1RU7

1934 human h1 hemagglutinin

• Total interactions analyzed: 66
• Total true interactions: 30
• Strongest Interaction:
  • Chains: J-K
  • Int. Res.: 41
  • Norm. En. per Res.: -3.9827
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-242.4444	-42.9574	-81.9822	-367.3839	234	63	27	31787	6	52	40
A-C	-4.953	-26.0368	-73.8585	-104.8483	50	3	1	3993	2	16	15
A-D	0.0	0.0	-59.7419	-59.7419	36	2	0	2627	1	7	7
A-E	0.0	-12.304	-80.5643	-92.8683	49	0	1	3872	0	15	14
A-F	-35.4651	-38.3572	-84.247	-158.0693	40	3	0	2986	1	21	16
B-C	-36.587	-36.3162	-82.4236	-155.3268	41	3	0	3012	1	20	16
B-D	-74.475	-80.8363	-225.582	-380.8933	123	8	3	10124	9	41	38
B-E	-3.9757	0.0	-59.074	-63.0497	36	1	0	2533	1	7	7
B-F	-57.2465	-72.0468	-207.491	-336.7843	123	9	3	9780	7	41	38
C-D	-234.3635	-28.2196	-88.8311	-351.4141	228	52	28	31676	6	51	43
C-E	0.0	-14.7432	-78.5253	-93.2686	52	0	1	3922	0	16	15
C-F	-2.4179	0.0	-62.1154	-64.5333	36	1	0	2589	1	7	7
D-E	-41.9993	-39.0849	-85.5801	-166.6642	43	4	0	3108	1	21	16
D-F	-58.7527	-97.0042	-217.876	-373.6329	122	10	3	9865	9	41	39
E-F	-270.3707	-45.8205	-115.164	-431.3552	221	50	29	32117	5	52	41
G-H	-247.9119	-38.6248	-83.038	-369.5746	228	67	28	31675	5	53	41
G-I	-4.696	-27.939	-79.2496	-111.8846	50	5	1	3972	2	15	15
G-J	-7.2114	0.0	-63.1655	-70.3769	36	0	0	2662	2	7	7
G-K	0.0	-11.4179	-82.6415	-94.0594	51	0	1	3899	1	16	14
G-L	-35.6113	-38.4864	-79.9381	-154.0358	42	3	0	3006	1	20	16
H-I	-34.4001	-36.0288	-81.4822	-151.9111	41	3	0	2992	1	20	16
H-J	-74.7506	-81.0793	-232.847	-388.6769	125	9	3	10337	10	41	40
H-K	-2.8181	0.0	-61.516	-64.3341	37	0	0	2536	1	7	7
H-L	-59.2497	-71.8844	-221.934	-353.0681	123	7	3	9903	8	41	38
I-J	-247.5722	-30.4459	-85.57	-363.5882	225	58	27	31866	5	53	41
I-K	0.0	-15.2005	-75.5023	-90.7028	50	0	1	3830	0	16	14
I-L	0.0	0.0	-63.0517	-63.0517	36	0	0	2634	1	7	7
J-K	-37.2167	-38.3659	-87.7062	-163.2888	41	3	0	3081	1	21	16
J-L	-50.9808	-95.4291	-212.218	-358.6279	123	10	2	9749	8	41	38
K-L	-285.5664	-44.2971	-97.9035	-427.767	225	51	28	32020	5	53	43

Interface residues

• A-B: ALA13A, ALA313A, ALA326A, ALA505B, ALA507B, ALA535B, ALA536B, ALA544B, ALA565B, ALA596B, ALA630B, ARG106A, ARG311A, ARG316A, ARG322A, ARG327A, ARG606B, ARG653B, ASN14A, ASN15A, ASN27A, ASN297A, ASN323A, ASN35A, ASN528B, ASN553B, ASN560B, ASN571B, ASN582B, ASN595B, ASN604B, ASN60A, ASN614B, ASN617B, ASN635B, ASN646B, ASP101A, ASP21A, ASP519B, ASP537B, ASP585B, ASP586B, ASP590B, ASP5A, ASP5A5, ASP609B, ASP612B, ASP645B, ASP98A, CB4.19979-8.74034, CB6.9048954.71488, CB7.655075.02328, CB8.0370422.89799, CB8.12749-15.46863, CB8.23782-7.23848, CYS282A, CYS306A, CYS637B, CYS644B, CYS648B, CYS8A, GLN283A, GLN296A, GLN527B, GLN530B, GLN562B, GLU103A, GLU104A, GLU107A, GLU25A, GLU305A, GLU511B, GLU529B, GLU557B, GLU569B, GLU574B, GLU578B, GLU597B, GLU603B, GLU605B, GLU620B, GLU639B, GLU650B, GLU85A, GLY10A, GLY265A, GLY267A, GLY304A, GLY320A, GLY501B, GLY508B, GLY512B, GLY513B, GLY516B, GLY520B, GLY523B, GLY531B, GLY533B, GLY567B, GLY587B, GLY634B, GLY636B, HIS12A, HIS299A, HIS32A, HIS525B, HIS526B, HIS611B, HIS642B, ILE100A, ILE268A, ILE269A, ILE303A, ILE324A, ILE506B, ILE510B, ILE518B, ILE545B, ILE548B, ILE556B, ILE561B, ILE591B, ILE61A, ILE633B, ILE7A, ILE83A, ILE9A, LEU24A, LEU293A, LEU315A, LEU321A, LEU36A, LEU37A, LEU48A, LEU502B, LEU573B, LEU589B, LEU598B, LEU599B, LEU601B, LEU602B, LEU608B, LEU618B, LEU626B, LYS26A, LYS281A, LYS308A, LYS314A, LYS49A, LYS551B, LYS558B, LYS568B, LYS572B, LYS616B, LYS621B, LYS623B, LYS631B, LYS643B, MET317A, MET517B, MET559B, MET577B, MET649B, PHE264A, PHE509B, PHE563B, PHE570B, PHE588B, PHE610B, PHE638B, PHE640B, PHE99A, PRO285A, PRO294A, PRO300A, PRO307A, PRO325A, SER110A, SER16A, SER266A, SER291A, SER292A, SER312A, SER33A, SER532B, SER540B, SER554B, SER651B, SER81A, THR19A, THR22A, THR270A, THR284A, THR29A, THR302A, THR319A, THR31A, THR515B, THR541B, THR549B, THR564B, THR593B, THR607B, THR6A, TRP514B, TRP521B, TRP592B, TYR102A, TYR11A, TYR295A, TYR309A, TYR522B, TYR524B, TYR534B, TYR594B, TYR619B, TYR641B, TYR657B, TYR82A, VAL20A, VAL23A, VAL28A, VAL301A, VAL30A, VAL310A, VAL318A, VAL34A, VAL552B, VAL555B, VAL566B, VAL600B, VAL615B, VAL622B, VAL652B
• A-C: ALA218A, ALA227A, ARG211C, ARG212C, ARG220A, ARG224A, ARG229A, ASN187A, ASN208C, ASN210C, ASN231A, ASP241C, ASP98A, GLN226A, GLU216A, GLU219A, GLU246C, GLY228A, GLY240C, GLY97A, HIS184A, ILE217A, ILE243C, ILE244C, ILE93A, LEU237C, LYS163C, LYS165C, LYS222A, MET230A, PHE213C, PRO186A, PRO215A, PRO221A, PRO96A, SER167C, SER188A, SER203C, SER207C, THR206C, THR214A, THR214C, THR242C, TYR168C, TYR201C, TYR209C, VAL169C, VAL204C, VAL205C, VAL223A
• A-D: ALA313A, ALA544D, ARG311A, ARG606D, ASN27A, ASN543D, ASN546D, ASN550D, ASN553D, ASN560D, ASN614D, ASP21A, GLU25A, GLU557D, GLU603D, GLY547D, ILE545D, ILE548D, LEU24A, LEU315A, LEU599D, LYS26A, LYS314A, LYS551D, LYS558D, PHE610D, SER312A, SER554D, THR22A, THR549D, THR607D, TRP592D, VAL23A, VAL28A, VAL552D, VAL555D
• A-E: ALA218E, ALA227E, ARG211A, ARG212A, ARG220E, ARG224E, ARG229E, ASN208A, ASN210A, ASN231E, ASP241A, ASP98E, GLN226E, GLU216E, GLU219E, GLU246A, GLY228E, GLY240A, GLY97E, HIS184E, ILE217E, ILE243A, ILE244A, LEU237A, LYS163A, LYS165A, LYS222E, LYS238A, MET230E, PHE213A, PRO186E, PRO215E, PRO221E, PRO96E, SER167A, SER203A, SER207A, THR206A, THR214A, THR214E, THR242A, TYR168A, TYR201A, TYR209A, TYR233E, VAL169A, VAL204A, VAL205A, VAL223E
• A-F: ARG106A, ARG211A, ARG262A, ARG576F, ASN208A, ASN210A, ASN571F, ASN579F, ASP101A, ASP590F, GLN108A, GLU103A, GLU104A, GLU107A, GLU574F, GLU578F, GLY587F, ILE100A, ILE591F, LEU105A, LEU109A, LEU236A, LEU573F, LEU580F, LYS238A, LYS308A, LYS572F, LYS575F, MET577F, PRO294A, SER110A, SER111A, SER207A, THR206A, THR235A, TRP234A, TYR102A, TYR209A, TYR295A, TYR594F
• B-C: ARG106C, ARG211C, ARG262C, ARG576B, ASN208C, ASN210C, ASN571B, ASN579B, ASP101C, ASP590B, GLN108C, GLU103C, GLU104C, GLU107C, GLU574B, GLU578B, GLY587B, ILE100C, ILE591B, LEU105C, LEU109C, LEU236C, LEU237C, LEU573B, LEU580B, LYS238C, LYS308C, LYS572B, LYS575B, MET577B, PRO294C, SER110C, SER111C, SER207C, THR206C, THR235C, TRP234C, TYR102C, TYR209C, TYR295C, TYR594B
• B-D: ALA505B, ALA565D, ALA596B, ALA596D, ALA630B, ARG576B, ARG576D, ARG606B, ARG606D, ASN543D, ASN550D, ASN560D, ASN571D, ASN579B, ASN579D, ASN581B, ASN581D, ASN582B, ASN582D, ASN595B, ASN595D, ASN604B, ASN614D, ASN617D, ASN628D, ASP585B, ASP585D, ASP586B, ASP586D, ASP590B, ASP609B, ASP609D, ASP612B, ASP612D, GLN562D, GLU557D, GLU569D, GLU574B, GLU574D, GLU578B, GLU578D, GLU597B, GLU603B, GLU603D, GLU605B, GLU620B, GLU620D, GLU632B, GLY501B, GLY504B, GLY508B, GLY567D, GLY587B, GLY587D, GLY634B, HIS611D, ILE556D, ILE561D, ILE591B, ILE591D, ILE633B, LEU502B, LEU502D, LEU573B, LEU580B, LEU580D, LEU589B, LEU589D, LEU598B, LEU598D, LEU599B, LEU599D, LEU601B, LEU602B, LEU602D, LEU608B, LYS551D, LYS558D, LYS568D, LYS575B, LYS583B, LYS583D, LYS616B, LYS616D, LYS621D, LYS623B, LYS623D, LYS627B, LYS627D, LYS631B, MET559D, MET577B, MET577D, PHE503B, PHE503D, PHE509B, PHE563D, PHE570D, PHE588B, PHE588D, PHE610B, PHE610D, PHE638B, PRO660D, SER554D, SER613B, SER613D, SER624D, THR564D, THR593B, THR607B, THR607D, TRP592B, TRP592D, TYR594B, TYR594D, TYR619B, VAL555D, VAL566D, VAL584B, VAL584D, VAL600B, VAL600D
• B-E: ALA313E, ALA544B, ARG311E, ARG606B, ASN27E, ASN543B, ASN546B, ASN550B, ASN553B, ASN560B, ASN614B, ASP21E, GLU25E, GLU557B, GLU603B, GLY547B, ILE545B, ILE548B, LEU24E, LEU315E, LEU599B, LYS26E, LYS314E, LYS551B, LYS558B, PHE610B, SER312E, SER554B, THR22E, THR549B, THR607B, TRP592B, VAL23E, VAL28E, VAL552B, VAL555B
• B-F: ALA505F, ALA565B, ALA596B, ALA596F, ARG576B, ARG576F, ARG606B, ARG606F, ASN543B, ASN550B, ASN560B, ASN571B, ASN579B, ASN579F, ASN581B, ASN581F, ASN582B, ASN582F, ASN595B, ASN595F, ASN604F, ASN614B, ASN617B, ASN635F, ASP585B, ASP585F, ASP586B, ASP586F, ASP590B, ASP590F, ASP609B, ASP609F, ASP612B, ASP612F, GLN562B, GLU557B, GLU569B, GLU574B, GLU574F, GLU578B, GLU578F, GLU597F, GLU603B, GLU603F, GLU605F, GLU620B, GLU620F, GLU632F, GLY501F, GLY504F, GLY508F, GLY547B, GLY567B, GLY587B, GLY587F, GLY634F, HIS611B, ILE506F, ILE556B, ILE561B, ILE591B, ILE591F, ILE633F, LEU502B, LEU502F, LEU573F, LEU580B, LEU580F, LEU589B, LEU589F, LEU598B, LEU598F, LEU599B, LEU599F, LEU601F, LEU602B, LEU602F, LEU608F, LYS551B, LYS558B, LYS568B, LYS575F, LYS583B, LYS583F, LYS616B, LYS616F, LYS621B, LYS623B, LYS623F, LYS627B, LYS631F, MET559B, MET577B, MET577F, PHE503B, PHE503F, PHE509F, PHE563B, PHE570B, PHE570F, PHE588B, PHE588F, PHE610B, PHE610F, PRO660B, SER554B, SER613B, SER613F, SER624B, THR564B, THR593F, THR607B, THR607F, TRP592B, TRP592F, TYR594B, TYR594F, VAL555B, VAL566B, VAL584B, VAL584F, VAL600B, VAL600F
• C-D: ALA13C, ALA313C, ALA326C, ALA505D, ALA507D, ALA535D, ALA536D, ALA544D, ALA565D, ALA596D, ALA630D, ARG106C, ARG311C, ARG316C, ARG322C, ARG327C, ARG606D, ARG653D, ASN14C, ASN15C, ASN27C, ASN297C, ASN323C, ASN35C, ASN528D, ASN553D, ASN560D, ASN571D, ASN582D, ASN595D, ASN604D, ASN60C, ASN614D, ASN617D, ASN635D, ASN646D, ASN654D, ASP101C, ASP21C, ASP519D, ASP537D, ASP585D, ASP586D, ASP590D, ASP5C, ASP609D, ASP612D, ASP645D, ASP98C, CYS282C, CYS306C, CYS637D, CYS644D, CYS648D, CYS8C, GLN283C, GLN296C, GLN527D, GLN530D, GLN562D, GLN625D, GLU103C, GLU104C, GLU107C, GLU25C, GLU305C, GLU511D, GLU529D, GLU557D, GLU569D, GLU574D, GLU597D, GLU603D, GLU605D, GLU620D, GLU632D, GLU639D, GLU650D, GLU85C, GLY10C, GLY265C, GLY267C, GLY304C, GLY320C, GLY501D, GLY504D, GLY508D, GLY512D, GLY513D, GLY516D, GLY520D, GLY523D, GLY531D, GLY533D, GLY567D, GLY587D, GLY636D, HIS12C, HIS299C, HIS32C, HIS525D, HIS526D, HIS611D, HIS642D, ILE100C, ILE268C, ILE269C, ILE303C, ILE324C, ILE506D, ILE510D, ILE518D, ILE545D, ILE548D, ILE556D, ILE561D, ILE591D, ILE61C, ILE633D, ILE7C, ILE83C, ILE9C, LEU24C, LEU293C, LEU315C, LEU321C, LEU36C, LEU37C, LEU48C, LEU502D, LEU573D, LEU589D, LEU598D, LEU599D, LEU601D, LEU602D, LEU608D, LEU618D, LEU626D, LYS26C, LYS281C, LYS308C, LYS314C, LYS49C, LYS551D, LYS558D, LYS568D, LYS572D, LYS616D, LYS621D, LYS623D, LYS631D, LYS643D, MET317C, MET517D, MET559D, MET577D, MET649D, PHE264C, PHE509D, PHE563D, PHE570D, PHE588D, PHE610D, PHE638D, PHE640D, PHE99C, PRO285C, PRO294C, PRO300C, PRO307C, PRO325C, SER110C, SER111C, SER16C, SER266C, SER291C, SER292C, SER312C, SER33C, SER532D, SER554D, SER651D, SER81C, THR19C, THR22C, THR270C, THR284C, THR29C, THR302C, THR319C, THR31C, THR515D, THR541D, THR549D, THR564D, THR593D, THR607D, THR6C, TRP514D, TRP521D, TRP592D, TYR102C, TYR11C, TYR295C, TYR309C, TYR522D, TYR524D, TYR534D, TYR594D, TYR619D, TYR641D, TYR82C, VAL20C, VAL23C, VAL28C, VAL301C, VAL30C, VAL310C, VAL318C, VAL34C, VAL552D, VAL555D, VAL566D, VAL600D, VAL615D, VAL622D, VAL652D
• C-E: ALA218C, ALA227C, ARG211E, ARG212E, ARG220C, ARG224C, ARG229C, ASN187C, ASN199C, ASN208E, ASN210E, ASN231C, ASP241E, ASP98C, GLN226C, GLU216C, GLU219C, GLU246E, GLY228C, GLY240E, GLY97C, HIS184C, ILE100C, ILE217C, ILE243E, ILE244E, LEU237E, LYS163E, LYS165E, LYS222C, MET230C, PHE213E, PRO186C, PRO215C, PRO221C, PRO96C, SER167E, SER188C, SER203E, SER207E, THR206E, THR214C, THR214E, THR242E, TYR168E, TYR201E, TYR209E, TYR233C, VAL169E, VAL204E, VAL205E, VAL223C
• C-F: ALA313C, ALA544F, ARG311C, ARG606F, ASN27C, ASN543F, ASN546F, ASN550F, ASN553F, ASN560F, ASN614F, ASP21C, GLU25C, GLU557F, GLU603F, GLY547F, ILE545F, ILE548F, LEU24C, LEU315C, LEU599F, LYS26C, LYS314C, LYS551F, LYS558F, PHE610F, SER312C, SER554F, THR22C, THR549F, THR607F, TRP592F, VAL23C, VAL28C, VAL552F, VAL555F
• D-E: ARG106E, ARG211E, ARG262E, ARG576D, ASN208E, ASN210E, ASN571D, ASN579D, ASP101E, ASP590D, GLN108E, GLU103E, GLU104E, GLU107E, GLU574D, GLU578D, GLY587D, ILE100E, ILE591D, LEU105E, LEU109E, LEU236E, LEU237E, LEU573D, LEU580D, LYS238E, LYS308E, LYS572D, LYS575D, MET317E, MET577D, PHE570D, PRO294E, SER110E, SER111E, SER207E, THR206E, THR235E, TRP234E, TYR102E, TYR209E, TYR295E, TYR594D
• D-F: ALA505D, ALA565F, ALA596D, ALA596F, ARG576D, ARG576F, ARG606D, ARG606F, ASN543F, ASN550F, ASN560F, ASN571F, ASN579D, ASN579F, ASN581D, ASN581F, ASN582D, ASN582F, ASN595D, ASN595F, ASN604D, ASN614F, ASN617F, ASN628F, ASN635D, ASP585D, ASP585F, ASP586D, ASP586F, ASP590D, ASP590F, ASP609D, ASP609F, ASP612D, ASP612F, GLN562F, GLN625F, GLU557F, GLU569F, GLU574D, GLU574F, GLU578D, GLU578F, GLU597D, GLU603D, GLU603F, GLU605D, GLU620F, GLU632D, GLY501D, GLY504D, GLY508D, GLY547F, GLY567F, GLY587D, GLY587F, GLY634D, HIS611F, ILE556F, ILE561F, ILE591D, ILE591F, ILE633D, LEU502D, LEU502F, LEU573D, LEU580D, LEU580F, LEU589D, LEU589F, LEU598D, LEU599D, LEU599F, LEU601D, LEU602D, LEU602F, LEU608D, LYS551F, LYS558F, LYS568F, LYS575D, LYS583D, LYS583F, LYS616D, LYS616F, LYS621F, LYS623D, LYS623F, LYS627F, LYS631D, MET559F, MET577D, MET577F, PHE503D, PHE503F, PHE509D, PHE563F, PHE570D, PHE570F, PHE588D, PHE588F, PHE610D, PHE610F, SER554F, SER613D, SER613F, SER624F, THR564F, THR593D, THR607D, THR607F, TRP592D, TRP592F, TYR594D, TYR594F, TYR659F, VAL555F, VAL566F, VAL584D, VAL584F, VAL600D, VAL600F
• E-F: ALA13E, ALA313E, ALA326E, ALA505F, ALA507F, ALA535F, ALA536F, ALA544F, ALA565F, ALA596F, ALA630F, ARG106E, ARG311E, ARG316E, ARG322E, ARG327E, ARG606F, ARG653F, ASN14E, ASN15E, ASN27E, ASN297E, ASN323E, ASN35E, ASN528F, ASN553F, ASN560F, ASN571F, ASN582F, ASN595F, ASN604F, ASN60E, ASN614F, ASN617F, ASN635F, ASP101E, ASP21E, ASP519F, ASP537F, ASP585F, ASP586F, ASP590F, ASP5E, ASP609F, ASP612F, ASP645F, ASP98E, CYS282E, CYS306E, CYS637F, CYS644F, CYS648F, CYS8E, GLN283E, GLN296E, GLN527F, GLN530F, GLN562F, GLU103E, GLU104E, GLU107E, GLU25E, GLU305E, GLU511F, GLU529F, GLU557F, GLU569F, GLU574F, GLU597F, GLU603F, GLU605F, GLU620F, GLU639F, GLU650F, GLU85E, GLY10E, GLY265E, GLY267E, GLY304E, GLY320E, GLY501F, GLY508F, GLY512F, GLY513F, GLY516F, GLY520F, GLY523F, GLY533F, GLY567F, GLY587F, GLY634F, GLY636F, HIS12E, HIS299E, HIS32E, HIS525F, HIS526F, HIS611F, HIS642F, ILE100E, ILE268E, ILE269E, ILE303E, ILE324E, ILE506F, ILE510F, ILE518F, ILE545F, ILE548F, ILE556F, ILE561F, ILE591F, ILE61E, ILE633F, ILE7E, ILE83E, ILE9E, LEU24E, LEU293E, LEU315E, LEU321E, LEU36E, LEU37E, LEU48E, LEU502F, LEU573F, LEU589F, LEU598F, LEU599F, LEU601F, LEU602F, LEU608F, LEU618F, LEU626F, LYS26E, LYS281E, LYS308E, LYS314E, LYS49E, LYS551F, LYS558F, LYS568F, LYS572F, LYS616F, LYS621F, LYS623F, LYS631F, LYS643F, MET317E, MET517F, MET559F, MET577F, MET649F, PHE264E, PHE509F, PHE563F, PHE570F, PHE588F, PHE610F, PHE638F, PHE640F, PHE99E, PRO285E, PRO294E, PRO300E, PRO307E, PRO325E, SER110E, SER16E, SER266E, SER292E, SER312E, SER33E, SER554F, SER651F, SER81E, THR19E, THR22E, THR270E, THR284E, THR29E, THR302E, THR319E, THR31E, THR515F, THR541F, THR549F, THR564F, THR593F, THR607F, THR6E, TRP514F, TRP521F, TRP592F, TYR102E, TYR11E, TYR295E, TYR309E, TYR522F, TYR524F, TYR534F, TYR594F, TYR619F, TYR641F, TYR657F, TYR82E, VAL20E, VAL23E, VAL28E, VAL301E, VAL30E, VAL310E, VAL318E, VAL34E, VAL552F, VAL555F, VAL566F, VAL600F, VAL615F, VAL622F, VAL652F
• G-H: ALA13G, ALA313G, ALA326G, ALA505H, ALA507H, ALA535H, ALA536H, ALA544H, ALA565H, ALA596H, ALA630H, ARG106G, ARG311G, ARG316G, ARG322G, ARG327G, ARG606H, ARG653H, ASN14G, ASN15G, ASN27G, ASN297G, ASN323G, ASN35G, ASN528H, ASN553H, ASN560H, ASN571H, ASN582H, ASN595H, ASN604H, ASN60G, ASN614H, ASN617H, ASN629H, ASN635H, ASN646H, ASP101G, ASP21G, ASP519H, ASP537H, ASP585H, ASP586H, ASP590H, ASP5G, ASP609H, ASP612H, ASP645H, ASP98G, CYS282G, CYS306G, CYS637H, CYS644H, CYS648H, CYS8G, GLN283G, GLN296G, GLN527H, GLN530H, GLN562H, GLU103G, GLU104G, GLU107G, GLU25G, GLU305G, GLU511H, GLU529H, GLU557H, GLU569H, GLU574H, GLU578H, GLU597H, GLU603H, GLU605H, GLU620H, GLU632H, GLU639H, GLU650H, GLU85G, GLY10G, GLY265G, GLY267G, GLY304G, GLY320G, GLY501H, GLY508H, GLY512H, GLY513H, GLY516H, GLY520H, GLY523H, GLY531H, GLY533H, GLY567H, GLY587H, GLY634H, GLY636H, HIS12G, HIS299G, HIS32G, HIS525H, HIS526H, HIS611H, HIS642H, ILE100G, ILE268G, ILE269G, ILE303G, ILE324G, ILE506H, ILE510H, ILE518H, ILE545H, ILE548H, ILE556H, ILE561H, ILE591H, ILE61G, ILE633H, ILE7G, ILE83G, ILE9G, LEU24G, LEU293G, LEU315G, LEU321G, LEU36G, LEU37G, LEU48G, LEU502H, LEU573H, LEU589H, LEU598H, LEU599H, LEU601H, LEU602H, LEU608H, LEU618H, LEU626H, LYS26G, LYS281G, LYS308G, LYS314G, LYS49G, LYS551H, LYS558H, LYS568H, LYS572H, LYS616H, LYS621H, LYS623H, LYS631H, LYS643H, MET317G, MET517H, MET559H, MET577H, MET649H, PHE264G, PHE509H, PHE563H, PHE570H, PHE588H, PHE610H, PHE638H, PHE640H, PHE99G, PRO285G, PRO294G, PRO300G, PRO307G, PRO325G, SER110G, SER16G, SER266G, SER291G, SER292G, SER312G, SER33G, SER532H, SER540H, SER554H, SER651H, SER81G, THR19G, THR22G, THR270G, THR284G, THR29G, THR302G, THR319G, THR31G, THR515H, THR541H, THR549H, THR564H, THR593H, THR607H, THR6G, TRP514H, TRP521H, TRP592H, TYR102G, TYR11G, TYR295G, TYR309G, TYR522H, TYR524H, TYR534H, TYR594H, TYR619H, TYR641H, TYR82G, VAL20G, VAL23G, VAL28G, VAL301G, VAL30G, VAL310G, VAL318G, VAL34G, VAL552H, VAL555H, VAL566H, VAL600H, VAL615H, VAL622H, VAL652H
• G-I: ALA218G, ALA227G, ARG211I, ARG212I, ARG220G, ARG224G, ARG229G, ASN187G, ASN208I, ASN210I, ASN231G, ASP241I, ASP98G, GLU216G, GLU219G, GLU246I, GLY228G, GLY240I, GLY97G, HIS184G, ILE217G, ILE243I, ILE244I, ILE93G, LEU237I, LYS163I, LYS165I, LYS222G, MET230G, PHE213I, PRO186G, PRO215G, PRO221G, PRO96G, SER167I, SER188G, SER203I, SER207I, THR206I, THR214G, THR214I, THR242I, TYR168I, TYR201I, TYR209I, TYR233G, VAL169I, VAL204I, VAL205I, VAL223G
• G-J: ALA313G, ALA544J, ARG311G, ARG606J, ASN27G, ASN543J, ASN546J, ASN550J, ASN553J, ASN560J, ASN614J, ASP21G, GLU25G, GLU557J, GLU603J, GLY547J, ILE545J, ILE548J, LEU24G, LEU315G, LEU599J, LYS26G, LYS314G, LYS551J, LYS558J, PHE610J, SER312G, SER554J, THR22G, THR549J, THR607J, TRP592J, VAL23G, VAL28G, VAL552J, VAL555J
• G-K: ALA218K, ALA227K, ARG211G, ARG212G, ARG220K, ARG224K, ARG229K, ASN208G, ASN210G, ASN231K, ASP241G, ASP98K, GLN226K, GLU216K, GLU219K, GLU246G, GLY228K, GLY240G, GLY97K, HIS184K, ILE217K, ILE243G, ILE244G, LEU237G, LYS163G, LYS165G, LYS222K, LYS238G, MET230K, MET317G, PHE213G, PRO186K, PRO215K, PRO221K, PRO96K, SER167G, SER203G, SER207G, THR206G, THR214G, THR214K, THR242G, TYR168G, TYR201G, TYR209G, TYR233K, VAL169G, VAL204G, VAL205G, VAL223K, VAL23K
• G-L: ARG106G, ARG211G, ARG262G, ARG576L, ASN208G, ASN210G, ASN571L, ASN579L, ASP101G, ASP590L, GLN108G, GLU103G, GLU104G, GLU107G, GLU574L, GLU578L, GLY587L, ILE100G, ILE591L, LEU105G, LEU109G, LEU236G, LEU573L, LEU580L, LEU598L, LYS238G, LYS308G, LYS572L, LYS575L, MET317G, MET577L, PRO294G, SER110G, SER111G, SER207G, THR206G, THR235G, TRP234G, TYR102G, TYR209G, TYR295G, TYR594L
• H-I: ARG106I, ARG211I, ARG262I, ARG576H, ASN208I, ASN210I, ASN571H, ASN579H, ASP101I, ASP590H, GLN108I, GLU103I, GLU104I, GLU107I, GLU574H, GLU578H, GLY587H, ILE100I, ILE591H, LEU105I, LEU109I, LEU236I, LEU573H, LEU580H, LEU598H, LYS238I, LYS308I, LYS572H, LYS575H, MET577H, PRO294I, SER110I, SER111I, SER207I, THR206I, THR235I, TRP234I, TYR102I, TYR209I, TYR295I, TYR594H
• H-J: ALA505H, ALA565J, ALA596H, ALA596J, ALA630H, ARG576H, ARG576J, ARG606H, ARG606J, ASN543J, ASN550J, ASN560J, ASN571J, ASN579H, ASN579J, ASN581H, ASN581J, ASN582H, ASN582J, ASN595H, ASN595J, ASN604H, ASN614J, ASN617J, ASN628J, ASN635H, ASP585H, ASP585J, ASP586H, ASP586J, ASP590H, ASP609H, ASP609J, ASP612H, ASP612J, GLN562J, GLU557J, GLU569J, GLU574H, GLU574J, GLU578H, GLU578J, GLU597H, GLU603H, GLU603J, GLU605H, GLU620H, GLU620J, GLU632H, GLY501H, GLY504H, GLY508H, GLY547J, GLY567J, GLY587H, GLY587J, GLY634H, HIS611J, ILE556J, ILE561J, ILE591H, ILE591J, ILE633H, LEU502H, LEU502J, LEU573H, LEU580H, LEU580J, LEU589H, LEU589J, LEU598H, LEU599H, LEU599J, LEU601H, LEU602H, LEU602J, LEU608H, LYS551J, LYS558J, LYS568J, LYS575H, LYS583H, LYS583J, LYS616H, LYS616J, LYS621J, LYS623H, LYS623J, LYS627H, LYS627J, LYS631H, MET559J, MET577H, MET577J, PHE503H, PHE503J, PHE509H, PHE563J, PHE570H, PHE570J, PHE588H, PHE588J, PHE610H, PHE610J, PHE638H, PRO660J, SER554J, SER613H, SER613J, SER624J, THR564J, THR593H, THR607H, THR607J, TRP592H, TRP592J, TYR594H, TYR594J, TYR619H, VAL555J, VAL566J, VAL584H, VAL584J, VAL600H, VAL600J
• H-K: ALA313K, ALA544H, ARG311K, ARG322K, ARG606H, ASN27K, ASN543H, ASN546H, ASN550H, ASN553H, ASN560H, ASN614H, ASP21K, GLU25K, GLU557H, GLU603H, GLY547H, ILE545H, ILE548H, LEU24K, LEU315K, LEU599H, LYS26K, LYS314K, LYS551H, LYS558H, PHE610H, SER312K, SER554H, THR22K, THR549H, THR607H, TRP592H, VAL23K, VAL28K, VAL552H, VAL555H
• H-L: ALA505L, ALA507L, ALA565H, ALA596H, ALA596L, ARG576H, ARG576L, ARG606H, ARG606L, ASN550H, ASN560H, ASN571H, ASN579H, ASN579L, ASN581H, ASN581L, ASN582H, ASN582L, ASN595H, ASN595L, ASN604L, ASN614H, ASN617H, ASN635L, ASP585H, ASP585L, ASP586H, ASP586L, ASP590H, ASP590L, ASP609H, ASP609L, ASP612H, ASP612L, GLN562H, GLU511L, GLU557H, GLU569H, GLU574H, GLU574L, GLU578H, GLU578L, GLU597L, GLU603H, GLU603L, GLU605L, GLU620H, GLU632L, GLY501L, GLY504L, GLY508L, GLY547H, GLY567H, GLY587H, GLY587L, GLY634L, HIS611H, ILE506L, ILE556H, ILE561H, ILE591H, ILE591L, ILE633L, LEU502H, LEU502L, LEU573L, LEU580H, LEU580L, LEU589H, LEU589L, LEU598H, LEU598L, LEU599H, LEU599L, LEU601L, LEU602H, LEU602L, LEU608L, LYS551H, LYS551L, LYS558H, LYS568H, LYS575L, LYS583H, LYS583L, LYS616H, LYS616L, LYS621H, LYS623H, LYS623L, LYS627H, LYS631L, MET559H, MET577H, MET577L, PHE503H, PHE503L, PHE509L, PHE563H, PHE570H, PHE570L, PHE588H, PHE588L, PHE610H, PRO660H, SER554H, SER613H, SER613L, SER624H, THR564H, THR593L, THR607H, THR607L, TRP592H, TRP592L, TYR594H, TYR594L, VAL555H, VAL566H, VAL584H, VAL584L, VAL600H, VAL600L
• I-J: ALA13I, ALA313I, ALA326I, ALA505J, ALA507J, ALA535J, ALA536J, ALA544J, ALA565J, ALA596J, ALA630J, ARG106I, ARG311I, ARG316I, ARG322I, ARG327I, ARG606J, ARG653J, ASN14I, ASN15I, ASN27I, ASN297I, ASN323I, ASN35I, ASN528J, ASN553J, ASN560J, ASN571J, ASN582J, ASN595J, ASN604J, ASN60I, ASN614J, ASN617J, ASN635J, ASN646J, ASP101I, ASP21I, ASP519J, ASP537J, ASP585J, ASP586J, ASP590J, ASP5I, ASP609J, ASP612J, ASP645J, ASP98I, CYS282I, CYS306I, CYS637J, CYS644J, CYS648J, CYS8I, GLN283I, GLN296I, GLN527J, GLN530J, GLN562J, GLN625J, GLU103I, GLU104I, GLU107I, GLU25I, GLU305I, GLU511J, GLU529J, GLU557J, GLU569J, GLU574J, GLU597J, GLU603J, GLU605J, GLU620J, GLU632J, GLU639J, GLU650J, GLU85I, GLY10I, GLY265I, GLY267I, GLY304I, GLY320I, GLY501J, GLY508J, GLY512J, GLY513J, GLY516J, GLY520J, GLY523J, GLY531J, GLY533J, GLY567J, GLY587J, GLY636J, HIS12I, HIS299I, HIS32I, HIS525J, HIS526J, HIS611J, HIS642J, ILE100I, ILE268I, ILE269I, ILE303I, ILE324I, ILE506J, ILE510J, ILE518J, ILE545J, ILE548J, ILE556J, ILE561J, ILE591J, ILE61I, ILE633J, ILE7I, ILE83I, ILE9I, LEU24I, LEU293I, LEU315I, LEU321I, LEU36I, LEU37I, LEU48I, LEU502J, LEU573J, LEU589J, LEU598J, LEU599J, LEU601J, LEU602J, LEU608J, LEU618J, LEU626J, LYS26I, LYS281I, LYS308I, LYS314I, LYS49I, LYS551J, LYS558J, LYS568J, LYS572J, LYS616J, LYS621J, LYS623J, LYS631J, LYS643J, MET317I, MET517J, MET559J, MET577J, MET649J, PHE264I, PHE509J, PHE563J, PHE570J, PHE588J, PHE610J, PHE638J, PHE640J, PHE99I, PRO285I, PRO294I, PRO300I, PRO307I, PRO325I, SER110I, SER16I, SER266I, SER291I, SER292I, SER312I, SER33I, SER532J, SER554J, SER651J, SER81I, THR19I, THR22I, THR270I, THR284I, THR29I, THR302I, THR319I, THR31I, THR515J, THR541J, THR549J, THR564J, THR593J, THR607J, THR6I, TRP514J, TRP521J, TRP592J, TYR102I, TYR11I, TYR295I, TYR309I, TYR522J, TYR524J, TYR534J, TYR594J, TYR619J, TYR641J, TYR82I, VAL20I, VAL23I, VAL28I, VAL301I, VAL30I, VAL310I, VAL318I, VAL34I, VAL552J, VAL555J, VAL566J, VAL600J, VAL615J, VAL622J, VAL652J
• I-K: ALA218I, ALA227I, ARG211K, ARG212K, ARG220I, ARG224I, ARG229I, ASN199I, ASN208K, ASN210K, ASN231I, ASP241K, ASP98I, GLN226I, GLU216I, GLU219I, GLU246K, GLY228I, GLY240K, GLY97I, HIS184I, ILE217I, ILE243K, ILE244K, LEU237K, LYS163K, LYS165K, LYS222I, MET230I, PHE213K, PRO186I, PRO215I, PRO221I, PRO96I, SER167K, SER203K, SER207K, THR206K, THR214I, THR214K, THR242K, TYR168K, TYR201K, TYR209K, TYR233I, VAL169K, VAL202K, VAL204K, VAL205K, VAL223I
• I-L: ALA313I, ALA544L, ARG311I, ARG606L, ASN27I, ASN543L, ASN546L, ASN550L, ASN553L, ASN560L, ASN614L, ASP21I, GLU25I, GLU557L, GLU603L, GLY547L, ILE545L, ILE548L, LEU24I, LEU315I, LEU599L, LYS26I, LYS314I, LYS551L, LYS558L, PHE610L, SER312I, SER554L, THR22I, THR549L, THR607L, TRP592L, VAL23I, VAL28I, VAL552L, VAL555L
• J-K: ARG106K, ARG211K, ARG262K, ARG576J, ASN208K, ASN210K, ASN571J, ASN579J, ASP101K, ASP590J, GLN108K, GLU103K, GLU104K, GLU107K, GLU574J, GLU578J, GLY587J, ILE100K, ILE591J, LEU105K, LEU109K, LEU236K, LEU573J, LEU580J, LYS238K, LYS308K, LYS572J, LYS575J, MET317K, MET577J, PRO294K, SER110K, SER111K, SER207K, THR206K, THR235K, TRP234K, TYR102K, TYR209K, TYR295K, TYR594J
• J-L: ALA505J, ALA565L, ALA596J, ALA596L, ARG576J, ARG576L, ARG606J, ARG606L, ASN543L, ASN550L, ASN560L, ASN571L, ASN579J, ASN579L, ASN581J, ASN581L, ASN582J, ASN582L, ASN595J, ASN595L, ASN604J, ASN614L, ASN617L, ASN628L, ASN635J, ASP585J, ASP585L, ASP586J, ASP586L, ASP590J, ASP609J, ASP609L, ASP612J, ASP612L, GLN562L, GLN625L, GLU557L, GLU569L, GLU574J, GLU574L, GLU578J, GLU578L, GLU597J, GLU603J, GLU603L, GLU605J, GLU620L, GLU632J, GLY501J, GLY504J, GLY508J, GLY547L, GLY567L, GLY587J, GLY587L, GLY634J, HIS611L, ILE556L, ILE561L, ILE591J, ILE591L, ILE633J, LEU502J, LEU502L, LEU573J, LEU580J, LEU580L, LEU589J, LEU589L, LEU598J, LEU598L, LEU599J, LEU599L, LEU601J, LEU602J, LEU602L, LEU608J, LYS551L, LYS558L, LYS568J, LYS568L, LYS575J, LYS583J, LYS583L, LYS616J, LYS616L, LYS621L, LYS623J, LYS623L, LYS627L, LYS631J, MET559L, MET577J, MET577L, PHE503J, PHE503L, PHE509J, PHE563L, PHE570J, PHE570L, PHE588J, PHE588L, PHE610J, PHE610L, SER554L, SER613J, SER613L, SER624L, THR564L, THR593J, THR607J, THR607L, TRP592J, TRP592L, TYR594J, TYR594L, TYR659L, VAL555L, VAL566L, VAL584J, VAL584L, VAL600J, VAL600L
• K-L: ALA13K, ALA313K, ALA326K, ALA505L, ALA507L, ALA535L, ALA536L, ALA544L, ALA565L, ALA596L, ALA630L, ARG106K, ARG311K, ARG316K, ARG322K, ARG327K, ARG606L, ARG653L, ASN14K, ASN15K, ASN27K, ASN297K, ASN323K, ASN35K, ASN528L, ASN553L, ASN560L, ASN571L, ASN582L, ASN595L, ASN604L, ASN60K, ASN614L, ASN617L, ASN635L, ASP101K, ASP21K, ASP519L, ASP537L, ASP585L, ASP586L, ASP590L, ASP5K, ASP609L, ASP612L, ASP645L, ASP98K, CYS282K, CYS306K, CYS637L, CYS644L, CYS648L, CYS8K, GLN283K, GLN296K, GLN527L, GLN530L, GLN562L, GLU103K, GLU104K, GLU107K, GLU25K, GLU305K, GLU511L, GLU529L, GLU557L, GLU569L, GLU574L, GLU597L, GLU603L, GLU605L, GLU620L, GLU639L, GLU650L, GLU85K, GLY10K, GLY265K, GLY267K, GLY304K, GLY320K, GLY501L, GLY504L, GLY508L, GLY512L, GLY513L, GLY516L, GLY520L, GLY523L, GLY531L, GLY533L, GLY567L, GLY587L, GLY634L, GLY636L, HIS12K, HIS299K, HIS32K, HIS525L, HIS526L, HIS611L, HIS642L, ILE100K, ILE268K, ILE269K, ILE303K, ILE324K, ILE506L, ILE510L, ILE518L, ILE545L, ILE548L, ILE556L, ILE561L, ILE591L, ILE61K, ILE633L, ILE7K, ILE83K, ILE9K, LEU24K, LEU293K, LEU315K, LEU321K, LEU36K, LEU37K, LEU48K, LEU502L, LEU573L, LEU589L, LEU598L, LEU599L, LEU601L, LEU602L, LEU608L, LEU618L, LEU626L, LYS26K, LYS281K, LYS308K, LYS314K, LYS49K, LYS551L, LYS558L, LYS568L, LYS572L, LYS616L, LYS621L, LYS623L, LYS631L, LYS643L, MET317K, MET517L, MET559L, MET577L, MET649L, PHE264K, PHE509L, PHE563L, PHE570L, PHE588L, PHE610L, PHE638L, PHE640L, PHE99K, PRO285K, PRO294K, PRO300K, PRO307K, PRO325K, SER110K, SER16K, SER266K, SER291K, SER292K, SER312K, SER33K, SER532L, SER554L, SER651L, SER81K, THR19K, THR22K, THR270K, THR284K, THR29K, THR302K, THR319K, THR31K, THR515L, THR541L, THR549L, THR564L, THR593L, THR607L, THR6K, TRP514L, TRP521L, TRP592L, TYR102K, TYR11K, TYR295K, TYR309K, TYR522L, TYR524L, TYR534L, TYR594L, TYR619L, TYR641L, TYR657L, TYR82K, VAL20K, VAL23K, VAL28K, VAL301K, VAL30K, VAL310K, VAL318K, VAL34K, VAL552L, VAL555L, VAL566L, VAL600L, VAL615L, VAL622L, VAL652L