1RZI

crystal structure of human anti-hiv-1 gp120-reactive antibody 47e fab

• Total interactions analyzed: 120
• Total true interactions: 40
• Strongest Interaction:
  • Chains: K-L
  • Int. Res.: 182
  • Norm. En. per Res.: -2.4934
• Hub Node: F(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-9.3387	-4.3521	-419.296	-432.9868	188	33	8	17744	0	17	17
A-D	0.0	0.0	-0.0536	-0.0536	4	0	0	21	0	0	0
A-M	-105.506	3.8425	-282.092	-383.7555	154	27	8	12818	1	23	30
A-N	0.0	0.0	-17.9169	-17.9169	22	1	0	942	0	1	0
B-M	0.0	0.0	-16.5129	-16.5129	24	0	0	1082	0	1	0
B-N	0.0	2.2262	-24.6611	-22.4349	28	9	0	1364	0	6	9
C-D	-37.0623	-5.2972	-414.358	-456.7175	190	36	9	17138	0	19	18
C-H	0.0	0.0	-0.0032	-0.0032	3	0	0	2	0	0	0
C-O	-105.6849	10.4189	-239.916	-335.182	150	32	8	11774	0	24	31
C-P	0.0	0.0	-20.4125	-20.4125	27	0	0	1120	0	3	2
D-M	0.0	-9.7913	-15.8038	-25.5952	24	0	0	1057	1	7	10
D-N	0.0	0.0	-60.254	-60.254	48	7	0	2877	0	9	11
D-O	0.0	0.0	-10.2479	-10.2479	21	0	0	731	0	1	0
D-P	0.0	3.0648	-29.0389	-25.9741	25	3	0	1251	0	6	10
E-F	-8.3774	-9.1903	-425.172	-442.7397	199	23	9	17598	0	20	16
E-I	-57.8157	15.8902	-244.693	-286.6184	152	38	7	12114	2	25	32
E-J	0.0	0.0	-17.1636	-17.1636	24	0	0	1133	0	1	0
E-M	-11.9766	-20.2397	-42.4453	-74.6616	34	4	0	2078	0	4	3
F-G	0.0	0.0	-0.0287	-0.0287	4	0	0	16	0	0	0
F-I	0.0	0.0	-10.5869	-10.5869	20	0	0	704	0	1	1
F-J	0.0	4.3989	-15.3717	-10.9728	22	6	0	1048	0	6	10
F-K	0.0	-10.8899	-24.3443	-35.2342	26	0	0	1369	0	7	9
F-L	-6.3809	0.0	-48.425	-54.8059	45	8	0	2602	0	9	13
F-N	-4.6371	0.0	-6.9474	-11.5845	9	3	0	256	0	0	0
F-P	0.0	0.0	-5.2011	-5.2011	17	0	0	507	0	0	1
G-H	0.0	-7.5141	-357.791	-365.3051	181	28	6	16233	0	15	17
G-K	-38.0316	15.1663	-261.542	-284.4073	153	21	8	12179	1	24	30
G-L	0.0	0.0	-11.6723	-11.6723	23	1	0	834	0	1	0
G-O	-2.3376	0.0	-48.9967	-51.3343	36	5	1	2589	0	0	1
G-P	0.0	0.0	-0.002	-0.002	2	0	0	2	0	0	0
H-K	-7.6375	0.0	-27.9303	-35.5678	26	2	0	1396	0	1	0
H-L	0.0	6.8741	-23.8272	-16.9531	24	3	0	1048	0	7	9
H-O	0.0	0.0	-0.2018	-0.2018	6	0	0	40	0	0	0
I-J	-5.0427	-12.2587	-393.703	-411.0044	184	23	8	16954	0	16	16
J-L	0.0	0.0	-13.1975	-13.1975	32	5	0	925	0	3	8
K-L	-22.4659	-7.5258	-423.813	-453.8047	182	30	9	17149	0	17	16
K-P	0.0	0.0	-1.2483	-1.2483	3	0	0	101	0	0	0
M-N	-19.4591	-5.8129	-418.262	-443.534	187	28	9	17296	0	16	17
N-P	-11.9115	0.0	-19.6369	-31.5484	35	4	0	965	0	4	6
O-P	-10.2551	-6.1469	-431.787	-448.1889	190	28	8	17919	1	16	17

Interface residues

• A-B: ALA125B, ALA130A, ALA136B, ALA137B, ALA168B, ALA193A, ALA33B, ALA40B, ALA50A, ALA51A, ALA57B, ALA60B, ALA93B, ARG142A, ARG38B, ASN137A, ASN138A, ASN210A, ASN34A, ASN58B, ASP101B, ASP122A, ASP144B, ASP167A, ASP170A, CYS134A, CYS140B, CYS88A, CYS92B, GLN100A, GLN105B, GLN124A, GLN160A, GLN166A, GLN171B, GLN37A, GLN38A, GLN39B, GLN43B, GLN55A, GLN61B, GLN64B, GLN6A, GLN6B, GLN89A, GLN90A, GLU123A, GLU161A, GLU165A, GLU213A, GLU46B, GLY100B, GLY101A, GLY104B, GLY106B, GLY139B, GLY157A, GLY162B, GLY41A, GLY42B, GLY44B, GLY49B, GLY50B, GLY95B, GLY99A, HIS100B, HIS164B, HIS96A, ILE117A, ILE2A, ILE34B, ILE48A, LEU124B, LEU125A, LEU135A, LEU136A, LEU138B, LEU141B, LEU170B, LEU175A, LEU175B, LEU178B, LEU181A, LEU33A, LEU45B, LEU46A, LEU47A, LEU4B, LYS117B, LYS129B, LYS143B, LYS169A, LYS207A, LYS209B, LYS39A, LYS42A, LYS45A, LYS94B, MET100B, MET48B, PHE116A, PHE118A, PHE122B, PHE139A, PHE166B, PHE209A, PHE63B, PHE91B, PHE98A, PRO119A, PRO120A, PRO123B, PRO126B, PRO167B, PRO40A, PRO44A, SER114A, SER120B, SER121A, SER127A, SER127B, SER128B, SER130B, SER131A, SER132B, SER159A, SER161B, SER162A, SER172B, SER173B, SER174A, SER176A, SER177A, SER177B, SER179B, SER180B, SER208A, SER31A, SER35B, SER53A, SER56A, SER91A, SER93A, SER95A, THR107B, THR129A, THR131B, THR135B, THR160B, THR164A, THR165B, THR172A, THR178A, THR180A, THR183B, THR206A, THR85A, THR94A, THR97A, TRP103B, TRP35A, TRP36B, TRP47B, TYR173A, TYR176B, TYR192A, TYR32A, TYR36A, TYR49A, TYR59B, TYR87A, TYR92A, VAL102B, VAL115A, VAL121B, VAL132A, VAL133A, VAL142B, VAL163A, VAL163B, VAL169B, VAL181B, VAL182B, VAL184B, VAL211B, VAL37B, VAL43A, VAL89B
• A-D: GLY68A, PHE54D, SER28A, THR69A
• A-M: ALA130A, ALA130M, ALA13A, ALA13M, ALA144A, ALA144M, ALA153A, ALA153M, ARG108A, ARG142A, ARG142M, ARG18A, ARG18M, ARG24A, ARG24M, ASN152A, ASN152M, ASN158A, ASN158M, ASP151A, ASP151M, ASP17A, ASP17M, ASP185A, ASP185M, ASP70A, ASP70M, CYS23A, CYS23M, GLN100A, GLN147A, GLN147M, GLN155A, GLN155M, GLN160A, GLN160M, GLN199A, GLN199M, GLN6A, GLN6M, GLU105A, GLU105M, GLU143A, GLU143M, GLU161A, GLU161M, GLU195A, GLU195M, GLY101M, GLY157A, GLY157M, GLY16A, GLY200A, GLY200M, GLY66A, GLY66M, HIS189A, HIS189M, HIS198A, HIS198M, ILE21A, ILE21M, ILE75A, ILE75M, LEU104A, LEU104M, LEU11A, LEU11M, LEU154A, LEU154M, LEU179A, LEU179M, LEU181A, LEU181M, LEU201A, LEU201M, LEU73A, LEU73M, LEU78A, LEU78M, LYS103M, LYS107A, LYS107M, LYS145A, LYS145M, LYS149A, LYS149M, LYS188M, PHE71A, PHE71M, PRO141A, PRO141M, PRO204A, PRO204M, PRO8A, PRO8M, SER10A, SER10M, SER12A, SER12M, SER131A, SER131M, SER14A, SER14M, SER156A, SER156M, SER159A, SER159M, SER182A, SER182M, SER202A, SER202M, SER203A, SER203M, SER65A, SER65M, SER76A, SER7A, SER7M, THR102A, THR102M, THR129A, THR129M, THR178A, THR178M, THR180A, THR180M, THR197A, THR197M, THR20A, THR20M, THR22A, THR22M, THR5A, THR5M, THR72A, THR72M, THR74A, THR74M, TRP148A, TRP148M, TRP35A, TRP35M, TYR140A, TYR140M, VAL110A, VAL110M, VAL146A, VAL146M, VAL150A, VAL150M, VAL196A, VAL19A, VAL19M
• A-N: ALA25A, ARG24A, ARG83N, ASP70A, GLN171N, GLN27A, GLN3A, GLN6A, GLU85N, GLY174N, ILE2A, LEU170N, LYS143N, MET4A, PRO14N, SER113N, SER172N, SER173N, SER26A, SER84N, THR5A, THR69A
• B-M: ALA112B, ALA114B, ALA25M, ARG24M, ARG83B, ASP70M, CYS23M, GLN171B, GLN27M, GLN3M, GLU85B, GLY174B, ILE2M, LEU170B, LYS143B, MET4M, PRO14B, SER113B, SER172B, SER173B, SER26M, SER84B, THR5M, THR69M
• B-N: ALA60B, ALA60N, ARG66B, ARG66N, ARG83B, ARG83N, ASP86N, GLN61B, GLN61N, GLN64B, GLN64N, GLU46N, GLU85B, GLU85N, GLY15B, GLY15N, LEU82B, LEU82N, LYS62B, LYS62N, PHE63B, PHE63N, PRO14B, PRO14N, SER82B, SER82N, SER84B, SER84N
• C-D: ALA125D, ALA130C, ALA136D, ALA137D, ALA168D, ALA193C, ALA33D, ALA40D, ALA50C, ALA51C, ALA60D, ALA93D, ARG142C, ARG38D, ASN137C, ASN138C, ASN210C, ASN34C, ASN58D, ASP101D, ASP122C, ASP144D, ASP167C, ASP170C, ASP1C, CYS134C, CYS140D, CYS88C, CYS92D, GLN100C, GLN105D, GLN124C, GLN160C, GLN171D, GLN37C, GLN38C, GLN39D, GLN3C, GLN3D, GLN43D, GLN55C, GLN61D, GLN89C, GLN90C, GLU123C, GLU161C, GLU165C, GLU213C, GLU46D, GLY100D, GLY101C, GLY104D, GLY106D, GLY128C, GLY133D, GLY139D, GLY162D, GLY41C, GLY42D, GLY44D, GLY49D, GLY50D, GLY95D, GLY96D, GLY99C, HIS100D, HIS164D, HIS96C, ILE117C, ILE2C, ILE34D, ILE48C, ILE52D, LEU124D, LEU125C, LEU135C, LEU136C, LEU138D, LEU141D, LEU170D, LEU175C, LEU178D, LEU179C, LEU181C, LEU33C, LEU45D, LEU46C, LEU47C, LEU4D, LYS126C, LYS129D, LYS143D, LYS169C, LYS207C, LYS209D, LYS210D, LYS39C, LYS42C, LYS45C, LYS62D, LYS94D, MET100D, MET48D, PHE116C, PHE118C, PHE122D, PHE139C, PHE166D, PHE209C, PHE91D, PHE98C, PRO113C, PRO119C, PRO120C, PRO123D, PRO126D, PRO167D, PRO44C, SER114C, SER120D, SER121C, SER127C, SER127D, SER128D, SER130D, SER131C, SER132D, SER159C, SER161D, SER162C, SER168C, SER172D, SER173D, SER174C, SER176C, SER177C, SER177D, SER179D, SER180D, SER208C, SER31C, SER35D, SER53C, SER56C, SER91C, SER93C, SER95C, THR129C, THR131D, THR135D, THR160D, THR164C, THR165D, THR172C, THR178C, THR180C, THR183D, THR206C, THR85C, THR94C, THR97C, TRP103D, TRP35C, TRP36D, TRP47D, TYR173C, TYR192C, TYR32C, TYR36C, TYR49C, TYR59D, TYR86C, TYR87C, TYR92C, VAL102D, VAL115C, VAL121D, VAL132C, VAL133C, VAL163C, VAL163D, VAL169D, VAL181D, VAL182D, VAL184D, VAL191C, VAL211D, VAL37D, VAL43C, VAL89D
• C-H: GLN1H, GLY26H, LYS188C
• C-O: ALA130C, ALA130O, ALA13C, ALA13O, ALA144C, ALA144O, ALA153C, ALA153O, ARG142C, ARG18C, ARG18O, ARG24C, ARG24O, ASN152C, ASN152O, ASN158C, ASN158O, ASP151C, ASP151O, ASP17C, ASP17O, ASP185C, ASP185O, ASP70C, ASP70O, CYS23C, CYS23O, GLN100O, GLN147C, GLN147O, GLN155C, GLN155O, GLN160C, GLN160O, GLN199C, GLN199O, GLN6C, GLN6O, GLU105C, GLU105O, GLU143C, GLU143O, GLU161C, GLU195C, GLU195O, GLY157C, GLY157O, GLY16O, GLY200C, GLY200O, GLY66C, GLY66O, HIS189C, HIS189O, HIS198C, HIS198O, ILE21C, ILE21O, ILE75C, ILE75O, LEU104C, LEU104O, LEU11C, LEU11O, LEU154C, LEU154O, LEU179C, LEU179O, LEU181C, LEU181O, LEU201C, LEU201O, LEU73C, LEU78C, LEU78O, LYS103C, LYS103O, LYS107C, LYS107O, LYS145C, LYS145O, LYS149C, LYS149O, LYS188C, LYS188O, PHE71C, PHE71O, PRO141C, PRO141O, PRO204C, PRO204O, PRO8C, PRO8O, SER10C, SER10O, SER12C, SER12O, SER14C, SER14O, SER156C, SER156O, SER159C, SER159O, SER182C, SER182O, SER202C, SER202O, SER203C, SER203O, SER65C, SER65O, SER76C, SER76O, SER7C, SER7O, THR102C, THR102O, THR109C, THR129C, THR129O, THR178C, THR178O, THR180C, THR180O, THR197C, THR197O, THR20C, THR20O, THR22C, THR22O, THR5C, THR5O, THR69C, THR72C, THR72O, THR74C, THR74O, TRP148C, TRP148O, TRP35C, TRP35O, TYR140C, TYR140O, VAL110C, VAL110O, VAL150C, VAL150O, VAL196C, VAL19C, VAL19O
• C-P: ALA112P, ALA114P, ALA25C, ARG24C, ARG83P, ASP1C, ASP70C, CYS23C, GLN171P, GLN27C, GLN3C, GLN6C, GLU85P, GLY15P, GLY174P, LEU170P, LEU82P, LYS143P, MET4C, PRO14P, SER113P, SER172P, SER173P, SER26C, SER84P, THR5C, THR69C
• D-M: ALA184M, ALA71D, ALA74D, ASP122M, ASP72D, GLN124M, GLU123M, GLU187M, GLU73D, GLY128M, GLY55D, ILE51D, ILE69D, LEU125M, LYS126M, LYS183M, LYS19D, SER127M, THR129M, THR68D, THR70D, THR75D, THR77D, TYR79D
• D-N: ALA114N, ALA57D, ALA60D, ARG66D, ARG83D, ASN199N, ASN204N, ASN58D, ASP208N, GLN61D, GLN64D, GLU81D, GLY118N, GLY15D, GLY65D, HIS200N, ILE69D, LEU175N, LEU82D, LYS117N, LYS13N, LYS19D, LYS206N, LYS209N, LYS62D, PHE122N, PHE146N, PHE63D, PRO119N, PRO147N, PRO202N, SER115N, SER120N, SER16D, SER17D, SER203N, SER56D, SER82D, THR116N, THR205N, THR68D, THR70D, TYR145N, TYR59D, VAL121N, VAL198N, VAL207N, VAL67D
• D-O: ALA25O, ARG24O, ARG83D, ASP70O, GLN171D, GLN27O, GLN3O, GLU85D, GLY174D, ILE2O, LEU170D, LYS143D, MET4O, PRO14D, SER172D, SER173D, SER26O, SER84D, THR5O, THR69O, VAL169D
• D-P: ALA60P, ARG66D, ARG66P, ARG83D, ARG83P, ASP86D, GLN61D, GLN61P, GLN64D, GLN64P, GLU85D, GLU85P, GLY15D, LEU82D, LEU82P, LYS62D, LYS62P, PHE63D, PHE63P, PRO14D, PRO14P, SER82D, SER82P, SER84D, SER84P
• E-F: ALA125F, ALA130E, ALA136F, ALA137F, ALA168F, ALA193E, ALA33F, ALA40F, ALA50E, ALA51E, ALA57F, ALA60F, ALA93F, ARG142E, ARG38F, ASN137E, ASN138E, ASN158E, ASN210E, ASN34E, ASN58F, ASP101F, ASP122E, ASP144F, ASP167E, ASP170E, CYS134E, CYS140F, CYS194E, CYS88E, CYS92F, GLN100E, GLN105F, GLN124E, GLN160E, GLN166E, GLN171F, GLN37E, GLN38E, GLN39F, GLN3E, GLN3F, GLN43F, GLN55E, GLN61F, GLN6F, GLN89E, GLN90E, GLU123E, GLU161E, GLU165E, GLU212F, GLU213E, GLU46F, GLY100F, GLY101E, GLY104F, GLY106F, GLY128E, GLY139F, GLY157E, GLY162F, GLY174F, GLY41E, GLY42F, GLY44F, GLY49F, GLY50F, GLY95F, GLY96F, GLY99E, HIS100F, HIS164F, HIS96E, ILE117E, ILE2E, ILE48E, ILE52F, LEU124F, LEU125E, LEU135E, LEU136E, LEU138F, LEU141F, LEU170F, LEU175E, LEU175F, LEU178F, LEU179E, LEU181E, LEU189F, LEU33E, LEU45F, LEU46E, LEU47E, LEU4F, LYS103E, LYS126E, LYS129F, LYS143F, LYS169E, LYS207E, LYS209F, LYS210F, LYS214F, LYS39E, LYS42E, LYS45E, LYS62F, LYS94F, MET100F, MET48F, PHE116E, PHE118E, PHE122F, PHE139E, PHE166F, PHE209E, PHE63F, PHE91F, PHE98E, PRO119E, PRO120E, PRO123F, PRO126F, PRO167F, PRO213F, PRO40E, PRO44E, SER114E, SER120F, SER121E, SER127E, SER127F, SER128F, SER130F, SER131E, SER132F, SER159E, SER161F, SER162E, SER168E, SER172F, SER173F, SER174E, SER176E, SER177E, SER177F, SER179F, SER180F, SER208E, SER31E, SER35F, SER56E, SER91E, SER93E, SER95E, THR129E, THR131F, THR135F, THR160F, THR164E, THR165F, THR172E, THR178E, THR180E, THR183F, THR206E, THR85E, THR94E, THR97E, TRP103F, TRP35E, TRP36F, TRP47F, TYR173E, TYR192E, TYR32E, TYR36E, TYR49E, TYR59F, TYR87E, TYR92E, VAL102F, VAL115E, VAL121F, VAL132E, VAL133E, VAL142F, VAL163E, VAL163F, VAL169F, VAL181F, VAL182F, VAL184F, VAL211F, VAL37F, VAL43E, VAL89F
• E-I: ALA130E, ALA130I, ALA13E, ALA13I, ALA144E, ALA144I, ALA153E, ALA153I, ALA184I, ARG108E, ARG142E, ARG18E, ARG18I, ARG24E, ARG24I, ASN152E, ASN152I, ASN158E, ASN158I, ASP151E, ASP151I, ASP17E, ASP17I, ASP185E, ASP185I, ASP70E, ASP70I, CYS23E, CYS23I, GLN100E, GLN147E, GLN147I, GLN155E, GLN155I, GLN160E, GLN160I, GLN199E, GLN199I, GLN6E, GLN6I, GLU105E, GLU105I, GLU143E, GLU143I, GLU161I, GLU195E, GLU195I, GLY157E, GLY157I, GLY16E, GLY16I, GLY200E, GLY200I, GLY66E, GLY66I, HIS189E, HIS189I, HIS198E, HIS198I, ILE21E, ILE21I, ILE75E, ILE75I, LEU104E, LEU104I, LEU11E, LEU11I, LEU154E, LEU154I, LEU179E, LEU179I, LEU181E, LEU181I, LEU201E, LEU201I, LEU73I, LEU78E, LEU78I, LYS103E, LYS103I, LYS107E, LYS107I, LYS145E, LYS145I, LYS149E, LYS149I, LYS188E, PHE71E, PHE71I, PHE83E, PRO141E, PRO141I, PRO204E, PRO204I, PRO8E, PRO8I, SER10E, SER10I, SER12E, SER12I, SER131E, SER14E, SER14I, SER156E, SER156I, SER159E, SER159I, SER182E, SER182I, SER202E, SER202I, SER203E, SER203I, SER65I, SER76I, SER7E, SER7I, THR102E, THR102I, THR129E, THR129I, THR178E, THR178I, THR180E, THR180I, THR197E, THR197I, THR20E, THR20I, THR22E, THR22I, THR5E, THR5I, THR72E, THR72I, THR74E, THR74I, TRP148E, TRP148I, TRP35E, TRP35I, TYR140E, TYR140I, VAL110E, VAL110I, VAL146E, VAL146I, VAL150E, VAL150I, VAL15I, VAL19E, VAL19I
• E-J: ALA112J, ALA114J, ALA25E, ARG24E, ARG83J, ASP70E, CYS23E, GLN171J, GLN27E, GLN3E, GLN6E, GLU85J, GLY174J, ILE2E, LEU170J, MET4E, PRO14J, SER113J, SER172J, SER173J, SER26E, SER84J, THR5E, THR69E
• E-M: ARG61E, ARG61M, ASP82E, ASP82M, GLN79E, GLN79M, GLU81E, GLU81M, GLY16E, GLY16M, GLY57M, ILE75E, LEU54E, LEU78E, LEU78M, LYS39E, LYS39M, LYS45E, PHE62E, PHE62M, PRO59E, PRO59M, PRO80E, PRO80M, SER60E, SER60M, SER76E, SER76M, SER77E, SER77M, VAL15E, VAL15M, VAL58E, VAL58M
• F-G: GLY68G, PHE54F, SER28G, THR69G
• F-I: ALA25I, ARG24I, ASP70I, CYS23I, GLN171F, GLN27I, GLN3I, GLU85F, GLY174F, LEU170F, LYS143F, MET4I, PRO14F, SER113F, SER172F, SER173F, SER26I, SER84F, THR5I, THR69I
• F-J: ALA60F, ALA60J, ARG66F, ARG66J, ARG83F, ARG83J, GLN61F, GLN61J, GLN64F, GLN64J, GLU85F, GLU85J, LEU82J, LYS62F, LYS62J, PHE63F, PHE63J, PRO14J, SER82F, SER82J, SER84F, SER84J
• F-K: ALA184K, ALA71F, ALA74F, ASP122K, ASP72F, GLN124K, GLU123K, GLU187K, GLU73F, GLU81F, GLY128K, GLY55F, ILE51F, ILE69F, LEU125K, LYS126K, LYS183K, LYS19F, SER127K, THR129K, THR68F, THR70F, THR75F, THR77F, THR78F, TYR79F
• F-L: ALA114L, ALA57F, ARG66F, ARG83F, ASN204L, ASN58F, ASP144L, ASP208L, GLN61F, GLN64F, GLU81F, GLY118L, GLY15F, GLY65F, HIS200L, LEU175L, LEU82F, LYS117L, LYS13L, LYS19F, LYS206L, LYS209L, LYS62F, PHE122L, PHE146L, PHE63F, PRO119L, PRO147L, PRO202L, SER115L, SER120L, SER16F, SER17F, SER203L, SER56F, SER82F, THR116L, THR205L, THR68F, THR70F, TYR145L, TYR59F, VAL121L, VAL207L, VAL67F
• F-N: GLN1F, GLN1N, GLN3F, GLN3N, GLY26N, LEU5N, SER25N, VAL2F, VAL2N
• F-P: ALA74P, GLU73F, GLU73P, GLY26F, GLY27F, PHE29F, PHE29P, PRO52P, SER30F, SER30P, SER31F, SER31P, SER76P, THR28F, THR28P, TYR32F, VAL53P
• G-H: ALA125H, ALA130G, ALA136H, ALA137H, ALA168H, ALA33H, ALA40H, ALA50G, ALA51G, ALA57H, ALA60H, ALA93H, ARG142G, ARG38H, ASN137G, ASN138G, ASN210G, ASN34G, ASN58H, ASP101H, ASP122G, ASP144H, ASP167G, ASP170G, CYS134G, CYS140H, CYS88G, CYS92H, GLN100G, GLN105H, GLN124G, GLN160G, GLN171H, GLN37G, GLN38G, GLN39H, GLN3G, GLN43H, GLN55G, GLN61H, GLN64H, GLN6H, GLN89G, GLN90G, GLU123G, GLU161G, GLU165G, GLU213G, GLU46H, GLY100H, GLY101G, GLY104H, GLY106H, GLY133H, GLY139H, GLY157G, GLY162H, GLY41G, GLY42H, GLY44H, GLY49H, GLY50H, GLY95H, GLY96H, GLY99G, HIS100H, HIS164H, HIS96G, ILE117G, ILE2G, ILE34H, ILE48G, LEU124H, LEU125G, LEU135G, LEU136G, LEU138H, LEU141H, LEU170H, LEU175G, LEU175H, LEU178H, LEU179G, LEU181G, LEU33G, LEU45H, LEU46G, LEU47G, LYS126G, LYS129H, LYS143H, LYS169G, LYS207G, LYS209H, LYS39G, LYS42G, LYS45G, LYS94H, MET100H, MET48H, PHE116G, PHE118G, PHE122H, PHE139G, PHE166H, PHE209G, PHE91H, PHE98G, PRO119G, PRO120G, PRO123H, PRO126H, PRO167H, PRO40G, PRO44G, SER114G, SER120H, SER121G, SER127G, SER127H, SER128H, SER130H, SER131G, SER132H, SER159G, SER161H, SER162G, SER172H, SER173H, SER174G, SER176G, SER177G, SER177H, SER179H, SER180H, SER208G, SER31G, SER35H, SER53G, SER56G, SER56H, SER91G, SER93G, SER95G, THR129G, THR131H, THR135H, THR160H, THR164G, THR165H, THR172G, THR178G, THR180G, THR183H, THR85G, THR94G, THR97G, TRP103H, TRP35G, TRP36H, TRP47H, TYR173G, TYR32G, TYR36G, TYR49G, TYR59H, TYR87G, VAL102H, VAL115G, VAL121H, VAL132G, VAL133G, VAL163G, VAL163H, VAL169H, VAL181H, VAL182H, VAL211H, VAL37H, VAL43G, VAL89H
• G-K: ALA130G, ALA130K, ALA13G, ALA13K, ALA144G, ALA144K, ALA153G, ALA153K, ALA184K, ARG108G, ARG142K, ARG18G, ARG18K, ARG24G, ARG24K, ASN152G, ASN152K, ASN158G, ASN158K, ASP151G, ASP151K, ASP17G, ASP17K, ASP185G, ASP185K, ASP70G, ASP70K, CYS23G, CYS23K, CYS88G, GLN100G, GLN100K, GLN147G, GLN147K, GLN155G, GLN155K, GLN160G, GLN160K, GLN199G, GLN199K, GLN6G, GLN6K, GLU105G, GLU105K, GLU143G, GLU143K, GLU161G, GLU161K, GLU195G, GLU195K, GLY101K, GLY157G, GLY157K, GLY16G, GLY16K, GLY200G, GLY200K, GLY66G, GLY66K, HIS189G, HIS189K, HIS198G, HIS198K, ILE21G, ILE21K, ILE75G, ILE75K, LEU104G, LEU104K, LEU11G, LEU11K, LEU154G, LEU154K, LEU179G, LEU179K, LEU181G, LEU181K, LEU201G, LEU201K, LEU73G, LEU73K, LEU78G, LEU78K, LYS103G, LYS103K, LYS107G, LYS107K, LYS145G, LYS145K, LYS149G, LYS149K, LYS188K, PHE71G, PRO141G, PRO141K, PRO204G, PRO204K, PRO8G, PRO8K, SER10G, SER10K, SER12G, SER12K, SER14G, SER14K, SER156G, SER156K, SER159G, SER159K, SER182G, SER182K, SER202G, SER202K, SER203G, SER203K, SER65G, SER76G, SER76K, SER7G, SER7K, THR102G, THR102K, THR178G, THR178K, THR180G, THR180K, THR197G, THR197K, THR20G, THR20K, THR22G, THR22K, THR5G, THR5K, THR72G, THR72K, THR74G, THR74K, TRP148G, TRP148K, TRP35G, TRP35K, TYR140G, TYR140K, VAL110G, VAL110K, VAL146G, VAL146K, VAL150G, VAL150K, VAL196G, VAL19G, VAL19K
• G-L: ALA114L, ALA25G, ARG24G, ARG83L, ASP70G, GLN171L, GLN27G, GLN3G, GLU85L, GLY174L, ILE2G, LEU170L, LEU175L, LYS143L, MET4G, PRO14L, SER113L, SER172L, SER173L, SER26G, SER84L, THR5G, THR69G
• G-O: ALA50G, ALA50O, ALA51G, ARG61O, GLN55G, GLN55O, GLY57G, GLY57O, GLY64G, GLY64O, ILE48G, ILE48O, LEU54G, LEU54O, LYS45G, PHE62G, PHE62O, PRO59G, PRO59O, SER31G, SER52G, SER52O, SER53G, SER53O, SER56G, SER56O, SER60G, SER60O, SER63G, SER63O, SER65G, SER76O, TYR49G, TYR49O, VAL58G, VAL58O
• G-P: GLN1P, SER67G
• H-K: ALA112H, ALA114H, ALA25K, ARG24K, ARG83H, ASP70K, CYS23K, GLN171H, GLN27K, GLN3K, GLN6K, GLU85H, GLY174H, ILE2K, LEU170H, LEU175H, LYS143H, MET4K, PRO14H, SER113H, SER172H, SER173H, SER26K, SER84H, THR5K, THR69K
• H-L: ALA60H, ALA60L, ARG66H, ARG66L, ARG83H, ARG83L, GLN61H, GLN61L, GLN64H, GLN64L, GLU46L, GLU85H, GLU85L, GLY15H, LEU82H, LYS62H, LYS62L, PHE63H, PHE63L, PRO14H, SER82H, SER82L, SER84H, SER84L
• H-O: ALA50O, GLY96H, HIS100H, SER52O, SER53O, TYR49O
• I-J: ALA125J, ALA130I, ALA136J, ALA137J, ALA168J, ALA33J, ALA50I, ALA51I, ALA60J, ALA93J, ARG142I, ARG38J, ASN137I, ASN138I, ASN158I, ASN210I, ASN34I, ASN58J, ASP101J, ASP122I, ASP144J, ASP167I, ASP170I, CYS134I, CYS140J, CYS88I, CYS92J, GLN100I, GLN105J, GLN124I, GLN160I, GLN166I, GLN171J, GLN27I, GLN37I, GLN38I, GLN39J, GLN3I, GLN43J, GLN55I, GLN61J, GLN6J, GLN89I, GLN90I, GLU123I, GLU161I, GLU165I, GLU213I, GLU46J, GLY100J, GLY101I, GLY104J, GLY106J, GLY128I, GLY133J, GLY139J, GLY157I, GLY162J, GLY41I, GLY44J, GLY49J, GLY50J, GLY95J, GLY96J, GLY99I, HIS100J, HIS164J, HIS96I, ILE117I, ILE2I, ILE48I, LEU124J, LEU125I, LEU135I, LEU136I, LEU138J, LEU141J, LEU170J, LEU175I, LEU178J, LEU181I, LEU33I, LEU45J, LEU46I, LEU47I, LEU4J, LYS126I, LYS129J, LYS143J, LYS169I, LYS207I, LYS209J, LYS210J, LYS39I, LYS42I, LYS45I, LYS94J, MET100J, MET48J, PHE116I, PHE118I, PHE122J, PHE139I, PHE166J, PHE209I, PHE91J, PHE98I, PRO113I, PRO119I, PRO120I, PRO123J, PRO126J, PRO167J, PRO44I, SER114I, SER120J, SER121I, SER127I, SER127J, SER128J, SER130J, SER131I, SER132J, SER159I, SER161J, SER162I, SER168I, SER172J, SER173J, SER174I, SER176I, SER177I, SER177J, SER179J, SER180J, SER182I, SER208I, SER31I, SER35J, SER53I, SER56I, SER91I, SER93I, SER95I, THR129I, THR131J, THR135J, THR160J, THR164I, THR165J, THR172I, THR178I, THR180I, THR183J, THR85I, THR94I, THR97I, TRP103J, TRP35I, TRP36J, TRP47J, TYR173I, TYR32I, TYR36I, TYR49I, TYR59J, TYR86I, TYR87I, TYR92I, VAL102J, VAL115I, VAL121J, VAL132I, VAL133I, VAL142J, VAL163I, VAL163J, VAL169J, VAL181J, VAL182J, VAL211J, VAL37J, VAL43I, VAL89J
• J-L: ALA60J, ALA74J, ARG66J, ARG83J, ASN199L, ASN204L, ASP72J, GLN3L, GLN61J, GLN64J, GLU81J, GLY65J, GLY8L, HIS200L, LEU5L, LYS12L, LYS19J, LYS201L, LYS206L, LYS23L, LYS62J, PHE63J, PRO202L, SER16J, SER203L, SER56J, SER82J, THR116L, THR205L, THR75J, TYR59J, VAL67J
• K-L: ALA125L, ALA130K, ALA136L, ALA137L, ALA168L, ALA193K, ALA33L, ALA50K, ALA57L, ALA60L, ALA93L, ARG142K, ARG38L, ASN137K, ASN138K, ASN158K, ASN210K, ASN34K, ASN58L, ASP101L, ASP122K, ASP144L, ASP167K, ASP170K, CYS134K, CYS140L, CYS88K, CYS92L, GLN100K, GLN105L, GLN124K, GLN160K, GLN171L, GLN37K, GLN38K, GLN39L, GLN3K, GLN43L, GLN55K, GLN61L, GLN6L, GLN89K, GLN90K, GLU123K, GLU161K, GLU165K, GLU46L, GLY100L, GLY101K, GLY104L, GLY106L, GLY128K, GLY133L, GLY139L, GLY157K, GLY162L, GLY174L, GLY41K, GLY42L, GLY44L, GLY49L, GLY50L, GLY95L, GLY99K, HIS100L, HIS164L, HIS96K, ILE117K, ILE2K, ILE48K, LEU124L, LEU125K, LEU135K, LEU136K, LEU138L, LEU141L, LEU170L, LEU175K, LEU178L, LEU179K, LEU181K, LEU45L, LEU46K, LEU47K, LEU4L, LYS126K, LYS129L, LYS143L, LYS169K, LYS207K, LYS209L, LYS39K, LYS42K, LYS45K, LYS62L, LYS94L, MET100L, MET48L, PHE116K, PHE118K, PHE122L, PHE139K, PHE166L, PHE209K, PHE91L, PHE98K, PRO113K, PRO119K, PRO120K, PRO123L, PRO126L, PRO167L, PRO213L, PRO40K, PRO44K, SER114K, SER120L, SER121K, SER127K, SER127L, SER128L, SER130L, SER131K, SER132L, SER161L, SER162K, SER172L, SER173L, SER174K, SER176K, SER177K, SER177L, SER179L, SER180L, SER208K, SER35L, SER56K, SER91K, SER93K, SER95K, THR129K, THR131L, THR135L, THR160L, THR164K, THR165L, THR172K, THR178K, THR180K, THR183L, THR206K, THR85K, THR94K, THR97K, TRP103L, TRP35K, TRP36L, TRP47L, TYR173K, TYR192K, TYR32K, TYR36K, TYR49K, TYR59L, TYR86K, TYR87K, TYR92K, VAL102L, VAL115K, VAL121L, VAL132K, VAL133K, VAL163K, VAL163L, VAL169L, VAL181L, VAL182L, VAL184L, VAL211L, VAL37L, VAL43K, VAL89L
• K-P: ALA184K, GLN1P, LYS188K
• M-N: ALA125N, ALA130M, ALA136N, ALA137N, ALA168N, ALA193M, ALA33N, ALA50M, ALA60N, ALA93N, ARG142M, ARG38N, ASN137M, ASN138M, ASN158M, ASN210M, ASN34M, ASN58N, ASP101N, ASP122M, ASP144N, ASP167M, ASP170M, CYS134M, CYS140N, CYS88M, CYS92N, GLN100M, GLN105N, GLN124M, GLN160M, GLN171N, GLN37M, GLN38M, GLN39N, GLN3M, GLN43N, GLN55M, GLN61N, GLN64N, GLN6N, GLN89M, GLN90M, GLU123M, GLU161M, GLU165M, GLU212N, GLU213M, GLU46N, GLY100N, GLY101M, GLY104N, GLY106N, GLY133N, GLY139N, GLY157M, GLY162N, GLY41M, GLY42N, GLY44N, GLY49N, GLY50N, GLY95N, GLY96N, GLY99M, HIS100N, HIS164N, HIS96M, ILE117M, ILE2M, ILE48M, LEU124N, LEU125M, LEU135M, LEU136M, LEU138N, LEU141N, LEU170N, LEU175M, LEU178N, LEU179M, LEU181M, LEU45N, LEU46M, LEU47M, LYS117N, LYS126M, LYS129N, LYS143N, LYS169M, LYS207M, LYS209N, LYS210N, LYS39M, LYS42M, LYS45M, LYS62N, LYS94N, MET100N, MET48N, PHE116M, PHE118M, PHE122N, PHE139M, PHE166N, PHE209M, PHE91N, PHE98M, PRO113M, PRO119M, PRO120M, PRO123N, PRO126N, PRO167N, PRO213N, PRO40M, PRO44M, SER114M, SER120N, SER121M, SER127M, SER127N, SER128N, SER130N, SER131M, SER132N, SER159M, SER161N, SER162M, SER172N, SER173N, SER174M, SER176M, SER177M, SER177N, SER179N, SER180N, SER208M, SER35N, SER53M, SER56M, SER91M, SER93M, SER95M, THR129M, THR131N, THR135N, THR164M, THR165N, THR172M, THR178M, THR180M, THR183N, THR206M, THR85M, THR94M, THR97M, TRP103N, TRP35M, TRP36N, TRP47N, TYR173M, TYR192M, TYR32M, TYR36M, TYR49M, TYR59N, TYR86M, TYR87M, TYR92M, VAL102N, VAL115M, VAL121N, VAL132M, VAL133M, VAL142N, VAL163M, VAL163N, VAL169N, VAL181N, VAL182N, VAL184N, VAL191M, VAL211N, VAL37N, VAL43M, VAL89N
• N-P: ALA60P, ALA74P, ARG66P, ARG83P, ASN199N, ASN204N, ASP72P, GLN61P, GLN64P, GLU10N, GLU81P, GLY65P, GLY8N, HIS200N, LEU5N, LYS12N, LYS19P, LYS201N, LYS206N, LYS23N, LYS62P, PHE63P, PRO202N, SER16P, SER17P, SER203N, SER25N, SER56P, SER7N, SER82P, THR116N, THR205N, TYR59P, VAL11N, VAL67P
• O-P: ALA125P, ALA130O, ALA136P, ALA137P, ALA168P, ALA193O, ALA33P, ALA50O, ALA51O, ALA57P, ALA60P, ALA93P, ARG142O, ARG38P, ASN137O, ASN138O, ASN158O, ASN210O, ASN34O, ASN58P, ASP101P, ASP122O, ASP144P, ASP167O, ASP170O, CYS134O, CYS140P, CYS88O, CYS92P, GLN100O, GLN105P, GLN124O, GLN160O, GLN166O, GLN171P, GLN37O, GLN38O, GLN39P, GLN43P, GLN55O, GLN61P, GLN64P, GLN6P, GLN89O, GLN90O, GLU123O, GLU161O, GLU165O, GLU213O, GLU46P, GLY100P, GLY101O, GLY104P, GLY106P, GLY128O, GLY133P, GLY139P, GLY157O, GLY162P, GLY41O, GLY42P, GLY44P, GLY49P, GLY50P, GLY95P, GLY96P, GLY99O, HIS100P, HIS164P, HIS96O, ILE117O, ILE2O, ILE48O, LEU124P, LEU125O, LEU135O, LEU136O, LEU138P, LEU141P, LEU170P, LEU175O, LEU175P, LEU178P, LEU181O, LEU33O, LEU45P, LEU46O, LEU47O, LEU4P, LYS126O, LYS129P, LYS143P, LYS169O, LYS207O, LYS209P, LYS210P, LYS39O, LYS42O, LYS45O, LYS94P, MET100P, MET48P, PHE116O, PHE118O, PHE122P, PHE139O, PHE166P, PHE209O, PHE91P, PHE98O, PRO113O, PRO119O, PRO120O, PRO123P, PRO126P, PRO167P, PRO44O, SER114O, SER120P, SER121O, SER127O, SER127P, SER128P, SER130P, SER131O, SER132P, SER161P, SER162O, SER168O, SER172P, SER173P, SER174O, SER176O, SER177O, SER177P, SER179P, SER180P, SER182O, SER208O, SER31O, SER35P, SER53O, SER56O, SER91O, SER93O, SER95O, THR129O, THR131P, THR135P, THR160P, THR164O, THR165P, THR172O, THR178O, THR180O, THR183P, THR206O, THR85O, THR94O, THR97O, TRP103P, TRP35O, TRP36P, TRP47P, TYR173O, TYR192O, TYR32O, TYR36O, TYR49O, TYR59P, TYR86O, TYR87O, TYR92O, VAL102P, VAL115O, VAL121P, VAL132O, VAL133O, VAL142P, VAL163O, VAL163P, VAL169P, VAL181P, VAL182P, VAL184P, VAL191O, VAL211P, VAL37P, VAL43O, VAL89P