1RJ7

crystal structure of eda-a1

• Total interactions analyzed: 66
• Total true interactions: 21
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 92
  • Norm. En. per Res.: -3.1242
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-38.5776	9.9326	-249.145	-277.79	98	18	7	10271	1	11	11
A-D	-60.8977	44.624	-249.779	-266.0527	94	21	7	10552	0	13	11
A-E	-7.5015	-32.7139	-101.312	-141.5274	53	7	1	4504	5	22	26
A-G	-34.5845	-37.2794	-25.8309	-97.6948	36	5	0	1441	2	12	10
B-D	-54.4379	11.8443	-244.83	-287.4235	92	18	6	10044	0	10	10
D-E	-9.2649	-26.5552	-8.5897	-44.4098	22	1	0	618	3	7	8
E-F	-58.5414	60.4558	-246.138	-244.2235	96	14	7	10130	0	14	12
E-G	-61.8668	12.9066	-247.434	-296.3942	98	21	9	10593	1	11	10
F-G	-53.0388	20.9996	-255.105	-287.1442	95	16	7	10354	0	12	12
F-K	0.0	0.0	-0.0637	-0.0637	3	0	0	14	0	0	0
F-M	-30.1276	-4.5305	-121.809	-156.4671	62	8	1	4664	8	13	14
G-M	0.0	4.5685	-8.9852	-4.4168	16	0	0	454	0	3	5
H-I	-50.991	39.6758	-239.066	-250.3812	94	19	7	10365	1	13	11
H-J	-70.0008	25.5982	-224.267	-268.6696	87	14	7	8998	0	11	11
H-L	0.0	-15.4157	-1.7545	-17.1701	11	0	0	116	1	4	6
I-J	-52.3257	36.4003	-258.507	-274.4323	94	12	7	10366	0	12	12
I-K	0.0	-17.1456	-15.1429	-32.2885	35	0	0	1126	3	11	10
I-L	-12.615	-12.8433	-86.7412	-112.1995	51	2	1	3729	0	22	26
K-L	-38.3038	43.545	-249.233	-243.9918	92	14	7	10265	0	12	11
K-M	-72.8505	31.2663	-245.963	-287.5472	97	15	6	10386	0	12	11
L-M	-48.7877	28.9919	-242.655	-262.4508	99	15	8	9904	0	12	11

Interface residues

• A-B: ALA249A, ALA318B, ALA349A, ALA349B, ALA382A, ALA388B, ALA390B, ARG334A, ARG334B, ARG384A, ARG384B, ASN280A, ASN342A, ASN344A, ASN344B, ASN372A, ASP316B, CYS332B, CYS346A, CYS346B, CYS352B, GLN247A, GLN254A, GLN306A, GLN331B, GLU308A, GLU321B, GLU337A, GLU337B, GLU387B, GLY350B, GLY381A, GLY386B, HIS252A, HIS376A, ILE277A, ILE303A, ILE303B, ILE336A, ILE336B, ILE383A, ILE383B, LEU253A, LEU330B, LEU353B, LEU354B, LEU385A, LEU385B, LYS282A, LYS327B, LYS340A, LYS375A, MET279A, PHE284A, PHE302A, PHE302B, PHE314B, PHE317B, PHE329B, PHE379A, PHE380A, PRO248A, PRO248B, PRO281A, PRO328B, PRO389B, SER305A, SER305B, SER319B, SER335A, SER335B, SER374A, THR278A, THR300B, THR315B, THR333B, THR338B, THR341A, THR345A, THR345B, THR348A, THR348B, THR377A, THR378A, TYR301B, TYR304A, TYR304B, TYR310A, TYR320B, TYR343A, TYR347A, TYR347B, VAL250A, VAL251A, VAL307A, VAL309A, VAL322B, VAL351B
• A-D: ALA249D, ALA318A, ALA349A, ALA349D, ALA382D, ALA388A, ALA390A, ARG334A, ARG334D, ARG384A, ARG384D, ASN280D, ASN342D, ASN344A, ASN344D, ASN372D, ASP316A, CYS332A, CYS346A, CYS346D, CYS352A, GLN247D, GLN254D, GLN306D, GLN331A, GLU308D, GLU321A, GLU337A, GLU337D, GLU387A, GLY299A, GLY350A, GLY381D, GLY386A, HIS252D, HIS376D, ILE277D, ILE303A, ILE303D, ILE336A, ILE336D, ILE383A, ILE383D, LEU253D, LEU330A, LEU353A, LEU385A, LEU385D, LYS282D, LYS327A, LYS340D, LYS375D, MET279D, PHE284D, PHE302A, PHE302D, PHE317A, PHE329A, PHE379D, PHE380D, PRO248A, PRO248D, PRO281D, PRO328A, PRO389A, SER305D, SER319A, SER335A, SER335D, SER374D, THR278D, THR300A, THR333A, THR341D, THR345A, THR345D, THR348A, THR348D, THR377D, THR378D, TYR301A, TYR304A, TYR304D, TYR310D, TYR320A, TYR343D, TYR347A, TYR347D, VAL250D, VAL251D, VAL307D, VAL309D, VAL322A, VAL351A
• A-E: ALA318E, ALA367A, ALA367E, ASN313A, ASN313E, ASP316A, ASP316E, ASP325A, ASP325E, ASP368A, ASP368E, GLN331A, GLN331E, GLU321A, GLU321E, GLU326A, GLU326E, GLY268A, GLY268E, HIS366A, HIS366E, ILE312A, ILE336E, LYS263A, LYS263E, LYS327A, LYS327E, LYS363A, LYS363E, PHE314A, PHE314E, PHE317A, PHE317E, PHE329A, PHE329E, PRO328A, PRO328E, SER267A, SER319A, SER319E, SER335A, SER335E, THR315A, THR315E, THR333E, THR338A, THR338E, VAL323A, VAL323E, VAL324A, VAL324E, VAL365A, VAL365E
• A-G: ALA259G, ARG289A, ASN264A, ASN342G, ASN372G, ASP265A, ASP273G, ASP325A, GLN254G, GLN256G, GLU292A, GLU308G, GLU326A, GLY257G, GLY268A, GLY269A, HIS366A, HIS376G, ILE260G, ILE277G, LEU266A, LYS263A, LYS340G, LYS359A, LYS363A, LYS375G, MET373G, SER258G, SER267A, SER290A, SER374G, THR341G, THR377G, TYR310G, TYR343G, VAL262A
• B-D: ALA249B, ALA318D, ALA349B, ALA349D, ALA382B, ALA388D, ALA390D, ARG334B, ARG334D, ARG384B, ARG384D, ASN280B, ASN342B, ASN344B, ASN344D, ASN372B, ASP316D, CYS332D, CYS346B, CYS346D, CYS352D, GLN247B, GLN247D, GLN254B, GLN306B, GLN331D, GLU308B, GLU321D, GLU337B, GLU337D, GLU387D, GLY350D, GLY381B, GLY386D, HIS252B, HIS376B, ILE277B, ILE303B, ILE303D, ILE336B, ILE336D, ILE383B, ILE383D, LEU253B, LEU330D, LEU353D, LEU354D, LEU385B, LEU385D, LYS282B, LYS327D, LYS340B, LYS375B, MET279B, PHE302B, PHE302D, PHE317D, PHE329D, PHE379B, PRO248B, PRO248D, PRO281B, PRO328D, PRO389D, SER305B, SER319D, SER335B, SER335D, SER374B, THR278B, THR300D, THR333D, THR341B, THR345B, THR348B, THR348D, THR377B, THR378B, TYR301D, TYR304B, TYR304D, TYR310B, TYR320D, TYR343B, TYR347B, TYR347D, VAL250B, VAL251B, VAL307B, VAL309B, VAL322D, VAL351D
• D-E: ALA259D, ARG289E, ASN264E, ASN342D, ASN372D, ASP325E, GLN256D, GLU326E, GLY257D, GLY268E, HIS366E, HIS376D, LEU266E, LYS263E, LYS340D, LYS363E, LYS375D, SER258D, SER267E, SER374D, THR341D, TYR343D
• E-F: ALA249E, ALA318F, ALA349E, ALA349F, ALA382E, ALA388F, ALA390F, ARG334E, ARG334F, ARG384E, ARG384F, ASN280E, ASN342E, ASN344E, ASN344F, ASN372E, ASP316F, CYS332F, CYS346E, CYS346F, CYS352F, GLN247E, GLN247F, GLN254E, GLN306E, GLN331F, GLU245E, GLU308E, GLU321F, GLU337E, GLU337F, GLU387F, GLY350F, GLY381E, GLY386F, HIS252E, HIS376E, ILE277E, ILE303E, ILE303F, ILE336E, ILE336F, ILE383E, ILE383F, LEU253E, LEU330F, LEU353F, LEU385E, LEU385F, LYS282E, LYS327F, LYS340E, LYS375E, MET279E, PHE284E, PHE302E, PHE302F, PHE317F, PHE329F, PHE379E, PHE380E, PRO248E, PRO248F, PRO281E, PRO328F, PRO389F, SER305E, SER319F, SER335E, SER335F, SER374E, THR278E, THR300F, THR333E, THR333F, THR341E, THR345E, THR345F, THR348E, THR348F, THR377E, THR378E, TYR301F, TYR304E, TYR304F, TYR310E, TYR320F, TYR343E, TYR347E, TYR347F, VAL250E, VAL251E, VAL309E, VAL322F, VAL323F, VAL351F
• E-G: ALA249G, ALA318E, ALA349E, ALA349G, ALA382G, ALA388E, ALA390E, ARG334E, ARG334G, ARG384E, ARG384G, ASN246E, ASN280G, ASN342G, ASN344E, ASN344G, ASN372G, ASP316E, CYS332E, CYS346E, CYS346G, CYS352E, GLN247G, GLN254G, GLN306G, GLN331E, GLU245E, GLU308G, GLU321E, GLU337E, GLU337G, GLU387E, GLY299E, GLY350E, GLY381G, GLY386E, HIS252G, HIS376G, ILE277G, ILE303E, ILE303G, ILE336E, ILE336G, ILE383E, ILE383G, LEU253G, LEU330E, LEU353E, LEU385E, LEU385G, LYS282G, LYS327E, LYS340G, LYS375G, MET279G, PHE284G, PHE302E, PHE302G, PHE317E, PHE329E, PHE379G, PHE380G, PRO248E, PRO248G, PRO281G, PRO328E, PRO389E, SER305E, SER305G, SER319E, SER335E, SER335G, SER374G, THR278G, THR300E, THR315E, THR333E, THR338E, THR341G, THR345G, THR348E, THR348G, THR377G, THR378G, TYR301E, TYR304E, TYR304G, TYR310G, TYR320E, TYR343G, TYR347E, TYR347G, VAL250G, VAL251G, VAL307G, VAL309G, VAL322E, VAL351E
• F-G: ALA249F, ALA318G, ALA349F, ALA349G, ALA382F, ALA388G, ALA390G, ARG334F, ARG334G, ARG384F, ARG384G, ASN280F, ASN342F, ASN344F, ASN344G, ASN372F, ASP316G, CYS332G, CYS346F, CYS346G, CYS352G, GLN247F, GLN247G, GLN254F, GLN306F, GLN331G, GLU308F, GLU321G, GLU337F, GLU337G, GLU387G, GLY350G, GLY381F, GLY386G, HIS252F, HIS376F, ILE277F, ILE303F, ILE303G, ILE336F, ILE336G, ILE383F, ILE383G, LEU253F, LEU330G, LEU353G, LEU385F, LEU385G, LYS282F, LYS327G, LYS340F, LYS375F, MET279F, PHE284F, PHE302F, PHE302G, PHE317G, PHE329G, PHE379F, PHE380F, PRO248F, PRO248G, PRO281F, PRO328G, PRO389G, SER305F, SER319G, SER335F, SER335G, SER374F, THR278F, THR300G, THR333G, THR338G, THR341F, THR345F, THR345G, THR348F, THR348G, THR377F, THR378F, TYR301G, TYR304F, TYR304G, TYR310F, TYR320G, TYR343F, TYR347F, TYR347G, VAL250F, VAL251F, VAL307F, VAL309F, VAL322G, VAL351G
• F-K: ASN264F, SER267F, SER391K
• F-M: ALA259F, ARG276M, ARG289M, ARG357M, ASN264F, ASN272M, ASN280M, ASN313F, ASN342F, ASN344F, ASN372F, ASP265F, ASP273F, ASP273M, GLN256F, GLN256M, GLN261F, GLU292M, GLU294M, GLU308F, GLY255F, GLY257F, GLY257M, GLY291M, GLY339F, HIS287M, HIS376F, ILE260F, ILE277M, ILE371F, LEU253M, LEU266F, LEU286M, LEU296M, LYS263F, LYS282M, LYS285M, LYS340F, LYS359M, LYS375F, LYS375M, MET279M, MET373F, PHE284M, PRO281M, PRO288M, SER258F, SER275M, SER290M, SER370F, SER374F, THR278M, THR341F, THR345F, THR377F, THR378F, TRP274M, TYR310F, TYR311F, TYR343F, VAL262F, VAL309F
• G-M: ALA318G, ARG289M, ARG334G, ASN264M, ASN272M, ASP265M, ASP273M, ASP316G, CYS332G, GLN331G, PHE317G, SER319G, SER335G, THR315G, THR333G, VAL365G
• H-I: ALA249H, ALA318I, ALA349H, ALA349I, ALA382H, ALA388I, ARG334H, ARG334I, ARG384H, ARG384I, ASN280H, ASN342H, ASN344H, ASN344I, ASN372H, ASP316I, CYS332I, CYS346H, CYS346I, CYS352I, GLN247H, GLN247I, GLN254H, GLN306H, GLN331I, GLU308H, GLU321I, GLU337H, GLU337I, GLU387I, GLY350I, GLY381H, GLY386I, HIS252H, HIS376H, ILE277H, ILE303H, ILE303I, ILE336H, ILE336I, ILE383H, ILE383I, LEU253H, LEU330I, LEU353I, LEU385H, LEU385I, LYS282H, LYS327I, LYS340H, LYS375H, MET279H, PHE302H, PHE302I, PHE317I, PHE329I, PHE379H, PRO248H, PRO248I, PRO281H, PRO328I, PRO389I, SER305H, SER305I, SER319I, SER335H, SER335I, SER374H, THR278H, THR300I, THR315I, THR333I, THR338I, THR341H, THR345H, THR345I, THR348H, THR348I, THR377H, THR378H, TYR301I, TYR304H, TYR304I, TYR310H, TYR320I, TYR343H, TYR347H, TYR347I, VAL250H, VAL251H, VAL307H, VAL309H, VAL322I, VAL351I
• H-J: ALA249J, ALA318H, ALA349H, ALA349J, ALA382J, ALA388H, ARG334H, ARG334J, ARG384J, ASN342J, ASN344H, ASN344J, ASN372J, ASP316H, CYS332H, CYS346H, CYS346J, CYS352H, GLN254J, GLN306J, GLN331H, GLU308J, GLU321H, GLU337H, GLU337J, GLU387H, GLY350H, GLY381J, GLY386H, HIS252J, HIS376J, ILE277J, ILE303H, ILE303J, ILE336H, ILE336J, ILE383H, ILE383J, LEU253J, LEU330H, LEU353H, LEU385H, LEU385J, LYS327H, LYS340J, LYS375J, MET279J, PHE302H, PHE302J, PHE317H, PHE329H, PHE379J, PHE380J, PRO248H, PRO248J, PRO328H, SER305J, SER319H, SER335H, SER335J, SER374J, THR278J, THR300H, THR315H, THR333H, THR338H, THR341J, THR345H, THR345J, THR348H, THR348J, THR377J, THR378J, TYR301H, TYR304H, TYR304J, TYR310J, TYR320H, TYR343J, TYR347H, TYR347J, VAL250J, VAL251J, VAL307J, VAL309J, VAL322H, VAL351H
• H-L: ARG289L, GLU326L, HIS366L, HIS376H, LYS263L, LYS340H, LYS363L, LYS375H, SER258H, THR341H, TYR343H
• I-J: ALA249I, ALA318J, ALA349I, ALA349J, ALA382I, ALA388J, ALA390J, ARG334I, ARG334J, ARG384I, ARG384J, ASN280I, ASN342I, ASN344I, ASN344J, ASN372I, ASP316J, CYS332J, CYS346I, CYS346J, CYS352J, GLN247I, GLN254I, GLN306I, GLN331J, GLU308I, GLU321J, GLU337I, GLU337J, GLU387J, GLY299J, GLY350J, GLY381I, GLY386J, HIS252I, HIS376I, ILE277I, ILE303I, ILE303J, ILE312J, ILE336I, ILE336J, ILE383I, ILE383J, LEU253I, LEU330J, LEU353J, LEU385I, LEU385J, LYS282I, LYS327J, LYS340I, LYS340J, LYS375I, MET279I, PHE302I, PHE302J, PHE317J, PHE329J, PHE379I, PRO248I, PRO248J, PRO281I, PRO328J, PRO389J, SER305I, SER319J, SER335J, SER374I, THR278I, THR300J, THR333J, THR338J, THR341I, THR345I, THR345J, THR348I, THR348J, THR377I, THR378I, TYR301J, TYR304I, TYR304J, TYR310I, TYR320J, TYR343I, TYR347I, TYR347J, VAL250I, VAL251I, VAL307I, VAL309I, VAL322J, VAL351J
• I-K: ALA259K, ARG289I, ASN264I, ASN342K, ASN372K, ASP265I, ASP273K, ASP325I, GLN254K, GLN256K, GLU292I, GLU308K, GLU326I, GLY257K, GLY268I, GLY269I, HIS287I, HIS366I, HIS376K, LEU266I, LYS263I, LYS359I, LYS363I, LYS375K, MET373K, SER258K, SER267I, SER290I, SER374K, THR341K, THR377K, TYR310K, TYR343K, VAL262I, VAL270I
• I-L: ALA318L, ALA367I, ALA367L, ASN313I, ASN313L, ASP316I, ASP316L, ASP325I, ASP325L, ASP368I, ASP368L, GLN331I, GLN331L, GLN358I, GLU321I, GLU321L, GLU326I, GLU326L, GLY268I, HIS366I, HIS366L, ILE312L, ILE369L, LYS263I, LYS263L, LYS327I, LYS327L, LYS359I, LYS359L, LYS363I, LYS363L, PHE314I, PHE314L, PHE317I, PHE317L, PHE329L, PRO328I, PRO328L, SER267I, SER319I, SER319L, SER335L, THR315I, THR315L, THR338L, VAL323I, VAL323L, VAL324I, VAL324L, VAL365I, VAL365L
• K-L: ALA249K, ALA318L, ALA349K, ALA349L, ALA382K, ALA388L, ALA390L, ARG334K, ARG334L, ARG384K, ARG384L, ASN246L, ASN280K, ASN342K, ASN344K, ASN344L, ASN372K, ASP316L, CYS332L, CYS346K, CYS346L, CYS352L, GLN247K, GLN254K, GLN306K, GLN331L, GLU308K, GLU321L, GLU337K, GLU337L, GLU387L, GLY299L, GLY350L, GLY381K, GLY386L, HIS252K, HIS376K, ILE277K, ILE303K, ILE303L, ILE336K, ILE336L, ILE383K, ILE383L, LEU253K, LEU330L, LEU353L, LEU385K, LEU385L, LYS282K, LYS327L, LYS340K, LYS375K, MET279K, PHE302K, PHE302L, PHE317L, PHE329L, PHE379K, PRO248K, PRO248L, PRO281K, PRO328L, PRO389L, SER305K, SER319L, SER335K, SER335L, SER374K, THR278K, THR300L, THR333L, THR341K, THR345K, THR345L, THR348K, THR348L, THR377K, THR378K, TYR301L, TYR304K, TYR304L, TYR310K, TYR320L, TYR343K, TYR347K, TYR347L, VAL250K, VAL251K, VAL309K, VAL322L, VAL351L
• K-M: ALA249M, ALA318K, ALA349K, ALA349M, ALA382M, ALA388K, ALA390K, ARG334K, ARG334M, ARG384K, ARG384M, ASN280M, ASN342M, ASN344K, ASN344M, ASN372M, ASP316K, CYS332K, CYS346K, CYS346M, CYS352K, GLN247K, GLN247M, GLN254M, GLN306M, GLN331K, GLU308M, GLU321K, GLU337K, GLU337M, GLU387K, GLY299K, GLY350K, GLY381M, GLY386K, HIS252M, HIS376M, ILE277M, ILE303K, ILE303M, ILE336K, ILE336M, ILE383K, ILE383M, LEU253M, LEU330K, LEU353K, LEU385K, LEU385M, LYS282M, LYS327K, LYS340M, LYS375M, MET279M, PHE284M, PHE302K, PHE302M, PHE317K, PHE329K, PHE379M, PHE380M, PRO248K, PRO248M, PRO281M, PRO328K, PRO389K, SER305M, SER319K, SER335K, SER335M, SER374M, SER391K, THR278M, THR300K, THR315K, THR333K, THR338K, THR341M, THR345K, THR345M, THR348K, THR348M, THR377M, THR378M, TYR301K, TYR304K, TYR304M, TYR310M, TYR320K, TYR343M, TYR347K, TYR347M, VAL250M, VAL251M, VAL309M, VAL322K, VAL351K
• L-M: ALA249L, ALA318M, ALA349L, ALA349M, ALA382L, ALA388M, ALA390M, ARG334L, ARG334M, ARG384L, ARG384M, ASN246L, ASN280L, ASN342L, ASN344L, ASN344M, ASN372L, ASP316M, CYS332M, CYS346L, CYS346M, CYS352M, GLN247L, GLN247M, GLN254L, GLN306L, GLN331M, GLU308L, GLU321M, GLU337L, GLU337M, GLU387M, GLY299M, GLY350M, GLY381L, GLY386M, HIS252L, HIS376L, ILE277L, ILE303L, ILE303M, ILE336L, ILE336M, ILE383L, ILE383M, LEU253L, LEU330M, LEU353M, LEU354M, LEU385L, LEU385M, LYS282L, LYS327M, LYS340L, LYS375L, MET279L, PHE284L, PHE302L, PHE302M, PHE317M, PHE329M, PHE379L, PHE380L, PRO248L, PRO248M, PRO281L, PRO328M, PRO389M, SER305L, SER305M, SER319M, SER335L, SER335M, SER374L, THR278L, THR300M, THR333M, THR338M, THR341L, THR345L, THR345M, THR348L, THR348M, THR377L, THR378L, TYR301M, TYR304L, TYR304M, TYR310L, TYR320M, TYR343L, TYR347L, TYR347M, VAL250L, VAL251L, VAL307L, VAL309L, VAL322M, VAL351M