1RJ8

the crystal structure of tnf family member eda-a2

• Total interactions analyzed: 15
• Total true interactions: 9
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 100
  • Norm. En. per Res.: -3.6229
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-47.2826	-9.751	-273.166	-330.1997	99	17	7	11307	0	10	8
A-D	-85.765	15.9582	-292.486	-362.2928	100	10	7	12033	0	10	10
A-E	-15.1221	8.388	-107.973	-114.7071	59	2	3	4426	4	29	30
A-G	-6.5069	-27.8117	-28.2198	-62.5384	28	4	1	1469	3	9	7
B-D	-53.7018	5.0157	-300.95	-349.6362	104	14	7	11934	0	13	9
D-E	0.0	-26.8196	-50.6698	-77.4894	39	3	1	2241	2	8	9
E-F	-48.2433	-13.273	-251.562	-313.0783	101	18	8	10580	0	11	9
E-G	-51.9708	32.4497	-256.862	-276.3831	98	16	7	10895	0	11	9
F-G	-44.4672	-15.0488	-296.207	-355.723	105	18	8	12192	0	11	9

Interface residues

• A-B: ALA249A, ALA318B, ALA349A, ALA349B, ALA382A, ALA388B, ARG334A, ARG334B, ARG384A, ARG384B, ASN280A, ASN342A, ASN342B, ASN344A, ASN344B, ASP316B, CYS332A, CYS332B, CYS346A, CYS346B, CYS352B, GLN254A, GLN306A, GLN331B, GLU321B, GLU337A, GLU337B, GLU387B, GLY339A, GLY339B, GLY350B, GLY381A, GLY386B, HIS252A, HIS376A, ILE277A, ILE303B, ILE312A, ILE336A, ILE336B, ILE383A, ILE383B, LEU253A, LEU330B, LEU353B, LEU354B, LEU385A, LEU385B, LYS282A, LYS327B, LYS340A, LYS375A, MET279A, PHE302A, PHE302B, PHE314A, PHE314B, PHE317B, PHE329B, PHE379A, PHE380A, PRO248A, PRO248B, PRO281A, PRO328B, PRO389B, SER305A, SER319B, SER335B, SER374A, THR278A, THR300B, THR315B, THR333B, THR338A, THR338B, THR341A, THR345A, THR345B, THR348A, THR348B, THR377A, THR378A, TYR301B, TYR304A, TYR304B, TYR310A, TYR311A, TYR311B, TYR320B, TYR343A, TYR347A, TYR347B, VAL250A, VAL251A, VAL307A, VAL322B, VAL323B, VAL351B
• A-D: ALA249D, ALA318A, ALA349A, ALA349D, ALA382D, ALA388A, ARG334A, ARG334D, ARG384A, ARG384D, ASN280D, ASN313D, ASN342A, ASN342D, ASN344A, ASN344D, ASN372D, ASP316A, CYS332A, CYS332D, CYS346A, CYS346D, CYS352A, GLN254D, GLN306D, GLN331A, GLU321A, GLU337A, GLU337D, GLU387A, GLY339A, GLY339D, GLY350A, GLY381D, GLY386A, HIS252D, HIS376D, ILE277D, ILE303A, ILE303D, ILE312D, ILE336A, ILE336D, ILE383A, ILE383D, LEU253D, LEU330A, LEU353A, LEU385A, LEU385D, LYS282D, LYS327A, LYS340A, LYS340D, LYS375D, MET279D, PHE284D, PHE302A, PHE302D, PHE314A, PHE314D, PHE317A, PHE329A, PHE379D, PHE380D, PRO248A, PRO248D, PRO281D, PRO328A, PRO389A, SER305D, SER319A, SER335A, SER335D, SER374D, THR278D, THR300A, THR333A, THR338A, THR341D, THR345A, THR345D, THR348A, THR348D, THR377D, THR378D, TYR301A, TYR304A, TYR304D, TYR310D, TYR311A, TYR311D, TYR320A, TYR343D, TYR347A, TYR347D, VAL250D, VAL251D, VAL322A, VAL351A
• A-E: ALA318A, ALA318E, ALA367A, ALA367E, ARG334E, ASN264A, ASN264E, ASP265A, ASP316A, ASP316E, ASP325A, ASP325E, ASP368A, ASP368E, GLN331A, GLN331E, GLU321A, GLU321E, GLU326A, GLU326E, GLU337A, GLY268A, GLY268E, GLY269E, HIS366A, HIS366E, ILE369A, ILE369E, LYS263A, LYS263E, LYS327A, LYS327E, LYS363A, LYS363E, MET364A, MET364E, PHE317A, PHE317E, PHE329A, PHE329E, PRO328A, PRO328E, SER319A, SER319E, SER335A, SER335E, THR315A, THR315E, THR333A, THR333E, THR338E, VAL262A, VAL262E, VAL323A, VAL323E, VAL324A, VAL324E, VAL365A, VAL365E
• A-G: ALA259G, ASN264A, ASN344G, ASN372G, ASP265A, ASP325A, ASP368A, GLN261A, GLU292A, GLU326A, GLY257G, GLY268A, GLY269A, HIS366A, HIS376G, ILE312G, LEU266A, LYS263A, LYS363A, LYS375G, SER258G, SER267A, SER374G, THR341G, THR377G, TYR310G, TYR343G, VAL262A
• B-D: ALA249B, ALA318D, ALA349B, ALA349D, ALA382B, ALA388D, ARG334B, ARG334D, ARG384B, ARG384D, ASN280B, ASN342B, ASN342D, ASN344B, ASN344D, ASN372B, ASP316D, CYS332B, CYS332D, CYS346B, CYS346D, CYS352D, GLN254B, GLN306B, GLN331D, GLU321D, GLU337B, GLU337D, GLU387D, GLY299D, GLY339B, GLY350D, GLY381B, GLY386D, HIS252B, HIS376B, ILE277B, ILE303B, ILE303D, ILE312B, ILE336B, ILE336D, ILE383B, ILE383D, LEU253B, LEU330D, LEU353D, LEU354D, LEU385B, LEU385D, LYS282B, LYS327D, LYS340B, LYS340D, LYS375B, MET279B, PHE284B, PHE302B, PHE302D, PHE314B, PHE314D, PHE317D, PHE329D, PHE379B, PHE380B, PRO248B, PRO248D, PRO281B, PRO328D, PRO389D, SER305B, SER305D, SER319D, SER335D, SER374B, THR278B, THR300D, THR333D, THR338B, THR338D, THR341B, THR341D, THR345B, THR345D, THR348B, THR348D, THR377B, THR378B, TYR301D, TYR304B, TYR304D, TYR310B, TYR311B, TYR311D, TYR320D, TYR343B, TYR347B, TYR347D, VAL250B, VAL251B, VAL307B, VAL322D, VAL323D, VAL351D
• D-E: ALA259D, ALA367E, ARG289E, ASN264E, ASN272E, ASN313D, ASN372D, ASP265E, ASP325E, ASP368E, GLN254D, GLN256D, GLN261D, GLN261E, GLU292E, GLU326E, GLY255D, GLY257D, GLY268E, GLY269E, HIS376D, ILE277D, ILE312D, LEU266E, LYS263E, LYS363E, LYS375D, MET373D, SER258D, SER267E, SER290E, SER370D, SER374D, THR341D, THR377D, TYR310D, TYR343D, VAL262E, VAL270E
• E-F: ALA249E, ALA318F, ALA349E, ALA349F, ALA382E, ALA388F, ARG334E, ARG334F, ARG384E, ARG384F, ASN280E, ASN342E, ASN342F, ASN344E, ASN344F, ASN372E, ASP316F, CYS332E, CYS332F, CYS346E, CYS346F, CYS352F, GLN254E, GLN306E, GLN331F, GLU321F, GLU337E, GLU337F, GLU387F, GLY299F, GLY339F, GLY350F, GLY381E, GLY386F, HIS252E, HIS376E, ILE277E, ILE303E, ILE303F, ILE312E, ILE336E, ILE336F, ILE383E, ILE383F, LEU253E, LEU330F, LEU353F, LEU385E, LEU385F, LYS282E, LYS327F, LYS340E, LYS375E, MET279E, PHE284E, PHE302E, PHE302F, PHE314E, PHE314F, PHE317F, PHE329F, PHE379E, PHE380E, PRO248E, PRO248F, PRO281E, PRO328F, PRO389F, SER305E, SER305F, SER319F, SER335E, SER335F, SER374E, THR278E, THR300F, THR333F, THR338F, THR341E, THR345E, THR345F, THR348E, THR348F, THR377E, THR378E, TYR301F, TYR304E, TYR304F, TYR310E, TYR311E, TYR311F, TYR320F, TYR343E, TYR347E, TYR347F, VAL250E, VAL251E, VAL307E, VAL322F, VAL323F, VAL351F
• E-G: ALA249G, ALA318E, ALA349E, ALA349G, ALA382G, ALA388E, ARG334E, ARG334G, ARG384E, ARG384G, ASN280G, ASN342E, ASN342G, ASN344E, ASN344G, ASN372G, ASP316E, CYS332E, CYS332G, CYS346E, CYS346G, CYS352E, GLN254G, GLN306G, GLN331E, GLU321E, GLU337E, GLU337G, GLU387E, GLY350E, GLY381G, GLY386E, HIS252G, HIS366E, HIS376G, ILE277G, ILE303E, ILE303G, ILE312G, ILE336E, ILE336G, ILE383E, ILE383G, LEU253G, LEU330E, LEU353E, LEU385E, LEU385G, LYS282G, LYS327E, LYS340E, LYS340G, LYS375G, MET279G, PHE284G, PHE302E, PHE302G, PHE314E, PHE314G, PHE317E, PHE329E, PHE379G, PHE380G, PRO248E, PRO248G, PRO281G, PRO328E, PRO389E, SER305G, SER319E, SER335E, SER374G, THR278G, THR300E, THR333E, THR338E, THR341G, THR345E, THR345G, THR348E, THR348G, THR377G, THR378G, TYR301E, TYR304E, TYR304G, TYR310G, TYR311E, TYR311G, TYR320E, TYR343G, TYR347E, TYR347G, VAL250G, VAL251G, VAL307G, VAL322E, VAL351E
• F-G: ALA249F, ALA318G, ALA349F, ALA349G, ALA382F, ALA388G, ARG334F, ARG334G, ARG384F, ARG384G, ASN280F, ASN342F, ASN342G, ASN344F, ASN344G, ASN372F, ASP316G, CYS332F, CYS332G, CYS346F, CYS346G, CYS352G, GLN254F, GLN306F, GLN331G, GLU321G, GLU337F, GLU337G, GLU387G, GLY299G, GLY339F, GLY350G, GLY381F, GLY386G, HIS252F, HIS366G, HIS376F, ILE277F, ILE303F, ILE303G, ILE312F, ILE336F, ILE336G, ILE383F, ILE383G, LEU253F, LEU330G, LEU353G, LEU385F, LEU385G, LYS282F, LYS327G, LYS340F, LYS340G, LYS375F, MET279F, PHE284F, PHE302F, PHE302G, PHE314F, PHE314G, PHE317G, PHE329G, PHE379F, PHE380F, PRO248F, PRO248G, PRO281F, PRO328G, PRO389G, SER305F, SER319G, SER335G, SER374F, THR278F, THR300G, THR315G, THR333G, THR338F, THR338G, THR341F, THR341G, THR345F, THR345G, THR348F, THR348G, THR377F, THR378F, TYR301G, TYR304F, TYR304G, TYR310F, TYR311F, TYR311G, TYR320G, TYR343F, TYR343G, TYR347F, TYR347G, VAL250F, VAL251F, VAL307F, VAL322G, VAL323G, VAL351G