1S4D

crystal structure analysis of the s-adenosyl-l-methionine dependent uroporphyrinogen-iii c-methyltransferase sumt

• Total interactions analyzed: 66
• Total true interactions: 15
• Strongest Interaction:
  • Chains: H-I
  • Int. Res.: 254
  • Norm. En. per Res.: -3.7998
• Hub Node: D(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-143.5509	-34.8686	-722.577	-900.9965	246	33	35	31001	4	48	48
B-I	0.0	0.6866	-70.2241	-69.5375	40	1	7	2736	0	11	13
D-E	-125.9045	-43.1862	-729.024	-898.1147	245	30	36	31183	9	49	49
D-G	0.0	0.0	-0.0924	-0.0924	3	0	0	32	0	1	1
D-H	0.0	0.0	-25.9602	-25.9602	17	2	0	874	0	1	1
E-G	0.0	0.0	-0.5093	-0.5093	6	0	0	93	0	1	1
E-H	-28.5094	5.4769	-110.07	-133.1024	75	7	6	4630	0	11	13
F-G	-123.5714	2.7219	-740.884	-861.7335	236	39	39	31393	4	45	53
H-I	-149.8682	-54.4868	-760.79	-965.145	254	38	37	32645	6	53	54
H-K	-2.4285	-9.5961	-61.3284	-73.3529	41	5	6	2796	0	11	12
H-L	0.0	27.4836	-7.2999	20.1837	17	3	0	517	0	4	9
I-L	0.0	-1.3017	-30.2461	-31.5478	36	1	0	1545	0	22	18
J-K	-139.5587	-31.8254	-725.783	-897.1671	247	45	38	31590	6	42	46
K-L	0.0	0.0	-1.0279	-1.0279	5	0	0	58	0	0	0
L-M	-134.512	-15.9075	-688.812	-839.2315	224	29	38	29574	5	39	47

Interface residues

• A-B: ALA113A, ALA113B, ALA137A, ALA137B, ALA139A, ALA139B, ALA151A, ALA151B, ALA174A, ALA174B, ALA214A, ALA214B, ALA253A, ALA253B, ALA254A, ALA254B, ALA260A, ALA260B, ALA267A, ALA267B, ALA268A, ALA34A, ALA34B, ALA35A, ALA35B, ALA58B, ALA7A, ARG108A, ARG108B, ARG124A, ARG124B, ARG146A, ARG146B, ARG167A, ARG167B, ARG201B, ARG250A, ARG250B, ARG252A, ARG252B, ARG39A, ARG39B, ARG59B, ASN149A, ASN149B, ASN169A, ASN169B, ASN36A, ASN36B, ASP102A, ASP102B, ASP159B, ASP166A, ASP166B, ASP256A, ASP256B, ASP269A, ASP26A, ASP26B, ASP4B, ASP53B, CYS54A, CYS54B, GLN120A, GLN120B, GLN171A, GLN171B, GLN78A, GLN78B, GLU111A, GLU111B, GLU112A, GLU112B, GLU118A, GLU118B, GLU13B, GLU147A, GLU147B, GLY101A, GLY101B, GLY107A, GLY107B, GLY109A, GLY109B, GLY110A, GLY110B, GLY128A, GLY128B, GLY132A, GLY132B, GLY134A, GLY134B, GLY135A, GLY135B, GLY140A, GLY140B, GLY157A, GLY157B, GLY172A, GLY172B, GLY176A, GLY176B, GLY21A, GLY21B, GLY23A, GLY23B, GLY28A, GLY28B, GLY8A, HIS119A, HIS145A, HIS145B, HIS150A, HIS150B, HIS158A, HIS158B, HIS33A, HIS33B, ILE125A, ILE125B, ILE129A, ILE129B, ILE133A, ILE133B, ILE141A, ILE141B, ILE168A, ILE168B, ILE173A, ILE173B, ILE180A, ILE180B, ILE258A, ILE258B, LEU114A, LEU114B, LEU116A, LEU116B, LEU136A, LEU136B, LEU155A, LEU155B, LEU19A, LEU19B, LEU251A, LEU251B, LEU255A, LEU255B, LEU261A, LEU266A, LEU266B, LEU29A, LEU29B, LEU30A, LEU30B, LEU32A, LEU32B, LEU38A, LEU38B, LEU57A, LEU57B, LEU5B, LEU9A, LEU9B, LYS265A, LYS265B, LYS56A, LYS56B, LYS77A, LYS77B, MET182B, MET184A, MET184B, PHE104A, PHE104B, PHE106A, PHE106B, PHE123A, PHE123B, PHE154A, PHE154B, PHE6A, PHE6B, PRO103A, PRO103B, PRO10A, PRO10B, PRO122A, PRO122B, PRO127A, PRO127B, PRO142A, PRO142B, PRO178A, PRO178B, PRO24A, PRO24B, PRO270A, PRO27A, PRO27B, PRO60A, PRO60B, SER160B, SER175A, SER175B, SER177A, SER177B, THR115A, THR115B, THR130A, THR130B, THR144A, THR144B, THR153A, THR153B, THR156A, THR156B, THR31A, THR31B, TRP170A, TRP170B, TRP18B, TRP257A, TRP257B, TYR138A, TYR138B, TYR183A, TYR183B, VAL105A, VAL105B, VAL117A, VAL117B, VAL121B, VAL126A, VAL126B, VAL143A, VAL143B, VAL148B, VAL152A, VAL152B, VAL179A, VAL179B, VAL181A, VAL181B, VAL248A, VAL248B
• B-I: ALA226B, ALA228B, ALA230B, ALA233B, ALA234B, ALA235B, ALA62I, ALA89I, ALA91I, ARG227B, ARG59I, ARG84I, ARG90I, ARG94I, ASN93I, ASP231B, ASP42I, GLU229B, GLU238B, GLU65I, GLU87I, GLY15I, GLY190B, GLY236B, GLY61I, GLY92I, ILE189B, ILE44I, LEU221B, LEU237B, LEU64I, LEU88I, LYS14I, PRO60I, VAL232B, VAL43I, VAL45I, VAL63I, VAL86I, VAL95I
• D-E: ALA113D, ALA113E, ALA11E, ALA137D, ALA137E, ALA139D, ALA139E, ALA151D, ALA151E, ALA174D, ALA174E, ALA214D, ALA214E, ALA253D, ALA253E, ALA254D, ALA254E, ALA260D, ALA260E, ALA267E, ALA268E, ALA34D, ALA34E, ALA35D, ALA35E, ALA7D, ARG108D, ARG108E, ARG124D, ARG124E, ARG146D, ARG146E, ARG167D, ARG167E, ARG201D, ARG250D, ARG250E, ARG252D, ARG252E, ARG39D, ARG79D, ASN149D, ASN149E, ASN169D, ASN169E, ASN36D, ASN36E, ASP102D, ASP102E, ASP159D, ASP159E, ASP166E, ASP256D, ASP256E, ASP269E, ASP26D, ASP26E, ASP4E, ASP53D, CYS54D, CYS54E, GLN120D, GLN171D, GLN171E, GLN78D, GLN78E, GLU111D, GLU111E, GLU112D, GLU112E, GLU118D, GLU118E, GLU13D, GLU13E, GLU147D, GLU147E, GLY101D, GLY101E, GLY107D, GLY107E, GLY109D, GLY109E, GLY110D, GLY110E, GLY128D, GLY128E, GLY132D, GLY132E, GLY134D, GLY134E, GLY135D, GLY135E, GLY140D, GLY140E, GLY157D, GLY157E, GLY172D, GLY172E, GLY176D, GLY176E, GLY21D, GLY21E, GLY23D, GLY23E, GLY28D, GLY28E, GLY8D, HIS145D, HIS145E, HIS150D, HIS150E, HIS158D, HIS158E, HIS33D, HIS33E, ILE125D, ILE125E, ILE129D, ILE129E, ILE133D, ILE133E, ILE141D, ILE141E, ILE168D, ILE168E, ILE173D, ILE173E, ILE180D, ILE180E, ILE258D, ILE258E, LEU114D, LEU114E, LEU116D, LEU116E, LEU136D, LEU136E, LEU155D, LEU155E, LEU19D, LEU19E, LEU251D, LEU251E, LEU255D, LEU255E, LEU261D, LEU261E, LEU266E, LEU29D, LEU29E, LEU30D, LEU30E, LEU32D, LEU32E, LEU38D, LEU38E, LEU55D, LEU57D, LEU57E, LEU5E, LEU9D, LEU9E, LYS265E, LYS56D, LYS77D, LYS77E, MET182D, MET182E, MET184D, MET184E, PHE104D, PHE104E, PHE106D, PHE106E, PHE123D, PHE123E, PHE154D, PHE154E, PHE6E, PRO103D, PRO103E, PRO10D, PRO10E, PRO122D, PRO122E, PRO127D, PRO127E, PRO142D, PRO142E, PRO178D, PRO178E, PRO24D, PRO24E, PRO270E, PRO27D, PRO27E, SER160D, SER160E, SER16D, SER175D, SER175E, SER177D, SER177E, THR115D, THR115E, THR130D, THR130E, THR144D, THR144E, THR153D, THR153E, THR156D, THR156E, THR31D, THR31E, TRP170D, TRP170E, TRP18D, TRP18E, TRP257D, TRP257E, TYR138D, TYR138E, TYR183D, TYR183E, VAL105D, VAL105E, VAL117D, VAL117E, VAL121D, VAL126D, VAL126E, VAL143D, VAL143E, VAL148D, VAL148E, VAL152D, VAL152E, VAL179D, VAL179E, VAL181D, VAL181E, VAL20E, VAL248D, VAL248E
• D-G: GLN120D, GLU118D, PRO60G
• D-H: ALA174D, ALA260H, ARG264H, ASN169D, ASP262H, GLN171D, GLY172D, GLY176D, GLY199D, GLY200D, GLY259H, GLY263H, ILE173D, LEU261H, LYS265H, SER175D, TRP170D
• E-G: ALA267E, ALA268E, ARG59G, GLY61G, PRO270E, PRO60G
• E-H: ALA139H, ALA174E, ALA191E, ALA194E, ALA198E, ALA208H, ALA219H, ALA226E, ALA228E, ALA230E, ALA230H, ALA233H, ALA234H, ALA235H, ALA253H, ALA260H, ARG167E, ARG201E, ARG227E, ARG227H, ARG252H, ARG264H, ASN169E, ASN195E, ASN212H, ASP166E, ASP204E, ASP231H, ASP256H, ASP262H, CYS211H, GLN171E, GLN217H, GLN218H, GLU222H, GLU229E, GLU238H, GLY162E, GLY172E, GLY176E, GLY190E, GLY199E, GLY200E, GLY236H, GLY259H, GLY263H, HIS188E, ILE141H, ILE173E, ILE189E, ILE192E, ILE197E, ILE258H, LEU196E, LEU221H, LEU237H, LEU261H, LEU266H, LYS187E, LYS265H, PHE209H, PRO165E, PRO203E, PRO216H, PRO239H, SER160E, SER161E, SER175E, THR193E, THR223H, TRP170E, TRP257H, VAL210H, VAL220H, VAL232H
• F-G: ALA113F, ALA113G, ALA131G, ALA137F, ALA137G, ALA139F, ALA139G, ALA151F, ALA151G, ALA174F, ALA174G, ALA214F, ALA214G, ALA253F, ALA253G, ALA254F, ALA254G, ALA260F, ALA260G, ALA267F, ALA267G, ALA268F, ALA34F, ALA34G, ALA35F, ALA35G, ALA7F, ARG108F, ARG108G, ARG124F, ARG124G, ARG146F, ARG146G, ARG167F, ARG167G, ARG201F, ARG250F, ARG252F, ARG252G, ARG264F, ARG264G, ASN149F, ASN149G, ASN169F, ASN169G, ASN36F, ASN36G, ASP102F, ASP102G, ASP159G, ASP166F, ASP256F, ASP256G, ASP262G, ASP269F, ASP26F, ASP26G, CYS54F, CYS54G, GLN120F, GLN120G, GLN171F, GLN171G, GLN78F, GLN78G, GLU111F, GLU111G, GLU112F, GLU112G, GLU118F, GLU118G, GLU13F, GLU147F, GLU147G, GLY101F, GLY101G, GLY107F, GLY107G, GLY109F, GLY109G, GLY110F, GLY110G, GLY128F, GLY128G, GLY132F, GLY132G, GLY134F, GLY134G, GLY135F, GLY135G, GLY140F, GLY140G, GLY157F, GLY157G, GLY172F, GLY172G, GLY176F, GLY176G, GLY21F, GLY21G, GLY23F, GLY23G, GLY28F, GLY28G, GLY8F, GLY8G, HIS145F, HIS145G, HIS150F, HIS150G, HIS158F, HIS158G, HIS33F, HIS33G, ILE125F, ILE125G, ILE129F, ILE129G, ILE133F, ILE133G, ILE141F, ILE141G, ILE168F, ILE168G, ILE173F, ILE173G, ILE180F, ILE180G, ILE258F, ILE258G, LEU114F, LEU114G, LEU116F, LEU116G, LEU136F, LEU136G, LEU155F, LEU155G, LEU19F, LEU19G, LEU251F, LEU251G, LEU255F, LEU255G, LEU266F, LEU266G, LEU29F, LEU29G, LEU30F, LEU30G, LEU32F, LEU32G, LEU38F, LEU38G, LEU57F, LEU57G, LEU9F, LEU9G, LYS265F, LYS265G, LYS77F, LYS77G, MET182G, MET184F, MET184G, PHE104F, PHE104G, PHE106F, PHE106G, PHE123F, PHE123G, PHE154F, PHE154G, PRO103F, PRO103G, PRO10F, PRO10G, PRO122F, PRO122G, PRO127F, PRO127G, PRO142F, PRO142G, PRO165F, PRO165G, PRO178F, PRO178G, PRO24F, PRO24G, PRO27F, PRO27G, SER175F, SER175G, SER177F, SER177G, THR115F, THR115G, THR130F, THR130G, THR144F, THR144G, THR153F, THR153G, THR156F, THR156G, THR31F, THR31G, TRP170F, TRP170G, TRP18F, TRP18G, TRP257F, TRP257G, TYR138F, TYR138G, TYR183F, TYR183G, VAL105F, VAL105G, VAL117F, VAL117G, VAL121G, VAL126F, VAL126G, VAL143F, VAL143G, VAL148F, VAL148G, VAL152F, VAL152G, VAL179F, VAL179G, VAL181F, VAL181G, VAL248F, VAL248G
• H-I: ALA113H, ALA113I, ALA137H, ALA137I, ALA139H, ALA139I, ALA151H, ALA151I, ALA174H, ALA174I, ALA214H, ALA214I, ALA253H, ALA253I, ALA254H, ALA254I, ALA260H, ALA260I, ALA267H, ALA267I, ALA268H, ALA268I, ALA34H, ALA34I, ALA35H, ALA35I, ALA7H, ARG108H, ARG108I, ARG124H, ARG124I, ARG146H, ARG146I, ARG167H, ARG167I, ARG250H, ARG250I, ARG252H, ARG252I, ARG39H, ARG39I, ARG79I, ASN149H, ASN149I, ASN169H, ASN169I, ASN36H, ASN36I, ASP102H, ASP102I, ASP159H, ASP159I, ASP166I, ASP256H, ASP256I, ASP269H, ASP269I, ASP26H, ASP26I, ASP4I, ASP53H, ASP53I, CYS54H, CYS54I, GLN120H, GLN120I, GLN171H, GLN171I, GLN78H, GLN78I, GLU111H, GLU111I, GLU112H, GLU112I, GLU118H, GLU118I, GLU13H, GLU13I, GLU147H, GLU147I, GLY101H, GLY101I, GLY107H, GLY107I, GLY109H, GLY109I, GLY110H, GLY110I, GLY128H, GLY128I, GLY132H, GLY132I, GLY134H, GLY134I, GLY135H, GLY135I, GLY140H, GLY140I, GLY157H, GLY157I, GLY172H, GLY172I, GLY176H, GLY176I, GLY21H, GLY21I, GLY23H, GLY23I, GLY28H, GLY28I, GLY8I, HIS119H, HIS145H, HIS145I, HIS150H, HIS150I, HIS158H, HIS158I, HIS33H, HIS33I, ILE125H, ILE125I, ILE129H, ILE129I, ILE133H, ILE133I, ILE141H, ILE141I, ILE168H, ILE168I, ILE173H, ILE173I, ILE180H, ILE180I, ILE258H, ILE258I, LEU114H, LEU114I, LEU116H, LEU116I, LEU136H, LEU136I, LEU155H, LEU155I, LEU19H, LEU19I, LEU251H, LEU251I, LEU255H, LEU255I, LEU261H, LEU261I, LEU266H, LEU266I, LEU29H, LEU29I, LEU30H, LEU30I, LEU32H, LEU32I, LEU38H, LEU38I, LEU57H, LEU57I, LEU5I, LEU9H, LEU9I, LYS265H, LYS265I, LYS56H, LYS56I, LYS77I, LYS99H, MET182H, MET182I, MET184H, MET184I, PHE104H, PHE104I, PHE106H, PHE106I, PHE123H, PHE123I, PHE154H, PHE154I, PHE271H, PHE6H, PHE6I, PRO103H, PRO103I, PRO10H, PRO10I, PRO122H, PRO122I, PRO127H, PRO127I, PRO142H, PRO142I, PRO165I, PRO178H, PRO178I, PRO24H, PRO24I, PRO270H, PRO27H, PRO27I, SER160I, SER175H, SER175I, SER177H, SER177I, THR115H, THR115I, THR130H, THR130I, THR144H, THR144I, THR153H, THR153I, THR156H, THR156I, THR31H, THR31I, TRP170H, TRP170I, TRP18H, TRP18I, TRP257H, TRP257I, TYR138H, TYR138I, TYR183H, TYR183I, VAL105H, VAL105I, VAL117H, VAL117I, VAL121H, VAL121I, VAL126H, VAL126I, VAL143H, VAL143I, VAL148H, VAL148I, VAL152H, VAL152I, VAL179H, VAL179I, VAL181H, VAL181I, VAL20H, VAL248H, VAL248I
• H-K: ALA226K, ALA228K, ALA230K, ALA233K, ALA234K, ALA235K, ALA41H, ALA62H, ALA89H, ALA91H, ARG227K, ARG59H, ARG84H, ARG90H, ARG94H, ASN93H, ASP231K, ASP42H, GLU229K, GLU238K, GLU65H, GLU87H, GLY15H, GLY190K, GLY236K, GLY61H, GLY92H, ILE189K, ILE44H, LEU221K, LEU237K, LEU64H, LEU88H, LYS14H, PRO60H, VAL232K, VAL43H, VAL45H, VAL63H, VAL86H, VAL95H
• H-L: ALA41L, ARG108H, ARG167H, ARG39L, ARG59L, ARG79H, ARG94L, ASP159H, ASP42L, GLN40L, GLU111H, GLY61L, ILE168H, LEU64L, LYS77H, PRO60L, VAL63L
• I-L: ALA267I, ALA268I, ALA62L, ALA89L, ALA91L, ARG146I, ARG201I, ARG250I, ARG59L, ARG84L, ARG90L, ARG94L, ASN149I, ASN93L, ASP204I, ASP269I, ASP42L, GLU147I, GLU205I, GLU247I, GLU87L, GLY15L, GLY200I, GLY61L, GLY92L, HIS150I, LEU251I, LEU88L, LYS14L, PRO178I, PRO203I, PRO206I, SER202I, VAL148I, VAL43L, VAL63L
• J-K: ALA113J, ALA113K, ALA137J, ALA137K, ALA139J, ALA139K, ALA151J, ALA151K, ALA174J, ALA174K, ALA214J, ALA214K, ALA253J, ALA253K, ALA254J, ALA254K, ALA260J, ALA260K, ALA267J, ALA268J, ALA34J, ALA34K, ALA35J, ALA35K, ALA58J, ALA7J, ALA7K, ARG108J, ARG108K, ARG124J, ARG124K, ARG146J, ARG146K, ARG167J, ARG167K, ARG250J, ARG250K, ARG252J, ARG252K, ARG39J, ARG39K, ARG59J, ARG79K, ASN149J, ASN149K, ASN169J, ASN169K, ASN36J, ASN36K, ASP102J, ASP102K, ASP159J, ASP159K, ASP166K, ASP256J, ASP256K, ASP26J, ASP26K, ASP53J, ASP53K, CYS54J, CYS54K, GLN120K, GLN171J, GLN171K, GLN78J, GLN78K, GLU111J, GLU111K, GLU112J, GLU112K, GLU118J, GLU118K, GLU13J, GLU13K, GLU147J, GLU147K, GLY101J, GLY101K, GLY107J, GLY107K, GLY109J, GLY109K, GLY110J, GLY110K, GLY128J, GLY128K, GLY132J, GLY132K, GLY134J, GLY134K, GLY135J, GLY135K, GLY140J, GLY140K, GLY157J, GLY157K, GLY172J, GLY172K, GLY176J, GLY176K, GLY21J, GLY21K, GLY23J, GLY23K, GLY28J, GLY28K, GLY8J, GLY8K, HIS119K, HIS145J, HIS145K, HIS150J, HIS150K, HIS158J, HIS158K, HIS33J, HIS33K, ILE125J, ILE125K, ILE129J, ILE129K, ILE133J, ILE133K, ILE141J, ILE141K, ILE168J, ILE168K, ILE173J, ILE173K, ILE180J, ILE180K, ILE258J, ILE258K, LEU114J, LEU114K, LEU116J, LEU116K, LEU136J, LEU136K, LEU155J, LEU155K, LEU19J, LEU19K, LEU251J, LEU251K, LEU255J, LEU255K, LEU261J, LEU266J, LEU29J, LEU29K, LEU30J, LEU30K, LEU32J, LEU32K, LEU38J, LEU38K, LEU55J, LEU57J, LEU57K, LEU5K, LEU9J, LEU9K, LYS265J, LYS56J, LYS56K, LYS77J, LYS77K, LYS99K, MET182K, MET184J, MET184K, PHE104J, PHE104K, PHE106J, PHE106K, PHE123J, PHE123K, PHE154J, PHE154K, PHE6J, PHE6K, PRO103J, PRO103K, PRO10J, PRO10K, PRO122J, PRO122K, PRO127J, PRO127K, PRO142J, PRO142K, PRO178J, PRO178K, PRO24J, PRO24K, PRO27J, PRO27K, PRO60J, SER160K, SER16K, SER175J, SER175K, SER177J, SER177K, THR115J, THR115K, THR130J, THR130K, THR144J, THR144K, THR153J, THR153K, THR156J, THR156K, THR31J, THR31K, TRP170J, TRP170K, TRP18J, TRP18K, TRP257J, TRP257K, TYR138J, TYR138K, TYR183J, TYR183K, VAL105J, VAL105K, VAL117J, VAL117K, VAL121K, VAL126J, VAL126K, VAL143J, VAL143K, VAL148J, VAL148K, VAL152J, VAL152K, VAL179J, VAL179K, VAL181J, VAL181K, VAL248J, VAL248K
• K-L: GLY71K, GLY71L, GLY72K, GLY72L, PRO74K
• L-M: ALA113L, ALA113M, ALA11L, ALA137L, ALA137M, ALA139L, ALA139M, ALA151L, ALA151M, ALA174L, ALA174M, ALA214L, ALA214M, ALA253L, ALA253M, ALA254L, ALA254M, ALA260L, ALA260M, ALA267M, ALA268M, ALA34L, ALA34M, ALA35L, ALA35M, ALA7L, ARG108L, ARG108M, ARG124L, ARG124M, ARG146L, ARG146M, ARG167L, ARG167M, ARG250L, ARG252L, ARG252M, ARG39L, ARG79M, ASN149L, ASN149M, ASN169L, ASN169M, ASN36L, ASN36M, ASP102L, ASP102M, ASP159M, ASP166L, ASP256L, ASP256M, ASP269M, ASP26L, ASP26M, CYS54L, CYS54M, GLN120L, GLN171L, GLN171M, GLN78L, GLN78M, GLU111L, GLU111M, GLU112L, GLU112M, GLU118L, GLU118M, GLU13L, GLU147L, GLU147M, GLY101L, GLY107L, GLY107M, GLY109L, GLY109M, GLY110L, GLY110M, GLY128L, GLY128M, GLY132L, GLY132M, GLY134L, GLY134M, GLY135L, GLY135M, GLY140L, GLY140M, GLY157L, GLY157M, GLY172L, GLY172M, GLY176L, GLY176M, GLY21L, GLY21M, GLY23L, GLY23M, GLY28L, GLY28M, HIS145L, HIS145M, HIS150L, HIS150M, HIS158L, HIS158M, HIS33L, HIS33M, ILE125L, ILE125M, ILE129L, ILE129M, ILE133L, ILE133M, ILE141L, ILE141M, ILE168L, ILE168M, ILE173L, ILE173M, ILE180L, ILE180M, ILE258L, ILE258M, LEU114L, LEU114M, LEU116L, LEU116M, LEU136L, LEU136M, LEU155L, LEU155M, LEU19L, LEU19M, LEU251L, LEU251M, LEU255L, LEU255M, LEU261M, LEU266M, LEU29L, LEU29M, LEU30L, LEU30M, LEU32L, LEU32M, LEU38M, LEU57L, LEU57M, LEU9L, LYS265M, LYS77L, LYS77M, MET182L, MET182M, MET184L, PHE104L, PHE104M, PHE106L, PHE106M, PHE123L, PHE123M, PHE154L, PHE154M, PRO103L, PRO103M, PRO10L, PRO10M, PRO122L, PRO122M, PRO127L, PRO127M, PRO142L, PRO142M, PRO178L, PRO178M, PRO24L, PRO24M, PRO27L, PRO27M, SER16L, SER175L, SER175M, SER177L, SER177M, THR115L, THR115M, THR130L, THR130M, THR144L, THR144M, THR153L, THR153M, THR156L, THR156M, THR31L, THR31M, TRP170L, TRP170M, TRP18L, TRP18M, TRP257L, TRP257M, TYR138L, TYR138M, TYR183L, TYR183M, VAL105L, VAL105M, VAL117L, VAL117M, VAL121L, VAL126L, VAL126M, VAL143L, VAL143M, VAL148L, VAL152L, VAL152M, VAL179L, VAL179M, VAL181L, VAL181M, VAL248L, VAL248M