1R4N

appbp1-uba3-nedd8, an e1-ubiquitin-like protein complex with atp

• Total interactions analyzed: 66
• Total true interactions: 20
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 314
  • Norm. En. per Res.: -3.9092
• Hub Node: C(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-121.0518	-99.5561	-965.253	-1185.8609	313	67	19	40707	14	79	74
A-I	-12.7946	-13.2493	-79.516	-105.5599	58	2	0	3354	1	26	29
A-E	-7.5932	2.8676	8.595	3.8695	34	17	0	1955	2	31	16
B-I	-42.9623	-34.2874	-339.288	-416.5377	112	18	9	13344	1	21	20
B-D	-27.0896	4.231	-124.359	-147.2177	95	6	3	5689	0	32	35
B-E	-20.8457	12.21	-71.0571	-79.6928	70	27	0	4943	0	19	13
B-F	0.0	-0.7273	-24.7006	-25.4279	22	2	0	1147	0	11	9
C-D	-119.311	-108.2283	-955.762	-1183.3014	313	63	19	40611	15	80	72
C-J	-12.9766	-13.6284	-82.4984	-109.1034	60	4	0	3486	1	27	31
C-G	-6.5489	-18.1662	-12.62	-37.3351	25	1	0	677	2	22	12
C-H	0.0	16.2457	-44.0564	-27.8107	54	3	0	2743	0	13	12
D-J	-35.3992	-33.852	-342.952	-412.2032	113	21	9	13380	1	21	20
D-H	0.0	2.7171	-14.2322	-11.5151	18	1	0	755	0	10	6
E-F	-109.8486	-104.6308	-967.043	-1181.5224	313	69	19	40891	15	80	73
E-K	-11.538	-12.3451	-82.5097	-106.3928	61	3	0	3442	1	25	29
F-K	-31.1378	-34.174	-345.287	-410.5988	111	22	9	13590	1	21	20
F-H	-23.5395	2.0186	-124.544	-146.0649	95	5	3	5578	0	32	34
G-H	-126.8644	-106.7492	-993.886	-1227.4996	314	76	19	41397	15	79	73
G-L	-12.5829	-13.1984	-81.365	-107.1463	62	3	0	3413	1	26	30
H-L	-44.3278	-34.5936	-342.86	-421.7814	113	23	8	13473	1	21	20

Interface residues

• A-B: ALA107B, ALA189B, ALA216B, ALA268B, ALA291B, ALA293B, ALA297B, ALA300B, ALA301B, ALA304B, ALA314B, ALA334A, ALA40A, ALA487A, ALA488A, ALA494A, ALA495A, ALA500A, ALA501A, ALA502A, ALA530A, ALA68B, ALA70A, ARG114B, ARG15A, ARG16B, ARG18A, ARG223B, ARG267B, ARG26B, ARG274B, ARG279B, ARG287B, ARG347A, ARG391A, ARG484A, ARG78A, ARG85A, ARG90B, ARG95B, ASN112B, ASN117B, ASN178A, ASN18B, ASN264A, ASN272B, ASN296B, ASN319B, ASN325B, ASN344A, ASN447A, ASN48A, ASN517A, ASN66B, ASN72A, ASN73A, ASN87B, ASN89B, ASN97A, ASP113B, ASP12B, ASP14A, ASP177A, ASP22A, ASP252B, ASP326B, ASP328B, ASP331A, ASP335A, ASP420A, ASP453A, ASP476A, ASP477A, ASP69A, ASP84B, CYS118B, CYS303B, CYS483A, CYS61B, GLN11A, GLN130A, GLN16A, GLN25A, GLN270B, GLN282B, GLN343A, GLN449A, GLN503A, GLN512A, GLN527A, GLN77A, GLN91B, GLN94A, GLU10A, GLU14B, GLU183B, GLU226B, GLU25B, GLU263A, GLU267A, GLU306B, GLU348A, GLU422A, GLU44A, GLU451A, GLU481A, GLU489A, GLU504A, GLU62B, GLU68A, GLU91A, GLU95A, GLY157A, GLY15B, GLY184B, GLY21A, GLY283B, GLY28B, GLY329B, GLY337A, GLY444A, GLY486A, GLY498A, GLY499A, GLY524A, GLY53A, GLY67A, GLY71A, GLY71B, HIS175A, HIS19B, HIS211A, HIS227B, HIS23A, HIS32B, HIS480A, HIS491A, ILE164A, ILE257B, ILE273B, ILE288B, ILE289B, ILE299B, ILE316B, ILE329A, ILE333A, ILE340A, ILE454A, ILE45A, ILE493A, ILE506A, ILE515A, ILE521A, ILE81A, ILE99B, LEU111B, LEU151A, LEU158A, LEU17A, LEU19A, LEU224B, LEU24B, LEU280B, LEU318B, LEU322B, LEU330B, LEU342A, LEU425A, LEU497A, LEU49A, LEU51A, LEU63B, LEU64B, LEU67B, LEU69B, LEU76A, LEU7A, LEU88B, LEU8A, LEU93A, LEU93B, LEU96A, LYS103B, LYS12A, LYS186B, LYS21B, LYS22B, LYS286B, LYS309B, LYS338A, LYS341A, LYS351A, LYS475A, LYS47A, LYS507A, LYS65B, LYS97B, LYS9A, MET162A, MET221B, MET332A, MET428A, MET525A, PHE110B, PHE185B, PHE213B, PHE23B, PHE308B, PHE30B, PHE324B, PHE335B, PHE35B, PHE482A, PHE496A, PHE513A, PHE516A, PHE72B, PHE74A, PHE75A, PHE92A, PHE92B, PHE94B, PRO116B, PRO176A, PRO213A, PRO214B, PRO222B, PRO225B, PRO254B, PRO290B, PRO29B, PRO317B, PRO330A, PRO37B, PRO419A, PRO443A, PRO490A, PRO52A, PRO96B, SER174A, SER210A, SER220B, SER27B, SER294B, SER313B, SER336A, SER446A, SER523A, SER526A, SER529A, SER66A, SER70B, SER79A, SER86B, SER98A, THR155A, THR182B, THR217B, THR277B, THR281B, THR295B, THR305B, THR312B, THR31B, THR332B, THR334B, THR39A, THR39B, THR43A, THR492A, THR510A, THR519A, THR528A, THR531A, TRP13B, TRP17B, TRP20A, TYR13A, TYR156A, TYR271B, TYR278B, TYR315B, TYR321B, TYR331B, TYR333B, TYR339A, TYR442A, TYR448A, TYR478A, TYR485A, TYR520A, TYR522A, VAL115B, VAL159A, VAL191B, VAL20B, VAL284B, VAL285B, VAL292B, VAL298B, VAL302B, VAL307B, VAL323B, VAL327B, VAL393A, VAL424A, VAL445A, VAL450A, VAL479A, VAL50A, VAL514A, VAL65A, VAL85B
• A-I: ALA179A, ALA275A, ALA530A, ARG125I, ARG129I, ARG244A, ARG391A, ASN178A, ASN271A, ASN273A, ASN277A, ASP116I, ASP121I, ASP177A, GLN139I, GLN140I, GLN141I, GLU118I, GLU124I, GLU128I, GLU131I, GLU132I, GLU134I, GLU181A, GLU241A, GLU267A, GLY135I, HIS175A, ILE115I, ILE117I, ILE136I, ILE269A, LEU108I, LEU169I, LEU171I, LEU180A, LEU276A, LYS106I, LYS111I, LYS127I, LYS133I, LYS240A, LYS270A, PRO137I, PRO138I, PRO176A, PRO282A, SER283A, SER284A, THR107I, THR109I, THR120I, THR236A, THR274A, THR278A, TYR237A, VAL130I, VAL272A
• A-E: ARG138E, ARG347A, ASN111E, ASN115E, ASN344A, ASP114E, ASP116E, ASP335A, GLN343A, GLU106E, GLU107E, GLU110E, GLU191A, GLU348A, GLU377A, GLY337A, GLY62E, HIS195A, ILE340A, LEU112E, LEU113E, LYS338A, LYS341A, LYS349A, LYS351A, LYS352A, LYS381A, LYS437E, PHE189A, SER108E, SER336A, TYR346A, VAL105E, VAL345A
• B-I: ALA172I, ALA189B, ALA198B, ALA291B, ALA337B, ALA372B, ALA56B, ARG142I, ARG151B, ARG174I, ARG190B, ARG287B, ARG339B, ARG90B, ASN151I, ASN188B, ASN296B, ASN320B, ASN325B, ASP146B, ASP152I, ASP179B, ASP326B, ASP328B, CYS143B, CYS202B, CYS61B, GLN139I, GLN140I, GLN141I, GLN149I, GLN210B, GLN375B, GLN91B, GLU112I, GLU183B, GLU201B, GLU205B, GLU336B, GLU338B, GLU341B, GLY110I, GLY144B, GLY147I, GLY175I, GLY176I, GLY180B, GLY181B, GLY184B, GLY187B, GLY329B, GLY55B, GLY57B, GLY58B, GLY60B, HIS168I, ILE144I, ILE148B, ILE149B, ILE200B, ILE288B, ILE289B, ILE299B, LEU108I, LEU143I, LEU145B, LEU167I, LEU169I, LEU171I, LEU173I, LEU204B, LEU206B, LEU322B, LEU330B, LEU59B, LYS103B, LYS106I, LYS111I, LYS127I, LYS148I, LYS186B, LYS340B, MET150I, PHE185B, PHE324B, PHE335B, PRO137I, PRO138I, PRO208B, PRO209B, PRO290B, SER146I, SER147B, SER373B, THR107I, THR109I, THR182B, THR203B, THR295B, THR332B, THR334B, TYR145I, TYR159I, TYR207B, TYR321B, TYR331B, TYR333B, VAL166I, VAL170I, VAL211B, VAL323B, VAL327B
• B-D: ALA108B, ALA108D, ALA383B, ALA383D, ARG101B, ARG101D, ASN112B, ASN112D, ASN119B, ASN119D, ASN125B, ASN125D, ASN131B, ASN131D, ASN163B, ASN163D, ASN389B, ASN389D, ASP129B, ASP129D, ASP132B, ASP132D, ASP166B, ASP166D, ASP170B, ASP170D, GLN128B, GLN128D, GLN137B, GLN137D, GLN908B, GLN908D, GLU105B, GLU105D, GLU109B, GLU109D, GLU165B, GLU165D, GLU604B, GLU604D, GLU605B, GLU605D, HIS123B, HIS123D, HIS76B, HIS76D, ILE127B, ILE127D, ILE78B, ILE78D, LEU911B, LEU911D, LYS126B, LYS126D, LYS50B, LYS50D, MET157B, MET157D, MET80B, PHE124B, PHE124D, PHE130B, PHE130D, PHE134B, PHE134D, PHE138B, PHE138D, PRO102B, PRO102D, PRO122B, PRO122D, SER602B, SER602D, THR133B, THR133D, THR382B, THR382D, THR384B, THR384D, THR601B, THR601D, TRP153B, TRP153D, TYR135B, TYR135D, TYR164B, TYR164D, VAL120B, VAL120D, VAL121B, VAL121D, VAL600B, VAL600D, VAL901B, VAL901D
• B-E: ALA219B, ALA268B, ALA70E, ALA86E, ARG267B, ARG274B, ARG441E, ARG78E, ARG85E, ASN111E, ASN272B, ASN447E, ASN63E, ASN84E, ASP61E, ASP69E, GLN236B, GLN241B, GLN258B, GLN262B, GLN270B, GLN439E, GLN449E, GLN64E, GLU106E, GLU107E, GLU110E, GLU240B, GLU255B, GLU266B, GLU452E, GLU68E, GLY275B, GLY440E, GLY62E, GLY67E, GLY71E, GLY82E, HIS436E, ILE273B, ILE60E, ILE81E, LEU112E, LEU235B, LEU265B, LYS239B, LYS263B, LYS83E, PHE261B, PRO109E, PRO132E, PRO225B, SER108E, SER220B, SER269B, SER446E, SER66E, SER80E, THR277B, TRP237B, TRP259B, TYR231B, TYR271B, TYR278B, TYR442E, TYR448E, VAL105E, VAL276B, VAL445E, VAL65E
• B-F: ARG16F, ASN18F, GLN258B, GLN262B, GLU14F, GLU240B, GLU255B, GLU266B, GLY15F, HIS19F, HIS256B, ILE257B, ILE260B, LYS21F, LYS22F, LYS263B, PHE243B, PHE261B, PRO242B, PRO254B, TRP13F, TRP259B
• C-D: ALA107D, ALA189D, ALA216D, ALA268D, ALA291D, ALA293D, ALA297D, ALA300D, ALA301D, ALA304D, ALA314D, ALA334C, ALA40C, ALA487C, ALA488C, ALA494C, ALA495C, ALA500C, ALA501C, ALA502C, ALA530C, ALA68D, ALA70C, ARG114D, ARG15C, ARG16D, ARG18C, ARG223D, ARG267D, ARG26D, ARG274D, ARG279D, ARG287D, ARG347C, ARG391C, ARG484C, ARG78C, ARG85C, ARG90D, ARG95D, ASN112D, ASN117D, ASN178C, ASN18D, ASN264C, ASN272D, ASN296D, ASN319D, ASN325D, ASN344C, ASN447C, ASN48C, ASN517C, ASN66D, ASN72C, ASN73C, ASN87D, ASN89D, ASN97C, ASP113D, ASP12D, ASP146D, ASP14C, ASP177C, ASP22C, ASP252D, ASP326D, ASP328D, ASP331C, ASP335C, ASP420C, ASP453C, ASP476C, ASP477C, ASP69C, ASP84D, CYS118D, CYS303D, CYS483C, CYS61D, GLN11C, GLN130C, GLN16C, GLN25C, GLN270D, GLN282D, GLN343C, GLN449C, GLN503C, GLN512C, GLN527C, GLN77C, GLN91D, GLN94C, GLU10C, GLU14D, GLU183D, GLU226D, GLU25D, GLU263C, GLU267C, GLU306D, GLU348C, GLU422C, GLU44C, GLU451C, GLU481C, GLU489C, GLU504C, GLU62D, GLU68C, GLU91C, GLU95C, GLY157C, GLY15D, GLY184D, GLY21C, GLY275D, GLY283D, GLY28D, GLY329D, GLY337C, GLY444C, GLY486C, GLY498C, GLY499C, GLY524C, GLY53C, GLY67C, GLY71C, GLY71D, HIS175C, HIS19D, HIS211C, HIS227D, HIS23C, HIS32D, HIS480C, HIS491C, ILE257D, ILE273D, ILE288D, ILE289D, ILE299D, ILE316D, ILE329C, ILE333C, ILE340C, ILE454C, ILE45C, ILE493C, ILE506C, ILE515C, ILE521C, ILE81C, ILE99D, LEU111D, LEU151C, LEU158C, LEU17C, LEU19C, LEU224D, LEU24D, LEU280D, LEU28C, LEU318D, LEU322D, LEU330D, LEU342C, LEU425C, LEU497C, LEU49C, LEU51C, LEU63D, LEU64D, LEU67D, LEU69D, LEU76C, LEU7C, LEU88D, LEU8C, LEU93C, LEU93D, LEU96C, LYS103D, LYS12C, LYS186D, LYS21D, LYS22D, LYS286D, LYS309D, LYS338C, LYS341C, LYS351C, LYS475C, LYS47C, LYS507C, LYS65D, LYS97D, LYS9C, MET162C, MET221D, MET332C, MET525C, PHE110D, PHE185D, PHE213D, PHE23D, PHE308D, PHE30D, PHE324D, PHE335D, PHE35D, PHE482C, PHE496C, PHE513C, PHE516C, PHE72D, PHE74C, PHE75C, PHE92C, PHE92D, PHE94D, PRO116D, PRO176C, PRO213C, PRO214D, PRO222D, PRO225D, PRO254D, PRO290D, PRO29D, PRO317D, PRO330C, PRO37D, PRO419C, PRO443C, PRO490C, PRO52C, PRO96D, SER174C, SER210C, SER220D, SER27D, SER294D, SER313D, SER336C, SER446C, SER523C, SER526C, SER529C, SER66C, SER70D, SER79C, SER86D, SER98C, THR155C, THR182D, THR217D, THR277D, THR281D, THR295D, THR305D, THR312D, THR31D, THR332D, THR334D, THR39C, THR39D, THR43C, THR492C, THR510C, THR519C, THR528C, THR531C, TRP13D, TRP17D, TRP20C, TYR13C, TYR156C, TYR271D, TYR278D, TYR315D, TYR321D, TYR331D, TYR333D, TYR339C, TYR448C, TYR478C, TYR485C, TYR520C, TYR522C, VAL115D, VAL159C, VAL191D, VAL20D, VAL284D, VAL285D, VAL292D, VAL298D, VAL302D, VAL307D, VAL323D, VAL327D, VAL393C, VAL424C, VAL445C, VAL450C, VAL479C, VAL50C, VAL514C, VAL65C, VAL85D
• C-J: ALA179C, ALA275C, ALA530C, ARG125J, ARG129J, ARG244C, ARG391C, ASN178C, ASN271C, ASN273C, ASN277C, ASP116J, ASP121J, ASP177C, GLN139J, GLN140J, GLN141J, GLU118J, GLU124J, GLU128J, GLU131J, GLU132J, GLU134J, GLU181C, GLU241C, GLU267C, GLY135J, HIS175C, ILE115J, ILE117J, ILE136J, ILE269C, LEU108J, LEU169J, LEU171J, LEU180C, LEU276C, LYS106J, LYS111J, LYS127J, LYS133J, LYS240C, LYS270C, MET101J, PRO137J, PRO138J, PRO176C, PRO282C, PRO330C, SER283C, SER284C, THR107J, THR109J, THR120J, THR236C, THR274C, THR278C, TYR237C, VAL130J, VAL272C
• C-G: ARG138C, ARG347G, ARG78C, ASN111C, ASN115C, ASN344G, ASP114C, ASP116C, GLU106C, GLU107C, GLU110C, GLU191G, GLU348G, GLU377G, GLY62C, LEU112C, LEU7G, LYS341G, LYS349G, LYS351G, LYS352G, LYS381G, SER108C, VAL105C, VAL345G
• C-H: ALA268H, ARG267H, ARG274H, ARG441C, ARG78C, ARG85C, ASN111C, ASN272H, ASN447C, ASN63C, ASP61C, ASP69C, GLN236H, GLN241H, GLN258H, GLN262H, GLN270H, GLN439C, GLN449C, GLN64C, GLU106C, GLU107C, GLU110C, GLU240H, GLU266H, GLU452C, GLU68C, GLY275H, GLY440C, GLY62C, GLY67C, GLY82C, HIS436C, ILE273H, ILE81C, LEU265H, LYS239H, LYS263H, PHE261H, PRO109C, SER108C, SER269H, SER446C, SER66C, THR277H, TRP237H, TRP259H, TYR231H, TYR271H, TYR442C, TYR448C, VAL276H, VAL445C, VAL65C
• D-J: ALA172J, ALA189D, ALA198D, ALA291D, ALA337D, ALA372D, ALA56D, ARG142J, ARG151D, ARG174J, ARG190D, ARG287D, ARG339D, ARG90D, ASN151J, ASN188D, ASN296D, ASN320D, ASN325D, ASP146D, ASP152J, ASP179D, ASP326D, ASP328D, CYS143D, CYS202D, CYS61D, GLN139J, GLN140J, GLN141J, GLN149J, GLN210D, GLN375D, GLN91D, GLU112J, GLU183D, GLU201D, GLU205D, GLU336D, GLU338D, GLU341D, GLY110J, GLY144D, GLY147J, GLY175J, GLY176J, GLY180D, GLY181D, GLY184D, GLY187D, GLY329D, GLY55D, GLY57D, GLY58D, GLY60D, HIS168J, ILE144J, ILE148D, ILE149D, ILE200D, ILE288D, ILE289D, ILE299D, LEU108J, LEU143J, LEU145D, LEU167J, LEU169J, LEU171J, LEU173J, LEU204D, LEU206D, LEU322D, LEU330D, LEU59D, LYS103D, LYS106J, LYS111J, LYS127J, LYS148J, LYS186D, LYS340D, MET150J, PHE185D, PHE324D, PHE335D, PRO137J, PRO138J, PRO208D, PRO209D, PRO290D, SER146J, SER147D, SER373D, THR107J, THR109J, THR182D, THR203D, THR295D, THR332D, THR334D, TYR145J, TYR159J, TYR207D, TYR321D, TYR331D, TYR333D, VAL105J, VAL166J, VAL170J, VAL211D, VAL323D, VAL327D
• D-H: ARG16D, ASN18D, GLN258H, GLN262H, GLU14D, GLU255H, GLU266H, GLY15D, HIS256H, ILE257H, ILE260H, LYS22D, LYS263H, PHE243H, PHE261H, PRO254H, TRP13D, TRP259H
• E-F: ALA107F, ALA189F, ALA216F, ALA268F, ALA291F, ALA293F, ALA297F, ALA300F, ALA301F, ALA304F, ALA314F, ALA334E, ALA40E, ALA487E, ALA488E, ALA494E, ALA495E, ALA500E, ALA501E, ALA502E, ALA530E, ALA68F, ALA70E, ARG114F, ARG15E, ARG16F, ARG18E, ARG223F, ARG267F, ARG26F, ARG274F, ARG279F, ARG287F, ARG347E, ARG391E, ARG484E, ARG78E, ARG85E, ARG90F, ARG95F, ASN112F, ASN117F, ASN178E, ASN18F, ASN264E, ASN272F, ASN296F, ASN319F, ASN325F, ASN344E, ASN447E, ASN48E, ASN517E, ASN66F, ASN72E, ASN73E, ASN87F, ASN89F, ASN97E, ASP113F, ASP12F, ASP146F, ASP14E, ASP177E, ASP22E, ASP252F, ASP326F, ASP328F, ASP331E, ASP335E, ASP420E, ASP453E, ASP476E, ASP477E, ASP69E, ASP84F, CYS118F, CYS153E, CYS303F, CYS483E, CYS61F, GLN11E, GLN130E, GLN16E, GLN25E, GLN270F, GLN282F, GLN343E, GLN449E, GLN503E, GLN512E, GLN527E, GLN77E, GLN91F, GLN94E, GLU10E, GLU14F, GLU183F, GLU226F, GLU25F, GLU263E, GLU267E, GLU306F, GLU348E, GLU44E, GLU451E, GLU481E, GLU489E, GLU504E, GLU62F, GLU68E, GLU91E, GLU95E, GLY157E, GLY15F, GLY184F, GLY21E, GLY275F, GLY283F, GLY28F, GLY329F, GLY337E, GLY444E, GLY486E, GLY498E, GLY499E, GLY524E, GLY53E, GLY67E, GLY71E, GLY71F, HIS175E, HIS19F, HIS211E, HIS227F, HIS23E, HIS32F, HIS480E, HIS491E, ILE257F, ILE273F, ILE288F, ILE289F, ILE299F, ILE316F, ILE329E, ILE333E, ILE340E, ILE454E, ILE45E, ILE493E, ILE506E, ILE515E, ILE521E, ILE81E, ILE99F, LEU111F, LEU151E, LEU158E, LEU17E, LEU19E, LEU224F, LEU24F, LEU280F, LEU28E, LEU318F, LEU322F, LEU330F, LEU342E, LEU425E, LEU497E, LEU49E, LEU51E, LEU63F, LEU64F, LEU67F, LEU69F, LEU76E, LEU7E, LEU88F, LEU8E, LEU93E, LEU93F, LEU96E, LYS103F, LYS12E, LYS186F, LYS21F, LYS22F, LYS286F, LYS309F, LYS338E, LYS341E, LYS351E, LYS475E, LYS47E, LYS507E, LYS65F, LYS97F, LYS9E, MET162E, MET221F, MET332E, MET525E, PHE110F, PHE185F, PHE213F, PHE23F, PHE308F, PHE30F, PHE324F, PHE335F, PHE35F, PHE482E, PHE496E, PHE513E, PHE516E, PHE72F, PHE74E, PHE75E, PHE92E, PHE92F, PHE94F, PRO116F, PRO176E, PRO213E, PRO214F, PRO222F, PRO225F, PRO254F, PRO290F, PRO29F, PRO317F, PRO330E, PRO37F, PRO419E, PRO443E, PRO490E, PRO52E, PRO96F, SER174E, SER210E, SER220F, SER27F, SER294F, SER313F, SER336E, SER446E, SER523E, SER526E, SER529E, SER66E, SER70F, SER79E, SER86F, SER98E, THR155E, THR182F, THR217F, THR277F, THR281F, THR295F, THR305F, THR312F, THR31F, THR332F, THR334F, THR39E, THR39F, THR43E, THR492E, THR510E, THR519E, THR528E, THR531E, TRP13F, TRP17F, TRP20E, TYR13E, TYR156E, TYR271F, TYR278F, TYR315F, TYR321F, TYR331F, TYR333F, TYR339E, TYR448E, TYR478E, TYR485E, TYR520E, TYR522E, VAL115F, VAL159E, VAL191F, VAL20F, VAL284F, VAL285F, VAL292F, VAL298F, VAL302F, VAL307F, VAL323F, VAL327F, VAL393E, VAL424E, VAL445E, VAL450E, VAL479E, VAL50E, VAL514E, VAL65E, VAL85F
• E-K: ALA179E, ALA275E, ALA530E, ARG125K, ARG129K, ARG244E, ARG391E, ASN178E, ASN271E, ASN273E, ASN277E, ASP116K, ASP121K, ASP177E, GLN139K, GLN140K, GLN141K, GLU118K, GLU124K, GLU128K, GLU131K, GLU132K, GLU134K, GLU181E, GLU241E, GLU267E, GLY135K, HIS175E, ILE115K, ILE117K, ILE136K, ILE269E, LEU108K, LEU169K, LEU171K, LEU180E, LEU276E, LYS106K, LYS111K, LYS127K, LYS133K, LYS240E, LYS270E, PRO137K, PRO138K, PRO176E, PRO282E, PRO330E, SER283E, SER284E, THR107K, THR109K, THR120K, THR236E, THR274E, THR278E, THR531E, TYR237E, VAL130K, VAL272E, VAL514E
• F-K: ALA172K, ALA189F, ALA198F, ALA291F, ALA337F, ALA372F, ALA56F, ARG142K, ARG151F, ARG174K, ARG190F, ARG287F, ARG339F, ARG90F, ASN151K, ASN188F, ASN296F, ASN320F, ASN325F, ASP146F, ASP152K, ASP179F, ASP326F, ASP328F, CYS143F, CYS202F, CYS61F, GLN139K, GLN140K, GLN141K, GLN149K, GLN210F, GLN375F, GLN91F, GLU112K, GLU183F, GLU201F, GLU205F, GLU336F, GLU338F, GLU341F, GLY110K, GLY144F, GLY147K, GLY175K, GLY176K, GLY180F, GLY181F, GLY184F, GLY187F, GLY329F, GLY55F, GLY57F, GLY58F, GLY60F, HIS168K, ILE144K, ILE148F, ILE149F, ILE200F, ILE288F, ILE289F, ILE299F, LEU108K, LEU143K, LEU145F, LEU167K, LEU169K, LEU171K, LEU173K, LEU204F, LEU206F, LEU322F, LEU330F, LEU59F, LYS103F, LYS106K, LYS111K, LYS148K, LYS186F, LYS340F, MET150K, PHE185F, PHE324F, PHE335F, PRO137K, PRO138K, PRO208F, PRO209F, PRO290F, SER146K, SER147F, SER373F, THR107K, THR109K, THR182F, THR203F, THR295F, THR332F, THR334F, TYR145K, TYR159K, TYR207F, TYR321F, TYR331F, TYR333F, VAL166K, VAL170K, VAL211F, VAL323F, VAL327F
• F-H: ALA108F, ALA108H, ALA383F, ALA383H, ARG101F, ARG101H, ARG136F, ASN112F, ASN112H, ASN119F, ASN119H, ASN125F, ASN125H, ASN131F, ASN131H, ASN163F, ASN163H, ASN389F, ASN389H, ASP129F, ASP129H, ASP132F, ASP132H, ASP166F, ASP166H, ASP170F, ASP170H, GLN128F, GLN128H, GLN137F, GLN137H, GLN908F, GLN908H, GLU105F, GLU105H, GLU109F, GLU109H, GLU165F, GLU165H, GLU605F, GLU605H, GLY100F, HIS123F, HIS123H, HIS76F, HIS76H, ILE127F, ILE127H, ILE78F, ILE78H, LEU911F, LEU911H, LYS126F, LYS126H, LYS50F, LYS50H, MET157F, MET157H, PHE124F, PHE124H, PHE130F, PHE130H, PHE134F, PHE134H, PHE138F, PHE138H, PRO102F, PRO102H, PRO122F, PRO122H, SER396H, SER602F, SER602H, THR133F, THR133H, THR382F, THR382H, THR384F, THR384H, THR601F, THR601H, TRP153F, TRP153H, TYR135F, TYR135H, TYR164F, TYR164H, VAL120F, VAL120H, VAL121F, VAL121H, VAL600F, VAL600H, VAL901F, VAL901H
• G-H: ALA107H, ALA189H, ALA216H, ALA268H, ALA291H, ALA293H, ALA297H, ALA300H, ALA301H, ALA304H, ALA314H, ALA334G, ALA40G, ALA487G, ALA488G, ALA494G, ALA495G, ALA500G, ALA501G, ALA502G, ALA530G, ALA68H, ALA70G, ARG114H, ARG15G, ARG16H, ARG18G, ARG223H, ARG267H, ARG26H, ARG274H, ARG279H, ARG287H, ARG347G, ARG391G, ARG484G, ARG78G, ARG85G, ARG90H, ARG95H, ASN112H, ASN117H, ASN178G, ASN18H, ASN264G, ASN272H, ASN296H, ASN319H, ASN325H, ASN344G, ASN447G, ASN48G, ASN517G, ASN66H, ASN72G, ASN73G, ASN87H, ASN89H, ASN97G, ASP113H, ASP12H, ASP14G, ASP177G, ASP22G, ASP252H, ASP326H, ASP328H, ASP331G, ASP335G, ASP420G, ASP453G, ASP476G, ASP477G, ASP69G, ASP84H, CYS118H, CYS303H, CYS483G, CYS61H, GLN11G, GLN130G, GLN16G, GLN25G, GLN270H, GLN282H, GLN343G, GLN449G, GLN503G, GLN512G, GLN527G, GLN77G, GLN91H, GLN94G, GLU10G, GLU14H, GLU183H, GLU226H, GLU25H, GLU263G, GLU267G, GLU306H, GLU348G, GLU422G, GLU44G, GLU451G, GLU481G, GLU489G, GLU504G, GLU62H, GLU68G, GLU91G, GLU95G, GLY157G, GLY15H, GLY184H, GLY21G, GLY275H, GLY283H, GLY28H, GLY329H, GLY337G, GLY444G, GLY486G, GLY498G, GLY499G, GLY524G, GLY53G, GLY67G, GLY71G, GLY71H, HIS175G, HIS19H, HIS211G, HIS227H, HIS23G, HIS32H, HIS480G, HIS491G, ILE164G, ILE257H, ILE273H, ILE288H, ILE289H, ILE299H, ILE316H, ILE329G, ILE333G, ILE340G, ILE454G, ILE45G, ILE493G, ILE506G, ILE515G, ILE521G, ILE81G, ILE99H, LEU111H, LEU151G, LEU158G, LEU17G, LEU19G, LEU224H, LEU24H, LEU280H, LEU28G, LEU318H, LEU322H, LEU330H, LEU342G, LEU425G, LEU497G, LEU49G, LEU51G, LEU63H, LEU64H, LEU67H, LEU69H, LEU76G, LEU7G, LEU88H, LEU8G, LEU93G, LEU93H, LEU96G, LYS103H, LYS12G, LYS186H, LYS21H, LYS22H, LYS286H, LYS309H, LYS338G, LYS341G, LYS351G, LYS475G, LYS47G, LYS507G, LYS65H, LYS97H, LYS9G, MET162G, MET221H, MET332G, MET428G, MET525G, PHE110H, PHE185H, PHE213H, PHE23H, PHE308H, PHE30H, PHE324H, PHE335H, PHE35H, PHE482G, PHE496G, PHE513G, PHE516G, PHE72H, PHE74G, PHE75G, PHE92G, PHE92H, PHE94H, PRO116H, PRO176G, PRO213G, PRO214H, PRO222H, PRO225H, PRO254H, PRO290H, PRO29H, PRO317H, PRO330G, PRO37H, PRO419G, PRO443G, PRO490G, PRO52G, PRO96H, SER174G, SER210G, SER220H, SER27H, SER294H, SER313H, SER336G, SER446G, SER523G, SER526G, SER529G, SER66G, SER70H, SER79G, SER86H, SER98G, THR155G, THR182H, THR217H, THR277H, THR281H, THR295H, THR305H, THR312H, THR31H, THR332H, THR334H, THR39G, THR39H, THR43G, THR492G, THR510G, THR519G, THR528G, THR531G, TRP13H, TRP17H, TRP20G, TYR13G, TYR156G, TYR271H, TYR278H, TYR315H, TYR321H, TYR331H, TYR333H, TYR339G, TYR448G, TYR478G, TYR485G, TYR520G, TYR522G, VAL115H, VAL159G, VAL191H, VAL20H, VAL284H, VAL285H, VAL292H, VAL298H, VAL302H, VAL307H, VAL323H, VAL327H, VAL393G, VAL424G, VAL445G, VAL450G, VAL479G, VAL50G, VAL514G, VAL65G, VAL85H
• G-L: ALA179G, ALA275G, ALA530G, ARG125L, ARG129L, ARG244G, ARG391G, ASN178G, ASN271G, ASN273G, ASN277G, ASP116L, ASP121L, ASP177G, GLN139L, GLN140L, GLN141L, GLU118L, GLU124L, GLU128L, GLU131L, GLU132L, GLU134L, GLU181G, GLU241G, GLU267G, GLY110L, GLY135L, HIS175G, ILE115L, ILE117L, ILE136L, ILE269G, LEU108L, LEU169L, LEU171L, LEU180G, LEU276G, LYS106L, LYS111L, LYS127L, LYS133L, LYS240G, LYS270G, PRO137L, PRO138L, PRO176G, PRO282G, PRO330G, SER283G, SER284G, THR107L, THR109L, THR120L, THR236G, THR274G, THR278G, THR531G, TYR237G, VAL130L, VAL272G, VAL514G
• H-L: ALA172L, ALA189H, ALA198H, ALA291H, ALA337H, ALA372H, ALA56H, ARG142L, ARG151H, ARG174L, ARG190H, ARG287H, ARG339H, ARG90H, ASN151L, ASN188H, ASN296H, ASN320H, ASN325H, ASP146H, ASP152L, ASP179H, ASP326H, ASP328H, CYS143H, CYS202H, CYS61H, GLN139L, GLN140L, GLN141L, GLN149L, GLN210H, GLN375H, GLN91H, GLU112L, GLU183H, GLU201H, GLU205H, GLU336H, GLU338H, GLU341H, GLY110L, GLY144H, GLY147L, GLY175L, GLY176L, GLY180H, GLY181H, GLY184H, GLY187H, GLY329H, GLY55H, GLY57H, GLY58H, GLY60H, HIS168L, ILE144L, ILE148H, ILE149H, ILE200H, ILE288H, ILE289H, ILE299H, LEU108L, LEU143L, LEU145H, LEU167L, LEU169L, LEU171L, LEU173L, LEU204H, LEU206H, LEU322H, LEU330H, LEU59H, LYS103H, LYS106L, LYS111L, LYS127L, LYS148L, LYS186H, LYS340H, MET150L, PHE185H, PHE324H, PHE335H, PRO137L, PRO138L, PRO208H, PRO209H, PRO290H, SER146L, SER147H, SER373H, THR107L, THR109L, THR182H, THR203H, THR295H, THR332H, THR334H, TYR145L, TYR159L, TYR207H, TYR321H, TYR331H, TYR333H, VAL105L, VAL166L, VAL170L, VAL211H, VAL323H, VAL327H