1RV1

crystal structure of human mdm2 with an imidazoline inhibitor

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 34
  • Norm. En. per Res.: -4.7234
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-48.1244	-33.453	-79.0171	-160.5944	34	21	1	3865	1	14	10
A-C	0.0	15.7166	-51.8465	-36.1299	38	1	0	2393	0	11	27
B-C	0.0	0.0	-0.3006	-0.3006	3	0	0	33	0	0	0

Interface residues

• A-B: ARG29A, ARG29B, ASP46A, ASP46B, CB5.19563-76.07056, GLU25A, GLU25A5, GLU25B, LEU107A, LEU107B, LEU27A, LEU27B, LYS45A, LYS45B, MET50A, MET50B, PRO30A, PRO30B, THR26A, THR26B, THR47A, THR47B, THR49A, THR49B, TYR104A, TYR104B, TYR48A, TYR48B, VAL108A, VAL108B, VAL109A, VAL109B, VAL28A, VAL28B
• A-C: ARG97A, ARG97C, GLN59A, GLN59C, GLN71C, GLN72A, GLN72C, GLU95A, GLU95C, GLY58A, GLY58C, HIS73A, HIS73C, HIS96A, HIS96C, ILE74A, ILE74C, ILE99A, LEU54A, LYS51A, LYS51C, LYS94A, LYS94C, LYS98A, LYS98C, MET50A, MET62A, MET62C, PHE55A, PHE55C, SER92A, SER92C, THR63A, THR63C, TYR100A, TYR100C, VAL93A, VAL93C
• B-C: ARG65C, TYR104B, VAL109B