE96H, ILE99H, LEU31D, LEU72D, LEU72H, LEU77D, LEU77H, LEU85H, LEU8H, LYS23D, LYS34D, LYS62D, LYS62H, LYS63D, LYS63H, LYS69D, LYS69H, LYS81H, LYS84H, LYS91D, MET101H, MET37D, MET68D, MET68H, PHE25D, PHE48D, PRO2H, PRO53D, PRO93D, SER100H, SER26D, SER30D, SER60H, THR15H, THR1H, THR28D, THR41D, THR47D, THR6H, THR71D, THR71H, THR78D, THR78H, THR92D, TRP88H, TYR12H, TYR27D, TYR76D, TYR76H, VAL50D, VAL50H, VAL52D, VAL82H, VAL87H
• D-B: GLN74B, GLU11D, GLY133B, GLY79B, HIS131B, HIS70B, PHE132B, PRO2D, SER81B, THR1D, VAL130B, VAL134B
• E-F: ALA102E, ALA32F, ALA38F, ALA46F, ALA64E, ALA64F, ALA75E, ALA80E, ALA95E, ALA95F, ALA97E, ALA98E, ARG35F, ARG67E, ARG67F, ARG73E, ARG73F, ASN103E, ASN4E, ASP59E, ASP70E, ASP70F, ASP7E, CYS86E, CYS9E, GLN3E, GLN49E, GLN49F, GLN56E, GLN56F, GLN61E, GLU11E, GLU29F, GLU36F, GLU51E, GLU51F, GLU66E, GLU66F, GLU79E, GLU79F, GLU83E, GLY33F, GLY45F, HIS57E, HIS94F, ILE24F, ILE39F, ILE40F, ILE58E, ILE5E, ILE65E, ILE65F, ILE74E, ILE74F, ILE96E, ILE99E, LEU31F, LEU72E, LEU72F, LEU77F, LEU85E, LEU8E, LYS23F, LYS34F, LYS43F, LYS62E, LYS62F, LYS63E, LYS63F, LYS69E, LYS69F, LYS81E, LYS84E, LYS91F, MET101E, MET37F, MET68E, MET68F, PHE25F, PHE48F, PRO2E, PRO53F, PRO93F, SER100E, SER26F, SER30F, SER60E, THR15E, THR1E, THR28F, THR41F, THR47F, THR6E, THR71E, THR71F, THR78E, THR78F, THR92F, TRP88E, TYR12E, TYR27F, TYR76F, VAL50E, VAL50F, VAL52F, VAL82E, VAL87E
• E-G: ARG67E, ARG73G
• E-H: ARG67H, ARG73E
• E-B: ARG35E, ARG67B, ASN14E, ASN89E, ASN90E, ASP136B, GLN16E, GLN49E, GLN56E, GLN74B, GLU137B, GLU51E, GLY133B, HIS131B, HIS70B, HIS94E, LEU135B, LEU66B, LEU71B, LYS34E, LYS91E, PHE132B, PRO93E, SER55E, SER81B, THR75B, THR92E, VAL134B, VAL52E
• F-G: ALA102F, ALA32G, ALA38G, ALA46G, ALA64F, ALA64G, ALA75F, ALA80F, ALA95F, ALA95G, ALA97F, ALA98F, ARG35G, ARG67F, ARG67G, ARG73F, ARG73G, ASN103F, ASN4F, ASP59F, ASP70F, ASP70G, ASP7F, CYS86F, CYS9F, GLN3F, GLN49F, GLN49G, GLN56F, GLN56G, GLN61F, GLU11F, GLU29G, GLU36G, GLU51F, GLU51G, GLU66F, GLU66G, GLU79F, GLU83F, GLY33G, GLY45G, HIS57F, HIS94G, ILE24G, ILE39G, ILE40G, ILE58F, ILE5F, ILE65F, ILE65G, ILE74F, ILE74G, ILE96F, ILE99F, LEU31G, LEU72F, LEU72G, LEU77F, LEU77G, LEU85F, LEU8F, LYS34G, LYS62F, LYS62G, LYS63F, LYS63G, LYS69F, LYS69G, LYS81F, LYS84F, LYS91G, MET101F, MET37G, MET68F, MET68G, PHE25G, PHE48G, PRO2F, PRO53F, PRO53G, PRO93G, SER100F, SER26G, SER30G, SER60F, THR15F, THR1F, THR28G, THR41G, THR47G, THR6F, THR71F, THR71G, THR78F, THR78G, THR92G, TRP88F, TYR12F, TYR27G, TYR76F, TYR76G, VAL50F, VAL50G, VAL52G, VAL82F, VAL87F
• F-H: ARG67F, ARG73H
• G-H: ALA102G, ALA32H, ALA38H, ALA46H, ALA64G, ALA64H, ALA75G, ALA80G, ALA95G, ALA95H, ALA97G, ALA98G, ARG35H, ARG67G, ARG67H, ARG73G, ARG73H, ASN4G, ASP59G, ASP70G, ASP70H, ASP7G, CYS86G, CYS9G, GLN3G, GLN49G, GLN49H, GLN56G, GLN61G, GLU11G, GLU29H, GLU36H, GLU51G, GLU51H, GLU66G, GLU66H, GLU79G, GLU83G, GLY33H, GLY45H, HIS57G, HIS94H, ILE24H, ILE39H, ILE40H, ILE58G, ILE5G, ILE65G, ILE65H, ILE74G, ILE74H, ILE96G, ILE99G, LEU31H, LEU72G, LEU72H, LEU77H, LEU85G, LEU8G, LYS23H, LYS34H, LYS62G, LYS62H, LYS63G, LYS63H, LYS69G, LYS69H, LYS81G, LYS84G, LYS91H, MET101G, MET37H, MET68G, MET68H, PHE25H, PHE48H, PRO2G, PRO53H, PRO93H, SER100G, SER26H, SER30H, SER60G, THR15G, THR1G, THR28H, THR41H, THR47H, THR6G, THR71G, THR71H, THR78G, THR78H, THR92H, TRP88G, TYR12G, TYR27H, TYR76G, TYR76H, VAL50G, VAL50H, VAL52H, VAL82G, VAL87G
• B-J: ALA75J, ALA80J, ARG235B, ARG33B, ARG67J, ARG73J, ASN103J, ASN234B, ASP229B, ASP231B, ASP32B, ASP70J, GLN18B, GLN215B, GLN227B, GLU29B, GLU66J, GLU79J, GLY20B, GLY225B, ILE222B, ILE230B, ILE74J, LEU77J, LYS17B, LYS219B, LYS23J, LYS63J, LYS81J, MET101J, PHE223B, PHE31B, SER19B, SER224B, SER228B, SER28B, THR232B, THR71J, THR78J, TYR226B, TYR30B, TYR76J
• B-K: ALA102K, ALA64K, ALA75K, ALA80K, ARG220B, ARG235B, ARG33B, ARG67K, ARG73K, ASN103K, ASN234B, ASP212B, ASP229B, ASP231B, ASP70K, GLN215B, GLN221B, GLN227B, GLU213B, GLU66K, GLU79K, GLY225B, HIS233B, ILE222B, ILE230B, ILE74K, LEU72K, LEU77K, LYS209B, LYS217B, LYS219B, LYS23K, LYS43K, LYS63K, LYS81K, MET101K, MET68K, PHE223B, PHE31B, SER216B, SER224B, SER228B, THR232B, THR71K, THR78K, TYR214B, TYR226B, TYR76K, VAL218B
• B-L: ALA102L, ALA64L, ALA75L, ALA80L, ARG146B, ARG148B, ARG220B, ARG67L, ARG73L, ASN103L, ASN152B, ASN234B, ASP229B, ASP231B, ASP59L, ASP70L, GLN221B, GLN227B, GLU66L, GLU79L, GLY225B, HIS233B, ILE222B, ILE230B, ILE24L, ILE65L, ILE74L, LEU153B, LEU77L, LYS217B, LYS219B, LYS23L, LYS62L, LYS63L, LYS69L, LYS81L, MET101L, MET68L, PHE223B, PHE25L, SER224B, SER228B, SER26L, THR232B, THR71L, THR78L, TYR149B, TYR226B, TYR27L, TYR76L
• B-M: ALA102M, ALA75M, ALA80M, ARG141B, ARG143B, ARG146B, ARG148B, ARG67M, ARG73M, ASN103M, ASN142B, ASN234B, ASP147B, ASP229B, ASP22M, ASP231B, ASP70M, GLN221B, GLN227B, GLU66M, GLU79M, GLY144B, GLY225B, HIS233B, ILE222B, ILE230B, ILE24M, ILE74M, LEU72M, LEU77M, LYS23M, LYS63M, LYS69M, LYS81M, MET101M, PHE223B, PHE25M, SER151B, SER224B, SER228B, SER26M, THR232B, THR71M, THR78M, TYR125B, TYR145B, TYR149B, TYR150B, TYR226B, TYR27M, TYR76M
• B-N: ALA102N, ALA75N, ALA80N, ARG141B, ARG143B, ARG146B, ARG235B, ARG67N, ARG73N, ASN103N, ASN142B, ASN234B, ASP14B, ASP229B, ASP22N, ASP231B, ASP70N, GLN18B, GLN227B, GLU15B, GLU29B, GLU66N, GLU79N, GLY144B, GLY225B, ILE222B, ILE230B, ILE24N, ILE74N, LEU77N, LYS17B, LYS23N, LYS63N, LYS81N, PHE223B, PHE25N, PRO13B, SER228B, SER26N, THR71N, THR78N, TRP127B, TYR121B, TYR145B, TYR226B, TYR76N
• J-K: ALA102J, ALA32K, ALA38K, ALA46K, ALA64J, ALA64K, ALA75J, ALA80J, ALA95J, ALA95K, ALA97J, ALA98J, ARG35K, ARG67J, ARG67K, ARG73J, ARG73K, ASN103J, ASN14J, ASN4J, ASP59J, ASP70J, ASP70K, ASP7J, CYS86J, CYS9J, GLN3J, GLN49J, GLN49K, GLN56J, GLN61J, GLU11J, GLU29K, GLU36K, GLU51J, GLU51K, GLU66J, GLU66K, GLU79J, GLU79K, GLU83J, GLY33K, GLY45K, HIS57J, HIS94K, ILE24K, ILE39K, ILE40K, ILE58J, ILE5J, ILE65J, ILE65K, ILE74J, ILE74K, ILE96J, ILE99J, LEU31K, LEU72J, LEU72K, LEU77J, LEU77K, LEU85J, LEU8J, LYS23K, LYS34K, LYS62J, LYS62K, LYS63J, LYS63K, LYS69J, LYS69K, LYS81J, LYS84J, LYS91K, MET101J, MET37K, MET68J, MET68K, PHE25K, PHE48K, PRO2J, PRO53J, PRO53K, PRO93K, SER100J, SER26K, SER30K, SER60J, THR15J, THR1J, THR28K, THR41K, THR47K, THR6J, THR71J, THR71K, THR78J, THR78K, THR92K, TRP88J, TYR12J, TYR27K, TYR76J, TYR76K, VAL50J, VAL50K, VAL52K, VAL82J, VAL87J
• J-L: ARG67J, ARG73L
• J-M: ARG67M, ARG73J
• J-N: ALA102N, ALA32J, ALA38J, ALA46J, ALA64J, ALA64N, ALA75N, ALA80N, ALA95J, ALA95N, ALA97N, ALA98N, ARG35J, ARG67J, ARG67N, ARG73J, ARG73N, ASN103N, ASN4N, ASP59N, ASP70J, ASP70N, ASP7N, CYS86N, CYS9N, GLN3N, GLN49J, GLN49N, GLN56N, GLN61N, GLU11N, GLU29J, GLU36J, GLU51J, GLU51N, GLU66J, GLU66N, GLU79J, GLU79N, GLU83N, GLY33J, GLY45J, HIS57N, HIS94J, ILE24J, ILE39J, ILE40J, ILE58N, ILE5N, ILE65J, ILE65N, ILE74J, ILE74N, ILE96N, ILE99N, LEU31J, LEU72J, LEU72N, LEU77J, LEU77N, LEU85N, LEU8N, LYS23J, LYS34J, LYS62J, LYS62N, LYS63J, LYS63N, LYS69J, LYS69N, LYS81N, LYS84N, LYS91J, MET101N, MET37J, MET68J, MET68N, PHE25J, PHE48J, PRO2N, PRO53J, PRO93J, SER100N, SER26J, SER30J, SER60N, THR15N, THR1N, THR28J, THR41J, THR47J, THR6N, THR71J, THR71N, THR78J, THR78N, THR92J, TRP88N, TYR12N, TYR27J, TYR76J, TYR76N, VAL50J, VAL50N, VAL52J, VAL82N, VAL87N
• K-L: ALA102K, ALA32L, ALA38L, ALA46L, ALA64K, ALA64L, ALA75K, ALA80K, ALA95K, ALA95L, ALA97K, ALA98K, ARG35L, ARG67K, ARG67L, ARG73K, ARG73L, ASN103K, ASN4K, ASP59K, ASP70K, ASP70L, ASP7K, CYS86K, CYS9K, GLN3K, GLN49K, GLN49L, GLN56K, GLN56L, GLN61K, GLU11K, GLU29L, GLU36L, GLU51K, GLU51L, GLU66K, GLU66L, GLU79K, GLU79L, GLU83K, GLY33L, GLY45L, HIS57K, HIS94L, ILE24L, ILE39L, ILE40L, ILE58K, ILE5K, ILE65K, ILE65L, ILE74K, ILE74L, ILE96K, ILE99K, LEU31L, LEU72K, LEU72L, LEU77K, LEU77L, LEU85K, LEU8K, LYS23L, LYS34L, LYS43L, LYS62K, LYS62L, LYS63K, LYS63L, LYS69K, LYS69L, LYS81K, LYS84K, LYS91L, MET101K, MET37L, MET68K, MET68L, PHE25L, PHE48L, PRO2K, PRO53L, PRO93L, SER100K, SER26L, SER30L, SER60K, THR15K, THR1K, THR28L, THR41L, THR47L, THR6K, THR71K, THR71L, THR78K, THR78L, THR92L, TRP88K, TYR12K, TYR27L, TYR76K, TYR76L, VAL50K, VAL50L, VAL52L, VAL82K, VAL87K
• K-M: ARG67K, ARG73M
• K-N: ARG67N, ARG73K
• L-M: ALA102L, ALA32M, ALA38M, ALA46M, ALA64L, ALA64M, ALA75L, ALA80L, ALA95L, ALA95M, ALA97L, ALA98L, ARG35M, ARG67L, ARG67M, ARG73L, ARG73M, ASN103L, ASN4L, ASP59L, ASP70L, ASP70M, ASP7L, CYS86L, CYS9L, GLN3L, GLN49L, GLN49M, GLN56L, GLN56M, GLN61L, GLU11L, GLU29M, GLU36M, GLU51L, GLU51M, GLU66L, GLU66M, GLU79L, GLU83L, GLY33M, GLY45M, HIS57L, HIS94M, ILE24M, ILE39M, ILE40M, ILE58L, ILE5L, ILE65L, ILE65M, ILE74L, ILE74M, ILE96L, ILE99L, LEU31M, LEU72L, LEU72M, LEU77L, LEU77M, LEU85L, LEU8L, LYS34M, LYS62L, LYS62M, LYS63L, LYS63M, LYS69L, LYS69M, LYS81L, LYS84L, LYS91M, MET101L, MET37M, MET68L, MET68M, PHE25M, PHE48M, PRO2L, PRO53M, PRO93M, SER100L, SER26M, SER30M, SER60L, THR15L, THR1L, THR28M, THR41M, THR47M, THR6L, THR71L, THR71M, THR78L, THR78M, THR92M, TRP88L, TYR12L, TYR27M, TYR76L, TYR76M, VAL50L, VAL50M, VAL52M, VAL82L, VAL87L
• L-N: ARG67L, ARG73N
• M-N: ALA102M, ALA32N, ALA38N, ALA46N, ALA64M, ALA64N, ALA75M, ALA80M, ALA95M, ALA95N, ALA97M, ALA98M, ARG35N, ARG67M, ARG67N, ARG73M, ARG73N, ASN103M, ASN4M, ASP59M, ASP70M, ASP70N, ASP7M, CYS86M, CYS9M, GLN3M, GLN49M, GLN49N, GLN56M, GLN56N, GLN61M, GLU11M, GLU29N, GLU36N, GLU51M, GLU51N, GLU66M, GLU66N, GLU79M, GLU83M, GLY33N, GLY45N, HIS57M, HIS94N, ILE24N, ILE39N, ILE40N, ILE58M, ILE5M, ILE65M, ILE65N, ILE74M, ILE74N, ILE96M, ILE99M, LEU31N, LEU72M, LEU72N, LEU77N, LEU85M, LEU8M, LYS23N, LYS34N, LYS62M, LYS62N, LYS63M, LYS63N, LYS69M, LYS69N, LYS81M, LYS84M, LYS91N, MET101M, MET37N, MET68M, MET68N, PHE25N, PHE48N, PRO2M, PRO53N, PRO93N, SER100M, SER26N, SER30N, SER60M, THR15M, THR1M, THR28N, THR41N, THR47N, THR6M, THR71M, THR71N, THR78M, THR78N, THR92N, TRP88M, TYR12M, TYR27N, TYR76M, TYR76N, VAL50M, VAL50N, VAL52N, VAL82M, VAL87M