1QTY

vascular endothelial growth factor in complex with domain 2 of the flt-1 receptor

• Total interactions analyzed: 28
• Total true interactions: 12
• Strongest Interaction:
  • Chains: S-T
  • Int. Res.: 56
  • Norm. En. per Res.: -2.7646
• Hub Node: S(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
V-W	-107.1536	-39.4714	985.769	839.1439	121	40	10	16019	2	16	20
V-X	0.0	7.4897	-40.6469	-33.1572	33	3	1	2587	0	4	11
V-Y	-4.9006	-32.2481	-114.067	-151.2157	55	5	5	5290	1	19	12
W-X	0.0	-25.6064	-116.118	-141.7244	57	6	5	5516	1	18	13
W-Y	0.0	7.6635	-40.0966	-32.4331	33	3	1	2849	0	5	12
R-S	-113.5529	-40.6332	1010.16	855.9739	121	30	10	16281	2	16	22
R-T	0.0	7.1596	-57.1174	-49.9578	33	4	2	3088	0	5	12
R-U	-2.7602	-22.1161	-127.001	-151.8773	59	11	5	5819	1	18	15
S-X	0.0	0.0	-10.7791	-10.7791	16	0	0	614	0	12	11
S-T	-8.7087	-30.6674	-115.442	-154.8181	56	8	5	5513	1	20	13
S-U	0.0	5.7403	-39.1617	-33.4214	30	3	1	2355	0	4	11
X-T	0.0	2.6622	-33.4996	-30.8374	32	8	0	2240	1	12	13

Interface residues

• V-W: ARG23V, ARG23W, ARG56V, ARG56W, ARG82V, ARG82W, ASN62V, ASN62W, ASN75W, ASP19V, ASP19W, ASP34V, ASP34W, ASP63V, ASP63W, CYS26V, CYS26W, CYS51V, CYS51W, CYS57V, CYS57W, CYS60V, CYS60W, CYS61V, CYS61W, CYS68V, CYS68W, GLN22V, GLN22W, GLN79V, GLN79W, GLN98V, GLN98W, GLU13V, GLU13W, GLU30V, GLU30W, GLU64V, GLU64W, GLU93V, GLU93W, GLY58V, GLY58W, GLY59V, GLY59W, GLY92V, GLY92W, HIS27V, HIS27W, HIS90V, ILE29V, ILE29W, ILE35V, ILE35W, ILE46V, ILE46W, ILE76V, ILE76W, ILE80V, ILE80W, ILE83V, ILE83W, ILE91V, ILE91W, LEU32V, LEU32W, LEU54V, LEU54W, LEU66W, LYS16V, LYS16W, LYS48V, LYS48W, MET18V, MET18W, MET55V, MET55W, MET78V, MET78W, MET81V, MET81W, MET94V, MET94W, PHE17V, PHE17W, PHE36V, PHE36W, PHE47V, PHE47W, PHE96V, PHE96W, PRO28V, PRO28W, PRO49V, PRO49W, PRO53V, PRO53W, SER24V, SER24W, SER50V, SER50W, SER95V, SER95W, THR31V, THR31W, THR77V, THR77W, TYR21V, TYR21W, TYR25V, TYR25W, VAL14V, VAL14W, VAL15V, VAL15W, VAL20V, VAL20W, VAL33V, VAL33W, VAL52V, VAL52W
• V-X: ARG224X, ARG82V, GLN225X, GLN79V, GLN87V, GLN89V, GLU141X, GLU144X, GLY203X, GLY88V, GLY92V, HIS147X, HIS223X, HIS86V, HIS90V, ILE142X, ILE145X, ILE146X, ILE202X, ILE46V, ILE80V, ILE83V, ILE91V, LEU204X, LEU221X, LYS48V, LYS84V, MET81V, PHE47V, PRO143X, PRO49V, PRO85V, THR222X
• V-Y: ARG105V, ARG224Y, ARG23V, ASN219Y, ASN62V, ASP175Y, ASP19V, ASP63V, CYS102V, CYS104V, CYS26V, CYS61V, GLN225Y, GLN22V, GLU103V, GLU141Y, GLU150Y, GLU201Y, GLU64V, GLU67V, GLY203Y, GLY65V, HIS223Y, HIS27V, ILE142Y, ILE145Y, ILE202Y, LEU174Y, LEU204Y, LEU205Y, LEU221Y, LEU66V, LYS101V, LYS107V, LYS16V, LYS171Y, LYS200Y, LYS217Y, MET148Y, MET18V, PHE172Y, PHE17V, PRO106V, PRO143Y, PRO173Y, PRO28V, SER140Y, SER24V, THR198Y, THR206Y, THR222Y, TYR199Y, TYR21V, TYR220Y, TYR25V
• W-X: ARG105W, ARG224X, ARG23W, ASN219X, ASN62W, ASP175X, ASP19W, ASP63W, CYS102W, CYS104W, CYS26W, CYS61W, GLN225X, GLN22W, GLU103W, GLU141X, GLU150X, GLU201X, GLU64W, GLU67W, GLY203X, GLY65W, HIS223X, HIS27W, ILE142X, ILE145X, ILE202X, LEU174X, LEU204X, LEU205X, LEU221X, LEU66W, LYS101W, LYS107W, LYS16W, LYS171X, LYS200X, LYS217X, MET148X, MET18W, PHE172X, PHE17W, PRO106W, PRO143X, PRO173X, PRO28W, SER140X, SER24W, THR198X, THR206X, THR222X, THR71W, TYR139X, TYR199X, TYR21W, TYR220X, TYR25W
• W-Y: ARG224Y, ARG82W, GLN225Y, GLN79W, GLN87W, GLN89W, GLU141Y, GLU144Y, GLY203Y, GLY88W, GLY92W, HIS147Y, HIS223Y, HIS86W, HIS90W, ILE142Y, ILE145Y, ILE146Y, ILE202Y, ILE46W, ILE80W, ILE83W, ILE91W, LEU204Y, LEU221Y, LYS48W, LYS84W, MET81W, PHE47W, PRO143Y, PRO49W, PRO85W, THR222Y
• R-S: ARG23R, ARG23S, ARG56R, ARG56S, ARG82R, ARG82S, ASN62R, ASN62S, ASN75R, ASP19R, ASP19S, ASP34R, ASP34S, ASP63R, ASP63S, CYS26R, CYS26S, CYS51R, CYS51S, CYS57R, CYS57S, CYS60R, CYS60S, CYS61R, CYS61S, CYS68R, CYS68S, GLN22R, GLN22S, GLN79R, GLN79S, GLN98R, GLN98S, GLU13R, GLU13S, GLU30R, GLU30S, GLU64R, GLU64S, GLU93R, GLU93S, GLY58R, GLY58S, GLY59R, GLY59S, GLY92R, GLY92S, HIS27R, HIS27S, HIS90R, HIS90S, ILE29R, ILE29S, ILE35R, ILE35S, ILE46R, ILE46S, ILE76R, ILE76S, ILE80R, ILE80S, ILE83R, ILE83S, ILE91R, ILE91S, LEU32R, LEU32S, LEU54R, LEU54S, LEU66R, LYS16R, LYS16S, LYS48R, LYS48S, MET18R, MET18S, MET55R, MET55S, MET78R, MET78S, MET81R, MET81S, MET94R, MET94S, PHE17R, PHE17S, PHE36S, PHE47R, PHE47S, PHE96R, PHE96S, PRO28R, PRO28S, PRO49R, PRO49S, PRO53R, PRO53S, SER24R, SER24S, SER50R, SER50S, SER95R, SER95S, THR31R, THR31S, THR77R, THR77S, TYR21R, TYR21S, TYR25R, TYR25S, VAL14R, VAL14S, VAL15R, VAL15S, VAL20R, VAL20S, VAL33R, VAL33S, VAL52R, VAL52S
• R-T: ARG224T, ARG82R, GLN225T, GLN79R, GLN87R, GLN89R, GLU141T, GLU144T, GLY203T, GLY88R, GLY92R, HIS147T, HIS223T, HIS86R, HIS90R, ILE142T, ILE145T, ILE146T, ILE202T, ILE46R, ILE80R, ILE83R, ILE91R, LEU204T, LEU221T, LYS48R, LYS84R, MET81R, PHE47R, PRO143T, PRO49R, PRO85R, THR222T
• R-U: ARG105R, ARG224U, ARG23R, ASN100R, ASN219U, ASN62R, ASP175U, ASP19R, ASP63R, CYS102R, CYS104R, CYS26R, CYS61R, GLN225U, GLN22R, GLU103R, GLU141U, GLU150U, GLU201U, GLU64R, GLU67R, GLY203U, GLY65R, HIS223U, HIS27R, ILE142U, ILE145U, ILE202U, LEU174U, LEU204U, LEU205U, LEU221U, LEU66R, LYS101R, LYS107R, LYS16R, LYS171U, LYS200U, LYS217U, MET148U, MET18R, PHE172U, PHE17R, PRO106R, PRO143U, PRO173U, PRO28R, SER140U, SER24R, THR198U, THR206U, THR218U, THR222U, THR71R, TYR139U, TYR199U, TYR21R, TYR220U, TYR25R
• S-X: ARG105S, ARG183X, ASP180X, ASP187X, ASP63S, GLY181X, GLY65S, ILE184X, ILE185X, LEU66S, LYS107S, LYS108S, LYS182X, PRO106S, PRO179X, TRP186X
• S-T: ARG105S, ARG224T, ARG23S, ASN219T, ASN62S, ASP175T, ASP19S, ASP63S, CYS102S, CYS104S, CYS26S, CYS61S, GLN225T, GLN22S, GLU103S, GLU141T, GLU150T, GLU201T, GLU64S, GLU67S, GLY203T, GLY65S, HIS223T, HIS27S, ILE142T, ILE145T, ILE202T, LEU174T, LEU204T, LEU205T, LEU221T, LEU66S, LYS101S, LYS107S, LYS16S, LYS171T, LYS200T, LYS217T, MET148T, MET18S, PHE172T, PHE17S, PRO106S, PRO143T, PRO173T, PRO28S, SER140T, SER24S, THR198T, THR206T, THR222T, TYR139T, TYR199T, TYR21S, TYR220T, TYR25S
• S-U: ARG224U, GLN225U, GLN79S, GLN87S, GLN89S, GLU141U, GLU144U, GLY203U, GLY88S, HIS147U, HIS223U, HIS86S, HIS90S, ILE142U, ILE145U, ILE146U, ILE202U, ILE46S, ILE83S, ILE91S, LEU204U, LEU221U, LYS48S, LYS84S, MET81S, PHE47S, PRO143U, PRO49S, PRO85S, THR222U
• X-T: ALA197T, ARG183T, ARG183X, ARG224T, ASN196T, ASP180T, ASP180X, GLU150T, GLU201T, GLU208X, GLY151T, GLY181X, ILE178X, ILE184T, ILE184X, ILE185X, ILE194T, ILE202T, LEU177X, LEU215X, LYS170X, LYS182T, LYS182X, LYS200T, PRO179X, SER195T, THR166X, THR168X, THR176X, THR198T, TRP186X, TYR199T