1RYP

crystal structure of the 20s proteasome from yeast at 2.4 angstroms resolution

• Total interactions analyzed: 378
• Total true interactions: 98
• Strongest Interaction:
  • Chains: Q-S
  • Int. Res.: 15
  • Norm. En. per Res.: -5.1697
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-75.3487	-24.6311	-415.404	-515.3838	132	16	13	15834	2	22	27
A-C	0.0	3.3632	-30.7234	-27.3602	17	1	3	1102	0	2	5
A-E	0.0	0.0	-0.035	-0.035	2	0	0	10	0	0	0
A-G	-69.815	-42.9478	-394.901	-507.6638	127	11	9	14611	3	25	27
A-H	-14.9328	-37.0052	-79.1833	-131.1214	46	2	4	3594	2	13	16
A-I	-20.793	-75.7488	-171.42	-267.9618	61	5	1	5998	10	14	21
A-2	-2.3088	-4.963	-10.7367	-18.0085	14	0	0	518	0	3	4
B-C	-42.3547	-14.1389	-400.082	-456.5756	135	16	7	15561	1	23	22
B-D	0.0	-11.7903	-15.5836	-27.3739	12	0	1	609	0	2	2
B-E	0.0	-7.0409	-5.746	-12.7869	7	1	0	219	0	2	1
B-F	0.0	0.0	-11.9173	-11.9173	10	0	0	490	0	1	0
B-G	0.0	0.0	-21.0059	-21.0059	18	4	0	1128	0	0	1
B-I	-52.1007	-35.1851	-168.728	-256.0138	74	9	4	6666	1	17	20
B-J	-14.2269	6.6777	-118.787	-126.3362	56	1	2	4827	1	15	21
C-D	-70.4702	6.3252	-461.447	-525.5919	143	29	8	18383	1	33	36
C-E	-3.7808	-47.4841	-22.4312	-73.6961	16	0	0	931	2	8	6
C-F	0.0	-32.015	-35.4557	-67.4707	20	2	0	1128	2	4	2
C-G	0.0	0.0	-24.588	-24.588	18	0	0	1058	0	1	1
C-I	0.0	24.1754	-5.1318	19.0435	10	0	0	220	0	5	4
C-J	0.0	-7.4544	-108.488	-115.9424	51	2	0	4855	0	17	20
C-K	-17.1293	-35.2043	-133.555	-185.8886	51	7	2	4649	4	20	24
D-E	-61.5176	-50.852	-365.697	-478.0666	126	20	9	14292	2	27	30
D-F	0.0	0.0	-0.073	-0.073	3	0	0	21	0	1	0
D-K	-11.3829	-13.1784	-79.5715	-104.1328	43	9	2	3859	2	17	13
D-L	-32.0647	-41.0907	-59.7209	-132.8763	37	2	1	2568	9	30	24
E-F	-61.1022	-38.824	-300.851	-400.7772	123	17	7	12408	2	34	35
E-G	0.0	0.0	-0.0069	-0.0069	2	0	0	1	0	0	0
E-L	-10.2241	-51.5195	-92.1496	-153.8932	50	4	1	4207	6	27	26
E-M	-15.1564	-39.4124	-131.853	-186.4218	51	2	0	4671	3	31	28
F-G	-77.6504	-27.821	-401.597	-507.0683	133	14	11	14801	2	33	33
F-M	-10.8138	-21.6179	-75.9813	-108.413	42	3	0	3147	2	13	19
F-N	0.0	-23.7539	-132.054	-155.808	54	3	3	5059	1	28	12
G-H	-16.4146	-19.9768	-92.2976	-128.6889	50	1	2	4184	2	14	10
G-N	-17.2357	-79.5613	-93.3765	-190.1735	54	4	2	3946	7	34	22
H-I	-46.4788	-49.3691	-131.299	-227.1469	74	4	3	5188	3	20	12
H-N	-22.7308	-20.4462	-134.362	-177.539	66	2	1	5901	2	22	14
H-V	-41.8052	-19.9576	-193.954	-255.7168	54	15	3	6870	4	10	11
H-2	-108.3857	1.427	-394.015	-500.9736	116	20	9	14280	3	29	30
I-J	-136.8931	-138.3863	-369.044	-644.3234	143	19	13	15175	9	42	36
I-Z	0.0	0.0	-9.5749	-9.5749	7	0	1	480	0	0	0
I-1	-98.7917	-68.4106	-380.692	-547.8943	119	23	5	14802	4	33	40
I-2	0.0	-34.5117	-200.129	-234.6407	92	6	5	9126	1	21	20
J-K	-21.4595	-63.5667	-110.801	-195.8271	74	7	4	5645	4	12	11
J-Z	-76.5903	-53.4496	-266.633	-396.673	91	9	4	9908	5	20	21
J-1	-34.5982	-20.9701	-192.981	-248.5493	73	12	1	7575	3	19	20
K-L	-20.7518	-32.4427	-146.728	-199.9225	69	6	4	6226	4	21	21
K-Y	-51.0718	-9.135	-149.428	-209.6348	58	4	4	6380	2	18	28
K-Z	-31.4984	-44.3942	-206.766	-282.6586	78	7	1	7845	5	19	18
L-M	-46.4549	-46.6254	-178.256	-271.3363	87	11	4	6293	4	25	16
L-W	0.0	0.0	-10.5053	-10.5053	7	0	1	504	0	0	0
L-X	-76.2327	-51.6645	-267.889	-395.7862	92	10	4	9943	5	20	20
L-Y	-33.4869	-47.0669	-207.717	-288.2708	78	12	1	7910	6	20	19
M-N	-44.6224	-29.4666	-223.605	-297.6939	92	10	5	9267	10	27	23
M-W	-82.8746	-69.2555	-381.323	-533.4531	118	21	5	14697	4	34	40
M-X	-36.1688	-22.6614	-179.983	-238.8133	74	15	1	7567	3	19	20
N-O	0.0	0.0	-10.7229	-10.7229	14	1	0	525	0	3	4
N-V	-100.7367	4.9245	-388.89	-484.7023	115	19	9	14200	3	29	30
N-W	-2.1197	-35.1663	-202.832	-240.118	92	3	5	9171	1	21	20
O-P	-83.8669	-25.7869	-423.375	-533.0288	134	16	13	15923	3	22	27
O-Q	0.0	3.5878	-36.0913	-32.5035	18	2	3	1208	0	2	5
O-S	0.0	0.0	-0.0885	-0.0885	2	0	0	18	0	0	0
O-U	-68.7057	-42.9895	-405.746	-517.4412	130	14	9	14834	5	25	27
O-V	-13.2405	-33.3623	-74.1306	-120.7334	46	2	4	3504	2	13	16
O-W	-26.4867	-46.8164	-165.498	-238.8011	60	6	1	5906	9	14	21
P-Q	-42.2938	-13.0686	-401.597	-456.9594	137	15	7	15705	1	24	21
P-R	0.0	-12.7045	-18.3306	-31.0351	12	0	1	640	0	2	2
P-S	-3.3741	-8.1036	-7.2834	-18.761	7	2	0	244	0	3	1
P-T	0.0	0.0	-9.3587	-9.3587	10	0	0	427	0	1	0
P-U	0.0	0.0	-13.9513	-13.9513	16	5	0	1067	0	0	1
P-W	-47.3134	-37.837	-170.199	-255.3494	77	10	3	6673	1	18	21
P-X	-14.1722	1.0409	-119.669	-132.8003	57	0	2	4715	1	16	22
Q-R	-64.2668	5.2952	-441.926	-500.8975	140	29	6	17774	1	33	36
Q-S	-5.9143	-47.6264	-24.0049	-77.5457	15	4	0	943	2	7	6
Q-T	0.0	-32.3653	-31.8018	-64.1671	16	3	0	1056	2	4	2
Q-U	0.0	0.0	-25.9854	-25.9854	17	1	0	1055	0	1	0
Q-W	0.0	24.4057	-5.7932	18.6125	10	0	0	243	0	5	4
Q-X	0.0	-8.352	-111.118	-119.47	51	3	0	4889	0	18	21
Q-Y	-12.0677	-31.965	-135.392	-179.4247	50	11	3	4715	4	21	24
R-S	-48.26	-31.82	-350.021	-430.101	126	17	8	13947	2	25	29
R-T	0.0	0.0	-0.0583	-0.0583	2	0	0	17	0	1	0
R-Y	-15.9079	-11.1808	-78.0994	-105.1881	42	7	2	3777	2	17	13
R-Z	-33.9491	-43.5678	-62.5142	-140.0311	37	3	1	2568	8	31	25
S-T	-59.3815	-38.4672	-298.499	-396.3477	121	16	7	12326	2	35	34
S-U	0.0	0.0	-0.0071	-0.0071	2	0	0	1	0	0	0
S-Z	-7.8492	-37.3137	-92.9015	-138.0643	49	3	1	4173	6	26	24
S-1	-5.0574	-39.7252	-134.141	-178.9236	51	0	0	4667	3	31	29
T-U	-82.8106	-24.3977	-409.868	-517.0763	134	20	11	15163	2	32	32
T-1	-6.0292	-28.7676	-81.3165	-116.1133	43	3	0	3172	1	13	19
T-2	0.0	-28.2084	-136.436	-164.6444	55	6	3	5146	1	28	12
U-V	-12.0886	-18.6722	-93.832	-124.5928	50	2	2	4200	1	14	10
U-2	-15.3317	-77.342	-95.7185	-188.3922	55	5	2	3988	7	34	22
V-W	-44.0961	-47.9986	-126.199	-218.2938	74	3	3	5135	3	20	12
V-2	-25.5189	-20.8816	-141.859	-188.2594	68	4	1	5988	1	22	15
W-X	-137.6733	-141.7073	-376.887	-656.2676	143	22	15	15348	11	42	35
X-Y	-18.6857	-61.8049	-115.37	-195.8606	73	6	4	5794	4	13	11
Y-Z	-28.0961	-30.4225	-142.573	-201.0916	68	5	4	6128	4	21	21
Z-1	-38.197	-48.7692	-166.436	-253.4022	84	8	4	6108	4	25	15
1-2	-52.5653	-27.303	-224.338	-304.2063	94	10	5	9356	10	27	23

Interface residues

• A-B: ALA10A, ALA118A, ALA121B, ALA122A, ALA132A, ALA160A, ALA168A, ALA170A, ALA24B, ALA27B, ALA44A, ALA56B, ARG120A, ARG128B, ARG131A, ARG24A, ARG46A, ARG4B, ARG83B, ARG90B, ASN123A, ASN181A, ASN184A, ASP115A, ASP13A, ASP158A, ASP192A, ASP22B, ASP3B, ASP81B, ASP87B, GLN126A, GLN130A, GLN175A, GLN176A, GLN20B, GLN30B, GLU183A, GLU22A, GLU59B, GLY125B, GLY126B, GLY131B, GLY161A, GLY165A, GLY19B, GLY23A, GLY79B, HIS15A, HIS185A, ILE117B, ILE127A, ILE154A, ILE16A, ILE178A, ILE18A, ILE21B, LEU124A, LEU150A, LEU182A, LEU25A, LEU25B, LEU43A, LEU55B, LEU61B, LEU85B, LEU9B, LYS119A, LYS156A, LYS167A, LYS187A, LYS29B, LYS50B, LYS63B, LYS88B, MET118B, MET121A, MET134A, MET1B, MET57B, MET78B, PHE130B, PHE186A, PHE19A, PHE7B, PRO129B, PRO152A, PRO152B, PRO159A, PRO21A, PRO54B, PRO80B, SER124B, SER125A, SER153A, SER20A, SER51B, SER52B, SER53B, SER58B, SER62B, SER6B, SER8B, THR10B, THR129A, THR157A, THR169A, THR179A, THR17A, THR180A, THR26B, THR2B, THR60B, TYR128A, TYR12A, TYR133A, TYR155A, TYR162A, TYR163A, TYR166A, TYR23B, TYR5B, TYR75B, TYR82B, VAL127B, VAL132B, VAL164A, VAL28A, VAL28B, VAL45A, VAL84B, VAL86B
• A-C: ALA10A, ALA132A, ARG14A, ARG4C, ARG5C, ASP13A, ASP7C, GLN27A, GLY11A, HIS15A, ILE16A, ILE18A, SER3C, SER8C, TYR12A, TYR133A, TYR6C
• A-E: ASP9E, TYR12A
• A-G: ALA112G, ALA121G, ALA132A, ALA145G, ALA162G, ALA163G, ALA171G, ALA173G, ALA31A, ALA34A, ALA90A, ALA93A, ALA94A, ARG114G, ARG135A, ARG14A, ARG168G, ARG19G, ARG91A, ARG96A, ASN11G, ASN126G, ASN20G, ASN36A, ASN92A, ASP113G, ASP13A, ASP17G, ASP180G, ASP61A, ASP65A, ASP89A, ASP8G, GLN117G, GLN120G, GLN27A, GLN37A, GLU151G, GLU174G, GLU176G, GLU24G, GLU29A, GLY116G, GLY11A, GLY138A, GLY154G, GLY158G, GLY161G, GLY18G, GLY38G, GLY4G, GLY6G, GLY85A, HIS122G, HIS146G, HIS15A, ILE16A, ILE198G, ILE39G, ILE40A, ILE72A, ILE87A, LEU124G, LEU137A, LEU147G, LEU150G, LEU175G, LEU178G, LEU63A, LEU64A, LEU95A, LEU9G, LYS160G, LYS172G, LYS177G, LYS33A, LYS40G, LYS62A, LYS98A, MET134A, MET149G, PHE14G, PHE32A, PHE73A, PRO109G, PRO136A, PRO152G, PRO159A, PRO16G, PRO60A, PRO66A, PRO86A, PRO88A, SER10G, SER127G, SER12G, SER153G, SER155G, SER15G, SER70A, THR123G, THR17A, THR35A, THR38A, THR5G, THR67A, THR68A, TRP157G, TYR125G, TYR128A, TYR12A, TYR133A, TYR148G, TYR156G, TYR159G, TYR26A, TYR30A, TYR71A, TYR7G, VAL119G, VAL139A, VAL13G, VAL179G, VAL23G, VAL28A, VAL59A, VAL69A
• A-H: ALA101A, ALA102A, ALA54H, ALA56H, ALA94A, ALA97A, ALA99A, ARG105A, ARG36H, ARG77A, ARG96A, ASP111A, ASP39H, ASP57H, CYS74A, GLN53H, GLN60H, GLN69H, GLU100A, GLU103A, GLU64H, GLY71H, HIS38H, HIS62H, ILE55H, ILE58H, ILE75A, LEU63H, LEU65H, LEU95A, LYS107A, LYS40H, LYS98A, MET112A, PHE104A, PHE73A, SER68H, SER76A, THR67H, THR72H, TYR106A, TYR110A, TYR61H, TYR66H, TYR70H, VAL59H
• A-I: ALA118A, ALA122A, ALA79I, ARG105A, ARG120A, ARG72I, ARG75I, ASN123A, ASN62I, ASP104I, ASP111A, ASP115A, ASP147A, CYS114A, GLN81I, GLN85I, GLU100A, GLU103A, GLU148A, GLU149A, GLU73I, GLY109A, GLY151A, HIS66I, ILE59I, ILE63I, LEU117A, LEU124A, LEU150A, LEU65I, LEU68I, LEU80I, LEU83I, LYS107A, LYS119A, LYS230A, LYS84I, MET112A, MET121A, MET82I, PHE104A, PHE88I, PRO105I, PRO113A, PRO74I, SER145A, SER153A, SER67I, SER71I, SER78I, THR106I, THR70I, TYR106A, TYR108A, TYR110A, TYR155A, TYR163A, TYR69I, VAL116A, VAL76I, VAL77I
• A-2: ARG105A, ASP111A, ASP231A, GLN2232, GLU148A, GLY109A, GLY2212, LYS2242, LYS230A, THR2222, THR78A, TYR106A, TYR108A, TYR110A
• B-C: ALA115B, ALA121B, ALA161B, ALA163B, ALA171B, ALA25C, ALA82C, ALA84C, ARG129C, ARG178B, ARG4B, ARG4C, ARG50C, ARG5C, ARG92C, ARG9C, ASN143B, ASN180B, ASN89C, ASP151B, ASP181B, ASP3B, ASP60C, ASP7C, ASP83C, GLN119B, GLN123B, GLN149B, GLN20B, GLN21C, GLN59C, GLU113B, GLU120B, GLU176B, GLU23C, GLU27C, GLU58C, GLU64C, GLU85C, GLY125B, GLY126B, GLY126C, GLY127C, GLY132C, GLY154B, GLY16B, GLY2C, GLY36B, GLY79C, HIS31C, ILE117B, ILE118C, ILE21B, ILE29C, ILE37B, ILE86C, ILE93C, LEU109B, LEU128C, LEU147B, LEU175B, LEU18B, LEU26C, LEU56C, LEU57C, LEU80C, LEU87C, LEU9B, LYS108B, LYS116B, LYS119C, LYS160B, LYS172B, LYS177B, LYS17B, LYS38B, LYS51C, MET118B, PHE12B, PHE131C, PHE145B, PHE157B, PHE174B, PHE7B, PRO129B, PRO130C, PRO14B, PRO152B, PRO153C, PRO158B, SER112B, SER124B, SER13B, SER146B, SER153B, SER155B, SER15B, SER28C, SER30C, SER3C, SER54C, SER62C, SER6B, SER8B, SER8C, THR107B, THR10B, THR10C, THR11B, THR122B, THR162B, THR173B, THR2B, THR53C, THR55C, THR61C, THR63C, THR81C, THR90C, TRP159B, TRP179B, TYR122C, TYR148B, TYR156B, TYR208C, TYR20C, TYR24C, TYR5B, TYR67C, TYR6C, VAL127B, VAL133C, VAL150B, VAL22C, VAL52C
• B-D: ARG4B, ARG6D, ASP3B, ASP5D, GLY125B, GLY3D, PHE7B, SER6B, SER8B, THR2B, TYR4D, TYR5B
• B-E: ALA127E, ARG4B, GLU125E, GLY124E, GLY126E, MET1B, SER128E
• B-F: ARG4B, GLN121F, GLY124F, GLY125F, MET1B, PHE7B, SER122F, THR2B, TYR123F, VAL11F
• B-G: ALA121G, ARG129G, ARG4B, ASN126G, ASP3B, HIS122G, LEU124G, MET1B, PHE7B, SER10G, SER127G, SER12G, THR2B, TYR118G, TYR125G, TYR5B, VAL128G, VAL13G
• B-I: ALA184I, ALA32I, ALA93B, ARG188I, ARG36I, ARG83B, ARG90B, ARG99B, ASN62I, ASP183I, ASP220B, ASP230B, ASP87B, CYS176I, GLN57I, GLU103B, GLU185I, GLU64I, GLU73I, GLY102B, GLY223B, GLY226B, GLY60I, HIS35I, HIS66I, HIS94B, ILE227B, ILE37I, ILE41I, ILE59I, ILE63I, LEU187I, LEU221B, LEU222B, LEU34I, LEU58I, LEU65I, LEU66B, LEU67B, LEU68I, LYS182I, LYS40I, LYS88B, LYS91B, LYS98B, MET178I, MET82I, PRO219B, PRO228B, PRO39I, PRO69B, SER38I, SER61I, SER62B, SER65B, SER67I, SER71I, SER89B, THR225B, THR229B, THR60B, THR68B, THR70I, THR95B, TRP42I, TYR101B, TYR104B, TYR186I, TYR224B, TYR69I, VAL177I, VAL84B, VAL86B, VAL92B
• B-J: ALA72J, ARG71J, ARG99B, ASN104J, ASN143B, ASP140B, GLN80J, GLU103B, GLU113B, GLU123J, GLU141B, GLU69J, GLU70J, GLU74J, GLU76J, GLU88J, GLY102B, GLY144B, HIS139B, HIS39J, ILE100B, ILE121J, ILE73J, LEU109B, LEU64J, LEU67J, LEU81J, LYS106J, LYS108B, LYS109J, LYS61J, LYS66J, LYS68J, LYS98B, PHE142B, PHE78J, PRO105B, PRO106B, PRO75J, SER105J, SER107J, SER112B, SER83J, SER84J, SER85J, SER96B, THR229B, THR62J, THR77J, THR79J, TYR101B, TYR104B, TYR148B, TYR65J, TYR97B, VAL82J
• C-D: ALA162C, ALA172C, ALA23D, ALA26D, ALA40C, ALA7D, ALA80D, ARG113C, ARG114C, ARG127D, ARG143C, ARG18C, ARG29D, ARG49D, ARG4C, ARG58D, ARG5C, ARG6D, ARG83D, ARG90D, ARG9C, ASN152C, ASN156C, ASN79D, ASP117C, ASP141C, ASP179C, ASP182C, ASP56D, ASP5D, ASP7C, ASP81D, GLN117D, GLN120C, GLN124C, GLN147C, GLN173C, GLN177C, GLN19D, GLN55D, GLU109C, GLU16C, GLU21D, GLU23C, GLU25D, GLU87D, GLY121C, GLY124D, GLY125D, GLY126C, GLY127C, GLY130D, GLY139C, GLY145C, GLY155C, GLY159C, GLY17C, GLY37C, GLY3D, GLY77D, HIS125C, ILE10D, ILE118C, ILE12C, ILE163C, ILE38C, ILE44C, ILE59D, ILE84D, LEU115C, LEU128C, LEU148C, LEU175C, LEU176C, LEU192C, LEU19C, LEU24D, LEU52D, LEU54D, LEU78D, LEU85D, LEU8D, LYS119C, LYS161C, LYS181C, LYS28D, LYS53D, LYS63D, LYS88D, MET178C, MET39C, PHE129D, PHE13C, PHE18D, PHE75D, PRO128D, PRO152D, PRO153C, PRO15C, PRO61D, SER116C, SER14C, SER151C, SER154C, SER164C, SER170C, SER3C, SER41C, SER62D, SER82D, SER8C, SER9D, THR10C, THR11C, THR121D, THR123C, THR150C, THR158C, THR169C, THR174C, THR51D, THR57D, THR60D, TRP160C, TYR120D, TYR122C, TYR144C, TYR146C, TYR149C, TYR157C, TYR180C, TYR20C, TYR22D, TYR4D, TYR6C, VAL108C, VAL112C, VAL116D, VAL126D, VAL131D, VAL20D, VAL22C, VAL27D
• C-E: ALA127E, ARG10E, ARG4C, ARG5C, ARG9C, ASP7C, ASP9E, GLU125E, GLY11E, GLY124E, GLY126E, SER13E, SER3C, THR14E, TYR6C, VAL12E
• C-F: ARG126F, ARG4C, ARG5C, ASN4F, ASN5F, ASP7C, ASP9F, GLN21F, GLY124F, GLY125F, GLY2C, GLY8F, SER122F, SER3C, THR10F, THR12F, TYR123F, TYR6C, TYR6F, VAL11F
• C-G: ARG4C, ARG5C, ASN11G, ASN126G, ASP8G, GLN22G, GLY2C, GLY6G, LEU9G, SER10G, SER127G, SER12G, SER3C, TYR125G, TYR6C, TYR7G, VAL128G, VAL13G
• C-I: ASN219I, ASP222C, ASP222I, ASP71C, CYS221I, GLN227C, GLU224C, LYS68C, TYR226C, VAL225C
• C-J: ALA74C, ALA91C, ALA95C, ARG59J, ARG92C, ASN103C, ASN55J, ASN63J, ASN70C, ASN89C, ASN97C, ASP105C, ASP71C, GLN227C, GLN96C, GLU104C, GLU56J, GLU69J, GLU70J, HIS94C, ILE229C, ILE73C, ILE88C, ILE93C, LEU54J, LEU64J, LEU66C, LEU67J, LEU69C, LEU99C, LYS100C, LYS61J, LYS66J, LYS68C, LYS68J, LYS72C, MET57J, PHE58J, SER62C, THR101C, THR52J, THR53J, THR61C, THR62J, THR63C, THR90C, TYR102C, TYR60J, TYR65J, TYR67C, TYR98C
• C-K: ALA78K, ALA88K, ARG113C, ARG143C, ARG69K, ARG84K, ASN103C, ASN62K, ASN97C, ASP105C, ASP107K, ASP117C, ASP141C, ASP142C, ASP71K, GLN77K, GLN85K, GLN96C, GLU104C, GLU109C, GLU70K, GLU73K, GLU86K, HIS94C, ILE106C, ILE110C, ILE63K, ILE68K, LEU74K, LEU99C, LYS100C, LYS109K, LYS110K, LYS124K, LYS89K, PHE82K, PRO107C, PRO76K, SER67K, SER75K, SER80K, SER81K, THR101C, TYR102C, TYR140C, TYR144C, TYR66K, TYR72K, TYR98C, VAL79K, VAL83K
• D-E: ALA114D, ALA127E, ALA161D, ALA30E, ALA54E, ALA7D, ALA83E, ALA85E, ARG10E, ARG111D, ARG119D, ARG127D, ARG132E, ARG136E, ARG172D, ARG181D, ARG6D, ARG86E, ARG93E, ASN178D, ASN215E, ASP14D, ASP180D, ASP5D, ASP62E, ASP84E, ASP9E, GLN117D, GLN118D, GLN122D, GLN149D, GLN162D, GLN19D, GLN23E, GLU107D, GLU125E, GLU144D, GLU151D, GLU173D, GLU176D, GLU21D, GLU25E, GLU29E, GLU60E, GLU65E, GLU90E, GLY115D, GLY11E, GLY124D, GLY124E, GLY125D, GLY126E, GLY139E, GLY154D, GLY15D, GLY35D, GLY80E, HIS16D, ILE10D, ILE155D, ILE17D, ILE31E, ILE64E, LEU119E, LEU133E, LEU147D, LEU175D, LEU194D, LEU28E, LEU33E, LEU58E, LEU59E, LEU81E, LEU8D, LYS146D, LYS169D, LYS177D, LYS32E, LYS37D, LYS66E, MET134E, MET88E, PHE11D, PHE123E, PHE138E, PHE174D, PHE22E, PRO128D, PRO137E, PRO13D, PRO145D, PRO152D, PRO160E, PRO57E, SER123D, SER12D, SER135E, SER153D, SER157D, SER158D, SER160D, SER27E, SER56E, SER61E, SER63E, SER87E, SER9D, THR121D, THR163D, THR55E, THR82E, TRP159D, TYR120D, TYR148D, TYR156D, TYR179D, TYR26E, TYR4D, VAL126D, VAL12E, VAL140E, VAL171D, VAL20D, VAL24E, VAL34D, VAL36D
• D-F: ARG6D, ASP5D, TYR123F
• D-K: ALA56K, ALA61K, ALA89D, ALA93D, ARG35K, ARG69K, ARG83D, ARG90D, ARG97D, ASN62K, ASP68D, ASP71K, GLN54K, GLN60K, GLN64K, GLN94D, GLU101D, GLU57K, GLU70K, GLU87D, GLU92D, HIS70D, ILE59K, ILE63K, ILE67D, ILE68K, ILE86D, LEU65K, LEU98D, LYS66D, LYS88D, PHE55K, SER62D, SER65D, SER67K, SER69D, SER95D, THR99D, TYR58K, TYR66K, VAL53K, VAL71D, VAL91D
• D-L: ALA77L, ALA78L, ALA79L, ARG111D, ARG121L, ARG141D, ARG69L, ARG97D, ASN85L, ASP102D, ASP139D, GLU101D, GLU107D, GLU108L, GLU70L, GLU72L, HIS66L, HIS96D, ILE74L, ILE82L, LEU100D, LEU68L, LEU98D, LYS107L, LYS123L, LYS71L, LYS81L, SER75L, SER80L, THR105D, THR99D, TYR108D, TYR113L, TYR148D, TYR156D, VAL104D, VAL76L
• E-F: ALA120E, ALA127E, ALA169E, ALA171E, ALA181E, ALA25F, ALA28F, ALA41E, ALA53F, ALA78F, ALA81F, ARG10E, ARG122E, ARG126F, ARG132E, ARG166E, ARG20E, ARG3F, ARG51F, ARG82F, ARG89F, ASN119F, ASN168E, ASN185E, ASN4F, ASN52F, ASN86F, ASP118E, ASP54F, ASP7F, ASP80F, ASP9E, ASP9F, CYS117E, GLN114E, GLN117F, GLN121F, GLN180E, GLN21F, GLN31F, GLN60F, GLN90F, GLU110E, GLU125E, GLU130E, GLU159E, GLU177E, GLU182E, GLU186E, GLU18E, GLU23F, GLU25E, GLU27F, GLU55F, GLY11E, GLY124E, GLY124F, GLY125F, GLY126E, GLY129E, GLY129F, GLY162E, GLY19E, GLY39E, GLY76F, GLY8F, HIS157E, HIS188E, ILE29F, ILE40E, ILE64F, LEU121E, LEU155E, LEU183E, LEU184E, LEU191E, LEU21E, LEU26F, LEU56F, LEU74F, LEU77F, LYS115F, LYS118F, LYS170E, LYS30F, LYS50F, LYS61F, PHE123E, PHE156E, PHE15E, PHE164E, PHE20F, PHE22E, PRO127F, PRO149F, PRO160E, PRO17E, PRO79F, SER111E, SER115E, SER122F, SER128E, SER13E, SER161E, SER16E, SER57F, SER58F, THR10F, THR120F, THR14E, THR163E, TRP187E, TYR123F, TYR128F, TYR165E, TYR167E, TYR24F, TYR59F, VAL12E, VAL130F, VAL22F, VAL24E, VAL83F
• E-G: SER127G, SER128E
• E-L: ALA92E, ALA95E, ALA96E, ARG64L, ARG69L, ARG72E, ARG86E, ARG93E, ASN100E, ASP104E, ASP62E, ASP71E, CYS63L, GLN53L, GLN62L, GLU56L, GLU65E, GLU67L, GLU69E, GLU70L, GLU90E, GLY227E, GLY60L, GLY75E, HIS66L, HIS73E, HIS91E, HIS99E, ILE230E, ILE67E, ILE70E, ILE74E, ILE89E, LEU101E, LEU59L, LEU65L, LEU68L, LYS71L, PHE228E, PHE54L, SER61L, SER63E, THR57L, THR94E, THR98E, TRP55L, TRP58L, TYR102E, VAL68E, VAL97E
• E-M: ALA149E, ALA80M, ALA81M, ALA95E, ARG82M, ASN100E, ASN108E, ASN71M, ASN78M, ASN83M, ASP104E, ASP106E, ASP148E, ASP150E, ASP151E, ASP69M, GLN114E, GLN154E, GLN85M, GLU105E, GLU107M, GLU110E, HIS70M, HIS86M, HIS99E, ILE107E, ILE77M, ILE84M, LEU101E, LEU112E, LEU75M, LEU87M, LYS73M, LYS74M, PHE59M, PHE68M, SER111E, SER115E, SER62M, SER76M, SER79M, THR98E, TRP65M, TYR102E, TYR103E, TYR114M, TYR122M, TYR66M, VAL109E, VAL63M, VAL97E
• F-G: ALA116F, ALA142F, ALA160F, ALA168F, ALA26G, ALA29G, ARG107F, ARG129G, ARG174F, ARG18F, ARG39F, ARG3F, ARG85G, ARG92G, ASN119F, ASN11G, ASN126G, ASN152F, ASN32G, ASN4F, ASN5F, ASN63G, ASN89G, ASP114F, ASP177F, ASP7F, ASP83G, ASP8G, ASP9F, CYS113F, GLN117F, GLN121F, GLN148F, GLN166F, GLN22G, GLN67G, GLU106F, GLU146F, GLU155F, GLU173F, GLU24G, GLU31G, GLU93G, GLY109F, GLY124F, GLY125F, GLY132G, GLY151F, GLY158F, GLY17F, GLY37F, GLY6G, GLY79G, GLY84G, GLY8F, HIS110F, HIS122G, HIS143F, HIS86G, ILE180F, ILE53G, ILE81G, LEU111F, LEU112F, LEU144F, LEU145F, LEU156F, LEU172F, LEU176F, LEU19F, LEU38F, LEU52G, LEU57G, LEU58G, LEU80G, LEU87G, LEU9G, LYS115F, LYS118F, LYS169F, LYS28G, LYS51G, LYS56G, LYS62G, LYS65G, PHE131G, PHE13F, PHE179F, PHE21G, PHE2F, PRO130G, PRO149F, PRO152G, PRO15F, PRO60G, PRO82G, SER10G, SER122F, SER127G, SER140F, SER14F, SER150F, SER55G, THR10F, THR120F, THR12F, THR154F, THR159F, THR16F, THR170F, THR175F, THR54G, THR5G, TYR118G, TYR123F, TYR125G, TYR157F, TYR171F, TYR25G, TYR6F, TYR7G, VAL119G, VAL11F, VAL128G, VAL133G, VAL153F, VAL22F, VAL23G, VAL27G, VAL30G, VAL36F, VAL59G, VAL64G
• F-M: ARG58M, ARG82F, ARG89F, ASN100F, ASN61M, ASN71M, ASN86F, ASN93F, ASP226F, ASP67F, ASP69M, ASP72M, CYS66F, CYS92F, GLN90F, GLN91F, GLU68F, HIS67M, HIS69F, HIS70M, ILE224F, ILE64F, LEU88F, LEU97F, LYS102F, LYS57M, LYS60M, LYS61F, LYS64M, LYS65F, MET70F, PHE222F, PHE68M, PHE99F, SER62M, SER85F, SER96F, THR223F, TRP65M, TYR87F, TYR94F, VAL98F
• F-N: ALA104F, ALA67N, ALA73N, ALA75N, ALA78N, ALA89N, ARG101F, ARG107F, ASN100F, ASN114N, ASN66N, ASN70N, ASP114F, ASP138F, ASP69N, GLN112N, GLN94N, GLU106F, GLU155F, GLU65N, GLU76N, GLU77N, GLU80N, GLU86N, GLY141F, HIS110F, HIS143F, ILE84N, LEU103F, LEU62N, LEU72N, LEU79N, LEU88N, LEU97F, LYS102F, LYS139F, PHE118N, PHE85N, PHE99F, PRO71N, PRO81N, SER113N, SER140F, SER82N, SER95F, SER96F, THR90N, TYR68N, TYR83N, TYR87N, TYR94F, VAL105F, VAL91N, VAL98F
• G-H: ALA110G, ALA78H, ALA79H, ARG114G, ASN106H, ASN143G, ASP103H, ASP113G, GLN117G, GLN69H, GLU76H, GLU84H, GLU88H, GLU94G, GLY71H, HIS62H, ILE106G, ILE58H, LEU101G, LEU63H, LEU65H, LEU85H, LYS100G, LYS103G, LYS105H, LYS142G, LYS83H, LYS99G, PHE111G, PHE82H, PHE98G, PRO105G, PRO107G, PRO109G, PRO73H, SER74H, SER80H, THR104G, THR67H, THR72H, THR77H, TYR102G, TYR111H, TYR61H, TYR66H, TYR70H, TYR87H, VAL119H, VAL59H, VAL81H
• G-N: ALA67N, ALA73N, ALA75N, ALA95G, ALA96G, ARG57N, ARG71G, ARG85G, ARG92G, ASN63G, ASN66N, ASN70N, ASN89G, ASP61N, ASP69N, ASP70G, ASP74N, GLN53N, GLN61G, GLN67G, GLU56N, GLU65N, GLU93G, GLY38N, GLY91G, HIS227G, HIS54N, HIS72G, ILE66G, ILE73G, LEU101G, LEU58N, LEU59N, LEU62N, LEU72N, LYS100G, LYS103G, LYS228G, LYS231G, LYS60N, LYS62G, LYS65G, LYS99G, PHE229G, PRO71N, SER97G, THR64N, TYR68N, TYR77G, VAL63N, VAL64G, VAL68G, VAL69G, VAL88G
• H-I: ALA115I, ALA133I, ALA134I, ALA136I, ALA24H, ALA27H, ALA49H, ALA50H, ALA54H, ALA56H, ARG174H, ARG29H, ARG45H, ASN28H, ASN89H, ASN92H, ASP120I, ASP32H, ASP51H, ASP57H, GLN53H, GLN60H, GLN81I, GLN85I, GLN91I, GLU-5H, GLU139I, GLY-6H, GLY117I, GLY122I, GLY128I, GLY92I, HIS114I, HIS116I, HIS93I, ILE113I, ILE26H, ILE55H, ILE58H, LEU-2H, LEU125I, LEU127I, LEU132I, LEU138I, LEU80I, LEU87I, LEU93H, LYS-7H, LYS-8H, LYS84I, MET135I, PHE88I, SER-3H, SER112I, SER118I, SER126I, SER131I, SER48H, THR119I, THR20H, THR22H, THR31H, THR52H, THR94H, TRP142I, TYR123I, TYR124I, TYR25H, TYR61H, TYR90I, TYR97I, VAL-4H, VAL121I, VAL30H
• H-N: ALA125H, ALA127H, ARG27N, ARG57N, ARG95N, ASN100N, ASN29N, ASP48N, ASP51N, ASP91H, CYS86H, GLN-6N, GLN-7N, GLN53N, GLU56N, GLU84H, GLU88H, GLY116H, GLY117H, GLY128H, GLY20N, GLY30N, GLY96H, HIS120H, HIS54N, ILE-4N, ILE113H, ILE126H, ILE3H, ILE49N, ILE55N, ILE97H, ILE98H, LEU-9H, LEU102N, LEU115H, LEU122H, LEU25N, LEU26N, LEU58N, LYS121H, LYS83H, LYS90H, MET52N, PHE28N, PRO-5N, PRO101N, PRO114H, SER118H, SER131H, SER46H, SER50N, SER80H, THR-2N, THR-8N, THR112H, THR132H, THR94H, TRP103N, TYR124H, TYR135H, TYR22N, TYR87H, VAL-3N, VAL119H, VAL31N
• H-V: ALA162H, ALA162V, ASN141H, ASN141V, ASP139H, ASP139V, ASP153H, ASP153V, CYS138H, CYS138V, GLN161H, GLN161V, GLN195H, GLN195V, GLU194H, GLU194V, GLY136H, GLY136V, HIS157H, HIS157V, ILE126H, ILE126V, ILE134H, ILE134V, LEU122H, LEU122V, LEU196H, LEU196V, LYS140H, LYS140V, LYS156H, LYS156V, LYS164H, LYS164V, PHE133H, PHE133V, SER131H, SER131V, SER158H, SER158V, SER160H, SER160V, THR132H, THR132V, TRP165H, TRP165V, TYR124H, TYR124V, TYR135H, TYR135V, TYR137H, TYR137V, TYR193H, TYR193V
• H-2: ALA162H, ALA1812, ALA2142, ALA24H, ALA27H, ALA49H, ALA54H, ALA56H, ARG1742, ARG174H, ARG1792, ARG1822, ARG1852, ARG185H, ARG19H, ARG272, ARG29H, ARG36H, ARG45H, ASN1862, ASN2082, ASN28H, ASN292, ASP166H, ASP1802, ASP191H, ASP2122, ASP2162, ASP32H, ASP39H, ASP57H, CYS43H, GLN161H, GLN195H, GLN2052, GLN2232, GLN53H, GLN60H, GLU192H, GLU194H, GLU2072, GLY-1H, GLY130H, GLY167H, GLY170H, GLY171H, GLY202, GLY2192, GLY2212, GLY232, GLY23H, HIS1412, HIS38H, ILE163H, ILE187H, ILE2172, ILE2252, ILE26H, ILE55H, ILE58H, LEU-2H, LEU1762, LEU178H, LEU186H, LEU192, LEU252, LEU262, LEU34H, LYS164H, LYS2102, LYS2152, LYS2182, LYS2242, LYS33H, LYS40H, MET1422, MET2092, PHE133H, PHE1382, PHE188H, PHE2132, PHE282, PRO190H, SER129H, SER168H, SER169H, SER1832, SER18H, SER212, SER242, THR12, THR132H, THR20H, THR21H, THR2222, THR22H, THR31H, THR35H, THR52H, TRP165H, TRP2112, TRP42H, TYR1772, TYR1782, TYR189H, TYR193H, TYR2202, TYR222, TYR25H, VAL172H, VAL1752, VAL176H, VAL183H, VAL2062, VAL30H, VAL37H
• I-J: ALA124J, ALA161J, ALA176J, ALA211I, ALA27I, ALA32I, ALA49I, ALA50I, ALA54I, ALA72J, ALA96I, ARG188I, ARG189J, ARG196I, ARG207I, ARG90J, ASN148J, ASN164J, ASN189I, ASN219I, ASN30I, ASP116J, ASP122J, ASP126J, ASP135J, ASP153J, ASP184J, ASP222I, ASP28I, ASP51I, CYS120J, CYS141J, CYS221I, CYS31I, GLN136J, GLN160J, GLN195J, GLN22I, GLN57I, GLN80J, GLU123J, GLU142J, GLU146J, GLU150J, GLU152J, GLU156J, GLU185J, GLU215I, GLU32J, GLU53I, GLY119J, GLY131J, GLY139J, GLY175J, GLY208I, GLY38J, GLY92I, GLY95I, HIS36J, HIS39J, HIS86I, HIS93I, ILE118J, ILE121J, ILE128J, ILE158J, ILE180J, ILE181J, ILE217I, ILE220I, ILE25I, ILE34J, ILE94I, LEU117J, LEU144J, LEU149J, LEU154J, LEU162J, LEU163J, LEU18J, LEU191J, LEU213I, LEU58I, LEU86J, LEU87I, LYS125J, LYS182J, LYS183J, LYS188J, LYS192J, LYS199I, LYS201I, LYS204I, LYS214I, LYS29I, LYS30J, LYS66J, MET140J, MET193J, MET6J, PHE115J, PHE127J, PHE138J, PHE155J, PHE205I, PHE41J, PHE91J, PRO147J, PRO151J, PRO206I, PRO24I, SER105J, SER130J, SER134J, SER143J, SER159J, SER202I, SER20I, SER216I, SER83J, SER84J, THR157J, THR209I, THR210I, THR48I, THR52I, TYR145J, TYR179J, TYR190J, TYR203I, TYR37J, TYR87J, TYR90I, VAL129J, VAL177J, VAL178J, VAL186J, VAL187J, VAL212I, VAL218I, VAL26I, VAL40J, VAL55I
• I-Z: GLY212Z, ILE211Z, LEU213I, LYS201Z, LYS214I, TRP198Z, VAL210Z
• I-1: ALA1321, ALA1331, ALA133I, ALA161I, ALA1821, ALA211I, ALA27I, ARG1761, ARG1851, ARG191, ARG196I, ARG19I, ARG207I, ARG2121, ARG291, ASN1431, ASN1491, ASN1561, ASN165I, ASN172I, ASN194I, ASN201, ASN271, ASN30I, ASP166I, ASP1771, ASP17I, ASP1911, ASP2131, ASP231, ASP28I, GLN1441, GLN1501, GLN160I, GLN1881, GLN200I, GLN22I, GLU1521, GLU1691, GLU1701, GLU1841, GLU197I, GLU198I, GLU2091, GLY-11, GLY11, GLY130I, GLY1541, GLY1571, GLY162I, GLY168I, GLY170I, GLY1901, GLY208I, GLY23I, HIS1861, ILE163I, ILE1721, ILE1871, ILE211, ILE25I, ILE261, LEU132I, LEU1361, LEU1411, LEU1661, LEU167I, LEU1741, LEU1931, LEU2101, LEU213I, LYS1481, LYS1581, LYS1601, LYS1611, LYS1731, LYS199I, LYS201I, LYS204I, LYS2111, LYS214I, LYS29I, PHE1401, PHE1471, PHE1791, PHE205I, PRO1531, PRO193I, PRO206I, PRO24I, SER129I, SER1351, SER169I, SER171I, SER1781, SER1811, SER202I, SER20I, SER251, THR1551, THR1801, THR1831, THR18I, THR1I, THR209I, THR210I, THR21I, THR221, TRP164I, TYR1511, TYR203I, TYR2081, TYR241, VAL1591, VAL1751, VAL1891, VAL195I, VAL212I, VAL26I
• I-2: ALA133I, ALA134I, ALA136I, ALA1402, ALA1432, ALA158I, ALA161I, ALA1722, ALA2142, ARG1482, ARG1742, ARG1792, ARG75I, ASN1442, ASN165I, ASN1712, ASP120I, ASP1522, ASP157I, ASP166I, ASP1802, ASP2122, ASP2162, GLN144I, GLN160I, GLN2232, GLN81I, GLN85I, GLU139I, GLY117I, GLY122I, GLY130I, GLY1372, GLY1392, GLY162I, GLY2192, GLY2212, HIS109I, HIS114I, HIS1412, HIS141I, ILE113I, ILE2172, LEU110I, LEU125I, LEU127I, LEU132I, LEU138I, LEU1462, LEU1472, LEU154I, LEU167I, LEU1762, LEU80I, LYS143I, LYS1492, LYS153I, LYS2102, LYS2152, LYS2182, LYS2242, LYS7I, LYS84I, MET135I, MET1422, PHE111I, PHE1382, PHE2132, PRO1452, SER112I, SER118I, SER126I, SER129I, SER131I, SER140I, SER78I, THR106I, THR119I, THR1332, THR2222, TRP142I, TRP164I, TRP2112, TYR123I, TYR124I, TYR1782, TYR2202, VAL121I, VAL137I, VAL1752, VAL76I, VAL77I
• J-K: ALA131K, ALA48J, ALA88K, ARG59J, ARG7K, ARG84K, ARG89J, ARG92K, ASN-2J, ASN29J, ASN55J, ASP119K, ASP144K, ASP50J, GLN117K, GLN23J, GLN85K, GLU126K, GLU32J, GLU56J, GLY122K, GLY130K, GLY133K, GLY136K, GLY21J, GLY26J, GLY92J, HIS132K, ILE-3J, ILE118K, ILE91K, LEU117J, LEU121K, LEU127K, LEU20J, LEU25J, LEU47J, LEU54J, LEU87K, LYS124K, LYS30J, LYS89K, MET57J, PHE137K, PHE140K, PHE31J, PHE91J, PHE95J, PRO-6J, PRO128K, PRO93J, SER-8J, SER135K, SER141K, SER22J, SER24J, SER28J, SER81K, THR123K, THR139K, THR49J, THR52J, THR53J, TRP174J, TYR120K, TYR129K, TYR134K, TYR138K, TYR60J, TYR94J, VAL125K, VAL27J, VAL51J, VAL96J
• J-Z: ALA133J, ALA163Z, ALA164Z, ALA165J, ALA165Z, ALA166J, ALA169Z, ALA170J, ALA20Z, ALA22Z, ALA27Z, ARG167Z, ARG168J, ARG194J, ARG19J, ARG19Z, ASN164J, ASN208Z, ASN209Z, ASN24Z, ASN29J, ASP-7J, ASP135J, ASP167J, ASP168Z, ASP169J, ASP17Z, ASP192Z, ASP196J, GLN136J, GLN195J, GLN23J, GLN29Z, GLU195Z, GLU202Z, GLY-1J, GLY132Z, GLY172Z, GLY173Z, GLY175J, GLY194Z, GLY1J, GLY212Z, GLY21J, GLY23Z, GLY26J, HIS166Z, HIS191Z, ILE-3J, ILE211Z, LEU162Z, LEU171J, LEU18J, LEU191J, LEU196Z, LEU20J, LEU25J, LYS192J, LYS199Z, LYS201Z, LYS30J, MET193J, PHE135Z, PHE197Z, PHE207Z, SER-4J, SER-5J, SER131Z, SER171Z, SER172J, SER174Z, SER18Z, SER22J, SER24J, SER28J, SER28Z, THR132J, THR134Z, THR21Z, THR30Z, TRP174J, TRP198Z, TRP25Z, TYR170Z, TYR190J, VAL175Z, VAL193Z, VAL210Z, VAL26Z, VAL27J, VAL31Z
• J-1: ALA124J, ALA1291, ALA1321, ALA1331, ALA133J, ALA1341, ALA161J, ALA165J, ALA166J, ALA1821, ARG1281, ARG168J, ARG1851, ARG194J, ASN1431, ASN1461, ASN1491, ASN1561, ASN164J, ASP122J, ASP126J, ASP135J, ASP1421, ASP167J, ASP169J, ASP1771, CYS1271, CYS141J, GLN136J, GLN1441, GLN1501, GLN160J, GLU142J, GLU156J, GLU1841, GLY139J, GLY1571, HIS1861, ILE128J, ILE1371, LEU1361, LEU137J, LEU1411, LEU144J, LEU162J, LEU163J, LEU1741, LEU191J, LYS125J, LYS1481, LYS1581, LYS1601, LYS192J, MET1381, MET140J, MET193J, PHE127J, PHE138J, PHE1401, PHE1471, PHE1791, PRO1391, PRO1531, SER134J, SER1351, SER143J, SER159J, SER1781, SER1811, THR1801, THR1831, TYR1511, VAL129J
• K-L: ALA19K, ALA49K, ALA93L, ARG121L, ARG22K, ARG35K, ARG94K, ARG95K, ASN85L, ASP116L, ASP118L, ASP125L, ASP29K, ASP31K, ASP32K, ASP51K, CYS128L, GLN133L, GLN54K, GLN60K, GLN89L, GLN98K, GLU48K, GLU57K, GLY119L, GLY124L, GLY130L, GLY23K, GLY50K, GLY92L, GLY98L, ILE126L, ILE24K, LEU122L, LEU27K, LEU86L, LYS123L, LYS28K, LYS33K, LYS81L, LYS91L, MET100L, PHE127L, PHE135L, PHE55K, PRO96K, SER117L, SER131L, SER25K, SER30K, SER84L, THR120L, THR134L, THR21K, THR52K, TYR113L, TYR114L, TYR137L, TYR58K, TYR88L, TYR90L, TYR97K, VAL115L, VAL129L, VAL20K, VAL26K, VAL53K, VAL87L, VAL99K
• K-Y: ALA19K, ALA19Y, ARG170K, ARG170Y, ARG22K, ARG22Y, ASP174K, ASP174Y, ASP29K, ASP29Y, GLN165K, GLN165Y, GLU166K, GLU166Y, GLU168K, GLU168Y, GLY133K, GLY133Y, GLY136K, GLY136Y, GLY23K, GLY23Y, ILE24K, ILE24Y, LEU167K, LEU167Y, LEU27K, LEU27Y, LYS169K, LYS169Y, LYS176K, LYS176Y, LYS28K, LYS28Y, MET171K, MET171Y, MET173K, MET173Y, PHE137K, PHE137Y, PHE175K, PHE175Y, PRO172K, PRO172Y, SER135K, SER135Y, SER25K, SER25Y, THR21K, THR21Y, TYR134K, TYR134Y, TYR138K, TYR138Y, VAL20K, VAL20Y, VAL26K, VAL26Y
• K-Z: ALA131K, ALA136Z, ALA163Z, ALA164Z, ALA169Z, ARG148K, ARG159Z, ARG167Z, ARG170K, ARG7K, ASN143Z, ASN208Z, ASN209Z, ASP125Z, ASP141Z, ASP144K, ASP150K, ASP168Z, CYS128Z, CYS163K, GLN117K, GLN133Z, GLN165K, GLU126K, GLU166K, GLU202Z, GLU203Z, GLU204Z, GLY130K, GLY132Z, GLY136K, GLY138Z, GLY205Z, HIS145K, HIS146K, HIS166Z, ILE126Z, LEU127K, LEU140Z, LEU142K, LEU143K, LEU156Z, LEU162K, LEU162Z, LEU167K, LYS169K, LYS201Z, MET171K, PHE127Z, PHE135Z, PHE137K, PHE140K, PHE197Z, PHE207Z, PHE6Z, PRO128K, PRO149K, PRO172K, SER131Z, SER135K, SER141K, SER142Z, SER160Z, SER206Z, THR134Z, THR139K, TYR129K, TYR134K, TYR137Z, TYR138K, TYR144Z, TYR147K, TYR155Z, TYR170Z, VAL125K, VAL139Z, VAL200Z, VAL210Z
• L-M: ALA129M, ALA133M, ALA134M, ALA20L, ALA22L, ALA27L, ALA49L, ALA50L, ALA93L, ARG124M, ARG128M, ARG33L, ARG82M, ARG92M, ASN146M, ASN149M, ASN83M, ASP117M, ASP142M, ASP192L, ASP51L, CYS127M, CYS52L, GLN126M, GLN29L, GLN53L, GLN85M, GLU123M, GLU125M, GLU195L, GLU202L, GLU36L, GLU56L, GLY120M, GLY130M, GLY157M, GLY173L, GLY194L, GLY212L, GLY48L, GLY90M, GLY92L, GLY94L, HIS86M, HIS99M, ILE137M, ILE35L, LEU136M, LEU86L, LEU87M, LEU88M, LEU95L, LYS148M, LYS158M, LYS160M, LYS32L, MET138M, MET45L, MET97L, PHE116M, PHE140M, PHE54L, PHE93M, PRO118M, PRO139M, SER115M, SER117L, SER121M, SER135M, SER18L, SER28L, SER61L, SER96L, THR30L, THR57L, TRP198L, TRP25L, TRP55L, TRP58L, TYR122M, TYR151M, TYR89M, TYR90L, VAL119M, VAL26L, VAL31L, VAL34L
• L-W: GLY212L, ILE211L, LEU213W, LYS201L, LYS214W, TRP198L, VAL210L
• L-X: ALA133X, ALA163L, ALA164L, ALA165L, ALA165X, ALA166X, ALA169L, ALA170X, ALA20L, ALA22L, ALA27L, ARG167L, ARG168X, ARG194X, ARG19L, ARG19X, ASN164X, ASN208L, ASN209L, ASN24L, ASN29X, ASP-7X, ASP135X, ASP167X, ASP168L, ASP169X, ASP17L, ASP192L, ASP196X, GLN136X, GLN195X, GLN23X, GLN29L, GLU195L, GLU202L, GLY-1X, GLY132L, GLY172L, GLY173L, GLY175X, GLY194L, GLY1X, GLY212L, GLY21X, GLY23L, GLY26X, HIS166L, HIS191L, ILE-3X, ILE161L, ILE211L, LEU162L, LEU171X, LEU18X, LEU191X, LEU196L, LEU20X, LEU25X, LYS192X, LYS199L, LYS201L, LYS30X, MET193X, PHE135L, PHE197L, PHE207L, SER-4X, SER-5X, SER131L, SER171L, SER172X, SER174L, SER18L, SER22X, SER24X, SER28L, SER28X, THR132X, THR134L, THR21L, THR30L, TRP174X, TRP198L, TRP25L, TYR170L, TYR190X, VAL175L, VAL193L, VAL210L, VAL26L, VAL27X, VAL31L
• L-Y: ALA131Y, ALA136L, ALA163L, ALA164L, ALA169L, ARG148Y, ARG159L, ARG167L, ARG170Y, ARG7Y, ASN143L, ASN208L, ASN209L, ASP125L, ASP141L, ASP144Y, ASP150Y, ASP168L, CYS128L, CYS163Y, GLN117Y, GLN133L, GLN165Y, GLU126Y, GLU166Y, GLU202L, GLU203L, GLU204L, GLY130Y, GLY132L, GLY136Y, GLY138L, GLY205L, HIS145Y, HIS146Y, HIS166L, ILE126L, LEU127Y, LEU140L, LEU142Y, LEU143Y, LEU156L, LEU162L, LEU162Y, LEU167Y, LYS169Y, LYS201L, MET171Y, PHE127L, PHE135L, PHE137Y, PHE140Y, PHE197L, PHE207L, PHE6L, PRO128Y, PRO149Y, PRO172Y, SER131L, SER135Y, SER141Y, SER142L, SER160L, SER206L, THR134L, THR139Y, TYR129Y, TYR134Y, TYR137L, TYR138Y, TYR144L, TYR147Y, TYR155L, TYR170L, VAL125Y, VAL139L, VAL200L, VAL210L
• M-N: ALA135N, ALA140N, ALA49M, ALA50M, ALA54M, ALA89N, ARG120N, ARG148N, ARG153N, ARG212M, ARG29M, ARG58M, ARG95N, ARG96N, ASN-2M, ASN-7M, ASN100N, ASN104N, ASN123N, ASN144N, ASN20M, ASN27M, ASP-3M, ASP152N, ASP156N, ASP191M, ASP23M, ASP51M, ASP53M, GLN-6N, GLN-7N, GLN-9M, GLN94N, GLU154N, GLU209M, GLU31M, GLU86N, GLY-4M, GLY126N, GLY137N, GLY52M, HIS141N, ILE21M, ILE26M, LEU102N, LEU124N, LEU125N, LEU134N, LEU210M, LEU55M, LYS57M, LYS91M, LYS98N, MET92N, MET99N, PHE-8M, PHE207M, PHE35M, PHE48M, PHE85N, PHE94M, PRO-5N, PRO-6M, PRO101N, PRO132N, PRO145N, PRO32M, PRO95M, SER130N, SER131N, SER25M, SER28M, SER97N, THR-8N, THR128N, THR133N, THR22M, THR90N, TRP103N, TYR-5M, TYR121N, TYR129N, TYR24M, TYR30M, TYR87N, TYR93N, TYR96M, TYR97M, VAL122N, VAL127N, VAL151N, VAL98M
• M-W: ALA132M, ALA133M, ALA133W, ALA161W, ALA182M, ALA211W, ALA27W, ARG176M, ARG185M, ARG196W, ARG19M, ARG19W, ARG207W, ARG212M, ARG29M, ASN143M, ASN149M, ASN156M, ASN165W, ASN172W, ASN194W, ASN20M, ASN27M, ASN30W, ASP166W, ASP177M, ASP17W, ASP191M, ASP213M, ASP23M, ASP28W, GLN144M, GLN150M, GLN160W, GLN188M, GLN200W, GLN22W, GLU152M, GLU169M, GLU170M, GLU184M, GLU197W, GLU198W, GLU209M, GLY-1M, GLY130W, GLY154M, GLY157M, GLY162W, GLY168W, GLY170W, GLY190M, GLY208W, GLY23W, HIS186M, ILE163W, ILE172M, ILE187M, ILE21M, ILE25W, ILE26M, LEU132W, LEU136M, LEU141M, LEU166M, LEU167W, LEU174M, LEU210M, LEU213W, LYS148M, LYS158M, LYS160M, LYS161M, LYS173M, LYS199W, LYS201W, LYS204W, LYS211M, LYS29W, PHE140M, PHE147M, PHE179M, PHE205W, PRO153M, PRO193W, PRO206W, PRO24W, SER129W, SER135M, SER169W, SER171W, SER178M, SER181M, SER202W, SER20W, SER25M, THR155M, THR180M, THR183M, THR18W, THR1W, THR209W, THR210W, THR21W, THR22M, TRP164W, TYR151M, TYR203W, TYR208M, TYR24M, VAL145M, VAL159M, VAL171M, VAL175M, VAL189M, VAL195W, VAL212W, VAL26W
• M-X: ALA124X, ALA129M, ALA132M, ALA133M, ALA133X, ALA134M, ALA161X, ALA165X, ALA166X, ALA182M, ARG128M, ARG168X, ARG185M, ARG194X, ASN143M, ASN146M, ASN149M, ASN156M, ASN164X, ASP122X, ASP126X, ASP135X, ASP142M, ASP167X, ASP169X, ASP177M, CYS127M, CYS141X, GLN136X, GLN144M, GLN150M, GLN160X, GLU142X, GLU156X, GLU184M, GLY139X, GLY157M, HIS186M, ILE128X, ILE137M, LEU136M, LEU137X, LEU141M, LEU144X, LEU162X, LEU163X, LEU174M, LEU191X, LYS125X, LYS148M, LYS158M, LYS160M, LYS192X, MET138M, MET140X, MET193X, PHE127X, PHE138X, PHE140M, PHE147M, PHE179M, PRO139M, PRO153M, SER134X, SER135M, SER143X, SER159X, SER178M, SER181M, THR180M, THR183M, TYR145X, TYR151M, VAL129X
• N-O: ARG105O, ASP111O, ASP231O, GLN223N, GLU148O, GLY109O, GLY221N, LYS224N, LYS230O, THR222N, THR78O, TYR106O, TYR108O, TYR110O
• N-V: ALA162V, ALA181N, ALA214N, ALA24V, ALA27V, ALA49V, ALA54V, ALA56V, ARG174N, ARG174V, ARG179N, ARG182N, ARG185N, ARG185V, ARG19V, ARG27N, ARG29V, ARG36V, ARG45V, ASN186N, ASN208N, ASN28V, ASN29N, ASP166V, ASP180N, ASP191V, ASP212N, ASP216N, ASP32V, ASP39V, ASP57V, CYS43V, GLN195V, GLN205N, GLN223N, GLN53V, GLN60V, GLU192V, GLU194V, GLU207N, GLY130V, GLY167V, GLY170V, GLY171V, GLY20N, GLY219N, GLY221N, GLY23N, GLY23V, HIS141N, HIS38V, ILE163V, ILE187V, ILE217N, ILE225N, ILE26V, ILE55V, ILE58V, LEU-2V, LEU176N, LEU178V, LEU186V, LEU19N, LEU25N, LEU26N, LEU34V, LYS164V, LYS210N, LYS215N, LYS218N, LYS224N, LYS33V, LYS40V, MET142N, MET209N, PHE133V, PHE138N, PHE188V, PHE213N, PHE28N, PRO190V, SER129V, SER168V, SER169V, SER183N, SER184N, SER18V, SER21N, SER24N, THR132V, THR1N, THR20V, THR21V, THR222N, THR22V, THR31V, THR35V, THR52V, TRP165V, TRP211N, TRP42V, TYR177N, TYR178N, TYR189V, TYR193V, TYR220N, TYR22N, TYR25V, VAL172V, VAL175N, VAL176V, VAL183V, VAL206N, VAL30V, VAL37V
• N-W: ALA133W, ALA134W, ALA136W, ALA140N, ALA143N, ALA158W, ALA161W, ALA172N, ALA214N, ARG148N, ARG174N, ARG179N, ARG75W, ASN144N, ASN165W, ASN171N, ASP120W, ASP152N, ASP157W, ASP166W, ASP180N, ASP212N, ASP216N, GLN144W, GLN160W, GLN223N, GLN81W, GLN85W, GLU139W, GLY117W, GLY122W, GLY130W, GLY137N, GLY139N, GLY162W, GLY219N, GLY221N, HIS109W, HIS114W, HIS141N, HIS141W, ILE113W, ILE217N, LEU110W, LEU125W, LEU127W, LEU132W, LEU138W, LEU146N, LEU147N, LEU154W, LEU167W, LEU176N, LEU80W, LYS143W, LYS149N, LYS153W, LYS210N, LYS215N, LYS218N, LYS224N, LYS7W, LYS84W, MET135W, MET142N, PHE111W, PHE138N, PHE213N, PRO145N, SER112W, SER118W, SER126W, SER129W, SER131W, SER140W, SER78W, THR106W, THR119W, THR133N, THR222N, TRP142W, TRP164W, TRP211N, TYR123W, TYR124W, TYR178N, TYR220N, VAL121W, VAL137W, VAL175N, VAL76W, VAL77W
• O-P: ALA10O, ALA118O, ALA121P, ALA122O, ALA132O, ALA160O, ALA168O, ALA170O, ALA24P, ALA27P, ALA44O, ALA56P, ARG120O, ARG128P, ARG131O, ARG24O, ARG46O, ARG4P, ARG83P, ARG90P, ASN123O, ASN181O, ASN184O, ASP115O, ASP13O, ASP158O, ASP192O, ASP207P, ASP22P, ASP3P, ASP81P, ASP87P, GLN126O, GLN130O, GLN175O, GLN176O, GLN20P, GLN30P, GLU183O, GLU22O, GLU59P, GLY125P, GLY126P, GLY131P, GLY161O, GLY165O, GLY19P, GLY23O, GLY79P, HIS15O, HIS185O, ILE117P, ILE127O, ILE154O, ILE16O, ILE178O, ILE18O, ILE21P, LEU124O, LEU150O, LEU182O, LEU25O, LEU25P, LEU43O, LEU55P, LEU61P, LEU85P, LEU9P, LYS119O, LYS156O, LYS167O, LYS187O, LYS29P, LYS50P, LYS63P, LYS88P, MET118P, MET121O, MET134O, MET1P, MET57P, MET78P, PHE130P, PHE186O, PHE19O, PHE32O, PHE7P, PRO129P, PRO152O, PRO152P, PRO159O, PRO21O, PRO54P, PRO80P, SER124P, SER125O, SER153O, SER20O, SER51P, SER52P, SER53P, SER58P, SER62P, SER6P, SER8P, THR10P, THR129O, THR157O, THR169O, THR179O, THR17O, THR180O, THR26P, THR2P, THR60P, TYR128O, TYR12O, TYR133O, TYR155O, TYR162O, TYR163O, TYR166O, TYR23P, TYR5P, TYR75P, TYR82P, VAL127P, VAL132P, VAL164O, VAL28O, VAL28P, VAL45O, VAL84P, VAL86P
• O-Q: ALA10O, ALA132O, ARG14O, ARG4Q, ARG5Q, ASP13O, ASP7Q, GLN27O, GLY11O, GLY2Q, HIS15O, ILE16O, ILE18O, SER3Q, SER8Q, TYR12O, TYR133O, TYR6Q
• O-S: ASP9S, TYR12O
• O-U: ALA112U, ALA121U, ALA132O, ALA145U, ALA162U, ALA163U, ALA171U, ALA173U, ALA31O, ALA34O, ALA90O, ALA93O, ALA94O, ARG114U, ARG135O, ARG14O, ARG168U, ARG19U, ARG91O, ARG96O, ASN11U, ASN126U, ASN20U, ASN36O, ASN92O, ASP113U, ASP13O, ASP17U, ASP180U, ASP61O, ASP65O, ASP89O, ASP8U, GLN117U, GLN120U, GLN169U, GLN27O, GLN37O, GLU151U, GLU174U, GLU176U, GLU24U, GLU29O, GLY116U, GLY11O, GLY138O, GLY154U, GLY158U, GLY161U, GLY18U, GLY38U, GLY4U, GLY6U, GLY85O, HIS122U, HIS146U, HIS15O, ILE16O, ILE198U, ILE37U, ILE39U, ILE40O, ILE72O, ILE87O, LEU124U, LEU137O, LEU147U, LEU150U, LEU175U, LEU178U, LEU63O, LEU64O, LEU95O, LEU9U, LYS160U, LYS172U, LYS177U, LYS33O, LYS40U, LYS57O, LYS62O, LYS98O, MET134O, MET149U, PHE14U, PHE32O, PHE73O, PRO109U, PRO136O, PRO152U, PRO159O, PRO16U, PRO60O, PRO66O, PRO86O, PRO88O, SER10U, SER127U, SER12U, SER153U, SER155U, SER15U, SER70O, THR123U, THR17O, THR35O, THR38O, THR5U, THR67O, THR68O, TRP157U, TYR125U, TYR128O, TYR12O, TYR133O, TYR148U, TYR156U, TYR159U, TYR26O, TYR30O, TYR71O, TYR7U, VAL119U, VAL139O, VAL13U, VAL179U, VAL23U, VAL28O, VAL59O, VAL69O
• O-V: ALA101O, ALA102O, ALA54V, ALA56V, ALA94O, ALA97O, ALA99O, ARG105O, ARG36V, ARG77O, ARG96O, ASP111O, ASP39V, ASP57V, CYS74O, GLN53V, GLN60V, GLN69V, GLU100O, GLU103O, GLU64V, GLY71V, HIS38V, HIS62V, ILE55V, ILE58V, ILE75O, LEU63V, LEU65V, LEU95O, LYS107O, LYS40V, LYS98O, MET112O, PHE104O, PHE73O, SER68V, SER76O, THR67V, THR72V, TYR106O, TYR110O, TYR61V, TYR66V, TYR70V, VAL59V
• O-W: ALA118O, ALA122O, ALA79W, ARG105O, ARG120O, ARG72W, ARG75W, ASN123O, ASN62W, ASP104W, ASP111O, ASP115O, ASP147O, CYS114O, GLN81W, GLN85W, GLU103O, GLU148O, GLU149O, GLU73W, GLY109O, GLY151O, HIS66W, ILE59W, ILE63W, LEU117O, LEU124O, LEU150O, LEU65W, LEU68W, LEU80W, LEU83W, LYS107O, LYS119O, LYS230O, LYS84W, MET112O, MET121O, MET82W, PHE104O, PHE88W, PRO105W, PRO113O, PRO74W, SER145O, SER153O, SER67W, SER71W, SER78W, THR106W, THR70W, TYR106O, TYR108O, TYR110O, TYR155O, TYR163O, TYR69W, VAL116O, VAL76W, VAL77W
• P-Q: ALA115P, ALA121P, ALA161P, ALA163P, ALA171P, ALA25Q, ALA82Q, ALA84Q, ARG129Q, ARG178P, ARG4P, ARG4Q, ARG50Q, ARG5Q, ARG92Q, ARG9Q, ASN143P, ASN180P, ASN89Q, ASP151P, ASP181P, ASP209Q, ASP3P, ASP60Q, ASP7Q, ASP83Q, GLN119P, GLN123P, GLN149P, GLN20P, GLN21Q, GLN59Q, GLU113P, GLU120P, GLU176P, GLU23Q, GLU27Q, GLU58Q, GLU64Q, GLU85Q, GLY125P, GLY126P, GLY126Q, GLY127Q, GLY132Q, GLY154P, GLY16P, GLY2Q, GLY36P, GLY79Q, HIS31Q, ILE117P, ILE118Q, ILE21P, ILE29Q, ILE37P, ILE86Q, LEU109P, LEU128Q, LEU147P, LEU175P, LEU18P, LEU26Q, LEU56Q, LEU57Q, LEU80Q, LEU87Q, LEU9P, LYS108P, LYS116P, LYS119Q, LYS160P, LYS172P, LYS177P, LYS17P, LYS38P, LYS51Q, MET118P, PHE12P, PHE131Q, PHE145P, PHE157P, PHE174P, PHE7P, PRO129P, PRO130Q, PRO14P, PRO152P, PRO153Q, PRO158P, SER112P, SER124P, SER13P, SER146P, SER153P, SER155P, SER15P, SER28Q, SER30Q, SER3Q, SER54Q, SER62Q, SER6P, SER8P, SER8Q, THR107P, THR10P, THR10Q, THR11P, THR11Q, THR122P, THR162P, THR173P, THR2P, THR53Q, THR55Q, THR61Q, THR63Q, THR81Q, THR90Q, TRP159P, TRP179P, TYR122Q, TYR148P, TYR156P, TYR208Q, TYR20Q, TYR24Q, TYR5P, TYR67Q, TYR6Q, VAL111P, VAL127P, VAL133Q, VAL150P, VAL22Q, VAL52Q
• P-R: ARG4P, ARG6R, ASP3P, ASP5R, GLY125P, GLY3R, PHE7P, SER6P, SER8P, THR2P, TYR4R, TYR5P
• P-S: ALA127S, ARG4P, GLU125S, GLY124S, GLY126S, MET1P, SER128S
• P-T: ARG4P, GLN121T, GLY124T, GLY125T, MET1P, PHE7P, SER122T, THR2P, TYR123T, VAL11T
• P-U: ALA121U, ARG129U, ARG4P, ASN126U, ASP3P, HIS122U, LEU124U, MET1P, SER10U, SER127U, SER12U, THR2P, TYR125U, TYR5P, VAL128U, VAL13U
• P-W: ALA184W, ALA32W, ALA93P, ARG188W, ARG36W, ARG83P, ARG90P, ARG99P, ASN62W, ASP183W, ASP220P, ASP230P, ASP87P, CYS176W, GLN57W, GLU103P, GLU185W, GLU64W, GLU73W, GLY102P, GLY223P, GLY226P, GLY60W, HIS35W, HIS66W, HIS94P, ILE100P, ILE227P, ILE37W, ILE41W, ILE59W, ILE63W, LEU187W, LEU221P, LEU222P, LEU34W, LEU58W, LEU65W, LEU66P, LEU67P, LEU68W, LYS182W, LYS237P, LYS40W, LYS88P, LYS91P, LYS98P, MET178W, MET82W, PRO219P, PRO228P, PRO39W, PRO69P, SER38W, SER61W, SER62P, SER65P, SER67W, SER71W, SER89P, THR225P, THR229P, THR60P, THR68P, THR70W, THR95P, TRP42W, TYR101P, TYR104P, TYR186W, TYR224P, TYR69W, VAL103W, VAL177W, VAL84P, VAL86P, VAL92P
• P-X: ALA72X, ARG71X, ARG99P, ASN104X, ASN143P, ASP140P, GLN80X, GLU103P, GLU113P, GLU123X, GLU141P, GLU69X, GLU70X, GLU74X, GLU76X, GLU88X, GLY102P, GLY144P, HIS139P, HIS39X, ILE100P, ILE121X, ILE73X, LEU109P, LEU64X, LEU67X, LEU81X, LYS106X, LYS108P, LYS109X, LYS61X, LYS66X, LYS68X, LYS98P, PHE142P, PHE58X, PHE78X, PRO105P, PRO106P, PRO75X, SER105X, SER107X, SER112P, SER83X, SER84X, SER85X, SER96P, THR229P, THR62X, THR77X, THR79X, TYR101P, TYR104P, TYR65X, TYR87X, TYR97P, VAL82X
• Q-R: ALA162Q, ALA172Q, ALA23R, ALA26R, ALA40Q, ALA7R, ALA80R, ARG113Q, ARG114Q, ARG127R, ARG143Q, ARG18Q, ARG29R, ARG49R, ARG4Q, ARG58R, ARG5Q, ARG6R, ARG83R, ARG90R, ARG9Q, ASN152Q, ASN156Q, ASN79R, ASP117Q, ASP141Q, ASP179Q, ASP182Q, ASP56R, ASP5R, ASP7Q, ASP81R, GLN117R, GLN120Q, GLN124Q, GLN147Q, GLN173Q, GLN177Q, GLN19R, GLN55R, GLU109Q, GLU16Q, GLU21R, GLU23Q, GLU25R, GLU87R, GLY121Q, GLY124R, GLY125R, GLY126Q, GLY127Q, GLY130R, GLY139Q, GLY145Q, GLY155Q, GLY159Q, GLY17Q, GLY3R, HIS125Q, ILE10R, ILE118Q, ILE12Q, ILE163Q, ILE38Q, ILE44Q, ILE59R, ILE84R, LEU115Q, LEU128Q, LEU148Q, LEU175Q, LEU176Q, LEU192Q, LEU19Q, LEU24R, LEU52R, LEU54R, LEU78R, LEU85R, LEU8R, LYS119Q, LYS161Q, LYS181Q, LYS28R, LYS53R, LYS63R, LYS88R, MET178Q, MET39Q, PHE129R, PHE13Q, PHE18R, PHE75R, PRO128R, PRO152R, PRO153Q, PRO15Q, PRO61R, SER116Q, SER14Q, SER151Q, SER154Q, SER164Q, SER170Q, SER3Q, SER62R, SER82R, SER8Q, SER9R, THR10Q, THR11Q, THR121R, THR123Q, THR150Q, THR158Q, THR169Q, THR174Q, THR51R, THR57R, THR60R, TRP160Q, TYR120R, TYR122Q, TYR144Q, TYR146Q, TYR149Q, TYR157Q, TYR180Q, TYR20Q, TYR22R, TYR4R, TYR6Q, VAL108Q, VAL112Q, VAL116R, VAL126R, VAL131R, VAL20R, VAL22Q, VAL27R
• Q-S: ARG10S, ARG4Q, ARG5Q, ARG9Q, ASP7Q, ASP9S, GLU125S, GLY11S, GLY124S, GLY126S, SER13S, SER3Q, THR14S, TYR6Q, VAL12S
• Q-T: ARG4Q, ARG5Q, ASN4T, ASN5T, ASP7Q, ASP9T, GLY124T, GLY125T, GLY2Q, GLY8T, SER3Q, THR10T, THR12T, TYR123T, TYR6T, VAL11T
• Q-U: ARG4Q, ARG5Q, ASN11U, ASN126U, ASP8U, GLN22U, GLY2Q, GLY6U, LEU9U, SER10U, SER127U, SER3Q, TYR125U, TYR6Q, TYR7U, VAL128U, VAL13U
• Q-W: ASN219W, ASP222Q, ASP222W, ASP71Q, CYS221W, GLN227Q, GLU224Q, LYS68Q, TYR226Q, VAL225Q
• Q-X: ALA74Q, ALA91Q, ALA95Q, ARG59X, ARG92Q, ASN103Q, ASN55X, ASN63X, ASN70Q, ASN89Q, ASN97Q, ASP105Q, ASP71Q, GLN227Q, GLN96Q, GLU104Q, GLU56X, GLU69X, GLU70X, HIS94Q, ILE229Q, ILE73Q, ILE88Q, ILE93Q, LEU54X, LEU64X, LEU66Q, LEU67X, LEU69Q, LEU99Q, LYS100Q, LYS61X, LYS66X, LYS68Q, LYS68X, LYS72Q, MET57X, PHE58X, SER62Q, THR101Q, THR52X, THR53X, THR61Q, THR62X, THR63Q, THR90Q, TYR102Q, TYR60X, TYR65X, TYR67Q, TYR98Q
• Q-Y: ALA78Y, ALA88Y, ARG113Q, ARG143Q, ARG69Y, ARG84Y, ASN103Q, ASN62Y, ASN97Q, ASP105Q, ASP107Y, ASP117Q, ASP141Q, ASP142Q, ASP71Y, GLN77Y, GLN85Y, GLN96Q, GLU104Q, GLU109Q, GLU70Y, GLU73Y, GLU86Y, HIS94Q, ILE106Q, ILE110Q, ILE63Y, ILE68Y, LEU74Y, LEU99Q, LYS100Q, LYS109Y, LYS110Y, LYS124Y, LYS89Y, PHE82Y, PRO107Q, PRO76Y, SER67Y, SER75Y, SER80Y, SER81Y, THR101Q, TYR102Q, TYR144Q, TYR66Y, TYR72Y, TYR98Q, VAL79Y, VAL83Y
• R-S: ALA114R, ALA127S, ALA161R, ALA30S, ALA54S, ALA7R, ALA83S, ALA85S, ARG10S, ARG111R, ARG119R, ARG132S, ARG136S, ARG172R, ARG181R, ARG6R, ARG86S, ARG93S, ASN178R, ASN215S, ASP14R, ASP180R, ASP5R, ASP62S, ASP84S, ASP9S, GLN117R, GLN118R, GLN122R, GLN149R, GLN162R, GLN19R, GLN23S, GLU107R, GLU125S, GLU144R, GLU151R, GLU173R, GLU176R, GLU21R, GLU25S, GLU29S, GLU60S, GLU65S, GLU90S, GLY115R, GLY11S, GLY124R, GLY124S, GLY125R, GLY126S, GLY139S, GLY154R, GLY15R, GLY35R, GLY80S, HIS16R, ILE10R, ILE155R, ILE17R, ILE31S, ILE64S, LEU119S, LEU133S, LEU147R, LEU175R, LEU194R, LEU28S, LEU33S, LEU58S, LEU59S, LEU81S, LEU8R, LYS146R, LYS169R, LYS177R, LYS32S, LYS37R, LYS66S, MET134S, MET78S, MET88S, PHE11R, PHE123S, PHE138S, PHE174R, PHE22S, PRO128R, PRO137S, PRO13R, PRO145R, PRO152R, PRO160S, PRO57S, SER123R, SER12R, SER135S, SER153R, SER157R, SER158R, SER160R, SER27S, SER56S, SER61S, SER63S, SER87S, SER9R, THR121R, THR163R, THR55S, THR82S, TRP159R, TYR120R, TYR148R, TYR156R, TYR179R, TYR26S, TYR4R, VAL126R, VAL12S, VAL140S, VAL171R, VAL20R, VAL24S, VAL34R, VAL36R
• R-T: ARG6R, TYR123T
• R-Y: ALA56Y, ALA61Y, ALA89R, ALA93R, ARG35Y, ARG69Y, ARG90R, ARG97R, ASN62Y, ASP68R, ASP71Y, GLN54Y, GLN60Y, GLN64Y, GLN94R, GLU101R, GLU57Y, GLU70Y, GLU87R, GLU92R, HIS70R, ILE59Y, ILE63Y, ILE67R, ILE68Y, ILE86R, LEU65Y, LEU98R, LYS66R, LYS88R, PHE55Y, SER219R, SER65R, SER67Y, SER69R, SER95R, THR99R, TYR58Y, TYR66Y, VAL53Y, VAL71R, VAL91R
• R-Z: ALA77Z, ALA78Z, ALA79Z, ARG111R, ARG121Z, ARG141R, ARG69Z, ARG97R, ASN85Z, ASP102R, ASP139R, GLU101R, GLU107R, GLU108Z, GLU70Z, GLU72Z, HIS66Z, HIS96R, ILE74Z, ILE82Z, LEU100R, LEU68Z, LEU98R, LYS107Z, LYS123Z, LYS71Z, LYS81Z, SER75Z, SER80Z, SER95R, THR105R, THR99R, TYR108R, TYR113Z, TYR156R, VAL104R, VAL76Z
• S-T: ALA120S, ALA127S, ALA169S, ALA171S, ALA181S, ALA25T, ALA28T, ALA41S, ALA53T, ALA78T, ALA81T, ARG10S, ARG122S, ARG126T, ARG132S, ARG166S, ARG20S, ARG3T, ARG51T, ARG82T, ARG89T, ASN119T, ASN168S, ASN185S, ASN4T, ASN52T, ASN86T, ASP118S, ASP54T, ASP7T, ASP80T, ASP9S, ASP9T, CYS117S, GLN114S, GLN121T, GLN180S, GLN21T, GLN31T, GLN60T, GLN90T, GLU110S, GLU125S, GLU130S, GLU159S, GLU177S, GLU182S, GLU186S, GLU18S, GLU23T, GLU25S, GLU27T, GLU55T, GLY11S, GLY124S, GLY124T, GLY125T, GLY126S, GLY129S, GLY129T, GLY162S, GLY19S, GLY39S, GLY76T, GLY8T, HIS157S, HIS188S, ILE29T, ILE40S, ILE64T, LEU121S, LEU155S, LEU183S, LEU184S, LEU21S, LEU26T, LEU56T, LEU74T, LEU77T, LYS115T, LYS118T, LYS170S, LYS30T, LYS50T, LYS61T, PHE123S, PHE156S, PHE15S, PHE164S, PHE20T, PHE22S, PRO127T, PRO149T, PRO160S, PRO17S, PRO79T, SER111S, SER115S, SER122T, SER128S, SER13S, SER161S, SER16S, SER57T, SER58T, THR10T, THR120T, THR14S, THR163S, TRP187S, TYR123T, TYR128T, TYR165S, TYR167S, TYR24T, TYR59T, VAL12S, VAL130T, VAL22T, VAL24S, VAL83T
• S-U: SER127U, SER128S
• S-Z: ALA92S, ALA95S, ALA96S, ARG64Z, ARG69Z, ARG72S, ARG86S, ARG93S, ASN100S, ASP104S, ASP62S, ASP71S, CYS63Z, GLN53Z, GLN62Z, GLU56Z, GLU65S, GLU67Z, GLU69S, GLU70Z, GLU90S, GLY227S, GLY60Z, GLY75S, HIS66Z, HIS73S, HIS91S, HIS99S, ILE230S, ILE70S, ILE74S, ILE89S, LEU101S, LEU59Z, LEU65Z, LEU68Z, LYS71Z, PHE228S, PHE54Z, SER61Z, SER63S, THR57Z, THR94S, THR98S, TRP55Z, TRP58Z, TYR102S, VAL68S, VAL97S
• S-1: ALA149S, ALA801, ALA811, ALA95S, ARG821, ASN100S, ASN108S, ASN711, ASN781, ASN831, ASP104S, ASP106S, ASP148S, ASP150S, ASP151S, ASP691, GLN114S, GLN154S, GLN851, GLU105S, GLU1071, GLU110S, HIS701, HIS861, HIS99S, ILE107S, ILE771, ILE841, LEU101S, LEU112S, LEU751, LEU871, LYS731, LYS741, PHE591, PHE681, SER111S, SER115S, SER621, SER761, SER791, THR98S, TRP651, TYR102S, TYR103S, TYR1141, TYR1221, TYR661, VAL109S, VAL631, VAL97S
• T-U: ALA116T, ALA142T, ALA160T, ALA168T, ALA26U, ALA29U, ARG107T, ARG129U, ARG174T, ARG18T, ARG39T, ARG3T, ARG85U, ARG92U, ASN119T, ASN11U, ASN126U, ASN152T, ASN32U, ASN4T, ASN5T, ASN63U, ASN89U, ASP114T, ASP177T, ASP7T, ASP83U, ASP8U, ASP9T, CYS113T, GLN117T, GLN121T, GLN148T, GLN166T, GLN22U, GLN61U, GLN67U, GLU106T, GLU146T, GLU155T, GLU173T, GLU24U, GLU31U, GLU93U, GLY109T, GLY124T, GLY125T, GLY132U, GLY151T, GLY158T, GLY17T, GLY37T, GLY6U, GLY79U, GLY84U, GLY8T, HIS110T, HIS122U, HIS143T, HIS86U, ILE180T, ILE53U, ILE81U, LEU111T, LEU112T, LEU144T, LEU145T, LEU156T, LEU172T, LEU176T, LEU19T, LEU38T, LEU52U, LEU57U, LEU58U, LEU80U, LEU87U, LEU9U, LYS115T, LYS118T, LYS169T, LYS28U, LYS56U, LYS62U, LYS65U, PHE131U, PHE13T, PHE179T, PHE21U, PHE2T, PRO127T, PRO130U, PRO149T, PRO152U, PRO15T, PRO60U, PRO82U, SER10U, SER122T, SER127U, SER140T, SER14T, SER150T, SER55U, THR10T, THR120T, THR12T, THR154T, THR159T, THR16T, THR170T, THR175T, THR54U, THR5U, TYR118U, TYR123T, TYR125U, TYR157T, TYR171T, TYR25U, TYR6T, TYR7U, VAL119U, VAL11T, VAL128U, VAL133U, VAL153T, VAL22T, VAL23U, VAL27U, VAL30U, VAL36T, VAL59U, VAL64U
• T-1: ALA541, ARG581, ARG82T, ARG89T, ASN100T, ASN611, ASN711, ASN86T, ASN93T, ASP226T, ASP67T, ASP691, ASP721, CYS66T, CYS92T, GLN90T, GLN91T, GLU68T, HIS671, HIS69T, HIS701, ILE224T, ILE64T, LEU88T, LEU97T, LYS102T, LYS571, LYS601, LYS61T, LYS641, LYS65T, MET70T, PHE222T, PHE681, PHE99T, SER621, SER85T, SER96T, THR223T, TRP651, TYR87T, TYR94T, VAL98T
• T-2: ALA104T, ALA672, ALA732, ALA752, ALA782, ALA892, ARG101T, ARG107T, ASN100T, ASN1142, ASN662, ASN702, ASP114T, ASP138T, ASP692, GLN1122, GLN942, GLU106T, GLU155T, GLU652, GLU762, GLU772, GLU802, GLU862, GLY141T, HIS110T, HIS143T, ILE842, LEU103T, LEU592, LEU622, LEU722, LEU792, LEU882, LEU97T, LYS102T, LYS139T, PHE1182, PHE852, PHE99T, PRO712, PRO812, SER1132, SER140T, SER822, SER95T, SER96T, THR902, TYR682, TYR832, TYR872, TYR94T, VAL105T, VAL912, VAL98T
• U-V: ALA110U, ALA78V, ALA79V, ARG114U, ASN106V, ASN143U, ASP103V, ASP113U, GLN117U, GLN69V, GLU76V, GLU84V, GLU88V, GLU94U, GLY71V, HIS62V, ILE106U, ILE58V, LEU101U, LEU63V, LEU65V, LEU85V, LYS100U, LYS103U, LYS105V, LYS142U, LYS83V, LYS99U, PHE111U, PHE82V, PHE98U, PRO105U, PRO107U, PRO109U, PRO73V, SER74V, SER80V, THR104U, THR67V, THR72V, THR77V, TYR102U, TYR111V, TYR61V, TYR66V, TYR70V, TYR87V, VAL119V, VAL59V, VAL81V
• U-2: ALA672, ALA732, ALA752, ALA95U, ALA96U, ARG572, ARG71U, ARG85U, ARG92U, ASN63U, ASN662, ASN702, ASN89U, ASP612, ASP692, ASP70U, ASP742, GLN532, GLN61U, GLN67U, GLU562, GLU652, GLU93U, GLY382, GLY91U, HIS227U, HIS542, HIS72U, ILE66U, ILE73U, LEU101U, LEU582, LEU592, LEU622, LEU722, LEU792, LYS100U, LYS103U, LYS228U, LYS231U, LYS602, LYS62U, LYS65U, LYS99U, PHE229U, PRO712, SER97U, THR642, TYR682, TYR77U, VAL632, VAL64U, VAL68U, VAL69U, VAL88U
• V-W: ALA115W, ALA133W, ALA134W, ALA136W, ALA24V, ALA27V, ALA49V, ALA50V, ALA54V, ALA56V, ARG174V, ARG29V, ARG45V, ASN28V, ASN89V, ASN92V, ASP120W, ASP32V, ASP51V, ASP57V, GLN53V, GLN60V, GLN81W, GLN85W, GLN91W, GLU-5V, GLU139W, GLY-6V, GLY117W, GLY122W, GLY128W, GLY92W, HIS114W, HIS116W, HIS93W, ILE113W, ILE26V, ILE55V, ILE58V, LEU-2V, LEU125W, LEU127W, LEU132W, LEU138W, LEU80W, LEU87W, LEU93V, LYS-7V, LYS-8V, LYS84W, MET135W, PHE88W, SER-3V, SER112W, SER118W, SER126W, SER131W, SER48V, THR119W, THR20V, THR22V, THR31V, THR52V, THR94V, TRP142W, TYR123W, TYR124W, TYR25V, TYR61V, TYR90W, TYR97W, VAL-4V, VAL121W, VAL30V
• V-2: ALA125V, ALA127V, ARG272, ARG572, ARG952, ASN1002, ASN292, ASP139V, ASP482, ASP512, ASP91V, CYS86V, GLN-62, GLN-72, GLN532, GLU562, GLU84V, GLU88V, GLY116V, GLY117V, GLY128V, GLY202, GLY302, GLY96V, HIS120V, HIS542, ILE-42, ILE113V, ILE126V, ILE3V, ILE492, ILE552, ILE97V, ILE98V, LEU1022, LEU115V, LEU122V, LEU252, LEU262, LEU582, LYS121V, LYS83V, LYS90V, MET522, MET992, PHE282, PRO-52, PRO1012, PRO114V, SER118V, SER129V, SER131V, SER46V, SER502, SER80V, THR-22, THR-82, THR112V, THR132V, THR94V, TRP1032, TYR124V, TYR135V, TYR222, TYR87V, VAL-32, VAL119V, VAL312
• W-X: ALA124X, ALA161X, ALA176X, ALA211W, ALA27W, ALA32W, ALA49W, ALA50W, ALA54W, ALA72X, ALA96W, ARG188W, ARG189X, ARG196W, ARG207W, ARG90X, ASN148X, ASN164X, ASN189W, ASN219W, ASN30W, ASP116X, ASP122X, ASP126X, ASP135X, ASP153X, ASP184X, ASP222W, ASP28W, ASP51W, CYS120X, CYS141X, CYS221W, CYS31W, GLN136X, GLN160X, GLN195X, GLN22W, GLN57W, GLN80X, GLU123X, GLU142X, GLU146X, GLU150X, GLU152X, GLU156X, GLU185X, GLU215W, GLU32X, GLU53W, GLY119X, GLY131X, GLY139X, GLY175X, GLY208W, GLY38X, GLY92W, GLY95W, HIS36X, HIS39X, HIS86W, HIS93W, ILE118X, ILE121X, ILE128X, ILE158X, ILE180X, ILE181X, ILE217W, ILE220W, ILE25W, ILE34X, ILE94W, LEU117X, LEU144X, LEU149X, LEU154X, LEU162X, LEU163X, LEU18X, LEU191X, LEU213W, LEU58W, LEU86X, LYS125X, LYS182X, LYS183X, LYS188X, LYS192X, LYS199W, LYS201W, LYS204W, LYS214W, LYS29W, LYS30X, LYS66X, MET140X, MET193X, MET6X, PHE115X, PHE127X, PHE138X, PHE155X, PHE205W, PHE41X, PHE91X, PRO147X, PRO151X, PRO206W, PRO24W, SER105X, SER130X, SER134X, SER143X, SER159X, SER202W, SER20W, SER216W, SER83X, SER84X, THR157X, THR209W, THR210W, THR21W, THR48W, THR52W, TYR145X, TYR179X, TYR190X, TYR203W, TYR37X, TYR87X, TYR90W, VAL129X, VAL177X, VAL178X, VAL186X, VAL187X, VAL212W, VAL218W, VAL26W, VAL40X, VAL55W
• X-Y: ALA131Y, ALA48X, ALA88Y, ARG59X, ARG7Y, ARG84Y, ARG89X, ARG92Y, ASN-2X, ASN29X, ASN55X, ASP119Y, ASP144Y, ASP50X, GLN117Y, GLN23X, GLN85Y, GLU126Y, GLU32X, GLU56X, GLY122Y, GLY130Y, GLY133Y, GLY136Y, GLY21X, GLY26X, GLY92X, HIS132Y, ILE-3X, ILE118Y, ILE91Y, LEU117X, LEU121Y, LEU127Y, LEU20X, LEU25X, LEU47X, LEU54X, LEU87Y, LYS124Y, LYS30X, LYS89Y, MET57X, PHE137Y, PHE140Y, PHE31X, PHE91X, PHE95X, PRO-6X, PRO128Y, PRO93X, SER135Y, SER141Y, SER22X, SER24X, SER28X, SER81Y, THR123Y, THR139Y, THR49X, THR52X, THR53X, TRP174X, TYR120Y, TYR129Y, TYR134Y, TYR138Y, TYR60X, TYR94X, VAL125Y, VAL27X, VAL51X, VAL96X
• Y-Z: ALA49Y, ALA93Z, ARG121Z, ARG22Y, ARG35Y, ARG94Y, ARG95Y, ASN85Z, ASP116Z, ASP118Z, ASP125Z, ASP29Y, ASP31Y, ASP32Y, ASP51Y, CYS128Z, GLN133Z, GLN54Y, GLN60Y, GLN89Z, GLN98Y, GLU48Y, GLU57Y, GLY119Z, GLY124Z, GLY130Z, GLY23Y, GLY50Y, GLY92Z, GLY98Z, ILE126Z, ILE24Y, LEU122Z, LEU27Y, LEU86Z, LYS123Z, LYS28Y, LYS33Y, LYS81Z, LYS91Z, MET100Z, PHE127Z, PHE135Z, PHE55Y, PRO96Y, SER117Z, SER131Z, SER25Y, SER30Y, SER84Z, THR120Z, THR134Z, THR21Y, THR52Y, TYR113Z, TYR114Z, TYR137Z, TYR58Y, TYR88Z, TYR90Z, TYR97Y, VAL115Z, VAL129Z, VAL20Y, VAL26Y, VAL53Y, VAL87Z, VAL99Y
• Z-1: ALA1291, ALA1331, ALA1341, ALA20Z, ALA22Z, ALA27Z, ALA49Z, ALA50Z, ALA93Z, ARG1241, ARG1281, ARG33Z, ARG821, ARG921, ASN1461, ASN1491, ASP1171, ASP1421, ASP192Z, ASP51Z, CYS52Z, GLN1261, GLN29Z, GLN53Z, GLN851, GLU1231, GLU1251, GLU195Z, GLU202Z, GLU36Z, GLU56Z, GLY1201, GLY1301, GLY173Z, GLY194Z, GLY212Z, GLY48Z, GLY901, GLY92Z, GLY94Z, HIS861, HIS991, ILE1371, ILE35Z, LEU1361, LEU86Z, LEU871, LEU881, LEU95Z, LYS1481, LYS1581, LYS1601, LYS32Z, MET1381, MET45Z, MET97Z, PHE1161, PHE1401, PHE54Z, PHE931, PRO1181, PRO1391, SER1151, SER117Z, SER1211, SER1351, SER18Z, SER28Z, SER61Z, SER96Z, THR30Z, THR57Z, TRP198Z, TRP25Z, TRP55Z, TRP58Z, TYR1221, TYR1511, TYR891, TYR90Z, VAL1191, VAL26Z, VAL31Z, VAL34Z
• 1-2: ALA1352, ALA1402, ALA491, ALA501, ALA541, ALA892, ARG1202, ARG1482, ARG1532, ARG191, ARG2121, ARG291, ARG581, ARG952, ARG962, ASN-21, ASN-71, ASN1002, ASN1042, ASN1232, ASN1442, ASN201, ASN271, ASP-31, ASP1522, ASP1562, ASP1911, ASP231, ASP511, ASP531, GLN-62, GLN-72, GLN-91, GLN942, GLU1542, GLU2091, GLU311, GLU862, GLY-41, GLY1262, GLY1372, GLY471, GLY521, HIS1412, ILE211, ILE261, LEU1022, LEU1242, LEU1252, LEU1342, LEU2101, LEU551, LYS571, LYS911, LYS982, MET922, MET992, PHE-81, PHE2071, PHE351, PHE481, PHE852, PHE941, PRO-52, PRO-61, PRO1012, PRO1322, PRO1452, PRO321, PRO951, SER1302, SER1312, SER251, SER281, SER972, THR-82, THR1282, THR1332, THR221, THR902, TRP1032, TYR-51, TYR1212, TYR1292, TYR241, TYR301, TYR872, TYR932, TYR961, TYR971, VAL1222, VAL1272, VAL1512, VAL981