1R8H

comparison of the structure and dna binding properties of the e2 proteins from an oncogenic and a non-oncogenic human papillomavirus

• Total interactions analyzed: 15
• Total true interactions: 6
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 106
  • Norm. En. per Res.: -4.84
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-129.1822	-12.9893	-370.866	-513.0375	106	22	4	14699	2	7	27
A-D	-2.2997	-2.8094	1152.88	1147.7709	38	14	0	3026	0	9	8
B-E	0.0	-1.5628	1162.85	1161.2872	36	14	0	3241	0	9	8
C-D	-122.3134	2.9334	-334.305	-453.6849	100	23	3	13246	0	4	19
C-F	0.0	-2.7394	1396.39	1393.6506	35	13	0	2777	0	8	7
E-F	-126.5778	4.6552	-348.61	-470.5326	101	23	3	13289	0	3	19

Interface residues

• A-B: ALA283A, ALA283B, ALA320A, ALA320B, ALA324A, ALA324B, ALA329A, ALA329B, ARG300A, ARG300B, ARG307A, ARG307B, ARG341A, ARG341B, ASN304A, ASN304B, ASP311A, ASP311B, GLN288A, GLN288B, GLN290A, GLN290B, GLN340A, GLN340B, GLY359A, GLY359B, HIS308A, HIS308B, HIS318A, HIS318B, HIS326A, HIS326B, HIS336A, HIS336B, HIS356A, HIS356B, HIS364A, HIS364B, ILE286A, ILE286B, ILE313A, ILE313B, ILE330A, ILE330B, LEU309A, LEU309B, LEU312A, LEU312B, LEU358A, LEU358B, LEU365A, LEU365B, LEU366A, LEU366B, LYS323A, LYS323B, LYS357A, LYS357B, MET361A, MET361B, MET363A, MET363B, PHE289A, PHE289B, PHE310A, PHE310B, PHE360A, PHE360B, PRO285A, PRO285B, PRO322A, PRO322B, PRO325A, PRO325B, SER282A, SER282B, SER314A, SER314B, SER315A, SER315B, SER321A, SER321B, SER362A, SER362B, THR284A, THR284B, THR316A, THR316B, THR332A, THR332B, THR334A, THR334B, TRP317A, TRP317B, TRP319A, TRP319B, TYR301A, TYR301B, TYR335A, TYR335B, VAL287A, VAL287B, VAL331A, VAL331B, VAL333A, VAL333B
• A-D: ARG300A, ARG300D, ARG302A, ARG302D, ASN294A, ASN294D, ASP304A, ASP304D, CYS295A, CYS295D, CYS298A, CYS298D, GLU292A, GLU292D, GLY291A, HIS328A, ILE354A, ILE354D, LEU296A, LEU296D, LYS297A, LYS297D, LYS305A, LYS305D, PHE299A, PHE299D, PRO351A, PRO351D, PRO352A, PRO352D, SER293A, SER293D, THR316A, THR316D, THR353A, THR353D, TYR301A, TYR301D
• B-E: ARG300B, ARG300E, ARG302B, ARG302E, ASN294B, ASN294E, ASP304E, CYS295B, CYS295E, CYS298B, CYS298E, GLU292B, GLU292E, ILE354B, ILE354E, LEU296B, LEU296E, LYS297B, LYS297E, LYS305B, LYS305E, LYS349B, PHE299B, PHE299E, PRO351B, PRO351E, PRO352B, PRO352E, SER293B, SER293E, THR316B, THR316E, THR353B, THR353E, TYR301B, TYR301E
• C-D: ALA283C, ALA283D, ALA320C, ALA320D, ALA324D, ALA329C, ALA329D, ARG300C, ARG300D, ARG307C, ARG307D, ARG341C, ARG341D, ASN304C, ASN304D, ASP311C, ASP311D, GLN288C, GLN288D, GLN290C, GLN290D, GLN340C, GLY359C, GLY359D, HIS306C, HIS308C, HIS318C, HIS318D, HIS326D, HIS336C, HIS336D, HIS356C, HIS356D, HIS364C, HIS364D, ILE286C, ILE286D, ILE313C, ILE313D, ILE330C, ILE330D, LEU309C, LEU312C, LEU312D, LEU358C, LEU358D, LEU365C, LEU365D, LEU366C, LEU366D, LYS297C, LYS323D, LYS327C, LYS327D, LYS357C, LYS357D, MET361C, MET361D, MET363C, MET363D, PHE289C, PHE289D, PHE310C, PHE310D, PHE360C, PHE360D, PRO285C, PRO285D, PRO322C, PRO322D, PRO325D, SER282C, SER282D, SER314C, SER314D, SER315C, SER315D, SER321C, SER321D, SER362C, SER362D, THR284C, THR284D, THR316C, THR316D, THR332C, THR332D, THR334C, THR334D, TRP317C, TRP317D, TRP319C, TRP319D, TYR335C, VAL287C, VAL287D, VAL331C, VAL331D, VAL333C, VAL333D
• C-F: ARG300C, ARG300F, ARG302C, ARG302F, ASN294C, ASN294F, CYS295C, CYS295F, CYS298C, CYS298F, GLU292C, GLU292F, GLY291C, ILE354C, ILE354F, LEU296C, LEU296F, LYS297C, LYS297F, LYS349C, LYS349F, PHE299C, PHE299F, PRO351C, PRO351F, PRO352C, PRO352F, SER293C, SER293F, THR316C, THR316F, THR353C, THR353F, TYR301C, TYR301F
• E-F: ALA283E, ALA283F, ALA320E, ALA320F, ALA324E, ALA329E, ALA329F, ARG300E, ARG300F, ARG307E, ARG307F, ARG341E, ARG341F, ASN304E, ASN304F, ASP311E, ASP311F, GLN288E, GLN288F, GLN290E, GLN290F, GLN340F, GLY359E, GLY359F, HIS306F, HIS308F, HIS318E, HIS318F, HIS326E, HIS336E, HIS336F, HIS356E, HIS356F, HIS364E, HIS364F, ILE286E, ILE286F, ILE313E, ILE313F, ILE330E, ILE330F, LEU309F, LEU312E, LEU312F, LEU358E, LEU358F, LEU365E, LEU365F, LEU366E, LEU366F, LYS297F, LYS323E, LYS327E, LYS327F, LYS357E, LYS357F, MET361E, MET361F, MET363E, MET363F, PHE289E, PHE289F, PHE310E, PHE310F, PHE360E, PHE360F, PRO285E, PRO285F, PRO322E, PRO322F, PRO325E, SER282E, SER282F, SER314E, SER314F, SER315E, SER315F, SER321E, SER321F, SER362E, SER362F, THR284E, THR284F, THR316E, THR316F, THR332E, THR332F, THR334E, THR334F, TRP317E, TRP317F, TRP319E, TRP319F, TYR301F, TYR335F, VAL287E, VAL287F, VAL331E, VAL331F, VAL333E, VAL333F