1QX7

crystal structure of apocam bound to the gating domain of small conductance ca2+-activated potassium channel

• Total interactions analyzed: 15
• Total true interactions: 10
• Strongest Interaction:
  • Chains: I-R
  • Int. Res.: 153
  • Norm. En. per Res.: -6.3769
• Hub Node: I(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
I-R	-121.9504	-207.2124	-646.508	-975.6708	153	64	36	28488	9	86	83
I-A	0.0	126.2374	-80.2882	45.9492	64	3	1	3271	0	38	79
I-M	0.0	49.9803	-16.3656	33.6147	17	4	0	681	0	3	12
I-D	-9.9872	0.0	-11.7107	-21.6979	14	5	0	581	0	2	5
R-M	0.0	118.4682	-71.9753	46.4929	50	6	1	2829	2	28	56
R-D	0.0	0.0	-0.4938	-0.4938	5	0	0	86	0	2	3
A-B	-126.3483	-93.186	-678.406	-897.9403	156	66	38	28577	6	91	83
A-M	-9.0682	57.1538	-24.9798	23.1059	14	5	0	719	0	2	13
A-D	0.0	0.0	-0.4012	-0.4012	2	0	0	49	0	0	2
M-D	-13.003	0.0	-78.717	-91.72	32	30	0	3613	1	8	7

Interface residues

• I-R: ALA102I, ALA102R, ALA103I, ALA103R, ALA128I, ALA128R, ALA15I, ALA15R, ALA88I, ALA88R, ARG106I, ARG106R, ARG126I, ARG126R, ARG37I, ARG37R, ARG86I, ARG86R, ARG90I, ARG90R, ASN111I, ASN111R, ASN137I, ASN137R, ASN97I, ASN97R, ASP118I, ASP118R, ASP122I, ASP122R, ASP129I, ASP129R, ASP131I, ASP131R, ASP133I, ASP133R, ASP80I, ASP80R, ASP93I, ASP93R, ASP95I, ASP95R, GLN135I, GLN135R, GLN143I, GLN143R, GLN41I, GLN41R, GLU104I, GLU104R, GLU114I, GLU114R, GLU119I, GLU119R, GLU11I, GLU11R, GLU123I, GLU123R, GLU139I, GLU139R, GLU140I, GLU140R, GLU14I, GLU14R, GLU82I, GLU82R, GLU83I, GLU83R, GLU84I, GLU84R, GLU87I, GLU87R, GLY113I, GLY113R, GLY134I, GLY134R, GLY33I, GLY33R, GLY40I, GLY40R, GLY96I, GLY96R, GLY98I, GLY98R, HIS107I, HIS107R, ILE100I, ILE100R, ILE125I, ILE125R, ILE130I, ILE130R, ILE85I, ILE85R, LEU105I, LEU105R, LEU112I, LEU112R, LEU116I, LEU116R, LEU18I, LEU18R, LEU39I, LEU39R, LYS115I, LYS115R, LYS13I, LYS13R, LYS94I, LYS94R, PHE12I, PHE12R, PHE141I, PHE141R, PHE16I, PHE16R, PHE19I, PHE19R, PHE89I, PHE89R, PHE92I, PHE92R, SER101I, SER101R, SER17R, SER38I, SER38R, SER81I, SER81R, THR110I, THR110R, THR117I, THR117R, THR146I, THR146R, THR34I, THR34R, TYR138I, TYR138R, TYR99I, TYR99R, VAL108I, VAL108R, VAL121I, VAL121R, VAL136I, VAL136R, VAL142I, VAL142R, VAL35I, VAL35R, VAL91I, VAL91R
• I-A: ALA10A, ALA10I, ALA128A, ALA128I, ARG126A, ARG126I, ASP122A, ASP122I, ASP129A, ASP129I, ASP20A, ASP20I, ASP22A, ASP22I, ASP24A, ASP24I, ASP64A, ASP64I, GLN8A, GLN8I, GLU119A, GLU119I, GLU120A, GLU120I, GLU123A, GLU123I, GLU127A, GLU127I, GLU14A, GLU14I, GLU67A, GLU67I, GLU6A, GLU6I, GLU7A, GLU7I, GLY23A, GLY23I, GLY25A, GLY25I, ILE125A, ILE125I, ILE130A, ILE9A, LEU18A, LEU18I, LEU69A, LEU69I, LYS13A, LYS13I, LYS21A, LYS21I, PHE16A, PHE16I, PHE65A, PHE65I, PRO66A, PRO66I, SER17A, SER17I, THR26A, THR26I, THR5A, THR5I
• I-M: ALA10I, ASP118M, ASP122M, GLN3I, GLN8I, GLU119M, GLU11I, GLU120M, GLU123M, GLU6I, GLU7I, ILE9I, LEU116M, LEU4I, LYS115M, THR117M, THR5I
• I-D: ASN437D, ASP2I, GLN3I, GLN8I, GLU11I, GLU430D, GLU6I, GLU7I, ILE9I, LEU433D, LYS436D, SER81I, THR431D, THR5I
• R-M: ALA10M, ALA10R, ALA128R, ARG126R, ASP122R, ASP129R, ASP20M, ASP20R, ASP22M, ASP22R, ASP24M, ASP24R, ASP64M, GLN8R, GLU119R, GLU11M, GLU120R, GLU123R, GLU127R, GLU14M, GLU14R, GLU67M, GLU6M, GLU6R, GLU7M, GLU7R, GLY23M, GLY23R, GLY25M, GLY25R, ILE125R, ILE130R, ILE9M, ILE9R, LEU18M, LEU18R, LEU69M, LYS13M, LYS13R, LYS21M, LYS21R, PHE16M, PHE65M, PRO66M, SER17M, SER17R, THR26M, THR5M, THR5R, THR62M
• R-D: ASN437D, GLU114R, ILE434D, LYS115R, THR438D
• A-B: ALA102A, ALA102B, ALA103A, ALA103B, ALA128A, ALA128B, ALA15A, ALA15B, ALA1B, ALA88A, ALA88B, ARG106A, ARG106B, ARG126A, ARG37A, ARG37B, ARG86A, ARG86B, ARG90A, ARG90B, ASN111A, ASN111B, ASN137A, ASN137B, ASN97A, ASN97B, ASP118A, ASP118B, ASP122A, ASP122B, ASP129A, ASP129B, ASP131A, ASP131B, ASP133A, ASP133B, ASP2A, ASP80A, ASP80B, ASP93A, ASP93B, ASP95A, ASP95B, GLN135A, GLN135B, GLN143A, GLN143B, GLN41A, GLN41B, GLN8A, GLU104A, GLU104B, GLU114A, GLU114B, GLU119A, GLU119B, GLU11A, GLU11B, GLU120A, GLU120B, GLU123A, GLU139A, GLU139B, GLU140A, GLU140B, GLU14A, GLU14B, GLU82A, GLU82B, GLU83A, GLU83B, GLU84A, GLU84B, GLU87A, GLU87B, GLY113A, GLY113B, GLY134A, GLY134B, GLY33A, GLY33B, GLY40A, GLY40B, GLY96A, GLY96B, GLY98A, GLY98B, HIS107A, HIS107B, ILE100A, ILE100B, ILE125A, ILE125B, ILE130A, ILE130B, ILE85A, ILE85B, LEU105A, LEU105B, LEU112A, LEU112B, LEU116A, LEU116B, LEU18A, LEU18B, LEU39A, LEU39B, LYS115A, LYS115B, LYS94A, LYS94B, PHE12A, PHE12B, PHE141A, PHE141B, PHE16A, PHE16B, PHE19A, PHE19B, PHE89A, PHE89B, PHE92A, PHE92B, SER101A, SER101B, SER17A, SER38A, SER38B, SER81A, SER81B, THR110A, THR110B, THR117A, THR117B, THR146A, THR146B, THR34A, THR34B, THR79A, THR79B, TYR138A, TYR138B, TYR99A, TYR99B, VAL108A, VAL108B, VAL121A, VAL121B, VAL136A, VAL136B, VAL142A, VAL142B, VAL35A, VAL35B, VAL91A, VAL91B
• A-M: ASP118M, ASP122M, GLN3A, GLN8A, GLU119M, GLU120M, GLU6A, GLU7A, ILE9A, LEU116M, LEU4A, THR117M, THR5A, VAL121M
• A-D: GLU430D, GLU6A
• M-D: ALA147M, ALA57M, ALA88M, ASN437D, ASP118M, GLN143M, GLU119M, GLU120M, GLU123M, GLU127M, GLU430D, GLU82M, GLU83M, GLU84M, ILE434D, ILE85M, LEU116M, LEU433D, LEU440D, LYS115M, LYS436D, LYS439D, PHE141M, PHE89M, SER81M, THR117M, THR146M, THR431D, THR438D, TRP432D, TYR435D, VAL121M